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Journal articles on the topic 'HPMC (15 cps)'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

K., Rekha Rani* Y. Navya Reddy R. Mohana Priya. "FORMULATION AND EVALUATION OF SUSTAINED RELEASE DOSAGE FORM OF KETOPROFEN." indo American Journal of Pharmaceutical Sciences 04, no. 05 (2017): 1384–90. https://doi.org/10.5281/zenodo.804916.

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Sustained release Ketoprofen matrix tablets were prepared by direct compression method. The nature of the polymer influences the physical and release characteristics of the matrix tablet. The hydrophobic polymer, Ethyl cellulose has retarded the drug release from the tablet and the hydrophilic polymer, HPMC (15 cps) has release the drug. While making the combination of both hydrophilic and hydrophobic polymers i.e HPMC and Ethylcellulose with optimized ratio (F7) leads to sustained release of drug from matrix tablet for 12 hours was observed Key words: Ketoprofen, HPMC (15 cps), Ethyl cellulos

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2

Islam, Md Saiful, Md Ziaur Rahman Khan, Masuda Khatun, Jakir Ahmed Chowdhury, and Md Selim Reza. "Studies on Bio-adhesion of Matrix Tablets: II.Comparison on Bio-adhesion Strength and Release Profiles of Theophylline Anhydrous and Its Sodium Glycinate Salt." Dhaka University Journal of Pharmaceutical Sciences 10, no. 1 (2012): 1–7. http://dx.doi.org/10.3329/dujps.v10i1.10008.

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Controlled release matrix tablets of Theophylline anhydrous and Theophylline sodium glycinate were prepared with different types of bio-adhesive polymers e.g. HPMC 15 & 50 cps, Gelatin, PVP K-30, Na-CMC and Xanthan gum. Tablets, prepared by direct compression method were subjected to in-vitro drug dissolution for 8 hours in 0.1 N hydrochloric acid (pH 1.2) using a thermal shaker at 50 rpm at 37 ± 0.5ºC. The bio-adhesive property was investigated in terms of retention time following in-vitro wash-off method by Lehr et al. The anhydrous and corresponding salt form was used to investigate whe

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3

Akhila, Salla, and Dr U. Mohan Kumar. "Formulation and evaluation of a pH induced in situ occular gelling system of piroxicam." International Journal of Clinical Pharmacokinetics and Medical Sciences 5, no. 3 (2025): 21–29. https://doi.org/10.26452/ijcpms.v5i3.778.

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Poor ocular bioavailability is caused by the traditional liquid ophthalmic delivery systems' short pre-corneal residence time and relative corneal impermeability. Based on the concept of pH-induced in situ gelation, the current study aimed to develop and evaluate an ocular delivery system for the non-steroidal anti-inflammatory medication Piroxicam. Sodium alginate was used as the gelling agent in combination with HPMC (0.25-0.75% w/v), which acted as a viscosity-enhancing agent. Compatibility studies of the drug excipients were carried out using FTIR studies. Clearness, pH, gelation studies,

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4

Nadimpalli, Naga Anusha, and Sunitha Reddy, M. "Formulation and Evaluation of Olmesartan Medoxomil Transdermal Drug Delivery System." Saudi Journal of Medical and Pharmaceutical Sciences 8, no. 10 (2022): 518–26. http://dx.doi.org/10.36348/sjmps.2022.v08i10.005.

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Transdermal patches are cutting-edge drug delivery methods that are essential to the management of many diseases. Due to the avoidance of first pass metabolism the drug molecules are delivered into the systemic circulation at a controlled and predefined pace with the help of TDDS, which also helps to achieve efficient bioavailability. This study's goal was to create matrix-type Olmesartan medoxomil transdermal patches utilizing the solvent evaporation method and various polymer ratios, including HPMC 15 cps, HPMC 5 cps, and Eudragit S 100. Plasticizers like glycerin, propylene glycol, and PEG

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KODI SHRUTI and M. SUNITHA REDDY. "Preparation and characterization of quetiapine fumarate loaded transfersome as a novel drug delivery system." GSC Biological and Pharmaceutical Sciences 25, no. 2 (2023): 372–86. http://dx.doi.org/10.30574/gscbps.2023.25.2.0463.

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Modern medicine delivery techniques like transdermal patches are vital for treating numerous disorders. With the aid of TDDS, first pass metabolism is prevented, which aids in achieving effective bioavailability. Drug molecules are also released into the systemic circulation at a controlled and predetermined rate. The objective of this study was creating matrix-type Quetiapine fumarate loaded transdermal patches with water bath method using different polymers like HPMC 5 cps, HPMC 15 cps, and Ethyl cellulose in different ratios. Polyethylene glycol-400, Dimethyl sulfoxide (DMSO) as a plasticiz

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KODI, SHRUTI, and SUNITHA REDDY M. "Preparation and characterization of quetiapine fumarate loaded transfersome as a novel drug delivery system." GSC Biological and Pharmaceutical Sciences 25, no. 2 (2023): 372–86. https://doi.org/10.5281/zenodo.10610028.

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Modern medicine delivery techniques like transdermal patches are vital for treating numerous disorders. With the aid of TDDS, first pass metabolism is prevented, which aids in achieving effective bioavailability. Drug molecules are also released into the systemic circulation at a controlled and predetermined rate. The objective of this study was creating matrix-type Quetiapine fumarate loaded transdermal patches with water bath method using different polymers like HPMC 5 cps, HPMC 15 cps, and Ethyl cellulose in different ratios. Polyethylene glycol-400, Dimethyl sulfoxide (DMSO) as a plasticiz

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7

M., Shobana. "Formulation and Evaluation of Fast Dissolving Oral Films of Sitagliptin Phosphate by Solvent Casting Method." International Journal of Pharmacy and Biological Sciences (IJPBS) 13, no. 3 (2023): 106–15. https://doi.org/10.5281/zenodo.10430292.

