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Dissertations / Theses on the topic 'Host target'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Runåker, Björn. "Distributed system simulation with host-based target offloading." Thesis, KTH, Skolan för datavetenskap och kommunikation (CSC), 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-165177.

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Scaling of TLM (Transaction Level Modeling) simulations for performance is difficult. In this project I will go through several causes of poor performance. This paper describes several simulation engines that use SystemC that are connected so they together simulate next generation radio base station. It also describes how to build a virtual network in, for security reasons, constrained environment where both virtual and physical equipment can connect the simulated target. Furthermore, it describes how to use the virtual network to improve the overall performance of the simulation. It is shown

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2

Abimbola, Abiola. "NetHostSensor Enhancing intrusion detection via an active target host." Thesis, Edinburgh Napier University, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.506365.

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3

Truchan, Hilary Kay. "Anaplasma phagocytophilum nutritional virulence mechanisms target the host cell secretory pathway." VCU Scholars Compass, 2014. http://scholarscompass.vcu.edu/etd/3620.

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Obligate intracellular pathogens must acquire host cell-derived nutrients to facilitate their survival. One such bacterial pathogen, Anaplasma phagocytophilum, replicates within neutrophils and non-phagocytic cells in a bacterial-modified, host cell-derived vacuole. The bacterium exploits host cell vesicular trafficking pathways to route nutrients to its vacuole and utilizes Rab GTPases, guanine nucleotide-dependent, vesicular trafficking regulators, to do so. We previously discovered that the A. phagocytophilum vacuolar membrane is decorated with a specific subset of Rab GTPases - Rab1, Rab4A

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VAEZI, ANZEHA ZAHRA. "Host defence peptides: mechanisms of membrane perturbation and target cell selectivity." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2015. http://hdl.handle.net/2108/201991.

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Host defence peptides (HDPs) are effector molecules of the innate immune system. They show broad activity against bacteria and cancer cells, usually by perturbing the permeability of cell membranes, leading to the death of pathogens by collapse of transmembrane electrochemical gradients and loss of important metabolites and cellular components. Due to this mechanism of action, development of resistance is unlikely. For this reason, HDPs are excellent candidates as a new class of therapeutics to address the problem of drugresistance pathogens. Pore formation in the pathogen membranes requires a

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5

Gao, Jiquan. "Interactions between a yeast retrotransposon and its host that influence target specificity." [Ames, Iowa : Iowa State University], 2009. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3369930.

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6

Breen, Susan Anne. "Investigation of the recognition and host target of the Phytophthora infestans effector PiAVR2." Thesis, University of Dundee, 2012. https://discovery.dundee.ac.uk/en/studentTheses/05c782d2-ddfa-4cd5-b4ab-5426f5fb8b32.

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This was a project joint between the University of Dundee and The James Hutton Institute where both parties were interested in further understanding the interactions between plant host proteins and pathogen effector proteins. An objective of this thesis was to determine the host target of the Phytophthora infestans effector PiAVR2 and the means by which this avirulence protein is recognised by the potato resistance protein, R2. Prior to this PhD, forward genetic studies identified three RXLR effector encoding genes within the AVR2 locus. By use of transient co-expression with the resistance ge

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7

Abomughaid, Mosleh. "Hepatitis C virus induced changes in cellular lipids - identifying novel host antiviral drug target." Thesis, The University of Sydney, 2014. http://hdl.handle.net/2123/12929.

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Nearly 300,000 Australians and 200 million people throughout the world have been exposed to the hepatitis C virus (HCV). Furthermore, over 10,000 new infections are reported on an annual basis. HCV is associated with chronic disease leading to hepatic fibrosis that may progress to liver failure and cancer, and is a leading cause of chronic hepatitis, cirrhosis and hepatocellular carcinoma. Hepatitis C virus (HCV) replication is closely linked to lipid metabolism. Therefore, lipidomic analysis of HCV infected hepatic cells can offer insights into the pathogenesis of HCV infection and identify

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8

Paudyal, Bhesh Raj [Verfasser]. "Small lipid mediators in experimental tuberculosis as target for host-directed therapy / Bhesh Raj Paudyal." Lübeck : Zentrale Hochschulbibliothek Lübeck, 2017. http://d-nb.info/1147619638/34.

