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Misiuk, Andrzej, Jadwiga Bak-Misiuk, Barbara Surma, Wojciech Wierzchowski, Krzysztof Wieteska, Charalampos A. Londos, Nikolai V. Abrosimov, and Jacek Kucytowski. "Impact of Hydrostatic Pressure Applied at Annealing on Homogeneity of Si-Ge Single Crystals." Solid State Phenomena 178-179 (August 2011): 35–40. http://dx.doi.org/10.4028/www.scientific.net/ssp.178-179.35.
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Creation and transformation of defects in single crystalline (001) oriented Si-Ge with about 5.6 at. % Ge content, containing oxygen interstitials, Oi’s, at 9x1017cm-3 level, were investigated, after processing for 5 h at up to 1400 K (HT) under Ar pressure to 1.1 GPa (HP), by X-ray, synchrotron, infrared and photoluminescence methods. To create nucleation centres for Oi’s precipitation, some samples were pre-annealed for 10 h at 1000 K under 105 Pa. HT-HP treatment at 1230/1400 K results in improved sample homogeneity and crystallographic perfection. HT-HP induced changes in Si-Ge are related mainly to HP-stimulated diffusivity of Ge.
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Riecken, Jan F., Gunter Heymann, Wilfried Hermes, Ute Ch Rodewald, Rolf-Dieter Hoffmann, Hubert Huppertz, and Rainer Pöttgen. "High-pressure / High-temperature Studies on the Stannides RENiSn (RE = Ce, Pr, Nd, Sm) and REPdSn (RE = La, Pr, Nd)." Zeitschrift für Naturforschung B 63, no. 6 (June 1, 2008): 695–706. http://dx.doi.org/10.1515/znb-2008-0616.
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The normal-pressure (NP) orthorhombic TiNiSi-type (space group Pnma) stannides RENiSn (RE = Ce, Pr, Nd, Sm) and REPdSn (RE = La, Pr, Nd) were transformed into the corresponding hexagonal ZrNiAl-type (space group P6̄2m) high-pressure (HP) modifications under multianvil high-pressure (7.5 - 11.5 GPa) high-temperature (1100 - 1200 °C) conditions. The structures of NP-CeNiSn, HPPrNiSn, NP-NdNiSn, HP-LaPdSn, HP-PrPdSn, and HP-NdPdSn were refined from single crystal X-ray diffractometer data. Structural data for HP-SmNiSn were obtained from a Rietveld powder refinement. The high-pressure phase transition significantly changes the rare earth coordination, i. e. 4 RE + 6 Ni(Pd) + 6 Sn atoms for the NP-phases and 6 RE + 5 Ni(Pd) + 6 Sn atoms for the HPphases. Susceptibility measurements of HP-PrPdSn and HP-NdPdSn reveal paramagnetic behavior with experimental magnetic moments of 3.61(1) μB/Pr atom and 3.66(1) μB/Nd atom, respectively. Low-temperature susceptibility and specific heat data point to inhomogeneous magnetism and spinglass behavior, respectively.
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Varodi, Codruta, Florina Pogacean, Marin Gheorghe, Valentin Mirel, Maria Coros, Lucian Barbu-Tudoran, Raluca-Ioana Stefan-van Staden, and Stela Pruneanu. "Stone Paper as a New Substrate to Fabricate Flexible Screen-Printed Electrodes for the Electrochemical Detection of Dopamine." Sensors 20, no. 12 (June 26, 2020): 3609. http://dx.doi.org/10.3390/s20123609.
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Flexible screen-printed electrodes (HP) were fabricated on stone paper substrate and amperometrically modified with gold nanoparticles (HP-AuNPs). The modified electrode displayed improved electronic transport properties, reflected in a low charge-transfer resistance (1220 Ω) and high apparent heterogeneous electron transfer rate constant (1.94 × 10−3 cm/s). The voltammetric detection of dopamine (DA) was tested with HP and HP-AuNPs electrodes in standard laboratory solutions (pH 6 phosphate-buffered saline (PBS)) containing various concentrations of analyte (10−7–10−3 M). As expected, the modified electrode exhibits superior performances in terms of linear range (10−7–10−3 M) and limit of detection (3 × 10−8 M), in comparison with bare HP. The determination of DA was tested with HP-AuNPs in spiked artificial urine and in pharmaceutical drug solution (ZENTIVA) that contained dopamine hydrochloride (5 mg/mL). The results obtained indicated a very good DA determination in artificial urine without significant matrix effects. In the case of the pharmaceutical drug solution, the DA determination was affected by the interfering species present in the vial, such as sodium metabisulfite, maleic acid, sodium chloride, and propylene glycol.
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Vitzthum, Daniela, Ingo Widmann, Markus Plank, Bastian Joachim-Mrosko, and Hubert Huppertz. "High-pressure synthesis and crystal structure of HP-Al2B3O7(OH)." Zeitschrift für Naturforschung B 75, no. 11 (November 26, 2020): 975–81. http://dx.doi.org/10.1515/znb-2020-0151.
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AbstractOrthorhombic HP-Al2B3O7(OH) was synthesized in a Walker-type multianvil apparatus under high-pressure/high-temperature conditions of 12.4 GPa and 1200 °C, respectively. Its structure is isotypic to that of Ga2B3O7(OH) and has been determined via single-crystal X-ray diffraction at room temperature. HP-Al2B3O7(OH) crystallizes in the space group Cmce (Z = 8) with the lattice parameters a = 10.3124(4), b = 7.3313(3), c = 10.4801(5) Å, and V = 792.33(6) Å3. The compound has also been characterized by IR and Raman spectroscopy.
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Sumardiyanto, Didit, and Sri Endah Susilowati. "PENGARUH TEKANAN POMPA BAHAN BAKAR TEKANAN TINGGI TERHADAP KINERJA MESIN." JURNAL KAJIAN TEKNIK MESIN 3, no. 2 (August 24, 2018): 98–105. http://dx.doi.org/10.52447/jktm.v3i2.1421.
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AbstrakPenelitian ini dilakukan untuk mengetahui pengaruh pompa injeksi bahan bakar tekanan tinggi terhadap kinerja sebuah mesin pada mesin penggerak utama MV. ALAM JAYA II yang menggunakan mesin diesel YANMAR type M22-EN. Berdasarkan data-data yang diperoleh dilapangan, setelah dilakukan pembahasan bahwa tekanan pompa injeksi berpengaruh pada kinerja mesin diesel. Untuk tekanan pompa injeksi sebesar 820 kgf/cm2, kinerja yang dihasilkan mesin adalah : Daya Indikator 1204 kgf/cm2, Daya Efektif 1016 kgf/cm2, Efisiensi Thermal Efektif 32,0% dan konsumsi bahan bakar spesifik sebesar 192 g/hp.h. Sedangkan setelah dilakukan perbaikan pompa injeksi, tekanan pompa menjadi 1120 kgf/cm2, kinerja yang dihasilkan oleh mesin adalah : Daya efektif 1399 hp, Daya Efektif 1195 hp, Efisiensi Thermal Efektif : 37.32%, dan Konsumsi Bahan Bakar Spesifik sebesar 165.7 g/hp.h Dengan adanya perbaikan pompa injeksi sehingga dapat menaikkan tekanan injeksi dari 880 kgf/cm2 menjadi 1120 kgf/cm2, maka kinerja mesin dapat ditingkatkan Kata kunci: mesin diesel,pompa injeksi, kinerja mesin AbstractThis research was conducted to determine the effect of high pressure fuel injection pump on the performance of a machine on the MV main drive engine. ALAM JAYA II which uses the YANMAR type M22-EN diesel engine. Based on the data obtained in the field, after discussion that the injection pump pressure affects the performance of the diesel engine. For injection pump pressure of 820 kgf /cm2, the engine performance is: Indicator Power 1204 kgf /cm2, Effective Power of 1016 kgf /cm2, Effective Thermal Efficiency of 32.0% and specific fuel consumption of 192 g / hp.h. Whereas after the injection pump repairs, the pump pressure becomes 1120 kgf / cm2, the performance produced by the engine is: Effective 1399 hp, Effective 1195 hp, Effective Thermal Efficiency: 37.32%, and Specific Fuel Consumption of 165.7 g / hp. H With the improvement of the injection pump so that it can increase the injection pressure from 880 kgf / cm2 to 1120 kgf /cm2, the engine performance can be improvedKeywords: diesel engine, injection pump, engine performance
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Bow, J. S., M. J. Kim, and R. W. Carpenter. "Comparative Oxidation Studies of Polycrystalline HP and CVD Silicon Carbides by TEM." Proceedings, annual meeting, Electron Microscopy Society of America 49 (August 1991): 938–39. http://dx.doi.org/10.1017/s0424820100089007.
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The excellent oxidation resistance of SiC at high temperature results from formation of a protective SiO2 layer in a strongly oxidizing environment. The oxide layer is often initially amorphous, may transform to a crystalline phase for extended reaction time, especially crystobalite above 1200°C. Our objective is use of high resolution electron microscopy methods to determine the oxide layer microstructure dependence on SiC substrate type, and especially to investigate existence of an intermediate Si-O-C phase between the oxide layer and substrate.
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Bao, Y., Z. Jin, and L. Sun. "Strength degradation and lifetime prediction of HP-Si3N4/TiC under static load at 1200°C." Materials Letters 45, no. 1 (August 2000): 27–31. http://dx.doi.org/10.1016/s0167-577x(00)00069-0.
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Misiuk, Andrzej, Alexander G. Ulyashin, Adam Barcz, and Peter Formanek. "Accumulation of Hydrogen within Implantation-Damaged Areas in Processed Si:N and Si:O." Solid State Phenomena 156-158 (October 2009): 319–24. http://dx.doi.org/10.4028/www.scientific.net/ssp.156-158.319.
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Accumulation of hydrogen in Czochralski silicon implanted with N2+ (Si:N; N dose, DN=1–1.8x1018 cm-2; energy E=140 keV) or O2+ (Si:O; DO=1x1017 cm-2; E=200 keV), processed at up to 1400 K (HT) under enhanced Ar pressure, up to 1.2 GPa (HP), and followed by treatment in hydrogen (deuterium) plasma, was investigated by Secondary Ion Mass Spectroscopy. Implantation produces buried amorphous layer. As determined by transmission electron microscopy, subsequent HT-HP processing results in a formation of a specific sample microstructure. In plasma treated as-implanted Si:N, hydrogen accumulates at a depth of about 50 nm, up to concentration 2x1021 cm-3. This concentration is twice lower at a depth ≈ 80–250 nm. Deuterium content remains almost unchanged after plasma treatment of Si:N prepared by processing at 1270 K while it is strongly dependent on DN and on HP. In plasma treated Si:O, prepared by processing at 920-1230 K, hydrogen profile corresponds to that of implanted oxygen and decreases with HP. Comparative analysis of hydrogen accumulation and its subsequent release at 720-920 K in the Si:N and Si:O structures indicates that the capacity of buried layers in Si:O to getter and to preserve hydrogen is higher than that in Si:N.
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Morishima, SatoKo, Seishi Ogawa, Takakazu Kawase, Aiko Matsubara, Yasuhito Nanya, Koichi Kashiwase, Hiroo Saji, et al. "Impact of Highly Conserved HLA Haplotype on Acute Graft-Versus-Host Disease in Unrelated Bone Marrow Transplantation." Blood 112, no. 11 (November 16, 2008): 59. http://dx.doi.org/10.1182/blood.v112.11.59.59.
