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Relevant bibliographies by topics / Homologous recombination repair

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Academic literature on the topic 'Homologous recombination repair'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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Journal articles on the topic "Homologous recombination repair"

1

Nowosielska, Anetta. "Bacterial DNA repair genes and their eukaryotic homologues: 5. The role of recombination in DNA repair and genome stability." Acta Biochimica Polonica 54, no. 3 (2007): 483–94. http://dx.doi.org/10.18388/abp.2007_3223.

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Recombinational repair is a well conserved DNA repair mechanism present in all living organisms. Repair by homologous recombination is generally accurate as it uses undamaged homologous DNA molecule as a repair template. In Escherichia coli homologous recombination repairs both the double-strand breaks and single-strand gaps in DNA. DNA double-strand breaks (DSB) can be induced upon exposure to exogenous sources such as ionizing radiation or endogenous DNA-damaging agents including reactive oxygen species (ROS) as well as during natural biological processes like conjugation. However, the bulk

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2

Kuzminov, Andrei. "Recombinational Repair of DNA Damage inEscherichia coli and Bacteriophage λ". Microbiology and Molecular Biology Reviews 63, № 4 (1999): 751–813. http://dx.doi.org/10.1128/mmbr.63.4.751-813.1999.

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SUMMARY Although homologous recombination and DNA repair phenomena in bacteria were initially extensively studied without regard to any relationship between the two, it is now appreciated that DNA repair and homologous recombination are related through DNA replication. In Escherichia coli, two-strand DNA damage, generated mostly during replication on a template DNA containing one-strand damage, is repaired by recombination with a homologous intact duplex, usually the sister chromosome. The two major types of two-strand DNA lesions are channeled into two distinct pathways of recombinational rep

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3

Kadyk, L. C., and L. H. Hartwell. "Sister chromatids are preferred over homologs as substrates for recombinational repair in Saccharomyces cerevisiae." Genetics 132, no. 2 (1992): 387–402. http://dx.doi.org/10.1093/genetics/132.2.387.

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Abstract A diploid Saccharomyces cerevisiae strain was constructed in which the products of both homolog recombination and unequal sister chromatid recombination events could be selected. This strain was synchronized in G1 or in G2, irradiated with X-rays to induce DNA damage, and monitored for levels of recombination. Cells irradiated in G1 were found to repair recombinogenic damage primarily by homolog recombination, whereas those irradiated in G2 repaired such damage preferentially by sister chromatid recombination. We found, as have others, that G1 diploids were much more sensitive to the

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Tamburini, Beth A., and Jessica K. Tyler. "Localized Histone Acetylation and Deacetylation Triggered by the Homologous Recombination Pathway of Double-Strand DNA Repair." Molecular and Cellular Biology 25, no. 12 (2005): 4903–13. http://dx.doi.org/10.1128/mcb.25.12.4903-4913.2005.

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ABSTRACT Many recent studies have demonstrated recruitment of chromatin-modifying enzymes to double-strand breaks. Instead, we wanted to examine chromatin modifications during the repair of these double-strand breaks. We show that homologous recombination triggers the acetylation of N-terminal lysines on histones H3 and H4 flanking a double-strand break, followed by deacetylation of H3 and H4. Consistent with a requirement for acetylation and deacetylation during homologous recombination, Saccharomyces cerevisiae with substitutions of the acetylatable lysines of histone H4, deleted for the N-t

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Bolt, Edward L., and Thorsten Allers. "New enzymes, new mechanisms?: DNA repair by recombination in the Archaea." Biochemist 26, no. 3 (2004): 19–21. http://dx.doi.org/10.1042/bio02603019.

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DNA repair by homologous recombination is highly accurate, since it uses an intact DNA strand to guide repair of its damaged homologue. This article focuses on two key steps in recombination: unwinding of strands by repair helicases, and annealing of homologous strands by strand-exchange enzymes.

