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Journal articles on the topic 'HP Beta-Cyclodextrin'

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Published: 5 June 2025

Last updated: 1 August 2025

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1

Liu, Hui, Jinhua Luo, Ping Yang, Xiulan Yang, Jun Yan, and Qian Yao. "Stability, Antioxidant Activity and Intestinal Permeation of Oleuropein Inclusion Complexes with Beta-Cyclodextrin and Hydroxypropyl-Beta-Cyclodextrin." Molecules 27, no. 16 (2022): 5077. http://dx.doi.org/10.3390/molecules27165077.

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Compared to beta-cyclodextrins (beta-CD), hydroxypropyl-beta-cyclodextrins (HP-beta-CD) are a more popular material used to prepare inclusion complexes due to their superior solubility and intestinal absorption. In this study, oleuropein (OL) inclusion complexes with beta-CD (beta-CD:OL) and HP-beta-CD (HP-beta-CD:OL) were prepared and the formation of inclusion complexes was validated by IR, PXRD, and DSC. A phase solubility test showed that the lgK (25 °C) and binding energy of beta-CD:OL and HP-beta-CD:OL was 2.32 versus 1.98, and −6.1 versus −24.66 KJ/mol, respectively. Beta-CD:OL exhibite

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2

Abhijit, Banik, та Dutta Saikia Monali. "Triflumizole encapsulation by 2-hydroxypropyl and sulphated derivatives of β-cyclodextrin". Journal of Indian Chemical Society Vol. 91, May 2014 (2014): 865–70. https://doi.org/10.5281/zenodo.5720090.

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Department of Chemistry, Arya Vidyapeeth College, Guwahati-781 016, Assam, India <em>E-mail</em> : monalisaikia@hotmail.com Fax : 91-361-244065 <em>Manuscript received online 07 March 2013, revised 27 June 2013, accepted 28 June 2013</em> Spectroscopic studies were done on the inclusion of triflumizole (TF) into the cavities of two derivatives of β-cyclodextrin namely hydroxypropyl-β-cyclodextrin (HP-β-CD) and sulphated-β-cyclodextrin (S-β-CD). The affinity of TF for the cavities of cyclodextrin derivatives was found to be dependent on the interaction forces responsibl

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3

Wang, Runmiao, Hui Zhou, Shirley W. I. Siu, Yong Gan, Yitao Wang, and Defang Ouyang. "Comparison of Three Molecular Simulation Approaches for Cyclodextrin-Ibuprofen Complexation." Journal of Nanomaterials 2015 (2015): 1–8. http://dx.doi.org/10.1155/2015/193049.

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Cyclodextrins are widely used for the solubilisation of poorly soluble drugs in the formulations. However, current cyclodextrin formulation development strongly depends on trial-and-error in the laboratory, which is time-consuming and high cost. The aim of this research was to compare three modeling approaches (Docking, molecular dynamics (MD), and quantum mechanics (QM)) for cyclodextrin/drug complexation. Ibuprofen was used as a model drug. Binding free energy from three simulation methods was calculated as an important parameter to compare with the experimental results. Docking results from

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4

Lv, Junli, Jiali Zou, Jianjiao Niu, and Guoze Wang. "Evaluation of orally disintegrating films containing ferulic acid inclusion complexes: Physical characteristics and release kinetics." Emirates Journal of Food and Agriculture 37 (June 30, 2025): 1–10. https://doi.org/10.3897/ejfa.2025.152376.

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Orally disintegrating films (ODFs) has gained significant attention as a nutrient delivery platform due to its ease of intake. But studies on delivering ferulic acid (FA) through ODFs are still scarce. The objective of this study was to assess the physical characteristics of ODFs containing FA/&beta;-cyclodextrin (0.5:1) (FA/&beta;-CD (0.5:1)) and FA/hydroxypropyl-&beta;-cyclodextrin (0.5:1) (FA/HP-&beta;-CD (0.5:1)) complexes, as well as analyze the release kinetics of FA in both ODFs. Confirmation of the FA/&beta;-CD (0.5:1) and FA/HP-&beta;-CD (0.5:1) inclusion compl

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Székely-Szentmiklósi, Blanka, and B. Tőkés. "Study of Cyclodextrin/Fluoroquinolone Inclusion Complexes by Capillary Electrophoresis." Acta Medica Marisiensis 59, no. 2 (2013): 107–10. http://dx.doi.org/10.2478/amma-2013-0026.

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AbstractIntroduction: In the present work we evaluated the complexation role of cyclodextrins toward fluoroquinolones in an attempt to assess their potential as new formulation additives for more efficient fluoroquinolone delivery and as selectors in capillary electrophoresis.Material and method: Guest-host interactions of two second generation quinolones, ciprofloxacin and norfloxacin with four cyclodextrins, beta-cyclodextrin (β-CD), gamma-cyclodextrin (γ-CD) and two beta-cyclodextrin derivatives, 2-hydroxypropyl beta-cyclodextrin (HP-β-CD) and randomly methylated beta-cyclodextrin (RAMEB),

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6

Kuzmanović Nedeljković, Snežana, Milica Radan, Dubravka Bigović, and Katarina Šavikin. "Cyclodextrin-aided green extraction from Fagopyrum esculentum Moench – an effective strategy for the sustainable recovery of polyphenols." Lekovite sirovine 44, no. 1 (2024): 1–9. https://doi.org/10.61652/leksir2444012k.

