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Dissertations / Theses on the topic 'Hormones – Synthesis'

Author: Grafiati

Published: 4 June 2021

Last updated: 14 February 2022

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1

Rodway, Marie R. "Effector mechanisms in the endocrine control of steroidogenesis." Thesis, University of British Columbia, 1990. http://hdl.handle.net/2429/31411.

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Production of hormones in the ovary is controlled by endocrine, paracrine, autocrine and intracrine influences. Similar controls may exist in the placenta. I wished to investigate the involvement of second messengers in the action of hormones in control of hormonogenesis in rat ovary and human placenta. The second messengers involved in the action of gonadotropin-releasing hormone (GnRH) and prostaglandin (PG) F₂[formula omitted] were investigated in rat granulosa and luteal cells. As well, the endocrine role of GnRH in the placenta and the possible second messengers involved were investigated

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2

Athmani, Salah. "Synthesis of cytokinin analogues." Thesis, University of Salford, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.304608.

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3

Harrison, Polly A. "Partial synthesis of selected gibberellins." Thesis, University of Bristol, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.294577.

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4

Sienna, Nancy. "Regulation of ribosomal protein L32 synthesis by hormones." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0027/NQ51047.pdf.

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5

Arslan, Ali. "Parturient hormones : cytokine, and oxytocin effects on prostaglandin synthesis." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape16/PQDD_0005/NQ29877.pdf.

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6

Grundler, Claudia. "Design and synthesis of ring D modified steroidal hormones." Doctoral thesis, University of Cape Town, 1992. http://hdl.handle.net/11427/17372.

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Bibliography: pages 183-190.<br>Cycloadditions of steroidal 14,16-dienes with ketene equivalents were investigated, as routes to estradiol and estriol analogues. The cycloadduct of 3-methoxyestra-1,3,5(10), 14,16-pentaen-17-yl acetate and 2-chloroacrylonitrile underwent an unprecedented tandem rearrangement, on attempted alkaline hydrolysis to the corresponding ketone. This product, obtained in ca. 90% yield, was formulated as (16¹R)-3-methoxy-17-oxo-15β,16¹-cyclo-14,16β-ethano-14β-estra-1,3,5(10)-triene-16¹-carbonitrile. The chemistry of the 16¹-carbonitrile was extensively studied and, in ad

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7

Jardine, Mogamad Anwar. "Synthesis and structure activity relationships of ring D modified steroidal hormones." Doctoral thesis, University of Cape Town, 1995. http://hdl.handle.net/11427/17900.

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Includes bibliographical references.<br>The synthesis of steroidal 14α,16-methano, 14α,17-methano-, 14α,17-ethano- and 14α,17-propano estradiol analogues as well as 14α-alkyl and 14α-functionalised-alkyl estradiol analogues was investigated. Furthermore, the synthesis of 17β-hydroxy-17α, 14-(epoxymethano)androst-4-en-3-one was undertaken and acid-mediated rearrangement of the 14,17-etheno bridged testosterone analogue gave the 14,16-ethano analogue of androst-4-en-3,17-dione. Established ring D cycloaddition and oxidative cleavage methodology gave ring D 14α-formyl and 14α, 17α-diformyl compou

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8

Marashi, Khadijeh Kathy 1960. "SOLID PHASE SYNTHESIS OF UNSATURATED ANALOGUES OF OXYTOCIN AND THEIR MEDICINAL APPLICATION (PEPTIDES, HORMONES, ANTAGONISTS, CONFORMATION, RECEPTORS)." Thesis, The University of Arizona, 1986. http://hdl.handle.net/10150/275515.

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9

Russell, Keith Casey. "Design and asymmetric synthesis of unusual amino acids for incorporation into peptide hormones." Diss., The University of Arizona, 1992. http://hdl.handle.net/10150/185750.

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One of the central goals of peptide and protein chemistry is the development of peptides with specific biological, chemical, and physical properties. An important method directed towards attaining this goal is the use of conformationally restricted amino acids. The conformationally restricted amino L-isomers of 2'-methyltyrosine, 2',6'-dimethyltyrosine, erythro- and threo-2',β-dimethyltyrosine, and erythro- and threo-2',6',β-trimethyltyrosine were asymmetrically synthesized in good yields and high optical purities. The synthesis of these compounds was based on the chiral boron imidate methodol

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10

Wrigley, J. O. L. "Protein synthesis in isolated muscle preparations from carp (Cyprinus carpio) : The influence of amino acids and hormones." Thesis, University of Bradford, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.379815.

