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Journal articles on the topic 'HPMC etc'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

G.Jagadeesh*, Dr.Vijaya Kuchana. "DESIGN AND INVITRO CHARACTERIZATION OF GASRO RETENTIVE MUCOADHESIVE FLOATING TABLETS OF METFORMIN HCL." Indo American Journal of Pharmaceutical Sciences 04, no. 09 (2017): 3202–9. https://doi.org/10.5281/zenodo.936410.

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In the present research work gastro retentive mucoadhesive floating formulation of Metformin was developed by using various hydrophilic polymers. Initially analytical method development was done for the drug molecule. Absorption maxima was determined based on that calibration curve was developed by using different concentrations. Gas generating agent accrual and bioadhesive polymer carbopol concentration was optimized. Then the formulation was developed by using different concentrations of polymers of various polymers. The formulation blend was subjected to various preformualation studies, flo

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Bhandari, Yash, Sunayana Rathore, Vaishali Raghuwanshi, Shehnaz Sheikh, Yashmita Sharma, and Ishan Dubey. "A Practical Approach for Solubility Enhancement of Leflunomide." Oriental Journal Of Chemistry 39, no. 5 (2023): 1386–88. http://dx.doi.org/10.13005/ojc/390537.

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Leflunomide is an anti-rheumatic medication. As it has low water solubility, it shows low absorption in gastrointestinal tract. The reported solubility of Leflunomide is approx 25.27 mcg/ml. Leflunomide comes under BCS Class II in which it has low solubility and high permeability. In this study, gel entrapment technique is used to enhance the solubility of leflunomide. In this technique Hydroxy Propyl Methyl Cellulose and Ethyl Cellulose are used which are converted to gel with the addition of different organic solvent such as Ethanol, Chloroform, Di chloro Methane etc. The analyses of the sam

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Katona, Jaroslav, Alena Tomsik, Sandra Bucko, and Lidija Petrovic. "Influence of ionic strength on the rheological properties of hydroxypropylmethyl cellulose-sodium dodecylsulfate mixtures." Acta Periodica Technologica, no. 46 (2015): 229–37. http://dx.doi.org/10.2298/apt1546229k.

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Mixtures of polymers and surfactants are commonly found in a range of products of pharmaceutical, cosmetic, and food industry. Interaction between polymers and surfactants influences different properties of these products, e.g. stability, flow properties, phase behavior, etc. It is known from previous work that an interaction in binary mixtures of hydroxypropylmethyl cellulose (HPMC) and sodium dodecylsulfate (SDS) takes place when SDS concentration (CSDS.) is higher than the critical association concentration (CAC) and lower than the polymer saturation point (PSP). The interaction results in

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Saletic, Jelena, Verica Sovilj, and Lidija Petrovic. "Influence of hydroxypropylmethyl cellulose-sodium laurylsulfate interaction on rheological properties of the solution." Chemical Industry 58, no. 11 (2004): 521–25. http://dx.doi.org/10.2298/hemind0411521s.

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Interactions between the polymers and surfactants in solution have widely been investigated because of their scientific and technological importance. These interactions can be utilized to modify the physicochemical properties of system in many food products, pharmaceutical formulations, personal care products, paints, pesticides, etc. Interaction between nonionic polymer - hydroxypropylmethyl cellulose (HPMC) and anionic surfactant - sodium laurylsulfate (SDS) in solution has been investigated in this paper by rheological measurements. Rheological measurements are performed by rotational visco

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Padmaja, B., and S. Shobha Rani. "Formulation development and characterization of Lecarnidipine hydrochloride niosomal transdermal patches." Journal of Drug Delivery and Therapeutics 13, no. 8 (2023): 100–109. http://dx.doi.org/10.22270/jddt.v13i8.5942.

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The bioavailability of Lercanidipine Hydrochloride (LCP) is about 44% and half-life of the drug is about 4.6 hours. LCP due to its low therapeutic dose range of 2.5 to 20mg and substantial biotransformation in liver becomes it ideal molecule in development of transdermal therapeutic system. The primary objective of the present research work was to develop Niosomal transdermal patch (NP) of Lecarnidipine. The LCP nanoparticles were prepared by solvent evaporation method and the optimized Nanoparticles formulation has shown 225nm particle size with a polydispersity index (PDI) of 0.120. LCP patc

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Patel, B. P., and D. M. Patel. "DESIGN OF DUAL RELEASE DRUG DELIVERY SYSTEM OF ROXYTHROMYCIN AND AMBROXOL HYDROCHLORIDE." INDIAN DRUGS 53, no. 10 (2016): 27–33. http://dx.doi.org/10.53879/id.53.10.10582.

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Upper respiratory tract infections (URTIs) are illnesses caused by an acute infection which involves the upper respiratory tract: nose, sinuses, pharynx or larynx. Roxithromycin (macrolide antibiotic) and ambroxol HCl (mucolytic) are used for this treatment. The dual release system of roxythromycin and ambroxol HCl was successfully prepared by bi-layer tablet approach for management of URTI. Quick release of roxithromycin was achieved by using disintegrants and slow release of ambroxol HCl was achieved by using matrix formulation of drug with HPMC K4M and ethyl cellulose. The 32 full factorial

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Suksaeree, Jirapornchai, Wiwat Pichayakorn, Patsakorn Siripornpinyo, Somruethai Chaiprasit, and Pattwat Maneewattanapinyo. "Low Protein Natural Rubber Latex - Based Polymer Blends for Transdermal Patches of Mefenamic Acid." Key Engineering Materials 859 (August 2020): 34–38. http://dx.doi.org/10.4028/www.scientific.net/kem.859.34.

