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1
Lailatul Fithriyah Azzakiyah, Lastaria. "HOMONIMI DAN AMBIGUITAS FONETIK DALAM MAHALABIU (HOMONYMY AND AMBIGUITY PHONETIC IN MAHALABIU." JURNAL BAHASA, SASTRA DAN PEMBELAJARANNYA 10, no. 2 (2020): 243. http://dx.doi.org/10.20527/jbsp.v10i2.9379.
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AbstractHomonymy and Ambiguity Phonetic in Mahalabiu. Homonymy is a form of wordsthat have different meanings but the pronunciation or spelling is the same andambiguity is the ability to express more than one interpretation. In this case, it isrelated to the ‘mahalabiu discourse’ which tends to have multiple meanings ineveryday language usage. The method used in this research is a descriptivequalitative method. Data collection techniques using interview techniques andrecording techniques. As for the object of research is the indigenous people of theBanjar tribe who live in the Alabio village. In ‘mahalabiu’, there are several formsof homonymy, namely: “maharakan, tarap, Langgar, Pagat, tinjak, maling, haur,dikalang, pusat, nyawa, dan kuitan”. In addition, there is also homonymy which ishomophony and homonymy which is homograph. (1) Homophony is the same soundbut different in writing and meaning, namely: “maharumi (maharu mi), kadada (kadada), dan anakutu (anakku tu)”;and (2) homography in ‘mahalabiu’ occurs as aresult of the unification of vocabulary in phonetic pronunciation, namely“bakicap”. Other than that,in ussing the word mahalabiu on average contains adouble meaning, this occurs due to the use of the word homonymy, while the contextin the conversation is not clear, resulting in inactivity.Key words: homonymy, phonetic ambiguity, mahalabiuAbstrakHomonimi dan Ambiguitas Fonetik dalam Bahasa Mahalabiu. Homonimi adalahbentuk kata yang memiliki makna yang berbeda tetapi pelafalan atau ejaannyasama dan ambiguitas adalah kemampuan mengekspresikan lebih dari satupenafsiran. Dalam hal ini berkaitan dengan mahalabiu yang cenderungmenimbulkan makna ganda dalam pemakaian bahasa sehari-hari. Metode yangdigunakan dalam penelitian ini ialah metode kualitatif yang bersifat deskriptif.Teknik pengumpulan data menggunakan teknik wawancara dan teknik rekaman.Adapun yang menjadi objek penelitian ialah masyarakat asli suku Banjar yangtinggal di desa Alabio. Dalam wacana mahalabiu terdapat beberapa bentukhomonimi, yaitu: “maharakan, tarap, langgar, Pagat, tinjak, maling, haur,dikalang, pusat, nyawa, dan kuitan”. Selain itu, ada pula homonimi yang bersifathomofoni dan homonimi yang bersifat homograf. (1) Homofoni merupakan bunyiyang sama tetapi berbeda tulisan dan maknanya, yaitu: “maharumi (maharu mi),kadada (ka dada), dan anakutu (anakku tu)”; dan (2) homografi dalam mahalabiuterjadi akibat dari penyatuan kosakata dalam pelafalan fonetik, yaitu “bakicap”.Selain itu, dalam pemakaian katamahalabiu rata-rata mengandung makna gandahal ini terjadi dikarenakan pemakaian kata homonimi, sedangkan konteks dalampercakapan tidak jelas sehingga muncul ketaksaan.Kata-kata kunci:homonimi, ambiguitas fonetik, mahalabiu
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Choudhary, Shiv Kumar, Sushant Srivastava, Horisk Chander, et al. "Early Experience with Homograft Valve Banking." Asian Cardiovascular and Thoracic Annals 5, no. 3 (1997): 137–40. http://dx.doi.org/10.1177/021849239700500303.
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Homograft cardiac valves have been shown to have several advantages over conventional prosthetic valves. From October 1993 through November 1996, 273 homografts (262 valved and 11 non-valved) were used in various procedures at the All India Institute of Medical Sciences, New Delhi, India. The recommendations of the American Association of Tissue Banks were followed for procurement, harvesting, and storage of the valves. One hundred and ninety-six hearts were procured yielding a total of 439 homograft valves; 192 were pulmonary homografts, 187 were aortic homografts, and 60 were mitral homografts. Eighty-five homografts were used in the Ross procedure, 64 were used in homograft replacement of the aortic valve, 28 were used in replacement of the mitral valve, 85 were used in various operations for heart disease as valved conduits, and 11 homografts were used as either non-valved conduits or for patch repair. One hundred and thirty-five homografts (31%) were discarded for various reasons. Our early experience of valve banking is discussed.
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Neng, Lee Chuen, Luo Hong He, Christie TT Tan, Eugene KW Sim, Zhang Ming Jie, and Adrian KY Ong. "Long-Distance Procured Homograft-valved Conduit Replacement for Congenital Heart Disease: Initial Experience with 10 Cases." Asian Cardiovascular and Thoracic Annals 3, no. 2 (1995): 42–45. http://dx.doi.org/10.1177/021849239500300202.
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We review our experience from January 1987 to September 1992 with the surgical treatment of complex congenital malformations requiring an extracardiac homograft-valved conduit. There were 10 patients in the series; 7 pulmonary and 3 aortic homografts were implanted. Ages ranged from 1 month to 26 years (mean 7.9). There were 4 cases of hospital mortality, none related to the homograft itself. The major postoperative complication was low cardiac output syndrome. The 6 survivors have been followed between 3 months and 5 years and no dysfunction of the valved homograft, thromboembolism, or hemolysis have been recorded. All the survivors are symptom-free with a good quality of life. The use of homografts is advised in selected cases of right and left ventricular tract reconstruction for congenital heart disease; homografts are easy to handle and offer several technical advantages over prosthetic tissues.
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Bisdas, Mattner, Ott, et al. "Significance of infection markers and microbiological findings during tissue processing of cryopreserved arterial homografts for the early postoperative course." Vasa 38, no. 4 (2009): 365–73. http://dx.doi.org/10.1024/0301-1526.38.4.365.
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Background: To evaluate homograft implantation for the urgent treatment of vascular infections on the basis of the course of infection using microbiological findings in perioperatively obtained specimens and during homograft processing. Patients and methods: 85 patients were treated with cryopreserved homografts from 2004-2007. The microbiological findings of the decontamination process of homografts in the tissue bank were evaluated. The perioperative infection profile (microorganisms, CRP, leukocytes, body temperature) of the patients was analysed. Results: Complete microbiological and clinical follow-up for the postoperative course was available for 35 patients, who were treated with homografts from the same tissue bank and finally included into this study. 55 cryopreserved homografts were implanted. 35 / 55 (64 %) homografts were positive for microorganisms before decontamination. 3 / 35 (9 %) homografts remained positive after the decontamination. 33 patients were operated for prosthetic graft infection and 2 for an infiltration of a large vessel from neighbouring malignant disease. The most common infection agent was Staphylococcus aureus. Thirty-day mortality was 20 % (7 / 35). Only in 4 / 35 (11 %) patients were the microorganisms of the intraoperative swabs also detected during the postoperative course. The microorganisms were ORSA, Enterococcus faecium, Enterobacter aerogenes and Burkholderia cepacia. The patient with ORSA infection died on POD 11 from multiple organ failure and all other patients recovered. None of the postoperative swabs showed the homograft predecontamination microorganisms. Interestingly, a significant association (P = 0.003) between C-reactive protein increase two weeks after surgery and donor-recipient ABO mismatch was found. Conclusions: The implantation of homografts following the established decontamination is an alternative urgent therapeutic option in vascular infections with encouraging outcomes. The absence of the predecontamination focus in the postoperative specimens of patients, suggests that the postoperative course and outcomes show no strong relation to potential homograft contamination prior to the decontamination process.
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Mestres, Carlos-A., Ramón Cartaña, Manuel Castella, Jaime Mulet, and José L. Pomar. "Ascending Aorta to Femoral Bypass with Cryopreserved Vascular Homografts." Asian Cardiovascular and Thoracic Annals 3, no. 2 (1995): 90–92. http://dx.doi.org/10.1177/021849239500300216.
