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Journal articles on the topic 'HRSV'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Vieira, Sandra E., Luciano M. Thomazelli, Milena de Paulis, et al. "Infections Caused by HRSV A ON1 Are Predominant among Hospitalized Infants with Bronchiolitis in São Paulo City." BioMed Research International 2017 (2017): 1–7. http://dx.doi.org/10.1155/2017/3459785.

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Human respiratory syncytial virus is the main cause of respiratory infections in infants. Several HRSV genotypes have been described. Goals. To describe the main genotypes that caused infections in São Paulo (2013–2015) and to analyze their clinical/epidemiological features. Methods. 94 infants (0–6 months) with bronchiolitis were studied. Clinical/epidemiological information was collected; a search for 16 viruses in nasopharyngeal secretion (PCR-real-time and conventional, sequencing, and phylogenetic analyses) was performed. Results. The mean age was 2.4 m; 48% were male. The mean length of

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Bartalucci, Niccolò, Francesco Mannelli, Danilo Tarantino, et al. "Identification of Genomic Structural Variants (SVs) with Adverse Prognostic Significance in Normal-Karyotype (nk) Acute Myeloid Leukemia (AML) Patients." Blood 144, Supplement 1 (2024): 65. https://doi.org/10.1182/blood-2024-198342.

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Background: nkAML accounts for 40% of all AML. Although nkAML pts are included into favorable (fav) and intermediate (int) European Leukemia Net (ELN2022) risk category, the outcome is highly heterogeneous, and poses therapeutic challenges particularly as regards indication to stem cell transplant (SCT). Aim: To improve ELN-based prognostication, we characterized genomic SVs in nkAML pts through Long-Read Whole Genome Sequencing (WG-LRS). Methods: A total of 311 intensively treated nkAML pts were included; a discovery cohort (DC) was made up of 162 pts from the prospective NILG 02/06 and GIMEM

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3

Prokopyeva, Elena Alexandrovna, Olga Grigoryevna Kurskaya, Mariya Vladimirovna Solomatina, et al. "Virological and genetic characteristics of human respiratory syncytial viruses isolated in Russia, 2017-2018." Journal of Infection in Developing Countries 17, no. 02 (2023): 251–59. http://dx.doi.org/10.3855/jidc.17462.

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Isolation of human respiratory syncytial virus (HRSV) from clinical samples and storage of isolates for long period remains a considerable problem. We describe in detail the optimized conditions of HRSV isolation and cultivation in three cell cultures HeLa, HEp-2, and Vero. HRSV was detected in 35.2% (166/471) specimens by real-time PCR from symptomatic infants and children up to 15 years from October 2017 to March 2018 in Russia. HRSV-positive samples were used for virus isolation in HeLa, HEp-2, and Vero cells in different manners (in monolayer or suspension). To optimize the conditions of H

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4

Oomens, A. G. P., and Gail W. Wertz. "trans-Complementation Allows Recovery of Human Respiratory Syncytial Viruses That Are Infectious but Deficient in Cell-to-Cell Transmission." Journal of Virology 78, no. 17 (2004): 9064–72. http://dx.doi.org/10.1128/jvi.78.17.9064-9072.2004.

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ABSTRACT Human respiratory syncytial virus (HRSV) expresses three transmembrane glycoproteins: small hydrophobic protein SH, attachment protein G, and fusion protein F. The genes encoding SH and G can be deleted from the HRSV genome and infectious virus recovered. In contrast, HRSVs lacking the F gene or a functional replacement thereof have not been reported. To generate a system with which to study the roles of the viral transmembrane glycoproteins, including F, in the HRSV life cycle, we generated a cell line expressing a heterologous viral glycoprotein for complementation of glycoprotein f

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Oomens, A. G. P., and Gail W. Wertz. "The Baculovirus GP64 Protein Mediates Highly Stable Infectivity of a Human Respiratory Syncytial Virus Lacking Its Homologous Transmembrane Glycoproteins." Journal of Virology 78, no. 1 (2004): 124–35. http://dx.doi.org/10.1128/jvi.78.1.124-135.2004.

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ABSTRACT Baculovirus GP64 is a low-pH-dependent membrane fusion protein required for virus entry and cell-to-cell transmission. Recently, GP64 has generated interest for practical applications in mammalian systems. Here we examined the membrane fusion function of GP64 from Autographa californica multiple nucleopolyhedrovirus (AcMNPV) expressed in mammalian cells, as well as its capacity to functionally complement a mammalian virus, human respiratory syncytial virus (HRSV). Both authentic GP64 and GP64/F, a chimeric protein in which the GP64 cytoplasmic tail domain was replaced with the 12 C-te

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6

Santos-Rosa, H., and A. Aguilera. "Isolation and genetic analysis of extragenic suppressors of the hyper-deletion phenotype of the Saccharomyces cerevisiae hpr1 delta mutation." Genetics 139, no. 1 (1995): 57–66. http://dx.doi.org/10.1093/genetics/139.1.57.

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Abstract The HPR1 gene of Saccharomyces cerevisiae is involved in maintaining low levels of deletions between DNA repeats. To understand how deletions initiate in the absence of the Hpr1 protein and the mechanisms of recombination leading to deletions in S. cerevisiae, we have isolated mutations as suppressors of the hyper-deletion phenotype of the hpr1 delta mutation. The mutations defined five different genes called HRS for hyper-recombination suppression. They suppress the hyper-deletion phenotype of hpr1 delta strains for three direct repeat systems tested. The mutations eliminated the hyp

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Moumbeket Yifomnjou, Moïse Henri, Gwladys Chavely Monamele, Abdou Fatawou Modiyinji, Mohamadou Njankouo-Ripa, Boyomo Onana, and Richard Njouom. "Genetic Diversity of Human Respiratory Syncytial Virus during COVID-19 Pandemic in Yaoundé, Cameroon, 2020–2021." Microorganisms 12, no. 5 (2024): 952. http://dx.doi.org/10.3390/microorganisms12050952.

