Dissertations / Theses on the topic 'Homeopathic treatment of allergic rhinitis'

Background: Persistent allergic rhinitis (PAR) is a common disorder affecting substantial number of people worldwide. In Australia, allergic rhinitis affects 16% of the population. Increasingly, patients are seeking alternative therapies especially acupuncture for allergic diseases. Objective: This study aimed to evaluate the effectiveness and safety of acupuncture in the treatment of persistent allergic rhinitis. Methods: Eighty (80) subjects aged between 16 and 70 were randomly assigned to either real or sham acupuncture groups. Each patient received either real or sham acupuncture treatments twice per week for the period of eight weeks. Daily symptom scores by subjects using five-point scale was employed as the primary outcome measure to assess the severity of nasal symptoms every day. The secondary outcome measures were rhinoconjunctivitis quality of life questionnaire (RQLQ) and relief medication scores. Relief medication scores were recorded every day by subjects whereas RQLQ assessment was monitored fortnightly throughout the trial and at the end of three-month follow-up period. Results: Compared to the control group, the real acupuncture group demonstrated more improvement of nasal symptoms after eight-week treatment and significant after the follow-up periods. Significant differences between the two groups were also shown in terms of RQLQ. While there were not significantly Relief medication scores were more reduced in real acupuncture group than those in control group, although the differences were not significant. Both real and sham acupuncture treatments were well tolerated. Conclusion: The findings of this study suggest that acupuncture is potentially an effective and safe option of treatment for persistent allergic rhinitis and it may improve patients' quality of life.

A dissertation submitted in partial compliance with the requirements for the Master's Diploma in Technology: Homoeopathy at Technikon Natal, 1994.
The purpose of this study was to evaluate the efficacy of simillimum and allergen treatment to patients allergic to mixed grass pollens in terms of patients' responses to RAST and patients' percept ion of the effectiveness of treatment in order to identify key issues calling for the selection of the most effective method of treatment.
M