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Homograft vascular replacement is almost as old as vascular surgery itself. Gross and Dubost are credited as the first authors who clinically attempted vascular reconstruction using biological tissue of human origin. The advent of synthetic vascular prostheses together with the complexity of logistics in procuring, preserving, and storing vascular homografts made the routine use of vascular homografts impractical. Cryopreservation techniques have strongly influenced the use of biological tissue. The tireless work of a few authors has enabled us to better understand the behavior of homograft tissues in cardiovascular surgery. Homograft replacement of the aortic and pulmonary valves is now a recognized way to treat a number of conditions of the aortic root and the right ventricular outflow tract. Renewed interest in the use of cryopreserved homografts in cardiac surgery has led us to expand our own indications for their use. As our Cryopreservation Unit is fully operative, we also have vascular homografts available for implantation. Here we describe the extended use of vascular homografts in extraanatomic aortic bifurcation bypass in a patient with previous multiple vascular operations. To use the ascending aorta as the inflow source in cardiovascular reconstruction has been previously described; however, it has not been popular among surgeons. Robicsek termed this type of bypass graft “very long” aortic grafts, and we recently had the chance to use fully biological tissue of human origin for this type of reconstruction.
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Bertels, Robin A., Michiel Dalinghaus, Maarten Witsenburg, et al. "Results of balloon dilatation of stenotic homografts in pulmonary position in children and young adults." Cardiology in the Young 22, no. 5 (2012): 589–95. http://dx.doi.org/10.1017/s1047951112000157.
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AbstractObjectivesTo evaluate the results of balloon dilatation of stenotic homografts in children, adolescents, and young adults and to identify factors that might influence or predict the effect of the dilatation.BackgroundHomografts are widely used in congenital cardiac surgery; however, the longevity remains a problem mostly because of stenosis in the homograft. The effect of treatment by balloon dilatation is unclear.MethodsIn a retrospective study, the effect of balloon dilatation was determined by the percentage of reduction of the peak systolic pressure gradient over the homograft during catheterisation and the postponement of re-intervention or replacement of the homograft in months. Successful dilatations – defined in this study as a reduction of more than 33% and postponement of more than 18 months – were compared with unsuccessful dilatations in search of factors influencing or predicting the results.ResultsThe mean reduction of the peak systolic pressure gradient was 30% in 40 procedures. Re-intervention or replacement of the homograft was postponed by a mean of 19 months. In all, 14 balloon dilatations (35%) were successful; the mean reduction was 49% and the mean postponement was 34 months. The time since homograft implantation, the presence of calcification, the homograft/balloon ratio, and the pressure applied during dilatation all tended to correlate with outcome, but were not statistically significant.ConclusionsBalloon dilatation is able to reduce the peak systolic pressure gradient over homografts in a subgroup of patients and can be of clinical significance to postpone re-intervention or pulmonary valve replacement.
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Axelsson, Ida, Torsten Malm, and Johan Nilsson. "Impact of valve fenestrations and structural changes in homografts on the long-term outcome in the recipient." Cell and Tissue Banking 22, no. 3 (2021): 399–408. http://dx.doi.org/10.1007/s10561-020-09886-5.
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AbstractHomografts have long been used for right ventricular outflow tract (RVOT) reconstruction. Tissue banks struggle to meet the clinical demand of tissue, with insufficient donor availability and strict recommendations on tissue quality with high proportions of discards. This study analyzes the long-term outcome of patients receiving a homograft with small fenestrations of the cusps or other structural changes, to evaluate if minor impairment of the homograft affects the durability. Homograft characteristics and patient outcome were described. Follow-up was maximum 24 years. Structural changes of the homografts were analyzed in relation to patient outcome, using univariable and multivariable Cox proportional hazard regression. Between 1995 and 2018, 468 patients received 535 homografts in the RVOT in Lund. Median recipient age was 13 years. There were 137 (26.9%) reinterventions. Freedom from reintervention was 75.8% (95% CI 71.3–79.7%) at 10 years and 57.4% (95% CI 50.0–64.0%) at 20 years. Small fenestrations of the cusps, fibrosis of the cusps and minor atheromatosis of the vessel did not show any statistically significant impact on long-term outcome, hazard ratio = 0.46 (95% CI 0.11–1.87, p = 0.276) and hazard ratio = 0.80 (95% CI 0.25–2.56, p = 0.704). Minor structural changes of the homografts seem to be acceptable without affecting the long-term durability.
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Schroeder, Meierling, Riepe, Braun, and Imig. "Behandlung einer aortobifemoralen Protheseninfektion durch Rekonstruktion mit kryokonservierten homologen Arterien aus der European Homograft Bank." Vasa 28, no. 1 (1999): 42–45. http://dx.doi.org/10.1024/0301-1526.28.1.42.
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The excision of an infected aortobifemoral Dacron graft 9 years after implantation and bilateral axillofemoral Dacron bypass reconstruction led to reinfection of the extra-anatomic bypass grafts. A new aorto-bifemoral reconstruction was performed using cryopreserved homografts delivered by the European Homograft Bank in Brussels and both axillo-femoral prostheses were removed. No signs of infection and no alterations of the homografts can be detected 3 years later.
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Yanagawa, Bobby, Amine Mazine, Derrick Y. Tam, et al. "Homograft versus Conventional Prosthesis for Surgical Management of Aortic Valve Infective Endocarditis." Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery 13, no. 3 (2018): 163–70. http://dx.doi.org/10.1097/imi.0000000000000510.
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Objective Surgical management of aortic valve infective endocarditis (IE) with cryopreserved homograft has been associated with lower risk of recurrent IE, but there is equipoise with regard to the optimal prosthesis. This systematic review and meta-analysis were performed to compare outcomes between homograft and conventional prosthesis for aortic valve IE. Methods We searched MEDLINE database to September 2017 for studies comparing homograft versus conventional prosthesis. The main outcomes were all-cause mortality, recurrent IE, and reoperation. Results There were 18 included comparative observational studies with 2232 patients (median follow up = 5 [interquartile range: 2–7] years, 30% prosthetic valve endocarditis); four studies were adjusted for baseline differences. There were no differences in perioperative mortality or stroke despite a greater proportion of staphylococcal endocarditis, abscess, and root replacements but less multivalve involvement in the homograft group. Long-term outcomes of all-cause mortality [incidence rate ratio (IRR) = 1.03, 95% confidence interval (CI) = 0.81–1.31, P = 0.83, for unmatched, and IRR = 0.82, 95% CI = 0.36–1.84, P = 0.63, for matched studies], recurrent endocarditis (IRR = 1.01, 95% CI = 0.53–1.93, P = 0.96, for unmatched, and IRR = 1.04, 95% CI = 0.49–2.19, P = 0.92, for matched studies), and reoperation (IRR = 1.60, 95% CI = 0.80–3.21, P = 0.18, for unmatched, and IRR = 3.17, 95% CI = 0.52–19.44, P = 0.21, for matched studies) were not different comparing homograft versus conventional prosthesis. There was a significantly increased need for reoperation with homograft versus mechanical prosthetic valves, but this comparison was based on limited data. Conclusions Homografts and conventional prostheses offer similar survival and freedom from recurrent endocarditis and reoperation for aortic valve IE. Homografts may be associated with greater risk of reoperation compared with mechanical valves.
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McGee, Michael, J. V. D. Hough, and Mark W. Wood. "Homograft Microlathed Femur Prosthesis in Stapedectomy." Ear, Nose & Throat Journal 81, no. 3 (2002): 169–71. http://dx.doi.org/10.1177/014556130208100312.
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The use of homografts in ossiculoplasty has been well documented in the literature. In the early 1980s, nonossicular homograft otic capsule bone was used as a prosthetic material in stapedectomy. We began using homograft femur as a prosthetic material in the early 1990s. In this article, we report the results of a retrospective study of the use of homograft femur prostheses. A series of 300 stapedectomies was performed between Aug. 24, 1992, and Jan. 20, 2000. Total footplate removal with preservation of the posterior crus was our procedure of choice. However, in 116 of these cases, the posterior crus could not be used, and a homograft femur prosthesis was substituted. For these prostheses, all homograft femurs were obtained from the American Red Cross. All prostheses were prepared in the bone laboratory and stored in the bone bank until needed. After an adequate period of follow-up, we tabulated our results. We found that in 89 of 113 cases (78.8%) available for follow-up, the air-bone gap was completely closed. In addition, the air-bone gap was closed to within 5 dB in 11 patients (9.7%) and closed to within 10 dB in five patients (4.4%). In all, 105 of the 113 homograft femur prosthetic procedures (92.9%) resulted in a successful outcome.
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Glasgold, Alvin I., Mark J. Glasgold, and Frederick H. Silver. "Cartilage Grafts in Nasal Surgery." American Journal of Rhinology 3, no. 3 (1989): 167–71. http://dx.doi.org/10.2500/105065889782009660.