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Abstract The aim of this research work was to formulate fast-dissolving oral films of sitagliptin phosphate for the treatment of diabetes mellitus. The fast dissolving films of sitagliptin phosphate were prepared by solvent casting method using film forming polymers HPMC E 15 and HPMC E 50 cps and PEG and propylene glycol are used as plasticizers. All the films prepared were evaluated for weight variation, thickness, folding endurance, percentage elongation, tensile strength, drug content, <em>In</em>-vitro disintegration time, in-vitro dissolution test, SEM analysis and stability studies. All

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8

Edityaningrum, Citra Ariani, Artika Tri Oktafiani, Lina Widiyastuti, and Dewa Ayu Arimurni. "Formulation and Evaluation of Silver Nanoparticles Gel." Indonesian Journal of Pharmaceutical Science and Technology 9, no. 2 (2022): 125. http://dx.doi.org/10.24198/ijpst.v9i2.35343.

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Silver nanoparticles are known to be able to penetrate the cell membranes of acne-causing bacteria andcause structural damages that result in bacterial cell death. Silver nanoparticles need to be formulated inthe form of a gel to make it easier to use. This study was conducted to synthesis the silver nanoparticlesand to formulate it in the form of gel. The synthesis of silver nanoparticles was carried out usingthe chemical reduction method with sodium citrate as a reducing agent and gelatin as a stabilizersolution. The characterization results of silver nanoparticles obtained a maximum wavelen

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9

Ananthu, Likhitha, and Anie Vijetha, K. "Formulation and Evaluation of Simvastatin Transdermal Drug Delivery System." Saudi Journal of Medical and Pharmaceutical Sciences 8, no. 10 (2022): 527–35. http://dx.doi.org/10.36348/sjmps.2022.v08i10.006.

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Transdermal patches are a cutting-edge drug delivery technology that is essential in the management of many disorders. As first-pass metabolism is avoided, TDDS can effectively increase bioavailability and aid in the delivery of drug molecules into the systemic circulation at a planned and controlled rate. This study's goal was to create matrix-type simvastatin transdermal patches utilising the solvent evaporation method and various polymer ratios, including HPMC 15 cps, HPMC E5, and Eudragit S 100. Plasticizers like glycerine, propylene glycol, and PEG 200 are utilised, along with solvents li

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10

Patil, Swapnil, Manojkumar M. Nitalikar, and Preeti Khulbe. "Design and Development of Nanoparticle Based Nanogel Formulation of Bixa Orellena Seed Extract." International Journal of Pharmaceutical Sciences and Nanotechnology(IJPSN) 18, no. 1 (2025): 7842–48. https://doi.org/10.37285/ijpsn.2025.18.1.11.

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Background: Bixa orellana is known to contain Bixin, which has been known for its antifungal, antibacterial, and anti-inflammatory properties. Topical drug delivery is a widely utilized approach for achieving defined and sustained release of drugs at the intended site of action. Objective: The goal of the study is to prepare a nanoparticle based nanogel formulation from Bixa orellana seed extract. The present research work involves the synthesis of silver nanoparticles using an environmentally harmless and economically efficient method, utilizing the extract obtained from the seeds of Bixa ore

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11

Rajini, Kanth Giddam, and AnieVijetha K. "Formulation and evaluation of Ketorolac tromethamine for transdermal drug delivery system." GSC Biological and Pharmaceutical Sciences 22, no. 3 (2023): 153–62. https://doi.org/10.5281/zenodo.7920067.

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Nonsteroidal anti-inflammatory drugs (NSAIDs) such as Ketorolac Tromethamine are widely recommended to treat pain caused by osteoarthritis, ankylosing spondylitis, acute sciatica, rheumatoid arthritis and low back pain. Modern drug delivery technology, such as transdermal patches, is mostly used in the treatment of numerous diseases. As first-pass metabolism is avoided. Transdermal drug delivery systems (TDDS) can efficiently enhance bioavailability and help with the planned and controlled release of drug molecules into the systemic circulation. The purpose of this work was to produce matrix-t

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12

Rajini Kanth Giddam and K AnieVijetha. "Formulation and evaluation of Ketorolac tromethamine for transdermal drug delivery system." GSC Biological and Pharmaceutical Sciences 22, no. 3 (2023): 153–62. http://dx.doi.org/10.30574/gscbps.2023.22.3.0085.

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Nonsteroidal anti-inflammatory drugs (NSAIDs) such as Ketorolac Tromethamine are widely recommended to treat pain caused by osteoarthritis, ankylosing spondylitis, acute sciatica, rheumatoid arthritis and low back pain. Modern drug delivery technology, such as transdermal patches, is mostly used in the treatment of numerous diseases. As first-pass metabolism is avoided. Transdermal drug delivery systems (TDDS) can efficiently enhance bioavailability and help with the planned and controlled release of drug molecules into the systemic circulation. The purpose of this work was to produce matrix-t

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13

Pebriani, Ajeng Ayu, and Maya Uzia Beandrade. "FORMULATION AND EVALUATION OF GEL MASK PEEL OF BLACK GLUTINOUS RICE EXTRACT (ORYZA SATIVA VAR GLUTINOSA) AND GREEN TEA (CAMELIA SINENSIS)." Jurnal Mitra Kesehatan 4, IAHSC (2021): 1–11. http://dx.doi.org/10.47522/jmk.v1iiahsc.106.