Submitted in partial compliance with requirements for Master`s Degree in Technology: Homoeopathy, Durban University of Technology, Durban, South Africa, 2017.
Allergic rhinitis (AR) is a symptomatic disorder of the nose characterized by inflammation of the nasal mucosa. It consists of a group of disorders that are all typified by the presence of one or more of the following: nasal itching, congestion, sneezing and rhinorrhoea (Wallace et. al., 2008). Allergic rhinitis can result in decreased quality of life, decreased sleep quantity, obstructive sleep apnoea and impaired performance at work and school (Blaiss, 2010: 375-380). According to Small and Kim (2011) allergic rhinitis (AR) is the most common allergic condition and one of the most common of all minor afflictions. It affects between 10- 20% of all people in the United States, and the prevalence of the disorder is increasing. This may result in significant impairment to quality of life, sleep and work performance (Small and Kim 2011). A therapeutic goal for patients suffering from allergic rhinitis is to prevent or minimise symptoms, using treatment with minimal effects or no side effects and of reasonable expenses, so that patients may maintain a normal life style (DiPiroet al.2002). Homoeopathy is a complete system of medicine developed by German physician and chemist, Dr Samuel Hahnemann (1755-1843). It is based on the following theories, first the doctrine of signature that disease is curable by those drugs which produce effect on the body similar to the symptoms of the disease “similia similibus currantur”; second that the effects of the drug are increased by giving it in a minute dose, which is obtained by dilution or trituration to an extreme limit and thirdly the notion that chronic disease are only manifestation of suppressed itch or psora (Ernst 2016). Similasan Nasal Allergy Relief Spray® is commercially available as a homoeopathic nasal spray. It is based on the principle of "let likes cure likes" or the Law of Similars. According to the company, this product is 100% natural, and contains active ingredients with non-drowsy effects which relieves allergic congestion, itching and runny nose, and it is preservative free (Similasan Corporation 1999-2015). Similasan Nasal Allergy ReliefSpray® mist gently stimulates the body's natural ability to relieve allergic congestion, itchy, runny nose and rhinitis caused by pollen, pet dander, dust and mould spores. Furthermore, the Similasan Nasal Allergy ReliefSpray® mists is non-habit forming and will not cause reliance or a rebound effect. The ingredients are: Cardiospermum 6X, Galphimiaglauca 6X, Luffa operculata 6X, Sabadilla 6X (SimilasanCoorporation 1999-2015). The aim of this double-blind randomised controlled study is to determine the efficacy of the homoeopathic Similasan Nasal Allergy Relief Spray® in the management of allergic rhinitis. Outcomes were monitored using questionnaires and a daily log book. This was a quantitative study which included thirty participants suffering from allergic rhinitis. Participants volunteered to participate in the study, were over the age of eighteen and consented to the procedure of the study. Participants involved in the research study were randomly divided into treatment group and placebo group. The treatment group received Similasan Nasal Allergy Relief Spray® and the placebo group received a saline nasal spray. The research study was conducted over a period of four weeks at the Durban University of Technology Homoeopathic Day Clinic. Participants were instructed to rate their symptoms before, during and after taking treatment (Appendix, C and D). The parametric test used in this study was Independent Samples T- Test. Non-parametric tests included ANOVA and Pearson chi-square. Rhinorrhoea, sneezing, itching of the eyes and nasal congestion showed a statistically significant results but some of the participant’s symptoms deteriorated after a period of improvement. This research determined that Similisan Nasal Allergy Relief Spray ® didn’t have a significant effect in treating allergic rhinitis in terms of the CARAT questionnaire.
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M.Tech. (Homoeopathy)
Allergic Rhinitis (AR) is the inflammation of the nasal and often conjunctival mucous membrane. It manifests due to the exposure of inhaled allergic agents and results in an immunoglobulin E (lgE) mediated reaction (DiPiro et al., 2002; Shargel et al., 2001). Allergic rhinitis is characterised by four principle symptoms, watery rhinorrhoea, nasal obstruction, nasal itching and sneezing (Min, 2010). In addition to the cardinal symptoms experienced during AR other common symptoms include postnasal drip, pruritic eyes; ears; nose and palate (Kemp, 2009). Although allergic rhinitis is not life threatening, the adverse impact on quality of life is significant. Those affected by allergic rhinitis are restricted in their ability to carry out their normal daily activities (Nelson, 2007; Wilson et al., 2002). Sleep, social interaction, emotional well being as well as cognitive and psychomotor function are affected by allergic rhinitis, and can lead to impaired learning ability. Serious disorders such as eczema, asthma, sinusitis, otitis media, nasal polyposis, respiratory infections and orthodontic malocclusions are. frequently linked with allergic rhinitis (DiPiro et al., 2002; Kemp, 2009)., The therapeutic goal for patients suffering with allergic rhinitis is to prevent or minimise symptoms, using treatment with minimal or no side effects and of reasonable expense, so that patients may maintain a normal lifestyle (DiPiro et aI., 2002). One of the most frequent indications for which homoeopathic treatment is sought after is for respiratory allergies (Ramchandani, 2009). Thus it has been proposed that the remedies contained within Otirin Nasal Spray"; namely Allium cepa, Euphrasia officinalis, Luffa operculata and Sabadilla officinarummay be effective as a treatment for allergic rhinitis (Vermeulen, 2000). Otirin Nasal Spray" is a homoeopathic complex preparation indicated for allergic rhinitis. No specific research has been conducted on this product to determine its efficacy in this condition (Medford, 2008). The aim of this research study was to determine the efficacy of Otirin Nasal Spray" in the treatment of allergic rhinitis with regard to the severity Of symptoms; specifically on the symptoms relating to the nose, eyes, throat, mouth and ears. Diary cards and questionnaires were completed, making use of the severity of symptoms scores to grade the symptoms. This research study was a quantitative" double-blind, placebo-controlled study and included thirty participants suffering from AR. Participants volunteered to participate in the study, were over the age of eighteen and consented to the procedures of the research study. Participants involved in the study were randomly divided into a treatment (experimental) group and a control (placebo) group. The treatment group received the Otirin Nasal Spray'" as opposed to the control group who received the placebo nasal spray (saline nasal spray). The research study was conducted over a period of four weeks at the UJ Health Centre. Participants were instructed to complete an individual "Treatment Diary Card" (Appendix E) during each hayfever attack by scoring the severity of each symptom they suffered from. During the final consultation the "Response to Treatment Questionnaire" (Appendix F) was completed under the researcher's supervision. This questionnaire required participants to score an amelioration, aggravation, no change or not applicable for each symptom, as well as other associated symptoms. Results acquired from the research study were statistically analysed by Statkon at the University of Johannesburg by means of descriptive statistics, parametric and non-parametric tests. The parametric test included the Independent Samples TTest. Non-parametric tests included the Friedman Test, Wilcoxon Signed Rank, and Mann-Whitney U Test. This research study determined that the homoeopathically prepared Otirin Nasal Spray" did have a statistically significant effect in the treatment of allergic rhinitis symptoms. A trend towards a decrease in the severity of the participant's symptoms was observed, in particular for rhinorrhoea, sneezing, nasal blockage/congestion, pruritic/itchy eyes and postnasal drip.