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9

Böhm, Manja [Verfasser]. "Molecular mechanisms of Campylobacter jejuni induced transmigration and invasion of host target cells / Manja Böhm." Magdeburg : Universitätsbibliothek, 2012. http://d-nb.info/1053913990/34.

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10

Carney, Vanessa A., and University of Lethbridge Faculty of Arts and Science. "Ecological interactions of biological control agent, Mecinus Janthinus Germar, and its target host, Linaria Dalmatica (L.) Mill." Thesis, Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2003, 2003. http://hdl.handle.net/10133/214.

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There has been little documentation of the success of introduced agents for classical weed biological control. Field evaluation of an insect's establishment, spread and early host impact within its new environment must be performed before agent success can either be doucmented or predicted. Population attributes of the ednophagous biological control agent, Mecinus janthinus Germar (Coleoptera: Curculionidae), and interactions with its target weed, Dalmation toadflax, (Linaria dalmatica (L.) Mill.) (Scrophulariaceae), were explored across variable levels of resource availability and insect abun

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11

Kleine-Weber, Hannah [Verfasser]. "Characterization of host cell factors used by emerging coronaviruses for entry into target cells / Hannah Kleine-Weber." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2020. http://d-nb.info/1214887074/34.

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12

Law, Robyn Jamie. "Host target and function of the type III secreted effectors NleB and EspL of attaching and effacing bacterial pathogens." Thesis, University of British Columbia, 2015. http://hdl.handle.net/2429/53341.

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Enteropathogenic Escherichia coli (EPEC) and enterohemorrhagic E. coli (EHEC) cause enteric diseases resulting in significant morbidity and mortality worldwide. EPEC is a leading cause of potentially fatal watery diarrhea associated with vomiting, fever and dehydration in young children in developing countries, while EHEC causes severe gastroenteritis in both developing and industrialized nations. The success of these pathogens relies on their ability to inject secreted effectors directly into host cells that manipulate a variety of host cell signaling pathways while the pathogen remains ext

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13

Lagadinos, Alexander N. "Human Cytomegalovirus Reprograms the Expression of Host Micro-RNAs whose Target Networks are Required for Viral Replication: A Dissertation." eScholarship@UMMS, 2013. https://escholarship.umassmed.edu/gsbs_diss/683.

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The parasitic nature of viruses requires that they adapt to their host environment in order to persist. Herpesviruses are among the largest and most genetically complex human viruses and they have evolved mechanisms that manipulate a variety of cellular pathways and processes required to replicate and persist within their hosts. Human cytomegalovirus (HCMV), a member of the β- herpesvirus sub-family, has the capacity to influence the expression of many host genes in an effort to create an optimal environment for infection. One mechanism utilized by HCMV to alter gene expression is the host RNA

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14

Samassa, Fatoumata. "New insights into the manipulation of the host adaptive immune response by Shigella : the immunological synapse as a target." Thesis, Sorbonne Paris Cité, 2018. http://www.theses.fr/2018USPCC293.

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La manipulation de la réponse immunitaire innée au cours des infections bactériennes a été largement documentée contrairement à celle de la réponse adaptative. C’est le cas de l’entérobactérie à Gram-négatif Shigella qui est l’agent causal de la dysenterie bacillaire, une rectocolite aiguë. L’inflammation due à l’invasion de la muqueuse colique et la destruction qui en résulte reposent sur l’expression d’un Système de Sécrétion de Type Trois (SST3) par Shigella. Ce système assure l’injection d’effecteurs de virulence bactériens dans le cytoplasme de la cellule hôte afin de détourner les foncti

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Lagadinos, Alexander N. "Human Cytomegalovirus Reprograms the Expression of Host Micro-RNAs whose Target Networks are Required for Viral Replication: A Dissertation." eScholarship@UMMS, 2008. http://escholarship.umassmed.edu/gsbs_diss/683.

