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Journal articles on the topic 'Homère (Homerus)'

Author: Grafiati

Published: 4 June 2021

Last updated: 5 February 2022

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1

Reibring, Claes-Göran, Kristina Hallberg, Anders Linde, and Amel Gritli-Linde. "Distinct and Overlapping Expression Patterns of the Homer Family of Scaffolding Proteins and Their Encoding Genes in Developing Murine Cephalic Tissues." International Journal of Molecular Sciences 21, no. 4 (February 13, 2020): 1264. http://dx.doi.org/10.3390/ijms21041264.

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In mammals Homer1, Homer2 and Homer3 constitute a family of scaffolding proteins with key roles in Ca2+ signaling and Ca2+ transport. In rodents, Homer proteins and mRNAs have been shown to be expressed in various postnatal tissues and to be enriched in brain. However, whether the Homers are expressed in developing tissues is hitherto largely unknown. In this work, we used immunohistochemistry and in situ hybridization to analyze the expression patterns of Homer1, Homer2 and Homer3 in developing cephalic structures. Our study revealed that the three Homer proteins and their encoding genes are expressed in a wide range of developing tissues and organs, including the brain, tooth, eye, cochlea, salivary glands, olfactory and respiratory mucosae, bone and taste buds. We show that although overall the three Homers exhibit overlapping distribution patterns, the proteins localize at distinct subcellular domains in several cell types, that in both undifferentiated and differentiated cells Homer proteins are concentrated in puncta and that the vascular endothelium is enriched with Homer3 mRNA and protein. Our findings suggest that Homer proteins may have differential and overlapping functions and are expected to be of value for future research aiming at deciphering the roles of Homer proteins during embryonic development.

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2

Son, Aran, Namju Kang, Sue Young Oh, Ki Woo Kim, Shmuel Muallem, Yu-Mi Yang, and Dong Min Shin. "Homer2 and Homer3 modulate RANKL-induced NFATc1 signaling in osteoclastogenesis and bone metabolism." Journal of Endocrinology 242, no. 3 (September 2019): 241–49. http://dx.doi.org/10.1530/joe-19-0123.

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The receptor activator of nuclear factor-kappa B ligand (RANKL) induces osteoclastogenesis by induction of Ca2+ oscillation, calcineurin activation and translocation into the nucleus of nuclear factor of activated T cells type c1 (NFATc1). Homer proteins are scaffold proteins. They regulate Ca2+ signaling by modulating the activity of multiple Ca2+ signaling proteins. Homers 2 and 3, but not Homer1, also independently affect the interaction between NFATc1 and calcineurin. However, to date, whether and how the Homers are involved in osteoclastogenesis remains unknown. In the present study, we investigated Homer2 and Homer3 roles in Ca2+ signaling and NFATc1 function during osteoclast differentiation. Deletion of Homer2/Homer3 (Homer2/3) markedly decreased the bone density of the tibia, resulting in bone erosion. RANKL-induced osteoclast differentiation is greatly facilitated in Homer2/3 DKO bone marrow-derived monocytes/macrophages (BMMs) due to increased NFATc1 expression and nuclear translocation. However, these findings did not alter RANKL-induced Ca2+ oscillations. Of note, RANKL treatment inhibited Homer proteins interaction with NFATc1, but it was restored by cyclosporine A treatment to inhibit calcineurin. Finally, RANKL treatment of Homer2/3 DKO BMMs significantly increased the formation of multinucleated cells. These findings suggest a novel potent mode of bone homeostasis regulation through osteoclasts differentiation. Specifically, we found that Homer2 and Homer3 regulate NFATc1 function through its interaction with calcineurin to regulate RANKL-induced osteoclastogenesis and bone metabolism.

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3

Zhu, Man, Jiangcheng Zuo, Ji Shen, Wei Jing, Ping Luo, Nandi Li, Xue Wen, et al. "Diagnostic Potential of Differentially Expressed Homer1 and Homer2 in Ischemic Stroke." Cellular Physiology and Biochemistry 39, no. 6 (2016): 2353–63. http://dx.doi.org/10.1159/000447927.

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Background: Ischemic stroke (IS) is an extremely heterogeneous disease with variable pathogenesis. Due to the lack of early diagnostic marker, the mortality rate of IS remains high worldwide. The family of Homer plays an important role in the pathology of atherosclerotic plaque. In this study, we have investigated its expression pattern and clinical significance in IS. Methods: RT-qPCR was performed to detect the expression of Homer1, Homer2, and Homer3. Results: We found that the mRNA levels of Homer1 (p<0.001) and Homer2 (p<0.001), but not Homer3, in large-artery atherosclerosis (LAA) strokes were significantly upregulated than those in non-LAA strokes and controls. Multinomial logistic regression analyses showed that, although none of the Homer was associated with non-LAA strokes, higher Homer1 (adjusted OR=1.337, 95% CI: 1.227-1.458) and Homer2 (adjusted OR=1.099, 95% CI: 1.062-1.138) levels showed significant associations with increased odds of having LAA stroke, compared with the controls. The receiver operating characteristic (ROC) curves showed that the combination of Homer1 and Homer2 had a better diagnostic accuracy to differentiate LAA strokes from non-LAA strokes and controls, and the sensitivity and specificity ratios were 80.5%/90.4% and 98.0%/70.3%, respectively. Conclusion: Our data suggested that Homer1 and Homer2 might be considered as novel diagnostic biomarkers for LAA stroke.