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Transdermal patches are attraction and acceptance for the patient due to avoid first-pass metabolism, easy to administer and removal, allows rapid termination of treatment if required etc. Low protein natural rubber latex (LPNRL) is a natural polymer that removed the allergic protein from fresh NRL prepared by treatment with proteolytic enzyme and centrifuging process. LPNRL is used for medical skin applications with the non-allergenic product. The objective of this research aimed to prepare the mefenamic acid – loaded transdermal patches made from LPNRL blended with either hydroxypropyl methy

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8

L., Lahari *. E. Hima bindu Dr. Sowjanya battu Dr. Abbulu. "FORMULATION, DEVELOPMENT AND EVALUATION OF ANTI-DIABETIC ORAL INSITU GEL." Journal of Pharma Research 8, no. 8 (2019): 572–83. https://doi.org/10.5281/zenodo.3374091.

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<strong><em>ABSTRACT</em></strong> <strong><em>T</em></strong><em>he present research was focused to develop the formulation to release the drug Repaglinide for an extended period of time, thus prolong the residence time of formulation in the intestine. The in-situ gel formulations were developed to improve patient compliance. HPMC 50 cps, Carbopol 934 is used as polymers. Based on the concentration of polymer, the drug release was varied. Totally 12 formulations were prepared with HPMC 50cps and Carbopol 934P in various combinations. An in-vitro evaluation study was conducted in Franz diffusi

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Verma, Amit Kumar, Arun Kumar, Subbiah Ramasamy, Ajit Kumar Yadav, and Rohit Kumar Bijauliya. "Evaluation of Drug Release from Carboxymethyl Starch-Xanthan Gum-HPMC Matrix." Journal of Drug Delivery and Therapeutics 11, no. 5 (2021): 27–32. http://dx.doi.org/10.22270/jddt.v11i5.5000.

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The use of hydrophilic polymers from natural origin. Especially the polysaccharides have been the focus of current research activity in the design of matrix device due to their non toxic, biocompatible, biodegradable nature and broad regulatory acceptance. A large number of polysaccharides such as Carboxymethyl starch, Xanthan gum, Hydroxy propyl methyl cellulose (HPMC), Sodium Alginate etc, have been used as hydrophilic matrices to investigate release behavior of drug. In order to enrich the resources, there is a quest for new polysaccharide owing to their diverse chemical composition and fun

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Kodalkar, Swapnil J., Rohan A. Khutale, Sachin S. Salunkhe, Sachin S. Mali, and Sameer J. Nadaf. "Implementation of time release technology in formulation development and evaluation of sustained release tablet of Lornoxicam." Indian Journal of Pharmaceutical and Biological Research 2, no. 01 (2014): 68–75. http://dx.doi.org/10.30750/ijpbr.2.1.11.

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In present study, the attempts have been made to formulate sustained release tablets of lornoxicam by direct compression method. Based on viscosity grades different proportions of hydrophilic polymers (HPMC K4M, HPMC K15M, HPMC K100M) are used for preparation of lornoxicam sustained release matrix tablet. The drug excipient mixtures were subjected to preformulation studies comprising of micromeritic properties. The tablets were subjected to various studies like as physicochemical studies, in vitro drug release, kinetic studies, etc. FTIR studies shown there was no interaction between drug and

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Hanif, Sana, Nadeem Irfan, Zeeshan Danish, et al. "Computer Aided Formulation and Characterization of Propranolol Hcl Buccal Tablet Using Polymeric Blend." Open Conference Proceedings Journal 8, no. 1 (2017): 1–13. http://dx.doi.org/10.2174/2210289201708011001.

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The current study was aimed to formulate a continuous release mucoadhesive buccal tablet containing propranolol HCl. The type and quantities of polymers as well as method of compression were set in a preliminary study (F1-F13). Direct compression method was employed in the main study (F14-F24) using Carbopol® 934P (CP), ethylcellulose (EC), sodium alginate (SA), hydroxypropyl methylcellulose (HPMC k4M) and carboxymethylcellulose (CMC) as mucoadhesive polymers and were tested for physicochemical tests i.e. swellability, surface pH, mucoadhesive time, mucoadhesive strength, in vitro release etc.

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Vijayashree, K., and K. Sheshappa Rai. "Impact of Nanosized CuO Insertion on Structural and Mechanical Properties of PVA: HPMC Based Polymer Blend Nanocomposites." Asian Journal of Chemistry 33, no. 10 (2021): 2287–92. http://dx.doi.org/10.14233/ajchem.2021.23328.

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Insertion of metal-oxide nanoparticles to polymers stipulate the modification of physical properties of polymers over and above the accomplishment of new features in the polymer matrix. In the current study, an attempt was made to disperse the CuO nanoparticles in the polyvinyl alcohol and hydroxypropyl methylcellulose (HPMC) blend to investigate the structural, mechanical and optical properties of the nanocomposite. Blend was prepared in different ratios using PVA and HPMC, viz. 25:50, 50:50 and 75:25 wt%. The CuO nanoparticles were added to the 75:25 PVA:HPMC blend in different percentage li

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Deshmukh, Aishwarya V., Gawande SR, and Chandewar AV. "Review on: Floating Drug Delivery System." Der Pharma Chemica 15, no. 6 (2023): 4. https://doi.org/10.5281/zenodo.13353444.

