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Journal articles on the topic 'HSFA2'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Scharf, Klaus-Dieter, Harald Heider, Ingo Höhfeld, Ruth Lyck, Enrico Schmidt, and Lutz Nover. "The Tomato Hsf System: HsfA2 Needs Interaction with HsfA1 for Efficient Nuclear Import and May Be Localized in Cytoplasmic Heat Stress Granules." Molecular and Cellular Biology 18, no. 4 (1998): 2240–51. http://dx.doi.org/10.1128/mcb.18.4.2240.

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ABSTRACT In heat-stressed (HS) tomato (Lycopersicon peruvianum) cell cultures, the constitutively expressed HS transcription factor HsfA1 is complemented by two HS-inducible forms, HsfA2 and HsfB1. Because of its stability, HsfA2 accumulates to fairly high levels in the course of a prolonged HS and recovery regimen. Using immunofluorescence and cell fractionation experiments, we identified three states of HsfA2: (i) a soluble, cytoplasmic form in preinduced cultures maintained at 25°C, (ii) a salt-resistant, nuclear form found in HS cells, and (iii) a stored form of HsfA2 in cytoplasmic HS gra

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2

Heerklotz, Dirk, Pascal Döring, Frank Bonzelius, Sybille Winkelhaus, and Lutz Nover. "The Balance of Nuclear Import and Export Determines the Intracellular Distribution and Function of Tomato Heat Stress Transcription Factor HsfA2." Molecular and Cellular Biology 21, no. 5 (2001): 1759–68. http://dx.doi.org/10.1128/mcb.21.5.1759-1768.2001.

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ABSTRACT Tomato heat stress transcription factor HsfA2 is a shuttling protein with dominant cytoplasmic localization as a result of a nuclear import combined with an efficient export. Besides the nuclear localization signal (NLS) adjacent to the oligomerization domain, a C-terminal leucine-rich motif functions as a nuclear export signal (NES). Mutant forms of HsfA2 with a defective or an absent NES are nuclear proteins. The same is true for the wild-type HsfA2 if coexpressed with HsfA1 or in the presence of export inhibitor leptomycin B (LMB). Fusion of the NES domain of HsfA2 to HsfB1, which

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3

Ren, Shixiong, Kaibiao Ma, Zhaogeng Lu, et al. "Transcriptomic and Metabolomic Analysis of the Heat-Stress Response of Populus tomentosa Carr." Forests 10, no. 5 (2019): 383. http://dx.doi.org/10.3390/f10050383.

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Plants have evolved mechanisms of stress tolerance responses to heat stress. However, little is known about metabolic responses to heat stress in trees. In this study, we exposed Populus tomentosa Carr. to control (25 °C) and heat stress (45 °C) treatments and analyzed the metabolic and transcriptomic effects. Heat stress increased the cellular concentration of H2O2 and the activities of antioxidant enzymes. The levels of proline, raffinose, and melibiose were increased by heat stress, whereas those of pyruvate, fumarate, and myo-inositol were decreased. The expression levels of most genes (PS

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4

Zupanska, Agata, Collin LeFrois, Robert Ferl, and Anna-Lisa Paul. "HSFA2 Functions in the Physiological Adaptation of Undifferentiated Plant Cells to Spaceflight." International Journal of Molecular Sciences 20, no. 2 (2019): 390. http://dx.doi.org/10.3390/ijms20020390.

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Heat Shock Factor A2 (HsfA2) is part of the Heat Shock Factor (HSF) network, and plays an essential role beyond heat shock in environmental stress responses and cellular homeostatic control. Arabidopsis thaliana cell cultures derived from wild type (WT) ecotype Col-0 and a knockout line deficient in the gene encoding HSFA2 (HSFA2 KO) were grown aboard the International Space Station (ISS) to ascertain whether the HSF network functions in the adaptation to the novel environment of spaceflight. Microarray gene expression data were analyzed using a two-part comparative approach. First, genes diff

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5

Oh, Hye-Sook, Ora Son, Jong-Yoon Chun, et al. "The Bradyrhizobium japonicum hsfA Gene Exhibits a Unique Developmental Expression Pattern in Cowpea Nodules." Molecular Plant-Microbe Interactions® 14, no. 11 (2001): 1286–92. http://dx.doi.org/10.1094/mpmi.2001.14.11.1286.

