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Journal articles on the topic 'Host dependency factors'

Author: Grafiati

Published: 19 October 2024

Last updated: 31 July 2025

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1

Hamm, Joshua N., Susanne Erdmann, Emiley A. Eloe-Fadrosh, et al. "Unexpected host dependency of Antarctic Nanohaloarchaeota." Proceedings of the National Academy of Sciences 116, no. 29 (2019): 14661–70. http://dx.doi.org/10.1073/pnas.1905179116.

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In hypersaline environments, Nanohaloarchaeota (Diapherotrites, Parvarchaeota, Aenigmarchaeota, Nanoarchaeota, Nanohaloarchaeota [DPANN] superphylum) are thought to be free-living microorganisms. We report cultivation of 2 strains of Antarctic Nanohaloarchaeota and show that they require the haloarchaeon Halorubrum lacusprofundi for growth. By performing growth using enrichments and fluorescence-activated cell sorting, we demonstrated successful cultivation of Candidatus Nanohaloarchaeum antarcticus, purification of Ca. Nha. antarcticus away from other species, and growth and verification of C

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Verrier, Eloi R., Amélie Weiss, Charlotte Bach, et al. "Combined small molecule and loss-of-function screen uncovers estrogen receptor alpha and CAD as host factors for HDV infection and antiviral targets." Gut 69, no. 1 (2019): 158–67. http://dx.doi.org/10.1136/gutjnl-2018-317065.

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ObjectiveHepatitis D virus (HDV) is a circular RNA virus coinfecting hepatocytes with hepatitis B virus. Chronic hepatitis D results in severe liver disease and an increased risk of liver cancer. Efficient therapeutic approaches against HDV are absent.DesignHere, we combined an RNAi loss-of-function and small molecule screen to uncover host-dependency factors for HDV infection.ResultsFunctional screening unravelled the hypoxia-inducible factor (HIF)-signalling and insulin-resistance pathways, RNA polymerase II, glycosaminoglycan biosynthesis and the pyrimidine metabolism as virus-hepatocyte de

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Kanojia, Aditi, Mansi Sharma, Rishad Shiraz, and Shashank Tripathi. "Flavivirus–Host Interaction Landscape Visualized through Genome-Wide CRISPR Screens." Viruses 14, no. 10 (2022): 2164. http://dx.doi.org/10.3390/v14102164.

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Flaviviruses comprise several important human pathogens which cause significant morbidity and mortality worldwide. Like any other virus, they are obligate intracellular parasites. Therefore, studying the host cellular factors that promote or restrict their replication and pathogenesis becomes vital. Since inhibiting the host dependency factors or activating the host restriction factors can suppress the viral replication and propagation in the cell, identifying them reveals potential targets for antiviral therapeutics. Clustered regularly interspaced short palindromic repeats (CRISPR) technolog

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Becker, Tanja, Vu Le-Trilling, and Mirko Trilling. "Cellular Cullin RING Ubiquitin Ligases: Druggable Host Dependency Factors of Cytomegaloviruses." International Journal of Molecular Sciences 20, no. 7 (2019): 1636. http://dx.doi.org/10.3390/ijms20071636.

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Human cytomegalovirus (HCMV) is a ubiquitous betaherpesvirus that frequently causes morbidity and mortality in individuals with insufficient immunity, such as transplant recipients, AIDS patients, and congenitally infected newborns. Several antiviral drugs are approved to treat HCMV infections. However, resistant HCMV mutants can arise in patients receiving long-term therapy. Additionally, side effects and the risk to cause birth defects limit the use of currently approved antivirals against HCMV. Therefore, the identification of new drug targets is of clinical relevance. Recent work identifie

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Aromolaran, Olufemi, Thomas Beder, Eunice Adedeji, et al. "Predicting host dependency factors of pathogens in Drosophila melanogaster using machine learning." Computational and Structural Biotechnology Journal 19 (2021): 4581–92. http://dx.doi.org/10.1016/j.csbj.2021.08.010.

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Petrova, Evgeniya, Ségolène Gracias, Guillaume Beauclair, Frédéric Tangy, and Nolwenn Jouvenet. "Uncovering Flavivirus Host Dependency Factors through a Genome-Wide Gain-of-Function Screen." Viruses 11, no. 1 (2019): 68. http://dx.doi.org/10.3390/v11010068.