M.Tech.
Allergic rhinitis, otherwise referred to as hay fever, is a common allergic reaction affecting the nose, throat, eyes, and respiratory system, of persons of all ages and both sexes. This study attempted to demonstrate the effect of the homoeopathically prepared remedy Sabadilla officinarum 30CH and Sabadilla officinarum 200CH in the treatment of allergic rhinitis. Thirty participants were selected for this one hour, double-blind, placebo-controlled study. The participants were randomly placed into one of three groups of ten, consisting of the control group, and the two experimental groups. The control group received the placebo medication. The first experimental group received Sabadilla officinarum 30CH, and the second experimental group received Sabadilla officinarum 200CH. The patients were all supplied with: a stat dose of medication to use at the time of an allergic rhinitis attack, a diary card on which to score the severity of their symptoms at the time of such an attack, and a response to treatment questionnaire to fill in after the completion of their treatment. The results were statistically analysed using the Wilcoxon Signed Ranks Test, the Kruskal Wallis Test, and descriptive statistics. The results show that treatment with Sabadilla officinarum 30CH and 200CH had a significant effect in improving the symptoms of allergic rhinitis.

M.Tech.
Allergic rhinitis is on the increase around the world affecting between 15-20% of the global population and is the most common chronic condition of children in South Africa. Luffeel® is a propriety complex homeopathic product manufactured by Biologische Heilmittel Heel. It is available in nasal spray and tablet form. These two forms are designed to work in combination with each other in the treatment of allergic rhinitis. The aim of this study is to determine the effect of a combination of Luffeel® nasal spray and Luffeel® tablets on allergic rhinitis using Phadiatop® tests, RAST Inhalant screens and subjective evaluation on symptoms such as nasal itching, sneezing, congestion, discharge, ocular redness and itching as indicators. This study was a double-blind, placebo-controlled study conducted at the University of Johannesburg, Doornfontein campus over a period of eight weeks. Thirty participants were recruited by poster advertisement. It can be concluded that Luffeel® nasal spray and Luffeel® tablets decrease the symptoms of allergic rhinitis, when compared to the placebo, thus giving persons suffering from allergic rhinitis an alternative treatment with no rebound or lethargic effects. It can also be concluded that this study that Luffeel® nasal spray and Luffeel® tablets has no significant effect on Phadiatop® and RAST inhalant screens over an eight week period. The results are inconclusive due to the small sample size and short time frame of the study.

碩士
中山醫學大學
醫學研究所
95
Background：Allergic rhinitis is one of the most common chronic condition. The purpose of this study is to measure the outcome of treatment of allergic rhinitis with diode laser in contact mode, with a long-term follow-up of 6 years. Methods：From September 1999 to May 2000, forty-two newly diagnosed patients participated in the study .These 42 consecutive patients were treated with a continuous diode laser (wavelength：805nm, laser parameter：12W) in “contact” mode and under local anesthesia. All patients were refractory to conservative medical treatment. After a follow-up of 6 years, we measured the result of treatment by an allergy outcome survey questionnaire in the 3 months, 6 months, 1 year and 6 years following the operation. Results：Twenty-five of 42 patients (60%) who replied filled out the questionnaire completely. The mean operation time took 1 minute and 28 seconds per patient, no nasal packing was necessary and no complication (e.g., major bleeding) was observed. Statistical analysis revealed：except the medication score in post-operation 1 year, significant improvement in the symptom score, medication score and total score 3 months,6 months,1 year and 6 years after laser surgery were found. A total of 64% of the patients described the improvement of medication score and 72% of the patients described the improvement of total score 6 years after laser treatment. The outcome of laser surgery still persists for 6 years after dioide laser surgery. Conclusion：Long-term follow-up of 6 years results revealed that diode laser treatment of allergic rhinitis is an useful procedure, which can be performed as an outpatient surgery under local anesthesia. The short operation time and less discomfort provide other reasons for choosing this treatment for allergic rhinitis.

