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Journal articles on the topic 'HPTLC analysis'

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Published: 5 June 2025

Last updated: 1 August 2025

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1

Saibaba, S. V., and P. Shanmuga Pandiyan. "High Performance Thin Layer Chromatography: A Mini Review." Volume 2, Issue 4: October 2016 – December 2016 2, no. 4 (2016): 219–26. http://dx.doi.org/10.32463/rphs.2016.v02i04.43.

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High Performance Thin layer Chromatography (HPTLC) technique is a sophisticated and automated form of the thin-layer chromatography (TLC) with better and advanced separation efficiency and detection limits, and is often an excellent alternative to GC and HPLC. Applications of HPTLC include phytochemical and biomedical analysis, herbal drug quantification, active ingredient quantification, fingerprinting of formulations, and check for adulterants in the formulations. HPTLC is useful in detecting chemicals of forensic concern. Various advance techniques in reference to HPTLC like hyphenations in

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2

Edward Raju Gope, Shaik Munnisha Begum, Pujitha Prayer Anisetti, et al. "A Review of Principles, Applications, and Recent Developments in HPTLC and HPLC." Journal of Pharma Insights and Research 2, no. 6 (2024): 056–64. https://doi.org/10.69613/315vge42.

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High-Performance Thin Layer Chromatography (HPTLC) and High-Performance Liquid Chromatography (HPLC) represent fundamental analytical techniques in modern chemical analysis. These sophisticated separation methods have revolutionized the field of analytical chemistry through their precision, reliability, and versatility. HPTLC, an enhancement of traditional thin-layer chromatography, offers advantages such as minimal sample preparation, simultaneous analysis of multiple samples, and cost-effectiveness. It has found extensive applications in pharmaceutical analysis, natural product research, and

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3

Gray, Dean E., Dale Messer, Andrew Porter, et al. "Analysis of Flavonol Aglycones and Terpenelactones in Ginkgo biloba Extract: A Comparison of High-Performance Thin-Layer Chromatography and Column High-Performance Liquid Chromatography." Journal of AOAC INTERNATIONAL 90, no. 5 (2007): 1203–9. http://dx.doi.org/10.1093/jaoac/90.5.1203.

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Abstract Advancements in automated high-performance thin-layer chromatography (HPTLC) have made it feasible to assess its use for the quantitative analysis of marker compounds in botanical preparations. We report here the findings of method comparisons for the terpenelactones and flavonol aglycones by column high-performance liquid chromatography (HPLC) with evaporative light scattering and UV detection, and HPTLC with a scanning densitometer. For the HPTLC assay of terpenelactones, total bilobalide, ginkgolide A, and ginkgolide B consistently achieved &lt;70 of the total determined using

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4

Syeda, Rana Nikhat* Prof A.Ravinder Nath V.Rajesh Babu. "EXTRACTION AND CHARACTERIZATION OF 4- HYDROXYISOLEUCINE FROM TRIGONELLA FOENUM GRAECUM SEEDS." Indo American Journal of Pharmaceutical Sciences 04, no. 06 (2017): 1711–16. https://doi.org/10.5281/zenodo.822436.

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The objective of the present investigation is to extract, quantify and characterize the active constituent, 4- hydroxyisoleucine in Trigonella foenum graecum seeds using HPLC and HPTLC methods. Aqueous extract of crushed seeds of Trigonella foenum graecum was prepared and subjected to HPLC and HPTLC analysis. HPLC analysis was performed using C18 reverse phase column and Fluorescence detector with an elution gradient composed of 65 mmol Sodium acetate, l.5% tetrahydrofurane (pH 5.7) and methanol. HPTLC analysis was performed using semiautomatic TLC sampler Linomat V (CAMAG) controlled by WinCA

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B, Gunjal Sanket, and Dighe P. R. "Analysis of Herbal Drugs by HPTLC: A REVIEW." Asian Journal of Pharmaceutical Research and Development 10, no. 2 (2022): 125–28. http://dx.doi.org/10.22270/ajprd.v10i2.1056.

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Densitometric evaluation through HPTLC is very useful method for standardization of medicinal plants and other natural products, especially those used in different system of medicine. It has been approved as an authenticated method of analysis in several pharmacopeias, including the USP and the IP. Result from a number of medicinal plants studied in the laboratory have shown that, TLC- densitometry is more advantageous strategy than HPLC or GLC. Improvement in resolution, HPTLC is valuable tool for the investigation of herbal products with respect to different aspects of their quality. sensiti

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Fecka, Izabela, Adam Kowalczyk, and Wojciech Cisowski. "Phenolic Acids and Depsides from Some Species of the Erodium Genera." Zeitschrift für Naturforschung C 56, no. 11-12 (2001): 943–50. http://dx.doi.org/10.1515/znc-2001-11-1205.