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Flaviviruses, such as dengue (DENV), West Nile (WNV), yellow fever (YFV) and Zika (ZIKV) viruses, are mosquito-borne pathogens that present a major risk to global public health. To identify host factors that promote flavivirus replication, we performed a genome-wide gain-of-function cDNA screen for human genes that enhance the replication of flavivirus reporter particles in human cells. The screen recovered seventeen potential host proteins that promote viral replication, including the previously known dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit (DDOST)

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Syarifuddin, Ferry. "The Dynamics of Foreign Portfolio Investment and Exchange Rates: An Interconnection Approach in ASEAN." Journal of Eurasian Economies 1, no. 2 (2022): 1–12. http://dx.doi.org/10.36880/j01.2.0113.

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This paper examines the spatial dependence of foreign portfolio investment (FPI) inflows among ASEAN countries in 2002Q1-2018Q4 utilizing the spatial econometric approach. This paper adds clarity to the identification of the true nature of portfolio investment performances. I show a competitive relationship among ASEAN countries, indicating crowding out of FPI in the host country is most likely to occur when the neighboring country is experiencing a crowding out. I also show that exchange rate volatility and changes, both in the host country and neighboring country, do not significantly affect

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8

Roesmann, Fabian, Lisa Müller, Katleen Klaassen, Stefanie Heß, and Marek Widera. "Interferon-Regulated Expression of Cellular Splicing Factors Modulates Multiple Levels of HIV-1 Gene Expression and Replication." Viruses 16, no. 6 (2024): 938. http://dx.doi.org/10.3390/v16060938.

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Type I interferons (IFN-Is) are pivotal in innate immunity against human immunodeficiency virus I (HIV-1) by eliciting the expression of IFN-stimulated genes (ISGs), which encompass potent host restriction factors. While ISGs restrict the viral replication within the host cell by targeting various stages of the viral life cycle, the lesser-known IFN-repressed genes (IRepGs), including RNA-binding proteins (RBPs), affect the viral replication by altering the expression of the host dependency factors that are essential for efficient HIV-1 gene expression. Both the host restriction and dependency

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9

Rother, Marion, Christiane Dimmler, Friderike Weege, Hans-Joachim Mollenkopf, Thomas F. Meyer, and Michael Naumann. "Discovery of Zika virus host dependency factors in trophoblasts using CRISPR/Cas9 screening." Journal of Virological Methods 290 (April 2021): 114085. http://dx.doi.org/10.1016/j.jviromet.2021.114085.

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10

King, Cason R., and Andrew Mehle. "The later stages of viral infection: An undiscovered country of host dependency factors." PLOS Pathogens 16, no. 8 (2020): e1008777. http://dx.doi.org/10.1371/journal.ppat.1008777.

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11

Ma, Yijie, Michael J. Walsh, Katharina Bernhardt, et al. "CRISPR/Cas9 Screens Reveal Epstein-Barr Virus-Transformed B Cell Host Dependency Factors." Cell Host & Microbe 21, no. 5 (2017): 580–91. http://dx.doi.org/10.1016/j.chom.2017.04.005.

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12

Park, Ryan J., Tim Wang, Dylan Koundakjian, et al. "A genome-wide CRISPR screen identifies a restricted set of HIV host dependency factors." Nature Genetics 49, no. 2 (2016): 193–203. http://dx.doi.org/10.1038/ng.3741.

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13

Zhang, Xi, Hin Chu, Lei Wen, et al. "Competing endogenous RNA network profiling reveals novel host dependency factors required for MERS-CoV propagation." Emerging Microbes & Infections 9, no. 1 (2020): 733–46. http://dx.doi.org/10.1080/22221751.2020.1738277.

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14

Hafer, Terry L., Abby Felton, Yennifer Delgado, Harini Srinivasan, and Michael Emerman. "A CRISPR Screen of HIV Dependency Factors Reveals That CCNT1 Is Non-Essential in T Cells but Required for HIV-1 Reactivation from Latency." Viruses 15, no. 9 (2023): 1863. http://dx.doi.org/10.3390/v15091863.

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We sought to explore the hypothesis that host factors required for HIV-1 replication also play a role in latency reversal. Using a CRISPR gene library of putative HIV dependency factors, we performed a screen to identify genes required for latency reactivation. We identified several HIV-1 dependency factors that play a key role in HIV-1 latency reactivation including ELL, UBE2M, TBL1XR1, HDAC3, AMBRA1, and ALYREF. The knockout of Cyclin T1 (CCNT1), a component of the P-TEFb complex that is important for transcription elongation, was the top hit in the screen and had the largest effect on HIV l

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Diana, Uwaila Oboite. "Perceived impact of volunteer tourism on host communities in Lubbock, United States: A qualitative exploration." World Journal of Advanced Research and Reviews 23, no. 2 (2024): 1501–14. https://doi.org/10.5281/zenodo.14859534.