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Cartilage grafts are being used with increasing frequency in nasal surgery, particularly with the growing popularity of open rhinoplasty. The properties of cartilage that make it a preferred grafting material are discussed as well as the historical data relating to the survival of cartilage autografts and homografts. The preferred source of cartilage grafts has been the patient's septum. This is not always feasible because of prior surgical removal or inadequate strength or size. The purpose of this paper is to describe the types of cartilage grafts commonly available for use in nasal surgery. The advantages and limitations of each are discussed. Four clinical cases are presented, demonstrating the use of septal cartilage autograft, septal homograft, irradiated rib cartilage homograft, and conchal cartilage autograft.
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Falchetti, Alessandro, Hélène Demanet, Hugues Dessy, Christian Melot, Charalampos Pierrakos, and Pierre Wauthy. "Contegra versus pulmonary homograft for right ventricular outflow tract reconstruction in newborns." Cardiology in the Young 29, no. 4 (2019): 505–10. http://dx.doi.org/10.1017/s1047951119000143.
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AbstractObjectives:Pulmonary homografts are standard alternatives to right ventricular outflow tract reconstruction in congenital heart surgery. Unfortunately, shortage and conduit failure by early calcifications and shrinking are observed for small-sized homografts in younger patients. In neonates, Contegra® 12 mm (Medtronic Inc., Minneapolis, Minnesota, United States of America) could be a valuable alternative, but conflicting evidence exists. There is no published study considering only newborns with heterogeneous pathologies. We retrospectively compared the outcomes of these two conduits in this challenging population.Methods:Patients who underwent a right ventricular outflow tract reconstruction between January 1992 and December 2014 at the Hôpital Universitaire des Enfants Reine Fabiola were included. We retrospectively collected and analysed demographic, echocardiographic, surgical, and follow-up data.Results:Of the 53 newborns who benefited from a right ventricular outflow tract reconstruction during the considered period, 30 received a Contegra 12 mm (mean age 15 ± 8 days), and 23 a small (9–14 mm) pulmonary homograft (mean age 10 ± 7 days). Overall mortality was 16.6% with Contegra versus 17.4% in the pulmonary homograft group (p = 0.98 log-rank). Operative morbidity and early re-operation for conduit failure were not significantly different between the two groups. Mean follow-up in this study is 121 ± 74 months. Survival free from re-operation was not different between the two groups (p = 0.15). Multivariable analysis showed that weight and significant early gradient were factors associated with anticipated conduit failure.Conclusions:Contegra 12 mm is a valid alternative to small pulmonary homografts in a newborn patient population. Trial registration: NCT03348397.
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Mahmoud El-Meanawy, Amr, Tarek Fouad Keshk, Magdy Ahmed Lolouah, and Medhat Samy Hassan. "The reliability of use of combined homograft and autograft in management of major burns." International Surgery Journal 6, no. 5 (2019): 1436. http://dx.doi.org/10.18203/2349-2902.isj20191559.
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Background: The aim of the study to present the reliability of application of intermingled skin homoograft and autograft in major deep burn cases in comparison with using homograft only. Early excision and skin graft closure of major burns is a life-saving procedure that reduces morbidity and mortality of severe burns. Patients suffering major burns lack adequate donor site skin graft to resurface burn wounds so they need another substitutes for coverage as homograft.Methods: This cohort prospective study was conducted at Menoufia University Hospitals from January 2017 to January 2019 and with follow up 6 months. The population of the study was 54 patients with major deep burns. After stabilization they were divided into 2 groups, the first underwent homograft and the second underwent combined homograft and autograft. They vary between children and adults. Follow up done over 6 months regarding rejection, need of another graft and mortalityResults: Our study was undergone on 54 patients; 30 patients homograft (55.5%) and 24 patients combined grafts (44.5%). Forty eight patients survived, and six patients died (12.5%), with a mean age 26.3 years (range, 1-50). There was statistically significant difference between 2 groups regarding rejection time, need of another graft, percentage of rejected area and mortality.Conclusions: Combined homografts and autografts is considered gold standard in management of major burns with lack of adequate autograft. It is superior to use of homograft only regarding morbidity, mortality and need for another graft.
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Attanawanich, Sukasom, Pongsak Khowsathit, and Wichaya Withurawanit. "Correction of Absent Pulmonary Valve Syndrome Using a Pericardial Valved Conduit." Asian Cardiovascular and Thoracic Annals 10, no. 3 (2002): 270–72. http://dx.doi.org/10.1177/021849230201000321.
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Absent pulmonary valve syndrome in a 4-month-old infant was successfully corrected using a fresh autologous pericardial trileaflet valved conduit. He recovered from operation with only mild pulmonary regurgitation at 4 months postoperatively. This technique is an effective alternative for infants with congenital heart disease who need tissue valved conduits. It may be more suitable than the aortic homograft by reason of the shortage of small homografts and its lower costs.
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Nurhayati, I. Nyoman Sudika, and Ratna Yulida Ashriany. "Homografi dalam Bahasa Sasak di Kelurahan Tanjung Kabupaten Lombok Timur." Jurnal Bastrindo 1, no. 1 (2020): 67–86. http://dx.doi.org/10.29303/jb.v1i1.11.
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Abstrak: Permasalahan dalam penelitian ini, yaitu (1) Bagaimanakah wujud homografi dalam bahasa Sasak di Kelurahan Tanjung Kabupaten Lombok Timur? (2) Bagaimanakah distribusi homografi dalam pembentukan kalimat ? (3) Bagaimanakah makna leksem homografi ? Tujuan penelitian ini adalah untuk (1) mengidentifikasi wujud homografi dalam bahasa Sasak di Kelurahan Tanjung Kabupaten Lombok Timur, (2) mengidentifikasi distribusi homografi dalam pembentukan kalimat, (3) mendeskripsikan makna leksem homografi. Dalam pengumpulan data digunakan beberapa metode, yaitu: 1) metode introspeksi, 2) metode cakap, dan 3) metode simak. Metode analisis data yang digunakan adalah metode padan intralingual dan metode padan ekstralingual. Hasil penelitian ini adalah (1) wujud leksem berhomografi walaupun memiliki wujud yang sama tetapi lafal dan maknanya berbeda, sehingga dikategorikan sebagai homografi. Contohnya, leksem lekaq [lEka?] yang bermakna ‘jalan’ dan leksem lekaq [l?ka?] yang bermakna ‘lepas’, (2) distribusi leksem homografi dalam pembentukan kalimat yaitu secara umum leksem homografi dapat menempati posisi di awal kalimat, di tengah kalimat, dan di akhir kalimat. Namun, ada beberapa leksem homografi yang tidak berdistribusi lengkap, (3) makna masing-masing leksem homografi berbeda-beda dan mengacu pada makna leksikalnya. Akan tetapi, berdasarkan distribusi leksem homografi dalam kalimat, makna leksem tersebut tidak selalu sama dengan makna leksikalnya. Selain itu, makna leksem homografi ini mengalami perubahan saat berada di dalam konteks kalimat yang berbeda. Abstract: The problems in this study, namely (1) How is the form of homography in Sasak in Tanjung subdistrict, East Lombok Regency ? (2) What is the distribution of homography in sentence formation ? (3) What is the meaning of homographic lexeme ? The purpose of this study was to (1) identify homogeneous forms in Sasak in Tanjung Subdistrict, East Lombok Regency, (2) identify homographic distributions in sentence formation, (3) describe the meaning of homographic lexemes. In collecting data, several methods are used, namely: 1) the introspection method, 2) the competent method, and 3) the listening method. Data analysis methods used are the intralingual equivalent method and the extralingual equivalent method. The results of this study are (1) the shape of the lexeme having a homograph even though it has the same form but the pronunciation and meaning are different, so they are categorized as homography. For example, leksem lekaq [lEka?] which means 'path' and leksem lekaq [l?ka?] Which means 'loose', (2) the distribution of homographic lexemes in sentence formation that is generally homographic lexemes can occupy positions at the beginning of a sentence, in the middle of a sentence , and at the end of the sentence. However, there are some homographical lexemes that are not fully distributed, (3) the meanings of each homographic lexeme are different and refer to the lexical meaning. However, based on the distribution of homographic lexemes in sentences, the meaning of the lexeme is not always the same as the lexical meaning. In addition, the meaning of this homographic lexeme changes when it is in the context of different sentences.