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Floating matrix tablets were developed to prolong gastric residence time and increase drug absorption further increasing the bioavailability. Various forms of gastro retentive drug delivery system, such as floating and non-floating. Floating tablets was formulated to increase gastric residence and there by improve its therapeutic efficacy. By using different polymers such as carbopol, guargum, HPMC K100, HPMCK4 etc. Formulated tablets showed satisfactory results for various post compression evaluation parameters like thickness, hardness, weight variation, floating lag time, total floating time

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Aishwarya, V. Deshmukh, Gawande SR, and Chandewar AV. "Review on: Floating Drug Delivery System." DER PHARMA CHEMICA 15, no. 6 (2023): 4. https://doi.org/10.4172/0975-413X.15.6.142-146.

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Floating matrix tablets were developed to prolong gastric residence time and increase drug absorption further increasing the bioavailability. Various forms of gastro retentive drug delivery system, such as floating and non-floating. Floating tablets was formulated to increase gastric residence and there by improve its therapeutic efficacy. By using different polymers such as carbopol, guargum, HPMC K100, HPMCK4 etc. Formulated tablets showed satisfactory results for various post compression evaluation parameters like thickness, hardness, weight variation, floating lag time, total floating time

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Rony, Farzana Khan, Georgia Kimbell, Toby R. Serrano, Destinee Clay, Shamsuddin Ilias, and Mohammad A. Azad. "Extrusion-Based 3D Printing of Pharmaceuticals—Evaluating Polymer (Sodium Alginate, HPC, HPMC)-Based Ink’s Suitability by Investigating Rheology." Micromachines 16, no. 2 (2025): 163. https://doi.org/10.3390/mi16020163.

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Three-dimensional printing is promising in the pharmaceutical industry for personalized medicine, on-demand production, tailored drug loading, etc. Pressure-assisted microsyringe (PAM) printing is popular due to its low cost, simple operation, and compatibility with heat-sensitive drugs but is limited by ink formulations lacking the essential characteristics, impacting their performance. This study evaluates inks based on sodium alginate (SA), hydroxypropyl cellulose (HPC H), and hydroxypropyl methylcellulose (HPMC K100 and K4) for PAM 3D printing by analyzing their rheology. The formulations

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Soni, Shivani, Vivek Jain, Sunil Kumar Jain, and Pushpendra Kumar Khangar. "Formulations of sustained release matrix tablets of Furosemide using natural and synthetic polymers." Journal of Drug Delivery and Therapeutics 11, no. 5 (2021): 105–9. http://dx.doi.org/10.22270/jddt.v11i5.5122.

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The primary benefit of a sustained release dosage form compared to a conventional dosage form, is the consistent drug plasma concentration and consequently uniform therapeutic effect. Matrix system are preferential because of their ease, patient compliance etc, than traditional drug delivery which have several drawbacks like reiterated administration, variation in blood concentration level etc. The aim of the present research study was to develop and evaluate sustained release matrix tablets of furosemide using direct compression method using natural gummy and waxy materials (Xanthan gum, bees

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Kulkarni, Gururaj S., Prabhansh P. Chaudhary, and Shivakumar Swamy. "Formulation and Evaluation of Sustained Release Floating Tablets of an Antihypertensive Diltiazem." International Journal of Pharmaceutical Sciences and Nanotechnology 10, no. 5 (2017): 3844–52. http://dx.doi.org/10.37285/ijpsn.2017.10.5.5.

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The aim of the present study was to develop and evaluate sustained release floating tablets of Diltiazem hydro-chloride, an antihypertensive agent. The sustained release floating tablets were prepared by direct compression method and formulated using different polymer combinations, formulations such as F1 to F9. Natural polymer Sodium alginate and synthetic polymer HPMC K4M were used. Developed formulations were evaluated for the pre compression parameters i.e., drug- excipients compatibility by FTIR, bulk density, compressibility, and angle of repose etc. Post compression parameters i.e. weig

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18

Patel, Vishal, Chintankumar Patel, Brijesh Patel, and Hetal Thakkar. "Formulation and evaluation of raloxifene hydrochloride dry emulsion tablet using solid carrier adsorption technique." Therapeutic Delivery 12, no. 7 (2021): 539–52. http://dx.doi.org/10.4155/tde-2021-0025.

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Aim: The present study focused on the development of a dry emulsion tablet of raloxifene hydrochloride (RXF) using a solid carrier adsorption technique to enhance oral bioavailability. Methods: An oil-in-water emulsion was formulated and converted into dry powder using HPMC K4M plus Aerosil 200, then compressed into tablets. Results: The prepared emulsion was evaluated for globule size, drug content and zeta potential. In vitro release study revealed significantly higher release from emulsion. The prepared tablets possessed acceptable hardness, friability, weight variation, disintegration time

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Thakur, Shobhana, Dolly Jain, and Shiv Kumar Prajapati. "DEVELOPMENT AND CHARACTERIZATION OF SUSTAINED RELEASE GASTRO-RETENTIVE FLOATING TABLETS OF AMBROXOL HYDROCHLORIDE." INTERNATIONAL JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH (IJPER) 4, no. 1 (2022): 43–49. http://dx.doi.org/10.37021/ijper.v4i1.6.

