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Dissertations / Theses on the topic 'HPLC/ms/ms'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Bakirdere, Sezgin. "Speciation Studies Using Hplc-icp-ms And Hplc-es-ms." Phd thesis, METU, 2009. http://etd.lib.metu.edu.tr/upload/3/12611391/index.pdf.

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Knowledge about selenium content of foods containing selenium species is very important in terms of both nutrition and toxicity. Bioavailability of selenium species for human body is different from each other. Hence, speciation of selenium is more important than total selenium determination. In the selenium speciation study, chicken breast samples, selenium supplement tablets and egg samples were analyzed for their selenium contents. In chicken breast study, chickens were randomly categorized into three groups including the control group (25 chickens), inorganic selenium fed group (25 chickens

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2

Käsmä, S. (Salla). "(U)HPLC-MS/MS käyttö virtsanäytteiden steroidianalyyseissä." Bachelor's thesis, University of Oulu, 2019. http://urn.fi/URN:NBN:fi:oulu-201901121055.

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Kehossa esiintyy luontaisesti useita anabolisia androgeenisia steroidiyhdisteitä, joista lihasmassan kasvun ja sen ylläpidon kannalta merkittävin on testosteroni. Testosteronin voimakkaan anabolisen vaikutuksen takia siitä on tehty useita muunnelma, joilla on pyritty minimoimaan androgeenista vaikutusta, maksimoimaan anabolista tehoa ja esimerkiksi vaikuttamaan yhdisteen vapautumiseen kehossa. Luontaisetja synteettiset anaboliset androgeenit ovat sekä rakenteeltaan että toiminnaltaan testosteronin kaltaisia. Anabolisten androgeenien ja muiden steroidiyhdisteiden aineenvaihdunta on monimutkaist

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3

Berger, Irayani. "HPLC-MS/MS Analyse von Immunsuppressiva direkt in Vollblut." Diss., lmu, 2010. http://nbn-resolving.de/urn:nbn:de:bvb:19-127030.

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4

Zhong, Fanyi. "DEVELOPMENT AND APPLICATIONS OF HPLC-MS/MS BASED METABOLOMICS." Miami University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=miami1524792637748877.

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5

Berger, Irayani [Verfasser]. "HPLC-MS/MS Analyse von Immunsuppressiva direkt in Vollblut / Irayani Berger." München : Verlag Dr. Hut, 2011. http://d-nb.info/1010446894/34.

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6

Wollersen, Heike. "Bestimmung und Identifizierung von Flavonoiden in Gerste mit HPLC-DAD-MS/MS." [S.l. : s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=971821453.

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7

Levaggi, Valeria <1991&gt. "Caratterizzazione chimica del tabacco lavorato (Nicotiana Tabacum, tipo Kentucky) attraverso un approccio analitico multi-metodologico (ICP-MS, GC-MS, HPLC-MS-MS)." Master's Degree Thesis, Università Ca' Foscari Venezia, 2019. http://hdl.handle.net/10579/15053.

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Il presente lavoro di tesi ha l’obiettivo di studiare dal punto di vista chimico, il tabacco “kentucky” coltivato e lavorato in alcune zone della Regione Veneto. Questo tipo di produzione agricola è considerata di nicchia e la caratterizzazione e quantificazione dei suoi principali costituenti chimici non è mai stata approfondita. Nel presente lavoro di tesi si sono individuati alcuni componenti chimici sviluppando e/o perfezionando metodi analitici utili all’individuazione di una "impronta digitale" chimica del tabacco Kentucky veneto. Il Kentucky è un tabacco scuro appartenente alla classe d

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8

McCulloch, Melissa. "Development of Quantitative Bioanalytical Methods for the Measurement of Pharmaceutical Compounds via HPLC-UV and HPLC-MS/MS." Cleveland State University / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=csu1255046678.

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9

Mayton, Eric. "Characterization of Lysophosphatidic Acid Subspecies Using a Novel HPLC ESI-MS/MS Method." VCU Scholars Compass, 2011. http://scholarscompass.vcu.edu/etd/2515.

