Log in

Relevant bibliographies by topics / Homosos / Journal articles

To see the other types of publications on this topic, follow the link: Homosos.

Journal articles on the topic 'Homosos'

Author: Grafiati

Published: 24 April 2022

Last updated: 30 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Homosos.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Mizdrak, Inga. "Homososi są wśród nas czy homosos jest w nas? Próba konfrontacji myśli Aleksandra Zinowiewa i Józefa Tischnera o sytuacji człowieka w świecie." Roczniki Teologiczne 65, no. 11 (2018): 191–203. http://dx.doi.org/10.18290/rt.2018.65.11-12.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Bean, Laura E., William H. Dvorachek, Edward L. Braun, et al. "Analysis of thepdx-1(snz-1/sno-1) Region of theNeurospora crassaGenome: Correlation of Pyridoxine-Requiring Phenotypes With Mutations in Two Structural Genes." Genetics 157, no. 3 (2001): 1067–75. http://dx.doi.org/10.1093/genetics/157.3.1067.

Full text

Abstract:

AbstractWe report the analysis of a 36-kbp region of the Neurospora crassa genome, which contains homologs of two closely linked stationary phase genes, SNZ1 and SNO1, from Saccharomyces cerevisiae. Homologs of SNZ1 encode extremely highly conserved proteins that have been implicated in pyridoxine (vitamin B6) metabolism in the filamentous fungi Cercospora nicotianae and in Aspergillus nidulans. In N. crassa, SNZ and SNO homologs map to the region occupied by pdx-1 (pyridoxine requiring), a gene that has been known for several decades, but which was not sequenced previously. In this study, pyr

APA, Harvard, Vancouver, ISO, and other styles

3

Takeda, Toshiharu, Choong-Soo Yun, Masaki Shintani, Hisakazu Yamane, and Hideaki Nojiri. "Distribution of Genes Encoding Nucleoid-Associated Protein Homologs in Plasmids." International Journal of Evolutionary Biology 2011 (January 24, 2011): 1–30. http://dx.doi.org/10.4061/2011/685015.

Full text

Abstract:

Bacterial nucleoid-associated proteins (NAPs) form nucleoprotein complexes and influence the expression of genes. Recent studies have shown that some plasmids carry genes encoding NAP homologs, which play important roles in transcriptional regulation networks between plasmids and host chromosomes. In this study, we determined the distributions of the well-known NAPs Fis, H-NS, HU, IHF, and Lrp and the newly found NAPs MvaT and NdpA among the whole-sequenced 1382 plasmids found in Gram-negative bacteria. Comparisons between NAP distributions and plasmid features (size, G+C content, and putative

APA, Harvard, Vancouver, ISO, and other styles

4

Chriss, Ariana, G. Valentin Börner, and Shawn D. Ryan. "Agent-based modeling of nuclear chromosome ensemble identifies determinants of homolog pairing during meiosis." PLOS Computational Biology 20, no. 5 (2024): e1011416. http://dx.doi.org/10.1371/journal.pcbi.1011416.

Full text

Abstract:

During meiosis, pairing of homologous chromosomes (homologs) ensures the formation of haploid gametes from diploid precursor cells, a prerequisite for sexual reproduction. Pairing during meiotic prophase I facilitates crossover recombination and homolog segregation during the ensuing reductional cell division. Mechanisms that ensure stable homolog alignment in the presence of an excess of non-homologous chromosomes have remained elusive, but rapid chromosome movements during prophase I appear to play a role in the process. Apart from homolog attraction, provided by early intermediates of homol

APA, Harvard, Vancouver, ISO, and other styles

5

Noggle, F. Taylor, Jack DeRuiter, and Melinda J. Long. "Spectrophotometric and Liquid Chromatographic Identification of 3,4-Methylenedioxyphenylisopropylamine and Its N-Methyl and N-Ethyl Homologs." Journal of AOAC INTERNATIONAL 69, no. 4 (1986): 681–86. http://dx.doi.org/10.1093/jaoac/69.4.681.

Full text

Abstract:

Abstract 3,4-Methylenedioxyphenylisopropylamine (MDA) is an hallucinogenic drug that somewhat resembles lysergic acid diethylamide (LSD) in its effects. Recently, widespread abuse of the N-methyl homolog (MDMA) of MDA has led to federal control. This article reports on the synthesis of the N-ethyl homolog (MDEA) of MDA as well as spectrophotometric and chromatographic methods for identification of the 3 homologs.

APA, Harvard, Vancouver, ISO, and other styles

6

Lang, Lucas, Aladár Pettkó-Szandtner, Hasibe Tunçay Elbaşı, et al. "The DREAM complex represses growth in response to DNA damage in Arabidopsis." Life Science Alliance 4, no. 12 (2021): e202101141. http://dx.doi.org/10.26508/lsa.202101141.

Full text

Abstract:

The DNA of all organisms is constantly damaged by physiological processes and environmental conditions. Upon persistent damage, plant growth and cell proliferation are reduced. Based on previous findings that RBR1, the only Arabidopsis homolog of the mammalian tumor suppressor gene retinoblastoma, plays a key role in the DNA damage response in plants, we unravel here the network of RBR1 interactors under DNA stress conditions. This led to the identification of homologs of every DREAM component in Arabidopsis, including previously not recognized homologs of LIN52. Interestingly, we also discove

APA, Harvard, Vancouver, ISO, and other styles

7

ELAGIN, VECHESLAV A., RAYA B. ELAGINA, CHRISTOPHER J. DORO, THOMAS S. VIHTELIC, and DAVID R. HYDE. "Cloning and tissue localization of a novel zebrafish RdgB homolog that lacks a phospholipid transfer domain." Visual Neuroscience 17, no. 2 (2000): 303–11. http://dx.doi.org/10.1017/s095252380017213x.