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Worldwide, human respiratory syncytial virus (HRSV) is a major cause of severe infections of the lower respiratory system, affecting individuals of all ages. This study investigated the genetic variability of HRSV during the COVID-19 outbreak in Yaoundé; nasopharyngeal samples positive for HRSV were collected from different age groups between July 2020 and October 2021. A semi-nested RT-PCR was performed on the second hypervariable region of the G gene of detected HRSV, followed by sequencing and phylogenetic assessment. Throughout the study, 40 (37.7%) of the 106 HRSV-positive samples success

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8

Tramuto, Fabio, Carmelo Massimo Maida, Daniela Di Naro, et al. "Respiratory Syncytial Virus: New Challenges for Molecular Epidemiology Surveillance and Vaccination Strategy in Patients with ILI/SARI." Vaccines 9, no. 11 (2021): 1334. http://dx.doi.org/10.3390/vaccines9111334.

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Several respiratory pathogens are responsible for influenza-like illness (ILI) and severe respiratory infections (SARI), among which human respiratory syncytial virus (hRSV) represents one of the most common aetiologies. We analysed the hRSV prevalence among subjects with ILI or SARI during the five influenza seasons before the emergence of SARS-CoV-2 epidemic in Sicily (Italy). Respiratory specimens from ILI outpatients and SARI inpatients were collected in the framework of the Italian Network for the Influenza Surveillance and molecularly tested for hRSV-A and hRSV-B. Overall, 8.1% of patien

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9

SHOBUGAWA, Y., T. TAKEUCHI, A. HIBINO, et al. "Occurrence of human respiratory syncytial virus in summer in Japan." Epidemiology and Infection 145, no. 2 (2016): 272–84. http://dx.doi.org/10.1017/s095026881600220x.

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SUMMARYIn temperate zones, human respiratory syncytial virus (HRSV) outbreaks typically occur in cold weather, i.e. in late autumn and winter. However, recent outbreaks in Japan have tended to start during summer and autumn. This study examined associations of meteorological conditions with the numbers of HRSV cases reported in summer in Japan. Using data from the HRSV national surveillance system and national meteorological data for summer during the period 2007–2014, we utilized negative binomial logistic regression analysis to identify associations between meteorological conditions and repo

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10

Martínez-Marrero, Nadia, Juan Carlos Muñoz-Escalante, Rosa Maria Wong-Chew, et al. "Genotypic Characterization of Human Respiratory Syncytial Viruses Detected in Mexico Between 2021 and 2024." Viruses 17, no. 5 (2025): 651. https://doi.org/10.3390/v17050651.

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Human respiratory syncytial virus (HRSV) is a leading cause of severe respiratory infections among children, older adults, and immunocompromised individuals. The COVID-19 pandemic and the non-pharmacological interventions to mitigate it resulted in significant changes in HRSV epidemiology and seasonality patterns. Worldwide, there was a considerable reduction in the number of HRSV infections during that period, and the impact of those changes on genotype distribution is still not fully understood. In this work, we analyzed the genotypic characteristics of HRSV strains detected between 2021 and

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de Souza Cardoso, Ricardo, Rosa Maria Mendes Viana, Brenda Cristina Vitti, et al. "Human Respiratory Syncytial Virus Infection in a Human T Cell Line Is Hampered at Multiple Steps." Viruses 13, no. 2 (2021): 231. http://dx.doi.org/10.3390/v13020231.

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Human respiratory syncytial virus (HRSV) is the most frequent cause of severe respiratory disease in children. The main targets of HRSV infection are epithelial cells of the respiratory tract, and the great majority of the studies regarding HRSV infection are done in respiratory cells. Recently, the interest on respiratory virus infection of lymphoid cells has been growing, but details of the interaction of HRSV with lymphoid cells remain unknown. Therefore, this study was done to assess the relationship of HRSV with A3.01 cells, a human CD4+ T cell line. Using flow cytometry and fluorescent f

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12

Spann, Kirsten M., Kim C. Tran та Peter L. Collins. "Effects of Nonstructural Proteins NS1 and NS2 of Human Respiratory Syncytial Virus on Interferon Regulatory Factor 3, NF-κB, and Proinflammatory Cytokines". Journal of Virology 79, № 9 (2005): 5353–62. http://dx.doi.org/10.1128/jvi.79.9.5353-5362.2005.

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ABSTRACT Human respiratory syncytial virus (HRSV) is the leading cause of serious pediatric acute respiratory tract infections, and a better understanding is needed of the host response to HRSV and its attenuated vaccine derivatives. It has been shown previously that HRSV nonstructural proteins 1 and 2 (NS1 and NS2) inhibit the induction of alpha/beta interferon (IFN-α/β) in A549 cells and human macrophages. Two principal transcription factors for the early IFN-β and -α1 response are interferon regulatory factor 3 (IRF-3) and nuclear factor κB (NF-κB). At early times postinfection, wild-type H

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13

Virant, Monika Jevšnik, Manca Luštrek, Rok Kogoj, Miroslav Petrovec, and Tina Uršič. "Changes in HRSV Epidemiology but Not Circulating Variants in Hospitalized Children due to the Emergence of SARS-CoV-2." Viruses 15, no. 6 (2023): 1218. http://dx.doi.org/10.3390/v15061218.

