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Dissertations / Theses on the topic 'Hormones, Sex – Receptors'

Author: Grafiati

Published: 4 June 2021

Last updated: 9 February 2022

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1

ElBaradie, Khairat Bahgat. "Membrane effects of sex hormones on growth plate chondrocytes." Diss., Georgia Institute of Technology, 2012. http://hdl.handle.net/1853/45956.

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Understanding and studying the normal bone growth and development is causal. Bone and cartilage tissue provide in addition to their mechanical support, they provide a protection for vital organs such as heart, lung and brain. Longitudinal growth is regulated by the activity of chondrocytes in the epiphyseal growth plates of long bones. Many hormones and growth factors are involved in the regulation of this process. Among these, sex steroids are of crucial importance, especially during puberty. In long bones, endochondral bone formation occurs at the growth plate, a region of developing cartila

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2

Isaksson, Friman Erika. "Hormonal treatments and the breast : effects on sex steroid receptor expression and proliferation /." Stockholm : [Karolinska institutets bibl.], 2002. http://diss.kib.ki.se/2002/91-7349-182-9/.

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3

Cluning, Carmel. "Steroid receptor-associated immunophilins : influence of targeted knockdown and altered expression on receptor signalling." University of Western Australia. School of Medicine and Pharmacology, 2008. http://theses.library.uwa.edu.au/adt-WU2008.0215.

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[Truncated abstract] Steroid receptors belong to the superfamily of nuclear receptors, and include the androgen receptor (AR), estrogen receptors (ER[alpha] and ER[beta], glucocorticoid receptor (GR), mineralocorticoid receptor (MR), and the progesterone receptors (PRA and PRB). Before binding ligand, the receptor undergoes biochemical and structural modifications through a series of interactions with molecular chaperones and cochaperones all within a receptor heterocomplex. The mature receptor complexes with the major chaperone Hsp90, the stabilising cochaperone p23, and one member of a group

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4

Goold, Richard David. "Influence of endogenous female sex-steroids on mutagen metabolism." Thesis, Rhodes University, 1985. http://hdl.handle.net/10962/d1004919.

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Cytochrome P-450, the terminal oxidase of the metabolic mono-oxygenase system, is thought to exist in multiple forms, which have differing substrate specificities, and are variably inducible by different enzyme inducers. Many mutagens, themselves unreactive, require metabolic activation by one or more of these cytochrome P-450-dependent microsomal enzymes for mutagenic activity. Such mutagens may be detected in the Salmonella mutagenicity test only by the incorporation of an hepatic microsomal (59) fraction into the assay (as a first approximation to in vivo metabolism). Induction of the micro

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5

Trout, Amanda L. "SEX DIFFERENCES IN CELL DEATH AND STEROID HORMONE RECEPTORS IN CORTICAL EXPLANTS." UKnowledge, 2013. http://uknowledge.uky.edu/physiology_etds/6.

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Estrogens, such as the biologically active 17-b estradiol (E2) have many actions in the male and female brain. Not only does E2 regulate reproductive behavior in adults, it organizes and activates the brains of younger animals in a sex-specific manner. In addition, many human studies have shown E2 to provide protection against a variety of neurological disorders, including stoke. These studies have been controversial and depend largely on the type and timing of hormone replacement. Animal studies are much less controversial and clearly demonstrate a neuroprotective role for E2 following ischem

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6

Williams, Maro R. I. 1974. "Dehydroepiandrosterone action in the cardiovascular system." Monash University, Dept. of Medicine, 2002. http://arrow.monash.edu.au/hdl/1959.1/7927.

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7

Tasende, Celia. "Pituitary and uterine sex steriod receptors in ewes : seasonal and postpartum anoestrus, oestrous cycle and experimentally induced subnormal luteal phases /." Uppsala : Dept. of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences, 2005. http://epsilon.slu.se/200597.pdf.