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Introduction: Black glutinous rice (Oriza sativa var glutinosa) and green tea (Camelia sinensis) are plants that are useful for moisturizing the skin. The purpose of this study was to obtain the best formulation of peel-off gel mask preparations from black glutinous rice and green tea extract. Method: The gel mask formulation was made on the basis of variations in the concentration of Hydroxy Propyl Methyl Cellulose (HPMC) of F1 (2,5%), F2 (3%) and F3 (3,5%) with evaluation including organoleptic tests, pH, viscosity, homogenity, dispersity test, and drying time at temperatures of 4oC, 25oC, 4

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14

Rao, Pingali Srinivasa, and T. Rama Mohan Reddy. "Formulation, Optimization and Evaluation of Rasagiline Mouth Dissolving Films." International Journal of Pharmaceutical Sciences and Nanotechnology 11, no. 6 (2018): 4323–31. http://dx.doi.org/10.37285/ijpsn.2018.11.6.5.

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The oral route is the most preferred route, though preoral administration of drug has disadvantage like hepatic first pass metabolism and enzymatic degradation within the GI tract. Trans-mucosal routes of drug delivery offer distinct advantage over preoral administration. The aim of present investigation was to formulate the fast-dissolving oral films (FDOF) of rasagiline, an anti-Parkinson drug. In the present study, rasagiline fast dissolving films were formulated by solvent-casting method containing HPMC 5cps, 15 cps and 50 cps as polymers and PEG 400 as plasticizer, Crospovidone and SSG as

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15

Islam, Muhammad Rashedul, Md Mizanur Rahman Moghal, FM Shah Noman Ul Bari, and Elias Al Mamun. "Design and Development of Bi-layered Sustained Release Azithromycin Tablets." Dhaka University Journal of Pharmaceutical Sciences 15, no. 2 (2017): 227–34. http://dx.doi.org/10.3329/dujps.v15i2.30942.

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The objective of the current study was to develop a bilayer tablet of Azithromycin containing both immediate and sustained layer and evaluate the effect of formulation variables on drug release. Thirty different formulations (F-1 to F-30) were prepared by direct compression. When the fraction of polymer was increased from 5.55% to 10%, the rate of drug release was found to be slower. Maximum release of Azithromycin was from F-11 (within 8 hours), which contained 50 mg (5.55%) of HPMC 50 cps. Slowest release was observed from F-30 containing 90 mg (10%) of Carbopol 974 P. The IR spectral analys

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16

Sukmawati and Elsa Yuliani. "Formulasi Dan Evaluasi Sediaan Gel Tabir Surya Dari Serbuk Cangkang Telur Ayam Ras (Gallus Gallus) Dengan Variasi Basis Gel Carbopol 940 Dan HPMC." Jurnal Medika Farmaka 1, no. 2 (2023): 88–94. https://doi.org/10.33482/jmedfarm.v1i2.9.

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Pendahuluan: Cangkang telur ayam ras (Gallus gallus) merupakan salah satu limbah yang mempunyai kandungan senyawa aktif kalsium terutama senyawa kalsium karbonat yang memiliki mekanisme kerja physical blocker pada tabir surya dengan memantulkan radiasi UV untuk membentuk lapisan buram dipermukaan kulit. Metode: Metode penelitian ini eksperimental di Laboratorium dengan membuat 4 formula gel tabir surya dari serbuk cangkang telur ayam ras dengan kosnentrasi 15% yang terdiri F0 tanpa basis , F1 Carbopol 940 0,5 % dan HPMC 1%, F2 Carbopol 940 0,75% dan HPMC 0,75%, F3 Carbopol 940 1% dan HPMC 0,5%

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17

Islam, Muhammad Rashedul, Md Elias Al Mamun, Md Mizanur Rahman Moghal, and Md Habibur Rahman. "Development and Evaluation of Indomethacin Controlled Release Press Coated Tablets." Dhaka University Journal of Pharmaceutical Sciences 14, no. 2 (2016): 187–92. http://dx.doi.org/10.3329/dujps.v14i2.28509.

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In the present work, several batches of indomethacin press coated tablets were prepared with drug and Avicel PH 102 utilizing the press coating technology. The core tablet was compression coated with minimal compression pressure. The compression coating mixture was formulated using various amount of lactose and xanthan gum which was used as the release retarding agent. Three formulations (IX-1, IX-2 and IX-3) were designed to evaluate the release profile as function of xanthan gum load. In vitro drug release testing demonstrated that the drug release was inversely proportional to the amount of

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18

Husni, Patihul, Adi Prayitno, Ardian Baitariza, Mikhania Christiningtyas Eryani, and Melinda Januarti. "Pengembangan Sediaan Gel Ekstrak Bonggol Pisang Ambon." JURNAL FARMASI GALENIKA 12, no. 1 (2025): 41–56. https://doi.org/10.70410/jfg.v12i1.382.

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Pisang Ambon (Musa paradisiaca var. sapientum (L.)) mempunyai bonggol dengan banyak manfaat diantaranya untuk penyembuhan luka. Bonggol pisang Ambon mengandung protein, lemak, vitamin A dan C. Selain itu, tannin, flavonoid, dan saponin yang terkandung dalam getah bonggol pisang Ambon bermanfaat dalam penyembuhan luka. Adapun tujuan studi ini ialah untuk mendapatkan formula terbaik gel mengandung ekstrak bonggol pisang Ambon berdasarkan evaluasi fisik. Penelitian dilakukan dengan membuat tiga formulasi gel yang berbeda (F1, F2, F3) mengandung ekstrak bonggol pisang ambon 5%. Evaluasi fisik sedi

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19

Reddy, Neralapalli Nikitha, and Shaik Muhammad Fazal ul Haq. "Formulation and Evaluation of Hydrogel Based Oral Controlled Drug Delivery System for Saquinavir." Saudi Journal of Medical and Pharmaceutical Sciences 8, no. 10 (2022): 575–84. http://dx.doi.org/10.36348/sjmps.2022.v08i10.011.

