Relevant bibliographies by topics / HPMC K 100 LVCR

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Academic literature on the topic 'HPMC K 100 LVCR'

Author: Grafiati
Published: 3 June 2025
Last updated: 20 July 2025

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Journal articles on the topic "HPMC K 100 LVCR"

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R., Shyamsunder 1. G. Kalpana 2. K. Bhavanasindhu 3. *. "FORMULATION AND EVALUATION OF ORAL HERBAL TABLETS CONTAINING METHANOLIC EXTRACT OF ALTERNANTHERA PUNGENS WITH CYTOTOXIC ACTIVITY." Journal of Pharma Research 7, no. 4 (2018): 56–62. https://doi.org/10.5281/zenodo.1228682.

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<strong><em>ABSTRACT</em></strong> <strong><em>T</em></strong><em>he purpose of the present study is to prepare methanolic extract of the whole plant Alternanthera pungens (MEAP), to perform phytochemical analysis, screening of cytotoxic activity using MCF-7 cell lines and to develop herbal tablets using various polymers. The methanolic extract was prepared by maceration method and by performing qualitative analysis of extract MEAP, it was found to contain alkaloids, steroidal and triterpenoids and flavonoids.&nbsp; The extract MEAP has exhibited significant cytotoxic activity by performing In
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2

Witowski, Janusz, Andrzej Breborowicz, Nicholas Topley, Leo Martis, Jan Knapowski, and Dimitrios G. Oreopoulos. "Insulin Stimulates the Activity of Na+/K+-Atpase in Human Peritoneal Mesothelial Cells." Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis 17, no. 2 (1997): 186–93. http://dx.doi.org/10.1177/089686089701700215.

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Objective To assess the effect of insulin on the Na+/ K+-ATPase expression and activity in human peritoneal mesothelial cells (HPMC). Methods HPMC were isolated from the omental tissue of non-uremic patients, grown to confluence and rendered quiescent by serum deprivation for 24 hours. The activity of Na+/K+-ATPase was determined by measuring the ouabain-sensitive86Rb uptake. To assess whether the effect of insulin was related to changes in [Na+]i the sodium influx was measured with 22Na and the activity of Na+/K+ -A TPase was assessed in the presence of amiloride. Expression of Na+/K+ -A TPas
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Ramarao, Ch Taraka, J. Vijaya Ratna, and R. B. Srinivasa. "DESIGN AND CHARACTERIZATION OF ALFUZOSIN HCL GASTRORETENTIVE FLOATING MATRIX TABLETS EMPLOYING HPMC K 100M." INDIAN DRUGS 55, no. 11 (2018): 71–73. http://dx.doi.org/10.53879/id.55.11.10741.

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The present investigation involves developing gastro retentive drug delivery systems (GFDDS) of alfuzosin HCl using HPMCK100M a is the matrixing agent and floating enhancer. Sodium bicarbonate in the acidic environment reacts with the acid and produces carbon dioxide. The gastro retentive tablets can be formulated to increase the gastric residence time and thereby increase the oral bioavailability. From the drug release study, it was concluded that the AFTB4 formula of HPMC K 100 M matrix tablets gives the controlled release up to 12 hours by showing increased release with floating lag time 24
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Shaik, Salma, Sudhir Maddela, and Buchi N. Nalluri. "Development of Capecitabine Floating Tablet Dosage Forms for Treating Stomach Cancer." Journal of Drug Delivery and Therapeutics 10, no. 3-s (2020): 199–205. http://dx.doi.org/10.22270/jddt.v10i3-s.4171.

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Objective: In the present research work, oral gastro retentive dosage forms (GRDFs) of capecitabine (CPC) were formulated using floating concept.&#x0D; Methods: GRDFs were formulated using hydroxypropyl methyl cellulose (HPMC K4M and K15M) as drug release retardant, sodium bicarbonate (NaHCO3) and calcium carbonate (CaCO3) as gas generating agents, and micro crystalline cellulose (MCC), dicalcium phosphate (DCP), spray dried lactose (SDL), and pre gelatinized starch (PGS) as fillers. The tablets were prepared by direct compression method and evaluated for various parameters. The GRDFs were als
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Bhumi, Patel* Dr. Chainesh Shah. "FABRICATION AND IN-VITRO CHARACTERIZATION OF TRANSDERMAL MATRIX PATCH OF KETOPROFEN FOR TRANSDERMAL THERAPEUTIC SYSTEM." Indo American Journal of Pharmaceutical Sciences (IAJPS) 03, no. 09 (2016): 960–73. https://doi.org/10.5281/zenodo.153859.

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Objective: The objective of research work was to improve the permeability of Ketoprofen and to provide controlled release of drug to provide maximum effective concentration. Experimental work: Transdermal drug delivery systems are polymeric patches containing dissolved or dispersed drugs that deliver therapeutic agents at a constant rate to the human skin. Matrix type transdermal patches containing Ketoprofen were prepared by solvent casting method employing aluminium foil method. Polyethylene glycol (PEG) 400 was used as plasticizer and Dimethyl sulfoxide (DMSO) was used as penetration enhanc
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Prusty, Amaresh, Sanjit Senapati, and Gyanaranjan Behera. "BOX-BEHNKEN DESIGN APPROACH (BBDA) IN DEVELOPMENT AND OPTIMIZATION OF METFORMIN EXTENDED RELEASE TABLETS (MERT)." Ankara Universitesi Eczacilik Fakultesi Dergisi 49, no. 2 (2025): 11. https://doi.org/10.33483/jfpau.1539651.