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&lt;p&gt;As a rich source of polyphenolic compounds, &lt;em&gt;Fagopyrum esculentum &lt;/em&gt;Moench herb, is a valuable subject for a numerous industries, such as pharmaceutical, chemical, food, or cosmetic. Given the biological potential that is closely related to the polyphenolic content, this study aimed to develop ecologically suitable cyclodextrin-aided extraction from the aerial parts of &lt;em&gt;F. esculentum&lt;/em&gt;. To maximize the polyphenolic content, highly-reliable mathematical and statistical method &amp;ndash; response surface me

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Pal, Kaushik, Falguni Chandra, Suman Mallick та Apurba L. Koner. "pH dependent supramolecular recognition of dapoxyl sodium sulfonate with 2-hydroxypropyl β-cyclodextrin: an application towards food-additive formulation". New Journal of Chemistry 40, № 7 (2016): 6093–100. http://dx.doi.org/10.1039/c5nj03415a.

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8

Ozon, Emma Adriana, Marian Novac, Daniela Gheorghe та ін. "Formation and Physico-Chemical Evaluation of Nifedipine-hydroxypropyl-β-cyclodextrin and Nifedipine-methyl-β-cyclodextrin: The Development of Orodispersible Tablets". Pharmaceuticals 15, № 8 (2022): 993. http://dx.doi.org/10.3390/ph15080993.

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The novelty in this study is the development of new orodispersible tablets containing nifedipine (NIF) as the active ingredient. Initially, the formation of inclusion complexes between nifedipine and two derivatives of beta-cyclodextrin, namely, hydroxypropyl-β-cyclodextrin (HP-β-CD) and methyl-β-cyclodextrin (Me-β-CD), was established. Inclusion complexes of nifedipine were prepared by different procedures: kneading, coprecipitation and lyophilization methods, using a 1:1 molar ratio among the drug and cyclodextrin compounds. A physical mixture was also developed for comparison, with the same

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9

Paczkowska-Walendowska, Magdalena, Jakub Dvorák, Natalia Rosiak, et al. "Buccal Resveratrol Delivery System as a Potential New Concept for the Periodontitis Treatment." Pharmaceutics 13 (March 20, 2021): 417. https://doi.org/10.3390/pharmaceutics13030417.

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Abstract: The health benefits of resveratrol have been proven to inhibit the development of numerous diseases. A frequent limitation in its use is a low bioavailability stemming from a poor solubility and fast enterohepatic metabolism. Thus, the aim of the research was to investigate the possibility to formulate mucoadhesive cyclodextrin- and xanthan gum-based buccal tablets in order to increase the solubility of resveratrol and to eliminate bypass enterohepatic metabolism. Systems of resveratrol with alpha-cyclodextrin (alpha-CD), beta-cyclodextrin (beta-CD), gamma-cyclodextrin (gamma-CD) and

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10

Wu, Hsien-Tsung, Yao-Hsiang Chuang, Han-Cyuan Lin, and Liang-Jung Chien. "Characterization and Aerosolization Performance of HydroxyPropyl-Beta-Cyclodextrin Particles Produced Using Supercritical Assisted Atomization." Polymers 13, no. 14 (2021): 2260. http://dx.doi.org/10.3390/polym13142260.

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In this study, hydroxypropyl-beta-cyclodextrin (HP-β-CD) particles were produced using supercritical assisted atomization (SAA) with carbon dioxide as the spraying medium or co-solute and aqueous ethanol solution as the solvent. The effects of several key factors on the morphology and size of the HP-β-CD particles were investigated. These factors included the solvent effect, temperatures of the precipitator and saturator, concentration of the HP-β-CD solution, and flow rate ratio of carbon dioxide to the HP-β-CD solution. The conducive conditions for producing fine spherical particles were 54.

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11

Chang, Chaokang, Meng Song, Mingxing Ma, Jihong Song, Fengyi Cao, and Qi Qin. "Preparation, Characterization and Molecular Dynamics Simulation of Rutin–Cyclodextrin Inclusion Complexes." Molecules 28, no. 3 (2023): 955. http://dx.doi.org/10.3390/molecules28030955.

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Rutin is a natural flavonoid that carries out a variety of biological activities, but its application in medicine and food is limited by its water solubility. One of the classical methods used to enhance drug solubility is encapsulation with cyclodextrins. In this paper, the encapsulation of different cyclodextrins with rutin was investigated using a combination of experimental and simulation methods. Three inclusions of rutin/beta-cyclodextrin (β-CD), rutin/2-hydroxypropyl beta-cyclodextrin (HP-β-CD) and rutin/2,6-dimethyl beta-cyclodextrin (DM-β-CD) were prepared by the freeze-drying method,

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12

Smita, Nagar, Neetesh Kumar Jain Dr., Sachin Jain Dr., Sharma Rajesh, and Nagar Deepika. "Solubility Enhancement for some BCS Class IV Drug." Chemistry Research Journal 8, no. 1 (2023): 1–11. https://doi.org/10.5281/zenodo.11296388.

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<strong>Abstract </strong>In the present study, inclusion complexes of Gamma oryganol were developed with β-cyclodextrin (β-CD) and hydroxy propyl β-cyclodextrin (HPβ-CD). The complexes were prepared by kneading and solvent evaporation. Inclusion complexes of Gamma oryganol with both β-CD and HPβ-CD in aqueous solution were evaluated by phase solubility study. The phase solubility diagram with both the complexing agent was classified as A<sub>L</sub>-type, indicating the formation of 1:1 steriochiometric inclusion complex. The apparent complexation constant o

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13

CORCIOVĂ, Andreia, Bianca IVĂNESCU, Daniela Carmen ABABEI, Ana Flavia BURLEC, Cornelia MIRCEA, and Veronica BILD. "In vivo antinociceptive and anti-inflammatory potential of hesperidin and its cyclodextrin inclusion compounds." Balneo and PRM Research Journal 12, Vol.12, no.1 (2021): 40–45. http://dx.doi.org/10.12680/balneo.2021.417.