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The main aim of this study was to develop hydrogel based controlled drug delivery system of Saquinavir mesylate as hard gelatin capsule which are able to deliver the drug at prolonged rate. The hydrogel was prepared by crosslinking HPMC 15 cps and Carbopol 971P and then granules are developed using MCC as diluent. Drug excipient compatibility was studied by FT-IR. The prepared hydrogels formulation are evaluated for Swelling index. Drug release from hydrogel was performed by using Franz diffusion cell. The prepared granules are evaluated for pre formulation studies (Bulk density, Tapped densit

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20

KHANDARE, BALU S., and Komal S. Wagh. "Formulation, Development and Evaluation of Fast Dissolving Oral Film of a Atenolol Drug and validation by RP-HPLC Method using ICH Q2 guidelines." Journal of Drug Delivery and Therapeutics 9, no. 5 (2019): 99–104. http://dx.doi.org/10.22270/jddt.v9i5.3582.

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Now a days, fast dissolving dosage forms are gaining popularity, as this dosage form can be administered without water. Rapid dissolving property, avoiding first pass metabolism and majority of the drug is absorbed through buccal/oral mucosa in to systemic circulation. On oral administration of atenolol undergoes first pass metabolism results in reduced bioavailability up to (60%), so the objective of the present study was to formulate and evaluate fast dissolving oral films of atenolol to overcome the limitation of bioavailability and increase patient’s compliance. In recent studies oral film

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21

Sandhyarani, G., and M. Madhuri. "DEVELOPMENT & EVALUATION OF FAST DISINTEGRATING FILMS AND TABLETS OF VALSARTAN." International Journal of Medical Sciences and Pharma Research 4, no. 1 (2018): 17–28. http://dx.doi.org/10.22270/ijmspr.v4i1.23.

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Orodispersible dosage forms are used for accurate dosing, enhanced bioavailability, rapid action, patient compliance, easy of administration, enhanced palatability. Valsartan is a specific and selective type-1 angiotensin II receptor antagonist which blocks the blood pressure increasing effects angiotensin II via the renin-angiotensin-aldosterone system. Valsaratan orodispersible films are prepared using all polymers HPMC E3,HPMC E15,HPMC 5cps,HPMC 15cps,HPMC 50cps, HPMC 50cps+CP in 39.68 mg., 59.52 mg quantity with different formulations with citric acid as disintegrating agent. Valsartan oro

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22

Buček, Jan, Marek Zatloukal, Libor Havlíček, et al. "Total synthesis of [ 15 N]-labelled C6-substituted purines from [ 15 N]-formamide—easy preparation of isotopically labelled cytokinins and derivatives." Royal Society Open Science 5, no. 11 (2018): 181322. http://dx.doi.org/10.1098/rsos.181322.

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Cytokinins (CKs) and their metabolites and derivatives are essential for cell division, plant growth regulation and development. They are typically found at minute concentrations in plant tissues containing very complicated biological matrices. Therefore, defined standards labelled with stable isotopes are required for precise metabolic profiling and quantification of CKs, as well as in vivo elucidation of CK biosynthesis in various plant species. In this work, 11 [ 15 N]-labelled C6-purine derivatives were prepared, among them 5 aromatic ( 4, 5, 6, 7, 8 ) and 3 isoprenoid ( 9, 10, 11 ) CKs. C

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23

Davydova, I. O., O. A. Ruban, H. D. Slipchenko, I. V. Zupanets, and O. I. Ivaniuk. "Substantiation of the composition of sublingual tablets for the treatment of CNS disorders." News of Pharmacy 108, no. 2 (2024): 37–42. http://dx.doi.org/10.24959/nphj.24.145.

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Aim. To develop the composition of sublingual tablets with L-tryptophan, glycine and a dry peony extract. Materials and methods. L-tryptophan, glycine and a dry peony extract were used as active pharmaceutical ingredients; Lactose GranuLac 200, MCC 102, HPMC methocel K4M CR Premium, HPMC methocel E4M CR Premium, aspartame, maltodextrin, sorbitol, sucralose, Mint cloroph FLV PDR, Strawberry FLV PDR, Apple FLV PDR, Plasdone K-25, crospovidone XL-10, nonessylin and calcium stearate were used as excipients. The pharmacotechnological studies were conducted in accordance with the methods of the Stat

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Drzymala, S., J. Riedel, R. Köppen, L. A. Garbe, and M. Koch. "Preparation of 13C-labelled cis-zearalenone and its application as internal standard in stable isotope dilution analysis." World Mycotoxin Journal 7, no. 1 (2014): 45–52. http://dx.doi.org/10.3920/wmj2013.1610.

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Pure U-[13C18]-labelled cis-zearalenone (cis-ZEA) has been prepared and characterised as internal standard (ISTD) for a reliable quantification of cis-ZEA in contaminated food and feed products. The cis-isomer of the naturally trans-configurated Fusarium mycotoxin zearalenone is often neglected. However, isomerisation easily occurs by exposure of ZEA to (UV-)light. Thus, the applicability of the new cis-ZEA ISTD was demonstrated in a long-term isomerisation study comparing naturally trans-ZEA-contaminated edible oil with spiked edible oil. To estimate the benefits of the newly prepared cis-ZEA

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Stahl, W., A. R. Sundquist, M. Hanusch, W. Schwarz, and H. Sies. "Separation of beta-carotene and lycopene geometrical isomers in biological samples." Clinical Chemistry 39, no. 5 (1993): 810–14. http://dx.doi.org/10.1093/clinchem/39.5.810.

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Abstract The analysis of beta-carotene and lycopene, the two predominant carotenoids in human serum and tissues, was extended to the level of geometrical (cis-trans) isomers by using an improved reversed-phase HPLC methodology. We separated five geometrical isomers of beta-carotene and seven of lycopene in human serum and tissues. 13-cis-beta-Carotene was identified as the predominant cisisomer in human serum, contributing about 5% to total beta-carotene. In tissue, however, considerable amounts of 9-cis- and traces of 15-cis-beta-carotene were also detected. In contrast to beta-carotene, the

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Morita, E., J. M. Schröder, and E. Christophers. "Identification of a novel and highly potent eosinophil chemotactic lipid in human eosinophils treated with arachidonic acid." Journal of Immunology 144, no. 5 (1990): 1893–900. http://dx.doi.org/10.4049/jimmunol.144.5.1893.