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Lysophosphatidic acid (LPA) is a bioactive lipid with a plethora of biological functions, including roles in cell survival, proliferation, and migration. Although high-performance liquid chromatography electrospray ionization tandem mass spectrometry (HPLC ESI-MS/MS) technology has been used to measure the levels of LPA in human blood, serum and plasma, current methods cannot readily detect the minute levels of LPA from cell culture. In this study, a novel HPLC ESI-MS/MS method with enhanced sensitivity was developed which allows accurate measurements of LPA levels with a limit of quantitation

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10

Shah, Iltaf. "Determination of steroidal and nonsteroidal drugs in human body matrices by LC-MS/MS, GC-MS, HPLC and ELISA." Thesis, Kingston University, 2010. http://eprints.kingston.ac.uk/27839/.

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There is an ever-increasing need to develop analytical methods for the detection of steroids, NSAIDs, fibrates, iothalamates and fatty acids for therapeutic, forensic, medical and pharmaceutical applications. Hence, the primary aim of the project was to develop new methods for detection of these classes of drugs in different human. body matrices using chromatographic techniques like enzyme-linked immunosorbent assay [ELISA], HPLC-UVIDADÆLSD, LC-MS/MS and GC-MS/MS. The new methods developed were capable of detecting the drugs: prednisolone, cortisol, prednisone, nandrolone, stanozolol, testoste

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11

Sealey-Voyksner, Jennifer A. Jorgenson James W. "Investigation of immunogenic gluten peptides identification using enzymatic tagging and HPLC-MSn; analysis and quantification using HPLC-MS/MS /." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2009. http://dc.lib.unc.edu/u?/etd,2764.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2009.<br>Title from electronic title page (viewed Mar. 10, 2010). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Chemistry." Discipline: Chemistry; Department/School: Chemistry.

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12

Cartwright, Andrew James. "Analysis of pharmaceuticals and biomolecules using HPLC coupled to ICP-MS and ESI-MS." Thesis, University of Plymouth, 2005. http://hdl.handle.net/10026.1/1997.

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The work described within this thesis explores the use of HPLC coupled with ICPMS and ESI-MS in order to develop novel methods which overcome specific analytical challenges in the pharmaceutical industry. A membrane desolvation interface has been evaluated for coupling high performance liquid chromatography (HPLC) with inductively coupled plasma mass spectrometry (ICP-MS). Desolvation of the sample prior to reaching the plasma was shown to facilitate a versatile coupling of the two instrumental techniques, enabling chromatographic eluents containing up to 100 % organic to be used. This interfa

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13

Samano, Kimberly L. "Behavioral Assessment and HPLC/MS/MS Identification of the Synthetic Cannabinoid, CP47,497, in Mice." VCU Scholars Compass, 2014. http://scholarscompass.vcu.edu/etd/3328.

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CP47,497 and other synthetic cannabinoid compounds were incipiently synthesized as research tools to investigate the mechanisms by which marijuana affects the brain and to aid in the development of therapeutic agents. Recently, these cannabinoid compounds have resurfaced in the designer drug market, marketed as “herbal incense products” (HIPs). Their popular use has resulted in an alarming rate of reported adverse effects and toxicities. Current legislation classified CP47,497 and several other synthetic cannabinoids compounds as Schedule I agents, but abuse of these compounds persists with se

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14

Eroglu, Ozcan Sefika. "Arsenic Speciation In Fish By Hplc-icp-ms." Master's thesis, METU, 2010. http://etd.lib.metu.edu.tr/upload/12612704/index.pdf.

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ABSTRACT ARSENIC SPECIATION IN FISH BY HPLC-ICP-MS &Ouml<br>ZCAN, Sefika Eroglu M.S., Department of Chemistry Supervisor: Prof. Dr. O. Yavuz ATAMAN September 2010, 103 pages Arsenic speciation in fish samples on the market was performed using isocratic elution with cation exchange column high performance liquid chromatography (HPLC) with inductively coupled plasma mass spectrometry (ICP-MS) detection. Total As concentrations were found by ICP-MS using samples digested by nitric acid-hydrogen peroxide solution using microwave oven digestion<br>the results were in the range of 1.15-12.6

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15

Tevell, Åberg Annica. "Detection and Structure Elucidation of Drug Metabolites in Biological Samples using HPLC-MS/MS Techniques." Doctoral thesis, Uppsala universitet, Avdelningen för analytisk farmaceutisk kemi, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-98348.