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The Bradyrhizobium japonicum host-specific fixation gene hsfA was identified as essential for nitrogen fixation on cowpea, but not required for nitrogen fixation on soybean or siratro. The DNA sequence of the hsfA promoter contains a consensus RpoN, -24/-12 binding site, suggesting the involvement of a regulatory protein that binds to an upstream activating sequence (UAS). To further explore the regulation of this interesting gene, serial deletions of the hsfA promoter were made and fused with the β-glucuronidase (GUS) gene. The HsfA3 deletion, containing 60 bp 5′ of the -24/-12 sequence, show

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6

Jacob, Pierre, Gwilherm Brisou, Marion Dalmais, et al. "The Seed Development Factors TT2 and MYB5 Regulate Heat Stress Response in Arabidopsis." Genes 12, no. 5 (2021): 746. http://dx.doi.org/10.3390/genes12050746.

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HEAT SHOCK FACTOR A2 (HSFA2) is a regulator of multiple environmental stress responses required for stress acclimation. We analyzed HSFA2 co-regulated genes and identified 43 genes strongly co-regulated with HSFA2 during multiple stresses. Motif enrichment analysis revealed an over-representation of the site II element (SIIE) in the promoters of these genes. In a yeast 1-hybrid screen with the SIIE, we identified the closely related R2R3-MYB transcription factors TT2 and MYB5. We found overexpression of MYB5 or TT2 rendered plants heat stress tolerant. In contrast, tt2, myb5, and tt2/myb5 loss

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7

Enomoto, Takuo, Mutsutomo Tokizawa, Hiroki Ito, et al. "STOP1 regulates the expression of HsfA2 and GDHs that are critical for low-oxygen tolerance in Arabidopsis." Journal of Experimental Botany 70, no. 12 (2019): 3297–311. http://dx.doi.org/10.1093/jxb/erz124.

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Abstract The SENSITIVE TO PROTON RHIZOTOXICITY 1 (STOP1) transcription factor regulates gene expression associated with multiple stress tolerances in plant roots. In this study, we investigated the mechanism responsible for the sensitivity of the stop1 mutant to low-oxygen stress in Arabidopsis. Transcriptomic analyses revealed that two genes involved in low-oxygen tolerance, namely GLUTAMATE DEHYDROGENASE 1 (GDH1) and GDH2, showed lower expression levels in the stop1 mutant than in the wild-type. Sensitivity of the gdh1gdh2 double-mutant to low-oxygen conditions was partly attributable to the

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8

Singh, Garima, Neelam K. Sarkar, and Anil Grover. "Tango between Ethylene and HSFA2 Settles Heat Tolerance." Trends in Plant Science 26, no. 5 (2021): 429–32. http://dx.doi.org/10.1016/j.tplants.2021.03.003.

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9

Doring, Pascal, Eckardt Treuter, Catherine Kistner, Ruth Lyck, Alexander Chen, and Lutz Nover. "The Role of AHA Motifs in the Activator Function of Tomato Heat Stress Transcription Factors HsfA1 and HsfA2." Plant Cell 12, no. 2 (2000): 265. http://dx.doi.org/10.2307/3870927.

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10

Döring, Pascal, Eckardt Treuter, Catherine Kistner, Ruth Lyck, Alexander Chen, and Lutz Nover. "The Role of AHA Motifs in the Activator Function of Tomato Heat Stress Transcription Factors HsfA1 and HsfA2." Plant Cell 12, no. 2 (2000): 265–78. http://dx.doi.org/10.1105/tpc.12.2.265.