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Introduction: The objective of this study was to formulate floating tablets of Ambroxyl hydrochloride (AMB HCl) using the dry granulation technique to increase its bioavailability and the gastric residence time (GRT) of the dosage form. Materials and Methods: The gastro-retentive floating tablets of Ambroxol hydrochloride (AMB HCl) were prepared by direct compression method using different concentrations of polymers such as HPMC K4, HPMC K15 and PVP K30, gas releasing agents (Sodium bicarbonate and citric acid) and diluents (Microcrystalline cellulose). Citric acid was also used as an antioxid

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Pandya, Vishva, Ms Krupa Patel, and Prerna Patel. "Formulation and Evaluation of Polyherbal Face Gel." International Journal of Research and Innovation in Applied Science X, no. V (2025): 588–93. https://doi.org/10.51584/ijrias.2025.100500053.

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This study investigates the formulation and evaluation of a polyherbal face gel incorporating extracts from Aloe vera, Salvia Rosmarinus, Azadirachta indica etc. known for their skin-benefiting properties. The objective was to develop a stable and efficacious topical formulation for potential cosmetic applications, leveraging the synergistic effects of multiple plant extracts. The polyherbal extracts were prepared using decoction extraction method. The gel base was prepared using agar-agar, HPMC, xanthan gum. The formulated polyherbal face gel was then evaluated for various physicochemical par

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Paramitha, Ratih, Taranipa Marfitania, Ria Januarti, Said Hanief, and Pravil Mistryanto Tambunan. "Formulation and evaluation of red ginger extract tablet (Zingiber officinale var. rubrum) as lozenges." Jurnal Prima Medika Sains 6, no. 1 (2024): 6–11. http://dx.doi.org/10.34012/jpms.v6i1.5256.

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Red ginger (Zingiber officinale var. rubrum) with a high content of phenols (e.g. gingerol, shogaol, etc.) has potential effects against throat inflammation such as cold, sore throat, tonsilitis, etc. This research aims to determine the formulation of lozenge tablets using red ginger extracts. Lozenges tablets are made from dry ginger extract using a wet granulation method prepared by various concentrations of pregelatinized cassava starch 1 % w/v (F0); 2 % w/v (F1) and 5 % w/v (F2) as a binder and HPMC 2 % w/v (F3) as a comparative binder. Red ginger extract was prepared by maceration method

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Shital, Misal, Pawar Jaydeep, and landge Dhananjay. "FORMULATION AND EVALUATION OF A MUCOADHESIVE BUCCAL TABLET OF TELMISARTAN." INTERNATIONAL JOURNAL OF CURRENT RESEARCH AND INNOVATIONS IN PHARMA SCIENCES 1, no. 1 (2022): 53–60. https://doi.org/10.5281/zenodo.8018232.

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Indresh. "FORMULATION AND EVALUATION OF TRANSDERMAL PATCHES OF METOPROLOL SUCCINATE." Journal of Biomedical and Pharmaceutical Research 10, no. 1 (2021): 52–58. http://dx.doi.org/10.32553/jbpr.v10i1.837.

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The anti-hypertensive transdermal patches in the perspective of enhancing the bioavailability as well as in improving patient compliance, it has appear as a substitute for oral route permit self-administration, controlled and sustained drug delivery. This study will investigate the effects of metoprolol Succinate in treatment of hypertension with the interaction of hydroxy propyl methyl cellulose and ethyl cellulose. The present research work concludes that the patches prepared with different ratios of polymers shows sustained drug release for long period of time confirms that the delivery sys

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Sahil, N. Kamble*1 Radhika S. Subhedar2 Nilesh Chougale3. "Preparation And Evaluation Oral Buccal Patches Of Ambroxol Hydrochoride As Mucolytic." International Journal in Pharmaceutical Sciences 2, no. 8 (2024): 3478–93. https://doi.org/10.5281/zenodo.13349354.

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This study aims to develop and evaluate oral buccal patches containing Ambroxol Hydrochloride (AH) for its mucolytic effects. Buccal patches offer advantages such as bypassing first-pass metabolism, sustained drug release, and improved patient compliance. Buccal patches were prepared using the solvent casting method with various polymers including Hydroxypropyl methylcellulose (HPMC), methyl alcohol, citric acid, etc were incorporated as plasticizers to enhance flexibility. The formulated buccal patches demonstrated uniform thickness and weight, satisfactory folding endurance, and appropriate

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Mehmood, Salman, Syed Muhammad Farid Hasan, Rabia Noor, et al. "Influence of Prunus domestica gum on the release profiles of propranolol HCl floating tablets." PLOS ONE 17, no. 8 (2022): e0271442. http://dx.doi.org/10.1371/journal.pone.0271442.

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Propranolol hydrochloride is a beta-blocker used for the management and treatment of hypertension, angina, coronary artery disease, heart failure, fibrillation, tremors, migraine etc. The objective of the present study was to design Propranolol Hydrochloride floating tablets by direct compression method and to explore the role of a new gum as a matrix former. A 22 full factorial design was selected for the present study. Prunus domestica gum and HPMC (K4M) were used as independent variables, swelling index and drug dissolution at 12 hours as dependent variables. Formulations were subjected to

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Ujjwal, Kukreti, Nainwal Nidhi, Ale Yogita, et al. "Release Kinetic of Sustained Release Matrix Tablet of Linezolid Containing Polymer Blend." INTERNATIONAL JOURNAL OF PHARMACEUTICAL QUALITY ASSURANCE 15, no. 03 (2024): 1479–84. http://dx.doi.org/10.25258/ijpqa.15.3.60.