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8

Meikle, Ana. "Reproductive endocrinology of prepubertal and anestrous ewes : regulation of uterine sex steroid receptors by ovarian hormones and effects of estradiol on gonadotropin secretion and follicular growth /." Uppsala : Swedish Univ. of Agricultural Sciences (Sveriges lantbruksuniv.), 2001. http://epsilon.slu.se/avh/2001/91-576-5915-X.pdf.

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9

Coulombe, Marie-andree. "Implication du sexe, des hormones gonadiques et de leurs métabolites dans la réponse nociceptive et la perception de la douleur." Thesis, Strasbourg, 2013. http://www.theses.fr/2013STRAJ099/document.

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Plusieurs variables biologiques, psychologiques, ainsi que des différences culturelles, ont été mises en cause afin d'expliquer la différence de perception de la douleur existante entre les hommes et les femmes. Il est connu que les hormones gonadiques influencent la réponse nociceptive chez l’animal et chez l’humain. Le cerveau a aussi la capacité de synthétiser ses propres "hormones sexuelles", les neurostéroïdes. L'objectif de cette thèse était: 1) évaluer les facteurs physiologiques et psychologiques influençant de perception de la douleur chez les hommes et les femmes, 2) évaluer l'implic

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10

Pedroso, Luciana de Britto. "Avaliação da possível diferença na sensibilidade dolorosa de ratos machos e fêmeas e da resposta de cada sexo a crotalfina, um analgésico tipo opióide." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/42/42136/tde-23012012-114018/.

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Evidências clínicas e experimentais têm sugerido a existência de diferenças na sensação de dor e na resposta a fármacos analgésicos entre machos e fêmeas. A crotalfina (CRF), um peptídeo inicialmente isolado e caracterizado no veneno de serpentes Crotalus durissus terrificus, apresenta efeito antinociceptivo, quando avaliado em diferentes modelos experimentais de dor aguda e crônica. O efeito deste peptídeo é de longa duração e mediado pela ativação de receptores opióides periféricos do tipo <font face=\"Symbol\">k e <font face=\"Symbol\">d. Contudo, os estudos com a crotalfina foram sempre re

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11

Roche, Jennifer. "Implication des récepteurs de la dopamine dans la régulation de l’axe gonadotrope lors de la période pré-ovulatoire chez le sandre, Sander lucioperca." Thesis, Université de Lorraine, 2018. http://www.theses.fr/2018LORR0234.

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Dans le cadre de la production de nouvelles espèces aquacoles, le sandre, Sander lucioperca, est devenu, depuis plusieurs années, une espèce d’intérêt piscicole en raison de sa valeur économique potentielle. Pour développer et pérenniser sa production aquacole, il est nécessaire de comprendre et maîtriser son cycle de reproduction ainsi que les mécanismes physiologiques mis en jeu afin d’obtenir des œufs et des juvéniles viables tout au long de l’année. Dans cet optique d’optimisation du contrôle du cycle, la dopamine apparaît, chez de nombreux téléostéens dont certains perciformes, comme un i

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12

Sheppard, Ashley Brianna. "Sex Differences in Nicotine-Conditioned Hyperactivity in a Model of Dopamine D2 Receptor Priming: Roles of Dopamine D2 and D3 Receptor Subtypes." Digital Commons @ East Tennessee State University, 2008. https://dc.etsu.edu/etd/1978.

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The aim of this investigation was to determine the effect of a nicotine-conditioned context on locomotor hyperactivity in an animal model of D2-priming, and whether conditioned hyperactivity could be blocked by the D2 antagonist eticlopride or the D3 antagonist nafadotride. D2-primed male rats showed enhanced nicotine sensitization as evidenced by statistically significant differences in horizontal activity. D2-primed female rats administered nicotine demonstrated an increased hypoactive response after initial sensitization and increased stereotypy. Eticlopride and nafadotride blocked sensitiz

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13

Englund, Katarina. "Hormonal regulation of sex steroid receptors and growth related genes in human myometrium and leiomyomas /." Stockholm, 2001. http://diss.kib.ki.se/2001/91-628-4706-6/.