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11

Feng, Jun. "A kinetic investigation of recombinant xenopus laevis amidating enzymes." Diss., Georgia Institute of Technology, 1999. http://hdl.handle.net/1853/30084.

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12

Ververidis, Philippos. "Characterisation and partial purification of the enzyme responsible for ethylene synthesis from 1-aminocyclopropane-1carboxylic acid in plant tissues." Thesis, University of Reading, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.303175.

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13

SOARES, CARLOS R. J. "Sintese de prolactina humana em celulas de ovario de hamster chines (CHO)." reponame:Repositório Institucional do IPEN, 2000. http://repositorio.ipen.br:8080/xmlui/handle/123456789/10770.

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14

Foster, Michael Scott. "Design, synthesis, kinetic analysis, molecular modeling, and pharmacological evaluation of novel inhibitors of peptide amidation." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2008. http://hdl.handle.net/1853/31816.

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Thesis (Ph.D)--Chemistry and Biochemistry, Georgia Institute of Technology, 2009.<br>Committee Chair: Dr. Sheldon W. May; Committee Member: Dr. James C. Powers; Committee Member: Dr. Nicholas Hud; Committee Member: Dr. Niren Murthy; Committee Member: Dr. Stanley H. Pollock. Part of the SMARTech Electronic Thesis and Dissertation Collection.

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15

SUZUKI, MIRIAM F. "Síntese e caracterização de prolactina de camundongo (mPRL) e de seu análogo (S177D-mPRL)." reponame:Repositório Institucional do IPEN, 2011. http://repositorio.ipen.br:8080/xmlui/handle/123456789/9955.

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16

Thompson, Jeremy. "Pharmacological evaluation of in vivo inhibitors of peptide amidation : 2 Biological synthesis of poly(3-hydroxybutyrate)." Thesis, Georgia Institute of Technology, 2002. http://hdl.handle.net/1853/27075.

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17

Hoste, Candice. "Caractérisation du complexe générateur d'H2O2 DUOX/DUOXA: étude de son rôle dans la biosynthèse des hormones thyroïdiennes et dans les mécanismes de défense." Doctoral thesis, Universite Libre de Bruxelles, 2011. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209804.

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Les espèces réactives de l’oxygène ont initialement été identifiées comme des produits délétères dérivés du métabolisme aérobie. Il est maintenant accepté que ces espèces sont produites de manière régulée par des enzymes et interviennent dans des fonctions cellulaires telles que la défense immunitaire, la signalisation intracellulaire, la biosynthèse des hormones et la modification de matrice extracellulaire. Les NADPH (Nicotinamide Adénine Dinucléotide Phosphate) oxydases (NOX) forment une famille d’enzymes transmembranaires capables de former de l’anion superoxyde (O2.-) par transfert d’élec

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18

Leung, Ching-man, and 梁靜雯. "Characterization of two auxin-induced ACC synthase genes in tomatoes." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B36748845.

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19

McAdory, Louis E. "CHEMICAL SYNTHESIS, BACTERIAL EXPRESSION, AND CHARACTERIZATION OF PRO-GNRH/GAP, A PRECURSOR PROTEIN OF TWO BIOLOGICAL ACTIVE PEPTIDE HORMONES." VCU Scholars Compass, 1998. https://scholarscompass.vcu.edu/etd/5233.

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Two biologically active peptides, gonadotropin releasing hormone (GnRH) and GnRH associated peptide (GAP) are both derived from a common prohormone precursor protein, pro-GnRH/GAP. Both peptides are cosecreted from hypothalamic neurosecretory granules and are involved in the regulation of mammalian reproduction. A calcium dependent, neutral pH serine protease discovered in this laboratory, GAP-releasing enzyme, is the most likely processing enzyme of pro-GnRH/GAP. GAP-releasing enzyme is immunologically related to PC1/3, a member of the prohormone convertase (PC) class of processing endoprotei

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20

Xiao, Chaowu. "Effect of interferon-[tau] and steroid hormones on the expression of genes involved in the prostaglandin synthesis in bovine endometrial cells." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ42296.pdf.

