Relevant bibliographies by topics / HPMC-AS

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Academic literature on the topic 'HPMC-AS'

Author: Grafiati
Published: 4 June 2021
Last updated: 3 February 2022

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Journal articles on the topic "HPMC-AS"

1

MAHAJAN, NILESH M., Kalyanee Wanaskar, Yogesh Bhutada, Raju Thenge, and Vaibhav Adhao. "DESIGN AND IN VITRO EVALUATION OF EXTENDED RELEASE TABLET OF NATEGLINIDE." Journal of Drug Delivery and Therapeutics 8, no. 5-s (2018): 235–39. http://dx.doi.org/10.22270/jddt.v8i5-s.2012.

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The aim of present study is to formulate and evaluate extended release matrix tablet of Nateglinide by direct compression method using different polymer like HPMC K4 and HPMC K15. Matrix tablet of nateglidine were prepared in combination with the polymer HPMC K4, HPMC K15, along with the excipients and the formulations were evaluated for tablet properties and in vitro drug release studies. Nateglinide matrix tablet prepared by using polymer such as HPMC K4 and HPMC K15, it was found that HPMC K15 having higher viscosity as compare to HPMC K4 therefore different concentration of polymer were studied to extend the drug release up to 12 h. The tablets of Nateglinide prepared by direct compression had acceptable physical characteristics and satisfactory drug release. The study demonstrated that as far as the formulations were concerned, the selected polymers proved to have an acceptable flexibility in terms of in-vitro release profile. In present the study the percent drug release for optimize batch was found to 94.62%. Hence it can be conclude that Nateglinide extended release matrix tablet can prepared by using HPMC. The swollen tablet also maintains its physical integrity during the drug release study
 Keywords: Tablet, in-vitro drug release, Nateglinide, HPMC
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2

Majee, Sutapa Biswas, Dhruti Avlani, and Gopa Roy Biswas. "HPMC AS CAPSULE SHELL MATERIAL: PHYSICOCHEMICAL, PHARMACEUTICAL AND BIOPHARMACEUTICAL PROPERTIES." International Journal of Pharmacy and Pharmaceutical Sciences 9, no. 10 (2017): 1. http://dx.doi.org/10.22159/ijpps.2017v9i10.20707.

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The most common instability problem of gelatin capsules arises from negative impact of extremes of temperature and especially atmospheric relative humidity on the mechanical integrity of the capsule shells with adverse effect extended even to the fill material. Moreover, choice of fill materials is highly restricted either due to their specific chemical structure, physical state or hygroscopicity. Additional reports of unpredictable disintegration and dissolution of filled hard gelatin capsules in experimental studies have prompted the search for a better alternative capsule shell material. The present review aims to provide an overview on the physicochemical, pharmaceutical and biopharmaceutical properties of hydroxypropyl methylcellulose (HPMC) as capsule shell material and perform comparative evaluation of HPMC and gelatin in terms of in vitro/in vivo performance and storage stability. HPMC capsule provides a highly flexible and widely acceptable platform capable of solving numerous challenges currently facing the pharmaceutical and nutraceutical industries and expands the possibilities for selection of different types of fill materials. The current topic introduces a new section on influence of various factors on in vitro dissolution of HPMC capsules. Delayed in vitro disintegration/dissolution of HPMC capsules in aqueous medium does not produce any negative effect in vivo. However, advancements in the processes of production and filling of HPMC capsule shells and detailed studies on effects of various parameters on their in vitro/in vivo dissolution would establish their supremacy over hard gelatin capsules in future.
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3

Maffione, G., P. Iamartino, G. Guglielmini, and A. Gazzaniga. "High-Viscosity HPMC as a Film-Coating Agent." Drug Development and Industrial Pharmacy 19, no. 16 (1993): 2043–53. http://dx.doi.org/10.3109/03639049309069340.

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4

Yao, Risheng, Jiajia Xu, Xihua Lu, and Shengsong Deng. "Phase Transition Behavior of HPMC-AA and Preparation of HPMC-PAA Nanogels." Journal of Nanomaterials 2011 (2011): 1–6. http://dx.doi.org/10.1155/2011/507542.