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4

Reshetnikov, Vasiliy V., and Natalia P. Bondar. "The Role of Stress-Induced Changes of Homer1 Expression in Stress Susceptibility." Biochemistry (Moscow) 86, no. 6 (June 2021): 613–26. http://dx.doi.org/10.1134/s0006297921060018.

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Abstract Stress negatively affects processes of synaptic plasticity and is a major risk factor of various psychopathologies such as depression and anxiety. HOMER1 is an important component of the postsynaptic density: constitutively expressed long isoforms HOMER1b and HOMER1c bind to group I metabotropic glutamate receptors MGLUR1 (GRM1) and MGLUR5 and to other effector proteins, thereby forming a postsynaptic protein scaffold. Activation of the GLUR1–HOMER1b,c and/or GLUR5–HOMER1b,c complex regulates activity of the NMDA and AMPA receptors and Ca2+ homeostasis, thus modulating various types of synaptic plasticity. Dominant negative transcript Homer1a is formed as a result of activity-induced alternative termination of transcription. Expression of this truncated isoform in response to neuronal activation impairs interactions of HOMER1b,c with adaptor proteins, triggers ligand-independent signal transduction through MGLUR1 and/or MGLUR5, leads to suppression of the AMPA- and NMDA-mediated signal transmission, and thereby launches remodeling of the postsynaptic protein scaffold and inhibits long-term potentiation. The studies on animal models confirm that the HOMER1a-dependent remodeling most likely plays an important part in the stress susceptibility, whereas HOMER1a itself can be regarded as a neuroprotector. In this review article, we consider the effects of different stressors in various animal models on HOMER1 expression as well as impact of different HOMER1 variants on human behavior as well as structural and functional characteristics of the brain.

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5

Shin, Dong Min, Marlin Dehoff, Xiang Luo, Shin Hyeok Kang, Jiangchen Tu, Surendra K. Nayak, Elliott M. Ross, Paul F. Worley, and Shmuel Muallem. "Homer 2 tunes G protein–coupled receptors stimulus intensity by regulating RGS proteins and PLCβ GAP activities." Journal of Cell Biology 162, no. 2 (July 8, 2003): 293–303. http://dx.doi.org/10.1083/jcb.200210109.

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Homers are scaffolding proteins that bind G protein–coupled receptors (GPCRs), inositol 1,4,5-triphosphate (IP3) receptors (IP3Rs), ryanodine receptors, and TRP channels. However, their role in Ca2+ signaling in vivo is not known. Characterization of Ca2+ signaling in pancreatic acinar cells from Homer2−/− and Homer3−/− mice showed that Homer 3 has no discernible role in Ca2+ signaling in these cells. In contrast, we found that Homer 2 tunes intensity of Ca2+ signaling by GPCRs to regulate the frequency of [Ca2+]i oscillations. Thus, deletion of Homer 2 increased stimulus intensity by increasing the potency for agonists acting on various GPCRs to activate PLCβ and evoke Ca2+ release and oscillations. This was not due to aberrant localization of IP3Rs in cellular microdomains or IP3R channel activity. Rather, deletion of Homer 2 reduced the effectiveness of exogenous regulators of G proteins signaling proteins (RGS) to inhibit Ca2+ signaling in vivo. Moreover, Homer 2 preferentially bound to PLCβ in pancreatic acini and brain extracts and stimulated GAP activity of RGS4 and of PLCβ in an in vitro reconstitution system, with minimal effect on PLCβ-mediated PIP2 hydrolysis. These findings describe a novel, unexpected function of Homer proteins, demonstrate that RGS proteins and PLCβ GAP activities are regulated functions, and provide a molecular mechanism for tuning signal intensity generated by GPCRs and, thus, the characteristics of [Ca2+]i oscillations.

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6

Urdánoz-Casado, Amaya, Javier Sánchez-Ruiz de Gordoa, Maitane Robles, Blanca Acha, Miren Roldan, María Victoria Zelaya, Idoia Blanco-Luquin, and Maite Mendioroz. "Gender-Dependent Deregulation of Linear and Circular RNA Variants of HOMER1 in the Entorhinal Cortex of Alzheimer’s Disease." International Journal of Molecular Sciences 22, no. 17 (August 26, 2021): 9205. http://dx.doi.org/10.3390/ijms22179205.

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The HOMER1 gene is involved in synaptic plasticity, learning and memory. Recent studies show that circular RNA derived from HOMER1 (circHOMER1) expression is altered in some Alzheimer’s disease (AD) brain regions. In addition, HOMER1 messenger (mRNA) levels have been associated with β-Amyloid (Aβ) deposits in brain cortical regions. Our aim was to measure the expression levels of HOMER1 circRNAs and their linear forms in the human AD entorhinal cortex. First, we showed downregulation of HOMER1B/C and HOMER1A mRNA and hsa_circ_0006916 and hsa_circ_0073127 levels in AD female cases compared to controls by RT-qPCR. A positive correlation was observed between HOMER1B/C, HOMER1A mRNA, and hsa_circ_0073128 with HOMER1B/C protein only in females. Global average area of Aβ deposits in entorhinal cortex samples was negatively correlated with HOMER1B/C, HOMER1A mRNA, and hsa_circ_0073127 in both genders. Furthermore, no differences in DNA methylation were found in two regions of HOMER1 promoter between AD cases and controls. To sum up, we demonstrate that linear and circular RNA variants of HOMER1 are downregulated in the entorhinal cortex of female patients with AD. These results add to the notion that HOMER1 and its circular forms could be playing a female-specific role in the pathogenesis of AD.