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11

Lämke, Jörn, Krzysztof Brzezinka, and Isabel Bäurle. "HSFA2 orchestrates transcriptional dynamics after heat stress inArabidopsis thaliana." Transcription 7, no. 4 (2016): 111–14. http://dx.doi.org/10.1080/21541264.2016.1187550.

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12

Xin, Haibo, Hua Zhang, Li Chen, et al. "Cloning and characterization of HsfA2 from Lily (Lilium longiflorum)." Plant Cell Reports 29, no. 8 (2010): 875–85. http://dx.doi.org/10.1007/s00299-010-0873-1.

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13

Chan-Schaminet, Kwan Yu, Sanjeev K. Baniwal, Daniela Bublak, Lutz Nover, and Klaus-Dieter Scharf. "Specific Interaction between Tomato HsfA1 and HsfA2 Creates Hetero-oligomeric Superactivator Complexes for Synergistic Activation of Heat Stress Gene Expression." Journal of Biological Chemistry 284, no. 31 (2009): 20848–57. http://dx.doi.org/10.1074/jbc.m109.007336.

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14

Werghi, Sirine, Charfeddine Gharsallah, Nishi Kant Bhardwaj, Hatem Fakhfakh, and Faten Gorsane. "Insights into the heat-responsive transcriptional network of tomato contrasting genotypes." Plant Genetic Resources: Characterization and Utilization 19, no. 1 (2021): 44–57. http://dx.doi.org/10.1017/s1479262121000083.

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AbstractDuring recent decades, global warming has intensified, altering crop growth, development and survival. To overcome changes in their environment, plants undergo transcriptional reprogramming to activate stress response strategies/pathways. To evaluate the genetic bases of the response to heat stress, Conserved DNA-derived Polymorphism (CDDP) markers were applied across tomato genome of eight cultivars. Despite scattered genotypes, cluster analysis allowed two neighbouring panels to be discriminate. Tomato CDDP-genotypic and visual phenotypic assortment permitted the selection of two con

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15

Banti, Valeria, Fabrizio Mafessoni, Elena Loreti, Amedeo Alpi, and Pierdomenico Perata. "The Heat-Inducible Transcription Factor HsfA2 Enhances Anoxia Tolerance in Arabidopsis." Plant Physiology 152, no. 3 (2010): 1471–83. http://dx.doi.org/10.1104/pp.109.149815.

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16

Liu, Junzhong, Lili Feng, Xueting Gu, et al. "An H3K27me3 demethylase-HSFA2 regulatory loop orchestrates transgenerational thermomemory in Arabidopsis." Cell Research 29, no. 5 (2019): 379–90. http://dx.doi.org/10.1038/s41422-019-0145-8.

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17

NISHIZAWA-YOKOI, Ayako, Eriko YOSHIDA, Yukinori YABUTA, and Shigeru SHIGEOKA. "Analysis of the Regulation of Target Genes by anArabidopsisHeat Shock Transcription Factor, HsfA2." Bioscience, Biotechnology, and Biochemistry 73, no. 4 (2009): 890–95. http://dx.doi.org/10.1271/bbb.80809.

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18

Kataoka, Ryo, Misato Takahashi, and Nobuhiro Suzuki. "Coordination between bZIP28 and HSFA2 in the regulation of heat response signals in Arabidopsis." Plant Signaling & Behavior 12, no. 11 (2017): e1376159. http://dx.doi.org/10.1080/15592324.2017.1376159.

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19

Liu, Jinjie, Na Sun, Meng Liu, et al. "An Autoregulatory Loop Controlling Arabidopsis HsfA2 Expression: Role of Heat Shock-Induced Alternative Splicing." Plant Physiology 162, no. 1 (2013): 512–21. http://dx.doi.org/10.1104/pp.112.205864.