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The parasitic nature of viruses requires that they adapt to their host environment in order to persist. Herpesviruses are among the largest and most genetically complex human viruses and they have evolved mechanisms that manipulate a variety of cellular pathways and processes required to replicate and persist within their hosts. Human cytomegalovirus (HCMV), a member of the β- herpesvirus sub-family, has the capacity to influence the expression of many host genes in an effort to create an optimal environment for infection. One mechanism utilized by HCMV to alter gene expression is the host RNA

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16

Ibba, Roberta. "Antiviral drug discovery: from synthesis of virus-targeting molecules to fragment-based lead discovery for a novel host target." Doctoral thesis, Università degli Studi di Cagliari, 2020. http://hdl.handle.net/11584/284395.

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Antiviral Drug Discovery is still a great challenge due to the virus's ability to mutate in order to survive and the continuous discovery of new pathogen viruses. Viral infection is caused by the presence of a virus in the body. Antivirals are compounds, either chemically synthesised or produced by a living organism, that inhibit viral infection and replication. Antivirals interfere with one or more of the virus replication cycle stage. Based on their inhibitory mechanism, antivirals can be divided into two groups: inhibitors that target the viruses (VTAs) or inhibitors that target host cell f

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17

Oliveira, Wilson Prates de. "Arquitetura de software para sistemas de tempo real." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/3/3152/tde-13012012-103355/.

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O desenvolvimento de sistemas de controle em plataformas de tempo real é uma tarefa que envolve Engenharia de Controle e Ciência da Computação. Nas últimas décadas, estas áreas se desenvolveram como áreas independentes. Este trabalho busca diminuir distância entre as áreas propondo a utilização de métodos de Engenharia de Software em uma fase de modelagem do software de controle. Uma das propostas apresentadas no trabalho é a utilização de frameworks orientados a objetos no processo de Rapid Control Prototyping (RCP) para substituir a geração automática de código, eliminar os problemas de inte

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18

Huber, Annette [Verfasser], and Thomas [Gutachter] Rudel. "Chlamydial deubiquitinase ChlaDUB1 as regulator of host cell apoptosis and new target for anti-chlamydial therapy / Annette Huber. Gutachter: Thomas Rudel." Würzburg : Universität Würzburg, 2015. http://d-nb.info/1102829544/34.

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19

Marcelino, Eduardo Miguel Baptista Ferreira. "Protein disulfide isomerase as a target for besnoitiosis therapy : molecular characterization and studies of its role in infection and host immune response." Doctoral thesis, Universidade de Lisboa. Faculdade de Medicina Veterinária, 2016. http://hdl.handle.net/10400.5/11693.

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Tese de Doutoramento em Ciências Veterinárias na especialidade de Sanidade Animal<br>amedmarcelino@fmv.ulisboa.pt<br>Besnoitia besnoiti is an apicomplexan parasite responsible for bovine besnoitiosis, a disease with a high prevalence in tropical and subtropical regions and re-emerging in Europe. Despite the great economical losses associated with besnoitiosis, this disease has been underestimated and poorly studied, and neither an effective therapy nor a vaccine to be used in Europe is available. Protein disulfide isomerase (PDI) is an essential enzyme for the acquisition of the correct three-

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20

Shah, Pranali Nitin [Verfasser], Ralf [Akademischer Betreuer] Dressel, Lutz [Gutachter] Walter, and Holger [Gutachter] Reichardt. "Identification of genes regulated in target organs of acute graft versus host disease in different organs in different species / Pranali Nitin Shah ; Gutachter: Lutz Walter, Holger Reichardt ; Betreuer: Ralf Dressel." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2016. http://d-nb.info/1138835595/34.

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21

Barron, M. C. "Population ecology of the red admiral butterfly (Bassaris gonerilla) and the effects of non-target parasitism by Pteromalus puparum." Lincoln University, 2004. http://hdl.handle.net/10182/1763.