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7

Parisiadou, Loukia, Ioanna Bethani, Vasiliki Michaki, Kaliopi Krousti, Georgia Rapti, and Spiros Efthimiopoulos. "Homer2 and Homer3 interact with amyloid precursor protein and inhibit Aβ production." Neurobiology of Disease 30, no. 3 (June 2008): 353–64. http://dx.doi.org/10.1016/j.nbd.2008.02.004.

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8

Ary, A. W., K. D. Lominac, M. G. Wroten, A. R. Williams, R. R. Campbell, O. Ben-Shahar, G. von Jonquieres, M. Klugmann, and K. K. Szumlinski. "Imbalances in Prefrontal Cortex CC-Homer1 versus CC-Homer2 Expression Promote Cocaine Preference." Journal of Neuroscience 33, no. 19 (May 8, 2013): 8101–13. http://dx.doi.org/10.1523/jneurosci.1727-12.2013.

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9

Ulf, Christoph. "Homer’s World oder die Welt Homers? Kontextualisierungen zur „Homer Encyclopedia“." Historische Zeitschrift 295, no. 1 (September 2012): 105–17. http://dx.doi.org/10.1524/hzhz.2012.0354.

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10

Makondi, Precious Takondwa. "The role of HOMER3 in liver cancer progression." Journal of Global Oncology 5, suppl (October 7, 2019): 89. http://dx.doi.org/10.1200/jgo.2019.5.suppl.89.

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89 Background: Liver cancer (LC) is in the seventh most common cancer and the fourth largest cause of cancer deaths. Although significant progress has been made in the prevention and treatment of viral hepatitis; alcoholic liver disease, obesity and diabetes are now emerging as major causes for LC. Recently there has been increase in identification of biomarkers which can predict LC risk and disease progression, but the roles of HOMER3 gene in LC are not known. Methods: First the expression of HOMER3 between normal and tumor tissues was determined using The Cancer Genome Atlas (TCGA), Genetic Expression Omnibus (GEO) and protein atlas datasets. HOMER3 expression at different clinical stage and overall survival (OS) was also determined. The role of HOMER3 on OS in relation to cancer stage, hepatitis virus infection and alcohol intake was also determined. STRING database determined HOMER3 interaction network and TCGA was used to verify the correlation status, and the roles of the network genes on OS. The pathways enriched by HOMER3 were determined by Gene Set Enrichment Analysis (GSEA). Results: HOMER3 was significantly highly expressed in tumor tissues as compared to normal tissues. The expression of HOMER3 correlated positively with clinical stage, with highest expression in advanced stages (Stage 3 and 4), and high HOMER3 expression was associated with poor OS. HOMER3’ s high expression was associated with poor OS in advanced stage, alcohol intake, and in those negative of viral hepatitis infection. HOMER3 interacted with HOMER1, SHANK1, GRM5, GRM1, DLGAP1, SHANK2, DLG4, SHANK3, DLG2 and DLGAP4, with positive correlation to HOMER1, SHANK1, GRM5, GRM1, DLGAP1, DLG4 and DLGAP4 and negative correlation to SHANK2, SHANK3 and DLG2. HOMER1 and DLGAP4 high expression were associated with poor OS while SHANK2, SHANK3 and DLG2 high expression were associated with favorable OS. GRM5 and GRM1 high expression were associated with favorable OS despite being positively correlated with HOMER3. ECM receptor interaction and Notch signaling were the upregulated pathways while Metabolism of xenobiotics by cytochrome p450 and PPAR signaling were the downregulated pathways. Conclusions: HOMER3 may is have a role in liver cancer progression of which its targeting may improve LC outcome.

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11

Gould, Adam T., Arianne D. Sacramento, Melissa G. Wroten, Bailey W. Miller, Georg von Jonquieres, Matthias Klugmann, Osnat Ben-Shahar, and Karen K. Szumlinski. "Cocaine-elicited imbalances in ventromedial prefrontal cortex Homer1 versus Homer2 expression: implications for relapse." Addiction Biology 20, no. 1 (September 30, 2013): 148–57. http://dx.doi.org/10.1111/adb.12088.

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12

Kang, Jung Yun, Namju Kang, Dong Min Shin, and Yu-Mi Yang. "Deficiencies of Homer2 and Homer3 accelerate aging-dependent bone loss in mice." International Journal of Oral Biology 45, no. 3 (September 30, 2020): 126–33. http://dx.doi.org/10.11620/ijob.2020.45.3.126.

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13

Luo, Ping, Chunzi Liang, Wei Jing, Man Zhu, Hu Zhou, Hongyan Chai, Paul F. Worley, and Jiancheng Tu. "Homer2 and Homer3 Act as Novel Biomarkers in Diagnosis of hepatitis B virus-induced Hepatocellular Carcinoma." Journal of Cancer 12, no. 12 (2021): 3439–47. http://dx.doi.org/10.7150/jca.52118.

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14

Dowden, Ken. "Homer's sense of text: Homeric ‘Text’, Cyclic ‘Text’." Journal of Hellenic Studies 116 (November 1996): 47–61. http://dx.doi.org/10.2307/631955.

