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Journal articles on the topic 'HPP1 gene'

Author: Grafiati

Published: 4 June 2021

Last updated: 6 February 2022

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1

Ebert, Matthias P. A., Suzanne H. Mooney, Lori Tonnes-Priddy, et al. "Hypermethylation of the TPEF/HPP1 Gene in Primary, Metastatic Colorectal Cancers." Neoplasia 7, no. 8 (2005): 771–78. http://dx.doi.org/10.1593/neo.05235.

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2

Young, J., K. G. Biden, L. A. Simms, et al. "HPP1: A transmembrane protein-encoding gene commonly methylated in colorectal polyps and cancers." Proceedings of the National Academy of Sciences 98, no. 1 (2001): 265–70. http://dx.doi.org/10.1073/pnas.98.1.265.

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3

Ivanauskas, A., J. Hoffmann, L. V. Jonaitis, et al. "Distinct TPEF/HPP1 gene methylation patterns in gastric cancer indicate a field effect in gastric carcinogenesis." Digestive and Liver Disease 40, no. 12 (2008): 920–26. http://dx.doi.org/10.1016/j.dld.2008.05.004.

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4

Scougall, KT, CA Maltin, and JA Shaw. "Tetracycline-regulated secretion of human insulin in a transfected non-endocrine cell line." Journal of Molecular Endocrinology 30, no. 3 (2003): 331–46. http://dx.doi.org/10.1677/jme.0.0300331.

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Long-term constitutive secretion of insulin by implantation of ex vivo transfected cells such as fibroblasts or myoblasts or in situ by intramuscular injection of naked plasmid DNA provides a potential approach to gene therapy for diabetes mellitus. A mechanism for regulating insulin secretion will be necessary to realize the therapeutic potential of this approach. A second obstacle is the inability of non-endocrine host cells to fully process proinsulin. Therefore, alteration of the wild-type cDNA will be necessary to achieve processing of proinsulin by endogenous endoproteases within these c

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Aguilera, A., and H. L. Klein. "Genetic and molecular analysis of recombination events in Saccharomyces cerevisiae occurring in the presence of the hyper-recombination mutation hpr1." Genetics 122, no. 3 (1989): 503–17. http://dx.doi.org/10.1093/genetics/122.3.503.

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Abstract The hyper-recombination mutation hpr1 specifically increases mitotic intrachromatid crossovers, with no effect on other mitotic recombination events such as unequal sister chromatid exchange and plasmid-chromosome recombination, and no effect on meiotic recombination and a lesser effect on intrachromosomal gene conversion. The excision repair RAD1 gene is partially required for the expression on the hpr1 phenotype. The simplest hypothesis to account for some of the hpr1 stimulated recombination events is that a heteroduplex DNA intermediate and localized gene conversion are involved.

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Aguilera, A., and H. L. Klein. "HPR1, a novel yeast gene that prevents intrachromosomal excision recombination, shows carboxy-terminal homology to the Saccharomyces cerevisiae TOP1 gene." Molecular and Cellular Biology 10, no. 4 (1990): 1439–51. http://dx.doi.org/10.1128/mcb.10.4.1439.

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The HPR1 gene has been cloned by complementation of the hyperrecombination phenotype of hpr1-1 strains by using a color assay system. HPR1 is a gene that is in single copy on chromosome IV of Saccharomyces cerevisiae, closely linked to ARO1, and it codes for a putative protein of 752 amino acids (molecular mass, 88 kilodaltons). Computer searches revealed homology (48.8% conserved homology; 24.8% identity) with the S. cerevisiae TOP1 gene in an alpha-helical stretch of 129 amino acids near the carboxy-terminal region of both proteins. The ethyl methanesulfonate-induced hpr1-1 mutation is a sin

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Aguilera, A., and H. L. Klein. "HPR1, a novel yeast gene that prevents intrachromosomal excision recombination, shows carboxy-terminal homology to the Saccharomyces cerevisiae TOP1 gene." Molecular and Cellular Biology 10, no. 4 (1990): 1439–51. http://dx.doi.org/10.1128/mcb.10.4.1439-1451.1990.

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The HPR1 gene has been cloned by complementation of the hyperrecombination phenotype of hpr1-1 strains by using a color assay system. HPR1 is a gene that is in single copy on chromosome IV of Saccharomyces cerevisiae, closely linked to ARO1, and it codes for a putative protein of 752 amino acids (molecular mass, 88 kilodaltons). Computer searches revealed homology (48.8% conserved homology; 24.8% identity) with the S. cerevisiae TOP1 gene in an alpha-helical stretch of 129 amino acids near the carboxy-terminal region of both proteins. The ethyl methanesulfonate-induced hpr1-1 mutation is a sin

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8

Santos-Rosa, H., and A. Aguilera. "Isolation and genetic analysis of extragenic suppressors of the hyper-deletion phenotype of the Saccharomyces cerevisiae hpr1 delta mutation." Genetics 139, no. 1 (1995): 57–66. http://dx.doi.org/10.1093/genetics/139.1.57.