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Abstract Six natural polyphenolic compounds, brevifolin carboxylic acid, brevifolin, ellagic acid, methyl gallate, gallic acid and protocatechuic acid have been isolated from the methanol extract of the whole plant of Erodium cicutarium (L.) L.’Herit. (Geraniaceae). Structures were determined by conventional methods of analysis and confirmed by MS and NMR spectral analysis. The distribution of these compounds in the other species of the Erodium genera (E. botrys, E. chium, E. ciconium, E. cicutarium, E. glutinosum subsp. dunense, E. gruinum, E. manescavi, E. pelargoniiflorum, E. petraeum ) wer

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7

K., Nagaraju, Mekala Sunil, Anusha M., Gopaiah Kurra Venkata, and Subbarao G. "Carvedilol, Tablets Assay Method Development and Validation by UV Spectroscopy, RP-HPLC and HPTLC." Trends in Pharmaceuticals and Nanotechnology (e-ISSN: 2582-4457) 2, no. 1 (2020): 37–47. https://doi.org/10.5281/zenodo.3632225.

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<em>Aim & Objectives : </em><em>The present study describes the development of a new rapid, simple, sensitive and reproducible RP-HPLC, HPTLC, UV Spectrophotometry method for the analysis of Carvedilol that offer certain advantages in its simplicity and sensitivity and applicable in routine analysis. Material & Methods: Carvedilol is polar in nature, reverse phase chromatography has been used and assay method is developed for UV-Spectroscopy, RP-HPLC, & HPTLC   & method validation is also done. Results & Discussion: The validated method was applied for the analysi

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8

Jug, Urška, Vesna Glavnik, Eva Kranjc, and Irena Vovk. "HPTLC–densitometric and HPTLC–MS methods for analysis of flavonoids." Journal of Liquid Chromatography & Related Technologies 41, no. 6 (2018): 329–41. http://dx.doi.org/10.1080/10826076.2018.1448690.

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9

Hussain, Muzammil, Kiran Aftab, Munawar Iqbal, et al. "Determination of Pesticide Residue in Brinjal Sample Using HPTLC and Developing a Cost-Effective Method Alternative to HPLC." Journal of Chemistry 2020 (September 18, 2020): 1–12. http://dx.doi.org/10.1155/2020/8180320.

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Two analytical techniques HPLC (high performance liquid chromatography) and HPTLC (high performance thin layer chromatography) were validated to reveal the quality and quantity of pesticide residues (organophosphorus, organochlorine, and pyrethroids) in brinjal samples collected from a local market of Faisalabad. The HPTLC methods showed linear behavior for standard samples and residue was in the range of 1–130 ng. The organochlorine (α-endosulfan) contaminates the samples at 4, 5, 9, and 10 weeks, and detected quantity was less than MRL (minimum residue level) of the FAO (Food and Agriculture

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10

Wulandari, Lestyo. "EVALUATION OF RE-USED HPTLC PLATE FOR QUALITATIVE AND QUANTITATIVE ANALYSIS." Indonesian Journal of Chemistry 6, no. 3 (2010): 338–40. http://dx.doi.org/10.22146/ijc.21743.

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The eficiency chromatography of HPTLC plate is better than conventional TLC plate but it more expensive. Due to the higher price of HPTLC plate compare to conventional TLC plate, the application of ";re-used"; HPTLC plate has been tested. After being used for analyzing samples, the plates were developed again with the mobile phase, then dried for 60 min before using for the next measurement. The qualitative chromatography profile showed that ";re-used"; HPTLC plate has less contaminant than new HPTLC plate and the RSD of the precision quantitative testing of the plates reused three times showe

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11

Szaufer-Hajdrych, M., W. Bylka, I. MatłAwska, M. Wójciak-Kosior, G. Matysik, and J. Jodynis-Liebert. "Densitometric HPTLC and HPLC analysis of phenolic acids fromAquilegia vulgaris." Acta Chromatographica 20, no. 4 (2008): 685–95. http://dx.doi.org/10.1556/achrom.20.2008.4.13.

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12

Degroodt, Jean-Marie, Brigitte Wyhowski Bukanski, Jules Groof, and Hedwig Beernaert. "Cimaterol and clenbuterol residue analysis by HPLC-HPTLC in liver." Zeitschrift f�r Lebensmittel-Untersuchung und -Forschung 192, no. 5 (1991): 430–32. http://dx.doi.org/10.1007/bf01193142.

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13

Jain, Anushi, Ambika Joshi, and Nitesh Joshi. "Allelopathic Potential and HPTLC Analysis of Ipomoea carnea." International Journal of Life-Sciences Scientific Research 3, no. 5 (2017): 1278–82. http://dx.doi.org/10.21276/ijlssr.2017.3.5.2.

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14

Kapase, Sachin N. "ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF COMBINATION OF ANTI-ASTHMATIC DRUGS MONTELUKAST AND DOXOFYLLINE." Journal of Medical pharmaceutical and allied sciences 11, no. 6 (2021): 86–91. http://dx.doi.org/10.22270/jmpas.v10i6.1940.