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This thesis describes the structure elucidation of drug metabolites in biological samples by the use of high performance liquid chromatography (HPLC) atmospheric pressure ionization (API) tandem mass spectrometry (MS/MS). Due to their different advantages, various mass analyzers have been used in the different experiments. The metabolism of clemastine, flutamide, and meloxicam were studied in vitro and/or in vivo in different species such as humans, dogs, and horses. Accurate mass measurements with the quadrupole-time of flight mass spectrometer and MSn data supplied by the ion trap instrument

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16

Haddad, Renato. "Utilização da tecnica HPLC/APCI-MS/MS para determinação e identificação de danos ao DNA." [s.n.], 2004. http://repositorio.unicamp.br/jspui/handle/REPOSIP/313581.

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Orientadores: Nelci Fenalti Hoehr, Marcos Nogueira Eberlin<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas<br>Made available in DSpace on 2018-08-04T01:26:19Z (GMT). No. of bitstreams: 1 Haddad_Renato_D.pdf: 3564615 bytes, checksum: 5d6ffc7c1ac5fa4d72b2c1664955439c (MD5) Previous issue date: 2004<br>Resumo: o acúmulo de danos oxidativos ao DNA vem sendo proposto como um dos responsáveis pelo envelhecimento e por doenças neurodegenerativas como a doença de A1zheimer. Estudos de danos oxidativos vêm sendo realizados com o objetivo de elucidar diversas doe

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17

LA, MAIDA NUNZIA. "Development and validation of analytical methods with hyphenated chromatographic techniques for the determination of NPS and drugs of abuse in biological matrices." Doctoral thesis, Università Politecnica delle Marche, 2022. https://hdl.handle.net/11566/299808.

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Sin dal 1990 l'apparizione sul mercato di nuove sostanze psicoattive (NPS) è un fenomeno mondiale sempre crescente. Ogni anno vengono introdotte nuove sostanze nel mercato della droga come alternative legali alle sostanze controllate dalla legge. L’identificazione di queste nuove sostanze in matrici biologiche rappresenta una continua sfida per i laboratori di analisi. È estremamente importante sviluppare metodologie analitiche in grado di identificare sostanze sconosciute consentendone il monitoraggio e fornendo informazioni scientifiche riguardo la farmacocinetica, possibili range di tossici

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18

Bellinaso, Laura <1988&gt. "Determinazione degli amminoacidi presenti nei leganti di natura proteica utilizzati nella pittura a tempera. Confronto tra GC-MS e HPLC-MS/MS." Master's Degree Thesis, Università Ca' Foscari Venezia, 2012. http://hdl.handle.net/10579/2292.

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Nello svolgimento di questa tesi sperimentale sono state affrontate alcune problematiche analitiche relative alla caratterizzazione di leganti proteici in campioni provenienti da dipinti murali quali, la presenza di miscele complesse e degradate, le interferenze dovute alla presenza di specie inorganiche, le piccole dimensioni dei campioni, il rischio di contaminazione. La procedura pre-analitica ha previsto la determinazione della composizione amminoacidica mediante estrazione, purificazione, idrolisi e derivatizzazione del campione al fine di caratterizzarlo sfruttando le potenzialità analit

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19

Wang, Lanquing. "Characterization of selenide drugs and their metabolites by hydride generation ICP-MS and HPLC/ICP-MS." Diss., Georgia Institute of Technology, 1995. http://hdl.handle.net/1853/28041.

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20

Umbach, Frank [Verfasser]. "Stabilitäts- und Metabolismusuntersuchungen neuer purinerger Wirkstoffe und Ectonucleotidase-Inhibitoren mittels HPLC-DAD-MS(/MS) / Frank Umbach." Bonn : Universitäts- und Landesbibliothek Bonn, 2014. http://d-nb.info/1047622815/34.

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21

Tu, Travis Y. "HPLC and MS/MS Method for the Separation and Identification of Inositol Phosphates in C. Reinhardtii." Scholarship @ Claremont, 2016. http://scholarship.claremont.edu/cmc_theses/1306.