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14

Rosenberg, Rachel Stacey. "The effects of plant-derived compounds on sex hormone receptors, implications for hormone-dependent cancer development and treatment." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ29298.pdf.

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15

Lundqvist, Johan. "Enzymatic Regulation of Steroidogenesis and Nuclear Receptor Activation : Special Focus on Vitamin D and Sex Hormones." Doctoral thesis, Uppsala universitet, Institutionen för farmaceutisk biovetenskap, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-151740.

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Enzyme-catalyzed reactions are important to regulate steroidogenesis and nuclear receptor activation. The present investigation examines the role of steroid metabolism catalyzed by CYP7B1 for regulation of hormone receptor activation and the effects of vitamin D on enzymatic regulation of steroidogenesis. The study reports data indicating that CYP7B1 can regulate estrogenic signaling by converting estrogens into inactive or less active metabolites. Similar results were obtained for CYP7B1-mediated metabolism of some androgen receptor ligands, indicating that CYP7B1 can be involved also in the

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16

Sabbaghian, Nelly. "Structure-function analysis of three widely dispersed point mutations in the hormone-binding domain of the androgen receptor." Thesis, McGill University, 1994. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=68254.

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Three point mutations have been found in the hormone-binding domain (HBD) of the human androgen receptor (hAR): one in the N-terminal end (Ile663Asn in a family with partial androgen insensitivity syndrome (PAIS)); one in the middle, (Leu820Val in a family with PAIS); and one in the C-terminal end (Pro903Ser, in a family with complete AIS). The positions 663 and 903 were the most terminal mutation sites in the HBD found to date. The three mutant hARs have been previously characterized biochemically in genital skin fibroblasts. In the family with the Leu820Val substitution, the mother and the g

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17

Pettersson, Hanna. "Steroid-Metabolizing Cytochrome P450 (CYP) Enzymes in the Maintenance of Cholesterol and Sex Hormone Levels." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-100787.

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Diss. (sammanfattning) Uppsala : Uppsala universitet, 2009.<br>Disputationsordförande;Professor Eva Brittebo, Inst. för Biovetenskap, Avd. för Toxikologi, Uppsala Universitet, UppsalaBetygsnämndens ledamöten; Docent Lena Ekström, Inst. för Laboratoriemedicin, Avd. för Klinisk Kemi, Karolinska Universitetssjukhuset, HuddingeDocent Ulf Diczfaluzy, Inst. för Laboratoriemedicin, Avd. för Klinisk Kemi, Karolinska Universitetssjukhuset, HuddingeProfessor Agneta Oskarsson, Inst. BVF, Avd. för farmakologi och toxikologi, SLU, Uppsala. Härtill 4 uppsatser.

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18

Kruijver, Franciscus Petrus Maria. "Sex in the brain gender differences in the human hypothalamus and adjacent areas : relationship to transsexualism, sexual orientation, sex hormone receptors and endocrine status /." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2004. http://dare.uva.nl/document/75961.

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19

Hébert-Losier, Andréa 1983. "Structural and functional characterization of a novel endogenous steroid, estradienolone (ED), in human pregnancy." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=116111.

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Our lab has previously reported the identification of a novel endogenous 19-nor steroid, estradienolone (ED), in pregnant women that strongly bound to sex hormone binding globulin. Estrogen-receptor related receptors (ERRs), which have no known natural ligands, are a family of orphan receptors consisting of 3 isoforms: ERRalpha, ERRbeta and ERRgamma. The ERRs have been shown to actively modulate estrogenic responses, to play an essential role in pregnancy, and are implicated in breast cancer prognosis. My results show that ED acts as an antagonist of the ERRalpha confirming preliminary results

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20

Ylikomi, Timo. "Sex-steroid-sensitive stromal cells in the chick oviduct and the bursa of Fabricius estrogen-induced and sexual maturation-associated progesterone receptor expression /." Tampere : University of Tampere, 1987. http://catalog.hathitrust.org/api/volumes/oclc/213858363.html.