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Abstract The HPR1 gene of Saccharomyces cerevisiae is involved in maintaining low levels of deletions between DNA repeats. To understand how deletions initiate in the absence of the Hpr1 protein and the mechanisms of recombination leading to deletions in S. cerevisiae, we have isolated mutations as suppressors of the hyper-deletion phenotype of the hpr1 delta mutation. The mutations defined five different genes called HRS for hyper-recombination suppression. They suppress the hyper-deletion phenotype of hpr1 delta strains for three direct repeat systems tested. The mutations eliminated the hyp

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9

Kosař, Michal, Lumila Holková, Natálie Březinová Belcredi, and Jaroslava Ehrenbergerová. "HPPD gene expression in relation to vitamin E content in spring barley." Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis 57, no. 4 (2009): 13–18. http://dx.doi.org/10.11118/actaun200957040013.

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The enzyme 4-hydroxyphenylpyruvate dioxygenase (HPPD) has a very important role in the biosynthetic pathway of vitamin E. Its activity influences the final level of tocols in plant tissues. Seven barley cultivars with different vitamin E level were grown under control conditions and activity of HPPD gene was measured four, eight and twelve days after pollination of ear tissues. It was found that activity of HPPD gene corresponded with vitamin E content detected in grains (r = 0.77*). The relationship between the gene activity for HPPD eight and twelve days after pollination and vitamin E conte

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10

Sun, Yi, Yuke Tian, Haifeng Li, Dengwen Zhang, and Qiang Sun. "Antinociceptive Effect of Intrathecal Injection of Genetically Engineered Human Bone Marrow Stem Cells Expressing the Human Proenkephalin Gene in a Rat Model of Bone Cancer Pain." Pain Research and Management 2017 (2017): 1–11. http://dx.doi.org/10.1155/2017/7346103.

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Background. This study aimed to investigate the use of human bone marrow mesenchymal stem cells (hBMSCs) genetically engineered with the human proenkephalin (hPPE) gene to treat bone cancer pain (BCP) in a rat model.Methods. Primary cultured hBMSCs were passaged and modified with hPPE, and the cell suspensions (6 × 106) were then intrathecally injected into a rat model of BCP. Paw mechanical withdrawal threshold (PMWT) was measured before and after BCP. The effects of hPPE gene transfer on hBMSC bioactivity were analyzed in vitro and in vivo.Results. No changes were observed in the surface phe

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11

Zhu, Y., C. L. Peterson, and M. F. Christman. "HPR1 encodes a global positive regulator of transcription in Saccharomyces cerevisiae." Molecular and Cellular Biology 15, no. 3 (1995): 1698–708. http://dx.doi.org/10.1128/mcb.15.3.1698.

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The Hpr1 protein has an unknown function, although it contains a region of homology to DNA topoisomerase I. We have found that hpr1 null mutants are defective in the transcription of many physiologically unrelated genes, including GAL1, HO, ADH1, and SUC2, by using a combination of Northern (RNA) blot analysis, primer extension, and upstream activation sequence-lacZ fusions. Many of the genes positively regulated by HPR1 also require SWI1, SWI2-SNF2, SWI3, SNF5, and SNF6. The transcriptional defect at HO and the CCB::lacZ upstream activation sequence in hpr1 mutants is partially suppressed by

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12

Rodriguez-Martin, Noelia M., Sergio Montserrat-de la Paz, Rocio Toscano, et al. "Hemp (Cannabis sativa L.) Protein Hydrolysates Promote Anti-Inflammatory Response in Primary Human Monocytes." Biomolecules 10, no. 5 (2020): 803. http://dx.doi.org/10.3390/biom10050803.

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Hemp seeds have a wide variety of chemical compounds which present biological activity. Specifically, the focus on proteins and bioactive peptides are increasing as alternative sources of nutraceutical uses. In the literature, hemp protein products (HPPs) have reported antioxidant and anti-inflammatory properties. This study aimed to determine the inflammation-related modulatory effects of HPPs on lipopolysaccharide (LPS)-activated primary human monocytes. CD14+ cells were immunomagnetically isolated from buffy coats and the anti-inflammatory activity of hemp protein isolate (HPI) and hydrolys

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13

Fan, H. Y., and H. L. Klein. "Characterization of mutations that suppress the temperature-sensitive growth of the hpr1 delta mutant of Saccharomyces cerevisiae." Genetics 137, no. 4 (1994): 945–56. http://dx.doi.org/10.1093/genetics/137.4.945.