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Abstract [INTRODUCTION] Although the effect of HLA locus and/or HLA antigen matching on clinical outcome of unrelated bone marrow transplantation (UR-BMT) has been well characterized, the effect of HLA haplotype (HP) itself is little known. The large scale genotyping of HLA-A, B, C, DRB1, DQB1, DPB1 alleles and SNPs among HLA region by whole genome association scans (WGAS) made it possible to ellucidate conserved common HPs and their impact to acute GVHD in HLA allele matched Japanese patient-donor pairs through Japan Marrow Donor Program. [PATIENTS AND METHODS] 5210 patients who received T cell replete marrow were retrospectively typed for HLA-A, B, C, DRB1, DQB1 and DPB1 allele, and 1810 pairs performed WGAS using Affimetrics 500k array. HLA allele fullmatch was found in 712 pairs, of whom 451 pairs were genotyped 912 SNPs between HLA-A and HLA-DPB2 (from nucleotide 29989443 to 33205942, 3.2Mb). 45 common HLA-A, B, C, DRB1, DQB1, DPB1 HPs among Japanese (designated as HP-P1 to HP-P45) was determined according to the combination of HLA alleles. The probabilities of acute GVHD (grade 2–4) were estimated using the cumulative incidence function, where death without acute GVHD was regarded as a competing risk. Hazard risk (HR) of grade 2–4 acute GVHD was assesed by multivariable Cox regression analysis adjusting with 8 clincal factors. [RESULTS] 1) 220 pairs determined both HPs, 354 one HP, 64 no HP and 74 HP with ambiguility of HP. There was no difference of acute GVHD between these 4 groups (26.7%, 33.2%, 28.6%, 35.8%, respectively). And that, donor and recipient mismatching rate of SNPs was not associated with acute GVHD; less than 5 mismatch SNPs (n=126) showed 32.2%, 6–50 (n=105) 32.4%, 51–100 (n=102) 27.5%, and more than 101 (n=118) 31.4%. 2) Most frequent HP (HP-P1: HLA- A*2402- Cw*1202- B*5201- DRB1*1502- DQB1*0601- DPB1*0901) was found in 331 pairs, and the second HP (HP-P2: HLA-A*3303- Cw*1403- B*4403- DRB1*1302- DQB1* 0604- DPB1*0401) in 111 pairs. 68 out of 72 homozygous HP-P1/P1 individuals had identical homozygous alleles for more than 98% of 912 consecutive SNPs. Of 10 HP-P2/P2 homozygous individuals, all individuals were identical homozygous alleles for 99% of 1310 consecutive SNPs extending from nucleotide 29001906 to 33987897 (4.9 Mb). Further more, 32 out of 34 heterozygous HP-P1/P2 individuals had more than 99% identical consecutive 912 alleles. 3) Considerable number of pairs with HP-P1 made it possible to compare another HPs for the risk of acute GVHD. Notably, 16.2% of acute GVHD in homozygous HP-P1/P1 pair (n=33) and 12.0% of acute GVHD in HP-P1/P2 pair (n=25) were significaitly lower than 39.1% in pair with HP-P1 and HP-P3-45 (n=246) (p=0.01), and HR was 0.41 (p=0.04) and 0.30 (p=0.04) respectively. 4) When analyzed an individual HP, patients with HP-P2 showed significant lower incidence of acute GVHD (22.3% n=111) than HP-P2 negative one (32.7% n=601) (p=0.031), and HR was 0.63 (p=0.032), and the other HPs did no significant difference. [CONCLUSIONS] Donor and recipient mismatching rate of SNPs in HLA region had no correlation with acute GVHD in HLA full matched UR-BMT in JMDP. Common HP-P1 and HP-P2 were highly conserved through HLA-A to HLA-DPB2. Patients with HP-P1/P1 and those with HP-P1/P2 showed lower incidence of acute GVHD, which is compatible with BMT from HLA identical sibling among Japanese. Specific HP (HP-P2)itself reduced the incidence of acute GVHD. These results contribute to favorable outcome of UR-BMT and to ellucidate the mechanism of acute GVHD.
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Turdieva, Sh T., and E. A. Shamansurova. "Features of the endoscopic picture in paediatric gastroduodenal diseases caused by Helicobacter pylori." Russian Journal of Infection and Immunity 10, no. 3 (August 7, 2020): 543–50. http://dx.doi.org/10.15789/2220-7619-fot-1249.
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The aim of the study was to examine the features of the endoscopic picture in the upper digestive tract mucosa in paediatric chronic gastroduodenal pathology (CGDP) associated with Helicobacter pylori. Materials and methods. There were examined 286 patients, aged 6–15 years. Diagnostic criteria for chronic gastroduodenal pathology were anamnestic as well as instrumental and functional studies data: gastric fractional intubation, esophagogastroduodenoscopy (EPGDS) with endoscopic pH-metry without biopsy, and ultrasound examination of abdominal organs. H. pylori testing was carried out by two unrelated methods such as respiratory test and a immunochromatographic fecal test. Results. Detection of H. pylori in children with CGDP peaked in patients with peptic gastric and duodenal ulcer (up to 87.5%, p < 0.05). The main endoscopic signs were edema, hyperaemia and contact bleeding, as well as local haemorrhage were the major endoscopic signs of inflammation in the stomach and duodenum mucosa. Atrophic mucosal lesions were characterized by thinning, pale colour together with transilluminated submucosal vessels. Non-atrophic antral gastritis was featured with delayed gastric emptying, antral stasis and pyloric spasm. In contrast, hypotension of the gastric wall, duodenogastric reflux and decreased motility were more typical to chronic atrophic gastritis. Major endoscopic feature in patients with H. pylori infection was presented by dominant atrophic changes combined with gastroduodenal reflux (77.6%, p < 0.05) compared to patients without H. pylori infection. Conclusion. Detection of HP infection was peaked in children with CGDP coupled to peptic ulcer disease compared to patients with inflammatory diseases (p < 0.05). Endoscopic examination in HP-positive patients showed that atrophic changes were found by 4-fold more frequently together with gastroduodenal reflux compared to patients without HP infection (p < 0.05).
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del Re, Elisabetta C., Victor Zeng, Olivia Lutz, Godfrey Pearlson, John Sweeney, Brett Clementz, Elliot S. Gershon, et al. "O10.6. ANTERIOR VERSUS POSTERIOR HIPPOCAMPUS WITHIN PSYCHOSIS: A BSNIP STUDY." Schizophrenia Bulletin 46, Supplement_1 (April 2020): S26—S27. http://dx.doi.org/10.1093/schbul/sbaa028.060.
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Abstract Background Symptoms of mental diseases can be cross-diagnostic. For example psychosis is not limited to schizophrenia (SZ), but can be also present in bipolar (BPP) and schizoaffective (SA) disorders. Morphometric findings are often also cross-diagnostic, For example, volume decreases of the hippocampus (HP), essential to memory functions, is affected in both schizophrenia and bipolar disorder. Biotyping, grouping of patients according to biomarker-based categories is one attempt to approach cross-diagnostic features in the hope of better classification and ultimately tailored interventions. Here we combine biotyping, in addition to traditional diagnosing, with analysis of the HP volume. Furthermore, we explore the HP according to its anterior (aHP) versus posterior (pHP) anatomical division, following the functional division of this medial temporal lobe structure. Our hypothesis is that aHP and pHP are differentially affected in biotypes and diagnostic groups and reflective of differences in cognitive functions affected in each biotype and/or diagnostic group. Methods The sample included 450 probands (age 35±12.0 yo) and 325 healthy controls (HC; 37±12.0 yo). Of the probands 187 were diagnosed with SZ, 150 with BPP (psychosis type), 113 with SA disorders; after biotyping the same probands were categorized into three biotypes: 118 biotype 1 (BP1), 142 biotype 2 (BP2), 187 biotype 3 (BP3). 3T MRI data were quality checked and processed with FreeSurfer 6.0. The HP measures extracted were: the whole HP, and further HP subfields according to aHP and pHP. aHP and pHP subfields were reconstituted into left and right aHP and pHP. BACS cognitive data and PANSS, SAPS, MADRS and mania clinical ratings were collected. Results Analysis According to Diagnoses: There were no aHP or pHP volume differences among diagnostic groups, but all diagnostic groups demonstrated volume decreases of the left and right aHP compared to HC with effect sizes (Cohen’s d) between 0.3 and 0.6. Further, SA had decreases of the left and right pHP as well and SZ of the left pHP (effect sizes 0.3–0.4) compared to HC. BPP pHP volume were not different than pHP volumes measured in HC. Analysis According to Biotyping: Decreases of left and right aHP and pHP volumes were present in BP1 compared to HC while decreases of left pHP and left and right aHP were present in BT2 compared to HC. Only aHP was affected in BT3 compared to HC. Left and right aHP and pHP distinguished BT1 and BT3. BT1 had further decreased left pHP volume compared to BP2. Several anterior portions of the subfields volumes were driving the aHP vs pHP differences among biotypes while differences of the posterior portions of the subfields were fewer. aHP differences between BP1 and BP2 were driven by the anterior portion of the right subiculum. Discussion Biotypes are more effective than diagnoses in discriminating abnormalities of the HP across psychosis categories. Further, analysis of the aHP versus the pHP demonstrates that the HP should be analyzed not as a whole, or as its subfields, but according to anterior versus posterior divisions of its subfields and to the sum of anterior versus posterior subfields in aHP and pHP. Further studies need to elucidate the cognitive functional correlates of aHP- pHP differences across psychoses and healthy populations.
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MacRae, J. C., L. A. Bruce, F. D. DeB Hovell, I. C. Hart, J. Inkster, A. Walker, and T. Atkinson. "Influence of protein nutrition on the response of growing lambs to exogenous bovine growth hormone." Journal of Endocrinology 130, no. 1 (July 1991): 53–61. http://dx.doi.org/10.1677/joe.0.1300053.
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ABSTRACT Interactions between protein supply and the anabolic response to exogenous bovine (b) GH have been examined in two experiments using 28–35 kg lambs sustained entirely by intragastric infusion of volatile fatty acids (700 kJ/kg W0·75 per day) into the rumen and the casein (600 mg (low protein; LP) or 1200 mg (high protein; HP)/kg W0·75 per day) into the abomasum. Sheep received continuous i.v. infusions of bGH for 6 days in experiment 1 and for 18 days in experiment 2. Nitrogen balances were determined daily throughout both experiments and blood samples, from indwelling catheters, were assayed for GH, insulin-like growth factor-I (IGF-I), insulin and glucose. Infusion of bGH increased plasma GH concentration by five- to sixfold in all animals. There was an increase in N retention in both HP and LP animals over the first 2–3 days of GH administration. HP animals sustained higher N retentions (31%; P < 0·05) throughout the GH administration but LP animals did not. In contrast, plasma IGF-I concentrations increased progressively over the first 72 to 96 h of GH administration in all sheep and thereafter remained significantly (P < 0·05) elevated until termination of the GH infusion. In lambs which received both HP and LP infusions in experiment 1 the increase in IGF-I concentration by day 6 of GH administration was significantly (P < 0·05) greater when they received the higher protein intake. Plasma insulin concentrations increased rapidly (P < 0·05) with the onset of GH administration to levels which were 2·5 (LP)- and 4·8 (HP)-fold greater than those observed in the pre-and post-GH periods. Glucose concentration also increased during GH administration (P < 0·05), by 35% in LP animals and by 58% in HP animals. High protein availability appeared necessary to sustain a protein anabolic response where lambs received exogenous GH infusions, even though plasma IGF-I concentrations were elevated on both high and low protein treatments. Journal of Endocrinology (1991) 130, 53–61
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Alashban, Yazeed, and Nasser Shubayr. "OCCUPATIONAL DOSE ASSESSMENT FOR NUCLEAR MEDICINE AND RADIOTHERAPY TECHNOLOGISTS IN SAUDI ARABIA." Radiation Protection Dosimetry 195, no. 1 (June 2021): 50–55. http://dx.doi.org/10.1093/rpd/ncab112.
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Abstract This study estimated the occupational radiation dose received by nuclear medicine and radiotherapy technologists in Saudi Arabia. A retrospective analysis of personal dosemetry data of 1243 nuclear medicine and radiotherapy technologists from 28 medical centers across Saudi Arabia from 2015 to 2019 was conducted. Thermoluminescent dosemeters were employed to monitor the occupational radiation dose. For the study period, the average annual values for nuclear medicine and radiotherapy technologists were found to be 1.22 mSv (SD = 1.00 mSv) and 0.73 mSv (SD = 0.40 mSv) for Hp(10) and 1.23 mSv (SD = 1.07 mSv) and 0.72 mSv (SD = 0.41 mSv) for Hp(0.07), respectively. The work routines of nuclear medicine technologists cause them to be exposed to higher radiation doses than radiotherapy technologists. The occupational doses for all technologists were found to be below the annual dose limits, which indicates satisfactory working conditions in terms of radiation protection.
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RIBEIRO, Patrícia Fernanda Saboya, Luiz Fernandao KUBRUSLY, Paulo Afonso Nunes NASSIF, Irma Cláudia Saboya RIBEIRO, Andressa de Souza BERTOLDI, and Venessa Caroline BATISTÃO. "RELATIONSHIP BETWEEN ESOPHAGITIS GRADES AND HELICOBACTER PYLORI." ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo) 29, no. 3 (September 2016): 135–37. http://dx.doi.org/10.1590/0102-6720201600030002.
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ABSTRACT Background: The Helicobacter pylori infection (HP) is related to the development of gastric lesions and lymphoma; however, it is not known if there is a relation with gastroesophageal reflux disease and reflux esophagitis. Aim: To evaluate HP's relationship with esophagitis in patients undergoing upper endoscopy. Methods: Observational, retrospective and cross-sectional study, being evaluated 9576 patients undergoing outpatient endoscopic examination during the period between January and December 2015. Were included patients with any esophageal alteration at the examination; greater than 18; of both genders; independent of the complaint or the reason for the examination, illness or drug use. Were excluded those with active bleeding during the examination and in use of anticoagulants. The variables gender, age, esophagitis and result of the urease test, were studied. For statistical analysis was used the Epi Info software 7.1.5.2. Results: Most of the samples consisted of women and the overall average age was 46.54±16.32 years. The presence of infection was balanced for gender: 1204 (12.56%) women and 952 (13.92%) men. Relating degree of esophagitis HP- and HP+ was observed that the type A was the most common (58.79%, n=1460); 604 (24.32%) had grade B; 334 (13.45%) grade C, and 85 (3.42%) grade D. In the relation between the grade of esophagitis with gender, esophagitis A was predominant in women and present in 929 (63.33%), followed by type B, 282 (46.68%), 136 C (40.71%) and D 30 (35.29%). In men 531 (36.36%) showed type A, 322 (53.31%) B, 198 (59.28%) C, and 55 (64.70%) D. Among the groups 40-50 and over 60 years there was a significant difference in whether have or not have HP+. Conclusion: There is no significant difference between HP infection and the different grades of esophagitis.
