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Journal articles on the topic 'Host and Target'

Author: Grafiati

Published: 4 June 2021

Last updated: 3 February 2022

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1

Toubai, Tomomi, Corinne Rossi, Hiroya Tamaki, et al. "NLRP6 in Host Target Tissues Exacerbates Graft-Versus-Host Disease." Blood 126, no. 23 (2015): 148. http://dx.doi.org/10.1182/blood.v126.23.148.148.

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Abstract Intestinal epithelial cells play an important role in the maintenance of host microbiota as well as intestinal homeostasis by expression of pattern recognition receptors (PRRs). NLRP6 (NOD-like receptor family pyrin domain containing 6) is an important inflammasome component and is highly expressed on the intestinal epithelium and in immune cells. NLRP6 mediated inflammasome activation plays a critical role in intestinal infection and in preventing dysbiosis of gut normal microbiota thorough the secretion of IL-18 and mucus. In addition, NLRP6 knock out (NLRP6-/-) mice show greater se

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2

Toubai, Tomomi, Corinne Rossi, Katherine Oravecz-Wilson, et al. "NLRP6 in Host Target Tissues Exacerbates Graft-Versus-Host-Disease." Biology of Blood and Marrow Transplantation 22, no. 3 (2016): S415—S416. http://dx.doi.org/10.1016/j.bbmt.2015.11.952.

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3

Baillie, J. Kenneth, and Paul Digard. "Influenza — Time to Target the Host?" New England Journal of Medicine 369, no. 2 (2013): 191–93. http://dx.doi.org/10.1056/nejmcibr1304414.

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4

Toubai, Tomomi, Corinne Rossi, Katherine Oravecz-Wilson, et al. "IAPs Protect Host Target Tissues from Graft-Versus-Host Disease (GVHD)." Blood 128, no. 22 (2016): 810. http://dx.doi.org/10.1182/blood.v128.22.810.810.

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Abstract The two Inhibitors of apoptosis proteins (IAPs), X-chromosome-liked linked IAP (XIAP) and cellular IAP1 (cIAP1), inhibit apoptosis and are important in leukemogenesis. Recent data suggest that both xIAP and cIAP play critical, non-overlapping roles in regulating innate and adaptive responses to certain stimuli. But the role of IAPs in allo-immunity is not known. We utilized distinct but complementary approaches, namely genetic and small molecule approaches to determine the role of IAPs in allo-immunity. We first utilized AT-406, a small molecule IAP antagonist that is also known as se

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5

Argilés, J. M., and F. J. López-Soriano. "Host metabolism: a target in clinical oncology?" Medical Hypotheses 51, no. 5 (1998): 411–15. http://dx.doi.org/10.1016/s0306-9877(98)90037-8.

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6

Rocha, Rebeca Froes, Juliana Lemos Del Sarto, Rafael Elias Marques, Vivian Vasconcelos Costa, and Mauro Martins Teixeira. "Host target-based approaches against arboviral diseases." Biological Chemistry 399, no. 3 (2018): 203–17. http://dx.doi.org/10.1515/hsz-2017-0236.

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AbstractIn the 20th century, socioeconomic and environmental changes facilitated the reintroduction of mosquitoes in developing cities, resulting in the reinsertion of mosquito-borne viral diseases and the dispersal of their causative agents on a worldwide scale. Recurrent outbreaks of arboviral diseases are being reported, even in regions without a previous history of arboviral disease transmission. Of note, arboviral infections represented approximately 30% of all emerging vector-borne diseases in the last decade. Therapeutic strategies against infectious viral diseases include the use of di

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7

Chung, Myung-Chul, Shelley C. Jorgensen, Jessica H. Tonry, Fatah Kashanchi, Charles Bailey, and Serguei Popov. "SecretedBacillus anthracisproteases target the host fibrinolytic system." FEMS Immunology & Medical Microbiology 62, no. 2 (2011): 173–81. http://dx.doi.org/10.1111/j.1574-695x.2011.00798.x.

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8

Baseman, J., M. Lange, N. Criscimagna, J. Giron, and C. Thomas. "Interplay between mycoplasmas and host target cells." Microbial Pathogenesis 19, no. 2 (1995): 105–16. http://dx.doi.org/10.1006/mpat.1995.0050.