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The lower critical solution temperature (LCST) of hydroxypropyl methylcellulose (HPMC) under mixing with acrylic acid (AA) monomer has been studied by turbidity measurements. It has been found that the LCST of the HPMC was drastically reduced from 60°C to 38°C with the increase of the concentration of AA, while the HPMC is kept at 0.5 wt%. The driving force shifting the LCST is attributed to the hydrogen bonding and hydrophobic interaction of the molecules. Then surfactant-free HPMC-PAA nanogels have been synthesized via the polymerization of AA monomer with the collapsed HPMC as a template or core at their LCST, using KPS and TEMED as redox initiator in the presence of BIS as cross-linking agent. HPMC-PAA nanogels have 50~150 nm diameters characterized by transmission electron microscope and dynamic light scattering. The HPMC-PAA nanogels exhibit the temperature phase transition behaviors, and these nanogels' volume phase transition temperature is close to the LCST of HPMC/AA system.
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5

Chen, Yuejie, Shujing Wang, Shan Wang, et al. "Sodium Lauryl Sulfate Competitively Interacts with HPMC-AS and Consequently Reduces Oral Bioavailability of Posaconazole/HPMC-AS Amorphous Solid Dispersion." Molecular Pharmaceutics 13, no. 8 (2016): 2787–95. http://dx.doi.org/10.1021/acs.molpharmaceut.6b00391.

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6

Moonprasith, N., S. Loykulnant, and C. Kongkaew. "Use of Hydroxypropylmethylcellulose as Thermo-Responsive Flocculant in Skim Natural Rubber Latex." Advanced Materials Research 55-57 (August 2008): 913–16. http://dx.doi.org/10.4028/www.scientific.net/amr.55-57.913.

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To recover residual rubber from skim natural rubber (SNR) latex, the effective and environmentally friendly methodology developed based on using hydroxypropylmethylcellulose (HPMC) as a thermo-responsive flocculant. The SNR particles could be completely separated to form high concentrated latex as cream phase within only 5 hours. Almost 100% of SNR was recovered when using HPMC 0.7%w/w. Quality of SNR obtained from this technique was higher and color of it was lighter than SNR obtained from the conventional method. HPMC could be easily precipitated from the serum phase by heating the serum phase at about 70 °C. The cloud point and the precipitation point of HPMC were affected by the additions of α-D-glucose, sn-phosphatidyl chloride and inorganic salts. It was found that reduction of the cloud point and the precipitation point of HPMC also depended on both concentration and type of cations and anions of inorganic salts.
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7

Zheng, Jiao, Bo Wang, Jia Xiang, and Zhengyu Yu. "Controlled Release of Curcumin from HPMC (Hydroxypropyl Methyl Cellulose) Co-Spray-Dried Materials." Bioinorganic Chemistry and Applications 2021 (June 15, 2021): 1–6. http://dx.doi.org/10.1155/2021/7625585.

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In order to achieve the controlled release of curcumin, HPMC (hydroxypropyl methyl cellulose) was spray dried with curcumin and lactose. The spray-dried materials were pressed into tablets with a diameter of 8 mm, and their release characteristics in vitro were measured. In vitro experiments showed that the release of curcumin from the HPMC mixture was significantly slower due to the sustained-release property of HPMC as a typical excipient. The release profile of curcumin from the HPMC mixture was relatively stable for a controlled release. SEM images show that the HPMC co-spray-dried powders have crumpled surfaces due to the large molecular weight of HPMC. DSC, XRD, FTIR, N2 adsorption, and TGA have been measured for the spray-dried curcumin materials. This work indicates that HPMC can be used as a controlled-release excipient for curcumin preparations.
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8

Ding, Zhu, Xiaodong Wang, Jay Sanjayan, Patrick Zou, and Zhi-Kun Ding. "A Feasibility Study on HPMC-Improved Sulphoaluminate Cement for 3D Printing." Materials 11, no. 12 (2018): 2415. http://dx.doi.org/10.3390/ma11122415.