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For qualitative and quantitative analysis, various analytical techniques are available such as Ultraviolet (UV) Spectrophotometry, High-performance liquid chromatography (HPLC), High-performance thin layer chromatography (HPTLC). As per literature survey, there are some UV, HPLC, Ultra-Performance Liquid Chromatography (UPLC) and HPTLC analytical methods are developed for Montelukast and Doxofylline individually and in a combination with other drugs too, since yet there are no significant stability studies indicating HPLC method reported for Montelukast and Doxofylline combinations. In the cur

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15

Klaus, R. "Quantitative HPTLC analysis — Industrial applications." Chromatographia 20, no. 4 (1985): 235–38. http://dx.doi.org/10.1007/bf02259694.

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16

Sherma, Joseph. "Review of HPTLC in Drug Analysis: 1996-2009." Journal of AOAC INTERNATIONAL 93, no. 3 (2010): 754–64. http://dx.doi.org/10.1093/jaoac/93.3.754.

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Abstract Analytical methods for drug substances, formulations, and clinical samples developed and validated on HPTLC plates during the period 19962009 are reviewed. Procedures, materials, and instrumentation for the different steps in the HPTLC procedure and validation of results; applications to bulk drugs, formulations, stability studies, biological samples (e.g., urine and plasma), and hydrophobicity studies; and prospects for the use of HPTLC for drug analysis in the future are described.

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17

Kalyani, Ashok Patil*1 Shailesh B. Patil2. "To Develop And Validate Stability Indicating Assay Of Diloxanide Furoate By Using UV And HPLC And HPTLC Method For Pharmaceutical Dosage Form." International Journal in Pharmaceutical Sciences 2, no. 6 (2024): 498–517. https://doi.org/10.5281/zenodo.11543189.

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The study aimed to establish stability assays for Diloxanide Furoate using both High-Performance Liquid Chromatography (HPLC) and High-Performance Thin-Layer Chromatography (HPTLC) methods, covering crucial aspects of method development and validation. Detailed specifications were provided for the HPLC and HPTLC systems to ensure proper setup and functioning. Chromatographic conditions were optimized, including parameters like stationary phase, mobile phase composition, flow rate, and detection wavelength, to achieve optimal separation and detection of Diloxanide Furoate. The identity of pure

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18

S, Thangadurai, B. Sithi Asma, A. Palanimurugan, and A. Cyril. "A Forensic Appraisal of Neoteric Hyphenated Techniques for Separation and Detection of Narcotic Drugs." International Journal of Forensic Sciences 10, no. 1 (2025): 1–17. https://doi.org/10.23880/ijfsc-16000430.

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Narcotic drugs are traditionally been identified on basis of chromatographic-hyphenated techniques in instrumental analysis. Nowadays, contemporary neoteric chromatographic hyphenated techniques have received ever-increasing attention because the principal means to unravel complex analytical problems. A legal examination is a term articulated for examination of all sorts of violations that leads to the prove for any sort of wrong doing as a conclusion of the suspect. Forensic laboratories drugs are identified and separated by TLC, HPLC, HPTLC, GC, LC and known hyphenated techniques which are l

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19

Barakaeva, Dildora, Nuritdin Mukarramov, Anarbay Babekov, Lola Zhamolova, and Maksatbek Turatbekov. "Qualitative and quantitative determination of ferulic acid by HPTLC and HPLC methods in root resin of Ferula Tadshikorum." E3S Web of Conferences 537 (2024): 05021. http://dx.doi.org/10.1051/e3sconf/202453705021.

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Fast, simple, accurate, specific and reliable methods of HPTLC and HPLC have been developed and proposed, which can be used for the analysis of ferulic acid in plant extracts. The HPTLC method is economical because it uses a very small number of mobile phases that effectively dissolve ferulic acid, and the sample purification procedure associated with it is minimal. The developed methods can be widely used to determine the quality of Ferula tadshikorum resin and formulations containing it.

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20

Wójciak-Kosior, Magdalena, Agnieszka Skalska, Grażyna Matysik, and Magdalena Kryska. "Quantitative Analysis of Phenobarbital in Dosage Form by Thin-Layer Chromatography Combined with Densitometry." Journal of AOAC INTERNATIONAL 89, no. 4 (2006): 995–98. http://dx.doi.org/10.1093/jaoac/89.4.995.

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Abstract In this paper, a high-performance thin-layer chromatography (HPTLC) method combined with densitometry has been described. Chromatography was performed on silica gel Si 60F254 plates using dichloromethaneethyl acetateformic acid (9.5 + 0.5 + 0.1, v/v) mobile phase. This method has been successfully applied for the determination of phenobarbital in pharmaceuticals. Obtained results were comparable with traditionally used column high-performance liquid chromatography (HPLC) methods. For the proposed procedure, linearity (r &gt; 0.999), sensitivity (limit of detection 0.4 g/spot), rec

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21

Alqarni, Mohammed H., Faiyaz Shakeel, Tariq M. Aljarba, et al. "Determination of Colchicine in Pharmaceutical Formulations, Traditional Extracts, and Ultrasonication-Based Extracts of Colchicum autumnale Pleniflorum (L.) Using Regular and Greener HPTLC Approaches: A Comparative Evaluation of Validation Parameters." Plants 11, no. 13 (2022): 1767. http://dx.doi.org/10.3390/plants11131767.