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Introduction. This study aims to evaluate the antinociceptive activity on inflammatory and non-inflammatory nociception models, as well as the anti-inflammatory action of hesperidin and its inclusion compounds with beta-cyclodextrin and hydroxypropyl-beta-cyclodextrin. Material and method. For these experiments, we employed nociception models using thermal, chemical and pressure stimuli and an inflammation model for the evaluation of inflammatory edema by plethysmometer test. Results and discussions. The obtained results demonstrate that the HES-βCD inclusion compounds exhibited antinociceptiv

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14

Wu, Hsien-Tsung, Yao-Hsiang Chuang, Han-Cyuan Lin, Tzu-Chieh Hu, Yi-Jia Tu, and Liang-Jung Chien. "Immediate Release Formulation of Inhaled Beclomethasone Dipropionate-Hydroxypropyl-Beta-Cyclodextrin Composite Particles Produced Using Supercritical Assisted Atomization." Polymers 14, no. 10 (2022): 2114. http://dx.doi.org/10.3390/polym14102114.

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In this study, the enhanced solubilization performance of a poorly soluble drug, beclomethasone dipropionate (BDP), was investigated using hydroxypropyl-β-cyclodextrin (HP-β-CD) and ethanol. The enhanced solubility of the drug was determined using the phase solubility method and correlated as a function of both HP-β-CD and ethanol concentrations. The effective progress of drug solubility originated from the formation of cyclodextrin and BDP inclusion complexes and increase in the lipophilicity of the medium, by aqueous ethanol, for hydrophobic BDP. BDP and HP-β-CD composite particles were prod

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15

M., Jude Jenita, Venkatesh G., Antony Muthu Prabhu A., and Rajendiran N. "Inclusion complex formation of omeprazole with hydroxypropyl cyclodextrins." Journal of Indian Chemical Society Vol. 90, Aug 2013 (2013): 1195–206. https://doi.org/10.5281/zenodo.5787941.

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Department of Chemistry, Annamalai University, Annamalainagar-608 002, Tamilnadu, India <em>E-mail</em> : drrajendiran@rediffmail.com     Fax : 91-4144-238080 <em>Manuscript received online 02 May 2012, revised 08 October 2012, accepted 10 October 2012</em> The effects of hydtoxypropyl-α-cyclodextrin (HP-α-CD) and hydroxypropyl-β-cyclodextrin (HP-β-CD) on the twisted intramolecular charge transfer (TICT) emission of omeprazole (OMP) in aqueous solution were investigated by absorption and steady-state and time-resolved fluorescence techniques. The short

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16

Al-Khedairy, Eman B. H., and Sura Salam Hatam. "Formulation and Characterization of Bilastine – Ternary Cyclodextrin Inclusion Complex." Iraqi Journal of Pharmaceutical Sciences 34, no. 1 (2025): 143–55. https://doi.org/10.31351/vol34iss1pp143-155.

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Abstract Bilastine (BLA) is a modern second – generation antihistamine employed to manage symptoms associated with allergic rhinoconjuctivitis and urticaria. However, it is very slightly soluble in water with low bioavailability, which affects its therapeutic action. The main objective of this research was to enhance the solubility and dissolution rate of BLA by complexation technique using beta cyclodextrin)β-CD) and its derivatives, hydroxypropyl beta cyclodextrin) HP-β-CD), methyl beta cyclodextrin(M-β-CD), and sulfobutyl ether beta cyclodextrin (SBE-β- CD) . Binary and ternary complexes us

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17

Kou, Xingran, Xinping Zhang, Ying Cheng, Miao Yu, Qingran Meng, and Qinfei Ke. "Mannitol Is a Good Anticaking Agent for Spray-Dried Hydroxypropyl-Beta-Cyclodextrin Microcapsules." Molecules 28, no. 3 (2023): 1119. http://dx.doi.org/10.3390/molecules28031119.

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Agglomeration is an undesirable phenomenon that often occurs in spray-dried microcapsules powder. The objective of this work is to determine the best solution for spray-dried hydroxypropyl-β-cyclodextrin (HP-β-CD) microcapsules from four anticaking agents, namely calcium stearate (CaSt), magnesium stearate (MgSt), silicon dioxide (SiO2), and mannitol (MAN), and to explore their anticaking mechanisms. Our results showed that MAN was found to be the superior anticaking agent among those tested. When the MAN ratio is 12%, the microcapsules with a special Xanthium-type shape had higher powder flow

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18

Li, Jinxia. "Study and Characterization of the Antioxidant Activity of the Inclusion Complex of Apigenin with beta-Cyclodextrin and HP-beta-Cyclodextrin in solution." Journal of Investigational Biochemistry 3, no. 3 (2014): 107. http://dx.doi.org/10.5455/jib.20140905032504.

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19

Tran, Thi H. Yen, Thi T. Giang Vu, and Thi M. H. Pham. "Preparation and Characterization of Liposomes Double-loaded with Amphotericin B and Amphotericin B/hydroxypropyl-beta-cyclodextrin Inclusion Complex." Pharmaceutical Nanotechnology 9, no. 3 (2021): 236–44. http://dx.doi.org/10.2174/2211738509666210310160436.

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Background: Amphotericin B (AMB) is water-insoluble polyene, which has a broad spectrum of antifungal activity. The hydrophobic drug only exits in the phospholipid bilayer, leading to a low-drug liposomal loading capacity. Objectives: This study is designed to prepare water-soluble inclusion complex (IC) between AMB and cyclodextrin (CD) to formulate liposomal vesicles, double-loaded with drug molecules in the phospholipid bilayer and AMB/CD IC in the aqueous core. Methods: Water-soluble AMB/CD IC was prepared by pH adjustment of the aqueous media and consequently characterized by scanning ele

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20

Aziz, Ghaith M., and Eman B. H. Al-Khedairy. "Solubility and Dissolution Enhancement of Candesartan Cilexetil by Complexation with Cyclodextrin." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 14, no. 01 (2024): 257–64. http://dx.doi.org/10.25258/ijddt.14.1.37.