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21

Roseau, Audrey. "Etude de la dynamique des interactions fonctionnelles entre le récepteur de la progestérone et ses corégulateurs transcriptionnels." Thesis, Paris 11, 2013. http://www.theses.fr/2013PA11T037.

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Le récepteur de la progestérone (PR) est un facteur de transcription hormono-régulé qui joue un rôle crucial dans la coordination de tous les aspects de la fonction de reproduction chez la femme. Pour activer ses gènes cibles, PR recrute de façon dynamique, séquentielle et combinatoire différents partenaires moléculaires : les corégulateurs transcriptionnels. Les coactivateurs de la famille p160 (Steroid Receptor Coactivators : SRC-1, -2, -3), dont l’expression est augmentée dans certains cancers hormono-dépendants, sont les partenaires privilégiés de PR. Au cours de ce travail, nous avons étu

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Martínez, Leandro 1979. "Estudo computacional dos mecanismos de dissociação do hormonio tireoidiano de seu receptor nuclear." [s.n.], 2003. http://repositorio.unicamp.br/jspui/handle/REPOSIP/248871.

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Orientadores: Munir S. Skaf, Igor Polikarpov<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Quimica<br>Made available in DSpace on 2018-08-03T18:40:35Z (GMT). No. of bitstreams: 1 Martinez_Leandro_M.pdf: 6462878 bytes, checksum: c8038405b68f9b7fff5d28835e72c249 (MD5) Previous issue date: 2003<br>Mestrado

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23

Bertrand, Philippe. "Couplages des recepteurs adenohypophysaires a l'adenylate cyclase : caracteristiques, localisation cellulaire et modulation par l'oestradiol." Paris 6, 1987. http://www.theses.fr/1987PA066264.

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24

David, Daniela Dantas. "Presença do sistema melatoninégico e seu papel no ciclo de muda do siri-azul Callinectes sapidus (Crustacea Brachyura)." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/41/41135/tde-20092018-111822/.

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Uma das marcantes características morfológicas e funcionais dos crustáceos e de outros artrópodes é a presença de um exoesqueleto que cria uma barreira física para o crescimento desses animais. Nos crustáceos, a muda é um evento cíclico, dividido em 5 estágios, e um deles compreende a troca desse exoesqueleto, permitindo o aumento de tamanho. O início, período e a frequência do ciclo de muda dependem da idade e do sexo do animal e de fatores ambientais e fisiológicos. Hormônios como os ecdiesteróides e o hormônio inibidor da muda produzidos e secretados pelos órgãos Y e X, respectivamente, atu

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25

Schontz, Didier. "Melanome malin : hormonodependance ou independance : differences selon le sexe : recepteurs et traitements hormonaux." Bordeaux 2, 1988. http://www.theses.fr/1988BOR25066.

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26

Voorhees, Grace Kathryn. "Understanding the Role of Androgen Receptor Signaling in Modulating p38-alpha Mitogen-Activated Protein Kinase in Experimental Autoimmune Encephalomyelitis." ScholarWorks @ UVM, 2019. https://scholarworks.uvm.edu/graddis/1144.

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Multiple Sclerosis (MS) is an inflammatory autoimmune disease of the central nervous system, characterized by axonal demyelination and multifocal inflammation. Like many autoimmune diseases, it is a sexually dimorphic disease, being 3-4 times more common in females than in males. p38α MAP kinase (MAPK) has an integral role in modulating inflammatory processes in autoimmunity. Conditionally ablating p38α MAPK in myeloid cells in B6 mice shows a sex difference in the animal model of MS, experimental autoimmune encephalomyelitis (EAE). In the absence of sex hormones, this sex difference was rever

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Masseoud, Feda N. "Estrogen-Induced Modulation of Innate and Adaptive Immune Function." Digital Archive @ GSU, 2009. http://digitalarchive.gsu.edu/biology_diss/62.