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In the literature, there is a scarcity of greener analytical approaches for colchicine (CLH) analysis. As a result, efforts were made in this study to develop and validate a greener reversed-phase high-performance thin-layer chromatography (HPTLC) technique for CLH analysis in traditional extracts (TE) and ultrasonication-based extracts (UBE) of commercial Unani formulations, commercial allopathic formulations, and Colchicum autumnale Pleniflorum (L.) obtained from Egypt and India. This new technique was compared to the regular normal-phase HPTLC method. The greenness profile of both methods w

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22

Degroodt, Jean-Marie, Brigitte Wyhowski Bukanski, Hedwig Beernaert, and Dirk Courtheyn. "Clenbuterol residue analysis by HPLC-HPTLC in urine and animal tissues." Zeitschrift f�r Lebensmittel-Untersuchung und -Forschung 189, no. 2 (1989): 128–31. http://dx.doi.org/10.1007/bf01332946.

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23

Alam, Prawez, Essam Ezzeldin, Muzaffar Iqbal, et al. "Determination of Delafloxacin in Pharmaceutical Formulations Using a Green RP-HPTLC and NP-HPTLC Methods: A Comparative Study." Antibiotics 9, no. 6 (2020): 359. http://dx.doi.org/10.3390/antibiotics9060359.

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In this work; delafloxacin (DLFX) was determined using a validated green RP-HPTLC and NP-HPTLC methods in commercial tablets and in-house developed solid lipid nanoparticles (SLNs). RP-HPTLC determination of DLFX was performed using “RP-18 silica gel 60 F254S HPTLC plates”. However; NP-HPTLC estimation of DLFX was performed using “silica gel 60 F254S HPTLC plates”. For a green RP-HPTLC method; the ternary combination of ethanol:water:ammonia solution (5:4:2 v/v/v) was used as green mobile phase. However; for NP-HPTLC method; the ternary mixture of ethyl acetate: methanol: ammonia solution (5:4

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Erum, Aasiy Ul, Amjad Waheed Yousuf, and Mohd Aslam. "High performance thin layer chromatography analysis of seed extracts of Tudri Surkh (Cheiranthus cheiri)." International Journal of Research in Medical Sciences 11, no. 1 (2022): 139. http://dx.doi.org/10.18203/2320-6012.ijrms20223626.

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Background: To develop the high-performance thin layer chromatography (HPTLC) finger print profile of hydroalcoholic and ethylalcohol extracts of seeds of Tudri Surkh (Cheiranthus cheiri). Methods: Chromatographic technique was used for separation of components from hydroalcoholic and ethylalcohol extracts of seeds and HPTLC was carried out using CAMAG HPTLC system equipped with Linomat V applicator, and WinCATS software.Results: HPTLC profiling of the extract confirm the presence of various phytochemicals. At 640 nm HPTLC finger print of hydroalcoholic extract revealed 16 components with Rf=0

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Narasimhaji, Cheemalapati Venkata, Gokul Marimuthu, Ajay K. Meena, et al. "Marker-based HPTLC profiling and HPLC method for estimating Guggulsterone-Z in Commiphora wightii (Arn.) Bhandari resin and polyherbal Ayurveda formulation (PHAF)." Journal of Drug Research in Ayurvedic Sciences 10, no. 1 (2025): 48–55. https://doi.org/10.4103/jdras.jdras_50_24.

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Abstract BACKGROUND: The Indian herbal medicine system Ayurveda has a rich history associated with use of gum Guggulu (Commiphora wightii (Arn.) Bhandari; CM) for its therapeutic properties. In the present study, CM resin and Guggulu-based polyherbal Ayurvedic formulation (PHAF; having Guggulu as one of the major components) were evaluated for the estimation of Guggulsterone-Z (GZ) using high-performance planar and liquid chromatography techniques. METHODS: In HPTLC analysis, the identification of GZ was carried out in the CM and PHAF extract using a silica gel-coated aluminum plate as the sta

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26

Ghante, M. R., S. D. Sawant, M. Undre, S. G. Jagtap, P. Kulkarni, and V. S. Nikam. "RP-HPLC AND HPTLC METHOD DEVELOPMENT AND VALIDATION FOR ESTIMATION OF DOLUTEGRAVIR IN BULK AND TABLET DOSAGE FORM." INDIAN DRUGS 56, no. 05 (2019): 30–38. http://dx.doi.org/10.53879/id.56.05.11288.