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This study assesses the circulation of human respiratory syncytial virus (HRSV) genotypes before, during, and toward the end of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic in children and determines the influence of the pandemic on HRSV circulation patterns and evolution. Phylogenetic analysis of the hypervariable glycoprotein G gene was performed on 221/261 (84.7%) HRSV-positive samples and shows two separated clusters, one belonging to HRSV-A (129/221) and another to HRSV-B (92/221). All Slovenian HRSV-A strains contained the 72-nucleotide-long duplicated region

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14

Hu, Yihong, Zhenzhou Wan, Yonglin Mu, et al. "A quite sensitive fluorescent loop-mediated isothermal amplification for rapid detection of respiratory syncytial virus." Journal of Infection in Developing Countries 13, no. 12 (2019): 1135–41. http://dx.doi.org/10.3855/jidc.11549.

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Introduction: Human respiratory syncytial virus (hRSV) is a common respiratory virus closely related to respiratory tract infection (RTI). Rapid and accurate detection of hRSV is urgently needed to reduce the high morbidity and mortality due to hRSV infection. Methodology: Here, we established a highly sensitive and specific reverse-transcription loop-mediated isothermal amplification (RT-LAMP) assay for the rapid detection of A and B group hRSV simultaneously. The specific primer sets for hRSV A and B groups were designed in the M and M2-2 gene, respectively. SYTO 9 was used as the fluo

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15

Tramuto, Fabio, Carmelo Massimo Maida, Walter Mazzucco, et al. "Molecular Epidemiology and Genetic Diversity of Human Respiratory Syncytial Virus in Sicily during Pre- and Post-COVID-19 Surveillance Seasons." Pathogens 12, no. 9 (2023): 1099. http://dx.doi.org/10.3390/pathogens12091099.

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Human respiratory syncytial virus (hRSV) is an important pathogen of acute respiratory tract infection of global significance. In this study, we investigated the molecular epidemiology and the genetic variability of hRSV over seven surveillance seasons between 2015 and 2023 in Sicily, Italy. hRSV subgroups co-circulated through every season, although hRSV-B mostly prevailed. After the considerable reduction in the circulation of hRSV due to the widespread implementation of non-pharmaceutical preventive measures during the COVID-19 pandemic, hRSV rapidly re-emerged at a high intensity in 2022–2

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16

Suad H. AL-Bashar, Amin Suliman Badawy, and Belal Abdul-Rahman Mohammed. "Real time-PCR, ELISA, as an identification methods for Detection respiratory syncytial virus in children." Tikrit Journal of Pure Science 22, no. 2 (2023): 33–42. http://dx.doi.org/10.25130/tjps.v22i2.626.

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The study have been done to detecting HRSV infections among hospitalized children under 10 years old in Salahaldin Governorate, in addition to compare different diagnostic methods for detection of this virus. Nasopharyngeal Swabs (NPS) and whole blood samples were taken from 400 hospitalized children between end of August 2013, to the end of May 2014, each sample was analyzed for HRSV by Real time –PCR, IgM and IgG specific to HRSV determining from blood specimens in serum using enzyme linked immune sorbent assay (ELISA) technique. Nasopharyngeal Swab was more sensitive than the wh

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17

Rey-Jurado, Emma, Karen Bohmwald, Hernán G. Correa, and Alexis M. Kalergis. "TCR Repertoire Characterization for T Cells Expanded in Response to hRSV Infection in Mice Immunized with a Recombinant BCG Vaccine." Viruses 12, no. 2 (2020): 233. http://dx.doi.org/10.3390/v12020233.

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T cells play an essential role in the immune response against the human respiratory syncytial virus (hRSV). It has been described that both CD4+ and CD8+ T cells can contribute to the clearance of the virus during an infection. However, for some individuals, such an immune response can lead to an exacerbated and detrimental inflammatory response with high recruitment of neutrophils to the lungs. The receptor of most T cells is a heterodimer consisting of α and β chains (αβTCR) that upon antigen engagement induces the activation of these cells. The αβTCR molecule displays a broad sequence diver

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Lara-Hernandez, Ignacio, Juan Carlos Muñoz-Escalante, Sofía Bernal-Silva, et al. "Ultrastructural and Functional Characterization of Mitochondrial Dynamics Induced by Human Respiratory Syncytial Virus Infection in HEp-2 Cells." Viruses 15, no. 7 (2023): 1518. http://dx.doi.org/10.3390/v15071518.

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Human respiratory syncytial virus (hRSV) is the leading cause of acute lower respiratory tract infections in children under five years of age and older adults worldwide. During hRSV infection, host cells undergo changes in endomembrane organelles, including mitochondria. This organelle is responsible for energy production in the cell and plays an important role in the antiviral response. The present study focuses on characterizing the ultrastructural and functional changes during hRSV infection using thin-section transmission electron microscopy and RT-qPCR. Here we report that hRSV infection

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19

Haid, Sibylle, Christina Grethe, Dorothea Bankwitz, Thomas Grunwald, and Thomas Pietschmann. "Identification of a Human Respiratory Syncytial Virus Cell Entry Inhibitor by Using a Novel Lentiviral Pseudotype System." Journal of Virology 90, no. 6 (2015): 3065–73. http://dx.doi.org/10.1128/jvi.03074-15.

