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Relevant bibliographies by topics / Homologous recombination repair / Dissertations / Theses

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Dissertations / Theses on the topic 'Homologous recombination repair'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Chu, Wai Kit. "Genetic analysis of homologous recombination repair pathways." Thesis, University of Oxford, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.510942.

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2

Meddows, Tom Richard. "DNA breakage and repair in Escherichia coli." Thesis, University of Nottingham, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.250525.

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3

Mohindra, Atul. "Defects in homologous recombination repair in mismatch repair-deficient tumour cell lines." Thesis, University of Sheffield, 2004. http://etheses.whiterose.ac.uk/6062/.

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MMR-deficiency increases the rate of mutations and often sensitizes cells to DSB-inducing agents (e. g. camptothecin and etoposide) as well as MMC (Jacob et a/., 2001 and Fiumicino et al., 2000). MMR -deficient tumour cell lines are also sensitive to the cytotoxic effects thymidine (Mohindra et al., 2002). This sensitivity is not a direct consequence of MMR -deficiency or alterations of DNA precursor metabolism. Instead, the results described in the present study suggest that MMR -deficient cells are sensitive to thymidine as a result of defects in HRR. The ScNeo recombination reporter substra

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4

Gruver, Aaron Matthew. "Cellular Analyses of the RAD51-related Homologous Recombination Repair Proteins." University of Toledo Health Science Campus / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=mco1127144634.

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5

Saitou, Yuuichirou. "Regulatory mechanism of damage-dependent homologous recombination." Kyoto University, 2015. http://hdl.handle.net/2433/199392.

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Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(人間・環境学)<br>甲第19068号<br>人博第721号<br>新制||人||173(附属図書館)<br>26||人博||721(吉田南総合図書館)<br>32019<br>京都大学大学院人間・環境学研究科相関環境学専攻<br>(主査)教授小松賢志, 教授宮下英明, 准教授三浦智行<br>学位規則第4条第1項該当

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6

Smith, Laura Jayne. "Homologous recombination dependent repair of DNA damage in Drosophila melanogaster." Thesis, Lancaster University, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.444857.

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7

Wang, Xin. "PTIP promotes DNA double-strand break repair through homologous recombination." Kyoto University, 2010. http://hdl.handle.net/2433/120541.

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8

Davenport, Eric Parker. "Fluorescent Probes to Investigate Homologous Recombination Dynamics." DigitalCommons@USU, 2016. https://digitalcommons.usu.edu/etd/5007.

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There are multiple mechanisms by which DNA can become damaged. Such damage must be repaired for the cell to avoid ill-health consequences. Homologous recombination (HR) is a means of repairing one specific type of damage, a double-strand break (DSB). This complex pathway includes the Rad51-DNA nucleoprotein filament as its primary machinery. Current methodology for studying HR proteins includes the use of fluorescently labeled DNA to probe for HR dynamics. This technique limits the number of proteins that can be involved in experimentation, and often only works as an end reporter. The work her

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9

Tay, Ye Dee. "The analysis of homologous recombination pathways in Saccharomyces cerevisiae." Thesis, University of Oxford, 2010. http://ora.ox.ac.uk/objects/uuid:2832c80a-202d-4b92-9685-5570c25f7386.

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Homologous recombination (HR) is essential for the repair of DNA doublestrand breaks (DSBs) and damaged replication forks. However, HR can also cause gross chromosomal rearrangements (GCRs) by producing crossovers (COs), resulting in the reciprocal exchange of sequences between non-sister chromatids. Therefore, HR-mediated GCRs are suppressed via the promotion of HR pathways that favour noncrossover (NCO) formation, such as the synthesis-dependent strand annealing (SDSA) and dissolution pathways, which are modulated by Mph1 and Sgs1 helicases, respectively. The mismatch repair (MMR) pathway is

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10

Kyryk, Anzhela. "DSB repair by illegitimate and homologous DNA recombination in Arabidopsis thaliana." [S.l. : s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=96435859X.

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11

Xiao, Yu Xuan. "Investigation of the relationship between Fanconi anaemia and homologous recombination repair." Thesis, University of Liverpool, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.533907.