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Volunteer tourism is a popular trend with millions of people participating in various volunteer activities. Although volunteer tourism is frequently promoted as a way to improve host communities, little is known about how it is perceived to impact host communities. Hence this study explored the perceptions of volunteer tourists regarding the impact of their activities on the host community; investigated the alignment between volunteer tourists’ perceptions of impact and the actual needs and concerns of the host community; gathered insights into the factors influencing volunteer tourists&

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16

Hafirassou, Mohamed Lamine, Laurent Meertens, Claudia Umaña-Diaz, et al. "A Global Interactome Map of the Dengue Virus NS1 Identifies Virus Restriction and Dependency Host Factors." Cell Reports 21, no. 13 (2017): 3900–3913. http://dx.doi.org/10.1016/j.celrep.2017.11.094.

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Hafirassou, Mohamed Lamine, Laurent Meertens, Claudia Umaña-Diaz, et al. "A Global Interactome Map of the Dengue Virus NS1 Identifies Virus Restriction and Dependency Host Factors." Cell Reports 22, no. 5 (2018): 1364. http://dx.doi.org/10.1016/j.celrep.2018.01.038.

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18

Aldamen, Yasmin. "Understanding Social Media Dependency, and Uses and Gratifications as a Communication System in the Migration Era: Syrian Refugees in Host Countries as a Case Study." Social Sciences 12, no. 6 (2023): 322. http://dx.doi.org/10.3390/socsci12060322.

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Through the theoretical frameworks of the media system dependency model and uses and gratifications theory, this study examined the uses of social media by Syrian refugees in Jordan and Turkey. A mixed-methods approach was used to increase the credibility and validity of the study’s findings by combining a qualitative method with quantitative data. The findings show that there were some factors that affected the Syrian refugees’ use of social media before seeking refuge in Jordan and Turkey, which were mainly its ban due to the regime’s censorship and a bad Internet connection due to the bad i

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19

Mosbah, Aissa, Jaithen Alharbi, Abdulla Fetais, and Ibrahim Alkandi. "The Role of the Manager in the Middle East: An Empirical Study of Multinational Companies." Global Business Review 20, no. 4 (2019): 887–900. http://dx.doi.org/10.1177/0972150919844892.

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This article is an empirical investigation into the role of the CEO manager in the affiliates of multinational corporations operating in the Middle East. Grounded in a literature review of the reasons for employing either parent country nationals (PCNs) or host country nationals (HCNs) in top management position in foreign subsidiaries, a number of factors influencing the choice between these alternatives are identified. Using a data collected from 147 multinational companies (MNCs) operating in the Kingdom of Saudi Arabia (KSA), the influence of each of these factors on this selection is empi

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Kratzel, Annika, Jenna N. Kelly, Philip V’kovski, et al. "A genome-wide CRISPR screen identifies interactors of the autophagy pathway as conserved coronavirus targets." PLOS Biology 19, no. 12 (2021): e3001490. http://dx.doi.org/10.1371/journal.pbio.3001490.

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Over the past 20 years, 3 highly pathogenic human coronaviruses (HCoVs) have emerged—Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV), Middle East Respiratory Syndrome Coronavirus (MERS-CoV), and, most recently, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)—demonstrating that coronaviruses (CoVs) pose a serious threat to human health and highlighting the importance of developing effective therapies against them. Similar to other viruses, CoVs are dependent on host factors for their survival and replication. We hypothesized that evolutionarily distinct CoVs may exploit si

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Yin, Xin, Yuan Pu, Shuofeng Yuan, et al. "Global siRNA screen identifies human host factors critical for SARS-CoV-2 replication and late stages of infection." PLOS Biology 23, no. 6 (2025): e3002738. https://doi.org/10.1371/journal.pbio.3002738.

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Defining the subset of cellular factors governing SARS-CoV-2 replication can provide critical insights into viral pathogenesis and identify targets for host-directed antiviral therapies. While a number of genetic screens have previously reported SARS-CoV-2 host dependency factors, most of these approaches relied on utilizing pooled genome-scale CRISPR libraries, which are biased toward the discovery of host proteins impacting early stages of viral replication. To identify host factors involved throughout the SARS-CoV-2 infectious cycle, we conducted an arrayed genome-scale siRNA screen. Result

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Diana Uwaila Oboite. "Perceived impact of volunteer tourism on host communities in Lubbock, United States: A qualitative exploration." World Journal of Advanced Research and Reviews 23, no. 2 (2024): 1501–14. http://dx.doi.org/10.30574/wjarr.2024.23.2.2445.

