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Dissertations / Theses on the topic 'HSDH'

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Published: 9 March 2023
Last updated: 31 July 2025

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1

Argueso, Cristiana Morgado dos Guimarães Teixeira. "Identificação e purificação parcial de isoenzimas da aspartato quinase (AK) e homoserina desidrogenase (HSDH) de sementes de arroz (Oriza sativa) : evidencias para a existencia de um polipeptideo bifuncional com atividades de AK e HSDH." [s.n.], 1997. http://repositorio.unicamp.br/jspui/handle/REPOSIP/317254.

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Orientador: RIcardo Antunes de Azevedo<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-07-23T00:01:31Z (GMT). No. of bitstreams: 1 Argueso_CristianaMorgadodosGuimaraesTeixeira_M.pdf: 7441540 bytes, checksum: 47e2d4385d38c27ba690c5c89a9ab5e0 (MD5) Previous issue date: 1997<br>Mestrado<br>Genetica de Plantas<br>Mestre em Ciências Biológicas
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2

BERTULETTI, SUSANNA. "EXPLOITING OXIDOREDUCTASES, HYDROLASES AND TRANSAMINASES AS STEREO- AND REGIO-SELECTIVE BIOCATALYSTS IN ORGANIC SYNTHESIS." Doctoral thesis, Università degli Studi di Milano, 2022. http://hdl.handle.net/2434/886073.

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The thesis concerns the use of different enzyme classes (namely, oxidoreductases, transferases, and hydrolases) as biocatalysts to achieve the chemo-, regio- and stereo-selective green synthesis of pharmaceutically relevant compounds. The main work has been done with hydroxysteroid dehydrogenases, redox enzymes that naturally work on steroids, which were studied with two main purposes: to shorten the synthesis of valuable bile acids already sold as drugs or with potential biomarker application, and to synthesize active pharmaceutical ingredients of non-steroidal nature. The work has been compl
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3

Baum, Oliver. "HSOH an elusive species with many different traits." Göttingen Cuvillier, 2008. http://d-nb.info/991202996/04.

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4

Pereira, Laura E. "11ß-hydroxysteroid dehydrogenase 2 (11ß-HSD2), molecular structure and regulation." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape16/PQDD_0006/MQ32501.pdf.

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5

White, Christopher Iain. "Cardiovascular 11β-HSD1 : its role in myocardial physiology and pathophysiology". Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/23391.

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Glucocorticoid production by the adrenal gland is regulated by hypothalamicpituitary- adrenal (HPA) axis activity. Within cells, glucocorticoid levels are modulated by 11β-hydroxysteroid dehydrogenase (11β-HSD), which interconverts active and intrinsically inert glucocorticoids. Glucocorticoids have widespread physiological effects and, in the cardiovascular system, they play a crucial role in heart development and maturation, blood pressure control, and myocardial calcium cycling. Mice which are unable to regenerate the physiological glucocorticoid, corticosterone, from 11-dehydrocorticostero
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6

Leiva, Martínez Rosana. "Polycyclic group optimization in 11β-HSD1 inhibitors and their pharmacological evaluation". Doctoral thesis, Universitat de Barcelona, 2017. http://hdl.handle.net/10803/457770.

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The present PhD Thesis evolves around the design, synthesis and pharmacological evaluation of novel 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors. Given that the enzyme active site includes a hydrophobic pocket to accommodate bulky lipophilic scaffolds, the main objective was focused on the study of new 11β-HSD1 inhibitors exploring different hydrophobic polycyclic substituents. 11β-HSD1 catalyzes the cortisol regeneration from its inactive form cortisone in tissues mainly expressing glucocorticoid (GC) receptors, such as liver, adipose and brain. GCs are well known hormones t
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Craigie, Eilidh. "Investigating mechanisms of salt-sensitive hypertension in 11β-HSD2 heterozygote mice". Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/5565.