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ABSTRACTLentiviral budding is governed by group-specific antigens (Gag proteins) and proceeds in the absence of cognate viral envelope proteins, which has been exploited to create pseudotypes incorporating envelope proteins from nonlentiviral families. Here, we report the generation of infectious lentiviral pseudoparticles incorporating human respiratory syncytial virus (hRSV) F protein alone (hRSV-Fpp) or carrying SH, G, and F proteins (hRSV-SH/G/Fpp). These particles recapitulate key infection steps of authentic hRSV particles, including utilization of glycosaminoglycans and low-pH-independe

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Tramuto, Fabio, Carmelo Massimo Maida, Giulia Randazzo, et al. "Whole-Genome Sequencing and Genetic Diversity of Human Respiratory Syncytial Virus in Patients with Influenza-Like Illness in Sicily (Italy) from 2017 to 2023." Viruses 16, no. 6 (2024): 851. http://dx.doi.org/10.3390/v16060851.

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Monitoring the genetic variability of human respiratory syncytial virus (hRSV) is of paramount importance, especially for the potential implication of key antigenic mutations on the emergence of immune escape variants. Thus, to describe the genetic diversity and evolutionary dynamics of hRSV circulating in Sicily (Italy), a total of 153 hRSV whole-genome sequences collected from 770 hRSV-positive subjects between 2017 and 2023, before the introduction of expanded immunization programs into the population, were investigated. The phylogenetic analyses indicated that the genotypes GA.2.3.5 (ON1)

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Ali, Suha Hanoon, Arwa Mujahid Abdullah Al-Shuwaikh, and Hala Sameh Arif. "An investigation of risk factors associated with respiratory syncytial virus infection in a sample of infants and young children from baghdad." Journal of Biotechnology Research Center 13, no. 1 (2019): 29–34. http://dx.doi.org/10.24126/jobrc.2019.13.1.565.

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Background: Human Respiratory Syncytial virus (hRSV) is one of the major causes of viral respiratory tract infection in infants and young children. Aim of study: The aim of this study was to determine the risk factors associated with hRSV infection. Objective: This study included 100 hospitalized infants and young children with chest infection (39 female and 61 male) aged from (1) to (24) months, their mean age (6.87) months. Material and methods: Nasopharyngeal/throat swabs specimens were collected over a three-month winter period from January to April, 2017. hRSV was determ

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22

Aljabr, Waleed, Stuart Armstrong, Natasha Y. Rickett, et al. "High Resolution Analysis of Respiratory Syncytial Virus Infection In Vivo." Viruses 11, no. 10 (2019): 926. http://dx.doi.org/10.3390/v11100926.

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Human respiratory syncytial virus (HRSV) is a major cause of pediatric infection and also causes disease in the elderly and those with underlying respiratory problems. There is no vaccine for HRSV and anti-viral therapeutics are not broadly applicable. To investigate the effect of HRSV biology in children, nasopharyngeal aspirates were taken from children with different viral loads and a combined high throughput RNAseq and label free quantitative proteomics approach was used to characterize the nucleic acid and proteins in these samples. HRSV proteins were identified in the nasopharyngeal aspi

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Kotelkin, Alexander, Igor M. Belyakov, Lijuan Yang, Jay A. Berzofsky, Peter L. Collins, and Alexander Bukreyev. "The NS2 Protein of Human Respiratory Syncytial Virus Suppresses the Cytotoxic T-Cell Response as a Consequence of Suppressing the Type I Interferon Response." Journal of Virology 80, no. 12 (2006): 5958–67. http://dx.doi.org/10.1128/jvi.00181-06.

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ABSTRACT The NS1 and NS2 proteins of human respiratory syncytial virus (HRSV) have been shown to antagonize the type I interferon (IFN) response, an effect subject to host range constraints. We have now found that the HRSV NS2 protein strongly controls IFN induction in mouse cells in vitro, validating the use of the mouse model to study the consequences of these gene deletions on host immunity. We evaluated the effects of deleting the NS1 and/or NS2 gene on the induction of HRSV-specific pulmonary cytotoxic T lymphocytes (CTL) in BALB/c and 129S6 mice in response to intranasal infection with H

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Curini, Valentina, Maurilia Marcacci, Salma Abid, et al. "Full Genome Characterization of Respiratory Syncytial Virus Causing a Fatal Infection in an Immunocompromised Patient in Tunisia." Pathogens 11, no. 7 (2022): 758. http://dx.doi.org/10.3390/pathogens11070758.

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Human orthopneumovirus (HRSV) is a virus belonging to the Pneumovirus genus that causes lower respiratory tract infections (LRTI) in infants worldwide. In Tunisia, thousands of infants hospitalized for LRTI are found to be positive for HRSV but no whole genome sequences of HRSV strains circulating in this country are available thus far. In this study, five nasal swab samples collected at different time points from a three-month-old female baby with severe immunodeficiency that was hospitalized for acute bronchiolitis were investigated by next generation sequencing. The Tunisian sequences from

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Oberst, Richard D., Michael P. Hays, Jim F. Evermann, and Clayton L. Kelling. "Characteristic Differences in Reverse Transcription-Polymerase Chain Reaction Products of Ovine, Bovine, and Human Respiratory Syncytial Viruses." Journal of Veterinary Diagnostic Investigation 5, no. 3 (1993): 322–28. http://dx.doi.org/10.1177/104063879300500303.

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In reverse transcription-polymerase chain reactions (RT-PCR) and DNA hybridizations using primers and an oligonucleotide probe to the fusion (F) protein mRNA of bovine respiratory syncytial virus (BRSV), all the BRSV isolates and a goat isolate could be distinguished from prototype isolates of human respiratory syncytial viruses (HRSV) and ovine (sheep and bighorn sheep) respiratory syncytial viruses (RSV). However, RT-PCR amplifications with primers to sequences of the HRSV F protein mRNA resulted in amplified products of ≍ 243 bp if mRNA templates of subgroup A HRSV strains were present and

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Al-Shuwaikh, Arwa, Suha Ali, and Hala Arif. "DETECTION OF RESPIRATORY SYNCYTIAL VIRUS IN INFANTS AND YOUNG CHILDREN WITH CHEST INFECTION: A COMPARISON OF REVERSE TRANSCRIPTION-PCR TECHNIQUE TO CHROMATOGRAPHIC IMMUNOASSAY AND ENZYME LINKED IMMUNOSORBENT ASSAY." Iraqi Journal of Medical Sciences 16, no. 3 (2018): 319–26. http://dx.doi.org/10.22578/ijms.16.3.11.