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Volunteer tourism is a popular trend with millions of people participating in various volunteer activities. Although volunteer tourism is frequently promoted as a way to improve host communities, little is known about how it is perceived to impact host communities. Hence this study explored the perceptions of volunteer tourists regarding the impact of their activities on the host community; investigated the alignment between volunteer tourists’ perceptions of impact and the actual needs and concerns of the host community; gathered insights into the factors influencing volunteer tourists’ perce

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23

Long, Xueyan, Gexin Liu, Xinyi Liu, Chunlin Zhang, Lei Shi, and Zhenglin Zhu. "Identifying the HIV-Resistance-Related Factors and Regulatory Network via Multi-Omics Analyses." International Journal of Molecular Sciences 25, no. 21 (2024): 11757. http://dx.doi.org/10.3390/ijms252111757.

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For research on HIV/AIDS, it is important to elucidate the complex viral–host interaction, host dependency factors (HDFs), and restriction factors. However, the regulatory network of HIV-resistance-related factors remains not well understood. Therefore, we integrated four publicly available HIV-related transcriptome datasets, along with three datasets on HIV-infection-related DNA methylation, miRNA, and ChIP-seq, to predict the factors influencing HIV resistance and infection. Our approach involved differential analysis, functional annotation, and protein–protein interaction network analysis.

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Kokkonos, Konstantinos G., Nicolas Fossat, Louise Nielsen, et al. "Evolutionary selection of pestivirus variants with altered or no microRNA dependency." Nucleic Acids Research 48, no. 10 (2020): 5555–71. http://dx.doi.org/10.1093/nar/gkaa300.

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Abstract Host microRNA (miRNA) dependency is a hallmark of the human pathogen hepatitis C virus (HCV) and was also described for the related pestiviruses, which are important livestock pathogens. The liver-specific miR-122 binds within the HCV 5′ untranslated region (UTR), whereas the broadly expressed let-7 and miR-17 families bind two sites (S1 and S2, respectively) in the pestiviral 3′ UTR. Here, we dissected the mechanism of miRNA dependency of the pestivirus bovine viral diarrhea virus (BVDV). Argonaute 2 (AGO2) and miR-17 binding were essential for viral replication, whereas let-7 bindin

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Schmidt, Nora, and Mathias Munschauer. "Atlas der SARS-CoV-2-RNA-Protein-Interaktionen in infizierten Zellen." BIOspektrum 27, no. 4 (2021): 376–79. http://dx.doi.org/10.1007/s12268-021-1587-3.

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AbstractUsing RNA antisense purification and mass spectrometry, we identified more than 100 human proteins that directly and specifically bind SARS-CoV-2 RNA in infected cells. To gain insights into the functions of selected RNA interactors, we applied genetic perturbation and pharmacological inhibition experiments, and mapped the contact sites on the viral RNA. This led to the identification of host dependency factors and defense strategies, which can guide the design of novel therapeutics against SARS-CoV-2.

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Bao, Yanqing, Lin Wang, and Jianjun Sun. "A Small Protein but with Diverse Roles: A Review of EsxA in Mycobacterium–Host Interaction." Cells 10, no. 7 (2021): 1645. http://dx.doi.org/10.3390/cells10071645.

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As a major effector of the ESX-1 secretion system, EsxA is essential for the virulence of pathogenic mycobacteria, such as Mycobacterium tuberculosis (Mtb) and Mycobacterium marinum (Mm). EsxA possesses an acidic pH-dependent membrane permeabilizing activity and plays an essential role by mediating mycobacterial escape from the phagosome and translocation to the cytosol for intracellular replication. Moreover, EsxA regulates host immune responses as a potent T-cell antigen and a strong immunoregulator. EsxA interacts with multiple cellular proteins and stimulates several signal pathways, such

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Abdulahi, Kader Ahmed. "Social Cohesion Between Internally Displaced People and Host Communities in Somali Region of Ethiopia: The Case of Qolaji Camp." Journal of Arts, Humanities and Social Science 2, no. 2 (2025): 78–86. https://doi.org/10.69739/jahss.v2i2.592.

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In the Qoloji settlement in the Somali region of Ethiopia, this study examines the social cohesion between the host community and internally displaced people (IDPs). The study uses a mixed-methods descriptive approach that includes two focus groups, nine interviews, and a survey with 156 respondents. Three factors are used to quantify social cohesion: cooperation, feeling of identity, and trust. With mean scores of 4.1 for cooperation and trust and 4.3 for sense of belonging, the results show strong levels of social cohesion. Qualitative data emphasizes how crucial shared cultural components—l

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Chai, Haiting, Quan Gu, Joseph Hughes, and David L. Robertson. "In silico prediction of HIV-1-host molecular interactions and their directionality." PLOS Computational Biology 18, no. 2 (2022): e1009720. http://dx.doi.org/10.1371/journal.pcbi.1009720.