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Abstract The hpr1 delta 3 mutant of Saccharomyces cerevisiae is temperature-sensitive for growth at 37 degrees and has a 1000-fold increase in deletion of tandem direct repeats. The hyperrecombination phenotype, measured by deletion of a leu2 direct repeat, is partially dependent on the RAD1 and RAD52 gene products, but mutations in these RAD genes do not suppress the temperature-sensitive growth phenotype. Extragenic suppressors of the temperature-sensitive growth have been isolated and characterized. The 14 soh (suppressor of hpr1) mutants recovered represent eight complementation groups, wi

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14

Uemura, Hiroshi, Sunil Pandit, Yoshifumi Jigami, and Rolf Sternglanz. "Mutations in GCR3, a Gene Involved in the Expression of Glycolytic Genes in Saccharomyces cerevisiae, Suppress the Temperature-Sensitive Growth of hpr1 Mutants." Genetics 142, no. 4 (1996): 1095–103. http://dx.doi.org/10.1093/genetics/142.4.1095.

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Abstract To study the functions of DNA topoisomerase I and Hpr1 protein, a suppressor mutant of the temperature-sensitive growth of an hpr1 top1-5ts double mutant was isolated. The isolated triple mutant showed cold-sensitive growth. By complementation of this phenotype, the suppressor gene was cloned. DNA sequencing showed it to be GCR3, a gene involved in the expression of glycolytic genes. Further analysis showed that gcr3 mutations also suppressed the temperature-sensitive growth of hpr1 single mutants. Experiments with gcr3 truncation mutants also suggested a genetic interaction between G

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15

Wight, Patricia A. "Effects of Intron 1 Sequences on Human PLP1 Expression: Implications for PLP1-Related Disorders." ASN Neuro 9, no. 4 (2017): 175909141772058. http://dx.doi.org/10.1177/1759091417720583.

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Alterations in the myelin proteolipid protein gene ( PLP1) may result in rare X-linked disorders in humans such as Pelizaeus–Merzbacher disease and spastic paraplegia type 2. PLP1 expression must be tightly regulated since null mutations, as well as elevated PLP1 copy number, both lead to disease. Previous studies with Plp1-lacZ transgenic mice have demonstrated that mouse Plp1 ( mPlp1) intron 1 DNA (which accounts for slightly more than half of the gene) is required for the mPlp1 promoter to drive significant levels of reporter gene expression in brain. However not much is known about the mec

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16

Gunster, M. J., D. P. Satijn, K. M. Hamer, et al. "Identification and characterization of interactions between the vertebrate polycomb-group protein BMI1 and human homologs of polyhomeotic." Molecular and Cellular Biology 17, no. 4 (1997): 2326–35. http://dx.doi.org/10.1128/mcb.17.4.2326.

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In Drosophila melanogaster, the Polycomb-group (PcG) genes have been identified as repressors of gene expression. They are part of a cellular memory system that is responsible for the stable transmission of gene activity to progeny cells. PcG proteins form a large multimeric, chromatin-associated protein complex, but the identity of its components is largely unknown. Here, we identify two human proteins, HPH1 and HPH2, that are associated with the vertebrate PcG protein BMI1. HPH1 and HPH2 coimmunoprecipitate and cofractionate with each other and with BMI1. They also colocalize with BMI1 in in

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Lecoq, Karine, Manfred Konrad, and Bertrand Daignan-Fornier. "Yeast GMP Kinase Mutants Constitutively Express AMP Biosynthesis Genes by Phenocopying a Hypoxanthine-Guanine Phosphoribosyltransferase Defect." Genetics 156, no. 3 (2000): 953–61. http://dx.doi.org/10.1093/genetics/156.3.953.

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Abstract We have characterized a new locus, BRA3, leading to deregulation of the yeast purine synthesis genes (ADE genes). We show that bra3 mutations are alleles of the GUK1 gene, which encodes GMP kinase. The bra3 mutants have a low GMP kinase activity, excrete purines in the medium, and show vegetative growth defects and resistance to purine base analogs. The bra3 locus also corresponds to the previously described pur5 locus. Several lines of evidence indicate that the decrease in GMP kinase activity in the bra3 mutants results in GMP accumulation and feedback inhibition of hypoxanthine-gua

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18

Tanimizu, Naoki, Atsushi Miyajima, and Keith E. Mostov. "Liver Progenitor Cells Develop Cholangiocyte-Type Epithelial Polarity in Three-dimensional Culture." Molecular Biology of the Cell 18, no. 4 (2007): 1472–79. http://dx.doi.org/10.1091/mbc.e06-09-0848.