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In this article I am concerned to form a view of the interaction of Homer's Iliad with other texts prior to his. This is an issue whose legitimacy, particularly in English-language scholarship, has been rather obscured by scholarly discourse in terms of oral poetics, an issue I shall discuss presently. Yet, unless they are completely new fictions, the Cyclic epics do show us some of the material with which Homer was bound to be interacting, and it has been the achievement of the Neoanalysts to detail that interaction. In the following I do not claim to add greatly to the repertoire of neoanalytic data, but I do hope to build on it some sense of Homer's achievement in this area and to make clear our entitlement to respond to Homer's intertextuality.

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15

Piasecki, Dariusz. "Eucharystia u Homera?" Vox Patrum 69 (December 16, 2018): 561–72. http://dx.doi.org/10.31743/vp.3275.

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The article attempts to answer the question: is it possible to represent the Last Supper of Jesus and His Apostles by means of verses selected from Homer’s Iliad and the Odyssey. The Homeric Cento no. 40, which emphasizes the community of Christ’s table with His disciples, has been a subject of my analysis. The specific selection of Homeric verses, with some minor modifications, allowed the centonist to construct a new text with a completely different context and content, reflecting both the reality of the Upper Room and the establishment of the Eucharist by Jesus.

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16

Seiberth, Volker. "Die Blindheit Homers." Klinische Monatsblätter für Augenheilkunde 235, no. 02 (October 25, 2017): 219–22. http://dx.doi.org/10.1055/s-0041-105822.

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17

Latacz, Joachim. "Fragen an Homers Achilleus." Philologia Classica 13, no. 1 (2018): 9–25. http://dx.doi.org/10.21638/11701/spbu20.2018.101.

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18

Jardin, Isaac, Letizia Albarrán, Nuria Bermejo, Ginés M. Salido, and Juan A. Rosado. "Homers regulate calcium entry and aggregation in human platelets: a role for Homers in the association between STIM1 and Orai1." Biochemical Journal 445, no. 1 (June 15, 2012): 29–38. http://dx.doi.org/10.1042/bj20120471.

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Homer is a family of cytoplasmic adaptor proteins that play different roles in cell function, including the regulation of G-protein-coupled receptors. These proteins contain an Ena (Enabled)/VASP (vasodilator-stimulated phosphoprotein) homology 1 domain that binds to the PPXXF sequence motif, which is present in different Ca2+-handling proteins such as IP3 (inositol 1,4,5-trisphosphate) receptors and TRPC (transient receptor potential canonical) channels. In the present study we show evidence for a role of Homer proteins in the STIM1 (stromal interaction molecule 1)–Orai1 association, as well as in the TRPC1–IP3RII (type II IP3 receptor) interaction, which might be of relevance in platelet function. Treatment of human platelets with thapsigargin or thrombin results in a Ca2+-independent association of Homer1 with TRPC1 and IP3RII. In addition, thapsigargin and thrombin enhanced the association of Homer1 with STIM1 and Orai1 in a Ca2+-dependent manner. Interference with Homer function by introduction of the synthetic PPKKFR peptide into cells, which emulates the proline-rich sequences of the PPXXF motif, reduced STIM1–Orai1 and TRPC1– IP3RII associations, as compared with the introduction of the inactive PPKKRR peptide. The PPKKFR peptide attenuates thrombin-evoked Ca2+ entry and the maintenance of thapsigargin-induced store-operated Ca2+ entry. Finally, the PPKKFR peptide attenuated thrombin-induced platelet aggregation. The findings of the present study support an important role for Homer proteins in thrombin-stimulated platelet function, which is likely to be mediated by the support of agonist-induced Ca2+ entry.

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19

Nguyen, Viet Hung. "ARTISTS CHANTING - NARRATING EPIC POEMS PROFESSIONAL OR UNPROFESSIONAL?" UED Journal of Social Sciences, Humanities and Education 10, Special (September 27, 2020): 62–69. http://dx.doi.org/10.47393/jshe.v10ispecial.881.

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Homer’s creative works Iliad, Odyssey have undergone a history of thousands of years, but the Homeric issues have never ceased to be new to generations of researchers. There still remain unanswered questions: Was Homer a professional writer or a folk artist? Did his epical compositions belong to the written or oral literary genre? Were Homer's poems the works of a single poet or of many contributors? We refer to Homer as an artist, a collector and compiler of Greek epics in relation to the type of epic artists in Vietnam. A study of the artists chanting-narrating epic poems from various perspectives: society - profession (professional or amateur?), mode of artistic creation (folk or scholarly?), the relationship between performance and context (ritualistic or non-ritualistic?) ... will clarify the characteristics of the artists chanting - narrating epic poems and the nature of the artistic creation process, and probably put forward suggestions for the preservation of the epic repertoire of ethnic groups.

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20

Alfaro Molina, Juan Gabriel. "El daímon homérico como antecedente del concepto filosófico de felicidad (eudaimonía)." Thémata Revista de Filosofía, no. 63 (2021): 321–38. http://dx.doi.org/10.12795/themata.2021.i63.16.

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La felicidad (eudaimonía) es un concepto central en los escritos éticos filosóficos. Aquí se presenta un estudio sobre como los principales escritos homéricos fundamentan el sentido de este término, donde, a pesar de desconocerse dicha noción, utiliza la palabra compuesta de buen (εὐ) y daímon (δαίμων) para indicar la presencia de un ser celestial que guía al individuo. Homero en sus obras utiliza una serie de fórmulas para describir a este daímon, y cómo este se fue identificando como algo cercano a la conciencia del hombre, una acción divina en el interior de cada ser humano.