Trabalho Final do Curso de Mestrado Integrado em Medicina, Faculdade de Medicina, Universidade de Lisboa, 2015
The management of patients with perennial nonallergic or idiopathic rhinitis is difficult. Diagnosis and treatment are hampered by several factors. First, the diagnosis is made by exclusion of other nasal diseases, essentially allergy tests such as RAST, skin prick tests. As a consequence, idiopathic rhinitis is not defined according to clear criteria. A commonly accepted phenotype of idiopathic rhinitis is not yet fully elucidated. In contrast with allergic rhinitis, inflammation does not appear to play a major role in idiopathic rhinitis. Recent studies indicate a neural dysregulation of the nasal mucosa. Additionally, the available therapeutic arsenal comprising both pharmacotherapy and surgery is at best partially efficacious in these patients. The efficacy of repeated capsaicin application has been established in several randomized controlled trials. This treatment modality nay be the first step to more specific and better treatment options for patients with idiopathic rhinitis that is unresponsive to standard treatment with steroids.
A abordagem clinica de um paciente com rinite idiopática perene não alérgica é um desafio que nem sempre é possível vencer. O diagnóstico e o tratamento são dificultados por diversos factores. Primeiramente este é feito por exclusão de outras patologias nasais, essencialmente doença alérgica efectuando para isso testes RAST e prick. Como consequência, a rinite idiopática não tem critérios de diagnóstico bem estabelecidos, assim como não existe um fenótipo desta patologia bem estabelecido. Contrastante com a rinite alérgica, a inflamação não parece desempenhar um papel principal. Estudos recentes indicam que poderá existir uma desregulação neuronal localizada ao nível da mucosa nasal. Adicionalmente o arsenal terapêutico composto por farmacoterapia e cirurgia nasal é apenas parcialmente eficaz no alivio da sintomatologia. A eficácia de aplicações repetidas de capsaicina foi estabelecida em diversos ensaios clínicos aleatorizados e controlados, sendo que se efectuou uma pesquisa e analise detalhada dos mesmos, sendo a eficácia da capsaicina algo já documentado. Esta modalidade terapêutica poderá ser o primeiro passo para um tratamento mais específico e dirigido para a rinite idiopática que não é responsiva ao tratamento com corticosteróides.

碩士
南華大學
自然醫學研究所
95
The purpose of this clinical study was to investigate the effect of Tian-Jiou hyposensitization treatment using acupoint herbal patch on allergic rhinitis subjects sensitive to Blomia tropicalis (Bt) and to evaluate the practicality of using such treatment as a form of complementary medicine. In 2004 and 2005, 197 and 70 subjects with allergic rhinitis symptoms were recruited into the study, respectively. They were divided into Bt-positive group (Bt＋) and Bt-negative group (Bt－). The effect of the treatment was evaluated using specific IgE test (Bt. allergen), total symptom score, and Ryodoraku energy analysis. Results showed that the mean value of specific IgE test was significantly reduced (p<0.05) in the subjects of the Bt+ group. With respect to the total symptom score, both groups improved after the treatment. We concluded that the appropriate use of Tian-Jiou treatment can be used as an effective complementary medicine in patients with allergic rhinitis.

碩士
嘉南藥理大學
藥學系
105
Abstract Allergic Rhinitis (AR) is an inflammatory reaction in nasal membrane where Immunoglobulin E (IgE) serves as a medium. AR is a common upper respiratory condition causing discomfort and affecting our health. AR, a risk factor of asthma, often coexists with asthma. Therefore, it is important to use medication in AR treatment. This retrospective study aims to analyze the medical treatment in allergic rhinitis retrieving data from one of the ENT clinical in New Taipei City during the year of 99 to 103 [(ICD_9 CM) 477.9]. Statistical analysis in this study included descriptive covariance and inferential statistics for age, sex, months, and medications were analyzed using SPSS/12.0. The study found that the development of AR often happened in October to January and thus increased numbers of hospital visits. Seven to eighteen year old male patients developed AR more often than other age group. The study found that there are two types of medication to treat AR. One of the type is oral antihistamine medication (57.9%) and the brand Levocetirizine dihydrochloride is the most common medication while compared to other medication (52.9%). The other type of medication is steroid nasal spray (42.1%) and the brand Mometasone furoate was more often to be prescribed to patients comparing to other brand sprays (25.5%). Oral antihistamine medication was used more often than steroid nasal spray in both male and female. The study also found no significant difference in numbers of clinic visits or medication use in either male or female patients. However, there is a significant difference in age group between 7 to 18 years with 17.8 % rate of Levocetirizine dihydrochloride use.