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Koçkar, Cem, Mustafa Öztürk, and Nüket Bavbek. "Helicobacter Pylori Eradication with Beta Carotene, Ascorbic Acid and Allicin." Acta Medica (Hradec Kralove, Czech Republic) 44, no. 3 (2001): 97–100. http://dx.doi.org/10.14712/18059694.2019.92.
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In this study, in vivo effectiveness of ascorbic acid (AA), beta carotene (BC) and allicin in HP eradication were evaluated. 210 patients who are HP positive in biopsy were involved in this study. The patients randomised to seven treatment groups (each group consisting of 30 patients). The first group was given standard eradication treatment (lansaprasol 30 mg bid, clarithromycin 500 mg bid, amoxicillin 1 g bid for 14 days). Second group received AA 1000 mg/day in addition to the standard treatment. Third group received only AA 1000 mg/day for 14 days. Fourth group was treated with standard regiment plus 120 mg/day BC. Fifth group was given only BC 120 mg/day for 14 days. Sixth group was given standard regiment and allicin 4200 μg/day. Seventh group received only Allicin 1200 μg/day for 14 days. The eradication was achieved in 20 (66.6 %) in group I, 15 (50 %) in group II, 3 (10 %) in group III, 15 (50 %) in group IV, 0 (0 %) in group V, 27 (90 %) in group VI and 7 (23.3 %) in group VII. Allicin seemed to be potentially effective agent for HP eradication but ascorbic acid, beta caroten was found to be ineffective.
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McNeel, Douglas G., Jens C. Eickhoff, Laura E. Johnson, Alison R. Roth, Timothy G. Perk, Lawrence Fong, Emmanuel S. Antonarakis, Ellen Wargowski, Robert Jeraj, and Glenn Liu. "Phase II Trial of a DNA Vaccine Encoding Prostatic Acid Phosphatase (pTVG-HP [MVI-816]) in Patients With Progressive, Nonmetastatic, Castration-Sensitive Prostate Cancer." Journal of Clinical Oncology 37, no. 36 (December 20, 2019): 3507–17. http://dx.doi.org/10.1200/jco.19.01701.
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PURPOSE We previously reported the safety and immunologic effects of a DNA vaccine (pTVG-HP [MVI-816]) encoding prostatic acid phosphatase (PAP) in patients with recurrent, nonmetastatic prostate cancer. The current trial evaluated the effects of this vaccine on metastatic progression. PATIENTS AND METHODS Ninety-nine patients with castration-sensitive prostate cancer and prostate-specific antigen (PSA) doubling time (DT) of less than 12 months were randomly assigned to treatment with either pTVG-HP co-administered intradermally with 200 μg granulocyte-macrophage colony-stimulating factor (GM-CSF) adjuvant or 200 μg GM-CSF alone six times at 14-day intervals and then quarterly for 2 years. The primary end point was 2-year metastasis-free survival (MFS). Secondary and exploratory end points were median MFS, changes in PSA DT, immunologic effects, and changes in quantitative 18F-sodium fluoride (NaF) positron emission tomography/computed tomography (PET/CT) imaging. RESULTS Two-year MFS was not different between study arms (41.8% vaccine v 42.3%; P = .97). Changes in PSA DT and median MFS were not different between study arms (18.9 v 18.3 months; hazard ratio [HR], 1.6; P = .13). Preplanned subset analysis identified longer MFS in vaccine-treated patients with rapid (< 3 months) pretreatment PSA DT (12.0 v 6.1 months; n = 21; HR, 4.4; P = .03). PAP-specific T cells were detected in both cohorts, including multifunctional PAP-specific T-helper 1–biased T cells. Changes in total activity (total standardized uptake value) on 18F-NaF PET/CT from months 3 to 6 increased 50% in patients treated with GM-CSF alone and decreased 23% in patients treated with pTVG-HP (n = 31; P = .07). CONCLUSION pTVG-HP treatment did not demonstrate an overall increase in 2-year MFS in patients with castration-sensitive prostate cancer, with the possible exception of a subgroup with rapidly progressive disease. Prespecified 18F-NaF PET/CT imaging conducted in a subset of patients suggests that vaccination had detectable effects on micrometastatic bone disease. Additional trials using pTVG-HP in combination with PD-1 blockade are under way.
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Zeng, Ling-Hua, Jun Wu, Beverly Fung, Jeffrey H. Tong, Donald Mickle, and Tai-Wing Wu. "Comparative protection against oxyradicals by three flavonoids on cultured endothelial cells." Biochemistry and Cell Biology 75, no. 6 (December 1, 1997): 717–20. http://dx.doi.org/10.1139/o97-062.
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Oxygen-derived free radicals are known to injure the endothelium of aorta in diverse disorders. In this study we compared the cytoprotective effects of three flavonoids against oxyradical damage to porcine aortic endothelial cells in vitro. Cultured porcine aortic endothelial cells were exposed to oxyradicals generated by xanthine oxidase - hypoxanthine (XO-HP). The cytoprotective activities of morin, quercetin, and catechin on these systems were compared using established morphologic criteria. The results in the XO-HP system showed that morin at 0.125, 0.25, and 0.5 mM delayed cell necrosis to 27.4 ± 1.3, 46.8 ± 1.8, and longer than 70 min, respectively, compared with 12.0 ± 1.3 min in the control group. These degrees of protection were significantly stronger than those provided by quercetin and catechin at corresponding concentrations (p < 0.01). Morin and quercetin were moderate inhibitors of xanthine oxidase on the basis of the oxygen consumption rate, whereas catechin at the same concentrations had little inhibitory effect. The data from uric acid formation and cytochrome c reduction were consistent with the oxygen consumption measurement for the three flavonoids. Key words: flavonoids, oxyradicals, aortic endothelial cells.
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Andreeff, M., J. Mielcarek, I. Barth, G. Wunderlich, J. Kropp, J. Kotzerke, and K. Liepe. "Beta-radiation exposure at the finger tips during the radionuclide synovectomy." Nuklearmedizin 42, no. 03 (2003): 104–8. http://dx.doi.org/10.1055/s-0038-1625306.
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ZusammenfassungZiel: Der Anstieg der Therapiezahlen bei der Radio-synoviorthese (RSO) und die neue Strahlenschutzverordnung (StrSchV) erfordern, die -Strahlenbelastung, HP(0,07), des Personals bei der RSO zu dokumentieren. Methode: Da die amtlichen Teilkörperdosimeter (TLDFingerringdosimeter) die -Strahlenbelastung bei der RSO ungenügend wiedergeben, wurden Thermolumineszenzdosimeter (TLD) auf allen Fingerkuppen des Therapeuten, Radiochemikers und der assistierenden Schwester platziert. An 6 Therapietagen mit insgesamt 155 behandelten Gelenken erfolgte die Messung der HP(0,07) für die Nuklide 169Er, 186Re, 90Y. Ergebnisse: Die höchste Dosis zeigten linker Zeigefinger- (ZF li.) und Daumenkuppe (Daumen li.) des Therapeuten (Rechtshänder). Für drei Therapiesitzungen mit 52 Finger- (1204 MBq 169Er), 31 großen Gelenken (2405 MBq 186Re) sowie 15 Kniegelenken (3100 MBq 90Y) betrug die kumulative Dosis für den ZF li. 190 mSv , für den Daumen li. 48 mSv. Als maximale Ortsdosen ergeben sich: 0,56 Sv/MBq (169Er) bzw. 1,52 Sv/MBq (186Re) am ZF li. Durch Einsatz eines Manipulators für die Fixierung der Injektionsnadel konnte die Fingerbelastung für 90Y am li. ZF von 22,09 auf 0,42 Sv/MBq reduziert werden. Die kumulative Fingerbelastung betrug 119 mSv am Daumen li. (Radiochemiker) und 16 mSv am ZF li. (Assistenz). Schussfolgerung: Bei üblicher Durchführung der RSO wird der größte Teil der HP(0,07) durch 90Y verursacht. Besonders am ZF li. besteht die Gefahr, den Grenzwert der Organdosis für die Haut §55 StrlSchV zu überschreiten. Mit einem Manipulator zur Fixierung der Injektionsnadel kann die maximale Fingerbelastung um den Faktor 50 reduziert und der gesetzlich vorgeschriebene Grenzwert eingehalten werden.
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Guo, Jingyi, Guangdeng Chen, Xizhou Zhang, Tingxuan Li, Haiying Yu, and Chunji Liu. "Quantitative trait locus analysis of adventitious and lateral root morphology of barley grown at low and high P." Functional Plant Biology 45, no. 9 (2018): 957. http://dx.doi.org/10.1071/fp17271.
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Barley (Hordeum vulgare L) may alter its root morphology to improve P acquisition efficiency under low-P (LP) stress. This research studied the variations in adventitious and lateral root morphological traits of barley and mapped their quantitative trait loci (QTLs) under LP and high P (HP). The recombinant inbred lines were derived from the F1 population of a cross between CN4027 and Baudin. Two experiments aimed to identify QTLs related to adventitious and lateral root morphological traits under LP and HP. The length, surface area and volume of adventitious and lateral roots were measured. Under HP, Baudin had larger root morphology, especially lateral root morphology, than CN4027. LP stress induced lateral root growth but inhibited adventitious root growth. Nineteen QTLs for root morphological traits were detected. These QTLs clustered within four regions (Cl−2H, Cl−3H, Cl−4H and Cl−7H) on chromosomes 2H, 3H, 4H and 7H, with corresponding contributions of 12.0–42.9%. Some QTLs are linked with the QTLs for P efficiency detected previously, demonstrating the role of root morphological traits in P efficiency. The Cl−2H region was identified in the interval bPb3927665–bPb3265744 on chromosome 2H and had major effects on lateral root growth, especially under LP. Lateral root length and surface area increased when alleles from Baudin were present at the QTLs in Cl−2H. This study demonstrated the patterns of growth among root types and the role of lateral roots in barley’s adaption to LP stress. The QTL clusters, especially Cl−2H, may offer clues for fine mapping and map-based cloning.
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Park, Ji Yeon, Seok Min Kang, Weon Ju Kim, and Akira Kohyama. "Characterization of MeV Ion-Irradiated SiCf/SiC Composites Prepared with Different Methods." Advanced Materials Research 59 (December 2008): 257–62. http://dx.doi.org/10.4028/www.scientific.net/amr.59.257.
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To estimate the ion-irradiation effect on various types of SiCf/SiC composites, a silicon self-ion irradiation was performed at temperatures of 600 °C and 1200 °C and at doses of 5 dpa and 20 dpa, respectively. These SiCf/SiC composites were prepared by different processes such as CVI (chemical vapor infiltration), WA-CVI (SiC whisker assisted CVI) and hot-pressing (HP) method. Hardness was measured by a nano-indentation tester and microstructural changes were observed by TEM with SAD(selected area diffraction) technique for the specimens prepared by FIB (Focused Ion Beam) milling. The damage dose was calculated by the SRIM2003 code and then compared with microstructureal observation.
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Virk, Sohrab, Avani S. Vaishnav, Jung Kee Mok, Steven McAnany, Sravisht Iyer, Todd J. Albert, Catherine Himo Gang, and Sheeraz A. Qureshi. "How do high preoperative pain scores impact the clinical course and outcomes for patients undergoing lumbar microdiscectomy?" Journal of Neurosurgery: Spine 33, no. 6 (December 2020): 772–78. http://dx.doi.org/10.3171/2020.5.spine20373.