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9

Toubai, Tomomi, Corinne Rossi, Katherine Oravecz-Wilson, et al. "IAPs protect host target tissues from graft-versus-host disease in mice." Blood Advances 1, no. 19 (2017): 1517–32. http://dx.doi.org/10.1182/bloodadvances.2017004242.

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10

Gardner, Jeffrey, Tze-Hei Yong, Sylvie A. Pitcher, and Michael P. Hoffmann. "Overwintering ofTrichogramma ostriniae(Hymenoptera: Trichogrammatidae) within target and non-target host eggs." Biocontrol Science and Technology 23, no. 4 (2013): 367–80. http://dx.doi.org/10.1080/09583157.2012.761175.

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11

Kaplan, Daniel H., Britt E. Anderson, Jennifer M. McNiff, Dhanpat Jain, Mark J. Shlomchik, and Warren D. Shlomchik. "Target Antigens Determine Graft-versus-Host Disease Phenotype." Journal of Immunology 173, no. 9 (2004): 5467–75. http://dx.doi.org/10.4049/jimmunol.173.9.5467.

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12

Bemmerl, Thomas. "Realtime high level debugging in host/target environments." Microprocessing and Microprogramming 18, no. 1-5 (1986): 387–400. http://dx.doi.org/10.1016/0165-6074(86)90069-4.

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13

Kabiraj, Tarun, and Uday Bhanu Sinha. "Foreign Entry, Acquisition Target and Host Country Welfare." Manchester School 83, no. 6 (2014): 725–48. http://dx.doi.org/10.1111/manc.12084.

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14

Fällman, M., C. Persson, and H. Wolf-Watz. "Yersinia proteins that target host cell signaling pathways." Journal of Clinical Investigation 99, no. 6 (1997): 1153–57. http://dx.doi.org/10.1172/jci119270.

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15

Wei, Hua, and Ming-Ming Zhou. "Viral-encoded enzymes that target host chromatin functions." Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1799, no. 3-4 (2010): 296–301. http://dx.doi.org/10.1016/j.bbagrm.2009.08.007.

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16

DeBoy, Robert T., and Nancy L. Craig. "Target Site Selection by Tn7:attTn7 Transcription and Target Activity." Journal of Bacteriology 182, no. 11 (2000): 3310–13. http://dx.doi.org/10.1128/jb.182.11.3310-3313.2000.

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ABSTRACT The bacterial transposon Tn7 inserts at high frequency into a specific site called attTn7, which is present in the chromosomes of many bacteria. We show here that transcription of a nearby gene, glmS, decreases the frequency of Tn7 insertion intoattTn7, thus providing a link between Tn7 transposition and host cell metabolism.

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17

Martin, Alexander J., та David A. Jans. "Antivirals that target the host IMPα/β1-virus interface". Biochemical Society Transactions 49, № 1 (2021): 281–95. http://dx.doi.org/10.1042/bst20200568.

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Although transport into the nucleus mediated by the importin (IMP) α/β1-heterodimer is central to viral infection, small molecule inhibitors of IMPα/β1-dependent nuclear import have only been described and shown to have antiviral activity in the last decade. Their robust antiviral activity is due to the strong reliance of many different viruses, including RNA viruses such as human immunodeficiency virus-1 (HIV-1), dengue (DENV), and Zika (ZIKV), on the IMPα/β1-virus interface. High-throughput compound screens have identified many agents that specifically target this interface. Of these, agents

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18

Rub, Abdur, Mohd Arish, Syed Akhtar Husain, Niyaz Ahmed, and Yusuf Akhter. "Host-lipidome as a potential target of protozoan parasites." Microbes and Infection 15, no. 10-11 (2013): 649–60. http://dx.doi.org/10.1016/j.micinf.2013.06.006.

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19

Gennarino, V. A., M. Sardiello, R. Avellino, et al. "MicroRNA target prediction by expression analysis of host genes." Genome Research 19, no. 3 (2008): 481–90. http://dx.doi.org/10.1101/gr.084129.108.

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20

Guo, Yang Eric, Theresa Oei, and Joan A. Steitz. "Herpesvirus saimiri MicroRNAs Preferentially Target Host Cell Cycle Regulators." Journal of Virology 89, no. 21 (2015): 10901–11. http://dx.doi.org/10.1128/jvi.01884-15.