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Cholangiocytes are cellular components of the bile duct system of the liver, which originate from hepatoblasts during embryonic liver development. Although several transcription factors and signaling molecules have been implicated in bile duct development, its molecular mechanism has not been studied in detail. Here, we applied a three-dimensional (3D) culture technique to a liver progenitor cell line, HPPL, to establish an in vitro culture system in which HPPL acquire differentiated cholangiocyte characteristics. When HPPL were grown in a gel containing Matrigel, which contains extracellular

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Sawasdikosol, Sansana, Kristin M. Russo, and Steven J. Burakoff. "Hematopoietic progenitor kinase 1 (HPK1) negatively regulates prostaglandin E2–induced fos gene transcription." Blood 101, no. 9 (2003): 3687–89. http://dx.doi.org/10.1182/blood-2002-07-2316.

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Prostaglandin E2 (PGE2) is the predominant eicosanoid product released by macrophages at the site of inflammation. Binding of PGE2 to its cognate 7 transmembrane-spanning G protein–coupled receptors (GPCRs) activates signaling pathways, leading to the synthesis of the Fos transcription factor. Because the Ste20 serine/threonine protein kinase (S/TPK) is a critical signal transducer for the G protein–coupled pheromone receptor in Saccharomyces cerevisiae, we postulated that the PGE2 GPCRs may activate one of the Ste20 mammalian orthologs. We demonstrate here that the catalytic activity of a hem

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20

Sugaya, Ikuko, Tingyu Qu, Kiminobu Sugaya, and George D. Pappas. "Genetically Engineered Human Mesenchymal Stem Cells Produce Met-Enkephalin at Augmented Higher Levels in Vitro." Cell Transplantation 15, no. 3 (2006): 225–30. http://dx.doi.org/10.3727/000000006783981981.

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We have reported that transplantation of adrenal medullary chromaffin cells that release endogenous opioid peptides into pain modulatory regions in the CNS produce significant antinociceptive effects in patients with terminal cancer pain. However, the usefulness of this procedure is minimal because the availability of human adrenal tissue is very limited. Alternative xenogeneic materials, such as porcine and bovine adrenal chromaffin cells present problems of immune rejection and possible pathogenic contamination. In an attempt to develop opioid peptide-producing cells of autologous origin, we

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Zhu, Weiguang, Mark M. MaGbanua, and Frank F. White. "Identification of Two Novelhrp-Associated Genes in the hrp Gene Cluster ofXanthomonas oryzae pv. oryzae." Journal of Bacteriology 182, no. 7 (2000): 1844–53. http://dx.doi.org/10.1128/jb.182.7.1844-1853.2000.

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ABSTRACT We have cloned a hrp gene cluster fromXanthomonas oryzae pv. oryzae. Bacteria with mutations in the hrp region have reduced growth in rice leaves and lose the ability to elicit a hypersensitive response (HR) on the appropriate resistant cultivars of rice and the nonhost plant tomato. A 12,165-bp portion of nucleotide sequence from the presumed left end and extending through the hrpB operon was determined. The region was most similar to hrp genes from Xanthomonas campestris pv. vesicatoria and Ralstonia solanacearum. Two new hrp-associated loci, namedhpa1 and hpa2, were located beyond

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Huertas, Pablo, María L. García-Rubio, Ralf E. Wellinger, Rosa Luna, and Andrés Aguilera. "An hpr1 Point Mutation That Impairs Transcription and mRNP Biogenesis without Increasing Recombination." Molecular and Cellular Biology 26, no. 20 (2006): 7451–65. http://dx.doi.org/10.1128/mcb.00684-06.

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ABSTRACT THO/TREX, a conserved eukaryotic protein complex, is a key player at the interface between transcription and mRNP metabolism. The lack of a functional THO complex impairs transcription, leads to transcription-dependent hyperrecombination, causes mRNA export defects and fast mRNA decay, and retards replication fork progression in a transcription-dependent manner. To get more insight into the interconnection between mRNP biogenesis and genomic instability, we searched for HPR1 mutations that differentially affect gene expression and recombination. We isolated mutants that were barely af

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Wilson, Magdalene O., Kathleen T. Scougall, Jarupa Ratanamart, Elizabeth A. McIntyre, and James A. M. Shaw. "Tetracycline-regulated secretion of human (pro)insulin following plasmid-mediated transfection of human muscle." Journal of Molecular Endocrinology 34, no. 2 (2005): 391–403. http://dx.doi.org/10.1677/jme.1.01646.