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At present, numerous novel chemical compounds face challenges related to their limited solubility in aqueous environments. These compounds are classified under the Biopharmaceutical Classification System (BCS) as either class II or class IV substances. Different carriers were used to increase their solubility. Candesartan cilexetil (CC) is one of the most widely used antihypertensive drugs, which belongs to class II drugs. The aim of this research was to enhance the solubility and dissolution rate of CC through a complexation approach involving β-cyclodextrin and its derivatives, specifically

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Said Suliman, Ammar, Mouhamad Khoder, Ibrahim Tolaymat, et al. "Cyclodextrin Diethyldithiocarbamate Copper II Inclusion Complexes: A Promising Chemotherapeutic Delivery System against Chemoresistant Triple Negative Breast Cancer Cell Lines." Pharmaceutics 13, no. 1 (2021): 84. http://dx.doi.org/10.3390/pharmaceutics13010084.

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Diethyldithiocarbamate Copper II (DDC-Cu) has shown potent anticancer activity against a wide range of cancer cells, but further investigations are hindered by its practical insolubility in water. In this study, inclusion complexes of DDC-Cu with hydroxypropyl beta-cyclodextrin (HP) or sulfobutyl ether beta-cyclodextrin (SBE) were prepared and investigated as an approach to enhance the apparent solubility of DDC-Cu. Formulations were prepared by simple mixing of DDC-Cu with both cyclodextrin (CDs) at room temperature. Phase solubility assessments of the resulting solutions were performed. DDC-

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Said Suliman, Ammar, Mouhamad Khoder, Ibrahim Tolaymat, et al. "Cyclodextrin Diethyldithiocarbamate Copper II Inclusion Complexes: A Promising Chemotherapeutic Delivery System against Chemoresistant Triple Negative Breast Cancer Cell Lines." Pharmaceutics 13, no. 1 (2021): 84. http://dx.doi.org/10.3390/pharmaceutics13010084.

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Diethyldithiocarbamate Copper II (DDC-Cu) has shown potent anticancer activity against a wide range of cancer cells, but further investigations are hindered by its practical insolubility in water. In this study, inclusion complexes of DDC-Cu with hydroxypropyl beta-cyclodextrin (HP) or sulfobutyl ether beta-cyclodextrin (SBE) were prepared and investigated as an approach to enhance the apparent solubility of DDC-Cu. Formulations were prepared by simple mixing of DDC-Cu with both cyclodextrin (CDs) at room temperature. Phase solubility assessments of the resulting solutions were performed. DDC-

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23

Choudhary, Nisha, Dipika Chavda, Vaishali Thakkar, and Tejal Gandhi. "Identification of Critical Factors Influencing the In-Vitro Dissolution o f Bicalutamide Tablets Prepared Using Madg Technique." Journal of Pharmaceutical Research 21, no. 1 (2022): 27–37. http://dx.doi.org/10.18579/jopcr/v21i1.ms21.81.

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This study was aimed to utilize the Moisture Activated Dry Granulation (MADG) technique to formulate Bicalutamide tablet and identify critical factors influencing its dissolution. The Bicalutamide inclusion complex was formed using the kneading method. Aeroperl 300 was selected as an adsorbent, polyvinylpyrrolidone (PVP) K30 as a binder, Microcrystalline Cellulose (MCC) and Lactose Monohydrate (LMH) in1:1 ratio as fillers. Croscarmellose sodium (CCS) and neusilin were used as disintegrating agents, as they did not affect the disintegration time when hardness and compression force increased. Bo

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Serna-Escolano, Vicente, María Serrano, Daniel Valero та ін. "Thymol Encapsulated into HP-β-Cyclodextrin as an Alternative to Synthetic Fungicides to Induce Lemon Resistance against Sour Rot Decay". Molecules 25, № 18 (2020): 4348. http://dx.doi.org/10.3390/molecules25184348.

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Consumers demand the use of eco-friendly fungicides to treat fruit and vegetables and governmental authorities have unauthorized the application of chemical antifungals for the efficient control of sour rot. In the present research, the microwave irradiation (MW) method was used to encapsulate thymol into 2-hydroxylpropyl-beta-cyclodextrin (HP-β-CD) and the effect of these HP-β-CD on controlling sour rot in citrus fruit, caused by Geotrichum citri-aurantii, was evaluated. Amounts of 25 and 50 mM of HP-β-CD-thymol were used, and compared with propiconazole, to control the decay of inoculated le

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Bezerra, Bruno Braz, Gustavo Peixoto Duarte da Silva, Sharton Vinicius Antunes Coelho, et al. "Hydroxypropyl-beta-cyclodextrin (HP-BCD) inhibits SARS-CoV-2 replication and virus-induced inflammatory cytokines." Antiviral Research 205 (September 2022): 105373. http://dx.doi.org/10.1016/j.antiviral.2022.105373.

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26

Malhotra, Sakshi, Anubha Khare, Kanchan Grover, Inderbir Singh, and Pravin Pawar. "Design and Evaluation of Voriconazole Eye Drops for the Treatment of Fungal Keratitis." Journal of Pharmaceutics 2014 (April 30, 2014): 1–9. http://dx.doi.org/10.1155/2014/490595.