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12

Blaikley, Elizabeth Jane. "Analysis of nucleotide synthesis and homologous recombination repair in Schizosaccharomyces pombe." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:2fcd2cab-e8bc-4164-8068-5c50af5f91e4.

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Nucleotide synthesis is a conserved and highly regulated response to DNA damage, required for the efficient repair of DNA double strand breaks (DSB) by homologous recombination (HR). This is essential to prevent loss of heterozygosity (LOH) and maintain genome stability. The aim of this study was to identify new genes important for HR through roles in damage-induced nucleotide synthesis. A screen was performed to identify S. pombe gene deletion strains whose DSB sensitivity was suppressed by deleting the ribonucleotide reductase (RNR) inhibitor spd1<sup>+</sup> to promote nucleotide synthesis.

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13

Braybrooke, Jeremy P. "Characterisation of human homologues of the RAD51 protein." Thesis, Oxford Brookes University, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.340870.

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14

Smiraldo, Phillip G. "The Rad51d DNA Repair Gene is Required for Chromosome and Telomore Stability in Mammalian Cells." University of Toledo Health Science Campus / OhioLINK, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=mco1146675938.

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15

Rafii, Seyed Saeed. "The role of variants of homologous recombination repair genes in breast cancer susceptibility and DNA repair." Thesis, University of Sheffield, 2003. http://etheses.whiterose.ac.uk/6137/.

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Apart from being the most common malignancy in women worldwide, breast cancer is also one of the most extensively investigated human cancers. The breast cancer susceptibility genes, BRCA1 and BRCA2 are responsible for less than 10% of breast cancer cases. However the genetic basis of the majority of breast cancer has not yet been identified. Since an acquired genetic instability resulting from the defects in DNA repair is known to promote tumorigenesis, a proportion of inherited breast cancers might be attributable to mutations in the genes involved in these functions. Homologous Recombination

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16

Al-Minawi, Ali Zuhair. "The role of ERCC1 in homologous recombination and inter-strand cross-link repair." Thesis, University of Sheffield, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.500265.

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17

Scorah, Jennifer Susan. "Phenotypic consequences of mutations in homologous recombination repair genes in colorectal cancer cells." Thesis, University of Sheffield, 2003. http://etheses.whiterose.ac.uk/6052/.

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The DNA damage response is important for maintaining genomic integrity following introduction of double-strand breaks (DSB) since illegitimate or incorrect repair of a DSB could promote malignant transformation. Mismatch-repair (MMR) deficient tumour cell lines are acutely sensitive to thymidine treatment and fail to activate homologous recombination (HR) repair following a DSB (Mohindra et al., 2002). Therefore, it was hypothesised that loss of HR repair may occur as a downstream event in tumours already deficient in MMR. The primary aim was to determine whether there were somatic mutations i

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18

Hussain, Shobbir. "Characterisation of the fanconi anaemia pathway and its role in homologous recombination repair." Thesis, King's College London (University of London), 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.413559.

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19

Amunugama, Ravindra Bandara. "Insights into Regulation of Human RAD51 Nucleoprotein Filament Activity During Homologous Recombination." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1321984760.

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20

Nandi, Saikat. "Deciphering the molecular mechanism by which Fml1 promotes and constrains homologous recombination." Thesis, University of Oxford, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.561123.

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Homologous Recombination (HR) can promote genome stability through its capacity to faithfully repair DNA gouble 2trand !;!reak2 (DSBs) and preventing the demise of stalled replication forks in part by catalysing template switching to enable DNA polymerase to bypass lesions. Despite these beneficial roles, inappropriate or untimely HR events can have deleterious consequences. HR can cause genome instability by recombining "inappropriate" homologous sequences, especially if the recombination intermediates are resolved to form crossovers. Over the past few years, study of the rare inherited chrom

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21

Song, Fei [Verfasser]. "Optimizing DNA double strand break repair for homologous recombination based gene therapy / Fei Song." Gießen : Universitätsbibliothek, 2017. http://d-nb.info/113251049X/34.

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22

Kingham, Guy L. "Screening for inhibitors of and novel proteins within the homologous recombination DNA repair pathway." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:e2988d0b-c6d4-42a8-aef9-f320a13d6391.