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Long-term secretion of insulin by host muscle following transduction with an insulin gene construct offers the potential of gene therapy for diabetes without immunosuppression. Clinical implementation will be dependent on proof of principle in human tissue and a system for safely regulating basal insulin levels. Liposomal co-transfection with a tetracycline-responsive wild type human preproinsulin (pTRE-hppI1) or mutant construct (pTRE-hppI4), in which PC2 and PC3 cleavage sites were altered to form tetrabasic consensus sites for furin, together with pTet-off (coding for a transactivating prot

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Maeda, Hideo, Kazumasa Murata, Nozomi Sakuma та ін. "A rice gene that confers broad-spectrum resistance to β-triketone herbicides". Science 365, № 6451 (2019): 393–96. http://dx.doi.org/10.1126/science.aax0379.

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The genetic variation of rice cultivars provides a resource for further varietal improvement through breeding. Some rice varieties are sensitive to benzobicyclon (BBC), a β-triketone herbicide that inhibits 4-hydroxyphenylpyruvate dioxygenase (HPPD). Here we identify a rice gene, HIS1 (HPPD INHIBITOR SENSITIVE 1), that confers resistance to BBC and other β-triketone herbicides. We show that HIS1 encodes an Fe(II)/2-oxoglutarate–dependent oxygenase that detoxifies β-triketone herbicides by catalyzing their hydroxylation. Genealogy analysis revealed that BBC-sensitive rice variants inherited a d

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Chahal, Parminder S., Mithila Jugulam, and Amit J. Jhala. "Mechanism of atrazine resistance in atrazine- and HPPD inhibitor-resistant Palmer amaranth (Amaranthus palmeri S. Wats.) from Nebraska." Canadian Journal of Plant Science 99, no. 6 (2019): 815–23. http://dx.doi.org/10.1139/cjps-2018-0268.

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Palmer amaranth (Amaranthus palmeri S. Wats.) is one of the most problematic weed species in agronomic crops in the United States. A Palmer amaranth biotype multiple-resistant to atrazine and 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitors was reported in a seed corn production field in Nebraska. Rapid detoxification mediated by cytochrome P450 monooxygenases and increased HPPD gene expression were reported as the mechanisms of mesotrione resistance in atrazine- and HPPD inhibitor-resistant Palmer amaranth biotype from Nebraska; however, the mechanism of atrazine resistance is unknown. T

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Sadowski, Samira Mercedes, Marc Pusztaszeri, Marie-Claude Brulhart-Meynet, et al. "Identification of Differential Transcriptional Patterns in Primary and Secondary Hyperparathyroidism." Journal of Clinical Endocrinology & Metabolism 103, no. 6 (2018): 2189–98. http://dx.doi.org/10.1210/jc.2017-02506.

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Abstract Context Hyperparathyroidism is associated with hypercalcemia and the excess of parathyroid hormone secretion; however, the alterations in molecular pattern of functional genes during parathyroid tumorigenesis have not been unraveled. We aimed at establishing transcriptional patterns of normal and pathological parathyroid glands (PGs) in sporadic primary (HPT1) and secondary hyperparathyroidism (HPT2). Objective To evaluate dynamic alterations in molecular patterns as a function of the type of PG pathology, a comparative transcript analysis was conducted in subgroups of healthy samples

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27

Aguilera, A., and H. L. Klein. "Genetic control of intrachromosomal recombination in Saccharomyces cerevisiae. I. Isolation and genetic characterization of hyper-recombination mutations." Genetics 119, no. 4 (1988): 779–90. http://dx.doi.org/10.1093/genetics/119.4.779.

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Abstract Eight complementation groups have been defined for recessive mutations conferring an increased mitotic intrachromosomal recombination phenotype (hpr genes) in Saccharomyces cerevisiae. Some of the mutations preferentially increase intrachromosomal gene conversion (hpr4, hpr5 and hpr8) between repeated sequences, some increase loss of a marker between duplicated genes (hpr1 and hpr6), and some increase both types of events (hpr2, hpr3 and hpr7). New alleles of the CDC2 and CDC17 genes were recovered among these mutants. The mutants were also characterized for sensitivity to DNA damagin

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Marine, Jean-Christophe, Eric J. Bellefroid, Catherine Bourguignon, et al. "Assignment of the Human ZNF83 (HPF1) Zinc Finger Gene to Chromosome 19q13.3-q13.4." Genomics 21, no. 1 (1994): 285–86. http://dx.doi.org/10.1006/geno.1994.1262.

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Laniado, M. E. "Prostate Cancer Potentially Linked to the HPC1 Gene." JAMA: The Journal of the American Medical Association 279, no. 7 (1998): 507–8. http://dx.doi.org/10.1001/jama.279.7.507.