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The mineralocorticoid hormone, aldosterone, classically acts via the Mineralocorticoid Receptor (MR) to promote sodium transport in aldosterone target tissues, such as the kidney, thereby controlling long-term electrolyte homeostasis and blood pressure (BP). Aldosterone biosynthesis by the adrenal gland is regulated by a negative feedback loop called the Renin Angiotensin Aldosterone System (RAAS). The glucocorticoid cortisol (corticosterone in rodents), which has a very similar structure to aldosterone, shares with aldosterone an equal affinity for the MR. Typically, plasma cortisol levels ar
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8

Andres, Janin. "Untersuchungen über Regulationsmechanismen der 11beta-Hydroxysteroid Dehydrogenase Typ 1." Phd thesis, Universität Potsdam, 2008. http://opus.kobv.de/ubp/volltexte/2009/3303/.

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Die 11beta-HSD1 reguliert intrazellulär die Cortisolkonzentration durch Regeneration von Cortison z.B. aus dem Blutkreislauf, zu Cortisol. Daher stellt diese ein wichtiges Element in der Glucocorticoid-vermittelten Genregulation dar. Die 11beta-HSD1 wird ubiquitär exprimiert, auf hohem Niveau besonders in Leber, Fettgewebe und glatten Muskelzellen. Insbesondere die Bedeutung der 11beta-HSD1 in Leber und Fettgewebe konnte mehrfach nachgewiesen werden. In der Leber führte eine erhöhte Aktivität aufgrund einer Überexpression in Mäusen zu einer verstärkten Gluconeogeneserate. Des Weiteren konnte g
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9

Coutinho, Agnes Elizabeth. "Consequences of 11β-hydroxysteroid dehydrogenase deficiency during inflammatory responses". Thesis, University of Edinburgh, 2009. http://hdl.handle.net/1842/4190.

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Glucocorticoids profoundly influence the immune system and pharmacological doses exert potent anti-inflammatory actions. During inflammation, glucocorticoids limit oedema and influence cell trafficking, differentiation programmes and gene transcription in glucocorticoid-sensitive leukocytes. Within cells, glucocorticoid action is modulated by a pre-receptor mechanism; glucocorticoid metabolism by the enzyme 11β- hydroxysteroid dehydrogenase (11β-HSD). Two 11β-HSD isozymes exist: 11β-HSD1, which catalyses amplification of glucocorticoid levels in intact cells by oxo-reduction of intrinsically i
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10

Zhang, Zhenguang. "Role of macrophage 11β-HSD1 in inflammation mediated angiogenesis, arthritis and obesity". Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/9553.

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11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1, encoded by Hsd11b1) is an enzyme that predominantly converts inactive glucocorticoids (cortisone in human and most mammals, 11dehydro-corticosterone in mice and rats) into their active forms (cortisol and corticosterone, respectively). Thus 11β-HSD1 amplifies intracellular levels of glucocorticoids. Studies in globally 11β-HSD1 deficient mice have revealed changes in glucocorticoid-regulated physiological and pathological processes, including metabolism, aging, arthritis and angiogenesis. The function of macrophages, which play an important ro
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11

Weber, Agnes Johanna [Verfasser]. "Fracture healing and glucocorticoids in HSD2 transgenic mouse model / Agnes Johanna Weber." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2012. http://d-nb.info/1026694914/34.

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12

Wamil, Małgorzata. "Protective role of 11β-HSD1 inhibition in the metabolic syndrome and atherosclerosis". Thesis, University of Edinburgh, 2009. http://hdl.handle.net/1842/3891.

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Obesity is associated with an increased risk of diabetes type 2, dyslipidaemia and atherosclerosis. These cardiovascular and metabolic abnormalities are exacerbated by dietary fats such as cholesterol and its metabolites. High adipose tissue glucocorticoid levels, generated by the intracellular enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) are also implicated in the pathogenesis of obesity, metabolic syndrome and atherosclerosis. Transgenic mice over-expressing 11β-HSD1 selectively in adipose tissue develop the metabolic syndrome whereas 11β-HSD1-/- mice have a ‘cardioprotective’ p
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13

Mitić, Tijana. "Role of murine 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) in the metabolism of 7-oxysterols". Thesis, University of Edinburgh, 2010. http://hdl.handle.net/1842/4416.