Full text

Abstract:

The retinal degeneration B (RdgB) protein family is characterized by an amino-terminal phosphatidylinositol transfer protein (PITP) domain, several hydrophobic domains, and a highly conserved carboxyl terminus. We identified a zebrafish RdgB homolog (pl-RdgB) that lacks the amino-terminal PITP domain, while retaining over 45% amino acid identity with the two mouse RdgB proteins (M-RdgB1 and M-RdgB2). Unlike the widespread retinal expression observed for other vertebrate RdgB homologs, pl-RdgB is restricted in the retina to the cone cell inner segments. The pl-RdgB protein is also expressed in

APA, Harvard, Vancouver, ISO, and other styles

8

Ahuja, Jasvinder S., Rima Sandhu, Rana Mainpal, et al. "Control of meiotic pairing and recombination by chromosomally tethered 26S proteasome." Science 355, no. 6323 (2017): 408–11. http://dx.doi.org/10.1126/science.aaf4778.

Full text

Abstract:

During meiosis, paired homologous chromosomes (homologs) become linked via the synaptonemal complex (SC) and crossovers. Crossovers mediate homolog segregation and arise from self-inflicted double-strand breaks (DSBs). Here, we identified a role for the proteasome, the multisubunit protease that degrades proteins in the nucleus and cytoplasm, in homolog juxtaposition and crossing over. Without proteasome function, homologs failed to pair and instead remained associated with nonhomologous chromosomes. Although dispensable for noncrossover formation, a functional proteasome was required for a co

APA, Harvard, Vancouver, ISO, and other styles

9

Strickland, Kara A., Brenda Martinez Rodriguez, Ashley A. Holland, et al. "Activity assays of NnlA homologs suggest the natural product N-nitroglycine is degraded by diverse bacteria." Beilstein Journal of Organic Chemistry 20 (April 17, 2024): 830–40. http://dx.doi.org/10.3762/bjoc.20.75.

Full text

Abstract:

Linear nitramines (R–N(R′)NO2; R′ = H or alkyl) are toxic compounds, some with environmental relevance, while others are rare natural product nitramines. One of these natural product nitramines is N-nitroglycine (NNG), which is produced by some Streptomyces strains and exhibits antibiotic activity towards Gram-negative bacteria. An NNG degrading heme enzyme, called NnlA, has recently been discovered in the genome of Variovorax sp. strain JS1663 (Vs NnlA). Evidence is presented that NnlA and therefore, NNG degradation activity is widespread. To achieve this objective, we characterized and teste

APA, Harvard, Vancouver, ISO, and other styles

10

Stafford, Kate A., and Arthur G. Palmer III. "Evidence from molecular dynamics simulations of conformational preorganization in the ribonuclease H active site." F1000Research 3 (March 7, 2014): 67. http://dx.doi.org/10.12688/f1000research.3605.1.

Full text

Abstract:

Ribonuclease H1 (RNase H) enzymes are well-conserved endonucleases that are present in all domains of life and are particularly important in the life cycle of retroviruses as domains within reverse transcriptase. Despite extensive study, especially of the E. coli homolog, the interaction of the highly negatively charged active site with catalytically required magnesium ions remains poorly understood. In this work, we describe molecular dynamics simulations of the E. coli homolog in complex with magnesium ions, as well as simulations of other homologs in their apo states. Collectively, these re

APA, Harvard, Vancouver, ISO, and other styles

11

Mendillo, Marc L., Victoria V. Hargreaves, Jonathan W. Jamison, et al. "A conserved MutS homolog connector domain interface interacts with MutL homologs." Proceedings of the National Academy of Sciences 106, no. 52 (2009): 22223–28. http://dx.doi.org/10.1073/pnas.0912250106.

Full text

APA, Harvard, Vancouver, ISO, and other styles

12

Laidlaw, Stephen M., M. Arif Anwar, Warren Thomas, Philip Green, Kathy Shaw, and Michael A. Skinner. "Fowlpox Virus Encodes Nonessential Homologs of Cellular Alpha-SNAP, PC-1, and an Orphan Human Homolog of a Secreted Nematode Protein." Journal of Virology 72, no. 8 (1998): 6742–51. http://dx.doi.org/10.1128/jvi.72.8.6742-6751.1998.

Full text

Abstract:

ABSTRACT The genome of fowlpox virus (FWPV), type species of theAvipoxviridae, is considerably rearranged compared with that of vaccinia virus (the prototypic poxvirus and type species of theOrthopoxviridae) and is 30% larger. It is likely that the genome of FWPV contains genes in addition to those found in vaccinia virus, probably involved with its replication and survival in the chicken. A 7,470-bp segment of the FWPV genome has five open reading frames (ORFs), two of which encode ankyrin repeat proteins, many examples of which have been found in poxviruses. The remaining ORFs encode homolog

APA, Harvard, Vancouver, ISO, and other styles

13

Moomaw, Andrea S., and Michael E. Maguire. "The Unique Nature of Mg2+ Channels." Physiology 23, no. 5 (2008): 275–85. http://dx.doi.org/10.1152/physiol.00019.2008.

Full text

Abstract:

Considering the biological abundance and importance of Mg2+, there is a surprising lack of information regarding the proteins that transport Mg2+, the mechanisms by which they do so, and their physiological roles within the cell. The best characterized Mg2+ channel to date is the bacterial protein CorA, present in a wide range of bacterial species. The CorA homolog Mrs2 forms the mitochondrial Mg2+ channel in all eukaryotes. Physiologically, CorA is involved in bacterial pathogenesis, and the Mrs2 eukaryotic homolog is essential for cell survival. A second Mg2+ channel widespread in bacteria i

APA, Harvard, Vancouver, ISO, and other styles

14

Rose, Timothy M., Jonathan T. Ryan, Emily R. Schultz, Brian W. Raden, and Che-Chung Tsai. "Analysis of 4.3 Kilobases of Divergent Locus B of Macaque Retroperitoneal Fibromatosis-Associated Herpesvirus Reveals a Close Similarity in Gene Sequence and Genome Organization to Kaposi's Sarcoma-Associated Herpesvirus." Journal of Virology 77, no. 9 (2003): 5084–97. http://dx.doi.org/10.1128/jvi.77.9.5084-5097.2003.