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There is anecdotal evidence that populations of the New Zealand endemic red admiral butterfly Bassaris gonerilla (F.) have declined since the early 1900s. This decline has been associated with the introduction of the generalist pupal parasitoids Pteromalus puparum (L.) and Echthromorpha intricatoria (F.). The former was deliberately introduced for the biological control of the cabbage white butterfly (Pieris rapae (L.)); the latter is an adventitious arrival from Australia. The objective of this thesis was to quantify, using population models, the effect that P. puparum is having on B. goneril

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22

Rogers, Lindsay Deborah. "Proteomic analysis of Salmonella-host interactions reveals novel host targets of SopB." Thesis, University of British Columbia, 2011. http://hdl.handle.net/2429/33597.

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Salmonella enterica is an intracellular bacterium causing gastroenteritis and typhoid fever. Virulence is achieved by two type III secretion systems (T3SS) encoded on Salmonella pathogenicity islands 1 and 2 (SPI-1 and SPI-2) that translocate effector proteins into host cells where they mimic or block host protein function. Effectors translocated by T3SS-1 facilitate internalization of the bacteria into the Salmonella-containing vacuole (SCV), actively stimulate intracellular signaling cascades, and regulate trafficking of the SCV to avoid degradation. A T3SS-1 effector, SopB has been shown to

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23

Aristizabal, Claudia. "Intégration des effets de site dans les méthodes d'estimation probabiliste de l'aléa sismique." Thesis, Université Grenoble Alpes (ComUE), 2018. http://www.theses.fr/2018GREAU011/document.

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Les travaux de cette thèse s'inscrivent dans l'objectif général de fournir des recommandations sur la façon d'intégrer les effets du site dans l'évaluation probabiliste des risques sismiques, mieux connue sous le nom de PSHA, une méthodologie connue et utilisée à l'échelle mondiale pour estimer l'aléa et le risque sismiques à l'échelle régionale et locale. Nous passons donc en revue les méthodes disponibles dans la littérature pour obtenir la courbe d'aléa sismique en surface d'un site non-rocheux, en commençant par les méthodes les plus simples et plus génériques (partiellement probabiliste),

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24

Kidane, Yared H. "The Landscape of Host Transcriptional Response Programs Commonly Perturbed by Infectious Pathogens: Towards Host-Oriented Broad-Spectrum Drug." Diss., Virginia Tech, 2012. http://hdl.handle.net/10919/77368.

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The threat from infectious diseases dates as far back as prehistoric times. Pathogens continue to pose serious challenges to human health. The emergence and spread of diseases such as HIV/AIDS, Severe Acute Respiratory Syndrome (SARS), avian influenza, and the threats of bioterrorism have made infectious diseases major public health concerns. Despite many successes in the discovery of anti-infective medications, the treatment of infectious diseases faces serious challenges, which include (i) the emergence and reemergence of infectious pathogens, (ii) the ability of pathogens to adapt and devel

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Kidane, Yared Habteselassie. "The Landscape of Host Transcriptional Response Programs Commonly Perturbed by Infectious Pathogens: Towards Host-Oriented Broad-Spectrum Drug." Diss., Virginia Tech, 2012. http://hdl.handle.net/10919/77368.

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The threat from infectious diseases dates as far back as prehistoric times. Pathogens continue to pose serious challenges to human health. The emergence and spread of diseases such as HIV/AIDS, Severe Acute Respiratory Syndrome (SARS), avian influenza, and the threats of bioterrorism have made infectious diseases major public health concerns. Despite many successes in the discovery of anti-infective medications, the treatment of infectious diseases faces serious challenges, which include (i) the emergence and reemergence of infectious pathogens, (ii) the ability of pathogens to adapt and devel

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Capewell, Samantha Jessica. "Structural and functional studies of protein targets at the host-pathogen interface." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/9636.