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Dolutegravir (DTG) is a second-generation integrase strand transfer inhibitor (INSTI), antiretroviral drug. RP-HPLC and HPTLC methods have been developed and validated for DTG in bulk and tablet dosage form. In HPLC method, analysis was carried out on C-18 column using a mixture of acetonitrile: phosphate buffer (pH 7.0) in the ratio of (90:10 V/V) as mobile phase at the flow rate 1 mL/min at 261 nm. The method was found to be linear in the concentration range 10-70 μg/mL. Peak for DTG was observed at 2.8 ± 0.1 minutes. For HPTLC method proper resolution was achieved with toluene: methanol: fo

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Narwade, Shital, Hemalata Wadkar, Aishwarya Ghanawat, and Krutika Nilwani. "A Comprehensive Review on HPTLC Method Development." International Journal of Research and Review 12, no. 2 (2025): 71–83. https://doi.org/10.52403/ijrr.20250209.

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High-Performance Thin-Layer Chromatography (HPTLC) is a widely utilized analytical technique that offers significant advantages in the qualitative and quantitative analysis of a variety of chemical substances. This review aims to provide a comprehensive overview of HPTLC method development, focusing on its principles, instrumentation, key parameters, and applications. The paper discusses the critical steps involved in HPTLC method development, including selection of stationary phases, mobile phases, detection methods, and optimization of experimental conditions to achieve high resolution, sens

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Shahi, Shilpa, and Rajani Athawale. "Quantitative HPTLC analysis of palmitoyl hexapeptide." Journal of Planar Chromatography – Modern TLC 23, no. 5 (2010): 365–68. http://dx.doi.org/10.1556/jpc.23.2010.5.12.

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Rumalla, Chidananda, Bharathi Avula, Zulfiqar Ali, et al. "Quantitative HPTLC analysis of phenylpropanoids inRhodiolaspecies." Journal of Planar Chromatography – Modern TLC 24, no. 2 (2011): 116–20. http://dx.doi.org/10.1556/jpc.24.2011.2.6.

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Patil, Vikas Prakash, and Preeti Khulb. "Isolation and Identification of Bioactive Chlorogenic Acid from Ethanol Fraction of Cordia subcordata: HPLC, HPTLC, FTIR, and LC-MS Analysis." INTERNATIONAL JOURNAL OF PHARMACEUTICAL QUALITY ASSURANCE 15, no. 03 (2024): 1144–50. http://dx.doi.org/10.25258/ijpqa.15.3.07.

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Cordia subcordata was subjected for soxhlet extraction using soxhlet apparatus by hydroalcoholic solvent (Ethanol:water; 70:30). The obtained crude extract was subjected to organoleptic properties. The extract was dark greenish or greenish-black in color. The odor of the extract was strong like tamarind. The extract taste was bitter mixed with pungent and the texture was sticky solid. The yield of the extract was 9.1%. It was observed that crude extract contains carbohydrates, reducing sugars, monosaccharides, proteins, amino acids, fats and oil, steroids, cardiac glycosides, saponin glycoside

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Saad, Javed Shaikh*, and Daunde Swapnil. "A REVIEW ON METHOD DEVELOPMENT AND VALIDATION OF STABILITY INDICATING UV METHOD FOR VILDAGLIPTIN." World Journal of Pharmaceutical Science and Research 4, no. 2 (2025): 899–909. https://doi.org/10.5281/zenodo.15302742.

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The present study describes the development of a new rapid, simple, sensitive and reproducible UV Spectrophotometry RP-HPLC, HPTLC method for the analysis of Vildagliptin that offer certain advantages in its simplicity and sensitivity and applicable in routine analysis. Vildagliptin is an antidiabetic agent, belongs to the dipeptidyl peptidase IV (DPP-4) inhibitors. The method employs measurement of absorbance at the wavelength of maximum absorptions of vildagliptin using water as a solven. In order to develop a RP-HPLC, HPTLC, UV effective most of the effect should be spent in method developm

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Chawla, Pooja A., Shailendra Pandey, and ,. Monika. "Various analytical methods for analysis of atorvastatin: A review." Journal of Drug Delivery and Therapeutics 9, no. 3-s (2019): 885–99. http://dx.doi.org/10.22270/jddt.v9i3-s.3004.

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Hyperlipidemia is produced due to abnormal elevated level of lipids in the blood and is a major risk factor for many heart diseases such as atherosclerosis and stroke. Lipids have been implicated in the development of atherosclerosis in humans. In hyperlipidemia there are increased levels of both LDL and triglycerides. Treatment of hyperlipidemia with statins has become an integral part of management of vascular diseases. Statins are the first line therapy for lowering lipid levels. Among statins atorvastatin is the most effective and currently available antihyperlipidemic drug. An enzyme 3-hy

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Hossain, M. Amzad, and Zhari Ismail. "HIGH PERFORMANCE THIN LAYER CHROMATOGRAPHIC DETERMINATION OF CAFFEIC ACID AND ROSMARINIC ACID FROM THE LEAVES OF Orthosiphon stamineus." Indonesian Journal of Chemistry 9, no. 1 (2010): 137–41. http://dx.doi.org/10.22146/ijc.21575.