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7-Oxysterols constitute the major component (40%) of oxidized low-density lipoprotein (oxLDL). They arise in the body via auto-oxidation of cholesterol and are known to induce endothelial dysfunction, oxidative stress and apoptosis in the vascular wall, prior to development of atherosclerosis. A novel pathway has been described for hepatic inter-conversion of 7-ketocholesterol (7-KC) and 7β -hydroxycholesterol (7β OHC) by the enzyme 11β-hydroxysteroid dehydrogenase type-1 (11β HSD1), better known for metabolizing glucocorticoids. Inhibition of 11βHSD1 is atheroprotective and the potential unde
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14

Lye, Mei Xuan. "The role of 11β-HSD1 in reference and working memory in ageing : investigating underlying mechanisms and biomarkers of age-associated cognitive decline". Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/22057.

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Glucocorticoids (GC) have a negative effect on age-associated cognitive decline and the GC metabolising enzyme 11β-hydroxysteroid dehydrogenase Type 1 (11β- HSD1) plays a key role in these effects. Increased glucocorticoids exert detrimental effects on the volume and function of brain regions such as the prefrontal cortex (PFC) and hippocampus that are necessary for cognitive functions such as memory and working memory. Previous research has identified changes in cell populations, metabolite levels and structure within the brain as well as altered levels of inflammation with age, and studies h
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15

Verma, Manu. "Deficiency of 11β-HSD1 modulates energy homeostasis in the brain following systemic inflammation". Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/33323.

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Chronically elevated brain glucocorticoid (GC) levels impair cognition. Age-related cognitive deficits or "sickness" behaviour is often associated with neuroinflammation. In rodents, raised GC levels prior to lipopolysaccharide (LPS) administration potentiate neuroinflammation although GC suppresses neuroinflammation if administered after LPS. 11β-hydroxysteroid dehydrogenase-1 (11β-HSD1) reductase activity can increase intracellular GC levels, including in the brain, without alteration in circulating levels. Deficiency/pharmacological inhibition of 11β-HSD1 is protective against age related c
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16

Liu, Bin. "Numerical investigation and evaluation of applying PPCI combustion in a HSDI diesel engine." Thesis, University of Sussex, 2014. http://sro.sussex.ac.uk/id/eprint/49394/.

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In this study, the Partially Premixed Compression Ignition (PPCI) combustion strategy in the high-speed, direct-injection diesel engine was investigated numerically by KIVA-3V code coupled with detailed chemistry, aiming to find the solution to meet the increasingly stringent emission regulations. Using split-injection, the parameters including injection timing, split-proportion, spray angle and injection pressures have been studied for their effects on combustion performance and emissions. The effects of swirl ratio, EGR rate and boost pressure are evaluated for improving the mixing and combu
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17

Liu, Xiaoxia. "Regulation and function of 11β-hydroxysteroid dehydrogenase (11β-HSD1) in pancreatic β-cells". Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/5582.

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Diabetes Mellitus is characterized by high blood sugar and is caused by resistance to (type 2) or insufficiency of (type 1) the pancreatic β-cell hormone insulin. Most commonly, type 2 diabetes is associated with obesity whereas type 1 diabetes is largely a result of immune-mediated destruction of the β-cell. One rare but significant cause of type 2 diabetes is excess blood glucocorticoid levels (Cushing’s syndrome). High circulating glucocorticoids potently induce metabolic disorders including peripheral insulin resistance in key metabolic tissues (muscle, liver and fat) as well as directly s
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18

Hein, Anna Caroline. "11ß-HSD2 dependent and independent signalling pathways in trophoblast biology and glucocorticoid responsiveness." Thesis, University of Warwick, 2015. http://wrap.warwick.ac.uk/77309/.

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The placenta is the interface between the mother and the fetus fulilling important roles such as nutrient transfer, hormone production and barrier functions. Pathological conditions associated with maternal stress during pregnancy can cause placental adaptations which possibly affect fetal health and might lead to long-term effects in later life. The placenta contains an autonomous endocrine system which consists of hormones such as corticotropin-releasing hormone (CRH) and cortisol (the human glucocorticoid) controlling stress responses. Exposure of the fetus and placenta to glucocorticoids (
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19

Ota, Takumi. "Regulatory Mechanisms of Adrenal Gland Zona Glomerulosa-Specific 3β-HSD". 京都大学 (Kyoto University), 2015. http://hdl.handle.net/2433/199496.

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20

Pu, Helen Xiaochun. "Cloning and characterization of 11ß-hydroxysteroid dehydrogenase 1 (11ß-HSD1) in the guinea pig." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ30819.pdf.