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ABSTRACTIn latently infected marmoset T cells,Herpesvirus saimiri(HVS) expresses six microRNAs (known as miR-HSURs [H. saimiriU-rich RNAs]). The viral miR-HSURs are processed from chimeric primary transcripts, each containing a noncoding U-rich RNA (HSUR) and a pre-miRNA hairpin. To uncover the functions of miR-HSURs, we identified mRNA targets in infected cells using high-throughput sequencing of RNA isolated by cross-linking immunoprecipitation (HITS-CLIP). HITS-CLIP revealed hundreds of robust Argonaute (Ago) binding sites mediated by miR-HSURs that map to the host genome but few in the HVS

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21

Basha, S., P. Rai, V. Poon, et al. "Polyvalent inhibitors of anthrax toxin that target host receptors." Proceedings of the National Academy of Sciences 103, no. 36 (2006): 13509–13. http://dx.doi.org/10.1073/pnas.0509870103.

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22

Harrison, M. D. "Monitoring a target network to support subsequent host simulation." Journal of Microcomputer Applications 8, no. 1 (1985): 75–85. http://dx.doi.org/10.1016/0745-7138(85)90028-4.

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23

Hirabara, Sandro Massao, Renata Gorjao, Adriana Cristina Levada-Pires, et al. "Host cell glutamine metabolism as a potential antiviral target." Clinical Science 135, no. 2 (2021): 305–25. http://dx.doi.org/10.1042/cs20201042.

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Abstract A virus minimally contains a nucleic acid genome packaged by a protein coat. The genome and capsid together are known as the nucleocapsid, which has an envelope containing a lipid bilayer (mainly phospholipids) originating from host cell membranes. The viral envelope has transmembrane proteins that are usually glycoproteins. The proteins in the envelope bind to host cell receptors, promoting membrane fusion and viral entry into the cell. Virus-infected host cells exhibit marked increases in glutamine utilization and metabolism. Glutamine metabolism generates ATP and precursors for the

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24

Croitoru, David O., and Vincent Piguet. "Identifying a Potential Therapeutic Host Target in Cutaneous Leishmaniasis." Journal of Investigative Dermatology 141, no. 3 (2021): 474–76. http://dx.doi.org/10.1016/j.jid.2020.08.033.

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25

Luo, Tian, Jeeba A. Kuriakose, Bing Zhu, Abdul Wakeel, and Jere W. McBride. "Ehrlichia chaffeensis TRP120 Interacts with a Diverse Array of Eukaryotic Proteins Involved in Transcription, Signaling, and Cytoskeleton Organization." Infection and Immunity 79, no. 11 (2011): 4382–91. http://dx.doi.org/10.1128/iai.05608-11.

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ABSTRACTEhrlichia chaffeensisis an obligately intracellular bacterium that exhibits tropism for mononuclear phagocytes and survives by evading host cell defense mechanisms. Recently, molecular interactions betweenE. chaffeensis47-kDa tandem repeat (TR) protein (TRP47) and the eukaryotic host cell have been described. In this investigation, yeast (Saccharomyces cerevisiae) two-hybrid analysis demonstrated thatE. chaffeensis-secreted tandem repeat protein 120 (TRP120) interacts with a diverse group of host cell proteins associated with major biological processes, including transcription and regu

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26

Jagdeo, Julienne M., Antoine Dufour, Theo Klein, et al. "N-Terminomics TAILS Identifies Host Cell Substrates of Poliovirus and Coxsackievirus B3 3C Proteinases That Modulate Virus Infection." Journal of Virology 92, no. 8 (2018): e02211-17. http://dx.doi.org/10.1128/jvi.02211-17.

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ABSTRACTEnteroviruses encode proteinases that are essential for processing of the translated viral polyprotein. In addition, viral proteinases also target host proteins to manipulate cellular processes and evade innate antiviral responses to promote replication and infection. Although some host protein substrates of enterovirus proteinases have been identified, the full repertoire of targets remains unknown. We used a novel quantitativein vitroproteomics-based approach, termedterminalamineisotopiclabeling ofsubstrates (TAILS), to identify with high confidence 72 and 34 new host protein targets

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27

Blakeslee, AMH, RB Barnard, K. Matheson, and CH McKenzie. "Host-switching among crabs: species introduction results in a new target host for native parasites." Marine Ecology Progress Series 636 (February 20, 2020): 91–106. http://dx.doi.org/10.3354/meps13214.