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Background: Human respiratory syncytial virus (hRSV) is a major cause of viral lower respiratory tract infection among infants and young children less than 2 years old. Multiple methods are used for the laboratory diagnosis of hRSV infections, including chromatographic immunoassay, enzyme linked immunosorbent assay (ELISA) and reverse transcription polymerase chain reaction (RT-PCR) technique for detection hRSV-antigens, hRSV-antibodies and hRSV-RNA, respectively. Objective: To compare the efficiency of three diagnostic methods in detection of hRSV in infants and young children with chest infe

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Buchholz, Ursula J., Harald Granzow, Kathrin Schuldt, Stephen S. Whitehead, Brian R. Murphy, and Peter L. Collins. "Chimeric Bovine Respiratory Syncytial Virus with Glycoprotein Gene Substitutions from Human Respiratory Syncytial Virus (HRSV): Effects on Host Range and Evaluation as a Live-Attenuated HRSV Vaccine." Journal of Virology 74, no. 3 (2000): 1187–99. http://dx.doi.org/10.1128/jvi.74.3.1187-1199.2000.

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ABSTRACT We recently developed a system for the generation of infectious bovine respiratory syncytial virus (BRSV) from cDNA. Here, we report the recovery of fully viable chimeric recombinant BRSVs (rBRSVs) that carry human respiratory syncytial virus (HRSV) glycoproteins in place of their BRSV counterparts, thus combining the replication machinery of BRSV with the major antigenic determinants of HRSV. A cDNA encoding the BRSV antigenome was modified so that the complete G and F genes, including the gene start and gene end signals, were replaced by their HRSV A2 counterparts. Alternatively, th

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Pearson, Hayley, Eleanor J. A. A. Todd, Mareike Ahrends, et al. "TMEM16A/ANO1 calcium-activated chloride channel as a novel target for the treatment of human respiratory syncytial virus infection." Thorax 76, no. 1 (2020): 64–72. http://dx.doi.org/10.1136/thoraxjnl-2020-215171.

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IntroductionHuman respiratory syncytial virus (HRSV) is a common cause of respiratory tract infections (RTIs) globally and is one of the most fatal infectious diseases for infants in developing countries. Of those infected, 25%–40% aged ≤1 year develop severe lower RTIs leading to pneumonia and bronchiolitis, with ~10% requiring hospitalisation. Evidence also suggests that HRSV infection early in life is a major cause of adult asthma. There is no HRSV vaccine, and the only clinically approved treatment is immunoprophylaxis that is expensive and only moderately effective. New anti-HRSV therapeu

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Kalkeri, Raj, Govinda Bhisetti, and Nagraj Mani. "Human respiratory syncytial virus methyl transferase: a potential antiviral target?" F1000Research 8 (May 29, 2019): 750. http://dx.doi.org/10.12688/f1000research.18800.1.

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Human respiratory syncytial virus (HRSV) causes bronchiolitis and pneumonia. The role of methyltransferase (MTase) activity of HRSV polymerase in viral replication is unknown. Literature reviews of similar viral MTases and homology- modeling of RSV MTase bound to GTP and S-adenosylmethionine (SAM) have shown sequence similarity and the conserved catalytic residues (K-D-K-E) and the SAM-binding (GXGXG) domain. Combined with the recent reports of the importance of 2’O methylation of viral RNAs in the host innate immune response evasion, and its proposed role in viral replication, HRSV MTase hold

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Kalkeri, Raj, Govinda Bhisetti, and Nagraj Mani. "Human respiratory syncytial virus methyl transferase: a potential antiviral target?" F1000Research 8 (September 23, 2019): 750. http://dx.doi.org/10.12688/f1000research.18800.2.

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Human respiratory syncytial virus (HRSV) causes bronchiolitis and pneumonia. The role of methyltransferase (MTase) activity of HRSV polymerase in viral replication is unknown. Literature reviews of similar viral MTases and homology- modeling of RSV MTase bound to GTP and S-adenosylmethionine (SAM) have shown sequence similarity and the conserved catalytic residues (K-D-K-E) and the SAM-binding (GXGXG) domain. Combined with the recent reports of the importance of 2’O methylation of viral RNAs in the host innate immune response evasion, and its proposed role in viral replication, HRSV MTase hold

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Boccalini, Sara, Benedetta Bonito, Cristina Salvati, et al. "Human Respiratory Syncytial Virus Epidemiological Burden in Pediatric Outpatients in Italy: A Systematic Review." Vaccines 11, no. 9 (2023): 1484. http://dx.doi.org/10.3390/vaccines11091484.

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Background: Human respiratory syncytial virus (hRSV) is a key contributor to lower respiratory tract infections (LRTIs), affecting children aged 0–5 years and often leading to outpatient visits, emergency department utilization, and hospitalization. With the development of hRSV vaccines for mitigation, understanding the epidemiological impact of hRSV infections among 0–5-year-old pediatric outpatients in Italy is crucial. Methods: This systematic review conducted searches on PubMed, Embase, Scopus, and the International HTA Database, yielding 20,845 English and Italian records from January 200

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Attaianese, Federica, Sara Guiducci, Sandra Trapani, et al. "Reshaping Our Knowledge: Advancements in Understanding the Immune Response to Human Respiratory Syncytial Virus." Pathogens 12, no. 9 (2023): 1118. http://dx.doi.org/10.3390/pathogens12091118.