碩士
中國醫藥大學
中西醫結合研究所碩士班
98
Purpose: There are six hundred million people suffered from allergic rhinitis by estimation. Among them, two hundred million people are suffered from asthma. Both experts and patients are searching for more noninvasive, more convenient, more effective and cheaper choice for the treatment of allergic rhinitis. Herbal patches at acupoints and endonasal low level laser may meet the needs. Our study combined the treatment of both low level laser and herbal patches at acupoints for allergic rhinitis . We have all ready known that either low level laser or herbal patches can be effective for the treatment of allergic rhinitis. The effect of combination of the both treatment modalities has not yet been known. Method: We combine these two effective, noninvasive treatment and compare the effect with single treatment. Patients affected with allergic rhinitis which are included in this study are divided into three groups: herbal patches attached at acupoint; endonasal low level laser , and treatment with combinational therapy. Herbal patches were attached everyday and last for 20 days. Low level laser was applied at nasal mucosa every 3 days and total 10 times as a course with 20 minutes each time. Patients fill the score of Nasal Symptom Scoring Criteria. Results :During Jan 2007 to Jan 2008 total 60 patients are included and 20 patients within each group. Treatment effect of each group was compared by paired-t Test , and revealed that all three were effective (p=0.000 <0.005 two tails). The effect within each group was compared by one-way ANOVA study and didn''t show any difference( F=1.622; p= 0.206>0.05). The improvement of nasal stuffness degree was compared by one- way ANOVA study and showed no difference either( F=0.606; p= 0.549>0.05) . Conclusion: The conclusion is that all these treatment are effective but can''t tell significant difference of effectiveness between them.

Conclusions. SBL showed its efficacy in treating the animal model of allergic rhinitis. Its mechanisms may be related to its suppressive action on PCA reaction, the production of TXB2 and the expression of eNOS, as well as its modulation of cytokines, including IL-4, IL-6, IL-8, GM-CSF and TNF-alpha, release from mast cells. The clinical trial showed that SBL had more beneficial action on the quality of life, in comparison to the placebo, in the domains of RE and BP. Some symptoms evaluations of PAR patients, including GF, NB and SF were more markedly improved in the SBL group when compared with the placebo group. Furthermore, the use of SBL, with the study dose and treatment period, was safe. However, the accurate efficacy and mechanisms of SBL are largely unknown and need further investigation. (Abstract shortened by UMI.)
Introduction. Although great progress in treatment of allergic rhinitis have made in recent years, remarkably increasing prevalence and cost in epidemiology studies strongly suggest the difficulties in the management of allergic rhinitis. Shi-Bi-Lin (SBL) is a formula modified from the traditional Chinese herbal formula Cang-Er-Zi-San (CEZS) and a classic European formula SinupretRTM. CEZS has been used for the treatment of allergic rhinitis for several centuries in East Asia communities, and SinupretRTM has been used in treating paranasal sinusitis and rhinitis widely in Europe for decades. However, its therapeutic mechanisms remain unclear. We examined the efficacy and the possible mechanism of SBL in an animal model of allergic rhinitis and in cell culture study using Human Mast Cell Line (HMC-1) and Peripheral Blood Mononuclear Cells (PBMC). In addition, a clinical trial was conducted to examine its clinical efficacy and safety.
Results. In the animal study, SBL showed a potent effect in relieving the symptoms of nasal obstruction, sneezing and nasal scratching (P<0.05 or P<0.01), but had no convincing effect in decreasing the nasal discharge (P>0.05). In PCA test, IgG1 increased in a modest manner in the SBL-treated group when compared with the sham group (P<0.05 or P<0.01). Eosinophil infiltration and the expression of eNOS in nasal mucosa, but not iNOS, were obviously lower in the SBL treated group (P<0.05 or P<0.01) in comparison to the sham group. The levels of thromboxane B (TXB)2 in the nasal lavage fluid, but not histamine and peptide leukotrienes (p-LTs), showed significantly lower than that of the sham group (P<0.05). In vitro study showed that SBL modulated the cytokines, including interleukin (IL)-4, IL-6, IL-8, Granulocyte/Macrophage Colony-Stimulating Factor (GM-CSF) and tumor necrosis factor (TNF)-alpha, release from human mast cell line (HMC-1). However, the mRNA expressions of these cytokines were not significantly altered. As the controls, dexamethasone, desloratadine and budesonide had more potently inhibitory effects on cytokines release from HMC-1. The component herbs generally had stimulatory effects on the cytokine release from HMC-1 and variable effects on PBMC. In the clinical trial, a total of 84 patients were recruited in the clinical trial and 77 of them completed the trial. Although no significant differences of each domain between the SBL and placebo groups were detected, findings supported the efficacy of SBL were obtained.
by Zhao Yu.
"July 2005."
Advisers: C. A. Van Hasselt; Ping-Chung Leung; Kong-Sang Woo.
Source: Dissertation Abstracts International, Volume: 67-01, Section: B, page: 0172.
Thesis (Ph.D.)--Chinese University of Hong Kong, 2005.
Includes bibliographical references.
Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web.
Electronic reproduction. [Ann Arbor, MI] : ProQuest Information and Learning, [200-] System requirements: Adobe Acrobat Reader. Available via World Wide Web.
Abstract in English and Chinese.
School code: 1307.