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Invasive species can introduce parasites to, and/or acquire new parasites from, novel regions, thereby greatly influencing community interactions, including symbiotic relationships involving parasites. Host-switching of native and non-native parasites could enhance or dilute parasite transmission and spread among hosts. We investigated the effect of host invasion on trematode parasitism in 2 Newfoundland (Canada) bays: one invaded by European green crabs Carcinus maenas and the other not yet invaded. To determine the influence of C. maenas on host-parasite relationships, we assessed trematode

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28

NORMAN, R., and R. G. BOWERS. "A Host-Host-Pathogen Model with Vaccination and its Application to Target and Reservoir Hosts." Mathematical Population Studies 14, no. 1 (2007): 31–56. http://dx.doi.org/10.1080/08898480601090667.

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29

Meng, Qingren, Yanan Chu, Changjun Shao, et al. "Roles of host small RNAs in the evolution and host tropism of coronaviruses." Briefings in Bioinformatics 22, no. 2 (2021): 1096–105. http://dx.doi.org/10.1093/bib/bbab027.

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Abstract Human coronaviruses (CoVs) can cause respiratory infection epidemics that sometimes expand into globally relevant pandemics. All human CoVs have sister strains isolated from animal hosts and seem to have an animal origin, yet the process of host jumping is largely unknown. RNA interference (RNAi) is an ancient mechanism in many eukaryotes to defend against viral infections through the hybridization of host endogenous small RNAs (miRNAs) with target sites in invading RNAs. Here, we developed a method to identify potential RNAi-sensitive sites in the viral genome and discovered that hum

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30

Chatterjee, Bhaswati, and Suman S. Thakur. "ACE2 as a potential therapeutic target for pandemic COVID-19." RSC Advances 10, no. 65 (2020): 39808–13. http://dx.doi.org/10.1039/d0ra08228g.

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31

Wang, Yafei, Zhisong Zhou, Chongfeng Wei, Yahui Liu, and Chengliang Yin. "Host–Target Vehicle Model-Based Lateral State Estimation for Preceding Target Vehicles Considering Measurement Delay." IEEE Transactions on Industrial Informatics 14, no. 9 (2018): 4190–99. http://dx.doi.org/10.1109/tii.2018.2828125.

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32

Zhang, Li, Jian Yao, John Withers, et al. "Host target modification as a strategy to counter pathogen hijacking of the jasmonate hormone receptor." Proceedings of the National Academy of Sciences 112, no. 46 (2015): 14354–59. http://dx.doi.org/10.1073/pnas.1510745112.

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In the past decade, characterization of the host targets of pathogen virulence factors took a center stage in the study of pathogenesis and disease susceptibility in plants and humans. However, the impressive knowledge of host targets has not been broadly exploited to inhibit pathogen infection. Here, we show that host target modification could be a promising new approach to “protect” the disease-vulnerable components of plants. In particular, recent studies have identified the plant hormone jasmonate (JA) receptor as one of the common targets of virulence factors from highly evolved biotrophi

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33

Haye, T., U. Kuhlmann, H. Goulet, and P. G. Mason. "ControllingLygusplant bugs (Heteroptera: Miridae) with EuropeanPeristenus relictus(Hymenoptera: Braconidae) in Canada – risky or not?" Bulletin of Entomological Research 96, no. 2 (2006): 187–96. http://dx.doi.org/10.1079/ber2005414.

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AbstractThe EuropeanPeristenus relictusLoan (syn.P. stygicus) has been considered for biological control ofLygusplant bugs native to Canada. Laboratory and field studies were conducted in the area of origin to evaluate the host specificity ofP. relictus. Laboratory choice and no-choice tests demonstrated thatP. relictusattacked all non-target species offered (fundamental host range). However, closely related non-target mirids (tribe Mirini) were generally well accepted byP. relictus, while hosts from the tribe Stenodemini were less frequently attacked and less suitable for parasitoid developme

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34

Thomas, D. D., J. B. Baseman, and J. F. Alderete. "Fibronectin tetrapeptide is target for syphilis spirochete cytadherence." Journal of Experimental Medicine 162, no. 5 (1985): 1715–19. http://dx.doi.org/10.1084/jem.162.5.1715.