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The homologous recombination (HR) pathway of DNA repair is essential for the faithful repair of double-stranded DNA breaks (DSBs) in all organisms and as such helps maintain genomic stability. Furthermore, HR is instrumental in the cellular response to exogenous DNA damaging agents such as those used in the clinic for chemo- and radiotherapy. HR in humans is a complex, incompletely understood process involving numerous stages and diverse biochemical activities. Advancing our knowledge of the HR pathway in humans aids the understanding of how chemo- and radiotherapies act and may be used to dev

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23

Medhi, Darpan K. "The repair of DSBs catalyzed by VMA1 derived endonuclease by homologous recombination during meiosis." Thesis, University of Sheffield, 2013. http://etheses.whiterose.ac.uk/5721/.

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Homologous recombination (HR) during meiosis is initiated by programmed DNA double strand breaks (DSBs). Some of these DSBs are repaired to give crossovers (COs), which connect maternal and paternal homologous chromosomes and thus ensure proper segregation during meiosis I. In contrast, HR in mitotic cells forms mostly noncrossovers (NCOs); this prevents deleterious genome rearrangement and loss of heterozygosity. Therefore, meiotic HR is regulated to enrich for COs, but much remains to be understood regarding the basis of this regulation. Meiotic cells express unique HR proteins, and these gl

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24

Moss, Jennifer. "Identification and characterisation of homologous recombination genes in Schizosaccharomyces pombe." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:3f2f12d1-64b9-496a-ba1e-5c464e89c7b7.

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DNA double-strand breaks (DSBs) are highly genotoxic lesions, which can promote chromosomal rearrangements and tumorigenesis through oncogene activation or loss of heterozygosity (LOH) at tumour suppressor loci. To identify new genes involved in DSB repair and genome stability, an S. pombe deletion library was screened for mutants which exhibited sensitivity to the DNA damaging agents bleomycin and/or MMS. 192 mutants were isolated which exhibited increased sensitivity to one or both of these agents. These mutants were further analysed in a sectoring assay and mutants sought which exhibited el

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25

Ronson, George. "Investigation into the relationship between PARPs in DNA repair and synthetic lethality with homologous recombination deficiency." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:29e88ce0-a284-4537-983b-18ba364d4b3a.

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The genome of each cell is under constant threat from various forms of DNA damage. In order to protect themselves from this danger, cells possess a number of pathways able to resolve DNA lesions. The addition of poly(ADPribose) is a post-translational modification produced by attaching successive ADP-ribose moieties to a protein acceptor, forming long chains. Enzymes called poly(ADP-ribose) polymerases (PARPs) catalyse the production of these modifications, and a number of different PARPs have been linked to the process of DNA repair, including PARP1, PARP2 and PARP3. How these enzymes might f

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26

Duro, Eris. "Identification of MMS22 as a regulator of DNA repair." Thesis, University of Dundee, 2010. https://discovery.dundee.ac.uk/en/studentTheses/7b553aeb-8f92-492e-b16f-c4c96d36fb01.

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Obstacles such as DNA damage can block the progression of DNA replication forks. This is a major source of genome instability that can lead to cell transformation or death. The budding yeast MMS1 and MMS22 genes were identified in a screen for mutants that were hypersensitive to DNA alkylation that blocks replisome progression. I set out to investigate the cellular roles of these genes and found that cells lacking MMS1 or MMS22 are hypersensitive to a wide variety of genotoxins that stall or block replication forks, and are severely defective in their ability to recover from DNA alkylation dam

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27

Dever, Seth. "The Role of BRCA1 in DNA Double-strand Break Repair." VCU Scholars Compass, 2009. http://scholarscompass.vcu.edu/etd/1741.