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Inbar, Ori, and Martin Kupiec. "Homology Search and Choice of Homologous Partner during Mitotic Recombination." Molecular and Cellular Biology 19, no. 6 (1999): 4134–42. http://dx.doi.org/10.1128/mcb.19.6.4134.

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ABSTRACT Homologous recombination is an important DNA repair mechanism in vegetative cells. During the repair of double-strand breaks, genetic information is transferred between the interacting DNA sequences (gene conversion). This event is often accompanied by a reciprocal exchange between the homologous molecules, resulting in crossing over. The repair of DNA damage by homologous recombination with repeated sequences dispersed throughout the genome might result in chromosomal aberrations or in the inactivation of genes. It is therefore important to understand how the suitable homologous part

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Uchida, Tetsuya, Mariko Miyawaki, and Haruyasu Kinashi. "Chromosomal Arm Replacement in Streptomyces griseus." Journal of Bacteriology 185, no. 3 (2003): 1120–24. http://dx.doi.org/10.1128/jb.185.3.1120-1124.2003.

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ABSTRACT UV irradiation of Streptomyces griseus 2247 yielded a new chromosomal deletion mutant, MM9. Restriction and sequencing analysis revealed that homologous recombination between two similar lipoprotein-like open reading frames, which are located 450 and 250 kb from the left and right ends, respectively, caused chromosomal arm replacement. As a result, new 450-kb terminal inverted repeats (TIRs) were formed in place of the original 24-kb TIRs. Frequent homologous recombinations in Streptomyces strains suggest that telomere deletions can usually be repaired by recombinational DNA repair fu

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Sargent, R. G., M. A. Brenneman, and J. H. Wilson. "Repair of site-specific double-strand breaks in a mammalian chromosome by homologous and illegitimate recombination." Molecular and Cellular Biology 17, no. 1 (1997): 267–77. http://dx.doi.org/10.1128/mcb.17.1.267.

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In mammalian cells, chromosomal double-strand breaks are efficiently repaired, yet little is known about the relative contributions of homologous recombination and illegitimate recombination in the repair process. In this study, we used a loss-of-function assay to assess the repair of double-strand breaks by homologous and illegitimate recombination. We have used a hamster cell line engineered by gene targeting to contain a tandem duplication of the native adenine phosphoribosyltransferase (APRT) gene with an I-SceI recognition site in the otherwise wild-type APRT+ copy of the gene. Site-speci

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Sweigert, S. E., and D. Carroll. "Repair and recombination of X-irradiated plasmids in Xenopus laevis oocytes." Molecular and Cellular Biology 10, no. 11 (1990): 5849–56. http://dx.doi.org/10.1128/mcb.10.11.5849.

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Plasmid DNA substrates were X-irradiated and injected into the nuclei of Xenopus laevis oocytes. After incubation for 20 h, DNA was recovered from the oocytes and analyzed simultaneously for repair and for intermolecular homologous recombination by electrophoresis and bacterial transformation. Oocyte-mediated repair of DNA strand breaks was observed with both methods. Using a repair-deficient mutant Escherichia coli strain and its repair-proficient parent as hosts for the transformation assay, we also demonstrated that oocytes repaired oxidative-type DNA base damage induced by X-rays. X-irradi

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Sweigert, S. E., and D. Carroll. "Repair and recombination of X-irradiated plasmids in Xenopus laevis oocytes." Molecular and Cellular Biology 10, no. 11 (1990): 5849–56. http://dx.doi.org/10.1128/mcb.10.11.5849-5856.1990.

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Plasmid DNA substrates were X-irradiated and injected into the nuclei of Xenopus laevis oocytes. After incubation for 20 h, DNA was recovered from the oocytes and analyzed simultaneously for repair and for intermolecular homologous recombination by electrophoresis and bacterial transformation. Oocyte-mediated repair of DNA strand breaks was observed with both methods. Using a repair-deficient mutant Escherichia coli strain and its repair-proficient parent as hosts for the transformation assay, we also demonstrated that oocytes repaired oxidative-type DNA base damage induced by X-rays. X-irradi

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Dissertations / Theses on the topic "Homologous recombination repair"

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Chu, Wai Kit. "Genetic analysis of homologous recombination repair pathways." Thesis, University of Oxford, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.510942.