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The syphilis bacterium, Treponema pallidum, parasitizes host cells through recognition of fibronectin (Fn) on cell surfaces. The active site of the Fn molecule has been identified as a four-amino acid sequence, arg-gly-asp-ser (RGDS), located on each monomer of the cell-binding domain. The synthetic heptapeptide gly-arg-gly-asp-ser-pro-cys (GRGDSPC), with the active site sequence RGDS, specifically competed with 125I-labeled cell-binding domain acquisition by T. pallidum. Additionally, the same heptapeptide with the RGDS sequence diminished treponemal attachment to HEp-2 and HT1080 cell monola

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35

Greene, John P., Matthew Gott, Richard L. Fink, and Igor Pavlovsky. "Rhenium and iridium targets prepared using a novel graphene loading technique." EPJ Web of Conferences 229 (2020): 06001. http://dx.doi.org/10.1051/epjconf/202022906001.

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For accelerator targets, graphene films are an excellent material choice due to their high thermal conductivity, high temperature tolerance, low outgassing, mechanical integrity, and ease of handling. A variety of targets have been produced using graphene material as a backing or a host matrix. One of the unique advantages of the graphene film fabrication process is the capability to embed target materials, including refractory metals, in the nanoparticle form into a host graphene matrix during target preparation. Targets of natIr and natRe have been fabricated as nanoparticle loaded graphene

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36

Rotolo, Jimmy A., Branka Stancevic, Sydney X. Lu, et al. "Cytolytic T cells induce ceramide-rich platforms in target cell membranes to initiate graft-versus-host disease." Blood 114, no. 17 (2009): 3693–706. http://dx.doi.org/10.1182/blood-2008-11-191148.

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Abstract Alloreactive donor cytolytic T lymphocytes play a critical role in pathophysiology of acute graft-versus-host disease (GVHD). As GVHD progression involves tumor necrosis factor superfamily receptor activation, and as apoptotic signaling for some tumor necrosis factor superfamily receptors might involve acid sphingomyelinase (ASMase)–mediated ceramide generation, we hypothesized that ASMase deletion would ameliorate GVHD. Using clinically relevant mouse models of acute GVHD in which allogeneic bone marrow and T cells were transplanted into asmase+/+ and asmase−/− hosts, we identify hos

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37

Monk, Chandler H., and Kevin J. Zwezdaryk. "Host Mitochondrial Requirements of Cytomegalovirus Replication." Current Clinical Microbiology Reports 7, no. 4 (2020): 115–23. http://dx.doi.org/10.1007/s40588-020-00153-5.

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Abstract Purpose of Review Metabolic rewiring of the host cell is required for optimal viral replication. Human cytomegalovirus (HCMV) has been observed to manipulate numerous mitochondrial functions. In this review, we describe the strategies and targets HCMV uses to control different aspects of mitochondrial function. Recent Findings The mitochondria are instrumental in meeting the biosynthetic and bioenergetic needs of HCMV replication. This is achieved through altered metabolism and signaling pathways. Morphological changes mediated through biogenesis and fission/fusion dynamics contribute

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38

Council, Olivia D., and Sarah B. Joseph. "Evolution of Host Target Cell Specificity During HIV-1 Infection." Current HIV Research 16, no. 1 (2018): 13–20. http://dx.doi.org/10.2174/1570162x16666171222105721.

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Background: Many details of HIV-1 molecular virology have been translated into lifesaving antiviral drugs. Yet, we have an incomplete understanding of the cells in which HIV-1 replicates in untreated individuals and persists in during antiretroviral therapy.Methods: In this review we discuss how viral entry phenotypes have been characterized and the insights they have revealed about the target cells supporting HIV-1 replication. In addition, we will examine whether some HIV-1 variants have the ability to enter cells lacking CD4 (such as astrocytes) and the role that trans-infection plays in HI

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39

Böhme, Linda, and Thomas Rudel. "Host cell death machinery as a target for bacterial pathogens." Microbes and Infection 11, no. 13 (2009): 1063–70. http://dx.doi.org/10.1016/j.micinf.2009.08.014.