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OBJECTIVEPreoperative pain assessment is often used to gauge the amount of disability in patients with lumbar disc herniation. How high preoperative pain scores impact the clinical course and outcomes of patients after lumbar microdiscectomy is not always clear. Here, the authors aimed to determine whether patients reporting higher preoperative pain scores have worse outcomes after lumbar microdiscectomy than those reporting lower preoperative scores.METHODSThe authors performed a retrospective review of patients with symptomatic lumbar disc herniations that had failed to improve with nonsurgical methods and who had undergone tubular lumbar microdiscectomy. Health-related quality of life (HRQOL) scores had been collected in the preoperative and postoperative period. The anatomical severity of disease was graded based on lumbar disc health (Pfirrmann classification), facet degeneration, thecal sac cross-sectional area, and disc herniation grade. Data on each patient’s narcotic consumption and length of stay were collected. A Student t-test and chi-square test were used to compare patients with high preoperative pain scores (HP cohort) and those with lower preoperative scores (non-HP cohort).RESULTSOne hundred thirty-eight patients were included in this analysis. The 47 patients in the HP cohort had taken more preoperative opioids (12.0 ± 21.2 vs 3.6 ± 11.1 morphine equivalent doses, p = 0.01). However, there was no statistically significant difference in Pfirrmann classification (p > 0.15), facet grade (p > 0.11), thecal sac cross-sectional area (p = 0.45), or disc herniation grade (p = 0.39) between the HP and non-HP cohorts. The latter cohort had statistically significant higher preoperative PROMIS scores (36.5 ± 7.0 vs 29.9 ± 6.4, p < 0.001), SF-12 mental component summary scores (48.7 ± 11.5 vs 38.9 ± 16.1, p < 0.001), and SF-12 physical component summary scores (PCS; 32.4 ± 8.6 vs 27.5 ± 10.0, p = 0.005), but a lower Oswestry Disability Index (56.4 ± 22.1 vs 35.4 ± 15.5, p < 0.001). There were only two time points after microdiscectomy when the HP cohort had worse HRQOL scores: at the 2-week follow-up for SF-12 PCS scores (32.4 ± 8.6 vs 29.3 ± 7.1, p = 0.03) and the 12-week follow-up for PROMIS scores (45.2 ± 9.5 vs 39.5 ± 7.1, p = 0.01). All other postoperative HRQOL measurements were similar between the two cohorts (p > 0.05).CONCLUSIONSA patient’s perceived severity of disease often does not correlate with the actual clinical pathology on imaging. Although patients who report high pain and have a symptomatic lumbar disc herniation may describe their pain as more extreme, they should be counseled that the outcomes of microdiscectomy are positive.
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Kort, Rachel, Haley Wecker, Chance Fiehler, Aundria Ogles, Jared Froetschner, Charles R. Stark, and Chad B. Paulk. "PSI-11 Moisture Content Throughout the Pelleting Process and Subsequent Effects on Pellet Quality." Journal of Animal Science 98, Supplement_3 (November 2, 2020): 228–29. http://dx.doi.org/10.1093/jas/skaa054.399.
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Abstract This experiment was designed to evaluate the effects of steam addition to the conditioner on moisture content throughout the pelleting process and subsequent effects on pellet quality. Treatments consisted of diets pelleted with no steam and steam added to achieve conditioning temperatures of 62.8 and 87.8°C. Conditioner retention time was set at 30 sec and diets were pelleted with a 6.4×63.5 mm pellet die. Pellet samples were collected and immediately placed in an experimental counter-flow cooler for 15 min. All treatments were replicated at 3 separate time points to provide 3 replicates per treatment. Mash (M), conditioned mash (CM), hot pellets (HP), and cooled pellet (CP) samples were collected for moisture content analysis and CP for pellet durability index (PDI). Data were analyzed with pelleting run as the experimental unit and time period as the blocking factor. Moisture samples were analyzed as a 3×4 factorial of steam-conditioning and sample location. There was a steam-conditioning×sample interaction (P< 0.01) for moisture. Mash samples for all treatments were similar (13.3%; 36.2°C). For the no steam treatment, there was no difference in moisture content for the M, CM, and HP; however, moisture decreased in CP, with samples having 13.4, 13.1, 12.9, and 12.0% moisture, respectively. For the 62.7°C treatment, there was an increase in moisture from M to CM, followed by a decrease in both HP and CP, with samples having 13.2, 15.3, 14.9, and 12.7% moisture, respectively. For the 87.8°C treatment, moisture increased from M to CM, and decreased in HP and CP with samples having 13.3, 17.3, 16.3, and 13.4% moisture, respectively. Increasing conditioning temperature from no steam to 87.8°C increased (P< 0.01) PDI from 3.3, 59.1, to 91.1%, respectively. In conclusion, increasing feed temperature from 36.2 to 87.8°C via steam addition increased condition mash moisture content by 4.2% resulting in improved pellet quality.
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Iyengar, Neil M., Lillian Mary Smyth, Diana Lake, Ayca Gucalp, Jasmeet Chadha Singh, Tiffany A. Traina, Patricia Anne DeFusco, et al. "Phase II study of gemcitabine (G), trastuzumab (H), and pertuzumab (P) for HER2-positive metastatic breast cancer (MBC) after prior pertuzumab-based therapy." Journal of Clinical Oncology 35, no. 15_suppl (May 20, 2017): 1037. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.1037.
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1037 Background: The combination of taxanes with HP for first line treatment of HER2-positive MBC is associated with improved progression-free (PFS) and overall survival (OS). Treatment per physician’s choice with anti-HER2 therapy after second line therapy is associated with a median PFS of 3 months. While continued use of H in therapeutic combinations after progression on H-based therapy is standard, the efficacy of continuing HP-based treatment after progression on P-based therapy is unknown. Methods: This is a single arm phase II trial of G with HP. Eligible patients (pts) had HER2-positive (IHC 3+ or FISH > 2.0) MBC with prior HP-based treatment and ≤ 3 prior chemotherapies. Pts received G (1200 mg/m2) on days 1 and 8 of a q 3 week (w) cycle, and H (8 mg/kg load → 6 mg/kg) and P (840 mg load → 420 mg) q3w. The primary endpoint is PFS at 3 months. Secondary endpoints include OS, safety and tolerability. An exploratory endpoint is to compare PFS by RECIST criteria versus 18-F FDG-PET response criteria. The study therapy will be considered successful if at least 27/45 (60%) patients are progression free at 3 months. Results: As of 1-27-17, 41 of 45 pts are enrolled; 34 are evaluable at 3 months and 7 have not had 3-month evaluation. At 3 months, 26/34 (76%) are progression free (1 CR, 8 PR, 17 SD); 8 pts progressed. There are no cardiac or febrile neutropenic events to date. 4 pts required G dose reduction (3 grade 3 neutropenia and 1 grade 3 vomiting) and the study was amended to lower initial G dose to 1000 mg/m2. Conclusions: The preliminary 3 month-PFS is 76% in evaluable pts (95% CI 60% to 88%). The updated 3 month-PFS results will be presented. Continuation of P beyond progression is associated with apparent clinical benefit. A randomized trial is justified to confirm this clinically important observation. Clinical trial information: NCT02252887.
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Song, Yang, Chang An Wang, Chun Qing Peng, and Yong Huang. "Fabrication and Mechanical Properties of High-Pure Ti3SiC2 Bulk Materials Directly by Hot-Pressing its Powder." Key Engineering Materials 336-338 (April 2007): 958–60. http://dx.doi.org/10.4028/www.scientific.net/kem.336-338.958.
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High-pure bulk Ti3SiC2 samples were fabricated by directly hot-pressing (HP) high-pure Ti3SiC2 powder without any additives at 1200°C to 1500°C for 0.5–2 hours in flow argon atmosphere. X-ray diffraction (XRD) and scanning electron microscope (SEM) were used for phase identification and microstructure evaluation. The fabricated Ti3SiC2 materials have relative high density with high purity, flexural strength of 500-700MPa and fracture toughness of 9-12MPa·m1/2. The influence of sintering temperature and soaking time on the mechanical properties of Ti3SiC2 materials was discussed. The sintering mechanism for Ti3SiC2 powder without any additives was considered to be related with the fragile-ductile transformation of Ti3SiC2 at 1100°C.
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Schertl, Hans-Peter, Andreas Hertwig, and Walter V. Maresch. "Cathodoluminescence Microscopy of Zircon in HP- and UHP-Metamorphic Rocks: A Fundamental Technique for Assessing the Problem of Inclusions versus Pseudo-Inclusions." Journal of Earth Science 30, no. 6 (October 31, 2019): 1095–107. http://dx.doi.org/10.1007/s12583-019-1246-5.
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Nhien, Le Cao, Nguyen Van Duc Long, and Moonyong Lee. "Novel Heat-Integrated Hybrid Distillation and Adsorption Process for Coproduction of Cellulosic Ethanol, Heat, and Electricity from Actual Lignocellulosic Fermentation Broth." Energies 14, no. 12 (June 8, 2021): 3377. http://dx.doi.org/10.3390/en14123377.
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Cellulosic ethanol (CE) can not only be produced from a nonedible, cheap, and abundant lignocellulose feedstock but also can reduce carbon footprint significantly compared to starch ethanol. Despite great stimulation worldwide, CE production has not yet commercialized because of the complexity of lignocellulose. Therefore, intensive research and development are needed to improve CE technologies. In this study, a cost-efficient and sustainable design was proposed for the coproduction of CE, heat, and electricity from the actual lignocellulosic fermentation broth. First, a conventional coproduction process of CE, heat, and electricity based on hybrid distillation and adsorption (HDA) was simulated and optimized. Subsequently, various heat integrated (HI) techniques such as heat pump (HP), multi-effect distillation (MED), and combined HP-MED were evaluated to improve the CE process. The combined heat and power (CHP) process that utilized the combustible solids of the beer stillage was designed and integrated with the CE process. Structural alternatives were assessed for both economic and environmental impacts. The results show that the proposed HI-HDA process can save 36.9% and 33.6% of total annual costs and carbon footprint, respectively, compared to the conventional CE process. In the proposed HI-HDA coproduction process, the CE recovery process can be self-efficient in energy and the CHP can generate 12.0% more electricity than that in the conventional coproduction process.
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Jaworska, L., Jerzy Morgiel, Ludosław Stobierski, Jerzy Lis, B. Krolicka, and W. Maziarz. "Molybdenum Silicides as a Bonding Phase in Diamond Composites." Materials Science Forum 498-499 (November 2005): 587–93. http://dx.doi.org/10.4028/www.scientific.net/msf.498-499.587.
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Molybdenum silicides were obtained by the self-propagating synthesis (SHS) method. Diamond composites containing 30 mass% of MoSi2 or Mo5Si3 bonding phase had been prepared using HT-HP Bridgman type apparatus. Sintering of the diamond composites were carried out at 2073±50 K and 8±0.2 GPa. The interactions in diamond-silicide composites were studied by means of X-ray diffractometry and transmission electron microscopy (TEM). Results of both mechanical properties and thermal resistance measurements are reported. Hardness HV1 for the composite with the predominantly MoSi2 bonding phase was found to be around 42 GPa. After heat treatment in 1200 °C for 30 min. in vacuum HV1 decreases to 29 GPa. In the second composite containing the Mo5Si3 bonding phase the HV1 of 28.0 GPa after thermal exposure changes to 21.0 GPa.
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Rudar, Marko, Daniel A. Columbus, Julia Steinhoff-Wagner, Agus Suryawan, Hanh V. Nguyen, Ryan Fleischmann, Teresa A. Davis, and Marta L. Fiorotto. "Leucine Supplementation Does Not Restore Diminished Skeletal Muscle Satellite Cell Abundance and Myonuclear Accretion When Protein Intake Is Limiting in Neonatal Pigs." Journal of Nutrition 150, no. 1 (September 13, 2019): 22–30. http://dx.doi.org/10.1093/jn/nxz216.
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ABSTRACT Background Rapid growth of skeletal muscle in the neonate requires the coordination of protein deposition and myonuclear accretion. During this developmental stage, muscle protein synthesis is highly sensitive to amino acid supply, especially Leu, but we do not know if this is true for satellite cells, the source of muscle fiber myonuclei. Objective We examined whether dietary protein restriction reduces myonuclear accretion in the neonatal pig, and if any reduction in myonuclear accretion is mitigated by restoring Leu intake. Methods Neonatal pigs (1.53 ± 0.2 kg) were fitted with jugular vein and gastric catheters and fed 1 of 3 isoenergetic milk replacers every 4 h for 21 d: high protein [HP; 22.5 g protein/(kg/d); n= 8]; restricted protein [RP; 11.2 g protein/(kg/d); n= 10]; or restricted protein with Leu [RPL; 12.0 g protein/(kg/d); n= 10]. Pigs were administered 5-bromo-2’-deoxyuridine (BrdU; 15 mg/kg) intravenously every 12 h from days 6 to 8. Blood was sampled on days 6 and 21 to measure plasma Leu concentrations. On day 21, pigs were killed and the longissimus dorsi (LD) muscle was collected to measure cell morphometry, satellite cell abundance, myonuclear accretion, and insulin-like growth factor (IGF) system expression. Results Compared with HP pigs, postprandial plasma Leu concentration in RP pigs was 37% and 47% lower on days 6 and 21, respectively (P < 0.05); Leu supplementation in RPL pigs restored postprandial Leu to HP concentrations. Dietary protein restriction reduced LD myofiber cross-sectional area by 21%, satellite cell abundance by 35%, and BrdU+ myonuclear abundance by 25% (P < 0.05); Leu did not reverse these outcomes. Dietary protein restriction reduced LD muscle IGF2 expression by 60%, but not IGF1 or IGF1R expression (P < 0.05); Leu did not rescue IGF2 expression. Conclusions Satellite cell abundance and myonuclear accretion in neonatal pigs are compromised when dietary protein intake is restricted and are not restored with Leu supplementation.