Full text

Abstract:

ABSTRACT We previously identified retroperitoneal fibromatosis-associated herpesvirus (RFHV) as a simian homolog of Kaposi's sarcoma-associated herpesvirus (KSHV) in a fibroproliferative malignancy of macaques that has similarities to Kaposi's sarcoma. In this report, we cloned 4.3 kb of divergent locus B (DL-B) flanking the DNA polymerase gene from two variants of RFHV from different species of macaque with a consensus degenerate hybrid oligonucleotide primer approach. Within the DL-B region of RFHV, viral homologs of the cellular interleukin-6, dihydrofolate reductase, and thymidylate syntha

APA, Harvard, Vancouver, ISO, and other styles

15

Park, Na Yeon, Doo Sin Jo, and Dong-Hyung Cho. "Post-Translational Modifications of ATG4B in the Regulation of Autophagy." Cells 11, no. 8 (2022): 1330. http://dx.doi.org/10.3390/cells11081330.

Full text

Abstract:

Autophagy plays a key role in eliminating and recycling cellular components in response to stress, including starvation. Dysregulation of autophagy is observed in various diseases, including neurodegenerative diseases, cancer, and diabetes. Autophagy is tightly regulated by autophagy-related (ATG) proteins. Autophagy-related 4 (ATG4) is the sole cysteine protease, and four homologs (ATG4A–D) have been identified in mammals. These proteins have two domains: catalytic and short fingers. ATG4 facilitates autophagy by promoting autophagosome maturation through reversible lipidation and delipidatio

APA, Harvard, Vancouver, ISO, and other styles

16

Lehner, C. F., and P. H. O'Farrell. "Drosophila cdc2 homologs: a functional homolog is coexpressed with a cognate variant." EMBO Journal 9, no. 11 (1990): 3573–81. http://dx.doi.org/10.1002/j.1460-2075.1990.tb07568.x.

Full text

APA, Harvard, Vancouver, ISO, and other styles

17

Barbosa, Gisele, Luis Gabriel Valdivieso Gelves, Caroline Marques Xavier Costa, et al. "Discovery of Putative Dual Inhibitor of Tubulin and EGFR by Phenotypic Approach on LASSBio-1586 Homologs." Pharmaceuticals 15, no. 8 (2022): 913. http://dx.doi.org/10.3390/ph15080913.

Full text

Abstract:

Combretastatin A-4 (CA-4, 1) is an antimicrotubule agent used as a prototype for the design of several synthetic analogues with anti-tubulin activity, such as LASSBio-1586 (2). A series of branched and unbranched homologs of the lead-compound 2, and vinyl, ethinyl and benzyl analogues, were designed and synthesized. A comparison between the cytotoxic effect of these homologs and 2 on different human tumor cell lines was performed from a cell viability study using MTT with 48 h and 72 h incubations. In general, the compounds were less potent than CA-4, showing CC50 values ranging from 0.030 μM

APA, Harvard, Vancouver, ISO, and other styles

18

Stakheev, A. A., R. R. Kutukov, M. E. Taliansky, and Sergey Kiriakovich Zavriev. "Investigating the Structure of the Components of the PolyADP-Ribosylation System in Fusarium Fungi and Evaluating the Expression Dynamics of Its Key Genes." Acta Naturae 16, no. 3 (2024): 83–92. http://dx.doi.org/10.32607/actanaturae.27450.

Full text

Abstract:

Poly(ADP-ribose) polymerase (PARP) is the key enzyme in polyADP-ribosylation, one of the main post-translational modifications. This enzyme is abundant in eukaryotic organisms. However, information on the PARP structure and its functions in members of the Fungi kingdom is very limited. In this study, we performed a bioinformatic search for homologs of PARP and its antagonist, PARG, in the genomes of four Fusarium strains using their whole-genome sequences annotated and deposited in databases. The F. graminearum PH-1, F. proliferatum ET-1, and F. oxysporum Fo47 strains were shown to possess a s

APA, Harvard, Vancouver, ISO, and other styles

19

Ueda, Ohmi, Hannah M. Wexler, Kaname Hirai, Yukinaga Shibata, Fuminobu Yoshimura, and Setsuo Fujimura. "Sixteen Homologs of the Mex-Type Multidrug Resistance Efflux Pump in Bacteroides fragilis." Antimicrobial Agents and Chemotherapy 49, no. 7 (2005): 2807–15. http://dx.doi.org/10.1128/aac.49.7.2807-2815.2005.

Full text

Abstract:

ABSTRACT Sixteen homologs of multidrug resistance efflux pump operons of the resistance-nodulation-cell division (RND) family were found in the Bacteroides fragilis genome sequence by homology searches. Disruption mutants were made to the mexB homologs of the four genes most similar to Pseudomonas aeruginosa mexB. Reverse transcription-PCR was conducted and indicated that the genes were transcribed in a polycistronic fashion and that the promoter was upstream of bmeA (the mexA homolog). One of these disruption mutants (in bmeB, the mexB homolog) was more susceptible than the parental strain to

APA, Harvard, Vancouver, ISO, and other styles

20

McLenigan, Mary P., Olga I. Kulaeva, Don G. Ennis, Arthur S. Levine, and Roger Woodgate. "The Bacteriophage P1 HumD Protein Is a Functional Homolog of the Prokaryotic UmuD′-Like Proteins and Facilitates SOS Mutagenesis in Escherichia coli." Journal of Bacteriology 181, no. 22 (1999): 7005–13. http://dx.doi.org/10.1128/jb.181.22.7005-7013.1999.