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21

Underhill, Brian Kimball. "The influence of Leptin on metabolic expenditure and thermogenesis during thyroid hormone (T₃) suppression in the obese (OB/OB) mouse." CSUSB ScholarWorks, 2000. https://scholarworks.lib.csusb.edu/etd-project/1767.

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22

Joyce, Belinda Jane. "Elastin synthesis in the fetal sheep lung in vivo : effects of physical, metabolic and endocrine factors." Monash University, Dept. of Physiology, 2004. http://arrow.monash.edu.au/hdl/1959.1/5263.

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23

McFadden, Thomas Bernard. "Influence of hormones on synthesis and secretion of milk proteins by mammary tissue from male and female cattle of beef and dairy breeds." Thesis, Virginia Polytechnic Institute and State University, 1985. http://hdl.handle.net/10919/101238.

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The ability of mammary tissue from prepubertal bulls and heifers of beef and dairy breeds to respond to hormonal stimuli through synthesis and secretion of milk proteins was studied. Experimental animals were six to eight month old Angus and Holstein cattle. All subjects were injected with estradiol and progesterone for seven days and slaughtered on day 15. Mammary tissue was explanted and cultured for 96 h in basal medium (B) which contained hormones necessary for maintenance, or stimulatory medium (P), further supplemented with prolactin. Selected cultures were incubated for 24 h in B or P m

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24

Urs, Aarti N. "Reciprocal binding of sphingosine and phosphatidic acid to steroidogenic factor 1 regulates the transcription of CYP17." Thesis, Available online, Georgia Institute of Technology, 2005, 2005. http://etd.gatech.edu/theses/available/etd-11212005-102620/.

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Thesis (M. S.)--Biology, Georgia Institute of Technology, 2006.<br>Donald Doyle, Committee Member ; Harish Radhakrishna, Committee Member ; Alfred Merrill, Committee Member ; Marion Sewer, Committee Chair Includes bibliographical references.

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25

FALLAH, YACOUBI BOUCHRA. "Etude electrophoretique mono et bidimensionnelle des proteines du tractus genital du foetus de lapin : ontogenese, influence du sexe et des hormones androgenes." Clermont-Ferrand 2, 1988. http://www.theses.fr/1988CLF2S906.

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26

Bergamin, Bruna. "Polímeros biomiméticos híbridos para substâncias estrogênicas visando desenvolvimento de sensores para aplicação na área biotecnológica /." Araraquara, 2017. http://hdl.handle.net/11449/151076.

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Orientador: Maria Del Pilar Taboada Sotomayor<br>Banca: Luis Francisco Moreira Gonçalves<br>Banca Débora Gonçalves<br>Resumo: O desenvolvimento de métodos analíticos cada vez mais seletivos e sensíveis é de grande importância para uma melhor qualidade na determinação de espécies químicas, aumentando assim a confiabilidade dos resultados obtidos. Com isso, o emprego e otimização das etapas de separação/concentração se faz necessário. O emprego de polímeros molecularmente impressos (do inglês - "Molecularly Imprinted Polymers" - MIP) tem demonstrado ser uma eficiente ferramenta analítica com gra

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27

MURATA, YOKO. "Sintese e caracterizacao do hormonio tireotrofico humano recombinante (rec-hTSH) contendo uma sub unidade beta quimerica (rec-hTSHbeta-CTEP hCGbeta)." reponame:Repositório Institucional do IPEN, 1995. http://repositorio.ipen.br:8080/xmlui/handle/123456789/10432.

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28

Riman, Tomas. "An epidemiologic study of epithelial ovarian malignancies : with a focus on hormone-related factors /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-362-7/.

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29

Moss, Cheryl Anne. "Structure-conformation-activity studies of the melanin concentrating hormone (MCH)." Thesis, University of Bath, 1990. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.237223.

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30

Sheward, William John. "Thyrotrophin releasing hormone, somatostatin and luteinizing hormone releasing hormone : aspects of their synthesis, release and actions." Thesis, University of Edinburgh, 1986. http://hdl.handle.net/1842/20183.

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31

Hobbs-Mallyon, David. "Synthetic studies on tricyclospirodienones." Thesis, University of Nottingham, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.315042.