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Tuberculosis (TB) is a bacterial infection mainly affecting the lungs. TB is a major health problem worldwide and the occurrence of extensively drug-resistant TB (XDR-TB) and multidrug-resistant TB (MDR-TB) offers considerable hurdles to effective treatment and disease management. The growth of treatment-resistant Mycobacterium TB strains has prompted the investigation of alternate therapeutic techniques, including the application of sustained drug delivery. Sustained-release drugs reduce the need for frequent dosing can extend the effects of linezolid by 8 to 12 hours, thus improving the pati

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Pramanik, Arunima, Rudra Narayan Sahoo, Souvik Nandi, Ashirbad Nanda, and Subrata Mallick. "Characterization of Hydration Behaviour and Modeling of Film Formulation." Acta Chimica Slovenica 68, no. 1 (2021): 159–69. http://dx.doi.org/10.17344/acsi.2020.6298.

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Hydration behavior of hydrogel-based polymeric film possesses great importance in mucosal drug delivery. Modified Lag phase sigmoid model was used for the investigation of hydration of the film. Kaolin incorporated HPMC K100LVCR (HL) and K100M (HH) films containing dexamethasone as a model drug have been prepared for studying swelling kinetics. Swelling of HL and HH films was decreased with the gradual increase of kaolin content and HH of higher viscosity has shown higher value than HL matrix. Kaolin also inhibited the film erosion process. Mathematically modified lag phase sigmoid model demon

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Archana, D. Kajale, and Chandewar AV. "Formulation and evaluation of oral floating In situ gel of Tramadol hydrochloride." Pharmaceutical and Chemical Journal 3, no. 2 (2016): 267–79. https://doi.org/10.5281/zenodo.13754260.

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<em>In situ </em>gel forming systems have been widely investigated as vehicles for sustained drug delivery. <em>In situ </em>gel formation occurs due to one or combination of different stimuli like pH change, temperature modulation and solvent exchange. So, <em>In situ </em>gelling system via different route such as oral, nasal, ophthalmic etc can be formulated. In the present research work Oral Floating Insitu gel of Tramadol Hydrochloride was formulated using Eudragit L100, Eudragit S100, Eudragit RSPO, Ethyl cellulose, HPMC K100M. The optimized batch gave drug release for 12 hrs in the poly

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Santosh Kumar, Rada, and K. P. R. Chowdary. "Preparation and characterization of Starch–Urea–Borate: A new floating polymer." Journal of Drug Delivery and Therapeutics 9, no. 2 (2019): 280–84. http://dx.doi.org/10.22270/jddt.v9i2.2565.

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In recent years considerable attention has been focused on the development of new drug delivery systems known as controlled release drug delivery systems. Such interest is based largely on the fact that the controlled release products have established and retained place in the market based on their uniqueness and their clinical advantages in the practices of medicine. The major types of controlled release systems include matrix tablets, floating tablets, swellable tablets, coated beads, microcapsules and microspheres, mucoadhesive systems, ion exchange resin complexes, osmotic pressure control

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Begum, M. Yasmin, and Ali Alqahtani. "Characterization of bilayered matrix-type mucoadhesive buccal films containing tizanidine hydrochloride and piroxicam." Tropical Journal of Pharmaceutical Research 20, no. 11 (2021): 2241–48. http://dx.doi.org/10.4314/tjpr.v20i11.1.

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Purpose: To formulate and characterize tizanidine hydrochloride (TZN) and piroxicam (PRX)-loaded bilayer mucoadhesive buccal films with an intention to improve the bioavailability and patient compliance in pain management.Methods: Bilayer buccal films were prepared by solvent evaporation technique using hydroxypropyl methylcellulose (HPMC) 15cps and polyvinylpyrrolidone (PVP K30 as immediate release (IR) layer forming polymers and HPMC K15 M, PVP K 90 along with various muco adhesive polymers (Carbopol P934, sodium alginate, etc), as sustained release (SR) layer forming polymers. The prepared

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Archana, B., Balla Vaishnavi, Kannayyagari Sindhu, Keesari Meena Goud, and D. Sai Poojitha. "Formulations and evaluations of repaglinide microspheres by ionotropic gelation technique." International Journal of Experimental and Biomedical Research 4, no. 1 (2025): 1–8. https://doi.org/10.26452/ijebr.v4i1.696.

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The current study aimed to formulate and evaluate Repaglinide microspheres utilizing the ionotropic gelation process, with sodium alginate, HPMC, and Carbopol as polymers and Cacl2 as a cross-linking agent. Because of its high biocompatibility and lack of toxicity, sodium alginate is a biodegradable natural polymer with considerable promise for therapeutic uses. Repaglinide microspheres offer desirable qualities. The ionotropic gelation approach allows for high medication integration in microspheres without harmful agents that have adverse side effects. The microspheres are tested for percenta

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Karandule, Akshay, Komal Madake, Rajeshwari Khairnar, and Rupali Tasgaonkar. "Tablet Binders." International Journal for Research in Applied Science and Engineering Technology 11, no. 1 (2023): 675–81. http://dx.doi.org/10.22214/ijraset.2023.48663.