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Objective: The present research outlines the use of quality by design (QbD) method to formulate MERT using Box-Behnken Design approach (BBDA). Based on quality target product profile (QTPP) to achieve tablets hardness and % cumulative Drug Release (% CDR) (at 2 hour and 10 hour), Critical quality attribute (CQA)were identified and selected as independent variable. In this present work, HPMC K 100M, Eudragit RL 100, and excipients MCC are selected as independent variables at their high and low levels in development of MERT. Material and Method: As per Design-Expert® prediction, total 19 formula
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Abhishek, Bhosale*1 Priti Shinde2. "Formulation and Evaluation of Metformin HCL Gastroretentive Floating Sustained Released Tablet." International Journal of Scientific Research and Technology 2, no. 6 (2025): 06–16. https://doi.org/10.5281/zenodo.15566055.

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The Metformin HCl Gastroretentive Floating Sustained Release Tablet was formulated using the Wet Granulation method. This tablet incorporates an effervescent system, where Hydroxypropyl Methylcellulose (HPMC) K 100, a swellable polymer, facilitates the floating mechanism. Sodium bicarbonate is employed to create the effervescent system. A synergistic combination of HPMC K 100 and Xanthan Gum enhances the sustained release profile of the formulation. The prepared gastroretentive floating tablets were evaluated for various pharmaceutical parameters, including bulk density, tapped density, angle
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Anepu, Sarada, Lohithasu Duppala, and Soma Sundari M. "FORMULATION DEVELOPMENT, CHARACTERIZATION AND IN- VITRO EVALUATION OF FLOATING MATRIX DOSAGE FORM OF TRAMADOL HYDROCHLORIDE USING VARIOUS POLYMERS." Asian Journal of Pharmaceutical and Clinical Research 10, no. 2 (2017): 281. http://dx.doi.org/10.22159/ajpcr.2017.v10i2.15587.

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Objective: The purpose of present study was to formulate the gastro retentive floating tablets of tramadol hydrochloride for enhancement of the gastric residence time.Methods: The floating tablets were prepared by direct compression method and evaluated for hardness, thickness, and friability of the tablets. The in vitro drug release studies were performed for different formulations and to optimize the best formulae based on the dissolution profiles.Results: Fourier transform infrared spectroscopy and differential scanning calorimetry studies revealed that there was no interaction between tram
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Mohammad Gufran, Mohammad Faizan, Sailesh Kumar Ghatuary, Reena Shende, Prabhat Kumar Jain, and Geeta Parkhe. "Formulation, Development and Evaluation of Bilayer Floating Tablet of Gemfibrozil." Journal of Drug Delivery and Therapeutics 9, no. 4 (2019): 574–78. http://dx.doi.org/10.22270/jddt.v9i4-s.3401.

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Formulation development is an important part of drug design and development. Bioavailability and bioequivalence are totally dependent on formulation development. Now-a-days formulation development is done by following QbD (Quality by Design).The aim of present study is to formulate Gemfibrozil (Gem) sustained release (SR) and immediate release (IR) bilayer tablet by different concentration of Hydroxypropyl methylcellulose (HPMC) and HPMC K 100 M to control the release pattern. The sustained release layer of Gem was prepared by using different grades of HPMC like, HPMC K-15, HPMC K-4 along with
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Azad, A. K., K. Jahan, TS Sathi, R. Sultana4, SA Abbas, and ABMH UddinUddin. "IMPROVEMENT OF DISSOLUTION PROPERTIES OF ALBENDAZOLE FROM DIFFERENT METHODS OF SOLID DISPERSION." Journal of Drug Delivery and Therapeutics 8, no. 5 (2018): 475–80. http://dx.doi.org/10.22270/jddt.v8i5.1942.

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Poor aqueous solubility of drugs results in poor absorption and bioavailability. The objective of Solid dispersion technology is to increase the dissolution properties of highly lipophilic drugs, by using different hydrophilic carriers thereby improving their bioavailability. This technology is useful for enhancing the dissolution, absorption and therapeutic efficacy of drugs in dosage forms. Albendazole is a broad-spectrum antihelminthic agent used for the treatment of a variety of parasitic worm infestations. It is practically insoluble in water but slightly soluble in solvents like chlorofo
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Book chapters on the topic "HPMC K 100 LVCR"

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Sunitha, Ramineni, Praveen Sivadasu, and Raghavendra Kumar Gund. "Statistical Optimization and Evaluation of Extended Release Tablets for Divalproex Sodium." In Current Trends in Drug Discovery, Development and Delivery (CTD4-2022). Royal Society of Chemistry, 2023. http://dx.doi.org/10.1039/9781837671090-00549.

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The purpose of current experimental research is to optimize the quantities of macromolecules such as EudragitL/100-55, HPMC-K-100M for the development of divalproex sodium extended release tablets. Divalproexsodium, an anticonvulsant or epileptic agent. It was used in the effective management of bipolar disorders, Mania, seizures, convulsions, tremors/epilepsy. Divalproex sodium ER tablets were formulated with the help of EudragitL/100-55 and HPMC-K-100M in variable composition and variable amounts as per 32 factorial design technique. They were prepared by direct compression technique. Quantities of polymers required for exhibiting extended release of active agent from tablet were chosen as independent variables, in the similar way time required for drug release were chosen as dependent variables (t10%,t50%,t75%,t90%,). Nine formulations were created in accordance with the plan, formulated, and tested for quality control criteria. It is obvious from the results that all formulations meet the compendial restrictions. In order to estimate the kinetic parameters, data from the dissolution research was effectively suited to kinetic modeling. For the responses, polynomial equations were created and validated. The optimised formulation SOD5, which contains 31.25 milligrams of EudragitL/100-55 and 31.25 milligrams of HPMC-K-100M, exhibits resemblance to the commercial product of f2=85.91 and f1=2.25 (DIVALEX). SOD5 formulation follows zero order, and a non-fickian type release mechanism was discovered (n = 0.645).
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