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20

Cohen-Peer, Reut, Silvia Schuster, David Meiri, Adina Breiman, and Adi Avni. "Sumoylation of Arabidopsis heat shock factor A2 (HsfA2) modifies its activity during acquired thermotholerance." Plant Molecular Biology 74, no. 1-2 (2010): 33–45. http://dx.doi.org/10.1007/s11103-010-9652-1.

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21

Heerklotz, Dirk, Raffaella Calligaris, Sybille Winkelhaus, Marc Kirschner, Lutz Nover, and Klaus-Dieter Scharf. "NUCLEAR EXPORT AND INTERACTION WITH CYTOPLASMIC CHAPERONE COMPLEXES OF TOMATO HEAT STRESS TRANSCRIPTION FACTOR HSFA2." Biochemical Society Transactions 28, no. 5 (2000): A351. http://dx.doi.org/10.1042/bst028a351a.

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22

Charng, Yee-yung, Hsiang-chin Liu, Nai-yu Liu, et al. "A Heat-Inducible Transcription Factor, HsfA2, Is Required for Extension of Acquired Thermotolerance in Arabidopsis." Plant Physiology 143, no. 1 (2006): 251–62. http://dx.doi.org/10.1104/pp.106.091322.

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23

Evrard, Alexandre, Mukesh Kumar, David Lecourieux, Jessica Lucks, Pascal von Koskull-Döring, and Heribert Hirt. "Regulation of the heat stress response inArabidopsisby MPK6-targeted phosphorylation of the heat stress factor HsfA2." PeerJ 1 (April 2, 2013): e59. http://dx.doi.org/10.7717/peerj.59.

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24

Giorno, Filomena, Mieke Wolters-Arts, Stefania Grillo, Klaus-Dieter Scharf, Wim H. Vriezen, and Celestina Mariani. "Developmental and heat stress-regulated expression of HsfA2 and small heat shock proteins in tomato anthers." Journal of Experimental Botany 61, no. 2 (2009): 453–62. http://dx.doi.org/10.1093/jxb/erp316.

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25

Hu, Yangjie, Anida Mesihovic, José M. Jiménez‐Gómez, et al. "Natural variation in HsfA2 pre‐mRNA splicing is associated with changes in thermotolerance during tomato domestication." New Phytologist 225, no. 3 (2019): 1297–310. http://dx.doi.org/10.1111/nph.16221.

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26

Port, Markus, Joanna Tripp, Dirk Zielinski, et al. "Role of Hsp17.4-CII as Coregulator and Cytoplasmic Retention Factor of Tomato Heat Stress Transcription Factor HsfA2." Plant Physiology 135, no. 3 (2004): 1457–70. http://dx.doi.org/10.1104/pp.104.042820.

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27

Meiri, David, and Adina Breiman. "Arabidopsis ROF1 (FKBP62) modulates thermotolerance by interacting with HSP90.1 and affecting the accumulation of HsfA2-regulated sHSPs." Plant Journal 59, no. 3 (2009): 387–99. http://dx.doi.org/10.1111/j.1365-313x.2009.03878.x.

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28

Yu, Hai-Dong, Xiao-Fei Yang, Si-Ting Chen, et al. "Downregulation of Chloroplast RPS1 Negatively Modulates Nuclear Heat-Responsive Expression of HsfA2 and Its Target Genes in Arabidopsis." PLoS Genetics 8, no. 5 (2012): e1002669. http://dx.doi.org/10.1371/journal.pgen.1002669.

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29

Fragkostefanakis, Sotirios, Anida Mesihovic, Stefan Simm, et al. "HsfA2 Controls the Activity of Developmentally and Stress-Regulated Heat Stress Protection Mechanisms in Tomato Male Reproductive Tissues." Plant Physiology 170, no. 4 (2016): 2461–77. http://dx.doi.org/10.1104/pp.15.01913.