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21

Smith, Melanie Anne. "Biochemical and biophysical characterisation of the domain structure of the HsdS subunit of EcoR124I." Thesis, University of Portsmouth, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.323083.

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22

McCabe, Emma Louise. "Altering adipose tissue responses to glucocorticoids through genetic manipulation of the 11B-HSD1 gene." Thesis, University of Birmingham, 2016. http://etheses.bham.ac.uk//id/eprint/6917/.

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Glucocorticoids (GC) are regulators of permissive and adaptive physiology. GC excess can lead to metabolic complications including type 2 diabetes and metabolic syndrome. Levels are regulated by 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), which reactivates GC. 11β-HSD1 activity is deregulated in a range metabolic disorders in which GC levels are normal. I hypothesise that 11β-HSD1 is a critical regulator of adipose tissue sensitivity to GC excess, and that through 11β-HSD1 depletion adipose tissue will be desensitised to GCs and resist metabolic deregulation. Using 11β-HSD1 KO mice in
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23

Manwani, Kajal. "The role of hepatic 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) in cholesterol homeostasis". Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/22058.

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Chronic glucocorticoid (GC) excess (Cushing’s syndrome, pharmacotherapy) causes metabolic and cardiovascular disease. This might be predicted from the known metabolic (dyslipidaemia, insulin resistance/hyperglycaemia) and hypertensive effects of chronically elevated GC levels. Intracellular GC levels within target tissues are controlled by 11β-hydroxysteroid dehydrogenases. 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1, encoded by Hsd11b1) is an enzyme that, in intact cells and in vivo, converts inert GCs (cortisone in humans, and 11- dehydrocorticosterone in mice and rats) into their acti
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Tran, Van Nam. "Adsorption statique de PCB et de DDT sur charbons actifs en milieux aqueux." Thesis, Lyon 1, 2012. http://www.theses.fr/2012LYO10301.

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L’adsorption solide-liquide des PCB et des DDT constitue un moyen efficace pour leur récupération des eaux polluées à condition d’avoir une meilleure connaissance du mécanisme impliqué. Les cinétiques d’adsorption statique ont été principalement réalisées à 25 °C avec le2-PCB, un mélange de tétra-, penta- et hexa-CB et le 4,4’-DDT sur 3 charbons actifs (CA) en poudre différents par le précurseur (houille, bois) et le mode d’activation (H2O, H3PO4) dans l’eau, en présence ou non d’éthanol. Les résultats marquants ont été les suivants : L’adsorption du polluant sur le CA est d’autant plus favori
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Opiyo, Monica Naomi. "The role of glucocorticoid metabolism in bile acid homeostasis." Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/25673.

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Alterations in glucocorticoid (GC) biosynthesis and metabolism are associated with a variety of pathophysiological disorders including cholestasis, diabetes and other metabolic disorders. Bile acids (BA) are also important modulators of metabolic functions and regulate cholesterol, triglyceride and glucose homeostasis as well as being critical for dietary fat digestion, enterohepatic function, and postprandial thermogenesis. In intact cells and in vivo, the 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme converts inactive GC precursors (cortisone in humans, and 11-dehydrocorticostero
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DAMIANI, FRANCESCO. "11ß-HSD1: novel roles and implications in pathology and physiology of reproduction and in skin homeostasis." Doctoral thesis, Università di Siena, 2017. http://hdl.handle.net/11365/1005619.

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My three-years work focused on the enzyme 11B-HSD1 and its implications and roles in human reproduction and skin homeostasis. The enzyme is involved in the local regulation of glucocorticoids availability, being responsible of the cortisone activation to cortisol. My project was composed of three major parts. In the first section, I analyzed the role of the enzyme in the human first trimester decidua. My experiments included a global evaluation of the enzyme susceptibility to respond to hormonal and cytokine stimuli, driving the first part of pregnancy. Our findings reported that 11B-HSD1 e
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Pradhan, Devaleena S. "Rapid social regulation of 3β-HSD activity in the songbird brain". Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/1500.