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32

WILKES, BRIAN CRAIG. "SYNTHESIS AND COMPARATIVE ACTIVITIES OF POTENT ALPHA-MELANOTROPIN ANALOGUES AND PREPARATION OF MELANIN CONCENTRATING HORMONE." Diss., The University of Arizona, 1985. http://hdl.handle.net/10150/188060.

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A number of α-melanotropin analogues have been prepared. Insight towards the development and understanding of the functional roles of each of the amino acid residues important for high melanotropic potency in a number of biological systems was studied. The melanotropin analogue Ac- α-MSH₄₋₁₂-NH₂ contains all of the structural requirements necessary for obtaining full biological potency on the lizard (Anolis carolinensis) melanophore and S-91 mouse melanoma. On the frog (Rana pipiens) melanophore, the melanotropin analogue Ac-[Nle⁴]-α-MSH₄₋₁₃-NH₂ possesses full melanotropic potency relative to

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33

Balthasar, Nina. "Transgenic studies of growth hormone secretagogues physiology." Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.248212.

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34

Khan, Usman 1980. "Peroxidase-catalysed oxidation of natural and synthetic hormones." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=98980.

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One of the fastest growing concerns in the wastewater treatment industry is the presence of estrogenic compounds in wastewater effluents that may threaten the reproductive success and development of aquatic organisms. The fact that such contaminants have been detected in surface waters at potentially detrimental levels indicates that conventional treatment plants are unable to effectively remove them; hence, supplementary treatment technologies must be considered. As one of these, enzymatic treatment offers numerous advantages which make such a treatment methodology almost tailor-made for the

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35

Jabbar, Ghulam. "Melengestrol acetate and norgestomet for the induction of synchronized estrus in seasonally anovular ewes." Thesis, This resource online, 1993. http://scholar.lib.vt.edu/theses/available/etd-06232009-063050/.

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36

Koubovec, Dominique J. B. M. "An investigation into the molecular mechanism of action of the progestins, medroxyprogesterone acetate and norethisterone acetate." Thesis, Stellenbosch : Stellenbosch University, 2004. http://hdl.handle.net/10019.1/70116.

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Thesis (PhD)--Stellenbosch University, 2004.<br>ENGLISH ABSTRACT: Although the progestins medroxyprogesterone acetate (MPA) and norethisterone acetate (NET-A) are widely used in reproductive therapy, the steroid receptors and their target genes involved in the actions of MPA and NET-A are not well understood. Surprisingly, it had not yet been investigated whether doses of MPA and NET-A used for contraception and HRT cause significant side effects through various target genes via the glucocorticoid receptor (GR). In this thesis results of in vitro studies showed that, MPA, like dexamethas

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37

Talbi, Oussama. "Synthesis of Homo A-CD Estrogens for Potential Use in Hormone Replacement Therapy." Thesis, Université d'Ottawa / University of Ottawa, 2015. http://hdl.handle.net/10393/32082.

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Hormone replacement therapy (HRT) has been subject to much debate due to concerns that long term use of such treatment of menopause increases the risk of breast and uterine cancer. This is thought to be caused by estradiol (1) binding to the estrogen receptor α (ERα) resulting in increased cell proliferation. Another possible mechanism relates to toxicity of the estrodiol metabolites, which are thought to be genotoxic ortho-quinones. In a previous project, a series of A-CD estrogens (2) were synthesised as non-carcinogenic estradiol agonists where the cis CD ring junction was thought to be the

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38

Davis, Danyetta Denise. "Investigation of the pleiotrophic effects of a series of isoflavonoid analogues in hormone dependent and hormone independent breast cancer cells." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1180124283.

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39

Areiza, Maria. "Ecdysis Triggering Hormone and its Role in Juvenile Hormone Synthesis in the Yellow-fever Mosquito, Aedes aegypti." FIU Digital Commons, 2014. http://digitalcommons.fiu.edu/etd/1147.

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Ecdysis triggering hormone (ETH) is a neuropeptide known for its role in the orchestration of ecdysis. However, its role in the regulation of Juvenile Hormone (JH) synthesis is unknown. In Aedes aegypti, JH is synthesized by the corpora allata (CA) and titers are tightly regulated by allatoregulatory factors. In this study I describe the effect of ETH on JH synthesis during the late pupal stage and in the adult female after blood feeding. Analysis of ETH receptor (ETHRs) expression showed that ETHRs are present in both the CA and the corpora cardiaca (CC), a neurohemal organ. The data suggest

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40

Martin, René. "Neuartige Myosin ATPase-Inhibitoren auf der Basis polyhalogenierter Pyrrolalkaloide und stereoselektive Synthese hormonell aktiver Steroide." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2009. http://nbn-resolving.de/urn:nbn:de:bsz:14-ds-1231328688848-12720.