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30

Piveta, Leonard Bonilha, Nilda Roma-Burgos, José Alberto Noldin, et al. "Molecular and Physiological Responses of Rice and Weedy Rice to Heat and Drought Stress." Agriculture 11, no. 1 (2020): 9. http://dx.doi.org/10.3390/agriculture11010009.

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Rice is the staple food for about half of the world population. Rice grain yield and quality are affected by climatic changes. Arguably, rice cultivars’ genetic diversity is diminished from decades of breeding using narrow germplasm, requiring introgressions from other Oryza species, weedy or wild. Weedy rice has high genetic diversity, which is an essential resource for rice crop improvement. Here, we analyzed the phenotypic, physiological, and molecular profiles of two rice cultivars (IRGA 424 and SCS119 Rubi) and five weedy rice (WR), from five different Brazilian regions, in response to he

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Nishizawa-Yokoi, Ayako, Hitoshi Tainaka, Eriko Yoshida, Masahiro Tamoi, Yukinori Yabuta, and Shigeru Shigeoka. "The 26S Proteasome Function and Hsp90 Activity Involved in the Regulation of HsfA2 Expression in Response to Oxidative Stress." Plant and Cell Physiology 51, no. 3 (2010): 486–96. http://dx.doi.org/10.1093/pcp/pcq015.

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32

Masuda, Shinji, Yoshihito Tokaji, Yuichi Kobayashi, and Hiroyuki Ohta. "Mechanisms of induction of the stress-responsive transcription factors HsfA2 and DREB2A by 12-oxo-phytodienoic acid inArabidopsis thaliana." Bioscience, Biotechnology, and Biochemistry 78, no. 4 (2014): 647–50. http://dx.doi.org/10.1080/09168451.2014.891929.

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33

Baniwal, Sanjeev K., Kwan Yu Chan, Klaus-Dieter Scharf, and Lutz Nover. "Role of Heat Stress Transcription Factor HsfA5 as Specific Repressor of HsfA4." Journal of Biological Chemistry 282, no. 6 (2007): 3605–13. http://dx.doi.org/10.1074/jbc.m609545200.

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34

Zhang, Lingrui, Yinshu Li, Da Xing, and Caiji Gao. "Characterization of mitochondrial dynamics and subcellular localization of ROS reveal that HsfA2 alleviates oxidative damage caused by heat stress in Arabidopsis." Journal of Experimental Botany 60, no. 7 (2009): 2073–91. http://dx.doi.org/10.1093/jxb/erp078.

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35

Arofatullah, Nur Akbar, Morifumi Hasegawa, Sayuri Tanabata, Isao Ogiwara, and Tatsuo Sato. "Heat Shock-Induced Resistance Against Pseudomonas syringae pv. tomato (Okabe) Young et al. via Heat Shock Transcription Factors in Tomato." Agronomy 9, no. 1 (2018): 2. http://dx.doi.org/10.3390/agronomy9010002.

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*Abstract: We investigated the role of heat shock transcription factors (Hsfs) during induction of defense response by heat-shock treatment (HST) in tomato. Leaf disease symptoms were significantly reduced at 12 and 24 h after HST, consistent with upregulation of pathogenesis-related (PR) genes PR1a2 and PR1b1 peaking at 24 h after treatment. These genes were upregulated at the treatment application site, but not in untreated leaves. In contrast to HST, inoculation of the first leaf induced systemic upregulation of acidic PR genes in uninoculated second leaves. Furthermore, heat shock element

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36

Maleckova, Eva, Dominik Brilhaus, Thomas J. Wrobel, and Andreas P. M. Weber. "Transcript and metabolite changes during the early phase of abscisic acid-mediated induction of crassulacean acid metabolism in Talinum triangulare." Journal of Experimental Botany 70, no. 22 (2019): 6581–96. http://dx.doi.org/10.1093/jxb/erz189.