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Inositol phosphates (IPs) have important cellular functions from teleomere maintenance (IP7 and IP8) to Ca2+ signaling pathways (1, 4, 5-IP3). Yet there is no robust, quantitative method to separate all the inositol phosphate isomers from IP1 to IP8. Four findings contributed heavily towards the development of a robust, quantitative IP isomer separation and identification method on the EskpertTM MicroLC 200+ QTrap 6500 system with a SelexIonTM DMS attachment. 1) TCA from inositol phosphate algal extractions was removed by elution with 100 mM ammonium carbonate, ammonium formate, or ammonium bi

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22

Jungfer, Elvira [Verfasser]. "Authentizitätsbestimmung ausgewählter Vaccinium-Spezies mittels HPLC-MS / Elvira Jungfer." München : Verlag Dr. Hut, 2013. http://d-nb.info/1045988286/34.

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23

Zonaro, Victor Alexandre [UNESP]. "Análise de estirilpironas de Cryptocarya por HPLC-DAD-MS." Universidade Estadual Paulista (UNESP), 2016. http://hdl.handle.net/11449/147999.

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Submitted by Victor Alexandre Zonaro (victor.zonaro@gmail.com) on 2017-01-10T14:22:50Z No. of bitstreams: 1 Dissertação - Victor Alexadre Zonaro.pdf: 4719611 bytes, checksum: 075493217f07f41d58c2e71196b60eea (MD5)<br>Approved for entry into archive by LUIZA DE MENEZES ROMANETTO (luizamenezes@reitoria.unesp.br) on 2017-01-13T17:16:22Z (GMT) No. of bitstreams: 1 zonaro_va_me_araiq.pdf: 4719611 bytes, checksum: 075493217f07f41d58c2e71196b60eea (MD5)<br>Made available in DSpace on 2017-01-13T17:16:22Z (GMT). No. of bitstreams: 1 zonaro_va_me_araiq.pdf: 4719611 bytes, checksum: 075493217f07f41d

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Zonaro, Victor Alexandre. "Análise de estirilpironas de Cryptocarya por HPLC-DAD-MS /." Araraquara, 2016. http://hdl.handle.net/11449/147999.

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Orientador: Alberto José Cavalheiro<br>Banca: Cíntia Duarte de Freitas Milagre<br>Banca: Marcelo Telascrêa<br>Resumo: As 5,6-diidro-2-pironas 6-substituídas, também conhecidas como estirilpironas, são uma importante classe de metabólitos secundários presentes em plantas. São substâncias biologicamente ativas, apresentando como, por exemplo, atividade anticâncer, antioxidante, antifúngica e antiviral. O gênero Cryptocarya, pertence à família Lauraceae e apresenta diversas estirilpironas em suas mais diversas partes: folhas, cascas, sementes e raízes. Foram selecionadas para análise as espécies

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25

Jungfer, Elvira [Verfasser]. "Authentizitätbestimmung ausgewählter Vaccinium-Spezies mittels HPLC-MS / Elvira Jungfer." Bonn : Universitäts- und Landesbibliothek Bonn, 2013. http://d-nb.info/1045872040/34.

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26

Schuhmann, Imelda. "Aufbau einer HPLC-UV-ESI-MS-MS-Datenbank und ihre Anwendung im Screening arktischer und antarktischer Meeresbakterien." Doctoral thesis, [S.l.] : [s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=977037568.

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27

Egle, Hannes. "Schnelles und zuverlässiges therapeutisches Drug-Monitoring mit HPLC-UV und LC-LC, MS-MS aus komplexen Matrizes." [S.l.] : [s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=974035548.

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28

Hernández, Moreno Luis Gustavo Eduardo. "Implementación de una Metodología Analítica para la Cuantificación de Acrilamida en Papas Chips por HPLC MS/MS." Tesis, Universidad de Chile, 2007. http://www.repositorio.uchile.cl/handle/2250/105663.

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Memoria para optar al título de Químico Farmacéutico<br>En el año 2002 la Administración Nacional de Alimentos de Suecia detectó altas concentraciones de acrilamida que se formaba durante el calentamiento a altas temperaturas de alimentos ricos en almidón, como las papas fritas, pan, galletas, alimentos extruídos, etc. La acrilamida es genotóxico y ha sido clasificada como “probable carcinogénico para humanos” (Grupo 2A) por la Agencia Internacional de Investigación sobre Cáncer IARC, y esta exposición causa daño al sistema nervioso en seres humanos y animales Con motivo de este hallazgo