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Keith, Karen E., Lauren Killip, Panqing He, Graham R. Moran, and Miguel A. Valvano. "Burkholderia cenocepacia C5424 Produces a Pigment with Antioxidant Properties Using a Homogentisate Intermediate." Journal of Bacteriology 189, no. 24 (2007): 9057–65. http://dx.doi.org/10.1128/jb.00436-07.

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ABSTRACT Burkholderia cenocepacia is a gram-negative opportunistic pathogen that belongs to the Burkholderia cepacia complex. B. cenocepacia can survive intracellularly within phagocytic cells, and some epidemic strains produce a brown melanin-like pigment that can scavenge free radicals, resulting in the attenuation of the host cell oxidative burst. In this work, we demonstrate that the brown pigment produced by B. cenocepacia C5424 is synthesized from a homogentisate (HGA) precursor. The disruption of BCAL0207 (hppD) by insertional inactivation resulted in loss of pigmentation. Steady-state

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Levy, Julien G., Rachel Gross, Azucena Mendoza-Herrera, et al. "Lso-HPE1, an Effector of ‘Candidatus Liberibacter solanacearum’, Can Repress Plant Immune Response." Phytopathology® 110, no. 3 (2020): 648–55. http://dx.doi.org/10.1094/phyto-07-19-0252-r.

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‘Candidatus Liberibacter solanacearum’ is a plant pathogen affecting the families Solanaceae and Apiaceae in different parts of the world. ‘Ca. L. solanacearum’ is a Gram-negative, fastidious α-proteobacterium that is vectored by different psyllid species. Plant-pathogenic bacteria are known for interfering with the host physiology or defense mechanisms, often by secreting bacterial effectors. Effector proteins are critical for virulence; therefore, the identification of effectors could help with disease management. In this study, we characterized the Sec-translocon-dependent ‘Ca. L. solanacea

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Carpten, John D., Izabella Makalowska, Christiane M. Robbins, et al. "A 6-Mb High-Resolution Physical and Transcription Map Encompassing the Hereditary Prostate Cancer 1 (HPC1) Region." Genomics 64, no. 1 (2000): 1–14. http://dx.doi.org/10.1006/geno.1999.6051.

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Kaufman, Paul D. "New Partners for HP1 in Transcriptional Gene Silencing." Molecular Cell 41, no. 1 (2011): 1–2. http://dx.doi.org/10.1016/j.molcel.2010.12.021.

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Danzer, J. R. "Mechanisms of HP1-mediated gene silencing in Drosophila." Development 131, no. 15 (2004): 3571–80. http://dx.doi.org/10.1242/dev.01223.

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Satijn, D. P., D. J. Olson, J. van der Vlag, et al. "Interference with the expression of a novel human polycomb protein, hPc2, results in cellular transformation and apoptosis." Molecular and Cellular Biology 17, no. 10 (1997): 6076–86. http://dx.doi.org/10.1128/mcb.17.10.6076.

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Polycomb (Pc) is involved in the stable and heritable repression of homeotic gene activity during Drosophila development. Here, we report the identification of a novel human Pc homolog, hPc2. This gene is more closely related to a Xenopus Pc homolog, XPc, than to a previously described human Pc homolog, CBX2 (hPc1). However, the hPc2 and CBX2/hPc1 proteins colocalize in interphase nuclei of human U-2 OS osteosarcoma cells, suggesting that the proteins are part of a common protein complex. To study the functions of the novel human Pc homolog, we generated a mutant protein, delta hPc2, which lac

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Xu, H., U. J. Kim, T. Schuster, and M. Grunstein. "Identification of a new set of cell cycle-regulatory genes that regulate S-phase transcription of histone genes in Saccharomyces cerevisiae." Molecular and Cellular Biology 12, no. 11 (1992): 5249–59. http://dx.doi.org/10.1128/mcb.12.11.5249.

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Histone mRNA synthesis is tightly regulated to S phase of the yeast Saccharomyces cerevisiae cell cycle as a result of transcriptional and posttranscriptional controls. Moreover, histone gene transcription decreases rapidly if DNA replication is inhibited by hydroxyurea or if cells are arrested in G1 by the mating pheromone alpha-factor. To identify the transcriptional controls responsible for cycle-specific histone mRNA synthesis, we have developed a selection for mutations which disrupt this process. Using this approach, we have isolated five mutants (hpc1, hpc2, hpc3, hpc4, and hpc5) in whi

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Xu, H., U. J. Kim, T. Schuster, and M. Grunstein. "Identification of a new set of cell cycle-regulatory genes that regulate S-phase transcription of histone genes in Saccharomyces cerevisiae." Molecular and Cellular Biology 12, no. 11 (1992): 5249–59. http://dx.doi.org/10.1128/mcb.12.11.5249-5259.1992.