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21

Holoka, James P., and Effie N. Coughanowr. "Herodoti Vita Homeri." Classical World 85, no. 3 (1992): 244. http://dx.doi.org/10.2307/4351075.

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22

Portulas, Jaume. "De Vita Homeri." Mètis. Anthropologie des mondes grecs anciens 9, no. 1 (1994): 351–57. http://dx.doi.org/10.3406/metis.1994.1037.

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23

González Álvaro, María Luisa. "Homero en la teoría literaria española del Siglo de Oro." Estudios Humanísticos. Filología, no. 19 (December 15, 1997): 33. http://dx.doi.org/10.18002/ehf.v0i19.4055.

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<p><span class="titulo">En las páginas siguientes se tratará de desenterrar la figura de Homero, sepultada bajo el aluvión de citas y referencias de todo tipo (artísticas, históricas, filosóficas...) que frecuentan las páginas de nuestra teoría literaria del Siglo de Oro. Se han escogido varias obras fechadas a fines del XVI y principios del XVII por su importancia y representatividad. Con ellas como base se han intentado organizar, clasificar y analizar las menciones que al poeta griego y a diferentes aspectos de su obra allí se han localizado. Partiendo del inmenso prestigio del que gozaba la figura de Homero, se ha considerado de interés establecer, de alguna manera, distintos puntos clave en torno a los cuales se centra esa gran consideración, es decir, las cuestiones más relevantes en las que, para estos preceptistas, Homero aparece como la máxima autoridad.</span></p><p><span class="titulo">The aim of this paper is to unearth Homer from the immense amount of quotations and referentes of all kinds (artistic, historical, philosophical) so common in the papes of our literary theory of the Golden Century. Several works, dating from the end of the XVI century and the beginning of the XVII century have been chosen because of their importante and typical nature. Using them as a base, we have tried to organise and analyse the mentions to the Greek poet and his works. Taking Homer's immense prestige as a starting point, we have considered of interest to establish the different key points around which this prestige thrives, that is to say, the most relevant issues in which, according to the theorists, Homer was considered the highest authority.</span></p>

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24

Torres-Guerra, José B. "El Homero de Jenófanes." Emerita 67, no. 1 (June 30, 1999): 75–86. http://dx.doi.org/10.3989/emerita.1999.v67.i1.186.

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25

Foulon, Eric. "Ulrich von Wilamowitz-Moellendorf, Homers Ilias." Anabases, no. 8 (October 1, 2008): 312–15. http://dx.doi.org/10.4000/anabases.276.

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26

Assunção, Teodoro Rennó. "Annotations sur le mépris de Godard et l’Odyssée d'"Homère"." Revista Archai, no. 7 (2011): 109–14. http://dx.doi.org/10.14195/1984-249x_7_10.

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27

Giangrande, Giuseppe. "Un problema etimológico en Homero." Emerita 61, no. 1 (June 30, 1993): 135. http://dx.doi.org/10.3989/emerita.1993.v61.i1.460.

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28

Negus, Kevin J., John Waters, Jean Tourrilhes, Chris Romans, Jim Lansford, and Stephen Hui. "HomeRF™ and SWAP." ACM SIGMOBILE Mobile Computing and Communications Review 2, no. 4 (October 1998): 28–37. http://dx.doi.org/10.1145/1321400.1321401.

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29

Garner, Bob. "Is homers’ odd essay into nursing legal?" Nursing Standard 8, no. 12 (December 8, 1993): 42. http://dx.doi.org/10.7748/ns.8.12.42.s56.

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30

Donath, Ruth. "Adverb, Präposition, Präverb in der Sprache Homers." WIENER STUDIEN Zeitschrift für Klassische Philologie, Patristik und lateinische Tradition 1, no. 117 (2004): 5–14. http://dx.doi.org/10.1553/wst117s5.

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31

Dumont, JacquesE, and J. van Sande. "Specificity in signaling and modulators: the Homers." Trends in Cell Biology 12, no. 1 (January 2002): 9. http://dx.doi.org/10.1016/s0962-8924(01)02216-4.

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32

Orr, M. "Review: Desirs d'hospitalite: de Homere a Kafka." French Studies 58, no. 1 (January 1, 2004): 145–46. http://dx.doi.org/10.1093/fs/58.1.145.

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33

Sullivan, Shirley Darcus. "The Psychic Term ἦτορ: ¡ts nature and relation to person in Homer and the Homeric Hymns." Emerita 64, no. 1 (June 30, 1996): 11–29. http://dx.doi.org/10.3989/emerita.1996.v64.i1.244.

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34

Abry, Nicolas. "The Woodcutter As the Living Force of a Homer’s Cyber-Brain, Still Incognito." IRIS, no. 36 (June 30, 2015): 121–38. http://dx.doi.org/10.35562/iris.1595.