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Host defense against infection and disease relies on the reciprocal communication between the immune and neuroendocrine systems where sex hormones exert negative and positive feedback actions on immune functions. Indeed, sex hormones have been implicated in gender dimorphic immune response and in the potentiation of immune-related disorders. The female hormone estrogen plays a role as an immunomodulator and may exert immunosuppressive and immunostimulatory effects. Though many studies focus on estrogen’s role in immunity within the female reproductive tract and autoimmunity, the modulatory eff

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Safi, Rémi. "Etude de la férutinine et de ses analogues : hémisynthèse et activité anticancéreuse vis-à-vis des lignées cellulaires hormono-dépendantes." Thesis, Toulouse 3, 2015. http://www.theses.fr/2015TOU30357/document.

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Les oestrogènes peuvent favoriser la croissance, la promotion et la progression des cancers hormono-dépendants tels que le cancer du sein, de la prostate et des ovaires. Certains métabolites secondaires de plantes constituent une source importante de phyto-œstrogènes, capables de réduire le risque du cancer en antagonisant les fonctions des hormones. La férutinine (FRT), est une phyto-œstrogène biologiquement active extraite des racines de Ferula hermonis, espèce endémique du Liban. Plusieurs études ont été menées sur l'activité œstrogénique et anticancéreuse de la FRT, cependant son activité

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Dalmazzo, Andressa. "Imunolocalização e expressão do receptor de ocitocina (OTR) e da globulina ligadora de hormônios sexuais (SHBG) em testículo e epidídimo de cães e suas correlações com a qualidade espermática." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/10/10131/tde-30092016-122716/.

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A ocitocina (OT) é um neuropeptídio hipotalâmico, que dentre suas funções na fêmea destaca-se a contração uterina durante o parto e a ejeção do leite. No entanto, estudos vêm demonstrando importantes funções endócrinas e parácrinas no trato reprodutivo masculino. Evidenciando a possível ação conjunta entre OT e a Globulina ligadora de hormônios sexuais (SHBG). Entretanto, em cães não existem informações disponíveis quanto sua atuação. Assim, estudos direcionados aos receptores de ocitocina (OTR) e SHBG e suas funções no sistema reprodutor masculino, mais especificamente na fisiologia espermáti

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GRIZARD, DELORME GENEVIEVE. "Fonction leydigienne et cryptorchidie experimentale chez le rat." Clermont-Ferrand 2, 1988. http://www.theses.fr/1988CLF2E408.

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Rodrigues, Natália Martins Bittar. "Distribuição da ghrelina e de seu receptor na mucosa gástrica de ratos submetidos ao desmame precoce: efeitos sobre a proliferação celular epitelial." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/42/42134/tde-13112012-094406/.

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Investigamos a distribuição de ghrelina e de seu receptor (GHS-R) na mucosa gástrica de ratos durante a terceira semana de vida pós-natal e avaliamos o efeito do desmame precoce sobre estas moléculas. Estudamos também a participação da ghrelina no controle da proliferação celular do epitélio gástrico, e para tanto utilizamos a administração de um antagonista. Detectamos o aumento do número de células imunomarcadas para ghrelina nos animais desmamados precocemente e observamos que nem a expressão de GHS-R nem a concentração proteica deste receptor foram alteradas pela mudança da dieta. O uso do

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Bailleul, Serge. "Heterogeneite des recepteurs aux oestrogenes et a la progesterone dans les tumeurs mammaires humaines : relation avec l'hormonodependance." Caen, 1988. http://www.theses.fr/1988CAEN2026.

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33

Amet, Yolande. "Stéroi͏̈des sexuels et glandes à sécrétion externe de la peau : Interactions stéroi͏̈des-récepteurs et répercussions physiologiques." Brest, 1986. http://www.theses.fr/1986BRES2019.

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La glande uropygienne de la caille male est un organe cible des androgenes, elle possede des recepteurs aux androgenes qui ont ete mis en evidence. Mise au point d'une technique qui permet de mesurer a la fois les recepteur actives et non actives. La glande uropygienne est androgeno-dependante: la testosterone entraine une activation rapide des recepteurs des androgenes suivie d'une augmentation de leur concentration cellulaire, c'est le compose le plus efficace de tous les androgenes. L'oestradiol et la progesterone se comportent comme des anti-androgenes par competition au niveau du recepteu

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Legendre, Marie. "Implication du récepteur de la ghréline en pathologie humaine : caractérisation d’une nouvelle étiologie des maladies de la croissance et de ses mécanismes moléculaires." Paris 6, 2010. http://www.theses.fr/2010PA066297.