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Human immunodeficiency virus type 1 (HIV-1) continues to be a major cause of disease and premature death. As with all viruses, HIV-1 exploits a host cell to replicate. Improving our understanding of the molecular interactions between virus and human host proteins is crucial for a mechanistic understanding of virus biology, infection and host antiviral activities. This knowledge will potentially permit the identification of host molecules for targeting by drugs with antiviral properties. Here, we propose a data-driven approach for the analysis and prediction of the HIV-1 interacting proteins (V

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29

Samia, Tariq. "Choice of Market Entry Mode is Contingent on Environment: Integrating the Resource Dependence and Contingency Theory Perspectives." International Journal of Science and Business 3, no. 5 (2019): 173–82. https://doi.org/10.5281/zenodo.3415347.

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Selection of the appropriate entry mode for internationalization is a crucial decision. Global firms contemplating foreign direct investment may incur huge costs due to wrong selection of entry mode. Environment, as a non-controllable factor, should guide these firms to choose a pertinent entry mode. This conceptual paper provides key propositions of the potential impact of entry mode selection on the success of the firm, building on resource dependency theory and contingency theory. The study proposes that the choice of entry mode selection by internationalizing Chinese firms, targeting devel

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Ligat, Gaëtan, Kaku Goto, Eloi Verrier, and Thomas F. Baumert. "Targeting Viral cccDNA for Cure of Chronic Hepatitis B." Current Hepatology Reports 19, no. 3 (2020): 235–44. http://dx.doi.org/10.1007/s11901-020-00534-w.

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Abstract Purpose of Review Chronic hepatitis B (CHB), caused by hepatitis B virus (HBV), is a major cause of advanced liver disease and hepatocellular carcinoma (HCC) worldwide. HBV replication is characterized by the synthesis of covalently closed circular (ccc) DNA which is not targeted by antiviral nucleos(t)ide analogues (NUCs) the key modality of standard of care. While HBV replication is successfully suppressed in treated patients, they remain at risk for developing HCC. While functional cure, characterized by loss of HBsAg, is the first goal of novel antiviral therapies, curative treatm

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Jühling, Frank, Antonio Saviano, Clara Ponsolles, et al. "Hepatitis B virus compartmentalization and single-cell differentiation in hepatocellular carcinoma." Life Science Alliance 4, no. 9 (2021): e202101036. http://dx.doi.org/10.26508/lsa.202101036.

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Chronic hepatitis B virus (HBV) infection is a major cause of hepatocellular carcinoma (HCC) world-wide. The molecular mechanisms of viral hepatocarcinogenesis are still partially understood. Here, we applied two complementary single-cell RNA-sequencing protocols to investigate HBV–HCC host cell interactions at the single cell level of patient-derived HCC. Computational analyses revealed a marked HCC heterogeneity with a robust and significant correlation between HBV reads and cancer cell differentiation. Viral reads significantly correlated with the expression of HBV-dependency factors such a

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Pitoyo, Agus Joko. "COMBATTING SEXUAL HARASSMENT AGAINST WOMEN MIGRANT WORKERS OVERSEAS: LOOKING AT THE CONTEXTUAL FACTORS." Populasi 24, no. 1 (2016): 36–56. http://dx.doi.org/10.22146/jp.23694.

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Violence against women is a criminal act. It involves not only in personal domain, but also within social arenas. It could be happened in social life, such as the fact of sexual harassment at work. Through qualitative retrospective cross-sectional methods, the study aimed to explore the contextual factors of sexual harassment which have occurred overseas among women migrant workers from Ponorogo, East Java, Indonesia. Several factors altogether were identi ed as logical elements contributing to the existence of sexual harassment, composed of personal factors, relationship, working environment

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Gan, Chun-Mei, Ting Tang, Zi-Yu Zhang, et al. "Unraveling the Intricacies of Powdery Mildew: Insights into Colonization, Plant Defense Mechanisms, and Future Strategies." International Journal of Molecular Sciences 26, no. 8 (2025): 3513. https://doi.org/10.3390/ijms26083513.

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Powdery mildew, a debilitating phytopathogen caused by biotrophic fungi within the order Erysiphales, endangers crop yields and global food security. Although traditional approaches have largely emphasized resistant cultivar development and chemical control, novel strategies are necessary to counter the advent of challenges, such as pathogen adaptation and climate change. This review fully discusses three principal areas of pathogen effector functions, e.g., the reactive oxygen species (ROS)-suppressive activity of CSEP087, and host susceptibility factors, like vesicle trafficking regulated by

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Isenberg, H. D. "Pathogenicity and virulence: another view." Clinical Microbiology Reviews 1, no. 1 (1988): 40–53. http://dx.doi.org/10.1128/cmr.1.1.40.