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Abstract Crassulacean acid metabolism (CAM) has evolved as a water-saving strategy, and its engineering into crops offers an opportunity to improve their water use efficiency. This requires a comprehensive understanding of the regulation of the CAM pathway. Here, we use the facultative CAM species Talinum triangulare as a model in which CAM can be induced rapidly by exogenous abscisic acid. RNA sequencing and metabolite measurements were employed to analyse the changes underlying CAM induction and identify potential CAM regulators. Non-negative matrix factorization followed by k-means clusteri

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37

Ogawa, D., K. Yamaguchi, and T. Nishiuchi. "High-level overexpression of the Arabidopsis HsfA2 gene confers not only increased themotolerance but also salt/osmotic stress tolerance and enhanced callus growth." Journal of Experimental Botany 58, no. 12 (2007): 3373–83. http://dx.doi.org/10.1093/jxb/erm184.

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38

Schramm, Franziska, Arnab Ganguli, Elke Kiehlmann, Gisela Englich, Daniela Walch, and Pascal von Koskull-Döring. "The Heat Stress Transcription Factor HsfA2 Serves as a Regulatory Amplifier of a Subset of Genes in the Heat Stress Response in Arabidopsis." Plant Molecular Biology 60, no. 5 (2006): 759–72. http://dx.doi.org/10.1007/s11103-005-5750-x.

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39

Nishizawa-Yokoi, Ayako, Ryota Nosaka, Hideki Hayashi, et al. "HsfA1d and HsfA1e Involved in the Transcriptional Regulation of HsfA2 Function as Key Regulators for the Hsf Signaling Network in Response to Environmental Stress." Plant and Cell Physiology 52, no. 5 (2011): 933–45. http://dx.doi.org/10.1093/pcp/pcr045.

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40

Chen, Xuan, Xiulian Yang, Jun Xie, et al. "Biochemical and Comparative Transcriptome Analyses Reveal Key Genes Involved in Major Metabolic Regulation Related to Colored Leaf Formation in Osmanthus fragrans ‘Yinbi Shuanghui’ during Development." Biomolecules 10, no. 4 (2020): 549. http://dx.doi.org/10.3390/biom10040549.

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Osmanthus fragrans ‘Yinbi Shuanghui’ not only has a beautiful shape and fresh floral fragrance, but also rich leaf colors that change, making the tree useful for landscaping. In order to study the mechanisms of color formation in O. fragrans ‘Yinbi Shuanghui’ leaves, we analyzed the colored and green leaves at different developmental stages in terms of leaf pigment content, cell structure, and transcriptome data. We found that the chlorophyll content in the colored leaves was lower than that of green leaves throughout development. By analyzing the structure of chloroplasts, the colored leaves

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41

Sojka, Damian Robert, Agnieszka Gogler-Pigłowska, Katarzyna Klarzyńska, et al. "HSPA2 Chaperone Contributes to the Maintenance of Epithelial Phenotype of Human Bronchial Epithelial Cells but Has Non-Essential Role in Supporting Malignant Features of Non-Small Cell Lung Carcinoma, MCF7, and HeLa Cancer Cells." Cancers 12, no. 10 (2020): 2749. http://dx.doi.org/10.3390/cancers12102749.

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Heat Shock Protein A2 (HSPA2) is a member of the HSPA (HSP70) chaperone family and has a critical role for male fertility. HSPA2 is present in a number of somatic organs. Limited evidence suggests that HSPA2 may be involved in regulating epithelial cell differentiation. HSPA2 also emerged as a cancer-related chaperone; however, no consensus on its functional significance has been reached so far. In this study, we compared the phenotypic effects of HSPA2 deficit in non-transformed human bronchial epithelial cells (HBEC), and in lung, breast, and cervical cancer cells. We used various techniques

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42

Filipczak, Piotr Teodor, Wojciech Piglowski, Magdalena Glowala-Kosinska, Zdzislaw Krawczyk, and Dorota Scieglinska. "HSPA2 overexpression protects V79 fibroblasts against bortezomib-induced apoptosis." Biochemistry and Cell Biology 90, no. 2 (2012): 224–31. http://dx.doi.org/10.1139/o11-083.