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Human respiratory syncytial virus (hRSV) is a significant cause of respiratory tract infections, particularly in young children and older adults. In this review, we aimed to comprehensively summarize what is known about the immune response to hRSV infection. We described the innate and adaptive immune components involved, including the recognition of RSV, the inflammatory response, the role of natural killer (NK) cells, antigen presentation, T cell response, and antibody production. Understanding the complex immune response to hRSV infection is crucial for developing effective interventions ag

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Canedo-Marroquín, Gisela, Jorge A. Soto, Catalina A. Andrade, Susan M. Bueno, and Alexis M. Kalergis. "Increased Heme Oxygenase 1 Expression upon a Primary Exposure to the Respiratory Syncytial Virus and a Secondary Mycobacterium bovis Infection." Antioxidants 11, no. 8 (2022): 1453. http://dx.doi.org/10.3390/antiox11081453.

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The human respiratory syncytial virus (hRSV) is the leading cause of severe lower respiratory tract infections in infants. Because recurrent epidemics based on reinfection occur in children and adults, hRSV has gained interest as a potential primary pathogen favoring secondary opportunistic infections. Several infection models have shown different mechanisms by which hRSV promotes immunopathology to prevent the development of adaptive protective immunity. However, little is known about the long-lasting effects of viral infection on pulmonary immune surveillance mechanisms. As a first approach,

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Rijsbergen, Laurine C., Linda J. Rennick, Brigitta M. Laksono, et al. "In vivo comparison of a laboratory-adapted and clinical-isolate-based recombinant human respiratory syncytial virus." Journal of General Virology 101, no. 10 (2020): 1037–46. http://dx.doi.org/10.1099/jgv.0.001468.

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Human respiratory syncytial virus (HRSV) is the leading cause of severe respiratory tract disease in infants. Most HRSV infections remain restricted to the upper respiratory tract (URT), but in a small percentage of patients the infection spreads to the lower respiratory tract, resulting in bronchiolitis or pneumonia. We have a limited understanding of HRSV pathogenesis and what factors determine disease severity, partly due to the widespread use of tissue-culture-adapted viruses. Here, we studied early viral dissemination and tropism of HRSV in cotton rats, BALB/cJ mice and C57BL/6 mice. We u

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Alkubaisi, Noorah A., Ibrahim M. Aziz, Asma N. Alsaleh, Abdulkarim F. Alhetheel, and Fahad N. Almajhdi. "Molecular Profiling of Inflammatory Mediators in Human Respiratory Syncytial Virus and Human Bocavirus Infection." Genes 14, no. 5 (2023): 1101. http://dx.doi.org/10.3390/genes14051101.

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Infections due to human respiratory syncytial virus (HRSV) and human bocavirus (HBoV) can mediate the release of several pro-inflammatory cytokines such as IL-6, IL-8, and TNF-α, which are usually associated with disease severity in children. In this study, the change in the expression profile of cytokines and chemokines were determined during HRSV, HBoV, and HRSV coinfection with HBoV in 75 nasopharyngeal aspirates (NPAs) samples, positive real-time reverse transcriptase PCR Assay (rRT-PCR) for HRSV (n = 36), HBoV (n = 23) infection alone or HRSV coinfection with HBoV (n = 16). The samples we

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Aljabr, Waleed, Olivier Touzelet, Georgios Pollakis, et al. "Investigating the Influence of Ribavirin on Human Respiratory Syncytial Virus RNA Synthesis by Using a High-Resolution Transcriptome Sequencing Approach." Journal of Virology 90, no. 10 (2015): 4876–88. http://dx.doi.org/10.1128/jvi.02349-15.

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ABSTRACTHuman respiratory syncytial virus (HRSV) is a major cause of serious respiratory tract infection. Treatment options include administration of ribavirin, a purine analog, although the mechanism of its anti-HRSV activity is unknown. We used transcriptome sequencing (RNA-seq) to investigate the genome mutation frequency and viral mRNA accumulation in HRSV-infected cells that were left untreated or treated with ribavirin. In the absence of ribavirin, HRSV-specific transcripts accounted for up to one-third of total RNA reads from the infected-cell RNA population. Ribavirin treatment resulte

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Pacheco, Gaspar A., Nicolás M. S. Gálvez, Jorge A. Soto, Catalina A. Andrade, and Alexis M. Kalergis. "Bacterial and Viral Coinfections with the Human Respiratory Syncytial Virus." Microorganisms 9, no. 6 (2021): 1293. http://dx.doi.org/10.3390/microorganisms9061293.

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The human respiratory syncytial virus (hRSV) is one of the leading causes of acute lower respiratory tract infections in children under five years old. Notably, hRSV infections can give way to pneumonia and predispose to other respiratory complications later in life, such as asthma. Even though the social and economic burden associated with hRSV infections is tremendous, there are no approved vaccines to date to prevent the disease caused by this pathogen. Recently, coinfections and superinfections have turned into an active field of study, and interactions between many viral and bacterial pat

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Fausther-Bovendo, Hugues, Marie-Eve Hamelin, Julie Carbonneau, et al. "A Candidate Therapeutic Monoclonal Antibody Inhibits Both HRSV and HMPV Replication in Mice." Biomedicines 10, no. 10 (2022): 2516. http://dx.doi.org/10.3390/biomedicines10102516.

