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1

Detection and prevention of adverse drug events: Information technologies and human factors. IOS Press, 2009.

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2

Inc, ebrary, ed. Patient safety informatics: Adverse drug events, human factors and IT tools for patient medication safety. IOS Press, 2011.

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3

Sandoval, Henry Carhuatocto. La responsabilidad civil de los hospitales por negligencias médicas y eventos adversos: El caso de las infecciones intrahospitalarias. Jurista, 2010.

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4

Staender, Sven. Managing Adverse Events. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199366149.003.0020.

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The focus of anesthesiologists’ training and activities concerns the management of critically ill patients and the avoidance of catastrophe, rather than management of the aftermath. Anesthesiologists spend years acquiring technical expertise, and there are checklists for dealing with complications. Anesthesiologists have accumulated an immense knowledge in physiology, pathophysiology, and pharmacology, but there is little understanding of how to deal with the overwhelming emotions that occur after a severe complication or adverse event. Death or severe harm to a patient under an anesthesiologi
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5

Boone, Loren J. Adverse Events in Hospitals: Select Studies and Analyses. Nova Science Publishers, Incorporated, 2012.

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6

Halil, Roland B. Prospective identification of hospital adverse drug events using structured pharmacist surveillance. 2003.

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7

Wiffen, Philip, Marc Mitchell, Melanie Snelling, and Nicola Stoner. Adverse drug reactions and drug interactions. Oxford University Press, 2012. http://dx.doi.org/10.1093/med/9780199603640.003.0002.

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Introduction to ADRs 14Classification of ADRs 15Adverse reactions: drug or disease? 16Helping patients understand the risk of ADRs 17Reporting ADRs 18Drug interactions 20Managing drug interactions 23Adverse drug reactions (ADRs), also known as ‘side effects’, ‘adverse drug events’, or ‘drug misadventures’, are a frequent cause of morbidity in hospital and the community. They have a significant cost both financially and in terms of quality of life. Few studies of ADRs have been carried out in the community so the effect on primary care is harder to assess, but studies in the hospital environmen
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8

Ridley, Saxon. Recovering from critical illness in hospital. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0380.

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Recovery from critical illness may not be smooth and uneventful for the patient. Complications and adverse events may beset the patient and lead to intensive care unit (ICU) re-admission. Problems upsetting patients after discharge may be a manifestation of post-intensive care syndrome, new or recurrent organ failure. Avoiding post-ICU complications may be prevented by ensuring a well-planned transition from ICU to the general ward. This may be achieved by minimizing the impact and duration of organ support, defining a structured rehabilitation programme prior to ICU discharge. After discharge
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9

Eyre, Lorna, and Simon Whiteley. In-hospital transfer of the critically ill. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0004.

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While focus has traditionally been on the planning, logistics, and outcome of inter-hospital transfers of the critically-ill patient, attention is turning to in-hospital transfers. Numerically, more in-hospital transfers occur and there is growing evidence that these are associated with a high incidence of adverse events, and increased morbidity and mortality. Appropriate planning, communication, and preparation are essential. Patients should be resuscitated and stabilized (optimized) prior to transfer, to prevent deterioration or instability during transfer. Endotracheal tubes and vascular ac
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10

Hillman, Ken, and Jack Chen. Rapid response teams for the critically ill. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0003.

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There is a high incidence of potentially preventable deaths and serious adverse events in acute hospitals. Most of these events occur on the general wards of the hospital. The concept of rapid response systems was developed as a way of identifying seriously-ill and at-risk patients in acute hospitals at an early stage in order to improve outcomes. The system has two major components—criteria to define the deteriorating patient linked to a rapid response. The criteria are based on a combination of abnormal vital signs and observations, and the response is based on matching the patient with staf
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11

Dargin, James M., and Lillian L. Emlet. Airway Management (DRAFT). Edited by Raghavan Murugan and Joseph M. Darby. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190612474.003.0024.

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Deterioration in respiratory status is the most common reason for activation of rapid response teams (RRT). Severe respiratory failure may necessitate advanced airway management interventions including endotracheal intubation (ETI) in hospital environments that may be especially challenging in clinical context, space, equipment, and personnel. Furthermore, patients undergoing ETI during the course of an RRT event are critically ill, identifying them as patients who are at increased risk for adverse events during the procedure. Many of the challenges of airway management during RRT events can b
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12

Sentinel events in Australia: Public hospitals 2004-05. Australian Institute of Health and Welfare, 2007.

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13

Barnett, Ben J., Lisa Armitige, and Karen J. Vigil. Opportunistic Infections. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190493097.003.0032.

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The question of when to initiate antiretroviral therapy (ART) in the setting of an acute or ongoing opportunistic infection (OI) has been controversial. The immediate initiation of ART in the presence of an OI may provide better clinical outcomes as the immune system improves. However, rapidly decreasing HIV viral load has been associated with the immune reconstitution inflammatory syndrome, which may lead to further complications in the setting of an OI. There are also questions of increasing pill burden, potential drug–drug interactions, additive toxicity and adverse events, and the more pra
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14

Reinecke, Holger. Epidemiology and global burden of peripheral arterial disease and aortic aneurysms. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198784906.003.0068.

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Peripheral artery disease (PAD) and aortic aneurysms are common diseases which show an increasing prevalence and incidence. From community-based trials assessing ankle–brachial indices, 2–4% of the general population have been shown to be affected by PAD, which increases up to 15% in those above 70 years of age. About 30–40% of the in-hospital cases with PAD have critical limb ischaemia and suffer from a 1-year mortality of 20–40%. Abdominal aortic aneurysms (AAAs) also show a relatively high prevalence of about 1–2% in the general population as found by large-scale, systematic duplex screenin
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15

Giuseffi, Jennifer, John McPherson, Chad Wagner, and E. Wesley Ely. Acute cognitive disorders: recognition and management of delirium in the cardiovascular intensive care unit. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199687039.003.0074.

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Delirium is the most common acute cognitive disorder seen in critically ill patients in the cardiovascular intensive care unit. It is defined as a disturbance of consciousness and cognition that develops suddenly and fluctuates over time. Delirious patients can become hyperactive, hypoactive, or both. The occurrence of delirium during hospitalization is associated with increased in-hospital and long-term morbidity and mortality. The cause of delirium is multifactorial and may include imbalances in neurotransmitters, inflammatory mediators, metabolic disturbances, impaired sleep, and the use of
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16

McPherson, John, Jennifer Giuseffi, Chad Wagner, and E. Wesley Ely. Acute cognitive disorders: recognition and management of delirium in the cardiovascular intensive care unit. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199687039.003.0074_update_001.

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Delirium is the most common acute cognitive disorder seen in critically ill patients in the cardiovascular intensive care unit. It is defined as a disturbance of consciousness and cognition that develops suddenly and fluctuates over time. Delirious patients can become hyperactive, hypoactive, or both. The occurrence of delirium during hospitalization is associated with increased in-hospital and long-term morbidity and mortality. The cause of delirium is multifactorial and may include imbalances in neurotransmitters, inflammatory mediators, metabolic disturbances, impaired sleep, and the use of
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