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Human HSPA2 is a member of the HSPA (HSP70) family of heat-shock proteins, encoded by the gene originally described as testis-specific. Recently, it has been reported that HSPA2 can be also expressed in human somatic tissues in a cell-type specific manner. The aim of the present study was to find out whether HSPA2 can increase the resistance of somatic cells to the toxic effect of heat shock, proteasome inhibitors, and several anticancer cytostatics. We used a Chinese hamster fibroblast V79 cell line because these cells do not express the HSPA2 and cytoprotective HSPA1 proteins under normal cu

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43

Goodson, M. L., O. K. Park-Sarge, and K. D. Sarge. "Tissue-dependent expression of heat shock factor 2 isoforms with distinct transcriptional activities." Molecular and Cellular Biology 15, no. 10 (1995): 5288–93. http://dx.doi.org/10.1128/mcb.15.10.5288.

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Heat shock factor 2 (HSF2) functions as a transcriptional regulator of heat shock protein gene expression in mammalian cells undergoing processes of differentiation and development. Our previous studies demonstrated high regulated expression and unusual constitutive DNA-binding activity of the HSF2 protein in mouse testes, suggesting that HSF2 functions to regulate heat shock protein gene expression in spermatogenic cells. The purpose of this study was to test whether HSF2 regulation in testes is associated with alterations in the HSF2 polypeptide expressed in testes relative to other mouse ti

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44

Sandqvist, Anton, Johanna K. Björk, Malin Åkerfelt, et al. "Heterotrimerization of Heat-Shock Factors 1 and 2 Provides a Transcriptional Switch in Response to Distinct Stimuli." Molecular Biology of the Cell 20, no. 5 (2009): 1340–47. http://dx.doi.org/10.1091/mbc.e08-08-0864.

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Organisms respond to circumstances threatening the cellular protein homeostasis by activation of heat-shock transcription factors (HSFs), which play important roles in stress resistance, development, and longevity. Of the four HSFs in vertebrates (HSF1-4), HSF1 is activated by stress, whereas HSF2 lacks intrinsic stress responsiveness. The mechanism by which HSF2 is recruited to stress-inducible promoters and how HSF2 is activated is not known. However, changes in the HSF2 expression occur, coinciding with the functions of HSF2 in development. Here, we demonstrate that HSF1 and HSF2 form heter

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45

Pigłowski, Wojciech, Radosława Nowak, Zdzisław Krawczyk, and Dorota Scieglińska. "The structural and functional analysis of the human HSPA2 gene promoter region." Acta Biochimica Polonica 54, no. 1 (2007): 99–106. http://dx.doi.org/10.18388/abp.2007_3274.

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HSPA2 is a human counterpart of the testis-specific rodent Hst70/Hsp70.2 gene. In contrast to the latter, the expression of the human HSPA2 gene is not limited to the testis, and recent data show that human tumor cells can express this gene at significant levels. The characteristics of HSPA2 expression suggests that it can influence the phenotype and survival of cancer cells similarly as overexpression of major members of the HSP70 gene family. Until now, neither the structure of the transcription unit of the human HSPA2 gene has been established nor a functional analysis of its promoter perfo

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46

Scieglinska, Dorota, Damian Robert Sojka, Agnieszka Gogler-Pigłowska, Vira Chumak, and Zdzisław Krawczyk. "Various Anti-HSPA2 Antibodies Yield Different Results in Studies on Cancer-Related Functions of Heat Shock Protein A2." International Journal of Molecular Sciences 21, no. 12 (2020): 4296. http://dx.doi.org/10.3390/ijms21124296.