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Abstract Purified human eosinophils generate eosinophil chemotactic lipids (ECL), when incubated with arachidonic acid without any stimulus. Reversed phase HPLC of incubation supernatants revealed major lipid-like eosinophil chemotactic activity eluting in a peak containing 5(S), 15(S)dihydroxy-6,13-trans-8,11-cis-eicosatetraenoic acid (5,15-DiHETE) as well as a 8,15-dihydroxyeicosatetraenoic acid. For further characterization of the ECL, some authentic dihydroxyeicosatetraenoic acids were tested for eosinophil chemotactic activity. Only 5,15-DiHETE as well as 8(S), 15(S)-dihydroxy-5,11-cis-9,

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Kirgizov, Alexey, Gulnaz Valieva, Artem Laskin, Il’dar Il’yasov та Alexander Lamberov. "Development of (γ-Al2O3-Zeolite Y)/α-Al2O3-HPCM Catalyst based on Highly Porous α-Al2O3-HPCM Support for Decreasing Oil Viscosity". Catalysts 10, № 2 (2020): 250. http://dx.doi.org/10.3390/catal10020250.

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Highly porous cellular material (α-Al2O3-HPCM) support was synthesized by the template method. Highly porous support was used for the synthesis of the catalyst. A thin secondary layer with 25–30 μ thick γ-Al2O3 and zeolite Y was applied on the α-Al2O3-HPCM surface ((γ-Al2O3 (85%)-zeolite Y (15%))/α-Al2O3-HPCM). The catalyst based on the highly porous support was tested in a process of decreasing oil viscosity. The catalyst in the form of cylindrical granules and a thermal process of decreasing oil viscosity without the catalyst were used as the basis for comparison. α-Al2O3-HPCM in the catalys

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McMahon, Adrienne, S. Christiansen, F.-F. Chee, et al. "Determination of Vitamin E and Vitamin A in Infant Formula and Adult Nutritionals by Normal-Phase High-Performance Liquid Chromatography: Collaborative Study, Final Action 2012.10." Journal of AOAC INTERNATIONAL 99, no. 1 (2016): 223–41. http://dx.doi.org/10.5740/jaoacint.15-0094.

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Abstract The main objective of the AOAC Stakeholder Panel on Infant Formula and Adult Nutritionals (SPIFAN) project is to establish international consensus methods for infant formula and adult nutritionals, which will benefit intermarket supply and dispute resolution. A collaborative study was conducted on AOAC First Action Method 2012.10 Simultaneous Determination of 13-cis and All-trans Vitamin A Palmitate (Retinyl Palmitate), Vitamin A Acetate (Retinyl Acetate), and Total Vitamin E (α-Tocopherol and D-α-tocopherol acetate) in Infant Formula and Adult Nutritionals by Normal-Phase HPLC. Fifte

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Bidlack, Mary, Linda D. Butler Thompson, Wesley A. Jacobs, and Karen J. Schimpf. "Determination of Vitamin K1 in Infant, Pediatric, and Adult Nutritionals by HPLC with Fluorescence Detection: Single-Laboratory Validation, First Action 2015.09." Journal of AOAC INTERNATIONAL 98, no. 5 (2015): 1382–89. http://dx.doi.org/10.5740/jaoacint.15-130.

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Abstract This normal-phase HPLC method with postcolumn reduction and fluorescence detection allows for the quantitative determination of trans vitamin K1 in infant, pediatric, and adult nutritionals. Vitamin K1 is extracted from products with iso-octane after precipitation of proteins and release of lipids with methanol. Prepared samples are injected onto a silica HPLC column where cis and trans vitamin K1 are separated with an iso-octane–isopropanol mobile phase. The column eluent is mixed with a dilute ethanolic solution of zinc chloride, sodium acetate, and acetic acid, and vitamin K1 is re

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Li, Yongfu, Fengying Gong, Shuju Guo, Wenjie Yu, and Jianguo Liu. "Adonis amurensis Is a Promising Alternative to Haematococcus as a Resource for Natural Esterified (3S,3′S)-Astaxanthin Production." Plants 10, no. 6 (2021): 1059. http://dx.doi.org/10.3390/plants10061059.

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Astaxanthin (AST) characteristics and pigment productivity of Adonis amurensis, one of the few AST-producing higher plants, have not yet been studied extensively. In this study, the geometrical and optical isomers of AST in different parts of the A. amurensis flower were determined in detail, followed by a separation of the all-trans AST using HPLC chromatography. AST extracted from the flower accounted for 1.31% of the dry weight (dw) and mainly existed in the di-esterified form (>86.5%). The highest concentration was found in the upper red part of the petal (3.31% dw). One optical isomer

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PANFILI, GIANFRANCO, PAMELA MANZI, and LAURA PIZZOFERRATO. "Influence of thermal and other manufacturing stresses on retinol isomerization in milk and dairy products." Journal of Dairy Research 65, no. 2 (1998): 253–60. http://dx.doi.org/10.1017/s0022029997002811.

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An analytical procedure, based upon HPLC, has been used to determine the degree of isomerization of retinol (vitamin A) in various dairy products. In raw milks, which are not subjected to thermal processing, there was no conversion of the predominant all-trans-isomers to cis-isomers in samples from various species. Pasteurized milks with mild heat treatment (high quality milk) had an average 13-cis[ratio ]all-trans ratio of 2·6%, while pasteurized milk treated for 15 s at temperatures ranging from 72 to 76°C had an average ratio of 6·4%. Milk subjected to more severe heat treatments had a high

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Assimiadis, Manolis K., Petros A. Tarantilis, and Moschos G. Polissiou. "UV-Vis, FT-Raman, and 1H NMR Spectroscopies of cis-trans Carotenoids from Saffron (Crocus sativus L.)." Applied Spectroscopy 52, no. 4 (1998): 519–22. http://dx.doi.org/10.1366/0003702981944058.