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The concepts of pathogenicity and virulence have governed our perception of microbial harmfulness since the time of Pasteur and Koch. These concepts resulted in the recognition and identification of numerous etiological agents and provided natural and synthetic agents effective in therapy and prevention of diseases. However, Koch's postulates--the premier product of this view--place the onus of harmfulness solely on the microbial world. Our recent experiences with polymicrobic and nosocomial infections, legionellosis, and acquired immunodeficiency syndrome point to the host as the major determ

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Vitetta, Luis, Matthew Bambling, and Esben Strodl. "Probiotics and Commensal Bacteria Metabolites Trigger Epigenetic Changes in the Gut and Influence Beneficial Mood Dispositions." Microorganisms 11, no. 5 (2023): 1334. http://dx.doi.org/10.3390/microorganisms11051334.

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The effect of the intestinal microbiome on the gut–brain axis has received considerable attention, strengthening the evidence that intestinal bacteria influence emotions and behavior. The colonic microbiome is important to health and the pattern of composition and concentration varies extensively in complexity from birth to adulthood. That is, host genetics and environmental factors are complicit in shaping the development of the intestinal microbiome to achieve immunological tolerance and metabolic homeostasis from birth. Given that the intestinal microbiome perseveres to maintain gut homeost

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LAM, RUO YI, MING SHE SEE, FAIZAH SHAROM-HARRISON, HAZLINA AHAMAD ZAKERI, and NOR OMAIMA HARUN. "HOST SPECIFICITY, INFECTION DYNAMICS, AND ALLERGENICITY IN Anisakis SPP. INFESTATION: A REVIEW." Universiti Malaysia Terengganu Journal of Undergraduate Research 6, no. 2 (2024): 62–75. http://dx.doi.org/10.46754/umtjur.v6i2.459.

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Fish and seafood are important in providing protein to human diets. However, they are susceptible to contamination by various parasites, such as nematodes, cestodes, and trematodes. Among these, Anisakis spp. and other species of trematodes belonging to the Anisakidae family are commonly identified in fish and shellfish, posing a significant health risk. This contamination poses a substantial risk to public health, particularly with the increasing prevalence of these parasites in marine fish. The globalisation of cuisines, including sushi, is one of the factors causing this development. The ri

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Miljan, Merilin, and Ronnie Cann. "Rethinking case marking and case alternation in Estonian." Nordic Journal of Linguistics 36, no. 3 (2013): 333–79. http://dx.doi.org/10.1017/s0332586513000309.

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In this paper, we argue for a view of case marking that does not treat case as the passive realisation of other morpho-syntactic properties of a construction but as independently bringing information to a clause. This different view of case entails that precise functions of case-marked expressions may be determined by the interaction of the case marking, the meaning of the host noun, the semantics of any predicate of which it is an argument and other contextually given factors. With respect to Estonian, it is argued that there is only one ‘structural’ case, the genitive, and this case marks no

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Lee, Jiae, Katelyn G. L. Ng, Kenneth M. Dombek, Dae Seok Eom, and Young V. Kwon. "Tumors overcome the action of the wasting factor ImpL2 by locally elevating Wnt/Wingless." Proceedings of the National Academy of Sciences 118, no. 23 (2021): e2020120118. http://dx.doi.org/10.1073/pnas.2020120118.

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Tumors often secrete wasting factors associated with atrophy and the degeneration of host tissues. If tumors were to be affected by the wasting factors, mechanisms allowing tumors to evade the adverse effects of the wasting factors must exist, and impairing such mechanisms may attenuate tumors. We use Drosophila midgut tumor models to show that tumors up-regulate Wingless (Wg) to oppose the growth-impeding effects caused by the wasting factor, ImpL2 (insulin-like growth factor binding protein [IGFBP]-related protein). Growth of Yorkie (Yki)-induced tumors is dependent on Wg while either elimin

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Kok, Laurence M. C., Laura Bungener, Geertruida H. de Bock, et al. "Risk factors associated with the development of moderate to severe chronic graft-versus-host disease after non-myeloablative conditioning allogeneic stem cell transplantation in patients with AML or MDS." Human Cell 33, no. 1 (2019): 243–51. http://dx.doi.org/10.1007/s13577-019-00297-7.