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Il est assez commun de se représenter le bûcheron comme un être plutôt fruste, qualifié avant tout par sa force au service d’une tâche peu valorisée. Or cette représentation se révèle tronquée, car l’équation qui associe la force à l’outil ne peut se réaliser sans le contrôle du geste. Plus encore, l’écoute des témoignages recueillis auprès des forestiers nous apprend que ce travail réclame d’efficaces systèmes de précision. C’est là une qualification oubliée, pourtant reconnue à part entière dès l’Iliade, qui nous en donne deux témoins privilégiés par l’anthropologie historique de la Grèce, la mètis, l’« intelligence rusée », prêtée au kybérnêtês, le pilote du navire (éponyme de la cybernétique ou science du contrôle), au conducteur de char et, en bonne première place, au bûcheron. La théorie du contrôle nous permet maintenant de dépasser le flou conceptuel de la notion historiquement pré-théorique de mètis, la ruse s’appliquant à des cas bien trop divers, pour lui préférer les développements les plus récents d’une science du contrôle de l’action, théorisée depuis Wiener, nourrissant aujourd’hui les projets les mieux financés de cyber-cerveaux informatiques, au service des neurosciences et de la médecine (qui sont les domaines finalement retenus [au 19 mars 2015] dans l’expertise sur la gouvernance disputée du Human Brain Project, hautement financé par l’Europe [parti de l’École polytechnique fédérale, Lausanne]). Le travail forestier (abattage et débardage), qui réclame une coordination maîtrisée des gestes, y compris de leurs commandes vocales dans le chant de travail — qu’un seul ou plusieurs bûcherons en équipe soient mobilisés —, nous en fournit une parfaite illustration.

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Abry, Nicolas. "The Woodcutter As the Living Force of a Homer’s Cyber-Brain, Still Incognito." IRIS, no. 36 (June 30, 2015): 121–38. http://dx.doi.org/10.35562/iris.1595.

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Il est assez commun de se représenter le bûcheron comme un être plutôt fruste, qualifié avant tout par sa force au service d’une tâche peu valorisée. Or cette représentation se révèle tronquée, car l’équation qui associe la force à l’outil ne peut se réaliser sans le contrôle du geste. Plus encore, l’écoute des témoignages recueillis auprès des forestiers nous apprend que ce travail réclame d’efficaces systèmes de précision. C’est là une qualification oubliée, pourtant reconnue à part entière dès l’Iliade, qui nous en donne deux témoins privilégiés par l’anthropologie historique de la Grèce, la mètis, l’« intelligence rusée », prêtée au kybérnêtês, le pilote du navire (éponyme de la cybernétique ou science du contrôle), au conducteur de char et, en bonne première place, au bûcheron. La théorie du contrôle nous permet maintenant de dépasser le flou conceptuel de la notion historiquement pré-théorique de mètis, la ruse s’appliquant à des cas bien trop divers, pour lui préférer les développements les plus récents d’une science du contrôle de l’action, théorisée depuis Wiener, nourrissant aujourd’hui les projets les mieux financés de cyber-cerveaux informatiques, au service des neurosciences et de la médecine (qui sont les domaines finalement retenus [au 19 mars 2015] dans l’expertise sur la gouvernance disputée du Human Brain Project, hautement financé par l’Europe [parti de l’École polytechnique fédérale, Lausanne]). Le travail forestier (abattage et débardage), qui réclame une coordination maîtrisée des gestes, y compris de leurs commandes vocales dans le chant de travail — qu’un seul ou plusieurs bûcherons en équipe soient mobilisés —, nous en fournit une parfaite illustration.

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Colombani, Maria Cecilia. "Las marcas de la paideia en Homero. Banquete, palabra e identidad: los tópicos de las lecciones." Humanitas 66 (December 10, 2014): 9–21. http://dx.doi.org/10.14195/2183-1718_66_1.

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El proyecto del presente trabajo consiste en pensar la dimensión educativa en Homero. Entendemos que tanto en Ilíada como en Odisea aparecen elementos suficientes para poder ubicar a Homero en el lugar de un educador, tarea que la crítica ha realizado, sobre todo en torno a la educación aristocrática de la que Ilíada parece ser un ejemplo emblemático. Nuestro intento es ubicarnos en un plano nítidamente antropológico para ver cómo la paideia transita un andarivel que sitúa las relaciones entre los hombres y los dioses y los hombres entre sí como planos diferenciados que dan cuenta de un modelo de instalación ético-antropológica que constituye el núcleo mismo de la paideia como empresa moral. Se trata entonces de rastrear una determinada constitución subjetiva que incluye dos topoi de consideración, las relaciones entre mortales e Inmortales, como forma de habilitar el espacio que los hombres habrán de ocupar, y las relaciones intersubjetivas, como modo de territorializar los vínculos en el universo personal.http://dx.doi.org/10.14195/2183-1718_66_1

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Ferdous, Mafruha. "Reading Homer’s The Iliad in 21st Century." Advances in Language and Literary Studies 8, no. 2 (April 30, 2017): 101. http://dx.doi.org/10.7575/aiac.alls.v.8n.2p.101.

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Homer's Iliad refers to an epic story written by the ancient Greek poet Homer, which makes an account of the most significant events that earmarked the very last days which defined the Trojan War and the Greek siege of the city of Troy. Troy was also known as Ilium, Ilion, or Ilois in the past. Having made to center around the events of the Trojan War, Homer’s Iliad is a work of art that paints to all of us interested in literature, what really happened in the past. The paper purposes to provide invaluable insights regarding the significance of Homer’s Iliad today and what it teaches us about poetry and the ancient culture of the Greeks.

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Cao, Lei, Ye Tian, Yi Jiang, Ge-Juan Zhang, Hui Lei, and Zheng-Li Di. "Down-Regulation of Homer1b/c Protects Against Chemically Induced Seizures Through Inhibition of mTOR Signaling." Cellular Physiology and Biochemistry 35, no. 4 (2015): 1633–42. http://dx.doi.org/10.1159/000373977.