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Graham, David Y., Yamil Canaan, James Maher, Gregory Weiner, and Ira N. Kalfus. "1200 Rifabutin (RHB-105) Based Triple Therapy for Helicobacter pylori (HP) Infection Eradication: Results of Pivotal Phase 3 Multi-Center Study (ERADICATE Hp2)." American Journal of Gastroenterology 114, no. 1 (October 2019): S674. http://dx.doi.org/10.14309/01.ajg.0000594328.47553.95.
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Khien, Nguyen Van, Vu Dinh Lam, and Le Van Hong. "Ba\(_{1-x}\)Ca\(_{x}\)TiO\(_{3}\) and the Dielectric Properties." Communications in Physics 24, no. 2 (June 4, 2014): 170. http://dx.doi.org/10.15625/0868-3166/24/2/3870.
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Ba1-xCaxTiO3 material samples with x changing from zero to 1 were fabricated by the solid state reaction method at a temperature of 1200 oC in the ambient atmosphere. Crystalline structure of the material samples was recorded and identified by X-ray diffraction and Raman scattering. Analyzing the X-ray patterns found that Ba can be completely substituted by Ca with the concentration lower than 11 at%. The frequency dependence of the impedance (C) and AC conductance (G) of all the samples were recorded in a frequency range lower than 10 MHz by using an impedance analyzer HP 4192A. It was found that in the low frequency range lower than 1 MHz the dielectric constant and its loss decrease as Ca substituted for Ba. Besides an abnormal in the frequency dependence of the dielectric constant was observed for all samples in the higher frequency range up to 10 MHz.
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Zalat, O. A., Mohamed A. Elsayed, M. S. Fayed, and M. K. Abd El Megid Megid. "Sources of Uncertainty for the Determination of Chlorpyrifos by Gas Chromatography Equipped with Flame Photometric Detector." International Letters of Chemistry, Physics and Astronomy 25 (January 2014): 48–55. http://dx.doi.org/10.18052/www.scipress.com/ilcpa.25.48.
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Analysts are increasingly being required to evaluate the uncertainty associated with methods. Estimating the uncertainty of an analytical result is an essential part of quantitative analysis. This paper discusses the sources of uncertainty of chlorpyrifos determination by gas chromatography equipped with flame photometric detector (GC-FPD). The analysis was performed on HP-5 MS, 30 m x 0.32 mm capillary column with a 0.25 μm stationary film thickness using ultra pure nitrogen (99.9999%) as a carrier gas at 25 psi constant pressure. The method has been optimized. Factors affecting quantization of chlorpyrifos such as injector temperature, carrier gas inlet pressure, air to hydrogen ratios and initial temperature program have been studied to get the best sensitivity, minimum delectability. The liner range of the detector was from 0.15 ng/ml to 1200 ppm, the minimum detection limit was 0.15 ng/ml and the relative standard deviation was 0.839.
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Philips, J. C., J. W. Miller, W. C. Wernau, B. E. Tate, and M. H. Auerbach. "A High-Pyruvate Xanthan for EOR." Society of Petroleum Engineers Journal 25, no. 04 (August 1, 1985): 594–602. http://dx.doi.org/10.2118/10617-pa.
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Abstract High-pyruvate xanthan (HP xanthan) is produced by a proprietary strain of the Xanthomonas campestris proprietary strain of the Xanthomonas campestris organism and is available in the form of a 3 to 5 % broth or a 12 to 15 % concentrate. The liquid product is supplied commercially (FLOCON 4800 or 4800C (TM) from Pfizer Inc.) for use as a mobility control and Pfizer Inc.) for use as a mobility control and permeability reduction agent for micellar, water-thickened, and permeability reduction agent for micellar, water-thickened, and waterflood diversion projects. This paper deals with use of the product for mobility control. The biopolymer is similar in structure to other commercial xanthans but contains a significantly higher level of ketal-bound pyruvic acid. Assay methods, including those applicable pyruvic acid. Assay methods, including those applicable to field waters, are discussed. While dilute HP xanthan exhibits viscosity/ concentration profiles and pH sensitivities that are similar to other xanthans, it has superior tolerance to high levels of salinity and hardness. Injectivity, as measured by Millipore TM filtration, is not adversely affected by high levels of monovalent cations and magnesium ion. The presence of ferric ion produces severe filterability presence of ferric ion produces severe filterability deterioration, while problems with calcium and ferrous ions are less serious. Good filterability in the presence of iron or hardness cations is restored by use of certain chelating agents and surfactants. Sequential filtrations of HP xanthan and other xanthans have been carried out with various-size Millipore membranes. On this basis, the effective size of the HP-xanthan molecule was shown to be no larger than 0.2 mu m. Compatibilities of HP xanthan with biocities, oxygen scavengers, and surfactants are discussed, as is information demonstrating control of microbiological problems and field propagation of the biopolymer. Introduction Activity among U.S. petroleum producers in EOR has increased significantly in recent years as a result of windfall profit tax incentives and the increasing number of waterflooded reservoirs that are approaching the limits of economic viability. Xanthan gums and hydrolyzed polyacrylamides have been used for mobility control in polyacrylamides have been used for mobility control in nearly all chemical flood projects to date. The choice between polyacrylamide and xanthan for EOR depends on a number of factors. Both polymers require a biocide to ensure protection against microbial attack. Although xanthan is more expensive than polyacrylamide, it offers outstanding resistance to shear polyacrylamide, it offers outstanding resistance to shear degradation that is troublesome for polyacrylamides in low-permeability formations. Also, in contrast to polyacrylamides, xanthan is retained to a lesser extent on polyacrylamides, xanthan is retained to a lesser extent on formation rock and is largely insensitive to waters with high salt content. A significant percentage of fields targeted for future EOR processes contain brine of high salinity and/or high hardness; and with growing restrictions on freshwater supplies, field brines will be used increasingly as injection fluids. Early injectivity problems associated with solutions of solid xanthan have been alleviated through the use of readily diluted liquid products. products. HP xanthan is available commercially as a liquid broth or concentrate. Rheological and injectivity properties of the biopolymer, as they relate to mobility control, are discussed. Xanthan Structures Xanthan contains D-glucose, D-mannose, and D-glucuronic acid in the repeating pentasaccharide unit shown in Fig. 1. In addition to the constituent sugars, acetate groups and pyruvic acid ketals are found in the side chains, and it has been reported that xanthan rheological properties are dramatically affected by pyruvate content. Table 1 shows pyruvic acid content as pyruvate content. Table 1 shows pyruvic acid content as a function of the percent of side chains bearing the pyruvate ketal moiety. HP xanthan is unique among pyruvate ketal moiety. HP xanthan is unique among xanthans in that most of the side chains contain this functionality, with the resulting pyruvic acid content being approximately twice that of commercial solid xanthan. Broth Properties Broth viscosities, as a function of concentration (activity basis), for HP xanthan and a conventional xanthan broth are shown in Fig. 2. HP-xanthan broth has a distinctly lower viscosity than conventional broth, and at concentrations of 0.1% or higher, it exhibits substantially lower yield points. These factors enable more efficient mass transfer during the fermentation process and permit production of a higher-assay broth. production of a higher-assay broth. An aqueous concentrate of 12 to 15 % xanthan, which offers further improved economics by significant reduction in shipping costs, is now available commercially. While more viscous than broth (Brookfield viscosity 12,000 to 13,500 cp [12.0 to 13.5 Pas], No. 4 spindle, 30 rev/min), the concentrate flows smoothly and is readily pumped and diluted with the same field equipment used for handling the normal 3 to 5 % broth. SPEJ P. 594
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Lemos, Joice Ribeiro, Larissa De Oliveira Rosa Marques, Ana Karoline Silva Oliveira, Xisto Sena Passos, Juliana Menara de Souza Marques, Milton Camplesi Junior, Mônica Santiago Barbosa, Antonio Márcio Teodoro Cordeiro Silva, and Lucas Luiz de Lima Silva. "Genes de virulência e polimorfismos gênicos ligados à suscetibilidade à infecção por Helicobacter pylori." Saúde em Revista 20, no. 52 (December 17, 2020): 119–30. http://dx.doi.org/10.15600/2238-1244/sr.v20n52p119-130.
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Introdução: Helicobacter pylori (H.pylori) é um bacilo espiralado gram negativo capaz de induzir inflamação persistente na mucosa gástrica com diferentes lesões, tais como gastrite crônica, úlcera péptica e câncer gástrico. Porém, a infecção não necessariamente induz a patogenia gastrointestinal, para isso tem-se a influência dos fatores de virulência e patogenicidade. Objetivos: Descrever os principais genes de virulência da ilha de patogenicidade e plasticidade e os principais polimorfismos gênicos do sistema imunológico do hospedeiro e correlaciona-los com lesões causadas pela infecção por H. pylori. Métodos: Trata-se de uma revisão da literatura sobre os polimorfismos gênicos do sistema imune do hospedeiro e genes de virulência ligados à suscetibilidade à infecção por H. pylori através de pesquisas a fim de identificar evidências relevantes. A coleta de dados foi realizada nas bases de dados Lilacs, SciELO, Medline, no site do NCBI e na base de dados PubMed. Resultados: Os genes da ilha de patogenicidade (cagPAI) são: cagA, vacA, babA, hp-nap, cagE, iceA, cagG, virB11 e virD4; os genes da ilha de plasticidade são dupA, sabA e oipA. Os polimorfismos do sistema imune do hospedeiro que estão associados à infecção por H. pylori são: IL-6, IL-8, IL-1β, TNF-α e IL-10. As doenças gastrointestinais relacionadas à H. pylori, seus genes de virulência e os polimorfismos gênicos imunológicos são: atrofia gástrica, gastrite crônica, úlcera gástrica, úlcera duodenal e carcinoma gástrico. Conclusão: Cepas de H. pylori distintas apresentam genes de virulência diferentes, desencadeando resposta imune com diferentes intensidades, provocando doenças gastrointestinais diferentes.
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Moravcikova-Gouvea, Larissa, Zuzana Kovacova, Michael Kitzmantel, Erich Neubauer, Vít Jan, and Ivo Dlouhy. "Influence of Hot Pressing Sintering Temperature on the Properties of Low-Density Al0.5NbTa0.8Ti1.5V0.2Zr Refractory High-Entropy Alloy." Materials Science Forum 1016 (January 2021): 940–45. http://dx.doi.org/10.4028/www.scientific.net/msf.1016.940.
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In this work, the low-density Al0.5NbTa0.8Ti1.5V0.2Zr RHEA prepared by mechanical alloying combined with hot uniaxial pressing (HP) was investigated. The alloy was subjected to different sintering temperatures on the range of 1200°C up to 1600°C, while keeping a constant densification time. The influence of the increase in sintering temperatures on the RHEAs’ microstructural features, composition and basic mechanical properties was explored by means of x-ray diffraction and scanning electron microscopy, hardness testing, density determination by Archimedes’ principle and elastic moduli by ultrasonic measurements. Full density samples were obtained in all sintering temperatures. The alloy has shown a homogeneous distribution of phases, with presence of dispersed oxides inside the matrix, leading to a fine grain size distribution due to grain-boundary pinning effect, even during the exposure of the alloy at the highest sintering temperature. The mentioned effect is responsible for the achievement of high-hardness in all conditions. Powder metallurgy has been shown to be an advantageous technique for production of alloys for high-temperature applications, as the inherent in-situ formed oxides homogeneously distributed within the matrix may be beneficially used as reinforcement, thus potentially enhancing the mechanical properties of the parts.
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Calvert, Emma, Bradley P. Wynne, and Martin Jackson. "Exploitation of Field-Assisted Sintering Technology (FAST) to Produce Pre-Forged Billets from Metastable Beta Titanium Alloy Powder." Key Engineering Materials 716 (October 2016): 800–816. http://dx.doi.org/10.4028/www.scientific.net/kem.716.800.
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Powder produced by gas atomisation of metastable beta alloy Ti-5Al-5Mo-5V-3Cr has been consolidated using field-assisted sintering technology (FAST) to examine the suitability of the process to produce pre-forged billets as opposed to the conventional multi-step Kroll-VAR-forging route. FAST testing was performed using an FCT Systeme GmbH spark plasma sintering furnace type HP D 25 at The University of Sheffield. The dwell temperature was varied between 800 and 1200°C and the dwell time between 3 and 60 minutes. The process was found to allow very precise control over the beta grain size in Ti-5Al-5Mo-5V-3Cr by variation of the dwell time and dwell temperature, producing grain sizes between ~40 and ~350 μm. However, it was found that the grain size was increased more by increasing the dwell temperature than increasing the dwell time. The porosity was found to be between 99.5 and 100 % for all dwell temperatures at dwell times of 30 minutes or above. FAST has the ability to produce almost fully consolidated Ti-5Al-5Mo-5V-3Cr pre-forged material from powder with a controlled beta grain size, which is not possible by other methods.