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Ferric ABC Transporters. Pathogenic bacteria have evolved specialised iron acquisition systems that allow them to effectively colonise a host. One of these systems is the ferric binding protein (Fbp) complex that is a member of the ATP-Binding Cassette (ABC) superfamily of small molecule transporters. The Fbp complex is made up of three-components (FbpABC) that transports ferric iron from the periplasm to the cytoplasm of many Gram negative bacteria. FbpA binds iron in the periplasm and transports it to the FbpB transporter complex that permeates the cytoplasmic membrane. Here the iron is acti

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Lassalle, Damien. "Les pore forming toxin chez les Lophotrochozoaires : exemple des organismes Biomphalaria glabrata/ Schistosoma mansoni A New Assessment of Thioester-Containing Proteins Diversity of the Freshwater Snail Biomphalaria glabrata Cholesterol-TEG addition at the 5’end of siRNA allows significant increase of its uptake by hemocytes from Biomphalaria glabrata, the schistosomiasis vector snail. Under review in PeeJ. Schistosoma mansoni lysine specific demethylase (SmLSD1) is a druggable target involved in parasite survival, oviposition and stem cell proliferation." Thesis, Perpignan, 2020. https://theses-public.univ-perp.fr/2020PERP0036.pdf.

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La bilharziose est une maladie touchant 230 millions de personnes dans le monde (source OMS). Cette parasitose est provoquée par le schistosome, un vers plat parasite nommé Schistosoma mansoni. Avant de pénétrer dans l’organisme humain par la peau, ce parasite se développe chez un escargot d’eau douce, Biomphalaria glabrata, qui lui sert d’hôte intermédiaire. Nous avons dans ce contexte identifié et étudié deux protéines appartenant à la famille des pore formingtoxins (PFTs), que nous avons appelé Biomphalysine et Glabralysine. Les PFTs sont des effecteurs très connus dans le monde procaryote

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28

Alouffi, Abdulaziz. "Infiltrins as a novel regulatory principle of host-parasite interactions : new targets for vaccination?" Thesis, University of Nottingham, 2017. http://eprints.nottingham.ac.uk/43501/.

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Infiltrins, or pathogen-secreted host nucleus infiltrating proteins, are potential new targets for the development of more efficient vaccines against helminthic parasites. The archetypal infiltrin is IL-4 inducing principle from S. mansoni eggs (IPSE/alpha-1, also known as SmIPSE), a glycoprotein secreted by Schistosoma mansoni eggs, and characterised by the simultaneous presence of a classical secretory signal and a nuclear localisation signal. Within minutes following uptake by mammalian host cells, IP SE/alpha-1 translocates to their nucleus and binds to Deoxyribonucleic acid. This suggests

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Thompson, Michael Ryan Haden. "An Evaluation of Host Factors as Novel Therapeutic Targets During Influenza Infection Using RNA Technologies." CSUSB ScholarWorks, 2018. https://scholarworks.lib.csusb.edu/etd/721.

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Influenza A is a single-stranded, multi-segmented, negative sense RNA virus of the family Orthomyxoviridae and is the causative agent of seasonal Influenza. Influenza viruses cause significant impacts on a global scale regarding public health and economics. Annual influenza virus infections in the United States account for over 200,000 hospitalizations, up to 49,000 deaths, and an $87.1 billion economic burden. Influenza A virus has caused several pandemics since the turn of the 20th century. The effects of Influenza on public health and economics, compounded with low efficacy of the annual va

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30

Gunnarsson, Erik. "Egenskaper hos fyllnadsmassor : En studie av fyllnadsmassors påverkan på spridning av restföroreningar från mark." Thesis, Umeå universitet, Institutionen för ekologi, miljö och geovetenskap, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-93559.

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The aim of this study was to estimate how different filling materials affect the mobilization of pollution residue in remediated soil. The aim was also to assess criteria that should be fulfilled for the soil properties of these filling materials. The study was partly based on target value calculations where the impact of varied TOC, hydraulic conductivity and porosity affected the mobility of toluene, trichloroethene, benso(a)pyrene and arsenic residue in the soil. An evaluation of the potential mobility of soil pollution residues where filling materials had been used was carried out for five

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Hall, Benjamin. "Plant pathogen effector proteins and their host targets : functional studies and manipulation to generate enhanced resistance." Thesis, University of East Anglia, 2016. https://ueaeprints.uea.ac.uk/62310/.