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Voriconazole is a novel antifungal agent with excellent broad spectrum activity commercially available for oral and intravenous administration. The purpose of this study was to prepare ophthalmic formulation of hydroxypropyl beta cyclodextrin (HP-β-CD) based voriconazole containing benzalkonium chloride BAK and EDTA with or without viscosity modifiers and study its permeation characteristics through freshly excised goat cornea. The results were observed that viscosity and force of bioadhesion of the voriconazole HP-β-CD solutions containing xanthan gum (XG) are more as compared to polyvinyl al

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Couto, Verônica Muniz, Laura de Oliveira-Nascimento, Luiz Fernando Cabeça, et al. "Capsaicin-Cyclodextrin Complex Enhances Mepivacaine Targeting and Improves Local Anesthesia in Inflamed Tissues." International Journal of Molecular Sciences 21, no. 16 (2020): 5741. http://dx.doi.org/10.3390/ijms21165741.

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Acidic environments, such as in inflamed tissues, favor the charged form of local anesthetics (LA). Hence, these drugs show less cell permeation and diminished potency. Since the analgesic capsaicin (CAP) triggers opening of the TRPV1 receptor pore, its combination with LAs could result in better uptake and improved anesthesia. We tested the above hypothesis and report here for the first time the analgesia effect of a two-drug combination (LA and CAP) on an inflamed tissue. First, CAP solubility increased up to 20 times with hydroxypropyl-beta-cyclodextrin (HP-β-CD), as shown by the phase solu

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Sharif, Niloufar, Mohammad-Taghi Golmakani, Mehrdad Niakousari, Seyed Hosseini, Behrouz Ghorani, and Amparo Lopez-Rubio. "Active Food Packaging Coatings Based on Hybrid Electrospun Gliadin Nanofibers Containing Ferulic Acid/Hydroxypropyl-Beta-Cyclodextrin Inclusion Complexes." Nanomaterials 8, no. 11 (2018): 919. http://dx.doi.org/10.3390/nano8110919.

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In this work, hybrid gliadin electrospun fibers containing inclusion complexes of ferulic acid (FA) with hydroxypropyl-beta-cyclodextrins (FA/HP-β-CD-IC) were prepared as a strategy to increase the stability and solubility of the antioxidant FA. Inclusion complex formation between FA and HP-β-CD was confirmed by Fourier transform infrared spectroscopy (FTIR), differential scanning calorimeter (DSC), and X-ray diffraction (XRD). After adjusting the electrospinning conditions, beaded-free fibers of gliadin incorporating FA/HP-β-CD-IC with average fiber diameters ranging from 269.91 ± 73.53 to 27

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Hitendra, S. Mahajan. "Development and Evaluation of Rutin-HPβCD Inclusion Complex Based Mouth Dissolving Tablets". International Journal of Pharmaceutical Sciences and Developmental Research 3, № 1 (2018): 001–6. https://doi.org/10.17352/ijpsdr.000009.

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The objective of the present study was to explore inclusion complex of Rutin to improve the aqueous solubility and dissolution rate along with rapid mouth dissolving tablets for oral drug delivery. Rutin is a BCS class II drug having low aqueous solubility and therefore low oral bioavailability. In the present study, inclusion complex of rutin with hydroxypropyl-b-cyclodextrin were prepared by kneading method. Inclusion complex were characterized by 1H NMR, X-ray diffractometry (XRD), differential scanning calorimetry (DSC) studies, and Fourier transform infrared spectroscopy and evaluated for

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Ajaz, Nyla, Anum Abbas, Rabia Afshan та ін. "In Vitro and In Vivo Evaluation of Hydroxypropyl-β-cyclodextrin-grafted-poly(acrylic acid)/poly(vinyl pyrrolidone) Semi-Interpenetrating Matrices of Dexamethasone Sodium Phosphate". Pharmaceuticals 15, № 11 (2022): 1399. http://dx.doi.org/10.3390/ph15111399.

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In this paper, we fabricated semi-interpenetrating polymeric network (semi-IPN) of hydroxypropyl-β-cyclodextrin-grafted-poly(acrylic acid)/poly(vinyl pyrrolidone) (HP-β-CD-g-poly(AA)/PVP) by the free radical polymerization technique, intended for colon specific release of dexamethasone sodium phosphate (DSP). Different proportions of polyvinyl pyrrolidone (PVP), acrylic acid (AA), and hydroxypropyl-beta-cyclodextrin (HP-β-CD) were reacted along with ammonium persulphate (APS) as initiator and methylene-bis-acrylamide (MBA) as crosslinker to develop a hydrogel system with optimum swelling at di

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Avinash, Gupta, Sharma Vijay, Sharma Ashutosh, K. Gupta Manish, and Jaiswal Praveen. "Proportional Assessment of Oral Tablets Having Complex of Cyclodextrin And BCS Class II Drugs." International Journal of Toxicological and Pharmacological Research 11, no. 1 (2021): 9–16. https://doi.org/10.5281/zenodo.12678858.

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Today in Pharma area it turns into an extreme wok to make a formula of active molecules having poor water dissolvability. This explanation, that at present different beneficial active molecules don’t go to the market because of less disintegration and at last less bioavailability. According to the BCS classifications drugs like Elvitegravir which has a place with class II have the less solvency and great penetrability. In this way, it turns into a basic test for a formulator, to figure these medications having the whimsical or non-uniform medication discharge profile, drug retention infl

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Jin, Longhao, Kyeongsoon Park, Yihyun Yoon, et al. "Visible Light-Cured Antibacterial Collagen Hydrogel Containing Water-Solubilized Triclosan for Improved Wound Healing." Materials 14, no. 9 (2021): 2270. http://dx.doi.org/10.3390/ma14092270.