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This paper presents the studies performed on extraction of Orthosiphon stamineus, Benth by using different solvent for the identification and quantification of the caffeic acid derivatives such as caffeic acid and rosmarinic acid which confers to the leaves of this plant with remarkable pharmaceutical properties. High performance thin-layer chromatographic (HPTLC) allows the identification and the quantification of more than 20 samples in the same chromatographic run. The analysis of the samples requires 15-30 min compared with more than 2 h using a typical HPLC method. Using the techniques of

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Tadikonda, Rama Rao, and Bhagyalakshmi Dasam. "Various Analytical Methods for Analysis of Sitagliptin – A Review." International Journal of Current Science Research and Review 07, no. 08 (2024): 6674–80. https://doi.org/10.5281/zenodo.13358338.

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Abstract : Sitagliptin is a dipeptidyl- peptidase inhibitor used to treat high blood sugar levels caused by type2 diabetes. Absorption of Sitagliptin is 87% orally bioavailable and taking it with or without food does not affect its pharmacokinetics. Sitagliptin reaches maximum plasma concentration in 2 hours. Now in this present analytical research world quality by design or design by expert technique is used to get improved method for method validation. This concise review work can guide an analyst to choose most appropriate method for a best analytical method development and validation. This

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Bezruk, Ivan, Alla Kotvitska, Iuliia Korzh, et al. "Combined Approach to the Choice of Chromatographic Methods for Routine Determination of Hederacoside C in Ivy Leaf Extracts, Capsules, and Syrup." Scientia Pharmaceutica 88, no. 2 (2020): 24. http://dx.doi.org/10.3390/scipharm88020024.

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Developed methods for routine analysis of medicines should be considered in terms of analytical efficiency, economic cost, as well as their environmental impact. Different chromatographic methods for the routine quantitative analysis of hederacoside C in ivy leaf extract and its original dosage forms (capsules and syrup) are developed. The performance of HPLC and UPLC methods should be done using ACE C18 (150 mm × 4.6 mm, 5.0 μm) and ACQUITY UPLC BEH C18 (50 mm × 2.1 mm, 1.7 μm) columns, respectively, and both of them require a mixture of water and acetonitrile in the ratio 71/29 as a mobile p

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Abraham, Aji, Sarala Samuel, and Lizzy Mathew. "Phytochemical analysis of Pathyashadangam kwath and its standardization by HPLC and HPTLC." Journal of Ayurveda and Integrative Medicine 11, no. 2 (2020): 153–58. http://dx.doi.org/10.1016/j.jaim.2017.10.011.

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Sagar, Uttam Kumbhar*, and Dounde Swapnil. "A REVIEW ON METHOD DEVELOPMENT AND VALIDATION OF STABILITY INDICATING UV METHOD FOR CARVEDILOL." World Journal of Pharmaceutical Science and Research 4, no. 2 (2025): 748–57. https://doi.org/10.5281/zenodo.15274436.

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The present study describes the development of a new rapid, simple, sensitive and reproducible UV Spectrophotometry RP-HPLC, HPTLC method for the analysis of Carvedilol that offer certain advantages in its simplicity and sensitivity and applicable in routine analysis. It also describes the development of validation work as per ICH guidelines recommended by the Food and Drug Administration (FDA) of the United States. In order to develop a RP-HPLC, HPTLC, UV effective most of the effect should be spent in method development and optimization as this will improve the final method performance. A we

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Sutar, R. C., and D. S. Musmade. "FINGER PRINTING ANALYSIS OF THE PHENOLS FROM HOLOPTELEA INTEGRIFOLIA (ROXB.) PLANT LEAVES USING HPTLC." INDIAN DRUGS 54, no. 09 (2017): 67–71. http://dx.doi.org/10.53879/id.54.09.10727.

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The present study was conducted to identify the phenols from methanol extracts (MHI) of medicinally and economically useful leaves of Holoptelea integrifolia (Roxb.) plant using High Performance Thin Layer Chromatography (HPLC) technique. Preliminary phytochemical screening was done and HPTLC studies were carried out on CAMAG HPTLC system equipped with Linomat V applicator (Switzerland). Densitometric scanning was performed with Camag TLC scanner IV in the reflectance absorbance mode at 540 nm and operated by Win CATS software (1.4.6 Camag) with the help of tungsten lamp. Preliminary phytochem

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K., Hari Ramakrishnan, and Janaky Ranjithkumar. "Quantitative Determination of Vitamin E Isomers using Gas Chromatography, High Performance Liquid Chromatography and High Performance Thin Layer Chromatography." Indian Journal of Nutrition and Dietetics 54, no. 3 (2017): 294. http://dx.doi.org/10.21048/ijnd.2017.54.3.15589.

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Vitamin E, the fat soluble vitamin is present naturally in some foods and added in food supplements, nutraceuticals etc due to its vital biological function as an antioxidant. Various methods are available for the analysis of vitamin E. Especially High Performance Liquid Chromatography (HPLC) and Gas Chromatography (GC) are exclusively used for the quantitative evaluation of vitamin E, which has also identified the four different isomeric forms of this vitamin. The rate of losses of this vitamin during food processing and analysis, in addition to their transient dynamics, presents complexities

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Bollepaka, Srilatha Santhosh Illendula. "STABILITY INDICATING METHOD DEVELOPMENT OF RIMONABANT AND IT's VALIDATION BY RP-HPLC AND HPTLC METHOD." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 06 (2018): 5602–10. https://doi.org/10.5281/zenodo.1297120.