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Julianto, Eko, and Sunaryo Sunaryo. "ANALISIS PENGARUH PUTARAN MESIN PADA EFISIENSI BAHAN BAKAR MESIN DIESEL 2DG-FTV." Jurnal Penelitian dan Pengabdian Kepada Masyarakat UNSIQ 7, no. 3 (September 30, 2020): 225–31. http://dx.doi.org/10.32699/ppkm.v7i3.1282.
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Penelitian ini bertujuan untuk mengetahui konsumsi bahan bakar dengan variasi putaran yang berbeda-beda. Pengujian dilakukan pada unit mobil Toyota Innova Diesel tahun 2016 dengan tipe engine 2DG-FTV. Penelitian ini menggunakan metode variasi putaran pada mesin dengan putaran 750 rpm, 1200 rpm, 1600 rpm, 2000 rpm, 2400 rpm, 2800 rpm, 3400 rpm, 4000 rpm dalam kondisi diam. Tekanan akhir kompresi adalah tekanan campuran udara-bahan bakar pada akhir langkah kompresi dan n1 adalah eksponen polytropik yaitu eksponen yang menunjukan sifat dan bentuk dari proses adiabatic. Temperatur Akhir Kompresi (Tc) adalah temperatur campuran bahan bakar sebelum pembakaran (pada akhir langkah kompresi), Efisiensi thermal adalah perbandingan antara energi yang berguna dengan energi yang masuk. Nilai H, C dan O dinyatakan dalam persentasi berat dalam setiap unsur yang terkandung dalam satu kilogram bahan bakar. Hasil pengujian didapat bahwa putaran 4000 rpm dihasilkan Vf 0,692 ml/menit, mf dihasilkan 0,0338 kg/jam, Sfc dihasilkan 0,0000381 kg/hp.h, Ne dihasilkan 889,132 Hp dan Torsi (T) dihasilkan 159,199 N.m. Waktu pengujian masing-masing variasi putaran 60 detik. Dari hasil percobaan laju konsumsi bahan bakar (mf) berbanding lurus dengan putaran mesin (rpm) dan konsumsi bahan bakar Spesifik (Sfc) berbanding terbalik dengan putaran mesin, maksudnya konsumsi bahan bakar semakin efisien pada saat putaran mesin semakin tinggi khususnya di rpm rendah dan sedang.
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Wibowo, Sandi, Suryanto Suryanto, and Duto Nugroho. "KARAKTERISTIK UPAYA DAN DAERAH PENANGKAPAN PUKAT CINCIN PELAGIS BESAR YANG BERPANGKALAN DI PPS BITUNG." Jurnal Penelitian Perikanan Indonesia 22, no. 1 (September 23, 2016): 51. http://dx.doi.org/10.15578/jppi.22.1.2016.51-60.
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<p>Pelabuhan Perikanan Samudra Bitung berperan penting dalam mendukung operasi armada perikanan pukat cincin pelagis besar yang ditujukan untuk memanfaatkan sumberdaya ikan tuna di WPPNRI 714, 715, 716 dan 717 yang mewakili perairan kepulauan, ZEEI dan laut lepas. Analisis deskriptif terhadap data logbook 2011-2013 perikanan pukat cincin pelagis besar ditujukan untuk mendapatkan karakteristik armada, sebaran daerah dan aktivitas penangkapan pukat cincin yang berpangkalan di PPS Bitung. Karakteristik upaya ditekankan pada rerata dimensi dan ukuran panjang kapal pukat cincin pelagis besar yang beroperasi memberikan informasi bahwa armada yang beroperasi pada 2013 berukuran rata-rata panjang 22,9 m (dengan kisaran 12,7 – 33,5) dengan ukuran bobot kapal 69,6 GT (18-200) serta kekuatan mesin sebesar 317,5 DK (80-1200). Operasional penangkapan menggambarkan kisaran jarak dan durasi antar tawur pada rumpon. Hasil analisis memberikan indikasi bahwa dari 106 unit kapal pukat cincin yang beroperasi 49% diantaranya aktif menangkapi 1 WPP, 41% di 2 WPP, dan 10% di 3 WPP, tidak ditemukan kapal yang beroperasi di empat WPP. Sebaran aktivitas penangkapan tertinggi pada 2013 ditemukan di WPP 715 sebesar 1828 tawur sedangkan terendah ditemukan di laut lepas sejumlah 9 tawur. Laju tangkap tertinggi pada 2013 (20,9 ton/tawur) terdapat di WPP 714 sedangkan hasil tangkapan per tawur terendah (6,11 ton/tawur) ditemukan di WPP 716. Musim penangkapan yang diwakili oleh frekuensi upaya tawur bulanan tidak menggambarkan adanya perbedaan yang nyata.</p><p> </p><em>Ocean fishing port of Bitung has an essential role provides fishing operation needs of tuna and skipjack purse seine fishery that operating their fleets in four Fisheries Management Areas (FMAs) 714, 715, 716 and 717 represent archipelagic, IZEE and high seas waters. Fisheries logbook and Vessel Monitoring System (VMS) data were collected during the port performance research program in 2014. Exploratory data analyses were applied to data of 2011 to 2013. The objective of this study is to describe the purse seine fleet characteristics, distribution of fishing grounds including estimate of catch rates. Integrating VMS data and logbook were explored to estimate range of distance and duration between fishing activities. The average length over all (LOA) of active vessels in 2013 was 22.9 m (12.7 – 33.5 m) with tonnage of 69.6 GT (18-200 GT) and engine power of 317.5 HP (80-1200 HP). Descriptive analysis indicates that 49% of 106 vessels operate only in one FMA, 41% in two FMAs and the last 10% operate in three FMAs, no fleet operate in four FMAs. The highest fishing activities in 2013 found in FMA 715 with 1828 hauls while the lowest are found on the high seas with 9 hauls. The highest catch per unit effort in 2013 was found on FMA 714 (20.9 tons/setting) while the lowest was found in FMA 716 (6.11 tons/setting). Fishing season is represented by frequency of gear setting indicated that there is no significantly seasonal difsference. </em>
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Al-Zaidi, H. K., M. J. Al-Bermani, and A. M. Taleb. "Reentry of Space Debris from Low Earth Orbit by Pulsed Nd:YAG Laser." Journal of Kufa-Physics 12, no. 02 (December 10, 2020): 39–51. http://dx.doi.org/10.31257/2018/jkp/2020/120204.
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This research studies the orbital dynamics of space debris in near earth orbit. The orbital dynamics of space debris is closely examined in near earth orbit whereby (apogee altitude ha=1200 km and perigee altitude hp=200 km). In addition, the lifetime of the space debris is calculated using the influence of the friction force exerted on the atmospheric particles with debris dimensions measuring between (1 and 10 cm). In this study, the Drag Thermospheric Models (DTM78 and DTM94) are used because of their dependence on solar and geomagnetic activities, and pulsed lasers are utilized to interact with Aluminum 2024 particles which are frequently employed in the structure of spacecraft and aerospace designs. A numerical analysis program (NaP1) was built to calculate the lifetime of space debris and its time of return to the atmosphere. It is then integrated with a second numerical analysis program (NaP2) developed using the Lax-Wendroff finite difference method to simulate the laser material interaction model. A high power Nd:YAG laser was applied to produce shock wave pressure in target. The results show that the maximum peak pressure occurs at 50 µm depth then slowly decays, the peak pressure increases with the increase of the laser intensity, and the optimum value of the momentum coupling coefficient (Cm) for the aluminum debris of size range (1and10 cm) is 6.5 dyn.s/j.
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Al-Zaidi, H. K., M. J. Al-Bermani, and A. M. Taleb. "Reentry of Space Debris from Low Earth Orbit by Pulsed Nd:YAG Laser." Journal of Kufa-Physics 12, no. 02 (December 10, 2020): 39–51. http://dx.doi.org/10.31257/2018/jkp/2020/120204.
Full textAbstract:
This research studies the orbital dynamics of space debris in near earth orbit. The orbital dynamics of space debris is closely examined in near earth orbit whereby (apogee altitude ha=1200 km and perigee altitude hp=200 km). In addition, the lifetime of the space debris is calculated using the influence of the friction force exerted on the atmospheric particles with debris dimensions measuring between (1 and 10 cm). In this study, the Drag Thermospheric Models (DTM78 and DTM94) are used because of their dependence on solar and geomagnetic activities, and pulsed lasers are utilized to interact with Aluminum 2024 particles which are frequently employed in the structure of spacecraft and aerospace designs. A numerical analysis program (NaP1) was built to calculate the lifetime of space debris and its time of return to the atmosphere. It is then integrated with a second numerical analysis program (NaP2) developed using the Lax-Wendroff finite difference method to simulate the laser material interaction model. A high power Nd:YAG laser was applied to produce shock wave pressure in target. The results show that the maximum peak pressure occurs at 50 µm depth then slowly decays, the peak pressure increases with the increase of the laser intensity, and the optimum value of the momentum coupling coefficient (Cm) for the aluminum debris of size range (1and10 cm) is 6.5 dyn.s/j.
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Espinoza, Evelyn Patricia Sanchez, Lauro Viera Perdigão Neto, Sania Alves dos Santos, Camila Risek, Maria Renata Gomes Franco, Roberta C. R. Martins, Gaspar C. O. Pereira, et al. "1210. Investigating a Staphylococcus aureus Outbreak in a Clinical Intensive Care Unit: What Is the Role of the Mobile Phones?" Open Forum Infectious Diseases 6, Supplement_2 (October 2019): S435. http://dx.doi.org/10.1093/ofid/ofz360.1073.
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Abstract Background Staphylococcus aureus (Sa) outbreaks are serious infections that if not controlled in time can be life-threating. The aim of this study was to describe the investigation and control of a Sa outbreak in an intensive care unit including analysis of MP. Methods During a microbiological research of MP conducted in December 2018 in a clinical intensive care unit (ICU) of a tertiary university hospital two patients had an MRSA infection. Since this unit had not reported MRSA infections during the last year it was recognized as an outbreak. The CDC criteria was applied to define MRSA colonization and infection. Hand hygiene (HH) adhesion in this unit was 47%,it has 9 beds and 30 Healthcare professionals (HP). Nasal Swab (NS) of all the HPs and of the patients in the same unit as well. HP’s MP were also analyzed. The samples were subjected to MALDI-TOF (Biomerieux), phenotypical tests, PCR for detection of gene coA and mecA, pulsed-field gel electrophoresis (PFGE), and whole-genome sequence to access resistance, virulence profile and sequence type. Feedback of microbiology results, reinforcement of hand hygiene and MP cleaning was discussed with the unit staff. Results A total of 34 samples were collected, 25 were Sa, 13 NS of all HPs and patients, 7 from the MPs and 3 from HPs hands. During the time of the outbreak 5 patients were in the unit. Patients with infection by MRSA (n = 2), had Methicillin-susceptible Sa in their NSs. Another patient that from the same unit had a MRSA in the NS that when submitted to PFGE was seen to be closely related with the MRSA that originated the outbreak. The patients isolates were assigned to different STs and they had more virulent and resistance genes in comparison with two samples of MPs. The Sa recovered from the MPs belonged to the same ST, same resistance gene and same virulent genes. Figure 1, Table1. Since the feedback to the unit no cases of MRSA have been reported in the last 4 months. Conclusion The outbreak was controlled using simply measures (feedback, reinforcement of HH and MP cleaning). The ST398 from the MP has already been described in outbreaks in literature. It seems that MP can be a reservoir for Sa There was more than one Sa lineage in the ICU. Our findings highlighted the need of rethinking the MP cleaning policy in our hospital. Disclosures All authors: No reported disclosures.
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ASIF M., MOHAMMED, KULKARNI ANUP SHRIKRISHNA, and P. SATHIYA. "METALLURGICAL AND CORROSION CHARACTERIZATION OF POST WELD HEAT TREATED DUPLEX STAINLESS STEEL (UNS S31803) JOINTS BY FRICTION WELDING PROCESS." Surface Review and Letters 23, no. 03 (May 3, 2016): 1650013. http://dx.doi.org/10.1142/s0218625x1650013x.