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Abstract: The tablet formulation contains binders that increase the interparticulate bond power inside the tablet. Research and progress of novel accessories remains a priority for potential use as a binder in formulations tablet. Tablet binder or binding agent are the substances that are added either dry or in liquid form during wet granulation to form granules or to promote cohesive compacts for directly compressed tablets. E.g., starch, pregelatinized starch, PEG, sorbitol, and HPMC, etc. Tablet Binder and disintegrants have the opposite used in an oral solid formulation. Binder delay table

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Rajeshwari Gokul Khairnar, Ashwini Ramdas Darade, and Rupali Rajesh Tasgaonkar. "A review on tablet binders as a pharmaceutical excipient." World Journal of Biology Pharmacy and Health Sciences 17, no. 3 (2024): 295–302. http://dx.doi.org/10.30574/wjbphs.2024.17.3.0142.

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The tablet formulation contains binders that increase the inter-particulate bond power inside the tablet. Research and progress of novel accessories remains a priority for potential use as a binder in formulations tablet. Tablet binder or binding agent are the substances that are added either dry or in liquid form during wet granulation to form granules or to promote cohesive compacts for directly compressed tablets. E.g., starch, pregelatinized starch, PEG, sorbitol, and HPMC, etc. Tablet Binder and disintegrants have the opposite used in an oral solid formulation. Binder delay tablet disinte

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Abhishek, Soni 1. *. Dr. Amit Chaudhary 1. Dr. Shivali Singla 2. Dr. Sachin Goyal 2. "REVIEW ON: NOVEL APPROACH IN PHARMACEUTICAL GEL." Journal of Pharma Research 8, no. 6 (2019): 429–35. https://doi.org/10.5281/zenodo.3265342.

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<strong><em>ABSTRACT</em></strong> <strong><em>R</em></strong><em>eview on novel approach in pharmaceutical gel explains about gels and its novel development as hydrogel. Gel which is defined as intermediate state of matter consists of liquid and solid components. Hydrogels are also briefly discussed in the review that is defined as three dimensional structures which has capacity to retain bulk amount of water and also biological fluids to swell. In novel approach in pharmaceutical gel is In-Situ gels. In-situ gels are type of hydrogels that are solution in form and undergo gelation in contact

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Poonam, C. Rahangadale Khushbu O. Biranwar Laxmi D. Chikhlondhe Laxmi Y. Bisen Neha K. Bijewar Punam Y. Yede Manisha U. Mishra. "Formulation And Evaluation Of Fast Guard Joint Pain Relief Herbal Patches." International Journal in Pharmaceutical Sciences 2, no. 6 (2024): 182–1. https://doi.org/10.5281/zenodo.11481456.

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Joint pain is one of the common disorders caused due to various factors like lack of nutrients vitamin and age, general health condition physical weakness, disease, etc. To prepare the transdermal joint relief patch is medicated adhesive patch that is specialist are ongoing to explore for new method that can efficiently and painlessly transmit blood stream. It is a place on a skin to deliver a specific dose of medication through the skin and into the blood stream. The transdermal drug delivery system is a one of the novel drug delivery systems which over comes arises from the conventional dosa

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Deeksha, Jangir, Bhaduka Gaurav, and Agrawal Dilip. "Formulation Development and Optimization of Bi-layer Gastro retentive tablet of Ketorolac Tromethamine." Chemistry Research Journal 9, no. 3 (2024): 42–62. https://doi.org/10.5281/zenodo.11283413.

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<strong>Abstract </strong> Research indicates that pharmaceutical formulations exhibiting effective in vitro floating characteristics tend to endure longer periods in the stomach when tested. Ketorolac tromethamine, a potent NSAID, is administered orally at 10 mg three to four times daily for inflammation and pain relief by inhibiting prostaglandin synthesis. To enhance its gastric residence time and efficacy, a bi-layer gastro retentive tablet was formulated, offering sustained action for 24 hours with improved patient compliance and cost-effectiveness. This systematic approach aimed to optim

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Rajeshwari, Gokul Khairnar, Ramdas Darade Ashwini, and Rajesh Tasgaonkar Rupali. "A review on tablet binders as a pharmaceutical excipient." World Journal of Biology Pharmacy and Health Sciences 17, no. 3 (2024): 295–302. https://doi.org/10.5281/zenodo.11365349.

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The tablet formulation contains binders that increase the inter-particulate bond power inside the tablet. Research and progress of novel accessories remains a priority for potential use as a binder in formulations tablet. Tablet binder or binding agent are the substances that are added either dry or in liquid form during wet granulation to form granules or to promote cohesive compacts for directly compressed tablets. E.g., starch, pregelatinized starch, PEG, sorbitol, and HPMC, etc. Tablet Binder and disintegrants have the opposite used in an oral solid formulation. Binder delay tablet disinte

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Patle, Bharti, Vivek Jain, Shradha Shende, and Prabhat Kumar Jain. "Formulation Development and Evaluation of Sustain Release Gastroretentive Floating Tablets of Prochlorperazine Dimaleate." Journal of Drug Delivery and Therapeutics 9, no. 4-s (2019): 445–50. http://dx.doi.org/10.22270/jddt.v9i4-s.3353.