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Rapid increases in plasma androgens are generally associated with short-term aggressive challenges in many breeding vertebrates. However, some animals such as song sparrows (Melospiza melodia) are aggressive year-round, even during the non-breeding season, when gonads are regressed and systemic testosterone (T) levels are non-detectable. In contrast, levels of the prohormone dehydroepiandrosterone (DHEA) are elevated year-round in the plasma and brain. The local conversion of brain DHEA to potent androgens may be critical in regulating non-breeding aggression. 3β-hydroxysteroid dehydrogena
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28

Glisson, Katelynn E. "The Ability of the U.S. Army Heat Strain Decision Aid (HSDA) to Predict a Limiting Heat Stress Exposure." Scholar Commons, 2017. http://scholarcommons.usf.edu/etd/7027.

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Working below the threshold limit value (TLV) for heat stress is not always feasible. When work above the TLV is required, an exposure method is needed that can help protect workers from time limiting heat stress by calculating a safe time for work at certain heat exposures. The purpose of this paper is to determine whether the USARIEM Heat Strain Decision Aid (HSDA) can be used to predict time limiting heat stress exposure in an occupational setting. Twelve adults participated in time limited heat stress exposures. A range of heat stress conditions were designed using thr
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Yin, Jennifer, and Chris Dehmelt. "A Common Solution to Custom Network Applications." International Foundation for Telemetering, 2007. http://hdl.handle.net/10150/604467.

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ITC/USA 2007 Conference Proceedings / The Forty-Third Annual International Telemetering Conference and Technical Exhibition / October 22-25, 2007 / Riviera Hotel & Convention Center, Las Vegas, Nevada<br>The deployment of networks has become ubiquitous in the avionics world, as they have opened the door to a rich suite of common and open hardware and software tools that provide greater functionality and interoperability. Unfortunately, a number of networked avionic and other related applications can be affected by vendor or application specific proprietary implementations. These “closed” i
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30

Iqbal, Javaid. "Role of intra-cellular glucocorticoid regulation in vascular lesion development." Thesis, University of Edinburgh, 2010. http://hdl.handle.net/1842/4810.

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Atherosclerosis and post-angioplasty neointimal proliferation, which are leading causes of cardiovascular morbidity and mortality, develop as a result of chronic or acute vascular injury producing inflammatory and proliferative responses in the vessel wall. Glucocorticoids, the stress hormones produced by the adrenal cortex, have anti-inflammatory and anti-proliferative characteristics and can also influence systemic cardiovascular risk factors. The systemic levels of these hormones are controlled by the hypothalamic pituitary adrenal axis. However, there is also a tissue-specific pre-receptor
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Hibberd, Carina Jayne. "Investigating the significance of 11β-HSD type 1 in the ageing brain". Thesis, University of Edinburgh, 2005. http://hdl.handle.net/1842/24698.

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In-situ-hybridisation of the mouse hippocampus and cerebellum, showed no changes in 11β-HSD1 mRNA with ageing. However, decreases in mRNA of corticosteroid receptors indicated a possible, neuro-protective mechanisms through changes in GC signalling. The improved ageing in a hippocampal –dependent behavioural task, was further investigated on a C57BL/6 background. Middle-aged mice showed improved long-term memory in a Y-maze spatial learning test, with no differences in short-term or working memory. In light of the GC role in anxiety and exploration, the elevated-plus-maze and open-field were i
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Darnel, Andrew D. "Regulation of endometrial 11ß-hydroxysteroid dehydrogenase (11ß-HSD) types I and II." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ39814.pdf.

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33

Patel, Jaynish. "The cloning, expression and mutagenesis of the recognition subunit, HsdS, from the EcoR124 R-M system." Thesis, Open University, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.316666.

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Davies, Graham Peter. "Motifs in the HsdR subunit of EcoKI necessary for ATP-dependent DNA translocation and DNA cleavage." Thesis, University of Edinburgh, 2000. http://hdl.handle.net/1842/13586.

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The type I restriction enzyme <i>Eco</i>KI specifies DNA methyltransferase, ATPase, DNA translocase and endonuclease activities. One subunit (HsdR) of the oligomeric enzyme contributes to those activities essential for restriction. These activities are thought to involve ATP-dependent DNA translocation and DNA cleavage. Analyses of recently predicted amino acid sequences of known and putative type I restriction endonucleases indicates conservation of eight amino acid motifs in the HsdR subunit. Seven are characteristics of the DEAD-box family of proteins that comprise known, or putative, helic
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Pan, Tianyuan [Verfasser], Edmund [Akademischer Betreuer] Maser та Sabine [Gutachter] Fuchs. "Isolation and identification of two repressors, TetR AND LuxR, FOR 3,17β-hsd and 3α-hsd/cr gene regulation in Comamonas testosteroni / Tianyuan Pan ; Gutachter: Sabine Fuchs ; Betreuer: Edmund Maser". Kiel : Universitätsbibliothek Kiel, 2019. http://d-nb.info/1202630332/34.