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La ghréline, ligand endogène du Growth Hormone Secretagogue Receptor (GHSR), constitue la seule hormone orexigène connue à ce jour et stimule fortement la sécrétion d’hormone de croissance (GH). Ces propriétés font du GHSR une cible potentielle dans le traitement des maladies de la croissance et de la balance énergétique. Le séquençage du gène GHSR chez 290 patients présentant un déficit isolé en GH ou une petite taille idiopathique a permis d’identifier 2 mutations tronquantes (W2X, c. 370delG) et 6 variations faux-sens (L42V, A204E, V216A, R237W, L311F, A358T) au sein de 8 familles indépenda

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Breuiller, Michelle. "Les recepteurs adrenergiques dans le myometre humain gravide : implication des recepteurs beta-adrenergiques chez la rate au moment de la parturition." Paris 7, 1988. http://www.theses.fr/1988PA077019.

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Cayrol, Christian. "Recherches sur l'expression fonctionnelle de genomes diploides et polyploides chez l'amphibien urodele, pleurodeles waltl." Toulouse 3, 1986. http://www.theses.fr/1986TOU30020.

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Tusset, Cíntia. "Pesquisa de mutações na neurocinina B e no seu receptor em pacientes com distúrbios puberais centrais idiopáticos." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/5/5135/tde-03092012-090655/.

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Mutações inativadoras nos genes TAC3 e TACR3, os quais codificam a neurocinina B (NKB) e o seu receptor NK3R, respectivamente, foram descritas em pacientes com hipogonadismo hipogonadotrófico isolado (HHI) normósmico. A partir desse achado, hipotetizamos que mutações ativadoras na NKB e/ou NK3R resultariam na secreção prematura de GnRH e, consequentemente, no desenvolvimento de puberdade precoce dependente de gonadotrofinas (PPDG). Nesse estudo, investigamos a presença de mutações ativadoras e/ou polimorfismos nos genes TAC3 e TACR3 em pacientes com PPDG, bem como mutações inativadoras e/ou po

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Ninov, Kerli. "Identificação de polimorfismos no gene da leptina e de seu receptor em duas linhagens de aves e associação com características de desempenho e carcaça." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/11/11139/tde-05032007-162413/.

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A tendência da indústria em produzir alimentos mais saudáveis, com menos gordura vem aumentando sensivelmente. O desafio do melhoramento nos dias atuais é melhorar a qualidade da carcaça dos frangos juntamente com a redução nos teores de gordura, que é uma exigência do mercado consumidor. A leptina é um hormônio polipeptídico secretado principalmente pelo tecido adiposo com um importante papel na regulação da ingestão de alimentos, metabolismo de energia e reprodução. O gene da leptina e seu receptor vem sendo objeto de intensa investigação representando excelentes genes candidatos para deposi

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Roques, Beatrice. "Bases mécanistiques des effets d'un insecticide agrovétérinaire, le fiproni, et/ou de ses métabolites sur la fonction thyroïdienne chez le rat." Thesis, Toulouse, INSA, 2012. http://www.theses.fr/2012ISAT0029/document.

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Le fipronil, insecticide largement utilisé, est un perturbateur thyroïdien chez le rat modulant le catabolisme hépatique des hormones thyroïdiennes. Ses effets chez le mouton, considéré comme un modèle plus pertinent que le rat pour étudier une régulation de la fonction thyroïdienne chez l'Homme, sont plus limités. Le but de cette thèse était de caractériser au niveau hépatique le mode d'action du fipronil sur la fonction thyroïdienne en s'intéressant 1) au rôle potentiel du principal métabolite du fipronil formé in vivo, le fipronil sulfone, et 2) aux différences interspécifiques de métabolis

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Walter, Philippe. "Le recepteur de l'oestradiol humain : isolement, sequence et expression de l'adnc et homologie avec l'oncogene erb-a." Université Louis Pasteur (Strasbourg) (1971-2008), 1986. http://www.theses.fr/1986STR13003.