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Bandeira, Nelson Miguel Grubel. "Determinação multiclasse de resíduos de medicamentos veterinários em músculo ovino por HPLC-FD E UHPLC-MS/MS." Universidade Federal de Santa Maria, 2015. http://repositorio.ufsm.br/handle/1/10603.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico<br>The application of good livestock practices in the sheep industry is a growing concern on food security due to the increase of financial transactions in this sector in Brazil, mainly due to imports. To perform the monitoring Maximum Residue Limits (MRLs) are adopted such as suitable matrices for monitoring. The deposition of residues of veterinary drugs in sheep muscle is verified by appropriate analytical methods. In this work it were developed two methods aiming to determine avermectins residues in ovine muscle by HPLC-FD using

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Samson-Thibault, François. "Analyse des modifications de la cytosine après oxydation de l'ADN par digestion enzymatique et HPLC-MS/MS." Mémoire, Université de Sherbrooke, 2012. http://hdl.handle.net/11143/6359.

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Résumé: Les dommages à la cytosine, spontanés et induits par des oxydants, sont probablement la principale cause des transitions GC vers AT, la mutation du génome la plus commune chez les organismes aérobiques. Ces dommages sont impliqués dans le processus de mutagenèse, dans le vieillissement et dans le cancer. Les dommages à la cytosine par les oxydants et les radicaux libres sont nombreux et ont été découverts et étudiés dans les monomères de cytosines et dans de courts oligonucléotides. Dans cette étude, nous avons développé une méthode d'analyse par HPLC-MS/MS des plus importants produits

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31

Schütze, Gregor. "Entwicklung, Validierung und Anwendung einer HPLC-MS/MS-Methode zur quantitativen Bestimmung von Tryptophan und seinen Metaboliten." Diss., Ludwig-Maximilians-Universität München, 2014. http://nbn-resolving.de/urn:nbn:de:bvb:19-175326.

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Die vorliegende Arbeit beschäftigt sich mit der Entwicklung, Validierung und Anwendung einer HPLC-MS/MS-Methode zur quantitativen Bestimmung von Tryptophan und seinen Metaboliten. Der Stoffwechsel der proteinogenen, essentiellen Aminosäure Tryptophan umfasst nicht nur den Neurotransmitter Serotonin und das in der Epiphyse gebildete Hormon Melatonin, sondern er schließt auch den Kynurenin Pathway mit ein. Die neurobiochemische Bedeutung dieses Stoffwechselweges wird bereits durch die Tatsache offensichtlich, dass im zentralen Nervensystem mehr als 95% des Tryptophans über diesen Weg metabolisie

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Myers, Tanya R. "New Techniques for the Qualitative and Quantitative Measurement of Naturally-Ocurring Gonadotropin-Releasing Hormone Analogues by Mass Spectrometry." Digital Archive @ GSU, 2007. http://digitalarchive.gsu.edu/chemistry_diss/12.

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GnRH peptides have been discovered in a wide variety of vertebrate and invertebrate organisms, and work is ongoing to characterize additional unique isoforms. This dissertation describes the investigation of reversed-phase chromatographic and mass spectrometric behavior of GnRH peptides, the development and application of an LC-MS/MS method for qualitative identification of GnRH peptides, and the comprehensive validation of an LC-MS/MS method for simultaneous, quantitative measurement of hydroxyproline9GnRH (Hyp9GnRH) and mammalian GnRH (mGnRH) in rat brain tissues. Chromatographic and mass s

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Armando, Yara Popst. "Avaliação da bioequivalência entre comprimido convencional e comprimido de desintegração oral contendo 8 mg de ondansetrona." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/9/9139/tde-08102009-190008/.

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A ondansetrona (1,2,3,9-tetrahidro-9-metil-3-[(2-metil-1H-imidazol-1-il)metil]-4H-carbazol-ona) é o primeiro fármaco da classe dos antagonistas seletivos dos receptores de serotonina 5-HT3. É utilizada na prevenção de náusea e vômito induzidos por agentes quimioterápicos. O objetivo deste estudo foi avaliar a equivalência terapêutica através da análise da bioequivalência de dois produtos contendo 8 mg de ondansetrona, sendo um sob a forma de comprimidos de liberação convencional e outro sob a forma de comprimidos de desintegração oral, produzidos por laboratórios distintos. O ensaio de bioequi

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Brioschi, Tatiane Maria de Lima Souza. "Avaliação da bioequivalência de comprimidos contendo 10 mg de cloridrato de ciclobenzaprina." Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/9/9139/tde-13122006-091912/.