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Meddows, Tom Richard. "DNA breakage and repair in Escherichia coli." Thesis, University of Nottingham, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.250525.

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Mohindra, Atul. "Defects in homologous recombination repair in mismatch repair-deficient tumour cell lines." Thesis, University of Sheffield, 2004. http://etheses.whiterose.ac.uk/6062/.

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MMR-deficiency increases the rate of mutations and often sensitizes cells to DSB-inducing agents (e. g. camptothecin and etoposide) as well as MMC (Jacob et a/., 2001 and Fiumicino et al., 2000). MMR -deficient tumour cell lines are also sensitive to the cytotoxic effects thymidine (Mohindra et al., 2002). This sensitivity is not a direct consequence of MMR -deficiency or alterations of DNA precursor metabolism. Instead, the results described in the present study suggest that MMR -deficient cells are sensitive to thymidine as a result of defects in HRR. The ScNeo recombination reporter substra

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Gruver, Aaron Matthew. "Cellular Analyses of the RAD51-related Homologous Recombination Repair Proteins." University of Toledo Health Science Campus / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=mco1127144634.

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Saitou, Yuuichirou. "Regulatory mechanism of damage-dependent homologous recombination." Kyoto University, 2015. http://hdl.handle.net/2433/199392.

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Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(人間・環境学)<br>甲第19068号<br>人博第721号<br>新制||人||173(附属図書館)<br>26||人博||721(吉田南総合図書館)<br>32019<br>京都大学大学院人間・環境学研究科相関環境学専攻<br>(主査)教授小松賢志, 教授宮下英明, 准教授三浦智行<br>学位規則第4条第1項該当

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Smith, Laura Jayne. "Homologous recombination dependent repair of DNA damage in Drosophila melanogaster." Thesis, Lancaster University, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.444857.

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Wang, Xin. "PTIP promotes DNA double-strand break repair through homologous recombination." Kyoto University, 2010. http://hdl.handle.net/2433/120541.

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Davenport, Eric Parker. "Fluorescent Probes to Investigate Homologous Recombination Dynamics." DigitalCommons@USU, 2016. https://digitalcommons.usu.edu/etd/5007.

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There are multiple mechanisms by which DNA can become damaged. Such damage must be repaired for the cell to avoid ill-health consequences. Homologous recombination (HR) is a means of repairing one specific type of damage, a double-strand break (DSB). This complex pathway includes the Rad51-DNA nucleoprotein filament as its primary machinery. Current methodology for studying HR proteins includes the use of fluorescently labeled DNA to probe for HR dynamics. This technique limits the number of proteins that can be involved in experimentation, and often only works as an end reporter. The work her

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Tay, Ye Dee. "The analysis of homologous recombination pathways in Saccharomyces cerevisiae." Thesis, University of Oxford, 2010. http://ora.ox.ac.uk/objects/uuid:2832c80a-202d-4b92-9685-5570c25f7386.

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Homologous recombination (HR) is essential for the repair of DNA doublestrand breaks (DSBs) and damaged replication forks. However, HR can also cause gross chromosomal rearrangements (GCRs) by producing crossovers (COs), resulting in the reciprocal exchange of sequences between non-sister chromatids. Therefore, HR-mediated GCRs are suppressed via the promotion of HR pathways that favour noncrossover (NCO) formation, such as the synthesis-dependent strand annealing (SDSA) and dissolution pathways, which are modulated by Mph1 and Sgs1 helicases, respectively. The mismatch repair (MMR) pathway is

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Kyryk, Anzhela. "DSB repair by illegitimate and homologous DNA recombination in Arabidopsis thaliana." [S.l. : s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=96435859X.

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Books on the topic "Homologous recombination repair"

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Spies, Maria, and Anna Malkova. Mechanisms of DNA Recombination and Genome Rearrangements: Intersection Between Homologous Recombination, DNA Replication and DNA Repair. Elsevier Science & Technology Books, 2018.