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Puigoriol, Illamola Dolors. "Stress influence in neurodegeneration. Unravelling the mechanisms underlying stress response in brain ageing by 11ß-HSD1 inhibition." Doctoral thesis, Universitat de Barcelona, 2020. http://hdl.handle.net/10803/671427.

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The world is facing an unprecedented situation: soon the number of people over 60 years old will exceed the number of children, and more people at extreme old age than ever before. This is due to medical advances that have increased life expectancy and with it, the number of elderly. The latest data published by the WHO predicts that by 2050 the world’s population aged 60 years and older is expected to nearly double from 12% to 22% achieving a total 2 billion, up from 900 million in 2015. A longer life brings with it opportunities, however, there is little evidence to suggest that older people
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Mbeko, Simaleko Marcel. "Efficacité d’interventions de prévention, basées sur une meilleure prise en compte des besoins perçus et vécus des HSH en République Centrafricaine." Doctoral thesis, Universite Libre de Bruxelles, 2020. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/316093.

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Résumé français :Problématique :les hommes qui ont des rapports sexuels avec des hommes (HSH) constituent les populations les plus à risque d’infection au VIH dans différents pays d’Afrique subsaharienne. A ce jour, très peu d’interventions sont menées pour réduire le risque d’infection en influant sur les facteurs de risque, en Afrique Centrale et particulièrement en République Centrafricaine. Les objectifs de cette thèse visent à démontrer que les HSH sont identifiables et sont à risque des IST/VIH, que leur simple suivi médical ne permet pas un changement de comportements sexuels et réduire
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Ketzner, Karissa Marie Wilson David A. "11[beta]-HSD₂ activity in an equine distal limb and thoracic wound model." Diss., Columbia, Mo. : University of Missouri-Columbia, 2009. http://hdl.handle.net/10355/6662.

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"December 2009" The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from PDF of title page (University of Missouri--Columbia, viewed on January 5, 2010). Thesis advisor: David A. Wilson. Includes bibliographical references.
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Trottier, Alexandre. "Étude de l'action du PBRM, un inhibiteur de la 17β-hydroxystéroïde déshydrogénase (17β--HSD) type 1 : ...qui mena à la découverte fortuite d'un 1er activateur de la 17β-HSD type 12". Master's thesis, Université Laval, 2014. http://hdl.handle.net/20.500.11794/25503.

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Les 17β-hydroxystéroïdes déshydrogénases (17β-HSD) sont un groupe de 15 enzymes connues avant tout pour leur rôle dans le métabolisme des hormones sexuelles. La 17β-HSD1 est responsable de la toute dernière étape dans la fabrication des estrogènes actifs. Cela en fait une cible intéressante pour traiter l’endométriose et le cancer du sein qui sont stimulées par ces hormones. Le dérivé stéroïdien PBRM, conçu dans notre laboratoire, est l’une des rares molécules ayant démontré une inhibition forte et spécifique de la 17β-HSD1. Lors des présents travaux, l’effet de l’inhibiteur s’est avéré irréve
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Guerra, Enriquez Guillermo José. "Factores conductuales y cognitivos asociados al riesgo de contraer VIH en un grupo de HSH." Bachelor's thesis, Pontificia Universidad Católica del Perú, 2017. http://tesis.pucp.edu.pe/repositorio/handle/123456789/9892.

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La presente investigación buscó describir los factores conductuales (conductas sexuales de riesgo) y factores cognitivos (conocimientos, actitudes negativas y positivas, susceptibilidad y autoeficacia percibida) asociados al contagio del VIH en un grupo de 56 hombres que tienen sexo con otros hombres (HSH). Ellos asisten a una ONG en Lima, con edades entre 20 y 54 años (DE= 29.95). Para el objetivo, se usó parte del Cuestionario Confidencial de Vida Sexual Activa (CCVSA) desarrollado por el Ministerio de Salud de Colombia con la colaboración de la Organización Panamericana de la Salud (O
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Bailey, Helen Victoria. "Drug design and novel anti-cancer therapeutics : inhibitors of 17β hydroxysteroid dehydrogenase type 3". Thesis, University of Bath, 2007. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.512267.