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AbstractModerate to severe chronic graft-versus-host disease (cGVHD) is associated with high morbidity, hospital dependency and poor quality of life. In this study, we analyzed a well-defined consecutive series of 98 patients with acute myelogenous leukemia/myelodysplastic syndrome (AML/MDS) who received allogeneic stem cell transplantation with non-myeloablative (NMA) conditioning to determine risk factors associated with the severity of cGVHD. cGVHD was defined according to the 2005 National Institute of Health consensus criteria. Transfusions before transplantation, presence of HLA antibodi

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Sultana, Rafia, Ateeb Ahmad Parray, Muhammad Riaz Hossain, Bachera Aktar, and Sabina Faiz Rashid. "“We are invisible to them”—Identifying the most vulnerable groups in humanitarian crises during the COVID-19 pandemic: The case of Rohingyas and the Host communities of Cox’s Bazar." PLOS Global Public Health 3, no. 6 (2023): e0000451. http://dx.doi.org/10.1371/journal.pgph.0000451.

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The COVID-19 pandemic has had an adverse impact on the Rohingya and the Bangladeshi host communities, which have been well documented in the literature. However, the specific groups of people rendered most vulnerable and marginalized during the pandemic have not been studied comprehensively. This paper draws on data to identify the most vulnerable groups of people within the Rohingya and the host communities of Cox’s Bazar, Bangladesh, during the COVID-19 pandemic. This study employed a systematic sequential method to identify the most vulnerable groups in the context of Rohingya and Host comm

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Walsh, Michael G., Anke Wiethoelter, and M. A. Haseeb. "The impact of human population pressure on flying fox niches and the potential consequences for Hendra virus spillover." Scientific Reports 7, no. 1 (2017): 8226. https://doi.org/10.5281/zenodo.13424953.

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(Uploaded by Plazi for the Bat Literature Project) Abstract Hendra virus (HeV) is an emerging pathogen of concern in Australia given its ability to spillover from its reservoir host, pteropid bats, to horses and further on to humans, and the severe clinical presentation typical in these latter incidental hosts. Specific human pressures over recent decades, such as expanding human populations, urbanization, and forest fragmentation, may have altered the ecological niche of Pteropus species acting as natural HeV reservoirs and may modulate spillover risk. This study explored the influence of int

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42

Walsh, Michael G., Anke Wiethoelter, and M. A. Haseeb. "The impact of human population pressure on flying fox niches and the potential consequences for Hendra virus spillover." Scientific Reports 7, no. 1 (2017): 8226. https://doi.org/10.5281/zenodo.13424953.

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Abstract:

(Uploaded by Plazi for the Bat Literature Project) Abstract Hendra virus (HeV) is an emerging pathogen of concern in Australia given its ability to spillover from its reservoir host, pteropid bats, to horses and further on to humans, and the severe clinical presentation typical in these latter incidental hosts. Specific human pressures over recent decades, such as expanding human populations, urbanization, and forest fragmentation, may have altered the ecological niche of Pteropus species acting as natural HeV reservoirs and may modulate spillover risk. This study explored the influence of int

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43

Walsh, Michael G., Anke Wiethoelter, and M. A. Haseeb. "The impact of human population pressure on flying fox niches and the potential consequences for Hendra virus spillover." Scientific Reports 7, no. 1 (2017): 8226. https://doi.org/10.5281/zenodo.13424953.

Full text

Abstract:

(Uploaded by Plazi for the Bat Literature Project) Abstract Hendra virus (HeV) is an emerging pathogen of concern in Australia given its ability to spillover from its reservoir host, pteropid bats, to horses and further on to humans, and the severe clinical presentation typical in these latter incidental hosts. Specific human pressures over recent decades, such as expanding human populations, urbanization, and forest fragmentation, may have altered the ecological niche of Pteropus species acting as natural HeV reservoirs and may modulate spillover risk. This study explored the influence of int

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44

Walsh, Michael G., Anke Wiethoelter, and M. A. Haseeb. "The impact of human population pressure on flying fox niches and the potential consequences for Hendra virus spillover." Scientific Reports 7, no. 1 (2017): 8226. https://doi.org/10.5281/zenodo.13424953.

Full text

Abstract:

(Uploaded by Plazi for the Bat Literature Project) Abstract Hendra virus (HeV) is an emerging pathogen of concern in Australia given its ability to spillover from its reservoir host, pteropid bats, to horses and further on to humans, and the severe clinical presentation typical in these latter incidental hosts. Specific human pressures over recent decades, such as expanding human populations, urbanization, and forest fragmentation, may have altered the ecological niche of Pteropus species acting as natural HeV reservoirs and may modulate spillover risk. This study explored the influence of int

APA, Harvard, Vancouver, ISO, and other styles

45

Walsh, Michael G., Anke Wiethoelter, and M. A. Haseeb. "The impact of human population pressure on flying fox niches and the potential consequences for Hendra virus spillover." Scientific Reports 7, no. 1 (2017): 8226. https://doi.org/10.5281/zenodo.13424953.