Full text

Abstract:

ABSTRACT The Escherichia coli umuD and umuC genes comprise an operon and encode proteins that are involved in the mutagenic bypass of normally replication-inhibiting DNA lesions. UmuD is, however, unable to function in this process until it undergoes a RecA-mediated cleavage reaction to generate UmuD′. Many homologs ofumuDC have now been identified. Most are located on bacterial chromosomes or on broad-host-range R plasmids. One such putative homolog, humD (homolog of umuD) is, however, found on the bacteriophage P1 genome. Interestingly,humD differs from other umuD homologs in that it encodes

APA, Harvard, Vancouver, ISO, and other styles

21

Serwer, Philip. "Optimizing Anti-Viral Vaccine Responses: Input from a Non-Specialist." Antibiotics 9, no. 5 (2020): 255. http://dx.doi.org/10.3390/antibiotics9050255.

Full text

Abstract:

Recently, the research community has had a real-world look at reasons for improving vaccine responses to emerging RNA viruses. Here, a vaccine non-specialist suggests how this might be done. I propose two alternative options and compare the primary alternative option with current practice. The basis of comparison is feasibility in achieving what we need: a safe, mass-produced, emerging virus-targeted vaccine on 2–4 week notice. The primary option is the following. (1) Start with a platform based on live viruses that infect bacteria, but not humans (bacteriophages, or phages). (2) Isolate phage

APA, Harvard, Vancouver, ISO, and other styles

22

Sewalt, Richard G. A. B., Marco J. Gunster, Johan van der Vlag, David P. E. Satijn, and Arie P. Otte. "C-Terminal Binding Protein Is a Transcriptional Repressor That Interacts with a Specific Class of Vertebrate Polycomb Proteins." Molecular and Cellular Biology 19, no. 1 (1999): 777–87. http://dx.doi.org/10.1128/mcb.19.1.777.

Full text

Abstract:

ABSTRACT Polycomb (Pc) is part of a Pc group (PcG) protein complex that is involved in repression of gene activity during Drosophilaand vertebrate development. To identify proteins that interact with vertebrate Pc homologs, we performed two-hybrid screens withXenopus Pc (XPc) and human Pc 2 (HPC2). We find that the C-terminal binding protein (CtBP) interacts with XPc and HPC2, that CtBP and HPC2 coimmunoprecipitate, and that CtBP and HPC2 partially colocalize in large PcG domains in interphase nuclei. CtBP is a protein with unknown function that binds to a conserved 6-amino-acid motif in the C

APA, Harvard, Vancouver, ISO, and other styles

23

Lomax, Jo E., Chelcie H. Eller, and Ronald T. Raines. "Comparative functional analysis of ribonuclease 1 homologs: molecular insights into evolving vertebrate physiology." Biochemical Journal 474, no. 13 (2017): 2219–33. http://dx.doi.org/10.1042/bcj20170173.

Full text

Abstract:

Pancreatic-type ribonucleases (ptRNases) comprise a class of highly conserved secretory endoribonucleases in vertebrates. The prototype of this enzyme family is ribonuclease 1 (RNase 1). Understanding the physiological roles of RNase 1 is becoming increasingly important, as engineered forms of the enzyme progress through clinical trials as chemotherapeutic agents for cancer. Here, we present an in-depth biochemical characterization of RNase 1 homologs from a broad range of mammals (human, bat, squirrel, horse, cat, mouse, and cow) and nonmammalian species (chicken, lizard, and frog). We discov

APA, Harvard, Vancouver, ISO, and other styles

24

Marshall, William L., Ching Yim, Erik Gustafson, et al. "Epstein-Barr Virus Encodes a Novel Homolog of the bcl-2 Oncogene That Inhibits Apoptosis and Associates with Bax and Bak." Journal of Virology 73, no. 6 (1999): 5181–85. http://dx.doi.org/10.1128/jvi.73.6.5181-5185.1999.

Full text

Abstract:

ABSTRACT The sequenced gammaherpesviruses each contain a single viralbcl-2 homolog (v-bcl-2) which may encode a protein that functions in preventing the apoptotic death of virus-infected cells. Epstein-Barr virus (EBV), a gammaherpesvirus associated with several lymphoid and epithelial malignancies, encodes the v-Bcl-2 homolog BHRF1. In this report the previously uncharacterized BALF1 open reading frame in EBV is identified as having significant sequence similarity to other v-bcl-2 homologs and cellular bcl-2. Transfection of cells with a BALF1 cDNA conferred apoptosis resistance. Furthermore,

APA, Harvard, Vancouver, ISO, and other styles

25

Wu, C. T., M. Budding, M. S. Griffin, and J. M. Croop. "Isolation and characterization of Drosophila multidrug resistance gene homologs." Molecular and Cellular Biology 11, no. 8 (1991): 3940–48. http://dx.doi.org/10.1128/mcb.11.8.3940-3948.1991.

Full text

Abstract:

Mammalian multidrug-resistant cell lines, selected for resistance to a single cytotoxic agent, display cross-resistance to a broad spectrum of structurally and functionally unrelated compounds. These cell lines overproduce a membrane protein, the P-glycoprotein, which is encoded by a member(s) of a multigene family, termed mdr or pgp. The amino acid sequence of the P-glycoprotein predicts an energy-dependent transport protein with homology to a large superfamily of proteins which transport a wide variety of substances. This report describes the isolation and characterization of two Drosophila

APA, Harvard, Vancouver, ISO, and other styles

26

Wu, C. T., M. Budding, M. S. Griffin, and J. M. Croop. "Isolation and characterization of Drosophila multidrug resistance gene homologs." Molecular and Cellular Biology 11, no. 8 (1991): 3940–48. http://dx.doi.org/10.1128/mcb.11.8.3940.