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Mutations in the breast cancer susceptibility 1 (BRCA1) gene are linked to breast as well as ovarian cancers. However, most cancer-causing mutations within the BRCA1 gene have been found in the N’ and C’ terminal regions of the BRCA1 protein, both believed to be important for DNA double-strand break (DSB) repair. The BRCA1 C’ terminal (BRCT) repeats have been implicated in phospho-serine protein binding whereas the N’ terminal RING domain interacts with the BARD1 protein to form a hetero-dimeric complex with E3 ubiquitin ligase activity. The BRCA1 BRCT domain binds CtIP, BACH1, and RAP80, a

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28

Birkelbach, Moritz [Verfasser], and Jochen [Akademischer Betreuer] Dahm-Daphi. "Detection of Impaired Homologous Recombination Repair inNSCLC Cells and Tissues / Moritz Birkelbach. Betreuer: Jochen Dahm-Daphi." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2013. http://d-nb.info/1038789923/34.

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29

Mbewe, Moses. "The effect of RecA concentration on DNA repair and homologous recombination in Escherichia coli K-12." Thesis, University of Cambridge, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.338270.

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30

Li, Jian. "Mechanism of DNA Homologous Recombination through Studies of DNA Sliding Clamps, Clamp Loaders, and DNA Polymerases." Ohio University / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1374835449.

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31

Azeroglu, Benura. "DNA synthesis during double-strand break repair in Escherichia coli." Thesis, University of Edinburgh, 2015. http://hdl.handle.net/1842/16213.

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Efficient and accurate repair of DNA double strand breaks (DSBs) is required to maintain genomic stability in both eukaryotes and prokaryotes. In Escherichia coli, DSBs are repaired by homologous recombination (HR). During this process, DNA synthesis needs to be primed and templated from an intact homologous sequence to restore any information that may have been lost on the broken DNA molecule. Two critical late stages of the pathway are repair DNA synthesis and the processing of Holliday junctions (HJs). However, our knowledge of the detailed mechanisms of these steps is still limited. Our la

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32

Moreira, Tavares Eliana. "Mechanistic Study of D-loop Formation during Homologous Recombination by Molecular Microscopy." Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLS306.

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La Recombinaison Homologue (RH) est une des voies majeures, hautement fidèle, de réparation des cassures double brin de l’ADN et du redémarrage des fourches de réplication arrêtées ou bloquées. La RH utilise une séquence homologue pour réparer avec précision l'ADN. Elle est essentielle pour le maintien de la stabilité des génomes dans tous les organismes et également pour assurer la transmission et l'échange de l'information génétique pendant la méiose. L'étude mécanistique de la RH est importante pour comprendre l'instabilité génétique, la perte d'hétérozygotie, les aberrations chromosomiques

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33

Drew, Yvette Claire. "The potential of the PARP-1 inhibitor, AGO14699, in human cancers defective in homologous recombination DNA repair." Thesis, University of Newcastle upon Tyne, 2012. http://hdl.handle.net/10443/1551.

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The aims of this study were to undertake the first comprehensive in vitro, in vivo and clinical investigation into the effects of the PARP-1 inhibitor, AG014699, in human cancers defective in homologous recombination (HR) DNA double strand break (DSB) repair. HR deficient cells were 9-fold more sensitive to AG014699 than HR proficient cells (mean LC50 = 3.26 μM vs. 29.68; P < 0.0001), confirming the theory of synthetic lethality. BRCA1 methylated UACC3199 breast cancer cells were also sensitive to AG014699 with mean LC50 significantly lower than the HR proficient cells (7.6 μM vs. 29.68; P = 0

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34

Smith, Eric A. B. S. "DEK is a Homologous Recombination DNA Repair Protein and Prognostic Marker for a Subset of Oropharyngeal Carcinomas." University of Cincinnati / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ucin150480040523791.

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35

Cukras, Scott. "Promoting Genome Stability via Multiple DNA Repair Pathways." Scholar Commons, 2015. https://scholarcommons.usf.edu/etd/5470.

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Maintaining genome integrity is indispensible for cells to prevent and limit accruement of deleterious mutations and to promote viable cell growth and proliferation. Cells possess a myriad of mechanisms to detect, prevent and repair incurred cellular damage. Here we discuss various proteins and their accompanying cellular pathways that promote genome stability. We first investigate the NEDD8 protein and its role in promoting homologous recombination repair via multiple Cullin E3 ubiquitin ligases. We provide specific mechanisms through which, UBE2M, an E2 conjugating enzyme, neddylates various

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36

Tichy, Elisia D. "Double-Strand DNA Break Repair By Homologous Recombination Contributes To The Preservation of Genomic Stability In Mouse Embryonic Stem Cells." University of Cincinnati / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1265989840.