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Cassanelli, Sylvie. "Analyse in situ de l'hétérogénéité d'expression des récepteurs de la progesterone dans les cellules tumorales mammaires." Université Joseph Fourier (Grenoble), 1995. http://www.theses.fr/1995GRE10118.

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La mise en evidence des recepteurs de la progesterone (rp) dans les cellules tumorales mammaires revele a l'echelon cellulaire une heterogeneite d'expression. Les travaux presentes dans cette these ont pour objectif l'etude des origines possibles de cette heterogeneite. Deux lignees tumorales mammaires mcf-7 et t47-d ont ete utilisees ainsi que des empreintes de tumeurs. La quantification par analyse d'images de plusieurs immunomarquages fluorescents (rp-ki-67 ou brdu-adn) a montre que l'expression des rp est, en partie, liee a la cinetique de proliferation des cellules sur les trois modeles e

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Avet, Charlotte. "Étude des mécanismes contrôlant l'efficacité et la spécificité de la signalisation du récepteur de la GnRH : identification et rôle de la protéine partenaire SET." Thesis, Paris 11, 2013. http://www.theses.fr/2013PA11T091.

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La fonction de reproduction est sous le contrôle de la neurohormone hypothalamique GnRH qui régule la synthèse et la libération des gonadotropines hypophysaires. La GnRH agit par l’intermédiaire d’un récepteur couplé aux protéines G exprimé à la surface des cellules gonadotropes, le récepteur de la GnRH (RGnRH). Ce récepteur, chez les mammifères, a la particularité d’être dépourvu de queue C terminale ce qui le rend insensible aux systèmes classiques de désensibilisation. Ainsi, les mécanismes qui régulent l’efficacité et la spécificité de sa signalisation demeurent mal connus. Nous avons rech

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Brannan, Katla Jorundsdottir. "Telomerase and its reverse transcriptase subunit TERT : identification and oestrogenic modulation of telomerase transcription in two aquatic test species - European Purple Sea Urchin (Paracentrotus Lividus) and Rainbow Trout (Oncorhynchus Mykiss)." Thesis, University of Exeter, 2012. http://hdl.handle.net/10871/16556.

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A plethora of naturally-produced steroid hormones, or artificial homologues of them, are being introduced into the aquatic and terrestrial environments each year. Two examples of these are the natural oestrogen 17ï¢-oestradiol (E2) and the oestrogen receptor antagonist, Bisphenol A (BPA), both of which target the ribonucleoprotein telomerase through upregulation of its telomerase reverse transcriptase component, TERT. The main objectives of this study were firstly to isolate and characterize the actual mRNA sequence for the telomerase catalytic subuninit, Tert, in rainbow trout (Oncorhynchus

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Peycelon, Matthieu. "Mécanismes physiopathologiques impliqués dans la différenciation du tractus génital masculin." Electronic Thesis or Diss., Sorbonne université, 2019. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2019SORUS461.pdf.

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Introduction. L’étiopathogénie de l’hypospadias reste largement discutée, faisant intervenir des facteurs endocriniens, génétiques, vasculaires et environnementaux. Objectifs. Étudier les mécanismes génétiques impliquées dans la différenciation sexuelle masculine. Matériels et méthodes. Une cohorte de 284 patients a été établie depuis 2011 pour séquençage de l’ADN lymphocytaire, préputial et urothélial de trois gènes candidats (NR5A1, MAMLD1, AR). Une analyse pangénomique (puce à ADN et Whole Exome Sequencing (WES)) a été réalisée. Le registre REMAPAR a été utilisé pour analyser l’association

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Kouidhi-Lamloum, Wided. "Effets de deux xénohormones, la génistéine et la vinclozoline, sur le développement et les fonctions exocrines et endocrines des glandes salivaires submandibulaires de rats Wistar Han : influence de la période d'exposition en fonction de l'âge et du sexe." Phd thesis, Université de Bourgogne, 2012. http://tel.archives-ouvertes.fr/tel-00935290.