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As global population expands, so does its demand for food. This will require vast amounts of plant-derived calories. This increased pressure means it is vital that we do more with less; less land, less water, less chemical input and less labour. One major threat to crop production is posed by plant pests and pathogens. In particular, filamentous plant pathogens – oomycetes and fungi – are among the most devastating organisms known to agriculture. With their rapidly evolving genomes which specialise in breaking plant immune systems and chemical control methods, control of these pathogens is bec

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Wu, Dousheng [Verfasser], and Thomas [Akademischer Betreuer] Lahaye. "Identification and characterization of host targets of Ralstonia solanacearum TAL effector Brg11 / Dousheng Wu ; Betreuer: Thomas Lahaye." Tübingen : Universitätsbibliothek Tübingen, 2019. http://d-nb.info/1203070780/34.

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Marques, Monteiro Amaro Tiago Miguel. "Unveiling and exploiting Phytophthora capsici effectors and their host targets, with an emphasis on CRN effector proteins." Thesis, University of Dundee, 2017. https://discovery.dundee.ac.uk/en/studentTheses/2bd6e090-2904-4ed2-abcb-7b397684e430.

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Phytophthora capsici is a devastating plant pathogen for which virulence is aided by the secretion of effectors, including cytoplasmic effectors from the CRN (CRinkling and Necrosis) family. CRN effectors were first described in oomycetes by their capacity to induce host cell death. Nevertheless, despite recent efforts aiming to elucidate CRN virulence functions, the virulence relevance of CRN mediated cell death remains unknown. In this thesis, by performing a PCR based random mutagenesis screen on P. capsici CRN effector PcCRN83_152, we showed that PcCRN83_152 cell death is not required for

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Belkhadir, Youssef. "Genetic and biochemical characterization of host protein complexes containing the targets of AvrRpm1 and AvrB in Arabidopsis." Paris 11, 2005. http://www.theses.fr/2005PA112248.

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"Les plantes ont un système immunitaire inné pour combattre les pathogènes. Pour reconnaître les agents pathogènes les systèmes immunitaires des plantes dépendent de protéines dites de surveillance. Le concept de relation " géne-pour-géne " gouverne établi que a un géne de résistance (R) de l'hôte correspond un géne d'avirulence (avr) du pathogène. Quand les deux sont exprimes par le pathogène et son hôte une réaction dite de résistance, ou la plante limite l'infection, est mise en place. Si l'un ou/et l'autre sont inactifs ou manquants une réaction sensible, ou la plante se fait coloniser, se

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Klünemann, Martina [Verfasser], and Kiran R. [Akademischer Betreuer] Patil. "Human gut bacteria interactions with host-targeted drugs / Martina Klünemann ; Betreuer: Kiran R. Patil." Heidelberg : Universitätsbibliothek Heidelberg, 2018. http://d-nb.info/1177383772/34.

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Bruiners, Natalie. "Investigating the Human-M. tuberculosis interactome to identify the host targets of ESAT-6 and other mycobacterial antigens." Thesis, Stellenbosch : Stellenbosch University, 2012. http://hdl.handle.net/10019.1/71977.

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Thesis (PhD)--Stellenbosch University, 2012.<br>ENGLISH ABSTRACT: The causative agent of human tuberculosis, Mycobacterium tuberculosis, is an intracellular pathogen that secretes virulence factors, namely ESAT-6 and CFP-10, as substrates of the ESX-1 secretion system. It is hypothesised that these substrates interact with host proteins in a targeted manner in order to elicit a required immune response, and they have been shown to be involved in processes related to pro-inflammatory responses, necrosis, apoptosis, membrane lysis and cytolysis. However, the biological function of ESX-1 sub

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Beyene, Aster. "Studies of the hepatitis C virus envelope proteins : interaction with host cells and as targets for the humoral response /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-074-5/.

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Wongdontree, Paprapach. "Staphylococcus aureus Adaptation to FASII-Targeted Antibiotics in Host Environments and Strategies to Potentiate Antibiotic Activities." Electronic Thesis or Diss., université Paris-Saclay, 2023. http://www.theses.fr/2023UPASB088.