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37

Langland, Gregory Todd. "Interaction Between the BLM Helicase and the DNA Mismatch Repair Protein, MLH1." University of Cincinnati / OhioLINK, 2003. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1052316756.

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38

Dai, Dingli. "Caractérisation des interactions physiques et fonctionnelles entre le facteur d’assemblage de la chromatine, CAF-1, et des facteurs de la recombinaison homologue au cours de la réparation de l’ADN." Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLS498/document.

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L’ADN est constamment exposé à des insultes génotoxiques endogènes et exogènes. Plusieurs mécanismes de réparations de l’ADN sont mis en œuvre pour préserver la stabilité du génome et de l’épigénome. La recombinaison homologue (RH) joue un rôle central dans la réparation des cassures double brin de l’ADN (DSBs) et le redémarrage des fourches de réplication en réponse à un stress réplicatif. Ces deux processus sont tous deux couplés à l’assemblage de la chromatine. Le facteur d’assemblage de la chromatine 1 (CAF-1) est un chaperon d’histone conservé au cours de l’évolution qui fonctionne dans l

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39

Nguyen, Ngoc Hoa. "BRCA1 and CtIP Are Both Required to Recruit Dna2 at Double-Strand Breaks in Homologous Recombination." Kyoto University, 2016. http://hdl.handle.net/2433/215381.

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40

Tittcomb, Kay. "Examining the role of the mismatch repair system : the barrier to non-homologous recombination in meiosis and mitosis." Thesis, University of Sheffield, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.487637.

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Meiosis js a requirement of sexual reproduction. Prophase I of the first meiotic division is characterised by segregation of homologous chromosomes from one another and by the process of recombination. Homologous recombination, initiate by a DNA double strand break is a means by which the homologous chromosomes become physically linked to one another and can then correctly attach to the meiotic spindle. Choice of a suitable template for repair of the double strand break is vital to the integrity of the genome. The mismatch repair (MMR) system is an evolutionarily conserved repair process which

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41

Inano, Shojiro. "The E3 ligase RFWD3 promotes timely removal of both RPA and RAD51 from DNA damage sites to facilitate homologous recombination." Kyoto University, 2017. http://hdl.handle.net/2433/227591.

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42

Caceres, Valentina Celeste. "Regulation and Targeting of the FANCD2 Activation in DNA Repair." Scholar Commons, 2015. http://scholarcommons.usf.edu/etd/5652.

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Fanconi anemia (FA) is a genome instability syndrome that is clinically manifested by bone marrow failure, congenital defects, and elevated cancer susceptibility. The FA pathway is known to regulate the repair of DNA interstrand crosslinks in part through DNA homologous recombination (HR) repair. Up to today 16 FA proteins have been discovered that may participate in the common pathway. Cells that have mutations in the FA genes are hypersensitive to DNA damaging agents and display chromosome instability. A key regulatory event in the FA pathway is monoubiquitination of FANCD2-FANCI heterodimer

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43

Tsouroula, Aikaterini. "Double strand break repair within constitutive heterochromatin." Thesis, Strasbourg, 2017. http://www.theses.fr/2017STRAJ036/document.

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L'hétérochromatine, de nature compacte et répétitive, limite l’accès à l'ADN et fait de la réparation des DSBs un processus difficile que les cellules doivent surmonter afin de maintenir leur intégrité génomique. Pour y étudier la réparation des DSBs, nous avons conçu un système CRISPR / Cas9 dans lequel les DSB peuvent être efficacement et spécifiquement induites dans l'hétérochromatine de fibroblastes de souris NIH3T3. En développant un système CRISPR / Cas9 hautement spécifique et robuste pour cibler l'hétérochromatine péricentrique, nous avons montré que les DSB en G1 sont positionnellemen

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44

Mohammadian, Gol Tahereh [Verfasser]. "Role of Akt signaling in homologous recombination-dependent repair of radiation-induced DNA double strand breaks / Tahereh Mohammadian Gol." Tübingen : Universitätsbibliothek Tübingen, 2020. http://d-nb.info/1219064459/34.