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Herein, we describe the design and synthesis of novel inhibitors of 17β-hydroxysteroid dehydrogenase type 3 which convert androstenedione into testosterone, which is then converted into dihydrotestosterone (DHT). This isozyme has been implicated in the growth of prostate cancer. Using an in silico pharmacophore model initial targets were planned, based around a diphenylether hydrophobic head linked to a 4-substituted piperidine ring. Over 45 compounds were synthesised and many show significant biological activity when evaluated in a 17β-HSD type 3 biological assay. The most potent compound in
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42

Zou, Xiantong. "The role of 11β-hydroxysteroid dehydrogenase type 1 in liver fibrosis and inflammation in non-alcoholic fatty liver disease". Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/18748.

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Non-alcoholic fatty liver disease (NAFLD) is a worldwide health problem which includes steatosis (triglyceride accumulation alone), non-alcoholic steatohepatitis (NASH, with liver inflammation), fibrosis, cirrhosis and hepatocellular carcinoma. Liver fibrosis, which is a reversible response, is the final phase of most chronic liver disease and is characterized by accumulation of extracellular matrix (ECM) from activated hepatic stellate cells (HSCs). Glucocorticoids (GCs) regulate many aspects of metabolism involved in NAFLD. Also, GCs limit HSC activation in vitro. Tissue GC levels are regula
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43

Fallou, Hélène. "Adsorption sur des tissus de carbone activé de micropolluants émergents à l'état de traces dans les eaux : Traitements multi-échelles et modélisation." Rennes, Ecole nationale supérieure de chimie, 2015. http://www.theses.fr/2015ENCR0027.

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Aujourd’hui, de nombreuses études ont montré la présence de micropolluants dans les eaux. Ces composés ne sont que partiellement éliminés par les procédés conventionnels de traitement des eaux. Les procédés d’adsorption montrent un potentiel intéressant pour éliminer ces polluants. Dans un premier temps, l’étude des capacités d’adsorption sur des tissus de carbone activé de 9 micropolluants émergents a été effectuée dans des réacteurs fermés agités, afin de déterminer les cinétiques et isothermes d’adsorption dans des conditions proches des conditions environnementales (C0 = 1 μg. L-1 et en pr
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44

Garcia, Roberto. "Fatores envolvidos nos comportamentos de omissão circunstancial e de recusa do uso do preservativo em homens que fazem sexo com homens." Pontifícia Universidade Católica de São Paulo, 2016. https://tede2.pucsp.br/handle/handle/19132.

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Submitted by Jailda Nascimento (jmnascimento@pucsp.br) on 2016-10-04T14:32:43Z No. of bitstreams: 1 Roberto Garcia.pdf: 4809301 bytes, checksum: d4e473a0adf83548a31acfe46f828f61 (MD5)<br>Made available in DSpace on 2016-10-04T14:32:43Z (GMT). No. of bitstreams: 1 Roberto Garcia.pdf: 4809301 bytes, checksum: d4e473a0adf83548a31acfe46f828f61 (MD5) Previous issue date: 2016-07-08<br>This study aimed to identify and understand factors involved in conducts of circumstantial omission and refusal of condom use with casual and/or stable partners by MSM living with HIV+; and as a specific objective,
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45

Adie, Jillian E. "Structure-based drug design of 11β-hydroxysteroid dehydrogenase type 1 inhibitors". Thesis, University of Edinburgh, 2010. http://hdl.handle.net/1842/4673.

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The enzyme 11β-Hydroxysteroid Dehydrogenase 1 (11β-HSD1) catalyses the intracellular biosynthesis of the active glucocorticoid cortisol. Tissue specific dysregulation of the enzyme has been implicated in the development of metabolic syndrome and other associated diseases. Experiments with transgenic mice and prototype inhibitors show that inhibition of 11β-HSD1 in visceral adipose tissue and liver leads to a resistance of diet-induced hyperglycemia and a favourable lipid and lipoprotein profile as compared to controls. 11β-HSD1 inhibition has thus been proposed as an effective strategy to decr
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46

Dudamel, Wilmer. "Modélisation et simulation de l'influence de la température lors de l'adsorption de micropolluants organiques par du charbon actif dans les eaux naturelles." Rennes 1, 2005. http://www.theses.fr/2005REN1S024.