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Floating drug delivery systems are the gastroretentive forms that precisely control the release rate of target drug to a specific site which facilitate an enormous impact on health care. The purpose of this research was to develop a novel gastro retentive drug delivery system based on direct compression method for sustained delivery of active agent to improve the bioavailability, reduce the number of doses and to increase patient compliance. Gastro retentive floating tablets of Prochlorperazine dimaleate (PCZ) were prepared by direct compression method using altered concentrations of HPMC K4,

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Abhishek, Saini, Pawar Rajat, and Dubey P.K. "A REVIEW ON OCULAR IN SITU GEL." International Journal of Pharmaceutical Sciences and Medicine 7, no. 4 (2022): 18–30. http://dx.doi.org/10.47760/ijpsm.2022.v07i04.002.

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Ophthalmic drug delivery presents major challenges for pharmaceutical and medicinal sciences. New ocular drug delivery forms are various; they included in situ gelling systems, liposome’s, nanoparticles, noisome, nanoemulsions and microemulsions. They are suitable for hydrophilic or lipophilic drugs, have the capacity of targeting a specific site and can be administrated in different routes. With the appropriate excipients, in situ gelling systems are able to increase the precorneal residence time and decrease the loss of drug due to the tear. In situ gelling system is a formulation that is in

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Rama Rao, Tadikonda. "HYDROPHILIC MATRIX TABLETS AS ORAL CONTROLLED DRUG DELIVERY SYSTEMS IN 20TH CENTURY: A REVIEW." International Journal of Advanced Research 12, no. 08 (2024): 1372–93. http://dx.doi.org/10.21474/ijar01/19381.

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Matrix systems are easy to formulate compared to other controlled release dosage forms. The manufacture of matrix tablets involves the direct compression of blend of drug, retardant material and additives to form a tablet in which drug is embedded in a matrix core of the retardant. Alternatively, retardant-drug blends may be granulated prior to compression. Of the three classes of retardant material used to formulate matrix tablets, polymers that form hydrophilic matrices are attracting the attention of pharmaceutical technologists. These polymers include Methyl cellulose (MC), Hydroxy ethyl c

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Kumar, Suraj, and Bishnu Upreti. "Formulation and Evaluation of Gastroretentive Floating Microspheres of Amiloride Hydrochloride." Asian Pacific Journal of Health Sciences 11, no. 3 (2024): 14–24. http://dx.doi.org/10.21276/apjhs.2024.11.3.04.

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Background: Amiloride, a potassium-sparing diuretic, is widely prescribed for the management of hypertension, congestive heart failure, and various renal disorders. However, its low oral bioavailability due to extensive first-pass metabolism and short half-life necessitates frequent dosing, leading to patient inconvenience and compromised therapeutic outcomes. To address these limitations, the development of novel drug delivery systems capable of enhanced gastrointestinal retention of amiloride has garnered significant attention. Among these, gastroretentive microspheres represent a promising

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Allegra, Alessio, Paolo Inglese, Eugenia Guccione, Vittorio Farina, and Giuseppe Sortino. "Calcium Ascorbate Coating Improves Postharvest Quality and Storability of Fresh-Cut Slices of Coscia and Abate Fétel Pears (Pyrus communis L.)." Horticulturae 8, no. 3 (2022): 227. http://dx.doi.org/10.3390/horticulturae8030227.

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Flesh firmness is closely related to fruit ripeness and is typically a reliable indicator of shelf-life potential so it could be considered a crucial quality index for the determination of pear quality. Flesh softening after cutting could considerably affect consumer acceptance of fresh-cut pears (Pyrus communis L.). Indeed, mechanical stress (cutting, peeling, etc.) could lead to ethylene production that results in the hydrolysis of pectic substances in the cell walls. The effectiveness of an edible coating treatment on the physical-chemical, nutraceutical, and sensorial analysis was evaluate

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Radke, Rahul S., Bharat B. Dhore, Ramesh R. Pagore, and Kailash R. Biyani. "Formulation, Development and Evaluation of Pulsatile Tablets of Etoricoxib." Journal of Drug Delivery and Therapeutics 14, no. 11 (2024): 89–94. http://dx.doi.org/10.22270/jddt.v14i11.6890.

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Aim: This research aimed to develop a pulsatile drug delivery system (PDDS) for etoricoxib, selective COX-2 inhibitor analgesic, to address the limitations of conventional formulations by releasing the drug at specific intervals aligned with the circadian rhythm of pain. Method: Core tablets containing Etoricoxib were prepared by direct compression with varied concentrations of croscarmellose sodium as a superdisintegrant. The optimized core tablets were coated using hydrophilic (HPMC K4M) and hydrophobic (ethyl cellulose) polymers in different ratios to create press-coated pulsatile tablets w

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Ujjawal, Ahirwal*, Namdev Nidhi, and Kansare Aman. "FORMULATION AND EVALUATION OF COFFEE AND TURMERIC PEEL-OFF FACE GEL MASK." World Journal of Pharmaceutical Science and Research 3, no. 1 (2024): 70–78. https://doi.org/10.5281/zenodo.10939979.