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Human metapneumovirus (HMPV) and human respiratory virus (HRSV) are two leading causes of acute respiratory tract infection in young children. While there is no licensed drug against HMPV, the monoclonal antibody (mAb) Palivizumab is approved against HRSV for prophylaxis use only. Novel therapeutics against both viruses are therefore needed. Here, we describe the identification of human mAbs targeting these viruses by using flow cytometry-based cell sorting. One hundred and two antibodies were initially identified from flow cytometry-based cell sorting as binding to the fusion protein from HRS

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Llorente, María T., Blanca García-Barreno, Miguel Calero та ін. "Structural analysis of the human respiratory syncytial virus phosphoprotein: characterization of an α-helical domain involved in oligomerization". Journal of General Virology 87, № 1 (2006): 159–69. http://dx.doi.org/10.1099/vir.0.81430-0.

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Human respiratory syncytial virus (HRSV) phosphoprotein (P), an essential cofactor of the viral polymerase, is much shorter (241 aa) than and has no sequence similarity to P of other paramyxoviruses. Nevertheless, bioinformatic analysis of HRSV P sequence revealed a modular organization, reminiscent of other paramyxovirus Ps, with a central structured domain (aa 100–200), flanked by two intrinsically disordered regions (1–99 and 201–241). To test the predicted structure experimentally, HRSV P was purified from cell extracts infected with recombinant vaccinia virus or HRSV. The estimated molecu

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Guo, Hong, Yang Song, Hai Li, et al. "A Mixture of T-Cell Epitope Peptides Derived from Human Respiratory Syncytial Virus F Protein Conferred Protection in DR1-TCR Tg Mice." Vaccines 12, no. 1 (2024): 77. http://dx.doi.org/10.3390/vaccines12010077.

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Human respiratory syncytial virus (HRSV) poses a significant disease burden on global health. To date, two vaccines that primarily induce humoral immunity to prevent HRSV infection have been approved, whereas vaccines that primarily induce T-cell immunity have not yet been well-represented. To address this gap, 25 predicted T-cell epitope peptides derived from the HRSV fusion protein with high human leukocyte antigen (HLA) binding potential were synthesized, and their ability to be recognized by PBMC from previously infected HRSV cases was assessed using an ELISpot assay. Finally, nine T-cell

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Zadeh, S. Amiri, Haniyeh Abuei, Ali Farhadi, et al. "Sustained Suppression of Fusion Gene-mediated Human Respiratory Syncytial Virus Load by shRNA-based Therapeutics." Biomedical and Biotechnology Research Journal 7, no. 3 (2023): 464–70. https://doi.org/10.4103/bbrj.bbrj_163_23.

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Background: Human respiratory syncytial virus (HRSV) is a common cause of severe lower respiratory tract infections in infants and young children. There is no vaccine or effective treatment for this viral infection. However, Short hairpin RNA (shRNA) has many therapeutic applications, such as an effective treatment for viral infections. To find novel strategies to combat HRSV replication, specific shRNA targeting the HRSV fusion (F) gene was generated in the present study. The results were compared to ribavirin, the only Food and Drug Administration-approved antiviral drug to treat HRSV infect

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Yatsyshina, S. B. "PNEUMOVIRUSES IN HUMAN INFECTIOUS DISEASES." Journal of microbiology epidemiology immunobiology, no. 6 (December 28, 2017): 95–105. http://dx.doi.org/10.36233/0372-9311-2017-6-95-105.

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This review presents the actual data about structure, genetic diversity and pathogenicity factors of human respiratory syncytial virus (hRSv) and human metapneumovirus - which are the members of new Pneumoviridae family, according to updated taxonomy accepted by the International Committee on Taxonomy of Viruses (ICTV) in 2016. The results of own epidemiological and clinical studies are presented in comparison with literature data. Cyclic recurrence of hRSv circulation was revealed. The clinical and epidemiological characteristics of hRSv and hMpv infections were compared. The leading role of

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Andrade, Catalina A., Alexis M. Kalergis, and Karen Bohmwald. "Potential Neurocognitive Symptoms Due to Respiratory Syncytial Virus Infection." Pathogens 11, no. 1 (2021): 47. http://dx.doi.org/10.3390/pathogens11010047.

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Respiratory infections are among the major public health burdens, especially during winter. Along these lines, the human respiratory syncytial virus (hRSV) is the principal viral agent causing acute lower respiratory tract infections leading to hospitalization. The pulmonary manifestations due to hRSV infection are bronchiolitis and pneumonia, where the population most affected are infants and the elderly. However, recent evidence suggests that hRSV infection can impact the mother and fetus during pregnancy. Studies have indicated that hRSV can infect different cell types from the placenta and

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Céspedes, Pablo, Susan Bueno, Bruno Ramírez, et al. "The human respiratory syncytial virus nucleoprotein is expressed on the surface of dendritic cells and inhibits immunological synapse assembly by T cells (VIR2P.1018)." Journal of Immunology 192, no. 1_Supplement (2014): 75.7. http://dx.doi.org/10.4049/jimmunol.192.supp.75.7.

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Abstract The human Respiratory Syncytial Virus (hRSV) is the major cause of children severe respiratory tract infections worldwide. Both, the poor activation of T cells and the limited generation of memory T cells following disease resolution are considered key processes favoring hRSV epidemics, which are based on re-infections. It is known that hRSV infects Dendritic cells (DCs) dampening their capacity to prime antigen-specific naïve T cells, a process needed to mount a proper antiviral immune response and eliminate hRSV from the airways. Here we show that the hRSV Nucleoprotein (N) is expre

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Pankovics, Péter, Hajnalka Szabó, Gyöngyi Székely, Kálmán Gyurkovits, and Gábor Reuter. "Detection and molecular epidemiology of respiratory syncytial virus type A and B strains in childhood respiratory infections in Hungary." Orvosi Hetilap 150, no. 3 (2009): 121–27. http://dx.doi.org/10.1556/oh.2009.28473.