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Le but de ce travail est la modélisation, intégrant l’effet de la température, des équilibres et des cinétiques d’adsorption compétitive des pesticides avec la matière organique naturelle (MON). Des expériences en corps pur à différentes températures ont permis de sélectionner un modèle d’équilibre adapté. Les équilibres en compétition ont pu être modélisés en utilisant la théorie de la solution adsorbée idéale (IAST) et le principe d’un composé fictif équivalent (EBC) représentant la MON. L’ajustement des simulations, par le modèle de la diffusion de surface homogène (HSDM) en association ave
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47

Abdullah, Ammara. "Inhibitors of cytochrome P450 enzymes CYP17 and 17β-HSD3 : their role in the treatment of hormone-dependent prostate and breast cancer". Thesis, Kingston University, 2012. http://eprints.kingston.ac.uk/25093/.

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Androgens play an important part in the initiation and progression of hormone-dependent prostate and breast cancer. These types of cancers can be treated by androgen ablation therapy. However, androgen ablation is associated with short (2-3 years) remission of the disease. Therefore therapies that inhibit the systemic biosynthesis of androgens, by targeting the P450 enzymes (CYP17 and 17-[beta]HSD type 3) which catalyse androgen biosynthesis, may represent a rational approach in the treatment of androgen-dependent cancer. Inhibitors of the enzyme CYP17: ketoconazole and liarozole, have been sh
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48

Yang, Fu. "Role and regulation of 11β-hydroxysteroid dehydrogenase in lung inflammation". Thesis, University of Edinburgh, 2010. http://hdl.handle.net/1842/4828.

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Glucocorticoids are steroid hormones that have potent anti-inflammatory actions. Endogenous glucocorticoid action is modulated by 11β-hydroxysteroid dehydrogenase (11β-HSD) which catalyses the interconversion of active glucocorticoids (cortisol, corticosterone) and intrinsically inert forms (cortisone, 11-dehydrocorticosterone). There are 2 isozymes; 11β-HSD type 1 regenerates active glucocorticoids in vivo whereas 11β-HSD type 2 inactivates glucocorticoids. Although 11β-HSD1 is highly expressed in the lung, its role there has been little explored. In this study, the expression and localizatio
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49

Garcia, Roberto. "A experiência de estigma e discriminação em homem que faz sexo com homens (HSH) vivendo com HIV." Pontifícia Universidade Católica de São Paulo, 2012. https://tede2.pucsp.br/handle/handle/15115.

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Made available in DSpace on 2016-04-28T20:38:06Z (GMT). No. of bitstreams: 1 Roberto Garcia.pdf: 3656242 bytes, checksum: bf0a4acdaa32cc9c59550a43e611dd9e (MD5) Previous issue date: 2012-05-09<br>Since its beginning, the Aids epidemic has established a series of social representations which hampers the daily life of men who have sex with men (MSM) living with HIV, who see themselves as doubly stigmatized due to their sexual orientation. The main objective of this study is observing the experience of stigma and discrimination in man who has sex with men living with HIV. With this ample target
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50

Vaz, Aura Maria de Morais. "Descoberta e desenvolvimento de inibidores da 17ß-HSD-1 potencialmente úteis no tratamento do cancro da mama." Master's thesis, Universidade da Beira Interior, 2012. http://hdl.handle.net/10400.6/1133.

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Capítulo I O cancro da mama é o cancro mais comum entre as mulheres. Neste contexto, diversos estudos evidenciam que entre 40 a 60% de todos os cancros da mama são considerados hormono-dependentes, dependendo principalmente de 17β-estradiol para o seu desenvolvimento. No corpo humano, este estrogénio é originado maioritariamente a partir da estrona, um estrogénio com baixa atividade estrogénica, pela ação da enzima 17β-hidroxiesteroide desidrogenase tipo 1 (17β-HSD-1). Como esta enzima se encontra em elevadas quantidades em tecidos cancerígenos dependentes de estrogénios e tem elevada seletiv
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