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Les glandes salivaires sont des glandes mixtes : la salive (produit exocrine) estimpliquée dans le maintien de l'homéostasie buccale alors que les secrétions endocrines (ex :facteurs de croissance) ont un rôle physiologique (gamétogénèse, ostéogenèse,hypertension...) Chez les mammifères, elles affichent un dimorphisme sexuel qui laisseentrevoir une sensibilité éventuelle à des xeno-hormones.Ce mémoire présente l'action de la génistéine (phyto-oestrogène) et/ou de la vinclozoline(anti-androgène) sur la glande submandibulaire (SM) de rat lors d'une exposition précoce viala mère (gestation-lactat

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Tomás, Joana Filipa Melfe. "Taste receptors in the Choroid Plexus are functional and regulated by sex hormones." Doctoral thesis, 2020. http://hdl.handle.net/10400.6/11162.

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The choroid plexuses (CPs) are highly vascularized structures constituted by a single layer of epithelial cells that project into the brain ventricles. The CPs are the main site of cerebrospinal fluid (CSF) production and constitute the Blood-CSF Barrier (BCSFB), holding high relevance in the surveillance of the CSF chemical composition. These structures contribute for the synthesis of biological compounds essential for the functioning and protection of the central nervous system (CNS) against neurotoxic insults. The expression of taste signalling pathway components in the CPs and its re

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Rudolph, Sara. "A review of genetic polymorphisms in the receptors for gonadotropic and sex hormones in polycystic ovary syndrome." Thesis, 2017. https://hdl.handle.net/2144/23991.

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Polycystic ovary syndrome is a complex, heterogeneous disease that affects 5-10% of reproductive-aged women. It is characterized by clinical or biochemical hyperandrogenism, oligo-anovulation, and polycystic ovary morphology. Instigating endocrine findings include aberrantly rapid gonadotropin-releasing hormone pulsatile secretion, elevated luteinizing hormone, sub-optimal levels of follicle-stimulating hormone, and hyperandrogenism. Metabolic symptoms are also present including hyperinsulinemia, insulin resistance, and dyslipidemia. These endocrine and metabolic findings are also accompanied

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McCarthy, Anna R. "Biological activity of steroid analogues : synthesis and receptor/enzyme interactions : a thesis submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Chemistry at the University of Canterbury /." 2006. http://library.canterbury.ac.nz/etd/adt-NZCU20060724.203418.

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Yao, Chun-Lien, and 姚俊蓮. "Mechanism of androgenic inhibition on stress response – the role of sex hormone receptors at the preoptic nucleus." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/63687757940249775385.

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碩士<br>慈濟大學<br>生理暨解剖醫學碩士班<br>99<br>It is well known that there is sexual difference on stress responses. Studies indicate that testosterone (T) has an inhibitory effect on stress-induced hypothalamic-pituitary-adrenal (HPA) activation. Androgen receptor (AR) is found throughout the central nervous system, but the paraventricular nucleus in the hypothalamus (PVH), the integrator of HPA activity, expresses little. Evidence shows that medial preoptic neucleus (MPN), an AR bearing nucleus, may play a critical role on modulating the effects of T on stress-induced HPA axis activation. The mechanism,

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Yeh, Chu-Yin. "Cloning and expression of a corticoid receptor in the sea lamprey (Petromyzon marinus)." Diss., 2008.

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Thesis (M.S.)--Michigan State University. Dept. of Physiology, 2008.<br>"Committee members, Weiming Li, Richard Miksicek, and Cheryl Sisk"--Acknowledgments. Title from PDF t.p. (viewed on Aug. 4, 2009) Includes bibliographical references (p. 51-54). Also issued in print.

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