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Metin, SK, BS Uğurlu, Ö. Oto, et al. "Fresh Homografts Obtained through a National Organ-Sharing Programme for Repair of Congenital Heart Disease." Journal of International Medical Research 33, no. 1 (2005): 123–33. http://dx.doi.org/10.1177/147323000503300114.
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Homografts have been used in congenital cardiac surgery for over 30 years. We utilized the resources of a national organsharing programme to obtain fresh homografts and report their use in correcting cardiac pathologies in 20 children between March 2001 and May 2003. In 16 patients, a valved conduit was used to form a connection between the pulmonary ventricle and the pulmonary artery. In three patients, a non-valved aortic conduit was used to form an extracardiac Fontan circulation and in one patient, non-valved pulmonary and aortic conduits were used to repair an infected aortic aneurysm. Three patients died following surgery. Survivors were followed up using echocardiography between 2 and 24 months post-surgery. Results demonstrate that, with the help of a national organ-sharing programme, the use of fresh homograft conduits is feasible in a paediatric patient population with reasonable waiting times.
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Marathe, Supreet P., Douglas Bell, Kim Betts, et al. "Homografts versus stentless bioprosthetic valves in the pulmonary position: a multicentre propensity-matched comparison in patients younger than 20 years†." European Journal of Cardio-Thoracic Surgery 56, no. 2 (2019): 377–84. http://dx.doi.org/10.1093/ejcts/ezz021.
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Abstract OBJECTIVES The aim of this study was to compare the performance of pulmonary homografts with stentless bioprosthetic valves [Medtronic Freestyle™ (Medtronic, Minneapolis, MN, USA)] in the pulmonary position in patients with congenital heart disease (CHD) younger than 20 years. METHODS Between January 2000 and December 2017, 215 patients were retrospectively identified from hospital databases in 3 congenital heart centres in Australia. Valve performance was evaluated using standard criteria. Propensity score matching was used to balance the 2 treatment groups. RESULTS Freedom from reintervention for patients who received a pulmonary homograft (n = 163) was 96%, 88% and 81% at 5, 10 and 15 years and for patients who received a Freestyle™ valve (n = 52) was 98%, 89% and 31% at 5, 10 and 15 years, respectively. Freedom from structural valve degeneration for patients with a homograft was 92%, 87% and 77% at 5, 10 and 15 years and for patients with a Freestyle valve was 96%, 80% and 14% at 5, 10 and 15 years, respectively. In the first 10 years, there was no difference in outcomes [reintervention hazard ratios (HR) = 0.69, 95% confidence intervals (CI) (0.20–2.42), P = 0.56; structural valve degeneration HR = 0.92 (0.34–2.51), P = 0.87]. After 10 years, the recipients of the Freestyle valves were at higher risk of both outcomes [reintervention HR = 7.89; 95% CI (2.79–22.34), P < 0.001; structural valve degeneration HR = 7.41 (2.77–19.84), P < 0.001]. The findings were similar when analysed by implantation in the orthotopic position and in the propensity-matched groups. CONCLUSIONS The Freestyle stentless bioprosthetic valve is a comparable alternative to cryopreserved pulmonary homografts up to 10 years after implantation when implanted in an orthotopic pulmonary position in patients younger than 20 years with CHD.
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Vogt, Ferdinand, Anke Kowert, Andres Beiras-Fernandez, et al. "Pulmonary Homografts for Aortic Valve Replacement: Long-term Comparison with Aortic Grafts." Heart Surgery Forum 14, no. 4 (2011): 237. http://dx.doi.org/10.1532/hsf98.20101162.
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<p><b>Objective:</b> The use of homografts for aortic valve replacement (AVR) is an alternative to mechanical or biological valve prostheses, especially in younger patients. This retrospective comparative study evaluated our single-center long-term results, with a focus on the different origins of the homografts.</p><p><b>Methods:</b> Since 1992, 366 adult patients have undergone AVR with homografts at our center. We compared 320 homografts of aortic origin and 46 homografts of pulmonary origin. The grafts were implanted via either a subcoronary technique or the root replacement technique. We performed a multivariate analysis to identify independent factors that influence survival. Freedom from reintervention and survival rates were calculated as cumulative events according to the Kaplan-Meier method, and differences were tested with the log-rank test.</p><p><b>Results:</b> Overall mortality within 1 year was 6.5% (21/320) in the aortic graft group and 17.4% (8/46) in the pulmonary graft group. In the pulmonary graft group, 4 patients died from valve-related complications, 1 patient died after additional heterotopic heart transplantation, and 1 patient who entered with a primary higher risk died from a prosthesis infection. Two patients died from non-valve-related causes. During the long-term follow-up, the 15-year survival rate was 79.9% for patients in the aortic graft group and 68.7% for patients in the pulmonary graft group (<i>P</i> = .049). The rate of freedom from reoperation was 77.7% in the aortic graft group and 57.4% in the pulmonary graft group (<i>P</i> < .001). The reasons for homograft explantation were graft infections (aortic graft group, 5.0%; pulmonary graft group, 6.5%) and degeneration (aortic graft group, 7.5%; pulmonary graft group, 32.6%).</p><p><b>Conclusion:</b> Our study demonstrated superior rates of survival and freedom from reintervention after AVR with aortic homografts. Implantation with a pulmonary graft was associated with a higher risk of redo surgery, owing to earlier degenerative alterations.</p>
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Barili, Fabio, Luca Dainese, Anna Guarino, Paolo Biglioli, and Gianluca Polvani. "The Challenge of Homograft Tissue Banks: The Viability of Cryopreserved Valvular Homografts." Journal of Heart and Lung Transplantation 26, no. 9 (2007): 964–65. http://dx.doi.org/10.1016/j.healun.2007.07.005.
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Claus, Benjamin, Nadine Woythal, Simon Dushe, Volkmar Falk, Herko Grubitzsch, and Torsten Christ. "The Ross Procedure in Adults: Long-Term Results of Homografts and Stentless Xenografts for Pulmonary Valve Replacement." Thoracic and Cardiovascular Surgeon 65, no. 08 (2016): 656–61. http://dx.doi.org/10.1055/s-0036-1586157.
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Background The Ross procedure is an established method to treat aortic valve disease, offering excellent hemodynamic characteristics, growth potential, low risk of thromboembolism and no need for anticoagulation. Limitation of homograft quality and availability led to the use of different stentless xenografts. Long-term outcome and implications are yet to be addressed. Methods Forty five adult patients (mean age 38.8 ± 9.6 years) with aortic valve stenosis and/or insufficiency, who underwent the Ross procedure between 1995 and 2002 were identified for long-term evaluation. Patients younger than 18 years, with previous heart surgery and endocarditis were excluded. Stentless xenografts were used in 22 cases (Group X) and homografts in 23 cases (Group H). After review of the patients' history, morbidity and mortality were analyzed and risk stratification was performed. Results Between groups, baseline characteristics and operative data did not differ significantly. Total follow-up was 621.0 patient-years and 98.8% complete. Overall freedom from reoperation at 15 years was 68.4 ± 10.6% in group X and 85. ± 7.9% in group H (p = 0.09), respectively. Freedom from aortic valve reoperation at 15 years was comparable (83.9 ± 8.5% in group X and 85.3 ± 7.9% in group H, p = 0.61), whereas freedom from pulmonary valve reoperation at 15 years was significantly lower in group X (78.9 ± 9.4% versus 100%, p = 0.02). Long-term survival at 15 years was 79.7 ± 9.3% in group X and 94.4 ± 5.4% in group H (p = 0.07), respectively. Conclusions Stentless xenografts used as pulmonary valve substitute in the Ross procedure led to lower freedom from pulmonary valve reoperation compared with homografts. Additionally, there was a trend to inferior long-term survival with xenografts. Therefore, homografts should remain the preferred option for pulmonary valve replacement in the Ross procedure.
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Nasirov, Teimour, Katsuhide Maeda, and Olaf Reinhartz. "Aortic or Pulmonary Valved Homograft Right Ventricle to Pulmonary Artery Conduit in the Norwood Procedure." World Journal for Pediatric and Congenital Heart Surgery 10, no. 4 (2019): 499–501. http://dx.doi.org/10.1177/2150135119842865.