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Skin care preparations are designed to exert local activity when applied over the skin mucous membrane, these skin preparations include gel, lotion, ointment, cream, peel off mask etc. Peel-Off face mask is one of the cosmetics that is used to treat skin from free radicals. It is designed to address common skin concerns and tightening of skin, moisturizing and tan removal from the skin. The aim of this study was to obtain a peel off gel facial mask preparation containing coffee and turmeric having antioxidants & anti-inflammatory properties. In this study, five formulations containing comb

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Corrie, Leander, Srinivas Ajjarapu, Srikanth Banda, Madhukiran Parvathaneni, Pradeep Kumar Bolla, and Nagavendra Kommineni. "HPMCAS-Based Amorphous Solid Dispersions in Clinic: A Review on Manufacturing Techniques (Hot Melt Extrusion and Spray Drying), Marketed Products and Patents." Materials 16, no. 20 (2023): 6616. http://dx.doi.org/10.3390/ma16206616.

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Today, therapeutic candidates with low solubility have become increasingly common in pharmaceutical research pipelines. Several techniques such as hot melt extrusion, spray drying, supercritical fluid technology, electrospinning, KinetiSol, etc., have been devised to improve either or both the solubility and dissolution to enhance the bioavailability of these active substances belonging to BCS Class II and IV. The principle involved in all these preparation techniques is similar, where the crystal lattice of the drug is disrupted by either the application of heat or dissolving it in a solvent

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Tayal, Shivam, Pradyumn Tiwari, Vinod Sahu, and Shivang Sharma. "Preparation and Characterization of an Antiviral Gel." International Journal of Pharma Professional’s Research (IJPPR) 14, no. 4 (2023): 150–56. http://dx.doi.org/10.48165/ijppronline.2023.14413.

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The study was to develop an antiviral gel for topical application. The topical application of drug has many advantages over the intravenous and oral administration. It prevents metabolism of drug from liver and avoid the risk of gastrointestinal disorder and inconvenience of intravenous therapy pain. When the drug is applied topically it can penetrate deeper into the skin hence show better absorption and bioavailability. The wide varieties of pharmaceutical dosage form are available for topical drug delivery system. The most used one is gel, ointment and cream. Herpes Simplex Virus (HSV) is wi

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Hitesh, N. Jain* Parth P. Patel Millin R. Gohel and Umesh M. Upadhyay. "FORMULATION AND EVALUATION OF PREGABALIN SUSTAINED RELEASE TABLETS." IAJPS,CSK PUBLICATIONS 03, no. 11 (2016): 1316–21. https://doi.org/10.5281/zenodo.179210.

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Objectives: The objective of the present study is to formulate the sustained release matrix tablet of Pregabalin using various matrix polymers which release the drug up to 24 hours. As the dose of Pregabalin is 50mg thrice a day so to reduce the dosage frequency and to increase patient compliance. Experimental Work: The sustained release tablets of Pregabalin were prepared by direct compression method. For this, various polymers like HPMC K4M, Ethocel, Polyox WSR 301 and Polyox WSR 303 were used in various concentrations. The formulations were evaluated for hardness, friability, weight variati

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Babita, Himmatrao More, Pradeep Shirke Vaibahavi, Sanjeev Bhambure Aditya, and Rajesh Tasgaonkar Rupali. "Duocapsule and alternative shell material to gelatin: Advancement in capsule formulation." World Journal of Biology Pharmacy and Health Sciences 13, no. 2 (2023): 221–27. https://doi.org/10.5281/zenodo.8026808.

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Owing to broad advantages like self-medication, unit dosage form, and patient compliance, cost effective, limited interaction with the excipients and possibility of mask the unpleasant taste, capsules are the most extensively recognized conventional solid dosage form after Tablet. In the world of Novel drug delivery system to overcome the disadvantages of conventional delivery system modifications are made in the capsule to develop a product of higher selectivity for medical treatment like the capsules that facilitates the controlled drug delivery, sustained and targeted release profiles with

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Chaudhary, Ritu, Sushant Upadhyaya, and Vikas Kumar Sangal. "A Parametric Study on the HDPE/PP and Marble Slurry Waste Utilisation Using Single Screw Extruder." Asian Journal of Water, Environment and Pollution 18, no. 4 (2021): 9–17. http://dx.doi.org/10.3233/ajw210038.

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Due to the increased socio-economic development, the manufacturing of different products based on various polymers for different applications such as space crafts, airplanes, automobiles, boats, and sports equipment are increasing continuously. This huge increase in solid polymer commodities is also creating the extravagant quantity of solid waste polymers (SWPs) due to their non-degradable characteristics. These SWPs, for example, high-density polyethylene (HDPE), polypropylene (PP), low-density polyethylene (LDPE), and nylon, etc., are used frequently in various applications and create new c

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Nigal, Aparna, Avinash Darekar, and Ravindranath Saudagar. "A Review on Nanohybrids: Technique for Solubility Enhancement of Poorly Water Soluble Drugs." Journal of Drug Delivery and Therapeutics 9, no. 3 (2019): 634–40. http://dx.doi.org/10.22270/jddt.v9i3.2882.

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In order the drug bioavailable in human body must absorb it, and in oral treatments absorption takes place, after drug dissolution by diffusion of the molecules through gastrointestinal membranes. It was found that BCS class –II drug has poor aqueous solubility in GI tract greatly influences the drug release; particularly it affects the bioavailability of drug. Solubilization of water insoluble drug is a big issue of pharmaceutical research. Nanohybrids are combination of two or more different materials with different properties of each and that are fused, by an effort to blend the best proper

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