Full text

Abstract:

Mammalian multidrug-resistant cell lines, selected for resistance to a single cytotoxic agent, display cross-resistance to a broad spectrum of structurally and functionally unrelated compounds. These cell lines overproduce a membrane protein, the P-glycoprotein, which is encoded by a member(s) of a multigene family, termed mdr or pgp. The amino acid sequence of the P-glycoprotein predicts an energy-dependent transport protein with homology to a large superfamily of proteins which transport a wide variety of substances. This report describes the isolation and characterization of two Drosophila

APA, Harvard, Vancouver, ISO, and other styles

27

Davis, Luther, and Gerald R. Smith. "Nonrandom Homolog Segregation at Meiosis I in Schizosaccharomyces pombe Mutants Lacking Recombination." Genetics 163, no. 3 (2003): 857–74. http://dx.doi.org/10.1093/genetics/163.3.857.

Full text

Abstract:

Abstract Physical connection between homologous chromosomes is normally required for their proper segregation to opposite poles at the first meiotic division (MI). This connection is generally provided by the combination of reciprocal recombination and sister-chromatid cohesion. In the absence of meiotic recombination, homologs are predicted to segregate randomly at MI. Here we demonstrate that in rec12 mutants of the fission yeast Schizosaccharomyces pombe, which are devoid of meiosis-induced recombination, homologs segregate to opposite poles at MI 63% of the time. Residual, Rec12-independen

APA, Harvard, Vancouver, ISO, and other styles

28

Quiros, C. F., F. Grellet, J. Sadowski, T. Suzuki, G. Li, and T. Wroblewski. "Arabidopsis and Brassica Comparative Genomics: Sequence, Structure and Gene Content in the ABI1-Rps2-Ck1 Chromosomal Segment and Related Regions." Genetics 157, no. 3 (2001): 1321–30. http://dx.doi.org/10.1093/genetics/157.3.1321.

Full text

Abstract:

Abstract The region corresponding to the ABI1-Rps2-Ck1 segment on chromosome 4 of Arabidopsis thaliana was sequenced in Brassica oleracea. Similar to A. thaliana, the B. oleracea homolog BoRps2 is present in single copy. The B. oleracea orthologous segment was located on chromosome 4 and can be distinguished by the presence of an N-myristoyl transferase coding gene (N-myr) between the Rps2 and Ck1 (BoCk1a) genes. The N-myr homologs in Arabidopsis are on chromosomes 2 and 5. Additional homologs for Ck1 are located on these two chromosomes. A second Ck1 homolog found on B. oleracea (BoCk1b) chro

APA, Harvard, Vancouver, ISO, and other styles

29

Liao, Lisheng, Amy L. Schaefer, Bruna G. Coutinho, Pamela J. B. Brown, and E. Peter Greenberg. "An aryl-homoserine lactone quorum-sensing signal produced by a dimorphic prosthecate bacterium." Proceedings of the National Academy of Sciences 115, no. 29 (2018): 7587–92. http://dx.doi.org/10.1073/pnas.1808351115.

Full text

Abstract:

Many species ofProteobacteriaproduce acyl-homoserine lactone (AHL) compounds as quorum-sensing (QS) signals for cell density-dependent gene regulation. Most known AHL synthases, LuxI-type enzymes, produce fatty AHLs, and the fatty acid moiety is derived from an acyl-acyl carrier protein (ACP) intermediate in fatty acid biosynthesis. Recently, a class of LuxI homologs has been shown to use CoA-linked aromatic or amino acid substrates for AHL synthesis. By using an informatics approach, we found the CoA class of LuxI homologs exists primarily in α-Proteobacteria. The genome ofProsthecomicrobium

APA, Harvard, Vancouver, ISO, and other styles

30

Lin, Nai-Chun, Robert B. Abramovitch, Young Jin Kim, and Gregory B. Martin. "Diverse AvrPtoB Homologs from Several Pseudomonas syringae Pathovars Elicit Pto-Dependent Resistance and Have Similar Virulence Activities." Applied and Environmental Microbiology 72, no. 1 (2006): 702–12. http://dx.doi.org/10.1128/aem.72.1.702-712.2006.

Full text

Abstract:

ABSTRACT AvrPtoB is a type III effector protein from Pseudomonas syringae pv. tomato that physically interacts with the tomato Pto kinase and, depending on the host genotype, either elicits or suppresses programmed cell death associated with plant immunity. We reported previously that avrPtoB-related sequences are present in diverse gram-negative phytopathogenic bacteria. Here we describe characterization of avrPtoB homologs from P. syringae pv. tomato T1, PT23, and JL1065, P. syringae pv. syringae B728a, and P. syringae pv. maculicola ES4326. The avrPtoB homolog from P. syringae pv. maculicol

APA, Harvard, Vancouver, ISO, and other styles

31

Jun, Hye-Kyoung, Young-Mi Kang, Hae-Ri Lee, Sung-Hoon Lee, and Bong-Kyu Choi. "Highly Conserved Surface Proteins of Oral Spirochetes as Adhesins and Potent Inducers of Proinflammatory and Osteoclastogenic Factors." Infection and Immunity 76, no. 6 (2008): 2428–38. http://dx.doi.org/10.1128/iai.01128-07.

Full text

Abstract:

ABSTRACT Oral spirochetes include enormously heterogeneous Treponema species, and some have been implicated in the etiology of periodontitis. In this study, we characterized highly conserved surface proteins in four representative oral spirochetes (Treponema denticola, T. lecithinolyticum, T. maltophilum, and T. socranskii subsp. socranskii) that are homologs of T. pallidum Tp92, with opsonophagocytic potential and protective capacity against syphilis. Tp92 homologs of oral spirochetes had predicted signal peptides (20 to 31 amino acids) and molecular masses of 88 to 92 kDa for mature proteins

APA, Harvard, Vancouver, ISO, and other styles

32

Zhao, Tong, Francisco Cruz, and James G. Ferry. "Iron-Sulfur Flavoprotein (Isf) fromMethanosarcina thermophila Is the Prototype of a Widely Distributed Family." Journal of Bacteriology 183, no. 21 (2001): 6225–33. http://dx.doi.org/10.1128/jb.183.21.6225-6233.2001.