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Background: Several modifications of the Norwood procedure utilizing valved right ventricle to pulmonary artery conduits have recently been reported. Our group has been using aortic or pulmonary valved homografts combined with PTFE tube grafts for now 16 years. Methods: In this report, we review our technique in detail and describe any changes that have occurred over the years. We provide detailed illustrations of our preferred surgical technique, report outcome data, and compare it to the other conduit options available. Results: Between 2006 and 2015, 130 stage I Norwood procedures were performed at our institution, 100 of them using valved conduits. Our technique is described and illustrated in detail. Early mortality was 15%. Postoperative percutaneous intervention on the conduit was required in 29% of cases. Conclusions: While a randomized trial comparing different valved conduits is lacking, we believe a composite conduit made from homograft aortic or pulmonary valves and PTFE tube grafts is an excellent choice in stage I Norwood procedure.
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Saxena, Akshat, Gananjay G. Salve, Kim Betts, et al. "Outcomes Following Heterotopic Placement of Right Ventricle to Pulmonary Artery Conduits." World Journal for Pediatric and Congenital Heart Surgery 12, no. 2 (2021): 220–29. http://dx.doi.org/10.1177/2150135120975769.
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Background: We sought to evaluate the outcomes following right ventricle to pulmonary artery (RV-PA) conduit placement in pediatric patients, excluding those with a RV-PA conduit for the Ross procedure which is associated with improved conduit durability, partly related to its orthotopic position. Methods: Outcomes for 119 patients who underwent RV-PA conduit placement at a single institution from January 2004 to December 2016 were reviewed. Primary outcome measures were reintervention-free survival (RFS) and overall survival. Survival analyses were performed using the Kaplan-Meier method, and risk factors associated with reintervention were evaluated. Results: The median age at the time of conduit placement was 6 months (interquartile range, IQR: 1-14), and the median length of follow-up was 63 months (range: 0-156). During follow-up, 39 patients required conduit-related reintervention, while 6 patients died perioperatively with an overall survival of 90% at 10 years. Among the remaining 113 patients, the RFS at one, five, and ten years was 91% (84%-95%), 72% (60%-80%), and 33% (16%-50%), respectively. The median time to conduit replacement in the series was 43.5 months (IQR: 19.3-76.2). The use of a pulmonary homograft was associated with improved RFS ( P = .03), and this was particularly pronounced in comparison with aortic homografts in neonates. Infection was the indication for replacement in only one patient. Conclusions: The majority of the conduits placed during the neonatal period required conduit replacement before the age of five years. Endocarditis was not a common indication for replacement. In neonates and infants, we prefer pulmonary homografts for most indications.
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Čanádyová, Júlia, and Aleš Mokráček. "Calcified aortic homograft and sutureless valves." Cor et Vasa 57, no. 5 (2015): e362-e365. http://dx.doi.org/10.1016/j.crvasa.2015.02.001.
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Ramírez-Marroquín, Samuel, Pedro José Curi-Curi, Juan Calderón-Colmenero, José Antonio García-Montes, and Jorge Luis Cervantes-Salazar. "Common Arterial Trunk Repair by Means of a Handmade Bovine Pericardial-Valved Woven Dacron Conduit." World Journal for Pediatric and Congenital Heart Surgery 8, no. 1 (2016): 69–76. http://dx.doi.org/10.1177/2150135116674439.
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Background: Surgical repair of common arterial trunk (CAT) by means of a homograft conduit has become a standard practice. We report our experience in the correction of this heart disease with a handmade bovine pericardial-valved woven Dacron conduit as an alternative procedure to homografts, with a focus on early, mid-term, and long-term results. Methods: We designed a retrospective study that included 15 patients with a mean age of 1.5 years (range: three months to eight years), who underwent primary repair of simple CAT. Right ventricular outflow tract was reconstructed in all the cases with this handmade graft that was explanted at the time of its biological stenotic degeneration. A peeling procedure was performed at this time, in order to reconstruct the right ventricle-to-pulmonary artery continuity. Results: Overall mortality was 13.3% (one death at the early postoperative primary repair and the other at the mid-term postoperative peeling reoperation). Actuarial survival rate was 93.3%, 86.7%, and 86.7% at 5, 10, and 15 years, respectively. All of the 14 survivors developed stenosis of the handmade conduit at the mid-term period (8 ± 3 years), but after the peeling procedure, 13 survivors remain asymptomatic to date. Conclusions: Primary repair of common arterial trunk using a handmade conduit can be performed with very low perioperative mortality and satisfactory mid-term and long-term results, which can be favorably compared with those reported with the use of homografts. When graft obstruction develops, peeling procedure is a good option because it does not affect the overall survival, although long-term outcomes warrant further follow-up.
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Meyns, Bart, Ramadan Jashari, Marc Gewillig, et al. "Factors influencing the survival of cryopreserved homografts. The second homograft performs as well as the first☆." European Journal of Cardio-Thoracic Surgery 28, no. 2 (2005): 211–16. http://dx.doi.org/10.1016/j.ejcts.2005.03.041.
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Vendramin, Igor, Andrea Lechiancole, Daniela Piani, et al. "Use of Sutureless and Rapid Deployment Prostheses in Challenging Reoperations." Journal of Cardiovascular Development and Disease 8, no. 7 (2021): 74. http://dx.doi.org/10.3390/jcdd8070074.
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Sutureless and rapid-deployment bioprostheses have been introduced as alternatives to traditional prosthetic valves to reduce cardiopulmonary and aortic cross-clamp times during aortic valve replacement. These devices have also been employed in extremely demanding surgical settings, as underlined in the present review. Searches on the PubMed and Medline databases aimed to identify, from the English-language literature, the reported cases where both sutureless and rapid-deployment prostheses were employed in challenging surgical situations, usually complex reoperations sometimes even performed as bailout procedures. We have identified 25 patients for whom a sutureless or rapid-deployment prosthesis was used in complex redo procedures: 17 patients with a failing stentless bioprosthesis, 6 patients with a failing homograft, and 2 patients with the failure of a valve-sparing procedure. All patients survived reoperation and were reported to be alive 3 months to 4 years postoperatively. Sutureless and rapid-deployment bioprostheses have proved effective in replacing degenerated stentless bioprostheses and homografts in challenging redo procedures. In these settings, they should be considered as a valid alternative not only to traditional prostheses but also in selected cases to transcatheter valve-in-valve solutions.
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Salleh, Siti Farida, Yazid Yahya, Mary Fatimah Subet, and Muhammad Zaid Daud. "ANALISIS SEMANTIK LEKSIKAL DALAM NOVEL SANGKAR KARYA SAMSIAH MOHD. NOR." Asian People Journal (APJ) 3, no. 1 (2020): 45–63. http://dx.doi.org/10.37231/apj.2020.3.1.144.
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Abstract: Novel is one of the mediums of non-verbal communication that the author wishes to convey to the reader. Through the reading of this novel, the reader can experience a wide range of emotions. Whether it's sad, happy, excited and so on. Therefore, this study will explore the meaning behind the novel entitled "Sangkar" by Samsiah Mohd. Nor. The novel was published in 2010 through the publication of Alaf 21 Sdn. Bhd. There are 248 pages and 26 chapters for this novel. This study is a qualitative study consisting of annotated text analysis as well as a simple quantitative approach to finding lexical frequency and complexity in this Sangkar novel. To analyze this novel the researcher will apply a lexical semantic approach. Through this lexical semantic approach it is possible to classify lexical types into synonyms, antonyms, hyponyms, polysemic, homonyms, homophones, homographs, metonyms and meronyms. Based on the findings of this study, the frequency and percentage of total lexical semantics recorded a frequency value of 1019 (100%) lexical only. However, through the novel there was only partial lexical semantics comprising; antonyms–442 (43.37%), synonyms–218 (21.39%), meronyms–185 (18.15%) and hyponyms–174 (17.07%). It can be concluded that through this lexical semantic approach it is possible to classify different lexical groups into the same group of meanings.