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Infection is one of several factors that can delay normal wound healing. Antibacterial wound dressings can therefore promote normal wound healing. In this study, we prepared an antibacterial wound dressing, consisting of visible light-cured methacrylated collagen (ColMA) hydrogel and a 2-hydroxypropyl-beta-cyclodextrin (HP-β-CD)/triclosan (TCS) complex (CD-ic-TCS), and evaluated its wound healing effects in vivo. The 1H NMR spectra of ColMA and CD-ic-TCS revealed characteristic peaks at 1.73, 5.55, 5.94, 6.43, 6.64, 6.84, 6.95, 7.31, and 7.55 ppm, indicating successful preparation of the two m

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Alzweiri, Muhammad, Mariam Sallam, Walid Al-Zyoud, and Khaled Aiedeh. "Stability Study of Etoricoxib a Selective Cyclooxygenase-2 Inhibitor by a New Single and Rapid Reversed Phase HPLC Method." Symmetry 10, no. 7 (2018): 288. http://dx.doi.org/10.3390/sym10070288.

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Cyclooxygenase-2 (COX-2) is an enzyme responsible for inflammation and pain. Etoricoxib is the most recent selective (COX-2) inhibitor that has a higher COX-2 selectivity than the other COX-2-selective nonsteroidal anti-inflammatory drugs (NSAIDs), which significantly improves its gastric safety profile. The current therapeutic indications of etoricoxib includes the treatment of several painful conditions, such as osteoarthritis, acute gout, ankylosing spondylitis, and rheumatoid arthritis. To the best of found knowledge, no decent method has been reported that can be used for the routine dete

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Escobar-Avello, Danilo, Javier Avendaño-Godoy, Jorge Santos, et al. "Encapsulation of Phenolic Compounds from a Grape Cane Pilot-Plant Extract in Hydroxypropyl Beta-Cyclodextrin and Maltodextrin by Spray Drying." Antioxidants 10, no. 7 (2021): 1130. http://dx.doi.org/10.3390/antiox10071130.

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Grape canes, the main byproducts of the viticulture industry, contain high-value bioactive phenolic compounds, whose application is limited by their instability and poorly solubility in water. Encapsulation in cyclodextrins allows these drawbacks to be overcome. In this work, a grape cane pilot-plant extract (GCPPE) was encapsulated in hydroxypropyl beta-cyclodextrin (HP-β-CD) by a spray-drying technique and the formation of an inclusion complex was confirmed by microscopy and infrared spectroscopy. The phenolic profile of the complex was analyzed by LC-ESI-LTQ-Orbitrap-MS and the encapsulatio

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Ahmed, Tarek A., Khalid M. El-Say, Fathy I. Abd-Allah, et al. "Improving the Solubility and Oral Bioavailability of a Novel Aromatic Aldehyde Antisickling Agent (PP10) for the Treatment of Sickle Cell Disease." Pharmaceutics 13, no. 8 (2021): 1148. http://dx.doi.org/10.3390/pharmaceutics13081148.

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Background: Aromatic aldehydes, with their ability to increase the oxygen affinity of sickle hemoglobin, have become important therapeutic agents for sickle cell disease (SCD). One such compound, voxelotor, was recently approved for SCD treatment. Methyl 6-((2-formyl-3-hydroxyphenoxy)methyl) picolinate (PP10) is another promising aromatic aldehyde, recently reported by our group. Like voxelotor, PP10 exhibits O2-dependent antisickling activity, but, unlike voxelotor, PP10 shows unique O2-independent antisickling effect. PP10, however, has limited solubility. This study therefore aimed to devel

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Hassan, Abeer S., and Ghareb M. Soliman. "Rutin Nanocrystals with Enhanced Anti-Inflammatory Activity: Preparation and Ex Vivo/In Vivo Evaluation in an Inflammatory Rat Model." Pharmaceutics 14, no. 12 (2022): 2727. http://dx.doi.org/10.3390/pharmaceutics14122727.

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Rutin is a polyphenolic flavonoid with an interestingly wide therapeutic spectrum. However, its clinical benefits are limited by its poor aqueous solubility and low bioavailability. In an attempt to overcome these limitations, rutin nanocrystals were prepared using various stabilizers including nonionic surfactants and nonionic polymers. The nanocrystals were evaluated for particle size, zeta potential, drug entrapment efficiency, morphology, colloidal stability, rutin photostability, dissolution rate, and saturation solubility. The selected nanocrystal formulation was dispersed in a hydrogel

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Ou, Chun-Wei, Aravindan Santhan та Cheng-Han Wang. "Rational Construction of Hp-β-Cd Enriched RGO Reinforced Zinc Oxide as an Active Catalyst for the Electrochemical Monitoring of Melatonin in Biological Samples". ECS Meeting Abstracts MA2025-01, № 59 (2025): 2790. https://doi.org/10.1149/ma2025-01592790mtgabs.

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Rational C onstruction of Hp-β-cd E nriched rGO R einforced Z inc O xide as an A ctive C atalyst for the E lectrochemical M onitoring of M elatonin in B iological S amples Chun-Wei Oub, Aravindan Santhana,b, Cheng-Han Wang b andKuo-Yuan Hwa a,b,c* aDepartment of Molecular Science and Engineering, National Taipei University of Technology, Taipei, Taiwan (ROC). bGraduate Institute of Organic and Polymeric Materials, National Taipei University of Technology, Taipei, Taiwan (ROC). cCollege of Engineering, National Taipei University of Technology, Taipei, Taiwan (ROC). Developing hydroxypropyl beta

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Imam, Syed Sarim, Sultan Alshehri, Talal Abdullah Alzahrani, Afzal Hussain та Mohammad A. Altamimi. "Formulation and Evaluation of Supramolecular Food-Grade Piperine HP β CD and TPGS Complex: Dissolution, Physicochemical Characterization, Molecular Docking, In Vitro Antioxidant Activity, and Antimicrobial Assessment". Molecules 25, № 20 (2020): 4716. http://dx.doi.org/10.3390/molecules25204716.