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Histone mRNA synthesis is tightly regulated to S phase of the yeast Saccharomyces cerevisiae cell cycle as a result of transcriptional and posttranscriptional controls. Moreover, histone gene transcription decreases rapidly if DNA replication is inhibited by hydroxyurea or if cells are arrested in G1 by the mating pheromone alpha-factor. To identify the transcriptional controls responsible for cycle-specific histone mRNA synthesis, we have developed a selection for mutations which disrupt this process. Using this approach, we have isolated five mutants (hpc1, hpc2, hpc3, hpc4, and hpc5) in whi

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Carmona-Rivera, C., RA Hess, K. O'Brien, et al. "Novel mutations in the HPS1 gene among Puerto Rican patients." Clinical Genetics 79, no. 6 (2010): 561–67. http://dx.doi.org/10.1111/j.1399-0004.2010.01491.x.

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Norsworthy, Jason K., Vijay K. Varanasi, Muthukumar Bagavathiannan, and Chad Brabham. "Recurrent Selection with Sub-Lethal Doses of Mesotrione Reduces Sensitivity in Amaranthus palmeri." Plants 10, no. 7 (2021): 1293. http://dx.doi.org/10.3390/plants10071293.

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Amaranthus palmeri, ranked as the most prolific and troublesome weed in North America, has evolved resistance to several herbicide sites of action. Repeated use of any one herbicide, especially at lower than recommended doses, can lead to evolution of weed resistance, and, therefore, a better understanding of the process of resistance evolution is essential for the management of A. palmeri and other difficult-to-control weed species. Amaranthus palmeri rapidly developed resistance to 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitors such as mesotrione. The objective of this study was to te

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Kato, Shinya, Tsugumi Aoe, Akie Hamamoto, Hiroshi Takemori, and Toshiya Nishikubo. "New Deletions in the Hermansky-Pudlak Syndrome Type 5 Gene in a Japanese Patient." Reports 2, no. 2 (2019): 15. http://dx.doi.org/10.3390/reports2020015.

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The Hermansky-Pudlak syndrome (HPS) is a rare disease characterized by oculocutaneous albinism and prolonged bleeding. HPS is caused by alterations in HPS1-10 and their related genes, comprising the biogenesis of lysosome-related organelles complex 1–3 and adapter protein 3. Here, we report a Japanese patient with HPS associated with mild hypopigmentation, nystagmus, and impaired visual acuity. Sequencing analyses of the mRNA of this patient revealed new deletions (ΔGA and ΔG) in the HPS5 gene. This was the first case of HPS5 gene deficiency in Japan, and the two above-mentioned deletions have

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Wang, Xiaoling, Yanjie Chang, Yanping Li, Xiaojing Zhang, and David W. Goodrich. "Thoc1/Hpr1/p84 Is Essential for Early Embryonic Development in the Mouse." Molecular and Cellular Biology 26, no. 11 (2006): 4362–67. http://dx.doi.org/10.1128/mcb.02163-05.

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ABSTRACT The yeast TREX complex physically couples elongating RNA polymerase II with RNA processing and nuclear RNA export factors to facilitate regulated gene expression. Hpr1p is an essential component of TREX, and loss of Hpr1p compromises transcriptional elongation, RNA export, and genome stability. Despite these defects, HPR1 is not essential for viability in yeast. A functional orthologue of Hpr1p has been identified in metazoan species and is variously known as Thoc1, Hpr1, or p84. However, the physiological functions of this protein have not been determined. Here, we describe the gener

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Fang, C., L. Schmitz, and P. M. Ferree. "An unusually simple HP1 gene set in Hymenopteran insects." Biochemistry and Cell Biology 93, no. 6 (2015): 596–603. http://dx.doi.org/10.1139/bcb-2015-0046.

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The heterochromatin protein 1 (HP1) gene family includes a set of paralogs in higher eukaryotes that serve fundamental roles in heterochromatin structure and maintenance, and other chromatin-related functions. At least 10 full and 16 partial HP1 genes exist among Drosophila species, with multiple gene gains, losses, and sub-functionalizations within this insect group. An important question is whether this diverse set of HP1 genes and their dynamic evolution represent the standard rule in eukaryotic groups. Here we have begun to address this question by bio-informatically identifying the HP1 fa

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Smallwood, A., P. O. Esteve, S. Pradhan, and M. Carey. "Functional cooperation between HP1 and DNMT1 mediates gene silencing." Genes & Development 21, no. 10 (2007): 1169–78. http://dx.doi.org/10.1101/gad.1536807.