 Keywords: Lexical semantics, meaning, novel, general reading
 
 Abstrak: Novel merupakan salah satu medium komunikasi bukan lisan yang ingin disampaikan oleh penulis kepada pembaca. Melalui pembacaan novel, pembaca dapat merasai emosi yang pelbagai. Sama ada sedih, gembira, teruja dan sebagainya. Oleh itu, kajian ini akan meneroka makna di sebalik novel yang bertajuk “Sangkar” oleh Samsiah Mohd. Nor. Novel ini diterbitkan pada tahun 2010 melalui penerbitan Alaf 21 Sdn. Bhd. Terdapat 248 muka surat dan 26 bab bagi novel ini. Kajian ini adalah berbentuk kualitatif iaitu analisis teks yang telah dibukukan serta pendekatan kuantitatif mudah untuk mendapatkan kekerapan dan peratusan leksikal dalam novel Sangkar ini. Bagi menganalisis novel ini pengkaji, akan mengaplikasikan pendekatan semantik leksikal. Melalui pendekatan semantik leksikal ini, pengkaji dapat mengelaskan jenis leksikal kepada sinonim, antonim, hiponim, polisim, homonim, homofon, homograf, metonim dan meronim. Melalui dapatan kajian ini, jumlah kekerapan dan peratusan bagi keseluruhan semantik leksikal ini mencatat nilai kekerapan sebanyak 1019 (100%) leksikal sahaja. Namun begitu, melalui novel ini, hanya terdapat pecahan semantik leksikal yang terdiri daripada antonim–442 (43.37%), sinonim–218 (21.39%), meronim–185 (18.15%) dan hiponim–174 (17.07%). Dapat dirumuskan bahawa, melalui pendekatan semantik leksikal ini, membolehkan pelbagai golongan leksikal yang berbeza dikelaskan dalam golongan makna yang sama.
 Kata kunci: Semantik leksikal, makna, novel, bacaan umum
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Hartyánszky, István, Barna Babik, Krisztina Kádár, Attila Tóth, László Göbölös, and Gábor Bogáts. "Több-billentyűs redoműtét felnőtt betegen komplex pulmonalis atresiában." Orvosi Hetilap 158, no. 14 (2017): 546–49. http://dx.doi.org/10.1556/650.2017.30710.
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Abstract: 30-year-old adult with complex pulmonary atresia (previous surgical procedures: in infancy: exploration, at age of 10: ventricular septal defect closing, unifocalization, homograft implantation between right ventricular outflow tract and pulmonary artery) has biventricular dysfunction because of aortic valve regurgitation, ascending aortic aneurysm, and homograft insufficienty. Multivalve surgery: aortic valve plasty, pulmonary homograft changes for homograft and ascending aortic reconstruction by graft were carried out successfully. In Hungary this was the first case of this type of surgery. Management of special problems (follow-up, correct diagnostics (echocardiography, MR, CT), indication and necessity of reoperation, optimal age) in adult patients with complex congenital heart defects produces excellent early and late surgical results. Orv. Hetil., 2017, 158(14), 546–549.
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Karaskov, A. M., I. I. Demin, R. M. Sharifulin, et al. "Different conduits for the right ventricular outflow tract reconstruction in adults during the Ross procedure." Patologiya krovoobrashcheniya i kardiokhirurgiya 17, no. 2 (2015): 23. http://dx.doi.org/10.21688/1681-3472-2013-2-23-27.
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We compared different conduits for the right ventricular outflow tract reconstruction (RVOT) in adults during the Ross procedure. Between 1998 and 2012, 586 consecutive adult patients underwent the Ross procedures. Mean age was 45,514,2 years. The RVOT was reconstructed with a diepoxy-treated xenografts in 372 and with glutaraldehyde-treated in 88 patients. A pulmonary homograft was used in 125 patients. Hospital mortality was 4,9%. Mean follow up was 43,216,9 months. At discharge systolic gradient was 8,1 3,7 mm.Hg for the pulmonary homograft, 11,44,7 mm.Hg for the diepoxytreated and 14,96,1 mm.Hg for the glutaraldehyde-treated xenopericardial conduits. Twenty eight patients underwent reoperation. The 3-year actuarial freedom from conduit explantation for pulmonary homograft was 100%, for diepoxy- and glutaraldehyde-treated xenopericardial conduits 99,20,7% and 84,74,7% respectively. Multivariable analysis identified the type of xenograft and age as independent factors for xenograft dysfunction. Results from this study show that the pulmonary homograft is the most preferred conduit for the RVOT reconstruction during the Ross procedure. The diepoxy-treated xenopericardial conduits are acceptable alternative to the homograft in patients older 45 years.
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Lubbe, D., and J. J. Fagan. "Revisiting the risks involved in using homograft ossicles in otological surgery." Journal of Laryngology & Otology 122, no. 2 (2007): 111–15. http://dx.doi.org/10.1017/s0022215107000795.
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AbstractDespite the fact that cartilage, cortical bone and corneal homograft tissue is still widely used in South Africa and that there has never been a reported case of human immunodeficiency virus or Creutzfeldt–Jakob disease infection transmission via this route, otolaryngologists are still reluctant to use homograft ossicles. In third world countries, such as South Africa, where ossicular prostheses are not always readily available due to financial constraints, the question arises as to whether we should be reconsidering the use of homograft ossicles. This review examines the risk of developing Creutzfeldt–Jakob disease or acquiring human immunodeficiency virus following the use of homograft ossicles during ossicular reconstruction, and discusses sterilization techniques that have proven effective in eradicating the human immunodeficiency virus and prions.For decades, homograft ossicles have been used worldwide in otological surgery, especially in patients lacking suitable autograft ossicles. There has never been a reported case of transmission of the human immunodeficiency virus, and no cases of transmissible spongiform encephalopathy have been reported in the literature after otological surgery involving only the use of homograft ossicles. There have only been two documented otological cases of Creutzfeldt–Jakob disease; these involved the use of cadaveric dura mater and pericardium for tympanic membrane grafting. The human immunodeficiency virus is easily inactivated by simple sterilisation techniques, and there is a statistically insignificant risk of transmitting this virus if proper sterilisation protocols are followed.
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Bia, Daniel, Edmundo I. Cabrera-Fischer, Yanina Zócalo, et al. "Vascular Accesses for Haemodialysis in the Upper Arm Cause Greater Reduction in the Carotid-Brachial Stiffness than Those in the Forearm: Study of Gender Differences." International Journal of Nephrology 2012 (2012): 1–10. http://dx.doi.org/10.1155/2012/598512.
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Purpose. To evaluate in chronically haemodialysed patients (CHPs), if: (1) the vascular access (VA) position (upper arm or forearm) is associated with differential changes in upper limb arterial stiffness; (2) differences in arterial stiffness exist between genders associated with the VA; (3) the vascular substitute (VS) of choice, in biomechanical terms, depends on the previous VA location and CHP gender.Methods. 38 CHPs (18 males; VA in upper arm: 18) were studied. Left and right carotid-brachial pulse wave velocity (PWVc-b) was measured. Inin vitrostudies, PWV was obtained in ePTFE prostheses and in several arterial and venous homografts obtained from donors. The biomechanical mismatch (BM) between CHP native vessel (NV) and VS was calculated.Results/Conclusions.PWVc-bin upper limbs with VA was lower than in the intact contralateral limbs (P<0.05), and differences were higher (P<0.05) when the VA was performed in the upper arm. Differences betweenPWVc-bin upper limbs with VA (in the upper arm) with respect to intact upper limbs were higher (P<0.05) in males. Independently of the region in which the VA was performed, the homograft that ensured the minimal BM was the brachial artery. The BM was highly dependent on gender and the location in the upper limb in which the VA was performed.
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Graf, Debra, and Lorenzo Gonzalez-Lavin. "The Homograft." AORN Journal 48, no. 5 (1988): 911–17. http://dx.doi.org/10.1016/s0001-2092(07)68281-7.
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Choudhary, Shiv Kumar, Anita Saxena, Bharat Dubey, and A. Sampath Kumar. "Pulmonary homograft." Journal of Thoracic and Cardiovascular Surgery 120, no. 1 (2000): 148–55. http://dx.doi.org/10.1067/mtc.2000.106653.
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Briceno-Medina, Mario, T. K. Susheel Kumar, Shyam Sathanandam, et al. "Femoral vein homograft as Sano shunt results in improved pulmonary artery growth after Norwood operation." Cardiology in the Young 28, no. 1 (2017): 118–25. http://dx.doi.org/10.1017/s1047951117001688.