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A new simple, accurate, rapid, precise, reproducible and cost effective HPLC and HPTLC method for the quantitative estimation of Rimonabant in bulk and pharmaceutical dosage form. In Method using HPTLC, chromatograms were developed in a mobile phase of 2 mM Sodium dihydrogen orthophosphate (NaH2PO4)-Acetonitrile (38:62) for approximately 25 mins and detected at λmax of 303 nm. Accuracy was found to be in the range of 98.31-102.25 % whereas intraday precision was found to be in the range of 0.03 to 1.60%. Interday precision was found to be 1.36, 0.74 and 0.31 at LQC, MQC and HQC, respect

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Chaudhari, Kamlesh Raju, Rajveer Bhaskar, Monika Ola, Amod Patil, Ankita Ambatkar, and Tejaswini Mahajan. "Comprehensive Review on Analytical Profile of Antidepressant Drug." Journal of Drug Delivery and Therapeutics 10, no. 2 (2020): 220–28. http://dx.doi.org/10.22270/jddt.v10i2.3990.

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Venlafaxine is an antidepressant belonging to a group of drugs called selective serotonin and norepinephrine reuptake inhibitors (SSNRIs). Venlafaxine affects chemicals in the brain that may be unbalanced in people with depression. It is used to treat major depressive disorder, anxiety and panic disorder. The present review assesses the various approaches for analysis of Venlafaxine in bulk drug as well as various formulations. A concise review represents the compilation and discussion of about more than 35 analytical methods which includes HPLC, HPTLC, UPLC, LC-MS and UV-Spectrophotometry met

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Bober-Majnusz, Katarzyna, and Alina Pyka-Pająk. "Comparison of the Limit of Detection of Paracetamol, Propyphenazone, and Caffeine Analyzed Using Thin-Layer Chromatography and High-Performance Thin-Layer Chromatography." Processes 12, no. 6 (2024): 1153. http://dx.doi.org/10.3390/pr12061153.

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TLC (thin-layer chromatography) and HPTLC (high-performance thin-layer chromatography) in normal (NP) and reversed (RP) phase systems were combined with densitometry to analyze caffeine, propyphenazone, and paracetamol. This work aims to check whether comparable limit of detection (LOD) values can be obtained on TLC and HPTLC plates. Analyses were performed on five (NP) or four (RP) different stationary phases (chromatographic plates), testing, in both cases, three mobile phases. It is shown that by using both TLC and HPTLC plates, it is possible to develop chromatographic conditions that enab

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Viji, Zereena, and Paulsamy S. "PRELIMINARY PHYTOCHEMICAL SCREENING AND HPTLC FINGER PRINTING ANALYSIS OF TRADITIONAL MEDICINAL PLANT PUERARIA TUBEROSA (ROXB. EX WILLD.)DC." Kongunadu Research Journal 5, no. 1 (2018): 56–59. http://dx.doi.org/10.26524/krj254.

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The medicinal value of a plant lies in the phytoconstituents present in it. These phytochemical compounds form the base of modern drugs. The aim of the present study is to identify the phytochemical constituents present in the traditional medicinal plant Pueraria tuberosa and to develop HPTLC fingerprint profile of acetone extract. Preliminary phytochemical screening was done to identify the phytoconstituents and HPTLC studies were carried out. CAMAG make HPTLC system equipped with Linomat 5applicator, TLC scanner 3, Reprostar 3 and WINCATS-1.4.3 software were used. The present study revealed

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Abbas, Samah S., Maha A. Hegazy, Hassan A. M. Hendawy, Soheir A. Weshahy, and May H. Abdelwahab. "Resolution and Quantitation of Triamcinolone Acetonide and Its Coformulated Drug in the Presence of Its Impurities and Degradation Products by HPTLC and HPLC." Journal of AOAC INTERNATIONAL 101, no. 4 (2018): 981–91. http://dx.doi.org/10.5740/jaoacint.16-0422.

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Abstract Two specific, sensitive, and precise stability-indicating chromatographic methods have been developed for the determination of triamcinolone acetonide (TMC) and its coformulated drug, econazole nitrate (ECZ), in the presence of TMC impurities and degradation products. The first method was based on HPTLC-spectrodensitometry in which resolution and quantitation was achieved by using silica gel 60 F254 HPTLC plates and an ethyl acetate–tetrahydrofuran–ammonia mobile phase (10.0 + 7.0 + 0.1, v/v/v). The second method was a reversed-phase HPLC method in which separation was achieved using

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Rab, Rehan Abdur, Sultan Zahiruddin, Mohammad Ibrahim, et al. "HPTLC and UPLC-MS/MS Methods for Quality Control Analysis of Itrifal Formulations of Unani System of Medicine." Journal of AOAC INTERNATIONAL 103, no. 3 (2020): 649–58. http://dx.doi.org/10.5740/jaoacint.19-0231.