Full text

Abstract:

ABSTRACT A total of 35 homologs of the iron-sulfur flavoprotein (Isf) fromMethanosarcina thermophila were identified in databases. All three domains were represented, and multiple homologs were present in several species. An unusually compact cysteine motif ligating the 4Fe-4S cluster in Isf is conserved in all of the homologs except two, in which either an aspartate or a histidine has replaced the second cysteine in the motif. A phylogenetic analysis of Isf homologs identified four subgroups, two of which were supported by bootstrap data. Three homologs from metabolically and phylogenetically

APA, Harvard, Vancouver, ISO, and other styles

33

Pizzo, Lucilla, Micaela Lasser, Tanzeen Yusuff, et al. "Functional assessment of the “two-hit” model for neurodevelopmental defects in Drosophila and X. laevis." PLOS Genetics 17, no. 4 (2021): e1009112. http://dx.doi.org/10.1371/journal.pgen.1009112.

Full text

Abstract:

We previously identified a deletion on chromosome 16p12.1 that is mostly inherited and associated with multiple neurodevelopmental outcomes, where severely affected probands carried an excess of rare pathogenic variants compared to mildly affected carrier parents. We hypothesized that the 16p12.1 deletion sensitizes the genome for disease, while “second-hits” in the genetic background modulate the phenotypic trajectory. To test this model, we examined how neurodevelopmental defects conferred by knockdown of individual 16p12.1 homologs are modulated by simultaneous knockdown of homologs of “sec

APA, Harvard, Vancouver, ISO, and other styles

34

Wommack, K. Eric, Jaysheel Bhavsar, and Jacques Ravel. "Metagenomics: Read Length Matters." Applied and Environmental Microbiology 74, no. 5 (2008): 1453–63. http://dx.doi.org/10.1128/aem.02181-07.

Full text

Abstract:

ABSTRACT Obtaining an unbiased view of the phylogenetic composition and functional diversity within a microbial community is one central objective of metagenomic analysis. New technologies, such as 454 pyrosequencing, have dramatically reduced sequencing costs, to a level where metagenomic analysis may become a viable alternative to more-focused assessments of the phylogenetic (e.g., 16S rRNA genes) and functional diversity of microbial communities. To determine whether the short (∼100 to 200 bp) sequence reads obtained from pyrosequencing are appropriate for the phylogenetic and functional ch

APA, Harvard, Vancouver, ISO, and other styles

35

Reenan, R. A., and R. D. Kolodner. "Isolation and characterization of two Saccharomyces cerevisiae genes encoding homologs of the bacterial HexA and MutS mismatch repair proteins." Genetics 132, no. 4 (1992): 963–73. http://dx.doi.org/10.1093/genetics/132.4.963.

Full text

Abstract:

Abstract Homologs of the Escherichia coli (mutL, S and uvrD) and Streptococcus pneumoniae (hexA, B) genes involved in mismatch repair are known in several distantly related organisms. Degenerate oligonucleotide primers based on conserved regions of E. coli MutS protein and its homologs from Salmonella typhimurium, S. pneumoniae and human were used in the polymerase chain reaction (PCR) to amplify and clone mutS/hexA homologs from Saccharomyces cerevisiae. Two DNA sequences were amplified whose deduced amino acid sequences both shared a high degree of homology with MutS. These sequences were th

APA, Harvard, Vancouver, ISO, and other styles

36

Novik, Veronica, Dirk Hofreuter, and Jorge E. Galán. "Characterization of a Campylobacter jejuni VirK Protein Homolog as a Novel Virulence Determinant." Infection and Immunity 77, no. 12 (2009): 5428–36. http://dx.doi.org/10.1128/iai.00528-09.

Full text

Abstract:

ABSTRACT Campylobacter jejuni is a leading cause of food-borne illness in the United States. Despite significant recent advances, its mechanisms of pathogenesis are poorly understood. A unique feature of this pathogen is that, with some exceptions, it lacks homologs of known virulence factors from other pathogens. Through a genetic screen, we have identified a C. jejuni homolog of the VirK family of virulence factors, which is essential for antimicrobial peptide resistance and mouse virulence.

APA, Harvard, Vancouver, ISO, and other styles

37

Segel, Michael, Blake Lash, Jingwei Song, et al. "Mammalian retrovirus-like protein PEG10 packages its own mRNA and can be pseudotyped for mRNA delivery." Science 373, no. 6557 (2021): 882–89. http://dx.doi.org/10.1126/science.abg6155.

Full text

Abstract:

Eukaryotic genomes contain domesticated genes from integrating viruses and mobile genetic elements. Among these are homologs of the capsid protein (known as Gag) of long terminal repeat (LTR) retrotransposons and retroviruses. We identified several mammalian Gag homologs that form virus-like particles and one LTR retrotransposon homolog, PEG10, that preferentially binds and facilitates vesicular secretion of its own messenger RNA (mRNA). We showed that the mRNA cargo of PEG10 can be reprogrammed by flanking genes of interest with Peg10’s untranslated regions. Taking advantage of this reprogram

APA, Harvard, Vancouver, ISO, and other styles

38

Hinch, Anjali Gupta, Gang Zhang, Philipp W. Becker, et al. "Factors influencing meiotic recombination revealed by whole-genome sequencing of single sperm." Science 363, no. 6433 (2019): eaau8861. http://dx.doi.org/10.1126/science.aau8861.