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The present study focuses on the metallurgical and corrosion characterization of post weld heat treated duplex stainless steel joints. After friction welding, it was confirmed that there is an increase in ferrite content at weld interface due to dynamic recrystallization. This caused the weldments prone to pitting corrosion attack. Hence the post weld heat treatments were performed at three temperatures 1080[Formula: see text]C, 1150[Formula: see text]C and 1200[Formula: see text]C with 15[Formula: see text]min of aging time. This was followed by water and oil quenching. The volume fraction of ferrite to austenite ratio was balanced and highest pit nucleation resistance were achieved after PWHT at 1080[Formula: see text]C followed by water quench and at 1150[Formula: see text]C followed by oil quench. This had happened exactly at parameter set containing heating pressure (HP):40 heating time (HT):4 upsetting pressure (UP):80 upsetting time (UP):2 (experiment no. 5). Dual phase presence and absence of precipitates were conformed through TEM which follow Kurdjumov–Sachs relationship. PREN of ferrite was decreasing with increase in temperature and that of austenite increased. The equilibrium temperature for water quenching was around 1100[Formula: see text]C and that for oil quenching was around 1140[Formula: see text]C. The pit depths were found to be in the range of 100[Formula: see text]nm and width of 1.5–2[Formula: see text][Formula: see text]m.
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MPOSKOS, E. "Petrology of the ultra-high pressure metamorphic Kimi complex in Rhodope (NE Greece). A new insight into the Alpine geodynamic evolution of Rhodope." Bulletin of the Geological Society of Greece 34, no. 6 (January 1, 2002): 2169. http://dx.doi.org/10.12681/bgsg.16860.
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Structural, penological and geochronological work has revealed that the Rhodope metamorphic province is a synmetamorphic nappe-system of Alpine age. The Kimi complex representing the uppermost entity underwent UHP metamorphism in Lower Cretaceous (>119 Ma). Diamond inclusions in garnet porphyroblasts, exsolutions of quartz rods and rutile needles in garnet from Grt-Ky-Bt-gneisses constrain pressures >4 GPa (probably -7 GPa) and temperatures > 1000 °C, indicating subduction of continental crust into the asthenospheric mantle. The garnet-spinel peridotite of the Kimi area represents a segment of upwelling asthenosphere reequilibrated into the lithospheric mantle wedge at -2.5 GPa and 1235 °C. The spinel-garnet clinopyroxenites, associated with the peridotite, represent HP mantle cumulates crystallized from a melt at similar P-T conditions (i.e. P-2.4 GPa, T~1200°C). Decompression and cooling took place in the mantle wedge within the Cr-Spinel peridotite field up to -1.8 GPa and 900 °C. Subsequent isobaric cooling crossed the stability field of garnet peridotite. At this stage, the peridotite was tectonically emplaced into the educted underlying continental crust. Three stages of exhumation of the crustal assemblage occurred in the Kimi Complex. The first stage, from the maximum depth of -200- 220 Km to -60 Km (P-1.6 GPa, T-800 °C), is characterized by slow cooling rates, indicating rapid exhumation. The second stage, from -60 Km to -38 Km (P-1.05 GPa, T~640°C), is indicated by cooling at slow rates and is characterized by hydration and annealing reequilibration/recrystallization processes. The third stage of exhumation started between 73 and 65 Ma and is characterized by rapid uplift, continuous influx of water, intrusion of muscovite pegmatites at -20 Km depth, and finally by rapid cooling at shallow levels. The Kimi Complex reached the surface before 48-42 Ma.
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Gilarranz, J. L., L. W. Traub, and O. K. Rediniotis. "A New Class of Synthetic Jet Actuators—Part I: Design, Fabrication and Bench Top Characterization." Journal of Fluids Engineering 127, no. 2 (March 1, 2005): 367–76. http://dx.doi.org/10.1115/1.1839931.
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Although the potential of synthetic jets as flow separation control actuators has been demonstrated in the existing literature, there is a large gap between the synthetic jet actuators (SJA) used in laboratory demonstrations and the SJAs needed in realistic, full-scale applications, in terms of compactness, weight, efficiency, control authority and power density. In most cases, the SJAs used in demonstrations are either too large or too weak for realistic applications. In this work, we present the development of a new class of high-power synthetic jet actuators for realistic flow control applications. The operating principle of the actuator is the same as that of crankshaft driven piston engines, which makes a significant part of the technology necessary for the actuator development available off-the-shelf. The design of the actuator is modular and scalable. Several “building block” units can be stacked in series to create the actuator of the desired size. Moreover, active exit slot reconfiguration, in the form of variable exit slot width, decouples the actuator frequency from the actuator jet momentum coefficient and allows the user to set the two independently (within limits). Part I of this paper presents the design, fabrication and bench top characterization of the actuator. Several versions of the actuator were designed, built and tested, leading up to the development of a six-piston compact actuator that has a maximum power consumption of 1200 W (1.6 hp) and can produce (for the tested conditions) peak exit velocities as high as 124 m/s. In Part II, the actuator was housed in the interior of a NACA0015 profiled wing with a chord of 0.375 m (14.75 inches). The assembly’s performance in controlling flow separation was studied in the wind tunnel.
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Hemeda, O. M., A. Tawfik, D. M. Hemeda, and A. M. Elsheekh. "Preparation and electrical properties of Ni–Cu–Zn system doped with the magnesium oxide." International Journal of Modern Physics B 28, no. 23 (July 13, 2014): 1450157. http://dx.doi.org/10.1142/s0217979214501574.
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A sery of ferrite samples, Ni 0.1 Cu 0.2 Mg x Zn 0.7-x Fe 2 O 4, (x = 0.00, 0.15, 0.25, 0.35, 0.45, 0.55 and 0.70) have been prepared by the standard ceramic techniques, sintered at 1200°C for 2 h, and their crystalline structures were investigated by using X-ray diffraction, which confirmed the formation of Ni 0.1 Cu 0.2 Mg x Zn 0.7-x Fe 2 O 4 phase. The presence of Mg content increases the crystallinity of the given ferrite which is considered as catalyst for the accomplishment of the solid state reaction. The lattice parameter and crystallite size were calculated from XRD. The cationic distribution was estimated from the theoretical values of lattice parameters. The IR spectra analysis has been studied. The dielectric constant for the ferrite system Ni – Cu – Zn gradually increases with temperature up to nearly Curie temperature and then increase sharply beyond the Tc. The Curie temperature obtained from the [Formula: see text] versus T is in agreement with the Curie temperature obtained from other measurements. Dielectric loss tangent ( tan δ) has the same behavior as dielectric constant [Formula: see text]. A minimum value of dielectric loss tangent ( tan δ) for the system " Ni – Cu – Zn " was observed at x = 0.45. Magnetic permeability has been studied. The dependence of initial permeability on temperature exhibit a peak which is called Hopkinson peak (HP) in the vicinity of Curie temperature and confirmed the phase purity of ferrite sample. The increasing of porosity and decreasing of grain size play an important role in decreasing μi. It is clear that the value of Tc is found to increase by increasing the concentration of diamagnetic substitution Mg for " Ni – Cu – Zn " system.
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Basarab, J. A., M. A. Price, J. L. Aalhus, E. K. Okine, W. M. Snelling, and K. L. Lyle. "Residual feed intake and body composition in young growing cattle." Canadian Journal of Animal Science 83, no. 2 (June 1, 2003): 189–204. http://dx.doi.org/10.4141/a02-065.
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Crossbred steers (n = 176), 7–8 mo of age and from the five BeefBooster strains (M1, M2, M3, M4 and TX), were used to determine the relationships between residual feed intake (RFI) and growth rate, body composition and heat production (HP), and to quantify differences in RFI independent of differences in body composition. Animals with different RFI levels were also characterized for growth, carcass and body compositional traits. Steers from each genetic strain were selected at random and serially slaughtered on 5 pre-selected days of the finishing period. Steers grew at 1.52 (SD = 0.22) kg d-1 and had dry matter intake (DMI) of 8.5 (SD = 1.0) kg d-1 during the last 71 to 183 d before slaughter. Metabolic mid-point weight, average daily gain (ADG), gain in empty body fat and gain in empty body water accounted for 67.9, 8.6, 3.9 and 1.1%, respectively, of the variation in actual feed intake. Similarly, metabolic mid-point weight (68.5%), ADG (8.2%), gain in ultrasound backfat thickness (1.8%), gain in ultrasound marbling score (1.1%) and year (1.3%) accounted for 80.9% of the variation in actual feed intake. Residual feed intake adjusted for differences in estimated composition of gain (estimated gain in empty body fat and water; RFIII) ranged from -2.06 kg d-1 to +1.61 kg d-1 (SD = 0.60 kg d-1). Residual feed intake adjusted for live animal measures of body composition (gain in ultrasound backfat thickness and marbling score; RFIIII) ranged from -2.11 kg d-1 to +1.88 kg d-1 (SD = 0.62 kg d-1). Low RFIIII animals (efficient) had 6.0% lower metabolizable energy intake (MEI), retained 9.3% less energy and had 4.5% lower HP than medium RFIIII animals (P < 0.01). Low RFIIII animals also had 10.2% lower MEI, retained 12.0% less energy and produced 9.3% less heat than high RFIIII animals (P < 0.01). Liver (P <0.01), small and large intestine (P = 0.09) and stomach and intestine (P < 0.01) weights were less in low and medium RFIIII steers compared to high RFIIII steers. There was a trend for low RFIIII steers to have less dissectible carcass fat (P = 0.08), intermuscular fat (P = 0.06), body cavity fat in the butt and loin (P = 0.01), faster accretion rate of empty body water (P = 0.04) and a slower accretion rate of empty body fat (P < 0.01) than medium and high RFIIII steers. A portion of the greater MEI by high RFIIII steer was accounted for by differences in the chemical composition of gain. However, a greater proportion was due to a disproportionate increase in the energy required for maintenance and heat increment of feeding in high RFIIII steers. An attempt should be made to adjust RFI for changes in the chemical composition of gain, possibly by the inclusion of ultrasound backfat thickness and marbling score into the equation for determining RFI. Key words: Cattle, feed efficiency, residual feed intake, remote sensing, GrowSafe System
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Fothergill, Amy, Samantha Huey, Jere Haas, Shobha Udipi, Padmini Ghugre, Varsha Thakker, Harsha Chopra, Ramesh Potdar, Saurabh Mehta, and Julia Finkelstein. "Anemia and Micronutrient Deficiencies in Young Children in Urban Slums of Mumbai, India." Current Developments in Nutrition 4, Supplement_2 (May 29, 2020): 828. http://dx.doi.org/10.1093/cdn/nzaa053_033.
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Abstract Objectives To examine the burden of anemia and micronutrient deficiencies among young children living in urban slums of Mumbai, India. Methods Participants were children 10–18 months of age (n = 278) residing in urban slums in Mumbai who were screened as part of a randomized feeding trial of biofortified pearl millet. Venous blood was collected by a pediatric phlebotomist and hemoglobin (Hb) concentrations were assessed via Coulter counter. Samples were processed and stored <−80°C until laboratory analyses. Serum ferritin (SF), vitamin B12, and erythrocyte (RBC) folate concentrations were analyzed via chemiluminescence. C-reactive protein (CRP) was analyzed by nephelometry, α-1 acid glycoprotein (AGP) was analyzed by spectrophotometry, and serum retinol was evaluated via HP-LC. Serum ferritin and serum retinol levels were adjusted for inflammation using methods proposed by Thurman. Anemia and severe anemia were defined as Hb < 11.0 g/dL and Hb < 7.0 g/dL. Iron deficiency (ID) was defined as SF < 12.0 µg/L, iron insufficiency was defined as SF < 20.0 µg/L, and inflammation was defined as CRP > 5.0 mg/L. Iron deficiency anemia was defined as Hb < 11.0 g/dL and SF < 12.0 µg/L. Vitamin A deficiency was defined as serum retinol <20.0 µg/L. Vitamin B12 deficiency and vitamin B12 insufficiency were defined as <148.0 pmol/L and <221.0 pmol/L; folate deficiency was defined as RBC folate <340 nmol/L. Linear and binomial regression models were used to examine associations of micronutrient biomarkers with Hb levels and risk of anemia. Results A total of 75.5% of children were anemic and 2.9% had severe anemia. The prevalence of iron deficiency was 61.4% (69.5% after Thurman adjustment), 57.4% of children had IDA, and 9.7% had CRP > 5.0 mg/L. The prevalence of vitamin B12 deficiency was 17.0%, 41.8% of children had vitamin B12 insufficiency, and 19.9% had folate deficiency. Among anemic children, 84.5% had ≥1 micronutrient deficiency and 22.7% had ≥ 2 micronutrient deficiencies. Iron deficiency (RR: 2.15; 95% CI: 1.55, 2.99; P < 0.001), and vitamin B12 deficiency (RR: 1.32; 95% CI: 1.09, 1.60; P < 0.01) were associated with significantly increased risk of anemia. Conclusions Findings indicate that the burden of anemia, iron deficiency, and vitamin B12 insufficiency were high in young children in Mumbai, India. Funding Sources Harvest Plus; AF was supported by the National Institutes of Health.