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Az emberi légúti óriássejtes vírus (hRSV) a csecsemő- és kisgyermekkori légúti fertőzések, járványok egyik leggyakoribb kórokozója világszerte. A hRSV molekuláris epidemiológiája nem ismert hazánkban, ma azonban már lehetőség van a vírus genetikai szintű kimutatására és nyomon követésére e módszerrel. Célkitűzés: A szerzők célja a hRSV molekuláris kimutatása és a vírusok genetikai elemzése volt gyermekkori légúti fertőzésekből hazánkban. Módszer: A garatmosó folyadékok a mosdósi kórházban kezelt 10 év alatti, légúti fertőzésben szenvedő gyermekektől származtak két légúti szezonból (2005/2006 é

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Beri, Nina, Jingjing Pei, Gaya Amarasinghe, Daisy Leung, and Jacqueline Payton. "hRSV nonstructural protein 1 (NS1) binds chromatin at regulatory regions of immune response genes." Journal of Immunology 206, no. 1_Supplement (2021): 112.10. http://dx.doi.org/10.4049/jimmunol.206.supp.112.10.

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Abstract Human respiratory syncytial virus (hRSV) causes severe acute respiratory tract infections in infants, elderly and immunocompromised people worldwide and few effective treatments are available. The hRSV nonstructural protein NS1 is known to inhibit host interferon responses in the cytoplasm. We and others have used in vitro interactome studies to identify host proteins that interact with NS1. Among these is the Mediator complex, a transcriptional coactivator localized in the nucleus, suggesting that NS1 may have a more direct role in modulating IFN-stimulated gene expression. We perfor

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Wang, Kuo Chih, Jung San Chang, Lien Chai Chiang, and Chun Ching Lin. "Cimicifuga foetida L. Inhibited Human Respiratory Syncytial Virus in HEp-2 and A549 Cell Lines." American Journal of Chinese Medicine 40, no. 01 (2012): 151–62. http://dx.doi.org/10.1142/s0192415x12500127.

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Human respiratory syncytial virus (HRSV) causes serious pediatric infection of the lower respiratory tract without effective therapeutic modality. Sheng-Ma-Ge-Gen-Tang (SMGGT; Shoma-kakkon-to) has been proven to be effective at inhibiting HRSV-induced plaque formation, and Cimicifuga foetida is the major constituent of SMGGT. We tested the hypothesis that C. foetida effectively inhibited the cytopathic effects of HRSV by a plaque reduction assay in both human upper (HEp2) and lower (A549) respiratory tract cell lines. Its ability to stimulate anti-viral cytokines was evaluated by an enzyme-lin

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Cheemarla, Nagarjuna R., Ifeanyi K. Uche, Kaitlin McBride, Shan Naidu, and Antonieta Guerrero-Plata. "In utero tobacco smoke exposure alters lung inflammation, viral clearance, and CD8+T-cell responses in neonatal mice infected with respiratory syncytial virus." American Journal of Physiology-Lung Cellular and Molecular Physiology 317, no. 2 (2019): L212—L221. http://dx.doi.org/10.1152/ajplung.00338.2018.

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Maternal smoking during pregnancy and exposure of infants to cigarette smoke are strongly associated with adverse health effects in childhood including higher susceptibility to respiratory viral infections. Human respiratory syncytial virus (HRSV) is the most important cause of lower respiratory tract infection among young infants. Exacerbation of respiratory disease, including HRSV bronchiolitis and higher susceptibility to HRSV infection, is well correlated with previous smoke exposure. The mechanisms of recurrence and susceptibility to viral pathogens after passive smoke exposure are multif

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Wagatsuma, Keita, Iain S. Koolhof, and Reiko Saito. "1199. Decreased Human Respiratory Syncytial Virus Activity during the COVID-19 Pandemic in Japan: An Ecological Time-Series Analysis, 2014 through 2020." Open Forum Infectious Diseases 8, Supplement_1 (2021): S690—S691. http://dx.doi.org/10.1093/ofid/ofab466.1391.

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Abstract Background Non-pharmaceutical interventions (NPIs), such as sanitary measures and travel restrictions, aimed at controlling the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), may affect the transmission dynamics of human respiratory syncytial virus (HRSV). We aimed to quantify the contribution of the sales of hand hygiene products and the number of international and domestic airline passenger arrivals on HRSV epidemic in Japan. Methods The monthly number of HRSV cases per sentinel site (HRSV activity) in 2020 was compared with the average of the corresponding period in

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de la Sota, Patricia G., Elena Lorente, Laura Notario, Carmen Mir, Oscar Zaragoza, and Daniel López. "Mitoxantrone Shows In Vitro, but Not In Vivo Antiviral Activity against Human Respiratory Syncytial Virus." Biomedicines 9, no. 9 (2021): 1176. http://dx.doi.org/10.3390/biomedicines9091176.

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Human respiratory syncytial virus (HRSV) is the most common cause of severe respiratory infections in infants and young children, often leading to hospitalization. In addition, this virus poses a serious health risk in immunocompromised individuals and the elderly. HRSV is also a major nosocomial hazard in healthcare service units for patients of all ages. Therefore, the development of antiviral treatments against HRSV is a global health priority. In this study, mitoxantrone, a synthetic anthraquinone with previously reported in vitro antiprotozoal and antiviral activities, inhibits HRSV repli

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