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Stigmata of Crocus sativus L. were extracted in water, and the extract was analyzed by using a high-pressure liquid chromatography (HPLC) method. The carotenoids of saffron [ cis and trans glycosyl esters of crocetin or crocins (CRCs)] were isolated, and the two major isomer compounds (all- trans-digentiobiosyl crocetin and 13- cis-digentiobiosyl crocetin) were characterized spectroscopically with ultraviolet-visible (UV-vis), Fourier transform (FT)-Raman, and 1H NMR spectroscopies. The 13 -cis compound showed in a UV-vis spectrum an additional peak at 330 nm, in an FT-Raman spectrum the prese

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Hsu, Bo-Yang, Chia-Hui Lin, and Tsai-Hua Kao. "Development of a Rapid UPLC Method for Analysis of Carotenoids in Goji Berry Extract and Evaluation of Their Transformation Affected by Saponification." Molecules 29, no. 23 (2024): 5684. https://doi.org/10.3390/molecules29235684.

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Goji berry (Lycium barbarum L.), also known as wolfberry, is a traditional Chinese medicinal herb widely utilized as a functional food ingredient throughout East Asia. In this study, we developed a rapid high performance liquid chromatography-diode array detection (HPLC-DAD) method for the simultaneous separation of carotenoids in goji berries. This method successfully separates 17 carotenoids and their esters within 21 min using a Sunrise C30 column, with detection at 450 nm, a flow rate of 1.3 mL/min, and a column temperature of 25 °C. Method validation showed intra-day precision ranging fro

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Nikolcheva, Liliya G., Christopher M. Vogels, R. Alexandra Stefan, et al. "Synthesis and in vitro reactivity of cis-dichloro-(pyridin-2-ylcarboxaldimine)platinum(II) complexes with DNA." Canadian Journal of Chemistry 81, no. 4 (2003): 269–74. http://dx.doi.org/10.1139/v03-034.

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Five platinum pyridin-2-ylcarboxaldimine complexes of the type cis-[PtCl2(2-C5H4NCH=NR)] (R = CH2CH2OH (1); R = N(CH2CH2)2O (2); R = C6H5 (3); R = 1-C10H7 (4); R = (CH2)8CH=CH(CH2)7CH3 (5)) were prepared and their in vitro reactivity towards a 20-base pair (single- and double-stranded) DNA determined using nuclease digest studies and RP-HPLC. Variation of the imine functionality allowed for the design of compounds with different physical and chemical properties. Complexes 1 and 3 showed binding to both single- and double-stranded DNA comparable to that of cisplatin (cis-[PtCl2(NH3)2]). Crystal

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Meyer, E., W. E. Lambert, and A. P. De Leenheer. "Simultaneous determination of endogenous retinoic acid isomers and retinol in human plasma by isocratic normal-phase HPLC with ultraviolet detection." Clinical Chemistry 40, no. 1 (1994): 48–51. http://dx.doi.org/10.1093/clinchem/40.1.48.

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Abstract We describe a rapid and simple procedure for the simultaneous quantitation of endogenous 13-cis-retinoic acid, all-trans-retinoic acid, and retinol by isocratic normal-phase HPLC with ultraviolet detection, in 0.5 mL of human plasma. A silica adsorption column was eluted with n-hexane:2-propanol:acetic acid (200:0.7:0.135 by vol) at 0.9 mL/min, and the effluent monitored at 350 nm. The arotinoid ethylsulfonic acid Ro 15-1570 was used as the internal standard. High sensitivity, allowing quantitation of physiological concentrations, was achieved, particularly for the retinoic acid isome

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Mazzucchi, Laura, Yanan Xu, and Patricia Harvey. "Stereoisomers of Colourless Carotenoids from the Marine Microalga Dunaliella salina." Molecules 25, no. 8 (2020): 1880. http://dx.doi.org/10.3390/molecules25081880.

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Carotenoids comprise a diverse range of naturally occurring stereoisomers, which differ in their physico-chemical properties. Their biosynthesis begins with phytoene, which is a rarity among carotenoids because it is colourless. Phytoene is sought after as a skin protectant against harmful UV range B (290–320 nm) and C (100–290 nm) light, and as a natural skin-whitening agent and is synthesized from geranylgeranyl diphosphate. Geranylgeranyl diphosphate is catalysed by phytoene synthase and phytoene desaturase to phytoene and phytofluene, respectively. The subsequent steps involve desaturation

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He, Guodong, Liping Mai, and Xipei Wang. "Development and Validation of an HPLC-MS/MS Method for Rapid Simultaneous Determination of Cefprozil Diastereomers in Human Plasma." International Journal of Analytical Chemistry 2018 (September 13, 2018): 1–9. http://dx.doi.org/10.1155/2018/6959761.

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Background. Both cis- and trans-cefprozil have antimicrobial activity, but their potencies are quite different. It is therefore necessary to develop a sensitive method to simultaneously determine both isomers for pharmacokinetic and bioequivalence studies. Methods. An LC-MS/MS method, using stable isotope-labeled cefprozil as the internal standard, was developed and validated. The analytes were extracted from plasma by protein precipitation and separated on a reverse-phase C18 column using a gradient program consisting of 0.5% formic acid and acetonitrile within 4 min. The mass spectrometry ac

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Granado, F., B. Olmedilla, I. Blanco та E. Rojas-hidalgo. "An improved HPLC Method for the Separation of Fourteen Carotenoids, Including 15-/13- and 9-CIS-β-Carotene Isomers, Phytoene and Phytofluene". Journal of Liquid Chromatography 14, № 13 (1991): 2457–75. http://dx.doi.org/10.1080/01483919108049333.