Full text

Abstract:

Recombination is critical to meiosis and evolution, yet many aspects of the physical exchange of DNA via crossovers remain poorly understood. We report an approach for single-cell whole-genome DNA sequencing by which we sequenced 217 individual hybrid mouse sperm, providing a kilobase-resolution genome-wide map of crossovers. Combining this map with molecular assays measuring stages of recombination, we identified factors that affect crossover probability, including PRDM9 binding on the non-initiating template homolog and telomere proximity. These factors also influence the time for sites of r

APA, Harvard, Vancouver, ISO, and other styles

39

Sharma, Amit, and Deepak T. Nair. "MsDpo4—a DinB Homolog fromMycobacterium smegmatis—Is an Error-Prone DNA Polymerase That Can Promote G:T and T:G Mismatches." Journal of Nucleic Acids 2012 (2012): 1–8. http://dx.doi.org/10.1155/2012/285481.

Full text

Abstract:

Error-prone DNA synthesis in prokaryotes imparts plasticity to the genome to allow for evolution in unfavorable environmental conditions, and this phenomenon is termed adaptive mutagenesis. At a molecular level, adaptive mutagenesis is mediated by upregulating the expression of specialized error-prone DNA polymerases that generally belong to the Y-family, such as the polypeptide product of thedinBgene in case ofE. coli. However, unlikeE. coli, it has been seen that expression of the homologs ofdinBinMycobacterium tuberculosisare not upregulated under conditions of stress. These studies suggest

APA, Harvard, Vancouver, ISO, and other styles

40

Verma, Divya. "PROTEIN KINASES AS DRUG TARGET AGAINST TRYPANOSOMA BRUCEI." Journal of Advanced Scientific Research 14, no. 04 (2023): 1–8. http://dx.doi.org/10.55218/jasr.202314402.

Full text

Abstract:

Protein kinases are the most studied proteins as drug targets against deadly disease ‘sleeping sickness. The crystal structures for the Trypanosoma brucei protein kinase A catalytic subunit isoform 1 (PKAC1) and cell division-related protein kinase 2 (CDK2) are still not known. Therefore, homology models were constructed for the two proteins, based on their known amino acid sequences. The catalytic sites of both the proteins were then compared with their respective human homologs. Except for some conformational differences, the active site of TbrPKAC1 was found to be quite similar to that of t

APA, Harvard, Vancouver, ISO, and other styles

41

Liebe, Bodo, Manfred Alsheimer, Christer Höög, Ricardo Benavente, and Harry Scherthan. "Telomere Attachment, Meiotic Chromosome Condensation, Pairing, and Bouquet Stage Duration Are Modified in Spermatocytes Lacking Axial Elements." Molecular Biology of the Cell 15, no. 2 (2004): 827–37. http://dx.doi.org/10.1091/mbc.e03-07-0524.

Full text

Abstract:

During the extended prophase to the meiosis I division, chromosomes assemble axial elements (AE) along replicated sister chromatids whose ends attach to the inner nuclear membrane (NM) via a specialized conical thickening. Here, we show at the EM level that in Sycp3-/- spermatocyte chromosomes lack the AE and the conical end thickening, but still they attach their telomeres to the inner NM with an electron-dense plate that contains T2AG3 repeats. Immunofluorescence detected telomere proteins, SCP2, and the meiosis-specific cohesin STAG3 at the Sycp3-/- telomere. Bouquet stage spermatocytes wer

APA, Harvard, Vancouver, ISO, and other styles

42

Nagele, R. G., T. Freeman, L. McMorrow, Z. Thomson, K. Kitson-Wind, and Hy Lee. "Chromosomes exhibit preferential positioning in nuclei of quiescent human cells." Journal of Cell Science 112, no. 4 (1999): 525–35. http://dx.doi.org/10.1242/jcs.112.4.525.

Full text

Abstract:

The relative spatial positioning of chromosomes 7, 8, 16, X and Y was examined in nuclei of quiescent (noncycling) diploid and triploid human fibroblasts using fluorescence in situ hybridization (FISH) with chromosome-specific DNA probes and digital imaging. In quiescent diploid cells, interhomolog distances and chromosome homolog position maps revealed a nonrandom, preferential topology for chromosomes 7, 8 and 16, whereas chromosome X approximated a more random distribution. Variations in the orientation of nuclei on the culture substratum tended to hinder detection of an ordered chromosome

APA, Harvard, Vancouver, ISO, and other styles

43

Wang, Fei, Zhihui Zheng, Ye Yuan, Jianguo Li, and Minglei Zhao. "Identification and Characterization of HAESA-Like Genes Involved in the Fruitlet Abscission in Litchi." International Journal of Molecular Sciences 20, no. 23 (2019): 5945. http://dx.doi.org/10.3390/ijms20235945.

Full text

Abstract:

Regulation of abscission is an important agricultural concern since precocious abscission can reduce crop yield. INFLORESCENCE DEFICIENT IN ABSCISSION (IDA) peptide and its receptors the HAESA (HAE) and HAESA-like2 (HSL2) kinases have been revealed to be core components controlling floral organ abscission in the model plant Arabidopsis. However, it is still unclear whether the homologs of IDA-HAE/HSL2 in non-model plants are correlated to abscission. Previously, we found LcIDL1, a homolog of IDA from litchi, has a similar role to AtIDA in control of floral organ abscission in Arabidopsis. Here

APA, Harvard, Vancouver, ISO, and other styles

44

Villeneuve, A. M. "A cis-acting locus that promotes crossing over between X chromosomes in Caenorhabditis elegans." Genetics 136, no. 3 (1994): 887–902. http://dx.doi.org/10.1093/genetics/136.3.887.