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AbstractObjectiveTo evaluate differences in interstage growth of pulmonary arteries between use of polytetrafluoroethylene and femoral vein homograft as Sano shunt during stage-I Norwood palliation.MethodsA retrospective review of all patients who survived to the second stage following Norwood–Sano operation at two institutions was performed. Either polytetrafluoroethylene or the valved segment of femoral vein homograft was used for construction of the Sano shunt. The size of pulmonary arteries was compared at pre-Glenn catheterisation.ResultsA total of 48 neonates with the diagnosis of hypoplastic left heart syndrome or its variants comprised the study population. Femoral vein homograft of 5–6 mm diameter was used in 14 and polytetrafluoroethylene graft of 5 mm was used in 34 patients. The two groups were comparable in terms of preoperative demographics and age at time of pre-Glenn catheterisation (3.9±0.7 versus 3.4±0.8 months, p=0.06). Patients who received femoral vein homograft demonstrated a significantly higher pre-Glenn Nakata index [264 (130–460) versus 165 (108–234) mm2/m2, p=0.004]. The individual branch pulmonary arteries were significantly larger in the femoral vein group (right, 7.8±3.6 versus 5.0±1.2, p=0.014; left, 7.2±2.1 versus 5.6±1.9, p=0.02). There were no differences in cardiac index, Qp:Qs, ventricular end-diastolic pressure or systemic oxygen saturations.ConclusionsUtilisation of a valved segment of femoral vein homograft as right ventricle to pulmonary artery conduit during Norwood–Sano operation confers better interstage growth of the pulmonary arteries. Further studies are needed to evaluate the impact of femoral vein homograft on single ventricle function.
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Patel, Parth M., Jeremy L. Herrmann, Mark D. Rodefeld, Mark W. Turrentine, and John W. Brown. "Bovine jugular vein conduit versus pulmonary homograft in the Ross operation." Cardiology in the Young 30, no. 3 (2019): 323–27. http://dx.doi.org/10.1017/s1047951119003007.
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AbstractObjectives:The Ross procedure involves using the native pulmonary valve for aortic valve replacement then replacing the pulmonary valve with an allograft or xenograft. We aimed to compare our age-matched experience with the bovine jugular vein conduit and the pulmonary homograft for pulmonary valve replacement during the Ross procedure in children.Methods:Between 1998 and 2016, 15 patients <18 years of age underwent a Ross procedure using the bovine jugular vein conduit (Ross-Bovine Jugular Vein Conduit) at our institution. These patients were age-matched with 15 patients who had the Ross operation with a standard pulmonary homograft for right ventricular outflow tract reconstruction (Ross-Pulmonary Homograft). Paper and electronic medical records were retrospectively reviewed.Results:The median age of the Ross-Bovine Jugular Vein Conduit and Ross-Pulmonary Homograft patients were 4.8 years (interquartile range 1.1–6.6) and 3.3 years (interquartile 1.2–7.6), respectively (p = 0.6). The median follow-up time for the Ross-Bovine Jugular Vein Conduit and Ross-Pulmonary Homograft groups were 1.7 years (interquartile range 0.5–4.9) and 6.8 years (interquartile range 1.9–13.4), respectively (p = 0.03). Overall, 5-year survival, freedom from redo aortic valve replacement, and freedom from pulmonary valve replacement were similar between groups.Conclusion:The bovine jugular vein conduit and pulmonary homograft have favourable mid-term durability when used for right ventricular outflow tract reconstruction for the Ross operation. The bovine jugular vein conduit may be a suitable replacement for appropriately sized patients undergoing a Ross aortic valve replacement, though longer follow-up is needed.
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Seese, Laura M., Harma K. Turbendian, Carlos E. Diaz Castrillon, and Victor O. Morell. "The Fate of Homograft Versus Polytetrafluoroethylene Conduits After Neonatal Truncus Arteriosus Repair." World Journal for Pediatric and Congenital Heart Surgery 11, no. 2 (2020): 141–47. http://dx.doi.org/10.1177/2150135119888141.
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Background: Despite significant improvement in outcomes with truncus arteriosus (TA) repair, right ventricular outflow tract (RVOT) reconstruction with a right ventricular to pulmonary artery (RV-to-PA) conduit remains a source of long-term reintervention and reoperation. This study evaluated our experience with reintervention in homograft and polytetrafluoroethylene (PTFE) RV-to-PA conduits in neonates. Methods: Primary TA repairs from 2004 to 2016 at a single institution were included. Stratification was based on RVOT reconstruction with PTFE or homograft conduit. Primary outcome was operative conduit replacement. Secondary outcomes included the rates and types of catheter-based conduit interventions. Results: Twenty-eight patients underwent primary TA repair and 89.3% (n = 25) of them had RVOT reconstruction with a homograft (28.0%, n = 7) or PTFE (72.0%, n = 18) conduit. Rates of reoperation for conduit replacement and catheter-based interventions were similar between those with PTFE and homograft conduits (85.7% vs 72.2%, P = .49 and 57.1% vs 83.3%, P = .11, respectively). Additionally, the median time to conduit replacement and catheter-based conduit interventions were comparable. In multivariable analysis, conduit size, but not conduit type, was a predictor of conduit revision (hazard ratio: 1.66, 95% confidence interval: 1.11-2.49, P = .02). At five-year and ten-year follow-up, patients with PTFE conduits had better survival than those with homograft conduits (100.0% vs 71.4%, P = .02); however, no mortalities were associated with conduit reoperations or catheter-based reinterventions. Conclusions: Polytetrafluoroethylene and homograft RVOT reconstruction in neonatal TA repair demonstrate similar durability as defined by reoperation and reintervention rates. The validation of the durability of PTFE conduits in neonatal TA repair requires confirmatory studies in larger cohorts.
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Kim, Ah Young, Jo Won Jung, Se Yong Jung, et al. "Early Outcomes of Percutaneous Pulmonary Valve Implantation with Pulsta and Melody Valves: The First Report from Korea." Journal of Clinical Medicine 9, no. 9 (2020): 2769. http://dx.doi.org/10.3390/jcm9092769.
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Percutaneous pulmonary valve implantation (PPVI) is used to treat pulmonary stenosis (PS) or pulmonary regurgitation (PR). We described our experience with PPVI, specifically valve-in-valve transcatheter pulmonary valve replacement using the Melody valve and novel self-expandable systems using the Pulsta valve. We reviewed data from 42 patients undergoing PPVI. Twenty-nine patients had Melody valves in mostly bioprosthetic valves, valved conduits, and homografts in the pulmonary position. Following Melody valve implantation, the peak right ventricle-to-pulmonary artery gradient decreased from 51.3 ± 11.5 to 16.7 ± 3.3 mmHg and right ventricular systolic pressure fell from 70.0 ± 16.8 to 41.3 ± 17.8 mmHg. Thirteen patients with native right ventricular outflow tract (RVOT) lesions and homograft underwent PPVI with the new self-expandable Pulsta valve—a nitinol wire stent mounted with a trileaflet porcine pericardial valve. Following Pulsta valve implantation, cardiac magnetic resonance imaging showed a decreased PR fraction and that the right ventricular end-diastolic volume index decreased from 166.1 ± 11.9 to 123.6 ± 12.4 mL/m2. There were no mortality, severe procedural morbidity, or valve-related complications. At the mean 14.2 month (4–57 months) follow-up, no patients had more than mild PR. PPVI using Melody and Pulsta valves was first shown to provide excellent early outcomes without serious adverse event in most patients with RVOT dysfunction in Korea.
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Ram, Duvuru, Geevarghese Mathew, Christopher Lewis, et al. "Lung transplant graft salvage using aortic homograft for bronchial dehiscence." Interactive CardioVascular and Thoracic Surgery 31, no. 5 (2020): 664–66. http://dx.doi.org/10.1093/icvts/ivaa173.
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Abstract The use of aortic homograft in infective pathology is well described. Its use in the repair of post-transplant airway complications has been seldom reported. Herein, we report our experience with the successful use of aortic homograft in the management of post-transplant large airway complications in two patients.
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Shaddy, Robert E., Lloyd Y. Tani, Jane E. Sturtevant, Linda M. Lambert, and Edwin C. McGough. "Effects of homograft blood type and anatomic type on stenosis, regurgitation and calcium in homografts in the pulmonary position." American Journal of Cardiology 70, no. 3 (1992): 392–93. http://dx.doi.org/10.1016/0002-9149(92)90627-b.
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Ditkowski, Bartosz, Kirsten Leeten, Ramadan Jashari, Elizabeth Jones, and Ruth Heying. "Staphylococcus aureus adheres avidly to decellularised cardiac homograft tissue in vitro in the fibrinogen-dependent manner." Cardiology in the Young 30, no. 12 (2020): 1783–87. http://dx.doi.org/10.1017/s1047951120002772.