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Jiang, Ping, Aseem Kumar, Joseph E. Parrillo, et al. "Cloning and Characterization of the Human Heparanase-1 (HPR1) Gene Promoter." Journal of Biological Chemistry 277, no. 11 (2002): 8989–98. http://dx.doi.org/10.1074/jbc.m105682200.

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Cuisset, Thomas, Corinne Frere, Jacques Quilici, et al. "Lack of association between the 807 C/T polymorphism of glycoprotein Ia gene and post-treatment platelet reactivity after aspirin and clopidogrel in patients with acute coronary syndrome." Thrombosis and Haemostasis 97, no. 02 (2007): 212–17. http://dx.doi.org/10.1160/th06-10-0583.

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SummaryVariability in platelet response to antiplatelet therapy and its clinical relevance have been well described. However, the underlying mechanisms remain unclear. It was the aim of the present study to assess whether the response to aspirin and clopidogrel may be influenced by the 807 C/T polymorphism of the glycoprotein Ia (GpIa) gene in patients with non-ST elevation acute coronary syndrome (NSTE ACS). Six hundred one NSTE ACS patients were included in our study and were divided into three groups: CC homozygotes, CT heterozygotes ad TT homozygotes. All patients received loading doses of

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Lasserre, Rémi, Céline Cuche, Ronnie Blecher-Gonen, et al. "Release of serine/threonine-phosphorylated adaptors from signaling microclusters down-regulates T cell activation." Journal of Cell Biology 195, no. 5 (2011): 839–53. http://dx.doi.org/10.1083/jcb.201103105.

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Antigen recognition within immunological synapses triggers and sustains T cell activation by nucleating protein microclusters that gather T cell receptors (TCRs), kinases, and adaptors. Dissipation of these microclusters results in signal termination, but how this process is regulated is unclear. In this paper, we reveal that release of the adaptors SLP76 and GADS from signaling microclusters is induced by the serine/threonine protein kinase HPK1 and that phosphorylation of GADS plays a major role in this process. We found that HPK1 was recruited into microclusters and triggered their dissipat

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Jing, Renwei, Xuan Dong, Kailin Li, Jie Yan, Xiangyuan Chen, and Lijun Feng. "The Ap3b1 gene regulates the ocular melanosome biogenesis and tyrosinase distribution differently from the Hps1 gene." Experimental Eye Research 128 (November 2014): 57–66. http://dx.doi.org/10.1016/j.exer.2014.08.010.

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Sood, Raman, Tom I. Bonner, Izabela Makalowska, et al. "Cloning and Characterization of 13 Novel Transcripts and the Human RGS8 Gene from the 1q25 Region Encompassing the Hereditary Prostate Cancer (HPC1) Locus." Genomics 73, no. 2 (2001): 211–22. http://dx.doi.org/10.1006/geno.2001.6500.

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Piruat, José I., Sebastián Chávez, and Andrés Aguilera. "The Yeast HRS1 Gene Is Involved in Positive and Negative Regulation of Transcription and Shows Genetic Characteristics Similar to SIN4 and GAL11." Genetics 147, no. 4 (1997): 1585–94. http://dx.doi.org/10.1093/genetics/147.4.1585.

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Abstract We provide genetic evidence that HRS1/PGD1, a yeast gene previously identified as a suppressor of the hyper-recombination phenotype of hpr1, has positive and negative roles in transcriptional regulation. We have analyzed three differently regulated promoters, GAL1, PHO5 and HSP26, by β-galactosidase assays of lacZ-fused promoters and by Northern analysis of the endogenous genes. Transcription of these promoters was derepressed in hrs1Δ mutants under conditions in which it is normally repressed in wild type, Under induced conditions it was either strongly reduced or significantly enhan

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Nunes, Luiz R., Regina Costa de Oliveira, Daniela Batista Leite, et al. "Transcriptome Analysis of Paracoccidioides brasiliensis Cells Undergoing Mycelium-to-Yeast Transition." Eukaryotic Cell 4, no. 12 (2005): 2115–28. http://dx.doi.org/10.1128/ec.4.12.2115-2128.2005.

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ABSTRACT Paracoccidioides brasiliensis is a thermodimorphic fungus associated with paracoccidioidomycosis (PCM), a systemic mycosis prevalent in South America. In humans, infection starts by inhalation of fungal propagules, which reach the pulmonary epithelium and transform into the yeast parasitic form. Thus, the mycelium-to-yeast transition is of particular interest because conversion to yeast is essential for infection. We have used a P. brasiliensis biochip carrying sequences of 4,692 genes from this fungus to monitor gene expression at several time points of the mycelium-to-yeast morpholo

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