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Mechanisms of DNA Recombination and Genome Rearrangements: Intersection between Homologous Recombination, DNA Replication and DNA Repair. Elsevier, 2018. http://dx.doi.org/10.1016/s0076-6879(18)x0003-2.

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Popova, Milena. Posttranslational Modifications of Rad51 Protein and Its Direct Partners: Role and Effect on Homologous Recombination - Mediated DNA Repair. INTECH Open Access Publisher, 2011.

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Book chapters on the topic "Homologous recombination repair"

1

Thacker, John. "Homologous Recombination Repair." In Encyclopedia of Cancer. Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-16483-5_2801.

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Thacker, John. "Homologous Recombination Repair." In Encyclopedia of Cancer. Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-642-27841-9_2801-2.

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Thacker, John. "Homologous Recombination Repair." In Encyclopedia of Cancer. Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-46875-3_2801.

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Whelan, Donna R., and Eli Rothenberg. "Super-Resolution Imaging of Homologous Recombination Repair at Collapsed Replication Forks." In Homologous Recombination. Springer US, 2020. http://dx.doi.org/10.1007/978-1-0716-0644-5_24.

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See, Colby, Deepak Arya, Emily Lin, and Irene Chiolo. "Live Cell Imaging of Nuclear Actin Filaments and Heterochromatic Repair foci in Drosophila and Mouse Cells." In Homologous Recombination. Springer US, 2020. http://dx.doi.org/10.1007/978-1-0716-0644-5_32.

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Sebesta, Marek, and Lumir Krejci. "Mechanism of Homologous Recombination." In DNA Replication, Recombination, and Repair. Springer Japan, 2016. http://dx.doi.org/10.1007/978-4-431-55873-6_4.

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Thacker, Drew, and Scott Keeney. "Homologous Recombination During Meiosis." In DNA Replication, Recombination, and Repair. Springer Japan, 2016. http://dx.doi.org/10.1007/978-4-431-55873-6_6.

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Holmes, Allyson, and James E. Haber. "Physical Monitoring of HO-Induced Homologous Recombination." In DNA Repair Protocols. Humana Press, 1999. http://dx.doi.org/10.1007/978-1-4612-1608-7_32.

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Smith, Gerald R., Susan K. Amundsen, Patrick Dabert, and Andrew F. Taylor. "The initiation and control of homologous recombination in Escherichia coli." In DNA Repair and Recombination. Springer Netherlands, 1995. http://dx.doi.org/10.1007/978-94-011-0537-8_2.

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West, Stephen C. "Formation, translocation and resolution of Holliday junctions during homologous genetic recombination." In DNA Repair and Recombination. Springer Netherlands, 1995. http://dx.doi.org/10.1007/978-94-011-0537-8_3.

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Conference papers on the topic "Homologous recombination repair"

1

Muvaffak, Asli, Yinghui Zhou, Bin Feng, et al. "Abstract A091: Targeting homologous recombination repair defects in lung cancer." In Abstracts: AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics; October 26-30, 2019; Boston, MA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1535-7163.targ-19-a091.

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Sharma, Vivek, Simran Khurana, Nard Kubben, et al. "Abstract PR03: A lncRNA regulates DNA repair by homologous recombination." In Abstracts: AACR Special Conference on Noncoding RNAs and Cancer: Mechanisms to Medicines; December 4-7, 2015; Boston, MA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.nonrna15-pr03.

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Dry, Jonathan R., Zhongwu Lai, Brian Dougherty, Carl Barrett, and Steven Criscione. "Abstract 5724: Homologous recombination repair gene mutations for DNA repair and immune oncology drug combinations." In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-5724.

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He, Yizhou Joseph, Khyati Meghani, and Dipanjan Chowdhury. "Abstract PR04: Mechanism for PARPi resistance: Homologous recombination without BRCA1." In Abstracts: AACR Special Conference on DNA Repair: Tumor Development and Therapeutic Response; November 2-5, 2016; Montreal, QC, Canada. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1557-3125.dnarepair16-pr04.