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Kimura, Mieko, та Delia Rodriguez-Amaya. "Carotenoids of tomato and tomato paste: verification of the occurrence of γ-carotene". Revista do Instituto Adolfo Lutz 62, № 1 (2003): 21–6. http://dx.doi.org/10.53393/rial.2003.62.34945.

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Tomato and tomato paste are among the most consumed foodstuffs worldwide. Although their carotenoid compositions have been widely determined, some inconsistencies can be discerned in theliterature. In Brazil, γ-carotene was detected in fresh tomato but not in various tomato products, usingopen column chromatography (OCC). On the other hand, very high amounts of this carotenoid were obtained in American tomato products, using high performance liquid chromatography (HPLC). Thus,this work was carried out to verify if the difference in data was due to natural variation or an artifact of the analys

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Panda, Subhranshu, C. H. Surya Kumari, and G. Puniya. "FORMULATION AND EVALUATION OF COMPRESSION COATING FLOATING TABLETS OF CARVEDILOL PHOSPHATE ONCE DAILY DOSE." International Journal of Pharmacy and Pharmaceutical Sciences 10, no. 6 (2018): 82. http://dx.doi.org/10.22159/ijpps.2018v10i6.25367.

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Objective: The rationale for the study was to develop a once-daily dose of immediate as well as a gastro-retentive form of carvedilol phosphate by compression coating floating technique.Methods: In the presented study the core tablet was containing half the quantity of the drug formulated as floating drug delivery using different controlled release polymers blend in various proportions like ethyl cellulose, carbopol, hydroxypropyl methylcellulose (HPMC) K4, K15, and K100 by direct compression method. Outer coat layer was formulated with rest of the drug with the blend of different super disint

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Ojimelukwe, Philippa Chinyere, and Udo U. Okpanku. "Soil Nutrient Management Practices Influence the Carotenoid Content and Profile of Orange Fleshed Sweet Potato Variety (UMUSPO 3)." Sustainable Food Production 8 (October 2020): 38–46. http://dx.doi.org/10.18052/www.scipress.com/sfp.8.38.

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Food bio fortification holds a lot of promise for the alleviation of hidden hunger. The appropriate soil nutrient management methods that will maximize the pro vitamin A content of bio fortified Orange fleshed sweet potatoes bio fortified was evaluated in the present research. The carotenoid content and profile of OFSP variety grown on soils given five different nutrient managements were compared. The soil management treatments given were: Poultry manure at 10 x 103 kg /ha (VB1); Poultry manure at 5 x 103 kg/ha;( VB2): Poultry manure at 2.5 x 103 kg/ha + NPK at 200 kg/ha + Agrolyser at 2.7 kg/

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Odion, Emmanuel Eimiomodebheki, Deborah Evelyn Elakhe, Daniel Akpe-Efiak Ambe, Chinyelu Clementina Osigwe, and Eravweroso Congrat Odiete. "Profiling of Phytochemicals in the Leaves of Asystasia gangetica (L) T. Anderson using GC-MS and HPLC Analysis." Journal of Nepal Chemical Society 44, no. 2 (2024): 23–32. http://dx.doi.org/10.3126/jncs.v44i2.68299.

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Asystasia gangetica is a perennial herb that has naturalized in Africa and Asia, where it is use in treatment of varying ailments such as lowering of blood sugar, sexually transmitted infections, reduce swelling and ear disease. The presence of phytochemicals in this plant may be responsible for its acclaimed effects. This study aims to identify the phytoconstituents in the leaves of Asystasia gangetica. Preliminary phytochemical screening was achieved by standard methods, GC-MS and HPLC analyses were utilized to determine volatile and non-volatile compounds. Phytochemicals identified include

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Kitagawa, Yuito, Sorai Kanno, Kenji Matsumoto, Yoshio Tsujino, Toshiyuki Osakai, and Hiroki Hotta. "Analysis of Redox Reaction of Caffeic Acid Under UV Irradiation By Electrochemical Measurements." ECS Meeting Abstracts MA2024-02, no. 67 (2024): 4737. https://doi.org/10.1149/ma2024-02674737mtgabs.

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Introduction Since the discovery of the French Paradox, focus on polyphenols as substances with health benefits has continued to increase. Caffeic acid (Caf, 3,4-dihydroxycinnamic acid), the subject of this study, has also focused on as a polyphenol with antioxidant activity to prevent diseases caused by reactive oxygen species. Caf is one of the major antioxidants and is present in a variety of plants, making it easily available. We have extensively studied the electrochemical properties of polyphenols including caffeic acid[1-4]. We have found that cyclic voltammograms (CV) of Caf exhibit a

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Ho, Duy Xuan, and Ki-Hyun Kim. "Evaluation of Ternary Mobile Phases for the Analysis of Carbonyl Compound Derivatives Using High-Performance Liquid Chromatography." Scientific World JOURNAL 11 (2011): 1–19. http://dx.doi.org/10.1100/tsw.2011.4.

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In this study, the feasibility of ternary mobile phases was examined in a high-performance liquid chromatography (HPLC)-based analysis of carbonyl compounds (CCs). To test the performance of different ternary phases, the liquid phase standards containing a 15 aldehyde/ketone-DNPH(o) mix were analyzed through a series of five-point calibration experiments. For this comparison, three types of ternary mobile phases were prepared initially by mixing water (W) with two of the following three organic solvents: isopropanol (I), methanol (M), and tetrahydrofuran (T). The resulting three types of terna

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Wigren, J., S. Surapureddi, AG Olsson, CK Glass, S. Hammarstrom, and M. Soderstrom. "Differential recruitment of the coactivator proteins CREB-binding protein and steroid receptor coactivator-1 to peroxisome proliferator-activated receptor gamma/9-cis-retinoic acid receptor heterodimers by ligands present in oxidized low-density lipoprotein." Journal of Endocrinology 177, no. 2 (2003): 207–14. http://dx.doi.org/10.1677/joe.0.1770207.