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A ciclobenzaprina é um relaxante muscular de ação central estruturalmente similar aos antidepressivos tricíclicos. O objetivo deste trabalho foi avaliar a bioequivalência de comprimidos contendo 10 mg de cloridrato de ciclobenzaprina em voluntários sadios. O estudo de bioequivalência entre o produto teste (Miosan®) e referência (Flexeril®) foi do tipo randomizado, aberto e cruzado. Os produtos foram administrados por via oral aos voluntários em dose única de 10 mg de cloridrato de ciclobenzaprina. Amostras de sangue foram coletadas até 240 horas após a administração do fármaco e quantifica

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35

Mataveli, Lidiane Raquel Verola 1983. "Metalômica comparativa de soja [Glycine max (L.) Merrill] transgênica e não-transgênica utilizando sistema multidimensional de separação." [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/248607.

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Orientadores: Marco Aurélio Zezzi Arruda, Ljubica Tasic<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Química<br>Made available in DSpace on 2018-08-23T02:17:28Z (GMT). No. of bitstreams: 1 Mataveli_LidianeRaquelVerola_D.pdf: 1935019 bytes, checksum: 059066ee53b01850e2858460ba23617e (MD5) Previous issue date: 2013<br>Resumo: Este trabalho consistiu em estudos de metalômica comparativa de sementes de soja transgênica (T) e não-transgênica (NT). Para tanto, as sementes de soja T e NT foram comparadas, em um primeiro, momento levando-se em conta: concentração total dos e

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Nascimento, DemÃtrius Fernandes do. "Nimodipine determination in human plasma by high-performance liquid chromatography coupled to tandem mass spectrometry (HPLC-MS-MS)." Universidade Federal do CearÃ, 2005. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=31.

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Conselho Nacional de Desenvolvimento CientÃfico e TecnolÃgico<br>A rapid, specific and highly sensitive liquid chromatography-tandem mass spectrometry method was developed to determine nimodipine in human plasma using dibucaine as the internal standard (IS) is described. The analyte (m/z 418,6 > 342,6) and IS (m/z 344,2 > 271,0) were extracted from plasma samples by liquid-liquid extraction using hexane-ethyl acetate (1:1v/v). Chromatography was performed on a VarianÂ Polaris C18 analytical column (3 micrometer, 50 x 2,0 mm) and pre-column SecurityguardTM C18 (4,0 x 3,0 mm). The phase mobile c

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Jones, Owen G. "Comparison of analytical techniques for quantification of 8-iso-PGF2[alpha] using HPLC-MS-MS and enzyme immunoassay." Connect to this title online, 2005. http://hdl.handle.net/1811/347.

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Thesis (Honors)--Ohio State University, 2005<br>Title from first page of PDF file. Document formattted into pages: contains, 16 p.; also includes graphics. Includes bibliographical references (p. 15-16) Available online via Ohio State University's Knowledge Bank.

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Persson, Josefin. "Development and evaluation of methods for analysis of TBECH and HBCD using HRGC/HRMS and HPLC/MS/MS." Thesis, Örebro University, School of Science and Technology, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-7695.

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<p>The two additive brominated flame retardants, tetrabromoethylcyclohexane (TBECH) and hexabromocyclododecane (HBCD) are used to prevent fire to start and spread. They are simply mixed with material and are most likely to leach out in the environment, because of non-covalently binding to the material. TBECH can exist as four pairs of enantiomers, α-, β-, γ- and δ-TBECH. The technical HBCD can exist as three pairs of enantiomers, α-, β- and γ-HBCD and two meso forms δ- and ε-HBCD. None of these compounds are produced in Sweden, but they are imported to industries. TBECH has been found in Belug

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Silva, Elidiane Gomes da 1983. "Combinação de técnicas para a determinação de espécies de selênio." [s.n.], 2012. http://repositorio.unicamp.br/jspui/handle/REPOSIP/248605.