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Pires, Elena, Neelam Sharma, Claudia Wiese, Patrick Sung, and Weixing Zhao. "Abstract 1749: Investigating the role of RAD51AP1 in homologous recombination DNA repair." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.am2019-1749.

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Timms, Kirsten M., Victor Abkevich, Chris Neff, et al. "Abstract 1763: Frequency of homologous recombination repair defects across breast cancer subtypes." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-1763.

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Pires, Elena, Neelam Sharma, Claudia Wiese, Patrick Sung, and Weixing Zhao. "Abstract 1749: Investigating the role of RAD51AP1 in homologous recombination DNA repair." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-1749.

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Hilmi, Khalid, Chenxi Zhang, Zhenbao Yu, et al. "Abstract A12: CTCF facilitates DNA double-strand break repair by homologous recombination." In Abstracts: AACR Special Conference on DNA Repair: Tumor Development and Therapeutic Response; November 2-5, 2016; Montreal, QC, Canada. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1557-3125.dnarepair16-a12.

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Pond, Kelvin W., Christelle DeRenty, Mary Yagle, and Nathan Ellis. "Abstract A06: Regulation of homologous recombination by the SUMO ligase NSMCE2." In Abstracts: AACR Special Conference on DNA Repair: Tumor Development and Therapeutic Response; November 2-5, 2016; Montreal, QC, Canada. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1557-3125.dnarepair16-a06.

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Gröschel, Stefan, Daniel Hübschmann, Francesco Raimondi, et al. "Abstract 2723: Defective homologous recombination DNA repair as therapeutic target in advanced chordoma." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.am2019-2723.

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Reports on the topic "Homologous recombination repair"

1

Botev, Petar, and Anastas Gospodinov. Human SRCAP Is Involved in Late Stages of Homologous Recombination Repair. "Prof. Marin Drinov" Publishing House of Bulgarian Academy of Sciences, 2019. http://dx.doi.org/10.7546/crabs.2019.04.08.

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Bussen, Wendy L. The Roles of the BLM Helicase in Homologous Recombination and DNA Repair. Defense Technical Information Center, 2005. http://dx.doi.org/10.21236/ada436923.

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Jaskelioff, Mariela. Role of Chromatin Remodeling by RAD54 in DNA Damage Repair and Homologous Recombination. Defense Technical Information Center, 2003. http://dx.doi.org/10.21236/ada416619.

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Jaskelioff, Mariela, and Craig Peterson. Role of Chromatin Remodeling by RAD54 in DNA Damage Repair and Homologous Recombination. Defense Technical Information Center, 2004. http://dx.doi.org/10.21236/ada425895.

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Zafar, Faria, Sara B. Seidler, Amy Kronenberg, David Schild, and Claudia Wiese. Homologous recombination contributes to the repair of DNA double-strand breaks induced by high-energy iron ions. Office of Scientific and Technical Information (OSTI), 2010. http://dx.doi.org/10.2172/983115.

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Chen, David J. The Functions of BRCA2 in Homologous Recombinational Repair. Defense Technical Information Center, 2005. http://dx.doi.org/10.21236/ada443780.

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Chen, David J. The Functions of BRCA2 in Homologous Recombinational Repair. Defense Technical Information Center, 2004. http://dx.doi.org/10.21236/ada433049.

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Chen, David J. The Functions of BRCA2 in Homologous Recombinational Repair. Defense Technical Information Center, 2003. http://dx.doi.org/10.21236/ada420343.

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Chen, David J. The Functions of BRCA2 in Homologous Recombinational Repair. Defense Technical Information Center, 2006. http://dx.doi.org/10.21236/ada458474.

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Chen, David J. The Functions of BRCA2 in Homologous Recombinational Repair. Defense Technical Information Center, 2007. http://dx.doi.org/10.21236/ada473770.

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