Full text

Abstract:

(Uploaded by Plazi for the Bat Literature Project) Abstract Hendra virus (HeV) is an emerging pathogen of concern in Australia given its ability to spillover from its reservoir host, pteropid bats, to horses and further on to humans, and the severe clinical presentation typical in these latter incidental hosts. Specific human pressures over recent decades, such as expanding human populations, urbanization, and forest fragmentation, may have altered the ecological niche of Pteropus species acting as natural HeV reservoirs and may modulate spillover risk. This study explored the influence of int

APA, Harvard, Vancouver, ISO, and other styles

46

Walsh, Michael G., Anke Wiethoelter, and M. A. Haseeb. "The impact of human population pressure on flying fox niches and the potential consequences for Hendra virus spillover." Scientific Reports 7, no. 1 (2017): 8226. https://doi.org/10.5281/zenodo.13424953.

Full text

Abstract:

(Uploaded by Plazi for the Bat Literature Project) Abstract Hendra virus (HeV) is an emerging pathogen of concern in Australia given its ability to spillover from its reservoir host, pteropid bats, to horses and further on to humans, and the severe clinical presentation typical in these latter incidental hosts. Specific human pressures over recent decades, such as expanding human populations, urbanization, and forest fragmentation, may have altered the ecological niche of Pteropus species acting as natural HeV reservoirs and may modulate spillover risk. This study explored the influence of int

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47

Surahio, Muhammad Kashan, Shengyu Gu, Hakim Ali Mahesar, and Mansoor Mumtaz Soomro. "China–Pakistan Economic Corridor: Macro Environmental Factors and Security Challenges." SAGE Open 12, no. 1 (2022): 215824402210798. http://dx.doi.org/10.1177/21582440221079821.

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Pakistan, excepting external issues, has been enduring from chronic problems, that is, political-military anarchy, bad-governance, interprovincial conflicts, social divisions, sectarian influence, and terrorism resulting negatively on inland politics, economics, socioculture, and techno-industry (PEST). This amplified domestic instability and governmental dependency toward external support. Appropriately, China’s recent FDI for CPEC is aimed to revive Pakistan’s energy, transport, infrastructure, industries and also procure China’s energy and trade transmission, and opportunities. So far, some

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Bates, C. J., D. M. O'Doherty, and D. Williams. "Flow instabilities in a graft anastomosis: A study of the instantaneous velocity fields." Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine 215, no. 6 (2001): 579–87. http://dx.doi.org/10.1243/0954411011536181.

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The major cause of arterial bypass graft failure is intimal hyperplasia. Fluctuating wall shear stresses in the graft, which are associated with disturbed flow, are believed to be important factors in the development and localization of intimal hyperplasia. This study, based upon water as the working fluid, has investigated the flow structure inside a 30° Y-junction with different fillet radii at the intersection between the graft and the host artery at various Reynolds numbers and distal outlet segment (DOS) to proximal outlet segment (POS) flow ratios. The structure of the flow has been inve

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Ortiz-Cobo, Monica, Jose Garcia-Martin, and Rosella Bianco. "Will the “normality” times come back? L2 learning motivation between immigrants and refugees before Covid-19." XLinguae 14, no. 1 (2021): 182–96. http://dx.doi.org/10.18355/xl.2021.14.01.15.

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In these turbulent times of changes and transformations where educational processes are being virtualized due to the pandemic, we must not forget the difficulties that this implies for certain vulnerable learners and some learning contexts. That is the case of the L2 learning by immigrants and refugees. Such learners already have a starting difficulty, both for not mastering the language of learning and for the digital divide, which is increased by the migration variable. This work analyses, within a context of “normality”, the motivation of immigrants and refugees, in the light of their links

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Hao, Zhipeng, Wei Xie, Xuelian Jiang, Zhaoxiang Wu, Xin Zhang, and Baodong Chen. "Arbuscular Mycorrhizal Fungus Improves Rhizobium–Glycyrrhiza Seedling Symbiosis under Drought Stress." Agronomy 9, no. 10 (2019): 572. http://dx.doi.org/10.3390/agronomy9100572.

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Rhizobia and arbuscular mycorrhizal (AM) fungi can potentially alleviate the abiotic stress on the legume Glycyrrhiza (licorice), while the potential benefits these symbiotic microbes offer to their host plant are strongly influenced by environmental factors. A greenhouse pot experiment was conducted to investigate the effects of single and combined inoculation with a rhizobium Mesorhizobium tianshanense Chen and an AM fungus Rhizophagus irregularis Walker & Schuessler on Glycyrrhiza uralensis Fisch. seedling performance under different water regimes. Drought stress inhibited rhizobium nod

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