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Orientadores: Marco Aurélio Zezzi Arruda, Fábio Augusto<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Química<br>Made available in DSpace on 2018-08-21T15:26:25Z (GMT). No. of bitstreams: 1 Silva_ElidianeGomesda_D.pdf: 2153115 bytes, checksum: 5169aef7da6fd6ddcc74f0fd71a98fe7 (MD5) Previous issue date: 2012<br>Resumo: No Capítulo 1, é proposta a combinação das técnicas de microextração em fase sólida com a espectrometria de absorção atômica em forno de grafite para extração de Se(IV) derivado, seguida de detecção por GC-MS. O método é aplicado com sucesso na determina

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Rivas-Urraca, Cristina. "Environmental speciation of tin and lead by HPLC-ICP-MS." Thesis, University of Plymouth, 1996. http://hdl.handle.net/10026.1/459.

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New methodologies have been developed for the determination of organotin and organolead compounds in environmental samples. Several high performance liquid chromatographic separations of organotin compounds have been tested and the best system (cation-exchange chromatography with methanol and a citrate buffer) employed for the determination of tributyltin (TBT), triphenyltin (TPhT), dibutyltin (DBT) and monobutyltin (MBT) in environmental samples. The coupling between high performance liquid chromatography (HPLQ and the inductively coupled plasma-mass spectrometer (ICP-MS) for this application

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Ghebreamlak, Weyni. "Identification of Trypsin Digested Transferrin using HPLC and MALDI-MS." Thesis, KTH, Skolan för kemi, bioteknologi och hälsa (CBH), 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-266157.

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In this project, separation of trypsin digested transferrin (Tf) has been studied, using a RP HPLC- UV system equipped with a C18 column. 0.1% TFA/MQ-water and 90% MeOH were used as mobile phase A and mobile phase B, respectively. For economic reasons, the protein cytochrome c (cyt-C) was used to optimize the digestion procedure and LC system, before analysis of Tf. Four digestion methods were applied for analyzing cyt-C and Tf. The first method was digestion with no denaturing, reducing or alkylating agent. The other digestion methods used urea or heating as a denaturing agent, and lastly dit

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Rösemann, G. M. "Analysis of pyrrolizidine alkaloids in Crotalaria species by HPLC-MS/MS in order to evaluate related food health risks." Electronic thesis, 2006. http://upetd.up.ac.za/thesis/available/etd-08032007-170633/.

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Lorenzetti, Raquel. "Metodo de quantificação de nucleotideos por HPLC-MS/MS e avaliação da atividade de analogos de sildenafil sobre fosfodiesterase." [s.n.], 2007. http://repositorio.unicamp.br/jspui/handle/REPOSIP/309493.

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Orientador: Gilberto de Nucci<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas<br>Made available in DSpace on 2018-08-10T06:11:56Z (GMT). No. of bitstreams: 1 Lorenzetti_Raquel_D.pdf: 2089930 bytes, checksum: f6ed8b98e678ffdfc6051c645efc8b4b (MD5) Previous issue date: 2007<br>Resumo: No presente trabalho foi padronizado um novo método para a dosagem da atividade de fosfodiesterase in vitro, por HPLC-MS/MS. Este novo método conseguiu apresentar exatidão, precisão, sensibilidade e rapidez nas análises; monitorando os nucleotídeos (AMP, GMP, AMPc e GMPc). O

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Rosemann, G. M. (Gertruida Magdalena). "Analysis of pyrrolizidine alkaloids in Crotalaria species by HPLC-MS/MS in order to evaluate related food health risks." Thesis, University of Pretoria, 2007. http://hdl.handle.net/2263/26960.

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Pyrrolizidine alkaloids (PAs) are one of the most significant groups of plant toxins in the world and are an important cause of poisoning in livestock, resulting in significant financial and production losses each year (Kellerman et al. 1996). Pyrrolizidine alkaloids may also enter the human food chain as contaminants of grains, via animal products such as milk, eggs and honey or may be consumed as constituents of herbal medicines (ANZFA 2001). Not all PAs are toxic. Pyrrolizidine alkaloids affecting human health are the esters of 1,2-unsaturated hydroxymethyl dehydropyrrolizidines (DHP). Befo

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Dubber, Mary-Jean. "Application of CE, HPLC and LC-MS-MS for the analysis and quality control of Ginkgo biloba dosage forms." Thesis, Rhodes University, 2006. http://hdl.handle.net/10962/d1003235.