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A novel 3D printing material based on hydroxypropyl methylcellulose (HPMC)—improved sulphoaluminate cement (SAC) for rapid 3D construction printing application is reported. The hydration heat, setting time, fluidity of paste and mortar, shape retainability, and compressive strength of extruded SAC mortar were investigated. HPMC dosage, water-to-cement (W/C) ratio, and sand-to-cement (S/C) ratio were studied as the experimental parameters. Hydration heat results reveal HPMC could delay the hydration of SAC. The initial and final setting time measured using Vicat needle would be shortened in the case of W/C ratio of 0.3 and 0.35 with HPMC dosage from 0.5% to 1.5%, W/C ratio of 0.40 with HPMC dosage of 0.5%, 0.75%, and 1.5%, and W/C ratio of 0.45 with HPMC dosage of 0.45, or be extended in the case of W/C ratio of 0.4 with HPMC dosage of 1.0% and W/C ratio of 0.45 with HPMC dosage from 0.75% to 1.5%. Fluidity measurement shows HPMC significantly improves the shape retainability. Furthermore, the addition of HPMC remarkably increased the compressive strength of extruded mortar. The results showed that HPMC could be used to prepare 3D printing SAC having satisfactory shape retainability, setting time and compressive strength.
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9

Sungthongjeen, Srisagul, Pornsak Sriamornsak, and Satit Puttipipatkhachorn. "Design of Floating HPMC Matrix Tablets: Effect of Formulation Variables on Floating Properties and Drug Release." Advanced Materials Research 311-313 (August 2011): 1140–43. http://dx.doi.org/10.4028/www.scientific.net/amr.311-313.1140.

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Floating matrix tablets were designed and evaluated. Theophylline was used as a model drug. The system was prepared by mixing drug, matrix-forming polymer (hydroxypropyl methylcellulose, HPMC) and fillers together. The blended powder was compressed by hydraulic press. The effect of formulation variables such as type of matrix forming polymer (HPMC K100LV, HPMC K4M, HPMC K100M), amount of effervescent agent (0, 20, 30, 40% w/w) and compression force (0.5, 1 ton) on floating properties and drug release of floating matrix tablets were investigated. The results demonstrated that type of polymer affected floating properties of the floating matrix tablets. The floating matrix tablets prepared from lower viscosity HPMC (HPMC K100LV) showed faster drug release than those prepared from higher viscosity HPMC (HPMC K4M, HPMC K100M). Increasing amount of effervescent agent decreased time to float and increased drug release from the floating matrix tablets. Higher compression force did not affect time to float but decreased drug release from the floating matrix tablets. According to these results, floating properties and drug release of the floating matrix tablets could be modified by formulation variables. Some floating tablet formulations developed in this study showed good floating properties (time to float less than 15 minutes, floating time more than 8 hours) with sustained release as required. The system is promising as a carrier for gastroretentive drug delivery systems.
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10

Kraisit, Pakorn, Manee Luangtana-Anan, and Narong Sarisuta. "Effect of Various Types of Hydroxypropyl Methylcellulose (HPMC) Films on Surface Free Energy and Contact Angle." Advanced Materials Research 1060 (December 2014): 107–10. http://dx.doi.org/10.4028/www.scientific.net/amr.1060.107.

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The aim of this study was to investigate the physicochemical characteristics of various viscosity grades of hydroxypropyl methylcellulose (HPMC) for mucoadhesive buccal films. The HPMC used in this study was K4M, K15M and K100M which their viscosity were 4000, 15000 and 100000 mPas respectively. Using HPMC as film forming base matrix, all intrinsic characteristics of each HPMC grade is required as basic knowledge for the development of mucoadhesive buccal films. To understand the primary essential parameters, surface free energy and contact angle of various HPMC grades were determined. Sessile drop technique was used in this study to determine contact angle of HPMC and surface free energy was then evaluated by using the Wu’s equation. The results showed that the increase in viscosity of HPMC film tended to decrease the polar force and total surface free energy but increased the contact angle. These parameters indicated that the hydrophilic character of HPMC was influenced by its viscosity. Our study suggested that the polar and dispersive force detected by sessile drop technique could be beneficial for the further design and development of mucoadhesive buccal films.
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