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Clingan, Philip R., Stephen P. Ackland, Marie Ranson, Daniel Brungs, Morteza Aghmesheh, Ali Tafreshi, Madhu Bala Garg, et al. "Deflexifol (a novel formulation of 5FU): Phase 1 dose escalation study of infusional and bolus schedules after failure of standard treatment." Journal of Clinical Oncology 35, no. 15_suppl (May 20, 2017): 2529. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.2529.
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2529 Background: 5-Fluorouracil (5FU) is administered in combination with leucovorin (LV) to enhance clinical activity. However, simultaneous administration is not feasible as 5FU and LV are chemically incompatible, so the maximum possible interaction for benefit is not achieved Deflexifol, an all in one formulation of 5FU/LV with cyclodextrin (HP-β-CD 100mg/ml, 5-FU 15mg/ml & LV 1mg/ml) at physiological pH, was developed to improve efficacy and tolerance. Methods: A phase I dose-escalation trial to assess the safety, tolerability, MTD and DLT of Deflexifol given in two schedules has been completed. Secondary objectives included the pharmacokinetic (PK) profile and efficacy outcomes. Cohorts of patients with advanced malignancy after failure of standard treatment received Deflexifol as 46-h infusion Q2W or bolus weekly x6 in a standard 3+3 phase I design with no intra-patient dose escalation from dose level 1: 375mg/m² bolus or 1200mg/m² infusional up to dose level 5: 575mg/m² bolus or 3600mg/m² infusional. PK sampling of 5FU and dihydroFU was conducted on all patients to assess PK variability and adequacy of dosing. Results: 40 patients (21 infusional, 19 bolus) with breast (7), colorectal (24), other GI (6) & NSCLC (3) received a total 293 courses of treatment. No > grade 1 toxicity was noted at 375-475 mg/m2 bolus, or at 1200-2400 mg/m2 infusion. The DLT in bolus schedule was grade 3 diarrhea and myelosuppression at 575 mg/m2, with no DLT in the infusion schedule at the maximum dose 3600 mg/m2. The MTD have been established for both treatment arms: bolus 525mg/m²; 46-h infusion 3,600mg/m², with no grade IV toxicity observed. Other grade 3 toxicities were nausea, vomiting, and raised liver function tests. 5FU PK in this mixture is similar to 5FU alone. Encouraging efficacy results were seen with partial response in 1 patient and stable disease in 23 patients. Median PFS was (12.3 wks) and OS was (24.8 wks). Conclusions: Deflexifol has little toxicity and is effective in bolus and infusion schedules at doses equal to or greater than those feasible with 5FU and LV infused separately. A first-line phase II study in combination with oxaliplatin is planned. Clinical trial information: 044867.
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Ackland, Stephen P., Madhu Bala Garg, Marie Ranson, Rebecca Jokela, Daniel Brungs, Morteza Aghmesheh, Ali Tafreshi, et al. "Deflexifol (a novel formulation of 5FU): Pharmacokinetics in a phase 1 trial in comparison to 5FU." Journal of Clinical Oncology 35, no. 15_suppl (May 20, 2017): 2530. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.2530.
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2530 Background: Simultaneous administration of 5-fluorouracil (5FU) and leucovorin (LV) is generally not feasible as 5FU and LV are chemically incompatible (CaPO4 crystals), so the maximum possible interaction for benefit is not achieved. Deflexifol, an all in one formulation of 5FU/LV with cyclodextrin (HP-β-CD 100mg/ml, 5-FU 15mg/ml & LV 1mg/ml) at pH 7, was developed to overcome this problem. Methods: Limited sampling PK was done with dose 1 and 6 in a standard 3+3 phase I trial of Deflexifol given in two schedules (46-h infusion Q2W or bolus weekly x6) with no intrapatient dose escalation, at doses shown in Table. Sample times were infusion: 0, 2, 46h; bolus: 0, 0.2, 0.4, 1, 24h. 5FU and dihydroFU were measured as per Ackland et al, Anal Biochem 1997. 5FU AUC, clearance (CLR) and t1/2 were estimated for each patient to assess PK variability and adequacy of dosing compared to previous reports. Results: 40 patients were treated (21 infusion, 19 bolus, median age 67, 19 M, 21 F). The MTD(bolus) was 575 mg/m2, with no DLT in infusion schedule to 3600 mg/m2. PK showed substantial inter-patient variability – CLR(bolus) 21-900 L/h, t1/2 0.11-0.52 h, with intra-patient dose 6 CLR = 54-117% of dose 1, and a trend to increased AUC (mg/L.h) with dose (Table). Infusion CLR and AUC estimates were highly variable (CLR range 2-1200), with many cases with insufficient data. Compared to historical data with 5FU alone, AUC was likely subtherapeutic until 475mg/m2 bolus and for many patients with infusion <3000mg/m2. Conclusions: 5FU PK with Deflexifol is similar to 5FU alone. No evidence of saturation of kinetics over this dose range was seen, or induction of metabolism with repeated dosing. In each schedule AUC data supports the clinical impression of reduced toxicity at the same dose of 5FU. Accurate estimation of infusion PK requires more than 2 timepoints. PK in a phase II study is planned. Clinical trial information: 044867. [Table: see text]
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Bernaudin, Francoise, Suzanne Verlhac, Regis Peffault Delatour, Jean-Hugues Dalle, Eleonore Petras, Valentine Brousse, Isabelle Thuret, et al. "Cerebral Arterial Velocities in SCA-Children with Abnormal Doppler Are Reduced and Normalized More Frequently after Transplantation Than after Transfusion Program (French National Trial “Drepagreffe” AP-HP N°: NCT 01340404)." Blood 124, no. 21 (December 6, 2014): 561. http://dx.doi.org/10.1182/blood.v124.21.561.561.
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Abstract Background : Evidence-based practices have shown that transfusion program (TP) is beneficial to SCA-patients with abnormally high velocities by Doppler; however, TP cannot be stopped safely, except following HSCT. No prospective trial has to date compared the extent of cerebral vasculopathy following TP or HSCT. The premise of the French National Trial “Drepagreffe” is that cerebral velocities will be reduced to a greater extent after HSCT than under TP. Patients and Methods : We present here preliminary results from this prospective trial with 2 arms (TP/HSCT), defined by the random-availability of a genoidentical donor. Inclusion criteria were SCA (SS/Sb0) children younger than 15 years with a history of abnormal cerebral arterial velocities (TAMMX ≥ 200 cm/sec), placed on long-term transfusion programs, with at least one non-SCA sibling and parents accepting HLA-typing and HSCT if a genoidentical donor was available. Transplanted patients received as conditioning regimen Busilvex-CY 200 mg/kg and 20 mg/kg rabbit Thymoglobulin with CSA and short MTX or MMF for GVHD prophylaxis. In the TP arm, HbS% was maintained at < 30% with Hb 9-11g/dL. At enrollment and 12 months post-enrollment, blood screening, Doppler, cerebral MRI/MRA were performed along with cognitive performance testing, the latter done in parallel in the control sibling. Primary endpoint was the significantly greater reduction of velocities in the HSCT than in the TP arm. Among the various secondary endpoints, Doppler normalization defined by velocities < 170 cm/s in all arteries was to occur more often after HSCT than on TP. Results: SCA-children (n=67; 36F-31M) from 10 French SCA-centers were enrolled between 12/2010 and 6/2013 at the mean (SD) age of 7.6 (3.1) years. History of stroke was present in 6 patients (4 in HSCT and 2 in TP) and 1 TIA in HSCT arm. At TP initiation, velocities≥200/cm/sec were found in middle (n=50), anterior (n=11) and internal carotid arteries (n=30) as abnormal velocities were observed in more than one artery in several patients. Mean (SD) maximum velocities were 219 (26) cm/s (range: 200-333). At enrollment all patients were on TP and paired analysis showed that mean(SD) maximum velocities had significantly decreased (p<0.001) under TP:169 (46) cm/s vs 219 (26) cm/s). Following HLA-typing, 35 without genoidentical donor were included in the transfusion arm and 32 with genoidentical donor were transplanted in 6 HSCT-centers. Mean (SD) maximum velocities were not significantly different in both arms at enrollment: 167 (41) in TP vs 170 (51) cm/s in HSCT. During the 12 months follow-up, no stroke was observed but one patient in the TP arm experienced a hyperammonemic reversible coma, without MRI/MRA alteration requiring transfer to intensive care. In the HSCT arm, all patients successfully engrafted, one grade II and two grade III acute GVHD, and no chronic GVHD were observed. Two patients required transfer to intensive care for seizures and pneumonia. Other complications were seizures (n=2), CMV (n=9) or EBV replications (n=1), hemorrhagic cystitis (n=3), aspergillosis (n=1), prolonged but reversible thrombopenia (n=2), transitory hemolytic anemia (n=1). At 12 months, data, available in 63/67 patients, showed that all patients were alive, mean (SD) Hb and HbS% in TP arm were 9.1 (0.9) and 27.5% (11.9), respectively, whereas in the HSCT arm, mean (SD) Hb and % donor chimerism were 12.0 (1.0) g/dL and 86.5% (12.2) respectively (range:60-100%). All transplanted patients had the same Hb electrophoresis than their donor. Mean (SD) maximum velocities were significantly lower post-HSCT (n=31) than under TP (n=32):128 (34) vs 174 (36) cm/s, respectively; (p<0.001), and were decreased more significantly following HSCT than on TP: mean(SD)Δ: -44 (24) vs +6 (3), respectively. The percentage of patients with normal velocities was significantly higher post-HSCT (27/31) than in the TP arm (16/32) (p=0.003). Conclusions: This prospective national trial comparing TP vs. HSCT in SCA-patients with a history of abnormal velocities shows for the first time that HSCT repeatedly and significantly results in a greater decrease in velocities than TP, and has very little toxicity. These preliminary results are encouraging and suggest that suppression of host SCA-erythropoiesis by HSCT is the treatment of choice for SCA-children with abnormal-TCD and genoidentical donor. Figure 1 Figure 1. Figure 2 Figure 2. Disclosures Bernaudin: Novartis: Research Funding.
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Mesto, Ernesto, Salvatore Laurita, Maria Lacalamita, Rosa Sinisi, Giovanna Rizzo, Emanuela Schingaro, and Giovanni Mongelli. "Crystal Chemistry and Thermal Behavior of Fe-Carpholite from the Pollino Massif, Southern Italy." American Mineralogist 106, no. 1 (January 1, 2021): 123–34. http://dx.doi.org/10.2138/am-2020-7385.
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Abstract The crystal chemistry and thermal behavior of Fe-carpholite from the Pollino Massif have been investigated by a multi-method approach. A combination of optical microscopy, scanning electron microscopy, mRaman spectroscopy, thermal analysis, room-temperature single-crystal X-ray diffraction, and high-temperature X-ray powder diffraction was employed. Field and micromorphological observations showed that the studied carpholite occurs in veins embedded in fine-grained matapelites and coexist with quartz, calcite, chlorite, and phengite. In particular, the tiny carpholite crystals are closely associated with quartz, suggesting simultaneous formation. Structure refinements from single-crystal X-ray diffraction confirm that carpholite crystallizes in the Ccce space group. Anisotropic refinements converged at 2.3 ≤ R (%) ≤ 2.6 and yielded unit-cell parameters a ~13.77 Å, b ~20.16 Å, c ~5.11 Å, and V ~1419 Å3. An XFe [i.e., the molar fraction Fe2+/(Mg+Fe2++Mn)] of ~0.6 was derived from the refined occupancy at the M1 site and is correlated to structural expansion mainly along the b and a axes and to geometrical distortions of the M1, M2, and M3 octahedra. mRaman spectrum of unoriented Fe-carpholite crystals exhibits several bands in the 200–1200 cm–1 region, a strong peak at 3630 cm–1 and a weak peak at 3593 cm–1, the latter two of which account for the presence of two independent OH groups, as also revealed by the X-ray structure refinement. The TG curve indicates a total mass loss of 15.6% in the temperature range 30–1000 °C, and the DTA curve shows a broad endothermic band at ~400 °C, extending up to ~650 °C, and weak exothermic peaks at ~700 and 750 °C. The latter may be ascribed to the breakdown of the Fe-carpholite structure and crystallization of new phases. The in situ high-temperature X-ray powder diffraction from 30 to 1105 °C revealed no significant changes in XRD patterns from 30 to 355 °C but reflection splittings from 380 °C due to a Fe-oxidation/deprotonation process. The carpholite and deprotonated carpholite phases coexist in the temperature range 380–580 °C, whereas only the deprotonated phase is observed up to 630 °C. Above this temperature, the carpholite structure collapses and the characteristic peaks of spinel and quartz phases are observed. At 1105 °C, spinel, mullite, garnet, cristobalite, and tridymite can be clearly identified. Our results provide insight into the thermal stability of Fe-carpholites and may help understand the thermal evolution of HP/LT metasediments.