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Natural products are complex mixtures of compounds with therapeutic effects which are often reported to be due to the synergistic action of multiple and sometimes unknown components. Consequently, standardization of these products is complex and a lack of effective quality control (QC) criteria in most countries has led to marketing of commercial products with questionable quality, safety and efficacy (QSE). The aim of this study was therefore to develop qualitative and quantitative analytical methods for use in the QC of Ginkgo biloba solid oral dosage forms. Initially, a micellar electrokine

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Borsò, Marco. "HPLC-MS-MS analysis of thyroid hormones and iodotyrosines in knocked-out murine and natural human DEHAL-1 deficiency." Doctoral thesis, Università di Siena, 2021. http://hdl.handle.net/11365/1128063.

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Thyroid hormones (TH), namely 3,5,3’-triiodothyronine (T3) and its precursor thyroxine (T4), are key regulators of growth processes and development, and crucially control the energy metabolism. A proper availability of iodine within the thyroid is crucial for the synthesis of TH in order to maintain the homeostasis of circulating levels. The daily dietary iodine intake is not sufficient to sustain their synthesis and, in fact, most of the intra-thyroidal iodine is recycled through the activity of the Iodotyrosine Dehalogenase-1 (DEHAL-1) enzyme. Mono-iodotyrosine (MIT) and di-iodotyrosine (DIT

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Aguiar, Giovanna de Fatima Moreno. "Avaliação de métodos empregando a espectrometria de massas com plasma acoplado (ICP-MS) para determinação de impurezas elementares e especiação química de arsênio e mercúrio em fármacos e excipientes." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/60/60134/tde-23112017-113653/.

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Com o aumento das exigências regulatórias e estabelecimento de limites mais restritos para impurezas elementares em fármacos e excipientes usados em formulações farmacêuticas, ocorreu uma busca por técnicas analíticas capazes de quantificar elementos em níveis traço e assegurar a qualidade e a segurança dos medicamentos. A espectrometria de massas com plasma acoplado indutivamente (ICP-MS) é uma técnica multielementar, que apresenta alta sensibilidade e é empregada com eficiência na análise de elementos traço em diferentes matrizes. O ICP-MS, acoplado a um sistema separador como o cromatógrafo

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Wohlfarth, Michael. "Die Aufklärung der Biogenese strukturell ungewöhnlicher Alkaloide aus Triphyophyllum (Dioncophyllaceae) und Antidesma (Euphorbiaceae) und Entwicklung und Einsatz der "Triade" zur phytochemischen Online-Analytik: HPLC-MS-MS, HPLC-NMR und HPLC-CD." [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=969623372.

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LEITE, J. A. "Estudo do Perfil Químico de Apreensões de Maconha por RMN de 1H e Outras Técnicas Analíticas." Universidade Federal do Espírito Santo, 2017. http://repositorio.ufes.br/handle/10/7321.

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Made available in DSpace on 2018-08-01T21:36:54Z (GMT). No. of bitstreams: 1 tese_10767_Dissertação Corrigida - Versão Final - Júlia de Almeida Leite.pdf: 16379069 bytes, checksum: f5cdfd44e4f8ccf3e78d9c10b90dc473 (MD5) Previous issue date: 2017-03-30<br>A maconha é a droga ilícita mais consumida no mundo. Ela é derivada da planta Cannabis sativa L. Neste trabalho, um total de 156 amostras de maconha apreendidas no estado do Espírito Santo (ES) Brasil foram estudadas e analisadas por RMN de 1H a fim de se identificar seus principais canabinoides. Primeiramente, para se otimizar a identifica

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Meiby, Elinor, Zetterberg Malin Morin, Sten Ohlson, Hernández Víctor Agmo, and Katarina Edwards. "Immobilized lipodisks as model membranes in high-throughput HPLC-MS analysis." Uppsala universitet, Analytisk kemi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-197337.

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Lipodisks, also referred to as polyethylene glycol (PEG)-stabilized bilayer disks, have previously been demonstrated to hold great potential as model membranes in drug partition studies. In this study, an HPLC-MS system with stably immobilized lipodisks is presented. Functionalized lipodisks were immobilized on two different HPLC support materials either covalently by reductive amination or by streptavidin-biotin binding. An analytical HPLC column with immobilized lipodisks was evaluated by analysis of mixtures containing 15 different drug compounds. The efficiency, reproducibility, and stabil

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