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Staphylococcus aureus est un pathogène opportuniste responsable d’infections difficiles à traiter dues à l’inefficacité des antibiotiques actuels. En 2019, cette bactérie a causé le taux de mortalité mondial le plus élevé. La nécessité de recherche de nouveaux antibiotiques a permis de développer de nouvelles molécules inhibant la synthèse des acides gras de type II (FASII). Cependant, ces molécules anti-FASII présentent une faiblesse : S. aureus et les pathogènes Firmicutes sont capables de contourner l’inhibition de FASII par incorporation d’acides gras environnementaux présents dans l’hôte

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Ieva, Christopher S. "The Holistic Targeting (HOT) methodology as the means to improve Information Operations (IO) target development and prioritization." Thesis, Monterey, Calif. : Naval Postgraduate School, 2008. http://edocs.nps.edu/npspubs/scholarly/theses/2008/Sept/08Sep%5FIeva.pdf.

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Thesis (M.S. in Information Warfare Systems Engineering)--Naval Postgraduate School, September 2008.<br>Thesis Advisor(s): Iatrou, Steven J. "September 2008." Description based on title screen as viewed on November 5, 2008. Includes bibliographical references (p. 85-89). Also available in print.

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Boqvist, Julia, Alice Nilsson, and Jennifer Saado. "Elevers våld mot lärare : Förekomst och sambandet till personliga attribut hos lärarna samt negativa emotionella konsekvenser." Thesis, Örebro universitet, Institutionen för juridik, psykologi och socialt arbete, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-74807.

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Syftet var att undersöka elevers fysiska och psykiska våld mot lärare utifrån personliga attribut hos lärarna samt om förekomst av våld kan förknippas med negativa emotionella konsekvenser. En enkät besvarades av 246 lärare (M = 46 år, SD = 10,50) och resultaten visade att lärarna upplevde att psykiskt våld förekom i högre utsträckning än fysiskt våld. Resultaten visade även att ju mer bristande auktoritet och klassrumshantering som lärarna uppvisade, desto mer frekvent upplevde de fysiskt och psykiskt våld. Vidare visade resultaten att ju mindre hjälpsam och uppskattad lärarna var av eleverna

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41

Meyer, Bjoern. "Molecular studies of the Tacaribe virus nucleoprotein (NP) : identification and characterisation of virus-host interactions as novel anti-arenavirus drug targets." Thesis, University of St Andrews, 2014. http://hdl.handle.net/10023/6319.

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Arenaviruses cause an estimated 300,000 – 500,000 infections annually. Currently there is no arenavirus-specific antiviral drug available to treat these infections. This study sought to use the non-pathogenic New World arenavirus Tacaribe virus (TCRV) as a model for the pathogenic Junin virus (JUNV) and Machupo virus (MACV) that cause haemorrhagic fevers in South America. TCRV was used to explore three different approaches in the search for an antiviral drug against arenavirus infection targeted specifically against the viral nucleoprotein (NP). Of the four expressed arenaviral proteins, NP is

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Laurenson, Yan Christian Stephen Mountfort. "Modelling nematode infections in sheep and parasite control strategies." Thesis, University of Edinburgh, 2012. http://hdl.handle.net/1842/8178.

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Gastrointestinal parasitism in grazing lambs adversely affects animal performance and welfare, causing significant production losses for the sheep industry. Control of gastrointestinal parasitism using chemotherapeutic treatment is under threat due to the emergence of anthelmintic resistance, thus stimulating research into alternative control strategies. Whilst investigating control strategies experimentally can be costly and time consuming, using a mathematical modelling approach can reduce such constraints. A previously developed model which describes the impact of host nutrition, genotype a

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Pospíšil, Petr. "Optimalizace predikce pozice v síti." Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2008. http://www.nusl.cz/ntk/nusl-217436.

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This work is about position prediction in network, it is focused to find Landmark closest to the Host in the network (with lowest distance vector). The algorithm is based on GNP system. In terms of GNP system simulation was selected method for mathematical part of position prediction. The method was Simplex Downhill. The designed algorithm was implemented in Java. In the first step chose Host continent by meassuring the distance vector. In next step is selected nearest part in the continent. In conclusion estimate Host its position and then closest Landmark. Results from this work is important

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Caliando, Brian James. "Targeted destruction of intracellular DNA using a CRISPR-based genetic device that can be carried indefinitely in the host genome." Thesis, Massachusetts Institute of Technology, 2015. http://hdl.handle.net/1721.1/99051.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biological Engineering, 2015.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (pages 101-104).<br>Environmental release of synthetic DNA resulting from the disposal of spent microbial biocatalyst potentially represents an ecological risk to the environment or a financial risk to biotechnology firms, who might have their intellectual property stolen as a consequence. Thus, a genetically-encoded device that is capable of degrading DNA in a controlled manner would be a valuable and enabling tool.