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Abstract Background: Ultra-performance LC (UPLC)–tandem MS (MS/MS) and high-performance TLC (HPTLC) assay methods were developed for chemical fingerprinting and quantitative analysis of bioactive constituents of a certain “Itrifal formulation,” a traditional kind of Unani medicine. Objective: In the present investigation, HPTLC and UPLC-MS/MS methods were developed and validated for the detection and quantification of major metabolites present in itrifal formulation. Methods: The metabolites present in the formulation were separated using modern chromatographic techniques, and a quantitative a

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Yue, Yongde, Rong Zhang, Wei Fan, and Feng Tang. "High-Performance Thin-Layer Chromatographic Analysis of Selected Organophosphorous Pesticide Residues in Tea." Journal of AOAC INTERNATIONAL 91, no. 5 (2008): 1210–17. http://dx.doi.org/10.1093/jaoac/91.5.1210.

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Abstract The separation of 9 organophosphates (monocrotophos, quinalphos, triazophos, parathion-methyl, isofenphos-methyl, temephos, parathion, phoxim-ethyl, and chlorpyrifos) by high-performance thin-layer chromatography (HPTLC) with automated multiple development was studied. The HPTLC method was developed and validated for analysis of residues of phoxim-ethyl and chlorpyrifos in tea. The sample was extracted with acetonitrile and cleaned up by ENVI-CARB solid-phase extraction. The extract was directly applied as bands to glass-backed silica gel 60F254 HPTLC plates. The plates were developed

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P. Bhatkande, Apurva, and Prafullchandra Teklae. "HPTLC–densitometric and HPTLC–MS Methods for Analysis of Triterpenoids from Cucurbita maxima Peel." Journal of Plant Science Research 38, no. 2 (2023): 717–24. http://dx.doi.org/10.32381/jpsr.2022.38.02.25.

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Fruits and vegetables are integral part of our day to day. They are the main source of food for the living system. Large amount of agro-waste generated from food industries and kitchen pertaining to biggest nutritional loss, environmental problems and economical implications. Even though pomace, peels, rind and seeds are considered a waste part of plant they are still rich source of valuable compounds like polyphenols, oils, enzymes, vitamins, fiber, etc. which is just adjunct to its different uses. Present study conducted on waste pumpkin peel. HPTLC fingerprint profile of pumpkin peel methan

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Ragab, Marwa A. A., Mohamed H. Abdel-Hay, Hytham M. Ahmed, and Sara M. Mohyeldin. "Determination of Ibuprofen and Phenylephrine in Tablets by High-Performance Thin Layer Chromatography and in Plasma by High-Performance Liquid Chromatography with Diode Array Detection." Journal of Chromatographic Science 57, no. 7 (2019): 592–99. http://dx.doi.org/10.1093/chromsci/bmz031.

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Abstract Two chromatographic methods (high performance thin layer chromatography (HPTLC) and high performance liquid chromatography–diode array detector (HPLC-DAD)), were addressed for the analysis of a mixture consisted of phenylephrine hydrochloride and ibuprofen in two forms bulk and their combined dosage form. This binary mixture is considered to be a challenging one as the two drugs differ greatly in their chemical and physical properties. Not only this affects their simultaneous analysis, but also hinders their simultaneous extraction from biological fluids as plasma. That is the reason

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Morlock, Gertrud, and Elena Chernetsova. "Coupling of planar chromatography with Direct Analysis in Real Time mass spectrometry." Open Chemistry 10, no. 3 (2012): 703–10. http://dx.doi.org/10.2478/s11532-012-0025-2.

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AbstractDirect Analysis in Real Time mass spectrometry (DART-MS) is an emerging and rapidly developing area of ambient desorption ionization mass spectrometric techniques. Its coupling with planar chromatography is especially promising, as compared to other ambient desorption ionization techniques, because it does not require the use of liquids that may distort the shape of a spot by diffusion effects. In the first publications on TLC/HPTLC-DART-MS, due to the fixed, horizontally aligned supply of the gas flow from the DART ionization source to the MS inlet, the introduction of HPTLC/TLC plate

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Onjia, Antonije, Tatjana Vasiljevic, Djuro Cokesa, and Mila Lausevic. "Validation of chromatographic analysis." Chemical Industry 56, no. 2 (2002): 76–79. http://dx.doi.org/10.2298/hemind0202076o.

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The parameters for the development of a chromatographic (HPLC) method and its validation are discused in the paper. Chromatographic analysis involves a multi-step procedure consisting of sample collection, pretreatment instrumental measurements and data processing. Emphasize was placed on the instrumental part of the analysis presuming that the contributions of the other variables were minor. The roles of precision, accuracy, detection limit, quantification limit, specificity, selectivity, range, linearity and robustness, as well as system suitability in the analytical application of chromatog

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