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AbstractObjective:Infective endocarditis remains a severe complication associated with a high morbidity and mortality in patients after heart valve replacement. Exploration of the pathogenesis is of high demand and we, therefore, present a competent model that allows studying bacterial adherence and the role of plasma fibrinogen in this process using a new in-house designed low-volume flow chamber. Three cardiac graft tissues used for pulmonary valve replacement have been tested under shear conditions to investigate the impact of surface composition on the adhesion events.Methods:Tissue pieces of cryopreserved homograft (non-decellularised), decellularised homograft and bovine pericardium patch were investigated for fibrinogen binding. Adherence of Staphylococcus aureus to these graft tissues was studied quantitatively under flow conditions in our newly fabricated chamber based on a parallel plates’ modality. The method of counting colony-forming units was reliable and reproducible to assess the propensity of different graft materials for bacterial attachment under shear.Results:Bacterial perfusions over all plasma-precoated tissues identified cryopreserved homograft with the lowest affinity for S. aureus compared to decellularised homograft presenting a significantly higher bacterial adhesion (p < 0.05), which was linked to a more avid fibrinogen binding (p < 0.01). Bovine pericardial patch, as a reference tissue in this study, was confirmed to be the most susceptible tissue graft for the bacterial adhesion, which was in line with our previous work.Conclusion:The two studied homograft tissues showed different levels of bacterial attachment, which might be postulated by the involvement of fibrinogen in the adhesion mechanism(s) shown previously for bovine tissues.
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Hartyánszky, István, László Székely, László Szudi, et al. "Right ventricular outflow tract reconstruction in adolescents and adults after previous repair of congenital heart defects." Orvosi Hetilap 153, no. 31 (2012): 1219–24. http://dx.doi.org/10.1556/oh.2012.29428.
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Due to successful surgical treatment of congenital heart defects in infants and children, the number of patients who reach the adolescent/adult age is continuously increasing. Aims: The authors sought to identify the short- and medium-term outcomes of reconstruction of right ventricular outflow tract in adolescents and adults who underwent surgical intervention for congenital heart defect in infancy or early childhood. Methods: Between 2001 and 2012, 48 patients (age: 15–39, mean 21 years) (30 tetralogy of Fallot, 11 pulmonary atresia + ventricular septal defect, 6 transposition of great arteries + ventricular septal defect + left ventricular outflow tract obstruction, and 1 truncus arteriosus) had repeat operation because of right ventricular dysfunction. All patients previously underwent right ventricular outflow tract procedures in early childhood. Results: In 31 patients, the small homograft, and in 9 patients the transannular-paths were replaced for “adult-size” homograft. Bioprosthetic pulmonary valve replacement was performed in pulmonary (6 patients) and homograft annuli (2 patients). In 14 patients, resection of the right ventricular outflow tract aneurism was also necessary to be performed. There was no early and mid-time (10 years) mortality. In 97.5% of patients with homograft-re-implantation, there was no need for repeat intervention for 5 years. Conclusions: The right ventricular outflow tract restoration in adolescents and adults is an effective procedure. The reconstruction should be performed in early adolescent period to prevent right ventricular dysfunction. The authors prefer using bioprosthetic pulmonary valve replacement in patients with adult-size pulmonary or homograft annulus. Orv. Hetil., 2012, 153, 1219–1224.
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Wittwer, Erica D., Juan N. Pulido, Shane M. Gillespie, Frank Cetta, and Joseph A. Dearani. "Left Main Coronary Artery Compression following Melody Pulmonary Valve Implantation: Use of Impella Support as Rescue Therapy and Perioperative Challenges with ECMO." Case Reports in Critical Care 2014 (2014): 1–3. http://dx.doi.org/10.1155/2014/959704.
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The purpose of this case is to describe the complex perioperative management of a 30-year-old woman with congenital heart disease and multiple resternotomies presenting with pulmonary homograft dysfunction and evaluation for percutaneous pulmonary valve replacement. Transvenous, transcatheter Melody valve placement caused left main coronary artery occlusion and cardiogenic shock. An Impella ventricular assist device (VAD) provided rescue therapy during operating room transport for valve removal and pulmonary homograft replacement. ECMO support was required following surgery. Several days later during an attempted ECMO wean, her hemodynamics deteriorated abruptly. Transesophageal and epicardial echocardiography identified pulmonary graft obstruction, requiring homograft revision due to large thrombosis. This case illustrates a role for Impella VAD as bridge to definitive procedure after left coronary occlusion and describes management of complex perioperative ECMO support challenges.
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Demkow, Marcin, Witold Rużyłło, Elżbieta K. Biernacka, Jacek Różański, and Mariusz Kuśmierczyk. "Is the “porcellain homograft” a contraindication for transcatheter pulmonary valve implantation? A." Advances in Interventional Cardiology 4 (2011): 323–26. http://dx.doi.org/10.5114/pwki.2011.25794.
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Gonzalez de Alba, Cesar, Fernando Molina Berganza, John Brownlee, Muhammad Khan, and Dilachew Adebo. "Cardiac Magnetic Resonance to Evaluate Percutaneous Pulmonary Valve Implantation in Children and Young Adults." Texas Heart Institute Journal 45, no. 2 (2018): 63–69. http://dx.doi.org/10.14503/thij-16-6100.
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Experience with cardiac magnetic resonance to evaluate coronary arteries in children and young adult patients is limited. Because noninvasive imaging has advantages over coronary angiography, we compared the effectiveness of these techniques in patients who were being considered for percutaneous pulmonary valve implantation. We retrospectively reviewed the cases of 26 patients (mean age, 12.53 ± 4.85 yr; range, 5–25 yr), all of whom had previous right ventricular-to-pulmonary artery homografts. We studied T2-prepared whole-heart images for coronary anatomy, velocity-encoded cine images for ventricular morphology, and function- and time-resolved magnetic resonance angiographic findings. Cardiac catheterization studies included coronary angiography, balloon compression testing, right ventricular outflow tract, and pulmonary artery anatomy. Diagnostic-quality images were obtained in 24 patients (92%), 13 of whom were considered suitable candidates for valve implantation. Two patients (8%) had abnormal coronary artery anatomy that placed them at high risk of coronary artery compression during surgery. Twelve patients underwent successful valve implantation after cardiac magnetic resonance images and catheterization showed no increased risk of compression. We attempted valve implantation in one patient with unsuitable anatomy but ultimately placed a stent in the homograft. Magnetic resonance imaging of coronary arteries is an important noninvasive study that may identify patients who are at high risk of coronary artery compression during percutaneous pulmonary valve implantation, and it may reveal high-risk anatomic variants that can be missed during cardiac catheterization.
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Butany, Jagdish, Manmeet S. Ahluwalia, Vidhya Nair, and Tirone E. David. "Cryopreserved pulmonary homograft." Cardiovascular Pathology 13, no. 1 (2004): 59–61. http://dx.doi.org/10.1016/s1054-8807(03)00092-9.
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Almassi, G. Hossein. "Cryopreserved Pulmonary Homograft." Journal of Cardiac Surgery 7, no. 2 (1992): 192. http://dx.doi.org/10.1111/j.1540-8191.1992.tb00798.x.
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Chaukar, Arvind P., Anil M. Patwardhan, Ajay Kaul, and Shirish S. Borker. "Homograft valve revisited." Indian Journal of Thoracic and Cardiovascular Surgery 9, no. 2 (1993): 78–80. http://dx.doi.org/10.1007/bf02666028.
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Chiesa, R., D. Astore, G. Piccolo, et al. "Fresh and Cryopreserved Arterial Homografts in the Treatment of Prosthetic Graft Infections: Experience of the Italian Collaborative Vascular Homograft Group." Annals of Vascular Surgery 12, no. 5 (1998): 457–62. http://dx.doi.org/10.1007/s100169900184.
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Alsidawi, Said, Kevin L. Greason, Gurpreet S. Sandhu, Joseph F. Malouf, and Krishnaswamy Chandrasekaran. "Percutaneous valve-in-homograft for management of a failed homograft." European Heart Journal – Cardiovascular Imaging 17, no. 10 (2016): 1190. http://dx.doi.org/10.1093/ehjci/jew138.
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Verma, Rajiv, Delores Danilowicz, and Stephen Colvin. "Reconstruction of the aortic arch in an adolescent female with complex congenital heart disease." Cardiology in the Young 4, no. 2 (1994): 164–67. http://dx.doi.org/10.1017/s1047951100002122.
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AbstractCoarctations of the aortic arch are rare, and when found, they are often associated with other complex congenital heart disease. An adolescent female with multiple coarctations of the aortic arch and ventricular septal defects underwent complete repair, entailing replacement of the aortic arch with a homograft and closure of the ventricular septal defects. The postoperative course was complicated by a tear in the homograft, possibly related to sepsis. After its resolution, her hemodynamic results remain excellent.