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Background: Homer is a family of post synaptic density proteins functionally and physically attached to target proteins at proline-rich sequences. Reducing Homer1b/c expression has been shown in previous studies to be protective against excitotoxic insults, implicating Homer1b/c in the physiological regulation of aberrant neuronal excitability. Methods: To test the efficacy of a Homer1b/c reducing therapy for disorders with a detrimental hyperexcitability profile in mice, we used small interfere RNA (siRNA) to decrease endogenous Homer1b/c expression in mouse hippocampus. The baseline motor and cognitive behavior was measured by sensorimotor tests, Morris water maze and elevated plus maze tasks. The anti-epileptic effects of Homer1b/c knockdown were determined in two chemically induced seizure models induced by Picrotoxin (PTX) or pentylenetetrazole (PTZ) administration. Results: The results of sensorimotor tests, Morris water maze and elevated plus maze tasks showed that Homer1b/c reduction had no effect on baseline motor or cognitive behavior. In two chemically induced seizure models, mice with reduced Homerb/c protein had less severe seizures than control mice. Total Homer1b/c protein levels and seizure severity were highly correlated, such that those mice with the most severe seizures also had the highest levels of Homer1b/c. In addition, the phosphorylation of mammalian target of rapamycin (mTOR) and its target protein S6 was significantly inhibited in Homer1b/c down-regulated mice. Homer1b/c knockdown-induced inhibition of mTOR pathway was partially ablated by the metabotropic glutamate receptor 5 (mGluR5) agonist CHPG. Conclusion: Our results demonstrate that endogenous Homer1b/c is integral for regulating neuronal hyperexcitability in adult animals and suggest that reduction of Homer1b/c could protect against chemically induced seizures through inhibition mTOR pathway.

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West, M. "Homeri Ilias. H Van Thiel." Classical Review 48, no. 1 (January 1, 1998): 1–2. http://dx.doi.org/10.1093/cr/48.1.1.

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Letria, José Jorge. "A Homero o que é de Homero." Boletim de Estudos Clássicos, no. 59 (December 29, 2014): 11–12. http://dx.doi.org/10.14195/2183-7260_59_1.

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Clifton, Nicholas E., Darren Cameron, Simon Trent, Lucy H. Sykes, Kerrie L. Thomas, and Jeremy Hall. "Hippocampal Regulation of Postsynaptic Density Homer1 by Associative Learning." Neural Plasticity 2017 (2017): 1–11. http://dx.doi.org/10.1155/2017/5959182.

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Genes involved in synaptic plasticity, particularly genes encoding postsynaptic density proteins, have been recurrently linked to psychiatric disorders including schizophrenia and autism. Postsynaptic density Homer1 proteins contribute to synaptic plasticity through the competing actions of short and long isoforms. The activity-induced expression of shortHomer1isoforms,Homer1aandAnia-3, is thought to be related to processes of learning and memory. However, the precise regulation ofHomer1aandAnia-3with different components of learning has not been investigated. Here, we used in situ hybridization to quantify short and longHomer1expression in the hippocampus following consolidation, retrieval, and extinction of associative fear memory, using contextual fear conditioning in rats.Homer1aandAnia-3, but not longHomer1, were regulated by contextual fear learning or novelty detection, although their precise patterns of expression in hippocampal subregions were dependent on the isoform. We also show for the first time that the two short Homer1 isoforms are regulated after the retrieval and extinction of contextual fear memory, albeit with distinct temporal and spatial profiles. These findings support a role of activity-induced Homer1 isoforms in learning and memory processes in discrete hippocampal subregions and suggest that Homer1a and Ania-3 may play separable roles in synaptic plasticity.

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Danek, Georg. "Troilos und Lykaon. Ein Beitrag zur Intertextualität Homers." Geistes-, sozial- und kulturwissenschaftlicher Anzeiger 151 (2017): 5–54. http://dx.doi.org/10.1553/anzeiger151-1s5.

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Sullivan, Shirley Darcus, and Thomas Jahn. "Zum Wortfeld "Seele-Geist" in der Sprache Homers." Phoenix 45, no. 1 (1991): 66. http://dx.doi.org/10.2307/1088443.

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Szumlinski, Karen K., Alexis W. Ary, and Kevin D. Lominac. "Homers regulate drug-induced neuroplasticity: Implications for addiction." Biochemical Pharmacology 75, no. 1 (January 2008): 112–33. http://dx.doi.org/10.1016/j.bcp.2007.07.031.

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45

Böhme, Robert. "Homer Alpha 1." Emerita 54, no. 2 (December 30, 1986): 203–35. http://dx.doi.org/10.3989/emerita.1986.v54.i2.647.

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Antolín Sánchez, Javier. "Raíces griegas de la compasión cristiana." Estudio Agustiniano 46, no. 3 (September 6, 2021): 469–515. http://dx.doi.org/10.53111/estagus.v46i3.235.

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Somos intelectualmente herederos de los griegos, por eso podemos rastrear la idea de compasión cristiana en la cultura y filosofía griega; en esta primera parte nos centraremos en Homero. La compasión dentro de la tradición griega es una pasión o emoción, en cambio, dentro de la tradición cristiana es una virtud. La compasión no fue un concepto uniforme a lo largo de la antigüedad, sino que experimentó muchos cambios. Esta evolución se puede ver en Homero, pues hablaba de dos aspectos de ελεος, uno más emocional y otro transitivo de cercanía a todos los hombres. Posteriormente este sentimiento de simpatía universal o filantropía se convertirá en virtud.