碩士
義守大學
管理學院管理碩士在職專班
100
Since 1998 the income has been smaller than the expenditure appears, among them medicines consume rising from 64 billion in1997 to 1322 billion in 2009. In order to resolve the financial problems, the NHI implemented '' Pharmaceutical Benefit Scheme for National Health Insurance”(PBS) and “Guidelines of price adjustment for National Health Insurance reimbursed drugs” in Mar 30 and Apr 28 of 1999. Allergic rhinitis is a common disease in Taiwan; studies indicated that prevalence increases over time. In Taiwan the prevalence of Allergic rhinitis is about 20%, therefore the expense of the public health resources for allergic rhinitis should be concern. This project aims to investigate the impact of drug reimbursement policies on prescription of brand and generic antihistamine drugs in patients with Allergic rhinitis. Health care claim data from the National Health Insurance (NHI) program during the period 2002-2009, and the ATC 7-digit coding system of NHI Pharmaceutical Subsidy was used as the interface for analyzing the pharmaceutical claim data. In this study, 260,607 cases with allergic rhinitis analysis and prescription of antihistamine drugs were enrolled and analyses, among them 125,713 cases were female and 134,894 were male (data enrollment from 5 medical centers, BNHI southern and KAO-PING Branch). The analytic tools were Microsoft Excel and SPSS 12.0. Results indicated that from 2002 to 2009, the visits and prescription of antihistamine due to allergic rhinitis were decrease over time. Speciality analyze indicated that number of male is higher than of woman, age between 37 to 56 yr. The average visit times of patients were higher in private medica center than public center. The affect of Drug Reimbursement Policy on brand and generic antihistamine drugs prescription behavior were significant, of which the prescription quantity and amount of generic antihistamine drugs were increase and of brand antihistamine drugs were decrease over time. Distinguish by type of medical center revealed that private medical center tend to prescription of generic antihistamine drugs, but public medical center tend to prescription of brand antihistamine drugs. In order to improve the financial problems, several policies were implemented by BNHI, include Global Budget System, drug payment price adjustment and Drug Reimbursement Policy. However, the healthcare quality and therapeutic effect were not considerate when these policies implemented. Thus it makes medical sponsor choose generic drugs to obtain higher discount rate and profit. Although these policies makes the pharmaceutical cost maintain at 25% of total medical budget, but the potential medical expenditure can't be assessed when prescription behavior change. We therefore suggest that, relevant organization should revise these policies to make the medical resources distribution and payment system more reasonable and healthcare quality improvement.