Full text

Abstract:

Abstract This study reports the characterization of a cis-acting locus on the Caenorhabditis elegans X chromosome that is crucial for promoting normal levels of crossing over specifically between the X homologs and for ensuring their proper disjunction at meiosis I. The function of this locus is disrupted by the mutation me8, which maps to the extreme left end of the X chromosome within the region previously implicated by studies of X; A translocations and X duplications to contain a meiotic pairing site. Hermaphrodites homozygous for a deletion of the locus (Df/Df) or heterozygous for a delet

APA, Harvard, Vancouver, ISO, and other styles

45

Kabakci, Zeynep, Hiro Yamada, Luisa Vernizzi, et al. "Teflon promotes chromosomal recruitment of homolog conjunction proteins during Drosophila male meiosis." PLOS Genetics 18, no. 10 (2022): e1010469. http://dx.doi.org/10.1371/journal.pgen.1010469.

Full text

Abstract:

Meiosis in males of higher dipterans is achiasmate. In their spermatocytes, pairing of homologs into bivalent chromosomes does not include synaptonemal complex and crossover formation. While crossovers preserve homolog conjunction until anaphase I during canonical meiosis, an alternative system is used in dipteran males. Mutant screening in Drosophila melanogaster has identified teflon (tef) as being required specifically for alternative homolog conjunction (AHC) of autosomal bivalents. The additional known AHC genes, snm, uno and mnm, are needed for the conjunction of autosomal homologs and o

APA, Harvard, Vancouver, ISO, and other styles

46

Anand, Swadha, Bhusan K. Kuntal, Anwesha Mohapatra, Vineet Bhatt, and Sharmila S. Mande. "FunGeCo: a web-based tool for estimation of functional potential of bacterial genomes and microbiomes using gene context information." Bioinformatics 36, no. 8 (2019): 2575–77. http://dx.doi.org/10.1093/bioinformatics/btz957.

Full text

Abstract:

Abstract Motivation Functional potential of genomes and metagenomes which are inferred using homology-based methods are often subjected to certain limitations, especially for proteins with homologs which function in multiple pathways. Augmenting the homology information with genomic location of the constituent genes can significantly improve the accuracy of estimated functions. This can help in distinguishing cognate homolog belonging to a candidate pathway from its other homologs functional in different pathways. Results In this article, we present a web-based analysis platform ‘FunGeCo’ to e

APA, Harvard, Vancouver, ISO, and other styles

47

Zarnowski, Robert, and Arkadiusz Kozubek. "Alkylresorcinol Homologs in Pisum sativum L. Varieties." Zeitschrift für Naturforschung C 54, no. 1-2 (1999): 44–48. http://dx.doi.org/10.1515/znc-1999-1-208.

Full text

Abstract:

Acetone extracts from the seeds of Pisum sativum L. sensu lato (Leguminoseae) separated by thin layer chromatography revealed the occurrence of hands with chromatographic mobility and color reaction with Fast Blue B characteristic for 1,3-dihydroxy-5-alkyIbenzenes. These polyketide metabolites have been isolated and identified by Spectroscopic means. The occurrence of homologous series of saturated (approximately 70%) and enoic (mono and diunsaturated) homologs with chain length of C15 to C25 has been revealed with C17 as the main homolog

APA, Harvard, Vancouver, ISO, and other styles

48

Vernizzi, Luisa, and Christian F. Lehner. "Dispersive forces and resisting spot welds by alternative homolog conjunction govern chromosome shape in Drosophila spermatocytes during prophase I." PLOS Genetics 18, no. 7 (2022): e1010327. http://dx.doi.org/10.1371/journal.pgen.1010327.

Full text

Abstract:

The bivalent chromosomes that are generated during prophase of meiosis I comprise a pair of homologous chromosomes. Homolog pairing during prophase I must include mechanisms that avoid or eliminate entanglements between non-homologous chromosomes. In Drosophila spermatocytes, non-homologous associations are disrupted by chromosome territory formation, while linkages between homologous chromosomes are maintained by special conjunction proteins. These proteins function as alternative for crossovers that link homologs during canonical meiosis but are absent during the achiasmate Drosophila male m

APA, Harvard, Vancouver, ISO, and other styles

49

Lilay, Grmay H., Pedro Humberto Castro, Joana G. Guedes, et al. "Rice F-bZIP transcription factors regulate the zinc deficiency response." Journal of Experimental Botany 71, no. 12 (2020): 3664–77. http://dx.doi.org/10.1093/jxb/eraa115.

Full text

Abstract:

Abstract The F-bZIP transcription factors bZIP19 and bZIP23 are the central regulators of the zinc deficiency response in Arabidopsis, and phylogenetic analysis of F-bZIP homologs across land plants indicates that the regulatory mechanism of the zinc deficiency response may be conserved. Here, we identified the rice F-bZIP homologs and investigated their function. OsbZIP48 and OsbZIP50, but not OsbZIP49, complement the zinc deficiency-hypersensitive Arabidopsis bzip19bzip23 double mutant. Ectopic expression of OsbZIP50 in Arabidopsis significantly increases plant zinc accumulation under contro

APA, Harvard, Vancouver, ISO, and other styles

50

Harms, Jerome S., Xiaodi Ren, Sergio C. Oliveira, and Gary A. Splitter. "Distinctions between Bovine Herpesvirus 1 and Herpes Simplex Virus Type 1 VP22 Tegument Protein Subcellular Associations." Journal of Virology 74, no. 7 (2000): 3301–12. http://dx.doi.org/10.1128/jvi.74.7.3301-3312.2000.

Full text

Abstract:

ABSTRACT The alphaherpesvirus tegument protein VP22 has been characterized with multiple traits including microtubule reorganization, nuclear localization, and nonclassical intercellular trafficking. However, all these data were derived from studies using herpes simplex virus type 1 (HSV-1) and may not apply to VP22 homologs of other alphaherpesviruses. We compared subcellular attributes of HSV-1 VP22 (HVP22) with bovine herpesvirus 1 (BHV-1) VP22 (BVP22) using green fluorescent protein (GFP)-fused VP22 expression vectors. Fluorescence microscopy of cell lines transfected with these constructs

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!