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Linares Sánchez, Jorge J. "Los cimerios homéricos (Od. XI 11-19) y su presencia en la literatura grecolatina." Myrtia 34 (January 31, 2020): 23–39. http://dx.doi.org/10.6018/myrtia.411921.

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En el canto XI de la Odisea se incluye por primera vez una descripción del pueblo de los cimerios en el marco del relato de un viaje al mundo de los muertos. En este artículo realizamos un análisis comparativo del pasaje homérico y de diversos textos de la literatura grecolatina a fin de mostrar cómo, a partir de Homero, los cimerios se convirtieron en un elemento tradicional del tema. Para ello, explicamos las semejanzas y diferencias en cuanto a la presencia, denominación, características y ubicación de este pueblo mítico en cada texto con respecto al modelo homérico. In canto Odyssey XI a description of the Cimmerian people is included for the first time as part of a journey to the netherworld’s narrative. In this paper a comparative analysis of the Homeric passage and of various texts from Greek and Latin literature is carried out in order to show how, since Homer, the Cimmerians became a traditional motive of this theme. For that purpose, the similarities and differences produced in terms of the presence, name, characteristics and location of this mythical town have been explained in each text regarding the Homeric model.

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Finkelberg, Margalit. "Patterns of human error in Homer." Journal of Hellenic Studies 115 (November 1995): 15–28. http://dx.doi.org/10.2307/631641.

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It has become habitual to approach Homeric man's mental functioning with the categories used today, only to show how different this man was from the later Greek and, moreover, from the modern individual. The studies in Homer's mental terminology begun by Bruno Snell and other German scholars before World War II illustrate this tendency. Although the scholarly value of these studies, which have led us to realize that the Homeric vocabulary lacks terms explicitly designating the person as a whole, is incontestable, in everything concerning the better understanding of Homeric man their effect has been, paradoxically enough, rather negative. Indeed, insofar as such ideas as ‘self’, ‘soul’, ‘character’ are said to be irrelevant to Homer, and what is proposed instead is a loose conglomerate of the so-called ‘mental organs’, Homeric man is turned into an incognizable entity altogether estranged from everything understood as human today or in classical Greece. At the same time, the essential humanity of Homeric man is immediately felt by every reader of Homer, and the incompatibility of this experience with the image created by terminological speculations about Homeric man is strong enough to call in question the relevance of the results obtained through the terminological approach.

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Lopes, Antônio Orlando Dourado. "A força e o antropomorfismo dos deuses gregos: considerações sobre a religião dos poemas homéricos." Aletria: Revista de Estudos de Literatura 19, no. 3 (December 31, 2009): 11–27. http://dx.doi.org/10.17851/2317-2096.19.3.11-27.

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Resumo: Um rápido percurso pelos estudos recentes sobre a representação homérica dos deuses coloca em evidência a dificuldade, surgida já na antiguidade e experimentada ao longo de toda a recepção moderna da cultura grega, de se conciliar a dimensão ontológica com o antropomorfismo constitutivo dos deuses gregos. Neste estudo, pretendo mostrar que essas duas características se associaram na religião grega desde muito cedo e marcaram definitivamente sua relação com a literatura.Palavras-chave: Religião grega; Homero; antropomorfismo.Abstract: A rapid survey of the recent studies concerning the Homeric representation of the gods calls our atention to the difficulty, present already in antiquity and experienced during the whole modern reception of Greek culture, of accepting both the ontological dimension of the gods and their anthropomorphism. Recurring to recent bibliography I propose in this study that these two aspects were associated very early in Greek religion.Keywords: Homer, Greek religion, Anthropomorphism.

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Fjell, Anders M., Donatas Sederevicius, Markus H. Sneve, Ann-Marie Glasø de Lange, Anne CecilieSjøli Bråthen, Ane-Victoria Idland, Leiv Otto Watne, et al. "Self-reported Sleep Problems Related to Amyloid Deposition in Cortical Regions with High HOMER1 Gene Expression." Cerebral Cortex 30, no. 4 (November 11, 2019): 2144–56. http://dx.doi.org/10.1093/cercor/bhz228.

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Abstract Sleep problems are related to the elevated levels of the Alzheimer’s disease (AD) biomarker β-amyloid (Aβ). Hypotheses about the causes of this relationship can be generated from molecular markers of sleep problems identified in rodents. A major marker of sleep deprivation is Homer1a, a neural protein coded by the HOMER1 gene, which has also been implicated in brain Aβ accumulation. Here, we tested whether the relationship between cortical Aβ accumulation and self-reported sleep quality, as well as changes in sleep quality over 3 years, was stronger in cortical regions with high HOMER1 mRNA expression levels. In a sample of 154 cognitively healthy older adults, Aβ correlated with poorer sleep quality cross-sectionally and longitudinally (n = 62), but more strongly in the younger than in older individuals. Effects were mainly found in regions with high expression of HOMER1. The anatomical distribution of the sleep-Aβ relationship followed closely the Aβ accumulation pattern in 69 patients with mild cognitive impairment or AD. Thus, the results indicate that the relationship between sleep problems and Aβ accumulation may involve Homer1 activity in the cortical regions, where harbor Aβ deposits in AD. The findings may advance our understanding of the relationship between sleep problems and AD risk.

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