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Heat shock proteins (HSPs) constitute a major part of the molecular chaperone system and play a fundamental role in cell proteostasis. The HSPA (HSP70) family groups twelve highly homologous HSPA proteins. Certain HSPAs are regarded as important cancer-related proteins, prospective therapeutic targets for cancer treatment, and also as potential cancer biomarkers. Heat Shock Protein A2 (HSPA2), a testis-enriched chaperone and one of the least characterized members of the HSPA family, has recently emerged as an important cancer-relevant protein with potential biomarker significance. Nevertheless

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47

Malumpong, C., S. Cheabu, C. Mongkolsiriwatana, W. Detpittayanan, and A. Vanavichit. "Spikelet fertility and heat shock transcription factor (Hsf) gene responses to heat stress in tolerant and susceptible rice (Oryza sativa L.) genotypes." Journal of Agricultural Science 157, no. 04 (2019): 283–99. http://dx.doi.org/10.1017/s002185961900056x.

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AbstractThe reproductive stage of rice is the most sensitive to heat stress, which can lead to spikelet sterility. Thus, heat-tolerant and heat-susceptible genotypes were used to investigate their differences in terms of phenotypic responses and expression changes of Hsf genes at the pre-flowering stage under heat stress. Results clearly showed that panicles had the highest temperature compared with other plant parts under both natural and heated conditions. However, the temperatures of tolerant and susceptible genotypes were not significantly different. In terms of spikelet fertility, the tol

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Shinkawa, Toyohide, Ke Tan, Mitsuaki Fujimoto, et al. "Heat shock factor 2 is required for maintaining proteostasis against febrile-range thermal stress and polyglutamine aggregation." Molecular Biology of the Cell 22, no. 19 (2011): 3571–83. http://dx.doi.org/10.1091/mbc.e11-04-0330.

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Heat shock response is characterized by the induction of heat shock proteins (HSPs), which facilitate protein folding, and non-HSP proteins with diverse functions, including protein degradation, and is regulated by heat shock factors (HSFs). HSF1 is a master regulator of HSP expression during heat shock in mammals, as is HSF3 in avians. HSF2 plays roles in development of the brain and reproductive organs. However, the fundamental roles of HSF2 in vertebrate cells have not been identified. Here we find that vertebrate HSF2 is activated during heat shock in the physiological range. HSF2 deficien

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Mathew, Anu, Sameer K. Mathur, and Richard I. Morimoto. "Heat Shock Response and Protein Degradation: Regulation of HSF2 by the Ubiquitin-Proteasome Pathway." Molecular and Cellular Biology 18, no. 9 (1998): 5091–98. http://dx.doi.org/10.1128/mcb.18.9.5091.

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ABSTRACT Mammalian cells coexpress a family of heat shock factors (HSFs) whose activities are regulated by diverse stress conditions to coordinate the inducible expression of heat shock genes. Distinct from HSF1, which is expressed ubiquitously and activated by heat shock and other stresses that result in the appearance of nonnative proteins, the stress signal for HSF2 has not been identified. HSF2 activity has been associated with development and differentiation, and the activation properties of HSF2 have been characterized in hemin-treated human K562 erythroleukemia cells. Here, we demonstra

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McMillan, D. Randy, Elisabeth Christians, Michael Forster, et al. "Heat Shock Transcription Factor 2 Is Not Essential for Embryonic Development, Fertility, or Adult Cognitive and Psychomotor Function in Mice." Molecular and Cellular Biology 22, no. 22 (2002): 8005–14. http://dx.doi.org/10.1128/mcb.22.22.8005-8014.2002.

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ABSTRACT Members of the heat shock factor (HSF) family are evolutionarily conserved regulators that share a highly homologous DNA-binding domain. In mammals, HSF1 is the main factor controlling the stress-inducible expression of Hsp genes while the functions of HSF2 and HSF4 are less clear. Based on its developmental profile of expression, it was hypothesized that HSF2 may play an essential role in brain and heart development, spermatogenesis, and erythroid differentiation. To directly assess this hypothesis and better understand the underlying mechanisms that require HSF2, we generated Hsf2 k

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