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Peroxisome proliferator-activated receptor gamma (PPARgamma) colocalizes with oxidized low-density lipoprotein (LDL) in foam cells in atherosclerotic lesions. We have explored a potential role of oxidized fatty acids in LDL as PPARgamma activators. LDL from patients suffering from intermittent claudication due to atherosclerosis was analyzed using HPLC and gas chromatography/mass spectrophotometry and found to contain 9-hydroxy and 13-hydroxyoctadecadienoic acid (9- and 13-HODE), as well as 5-hydroxy-, 12-hydroxy- and 15-hydroxyeicosatetraenoic acid (5-, 12- and 15-HETE respectively). PPARgamm

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O'NEAL, Kevin D., Mohan V. CHARI, Charles H. McDONALD, et al. "Multiple cis-trans conformers of the prolactin receptor proline-rich motif (PRM) peptide detected by reverse-phase HPLC, CD and NMR spectroscopy." Biochemical Journal 315, no. 3 (1996): 833–44. http://dx.doi.org/10.1042/bj3150833.

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An eight-amino-acid synthetic peptide (Ile1-Phe2-Pro3-Pro4-Val5-Pro6-Gly7-Pro8) corresponding to the conserved proline-rich motif (PRM) of the intracellular domain of the prolactin receptor (PRL-R) was studied by one- and two-dimensional (1D and 2D) proton NMR spectroscopy in water and DMSO in order to characterize its conformational dynamics. The purified PRL-R PRM peptide eluted as two partially resolved peaks in equilibrium on reverse-phase HPLC (RP-HPLC) at 20 °C with a ratio of 60:40. At 30 °C, the two peaks coalesced into a single peak. The two RP-HPLC peaks correspond to two peptide con

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Li, Ming-Hsin, Han-Chih Chang, Chun-Fang Feng, Hung-Wen Yu, and Chyng-Yann Shiue. "Synthesis and Evaluation of 18F-INER-1577-3 as a Central Nervous System (CNS) Histone Deacetylase Imaging Agent." Current Medical Imaging Formerly Current Medical Imaging Reviews 16, no. 8 (2020): 978–90. http://dx.doi.org/10.2174/1573405615666191008160809.

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Background:: Epigenetic dysfunction is implicated in many neurologic, psychiatric and oncologic diseases. Consequently, histone deacetylases (HDACs) inhibitors have been developed as therapeutic and imaging agents for these diseases. However, only a few radiotracers have been developed as HDACs imaging agents for the central nervous system (CNS). We report herein the synthesis and evaluation of [18F]INER-1577-3 ([18F]5) as an HDACs imaging agent for CNS. Methods:: [18F]INER-1577-3 ([18F]5) was synthesized by two methods: one-step (A) and two-step (B) methods. Briefly, radiofluorination of the

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Abaimov, Denis A., Rogneda B. Kazanskaya, Ruslan A. Ageldinov, et al. "Evaluation of Ouabain’s Tissue Distribution in C57/Black Mice Following Intraperitoneal Injection, Using Chromatography and Mass Spectrometry." International Journal of Molecular Sciences 25, no. 8 (2024): 4318. http://dx.doi.org/10.3390/ijms25084318.

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Cardiotonic steroids (CTSs), such as digoxin, are used for heart failure treatment. However, digoxin permeates the brain–blood barrier (BBB), affecting central nervous system (CNS) functions. Finding a CTS that does not pass through the BBB would increase CTSs’ applicability in the clinic and decrease the risk of side effects on the CNS. This study aimed to investigate the tissue distribution of the CTS ouabain following intraperitoneal injection and whether ouabain passes through the BBB. After intraperitoneal injection (1.25 mg/kg), ouabain concentrations were measured at 5 min, 15 min, 30 m

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Quraishi, Nabila, Aimen Fatima, and Shahid Mohammed. "Comparison of Co-Processed Superdisintegrants with Superdisintegrants in Drug Release for Palatable Fast Disintegrating Oral Films of Metolazone." Journal of Drug Delivery and Therapeutics 13, no. 12 (2023): 26–34. http://dx.doi.org/10.22270/jddt.v13i12.6050.

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The present study was aimed to compare co-proceesed superdisentigrant with superdisentigrants in drug release and formulate a palatable fast disintegrating oral films of metolazone and compare with standard market solid oral dosage forms. The drug was incorporated as solid dispersion to mask the bitter taste of the drug with different polymers in different ratios (PEG 4000 & Poloxomer 407) and was assessed for its taste. Metalazone with Poloxomer 407 (M-SD 5) in the ratio of 1:2 was better masked. The films were prepared by solvent casting method. HPMC E15 & Pullulan were chosen as the

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Al Subeh, Zeinab Y., Huzefa A. Raja, Jennifer C. Obike, Cedric J. Pearce, Mitchell P. Croatt, and Nicholas H. Oberlies. "Media and strain studies for the scaled production of cis-enone resorcylic acid lactones as feedstocks for semisynthesis." Journal of Antibiotics 74, no. 8 (2021): 496–507. http://dx.doi.org/10.1038/s41429-021-00432-3.

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AbstractResorcylic acid lactones (RALs) with a cis-enone moiety, represented by hypothemycin (1) and (5Z)-7-oxozeaenol (2), are fungal secondary metabolites with irreversible inhibitory activity against protein kinases, with particularly selective activity for inhibition of TAK1 (transforming growth factor beta-activated kinase 1). Gram-scale quantities of these compounds were needed as feedstock for semi-synthesizing RAL-analogues in a step-economical fashion. To do so, this study had three primary goals: identifying fungi that biosynthesized 1 and 2, enhancing their production by optimizing

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