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40

Wang, Xia, Yijun Lou, and Xinyu Song. "Age-Structured Within-Host HIV Dynamics with Multiple Target Cells." Studies in Applied Mathematics 138, no. 1 (2016): 43–76. http://dx.doi.org/10.1111/sapm.12135.

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41

Zenonos, Zenon A., Sara K. Dummler, Nicole Müller-Sienerth, et al. "Basigin is a druggable target for host-oriented antimalarial interventions." Journal of Experimental Medicine 212, no. 8 (2015): 1145–51. http://dx.doi.org/10.1084/jem.20150032.

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Plasmodium falciparum is the parasite responsible for the most lethal form of malaria, an infectious disease that causes a large proportion of childhood deaths and poses a significant barrier to socioeconomic development in many countries. Although antimalarial drugs exist, the repeated emergence and spread of drug-resistant parasites limit their useful lifespan. An alternative strategy that could limit the evolution of drug-resistant parasites is to target host factors that are essential and universally required for parasite growth. Host-targeted therapeutics have been successfully applied in

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42

Klebl, Bert M., and Axel Choidas. "CDK9/cyclin T1: a host cell target for antiretroviral therapy." Future Virology 1, no. 3 (2006): 317–30. http://dx.doi.org/10.2217/17460794.1.3.317.

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43

Fujii, Masako. "Long distance transplant-to-host axon elongation without target deafferentation." NeuroReport 5, no. 2 (1993): 161–64. http://dx.doi.org/10.1097/00001756-199311180-00017.

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44

Tardy, J. E. "Host/target approach to embedded system development is becoming obsolete." ACM SIGSOFT Software Engineering Notes 13, no. 4 (1988): 45–51. http://dx.doi.org/10.1145/58418.58421.

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45

Charles, J. G., and J. S. Dugdale. "Non-target species selection for host-range testing ofMastrus ridens." New Zealand Entomologist 34, no. 1 (2011): 45–51. http://dx.doi.org/10.1080/00779962.2011.9722208.

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46

Ikeda, Masanori, and Nobuyuki Kato. "Modulation of host metabolism as a target of new antivirals." Advanced Drug Delivery Reviews 59, no. 12 (2007): 1277–89. http://dx.doi.org/10.1016/j.addr.2007.03.021.

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47

Ferracini, Chiara, Ester Ferrari, Matteo Alessandro Saladini, Marianna Pontini, Marida Corradetti, and Alberto Alma. "Non-target host risk assessment for the parasitoid Torymus sinensis." BioControl 60, no. 5 (2015): 583–94. http://dx.doi.org/10.1007/s10526-015-9676-1.

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48

Scalley-Kim, Michelle, Audrey McConnell-Smith, and Barry L. Stoddard. "Coevolution of a Homing Endonuclease and Its Host Target Sequence." Journal of Molecular Biology 372, no. 5 (2007): 1305–19. http://dx.doi.org/10.1016/j.jmb.2007.07.052.

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49

Tichelli, André, and Alois Gratwohl. "Vascular endothelium as ‘novel’ target of graft-versus-host disease." Best Practice & Research Clinical Haematology 21, no. 2 (2008): 139–48. http://dx.doi.org/10.1016/j.beha.2008.02.002.

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50

Kamau, Edwin T., Ananth R. Srinivasan, Mark J. Brown, Matthew G. Fair, Erin J. Caraher, and Jon P. Boyle. "A Focused Small-Molecule Screen Identifies 14 Compounds with Distinct Effects on Toxoplasma gondii." Antimicrobial Agents and Chemotherapy 56, no. 11 (2012): 5581–90. http://dx.doi.org/10.1128/aac.00868-12.

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ABSTRACTToxoplasma gondiiis a globally ubiquitous pathogen that can cause severe disease in immunocompromised humans and the developing fetus. Given the proven role ofToxoplasma-secreted kinases in the interaction ofToxoplasmawith its host cell, identification of novel kinase inhibitors could precipitate the development of new anti-Toxoplasmadrugs and define new pathways important for parasite survival. We selected a small (n= 527) but diverse set of putative kinase inhibitors and screened them for effects on the growth ofToxoplasmain vitro. We identified and validated 14 noncytotoxic compound

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