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The purpose of the present study was to improve the aqueous solubility, dissolution, and antioxidant activity of the water-insoluble drug piperine (PIP). The study was performed by preparing PIP binary inclusion complex (PIP BIC) and piperine ternary inclusion complex (PIP TIC) by different methods. The effect of a hydrophilic auxiliary substance (TPGS) was assessed with addition to PIP and hydroxypropyl beta cyclodextrin (HP β CD) complex. The phase solubility study was performed to evaluate the complexation efficiency and stability constant. The aqueous solubility, dissolution, physicochemic

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Kanekar, H., A. Khale, S. Maurya, and B. Dey. "PHASE SOLUBILITY STUDIES OF ONDANSETRON -2- HYDROXYPROPYL BETACYCLODEXTRIN FOR DEVELOPMENT OF ONDANSETRON ORODISPERSIBLE FILMS." INDIAN DRUGS 53, no. 08 (2016): 53–56. http://dx.doi.org/10.53879/id.53.08.10589.

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The present research work was aimed to formulate transparent mouth dissolving films of ondansetron. Ondansetron is poorly soluble in aqueous solvents (less than 5 mg/mL) and thus improvisation in solubility was crucial. The phase solubility studies were carried in order to study the formation of inclusion complex with Hydroxy Propyl Beta cyclodextrin. The phase solubility diagrams revealed the formation of stable inclusion complex and apparent stability constants were evaluated. The calculated apparent stability constant, Kc was found to be 288.5 mol-1. The shape of solubility graph indicated

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Piel, G. "In vitro comparison of the antimycotic activity of a miconazole-HP-beta-cyclodextrin solution with a miconazole surfactant solution." Journal of Antimicrobial Chemotherapy 48, no. 1 (2001): 83–87. http://dx.doi.org/10.1093/jac/48.1.83.

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Farkas, Eszter, Houssam Abboud, Nándor Nagy, et al. "Formulation and Development of Nanofiber-Based Ophthalmic Insert for the Treatment of Bacterial Conjunctivitis." International Journal of Molecular Sciences 25, no. 17 (2024): 9228. http://dx.doi.org/10.3390/ijms25179228.

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A novel ophthalmic delivery system utilizing levofloxacin-loaded, preservative-free, nanofiber-based inserts was investigated. Polyvinyl alcohol (PVA) and Poloxamer 407 (Polox)were employed as matrix materials, while hydroxypropyl-beta-cyclodextrin (HP-β-CD) was a solubilizer. The formulations were prepared via electrospinning and characterized for fiber morphology, drug dissolution, cytotoxicity, and antimicrobial activity. Scanning electron microscopy confirmed uniform fibrous structures. Fourier Transform Infrared spectroscopy and X-ray diffraction analyses demonstrated the amorphous state

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Diaz-Salmeron, Raul, Balthazar Toussaint, Nicolas Huang та ін. "Mucoadhesive Poloxamer-Based Hydrogels for the Release of HP-β-CD-Complexed Dexamethasone in the Treatment of Buccal Diseases". Pharmaceutics 13, № 1 (2021): 117. http://dx.doi.org/10.3390/pharmaceutics13010117.

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Oral lichen planus (OLP) is an ongoing and chronic inflammatory disease affecting the mucous membrane of the oral cavity. Currently, the treatment of choice consists in the direct application into the buccal cavity of semisolid formulations containing a corticosteroid molecule to decrease inflammatory signs and symptoms. However, this administration route has shown various disadvantages limiting its clinical use and efficacy. Indeed, the frequency of application and the incorrect use of the preparation may lead to a poor efficacy and limit the treatment compliance. Furthermore, the saliva clea

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Kuplennik, Nataliya, and Alejandro Sosnik. "Enhanced Nanoencapsulation of Sepiapterin within PEG-PCL Nanoparticles by Complexation with Triacetyl-Beta Cyclodextrin." Molecules 24, no. 15 (2019): 2715. http://dx.doi.org/10.3390/molecules24152715.

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In this work, we aimed to improve the encapsulation efficiency of sepiapterin (SP), the natural precursor of the essential cofactor tetrahydrobiopterin (BH4) that displays mild water-solubility and a short biological half-life, within methoxy-poly(ethylene-glycol)-poly(epsilon-caprolactone)(mPEG-PCL) nanoparticles (NPs) by means of its complexation and hydrophobization with 2,3,6-triacetyl-β-cyclodextrin (TAβCD). For this, SP/TAβCD complexes were produced by spray-drying of SP/TAβCD binary solutions in ethanol using the Nano Spray Dryer B-90 HP. Dry powders were characterized by differential s

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Dudhipala, Narendar, Swetha Ettireddy, Ahmed Adel Ali Youssef, and Goverdhan Puchchakayala. "Cyclodextrin Complexed Lipid Nanoparticles of Irbesartan for Oral Applications: Design, Development, and In Vitro Characterization." Molecules 26, no. 24 (2021): 7538. http://dx.doi.org/10.3390/molecules26247538.

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Irbesartan (IR) is an angiotensin II receptor antagonist drug with antihypertensive activity. IR bioavailability is limited due to poor solubility and first-pass metabolism. The current investigation aimed to design, develop, and characterize the cyclodextrin(s) (CD) complexed IR (IR-CD) loaded solid lipid nanoparticles (IR-CD-SLNs) for enhanced solubility, sustained release behavior, and subsequently improved bioavailability through oral administration. Based on phase solubility studies, solid complexes were prepared by the coacervation followed by lyophilization method and characterized for

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Pereira, Ana Maria, Ayse Kaya, Dan Alves, et al. "Preparation and Characterization of Disulfiram and Beta Cyclodextrin Inclusion Complexes for Potential Application in the Treatment of SARS-CoV-2 via Nebulization." Molecules 27, no. 17 (2022): 5600. http://dx.doi.org/10.3390/molecules27175600.