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Während meiner Dissertation beschäftigte ich mich mit der Synthese von polyhalogenierten Pyrrolalkaloiden. Im Zentrum der Darstellung dieser Verbindungen stand die von mir in meiner Diplomarbeit erfolgreich zur Synthese von Pentabrompseudilin angewandte silber-katalysierte Cyclisierung von N-tosylsubstituierten Homopropargylaminen. So konnte das Pentachlorpseudilin in der zweiten Totalsynthese überhaupt sowie mehrere gemischt halogenierte synthetische Derivate aufgebaut werden. Diese Verbindungen konnten in einer Kooperation mit Herrn Prof. Gutzeit aus der Fachrichtung Biologie der TU Dresden

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41

Monteserin, Garcia Jose Luis. "Regulation of pituitary growth hormone synthesis by NAD+ dependent deacetylase Sirt1." Diss., Ludwig-Maximilians-Universität München, 2014. http://nbn-resolving.de/urn:nbn:de:bvb:19-171129.

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42

Dodd, S. C. "The hormonal control of #alpha#-lactalbumin and #beta#-lactoglobulin in pig mammary gland." Thesis, University of York, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.234448.

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43

Fang, Min. "Removal of Natural and Synthetic Steroid Hormones through Constructed Wetland Microcosm." University of Toledo / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1292943388.

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44

Fan, Xiaohui. "Uroguanylin : molecular cloning and characterization of a potential natriuretic hormone /." free to MU campus, to others for purchase, 1997. http://wwwlib.umi.com/cr/mo/fullcit?p9841285.

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45

CODY, WAYNE LIVINGSTON. "SYNTHESIS, BIOLOGICAL ACTIVITY AND CONFORMATIONAL ANALYSIS OF FRAGMENT ANALOGUES OF ALPHA-MELANOTROPIN (PEPTIDE, STRUCTURE-FUNCTION, PHENYLGLYCINE, NMR, TETRAHYDROISOQUINOLINE-3-CARBOXYLATE)." Diss., The University of Arizona, 1985. http://hdl.handle.net/10150/188044.

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α-MSH (α-melanotropin) is a naturally occurring linear tridecapeptide (Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH₂) that is primarily known for its ability to stimulate integumental melanocytes and more recently has been implicated in a variety of physiological and neurological processes. It has been shown that substitution of D-phenylalanine in the seven position of this hormone led to an analogue with increased potency and prolonged biological activity. Furthermore, cyclization between the four and ten positions via a cystine bridge led to analogues with enhanced potency. In t

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46

Thomas, Charles Abidemi Adewale. "Synthetic approaches to anti-hormonal steroids." Thesis, City University London, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.316056.

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47

Lundåsen, Thomas. "Studies on the hormonal regulation of bile acid synthesis /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-053-4/.

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48

Ma, Liying. "Regulatory factors of milk fat synthesis in dairy cows." Diss., Virginia Tech, 2012. http://hdl.handle.net/10919/29120.

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The objective of these studies was to investigate the milk fat synthesis regulation by transcription factors. In the first study, bovine mammary epithelial (MAC-T) cells were treated with sterol regulatory element binding protein-1 (SREBP-1) specific siRNA. The mRNA and protein expression of SREBP-1 were decreased by more than 90% by siRNA. Fatty acid (FA) synthesis, uptake, and selected lipogenic enzyme expression were reduced in cells treated with SREBP-1 siRNA. Therefore, SREBP-1 plays an important role in integrated regulation of lipid synthesis in MAC-T cells through regulation of key enz

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49

Beswick, Naomi Simone. "The influence of recombinant bovine growth hormone and growth hormone releasing factor on fat synthesis in primiparous Holstein cows." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/mq22570.pdf.

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50

Hares, Owen. "Synthetic methodology towards inhibitors of aromatase." Thesis, University of Nottingham, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.278530.

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