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Rassuchine, Jennifer Melissa. "Enhanced hot electron confinement and isochoric heating in high contrast ultra-intense laser produced plasmas via novel conical micro-target design." abstract and full text PDF (free order & download UNR users only), 2007. http://0-gateway.proquest.com.innopac.library.unr.edu/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3289454.

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Garcia, Sofia Matos Flores Évora. "Host-induced changes in the cell surface N-linked glycoproteins, from Aspergillus fumigatus. Search for specific targets with potential for clinical therapy and/or diagnosis." Master's thesis, Faculdade de Ciências e Tecnologia, 2012. http://hdl.handle.net/10362/8194.

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This dissertation is presented to obtain a Master degree in Structural and Functional Biochemistry<br>The fungus Aspergillus fumigatus is responsible for causing invasive aspergillosis in human lungs, a fatal disease in immunocompromised patients. The development of such diseases is typically associated with a deficient immune response in the host as well as with phenotypic changes at cellular level of the fungus itself. The sequencing of the fungal genome has allowed the study of the proteome and its constituents, making it possible to explain the reason to such changes. The collection of ca

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Gudial, Gurbir Kaur. "ISOLATING THE TARGETS OF SIX TRANSCRIPTION FACTOR IN EPHYDATIA MUELLERI AND IDENTIFYING THE ROLE OF THE SUPEROXIDE DISMUTASE 6 IN HOST IMMUNE RESPONSE TO TRICHOMONAS VAGINALIS." Scholarly Commons, 2017. https://scholarlycommons.pacific.edu/uop_etds/2972.

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Sponges are the descendants of the oldest members of the metazoan phylogenetic lineage and their genome contains animal specific genes but lack true tissues, organ systems, and neurons. Thus, the sponge model system can be used to elucidate origin of developmental processes. The PSED (RDGN) network (Pax/Six/Eya/Dac) is important in development of eyes, muscles, and other structures in Bilaterians. Similarly, sponges contain a precursor Pax-Six gene network. The Ephydatia muelleri (Em) PaxB protein binds to a Pax2/5/8 consensus sequence site and two cis-regulatory elements upstream and one intr

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Simon, Jason E. "Effects of Multimodal Police and Community Development Interventions on Violent Crime in a Target Area of Youngstown, Ohio." Youngstown State University / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ysu1577807036428137.

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Hård, af Segerstad Per. "Artificiella neurala nät för datorseende hos en luftmålsrobot." Thesis, Försvarshögskolan, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:fhs:diva-7530.

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Studiens syfte är att öka förståelsen för möjligheterna med modern artificiell intelligens (AI) vid militär användning genom att bidra med information om ny teknik. Moderna civila applikationer av datorseende som skapats genom användande av så kallade artificiella neurala nät visar resultat som närmar sig den mänskliga synens nivå när det gäller att känna igen olika saker i sin omgivning. Denna studie motiveras av dessa observationer inom området AI i förhållande till situationer i luftstrid då pilotens syn används för att känna igen flygplan innan det bekämpas. Exempelvis vid användande av hj

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Gaber, Moawad Hanaa Mohamed Verfasser], Ulrike [Akademischer Betreuer] [Protzer-Knolle, Andreas F. K. [Gutachter] Umgelter, and Fabian K. [Gutachter] Geisler. "Hepatitis C virus control: viral resistance, new therapeutic targets and host defense / Hanaa Mohamed Gaber Moawad ; Gutachter: Andreas F. K. Umgelter, Fabian K. Geisler ; Betreuer: Ulrike Protzer." München : Universitätsbibliothek der TU München, 2016. http://d-nb.info/1117135144/34.

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