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Disulfiram (DS), known as an anti-alcoholism drug, has shown a potent antiviral activity. Still, the potential clinical application of DS is limited by its low water solubility and rapid metabolism. Cyclodextrins (CDs) have been widely used to improve the solubility of drugs in water. In this study, five concentrations of hydroxypropyl β-cyclodextrin (HP) and sulfobutyl ether β-cyclodextrin (SBE) were used to form inclusion complexes of DS for enhanced solubility. Solutions were freeze-dried, and the interaction between DS and CD was characterized using differential scanning calorimetry (DSC),

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Rodriguez-Perez, A. I., C. Rodriguez-Tenreiro, C. Alvarez-Lorenzo, A. Concheiro, and J. J. Torres-Labandeira. "Drug Solubilization and Delivery from Cyclodextrin-Pluronic Aggregates." Journal of Nanoscience and Nanotechnology 6, no. 9 (2006): 3179–86. http://dx.doi.org/10.1166/jnn.2006.472.

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Colloidal systems based on Pluronic® F127 (PF127) and hydroxypropyl-beta-cyclodextrin (HPβCD) have been characterized with a view to their potential use as delivery systems of hydrophobic drugs. Complexation of PF127 and HPβCD was evaluated by surface tension measurements, 1H-NMR spectroscopy and transmission electron microscopy. The critical micellar concentration, CMC, at 25 °C of PF127 (0.39 mM in pH 5.8 and 7.4 phosphate buffers, and 0.59 mM in pH 4.5 acetic/acetate and lactic/lactate buffers) was shifted to higher values by the addition of 38.17 mM HP CD (CMCapp = 1.18 mM). This is relate

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Kuevi, Deryl Nii Okantey, Francis Asiedu Acquah, Amy Amuquandoh, and Andrew Papa Abbey. "Challenges and Proven Recommendations of Praziquantel Formulation." Journal of Clinical Pharmacy and Therapeutics 2023 (October 16, 2023): 1–7. http://dx.doi.org/10.1155/2023/3976392.

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Background. Schistosomiasis, ranked second to malaria as one of the crucial parasitic infections in the world, infects close to 240 million people as at 2019. Praziquantel, an oral anthelmintic, is the first-line drug for the treatment of schistosomiasis. Although the drug is safe and effective, the formulated tablets come with some limitations such as low bioavailability and bitter taste. This literature review aims to provide information on how to improve the issues of solubility, low bioavailability, and bitter taste associated with the praziquantel formulation and, subsequently, to be help

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Craparo, Emanuela Fabiola, Salvatore Emanuele Drago, Gabriella Costabile, et al. "Sustained-Release Powders Based on Polymer Particles for Pulmonary Delivery of Beclomethasone Dipropionate in the Treatment of Lung Inflammation." Pharmaceutics 15, no. 4 (2023): 1248. http://dx.doi.org/10.3390/pharmaceutics15041248.

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Inhaled corticosteroids are the mainstay in the management of lung inflammation associated to chronic lung diseases, such as asthma and chronic obstructive pulmonary disease (COPD). Nonetheless, available inhalation products are mostly short-acting formulations that require frequent administrations and do not always produce the desired anti-inflammatory effects. In this work, the production of inhalable beclomethasone dipropionate (BDP) dry powders based on polymeric particles was attempted. As starting material, the PHEA-g-RhB-g-PLA-g-PEG copolymer was chosen, obtained by grafting 0.6, 2.4 an

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Kaya, Ayşe, Basel Arafat, Havovi Chichger, et al. "Preparation and Characterisation of Zinc Diethyldithiocarbamate–Cyclodextrin Inclusion Complexes for Potential Lung Cancer Treatment." Pharmaceutics 16, no. 1 (2023): 65. http://dx.doi.org/10.3390/pharmaceutics16010065.

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Zinc diethyldithiocarbamate (Zn (DDC)2), a disulfiram metabolite (anti-alcoholism drug), has shown a strong anti-cancer activity in vitro. However, its application was limited by its low aqueous solubility and rapid metabolism. In this study, the solubility enhancement of Zn (DDC)2 is investigated by forming inclusion complexes with cyclodextrins. The inclusion complexes were prepared using two different types of beta-cyclodextrins, SBE-CD and HP-CD. Phase solubility diagrams for the resulting solutions were assessed; subsequently, the solutions were freeze-dried for further characterisation s

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M., Jude Jenita, Antony Muthu Prabhu A. та Rajendiran N. "Encapsulation of 3,5-dihydroxybenzoic acid and 3,4,5-trihydroxybenzoic acid by α- and β -cyclodextrins : Spectral and theoretical studies". Journal of Indian Chemical Society Vol. 91, Sep 2014 (2014): 1711–30. https://doi.org/10.5281/zenodo.5733117.

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Department of Chemistry, Annamalai University, Annamalainagar-608 002, Tamilnadu, India <em>E-mail</em> : drrajendiran@rediffmail.com <em>Manuscript received online 22 February 2014, accepted 06 April 2014</em> Inclusion complex formation of α-CD, β-CD, hydroxy propyl-α-CD (Hp-α-CD) and hydroxy propyl-β-CD (Hp-β-CD) of 3,5-dihydroxybenzoic acid (DHBA) and 3,4,5-trihydroxybenzoic acid (THBA) were investigated. The inclusion complexes of both guest molecules with the four CDs were analysed by UV-Visible, steady state and time resolved fluorescence, FTIR, <sup>1</

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