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45

Md, Maminur Rahman. "Genetic Evidence for the Involvement of Mismatch Repair Proteins, PMS2 and MLH3, in a Late Step of Homologous Recombination." Doctoral thesis, Kyoto University, 2021. http://hdl.handle.net/2433/263575.

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付記する学位プログラム名: 充実した健康長寿社会を築く総合医療開発リーダー育成プログラム<br>京都大学<br>新制・課程博士<br>博士(医科学)<br>甲第23114号<br>医科博第125号<br>京都大学大学院医学研究科医科学専攻<br>(主査)教授斎藤通紀, 教授篠原隆司, 教授滝田順子<br>学位規則第4条第1項該当<br>Doctor of Medical Science<br>Kyoto University<br>DFAM

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46

Puthiyaveetil, Abdulkader Abdul Gafoor. "Altered Kinetics of Non-Homologous End Joining Mediated DNA Repair in Mouse Models of Aging and Leukemia." Diss., Virginia Tech, 2012. http://hdl.handle.net/10919/77233.

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DNA encodes the genetic instructions for the development and function of organisms and hence maintaining genomic integrity is essential for the propagation of life. However, DNA molecules are under constant threat of metabolic and environmental insults resulting in DNA damages including DNA double strand breaks (DSB), which are considered as a serious threat to cell survival. The majority of these DSB are repaired by Non-homologous end joining (NHEJ). Unrepaired DSB can lead to genomic instability resulting in cell cycle arrest, apoptosis, and mutations. Thus, delineating this DNA repair proce

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47

Goldstein, Eric D. "Analysis of the repair of topoisomerase II DNA damage." Honors in the Major Thesis, University of Central Florida, 2011. http://digital.library.ucf.edu/cdm/ref/collection/ETH/id/385.

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A large number of anti-cancer chemotherapeutics target DNA topoisomerases. Etoposide is a specific topoisomerase II poison which causes reversible double strand DNA breaks. The focus of this project is to analyze the repair of DNA damage induced by etoposide.. Double strand DNA break repair is mediated by through either non-homologous end joining (NHEJ) or homologous recombination. NHEJ repairs through direct ligation of a double stranded break while homologous recombination utilizes a homologous template to recover the wild type sequence. A reporter cassette, RYDR-GFP, has been stably integra

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48

Khade, Nilesh V. "A Study of DNA Homologous Recombination Mechanism through Biochemical Characterization of Rad52 and BRCA2 in Yeast and Humans." Ohio University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1437664889.

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49

Boyko, Oleksandr, and University of Lethbridge Faculty of Arts and Science. "The versatile role of homologous recombination in plant cell : repair of DNA damage, stress-directed genome evolution and foreign DNA integration." Thesis, Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2008, 2008. http://hdl.handle.net/10133/724.

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Homologous recombination represents a DNA repair pathway. Its role in a plant cell is not limited to double strand break repair. It also extends to genome evolution via rearranging of DNA sequences, and has an important application in foreign DNA integration in the plant genome. Our study demonstrated that effects exerted by stress on homologous recombination and genome stability are not restricted to the exposed generation. The progeny of plants exposed to stress exhibited elevated spontaneous homologous recombination, changes in DNA methylation and higher tolerance to stress. These heritable

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Zhang, Lingli. "Vers la compréhension des mécanismes de réparation de l'ADN chez Streptomyces : identification d'acteurs de la recombinaison." Thesis, Université de Lorraine, 2014. http://www.theses.fr/2014LORR0104/document.

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Abstract:

Les cassures double brin de l’ADN sont des dommages pouvant engendrer la mort cellulaire. Deux mécanismes majeurs sont impliqués dans leur réparation chez les bactéries : la recombinaison homologue et le Non-Homologous End Joining (NHEJ). Streptomyces est une bactérie modèle pour étudier l'impact relatif des mécanismes de recombinaison sur la structure du génome et son évolution ; le chromosome est en effet caractérisé par sa linéarité, son organisation génétique compartimentée et sa plasticité génomique remarquable. L'objectif de cette recherche est d'identifier les acteurs impliqués dans les

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