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Journal articles on the topic 'Hsp-70'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

SNOECKX, LUC H. E. H., RICHARD CORNELUSSEN, ROBERT S. RENEMAN, and GER J. VUSSE. "Windows for HSP 70." Annals of the New York Academy of Sciences 793, no. 1 Myocardial Pr (1996): 167–76. http://dx.doi.org/10.1111/j.1749-6632.1996.tb33513.x.

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2

Sahebari, M., K. Hashemzadeh, M. Mahmoudi, Z. Saremi, and Z. Mirfeizi. "Diagnostic Yield of Heat Shock Protein 70 (HSP-70) and Anti-HSP-70 in Behcet-Induced Uveitis." Scandinavian Journal of Immunology 77, no. 6 (2013): 476–81. http://dx.doi.org/10.1111/sji.12045.

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3

Mathew, A., A. Bell, and R. M. Johnstone. "Hsp-70 is closely associated with the transferrin receptor in exosomes from maturing reticulocytes." Biochemical Journal 308, no. 3 (1995): 823–30. http://dx.doi.org/10.1042/bj3080823.

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The presence of the heat shock protein (hsp-70) has been detected in exocytosed vesicles (which are named exosomes) from mammalian and avian immature red cells (i.e. reticulocytes) as well as from a differentiating avian erythroleukaemic cell line. The close, but non-covalent, association of hsp-70 with the transferrin receptor (TFR) in exosomes is demonstrated by: (1) the ability to cross-link hsp-70 to TFR; (2) the co-immunoprecipitation of hsp-70 and TFR with an antibody against TFR, and the co-immunoprecipitation of TFR and hsp-70 with antibody against hsp-70; and (3) the retention of TFR

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4

Heikkila, J. J., N. Ovsenek, and P. Krone. "Examination of heat shock protein mRNA accumulation in early Xenopus laevis embryos." Biochemistry and Cell Biology 65, no. 2 (1987): 87–94. http://dx.doi.org/10.1139/o87-013.

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Elevation of the incubation temperature of Xenopus laevis neurulae from 22 to 33–35 °C induced the accumulation of heat shock protein (hsp) 70 mRNA (2.7 kilobases (kb)) and a putative hsp 87 mRNA (3.2 kb). While constitutive levels of both hsp mRNAs were detectable in unfertilized eggs and cleavage-stage embryos, heat-induced accumulation was not observed until after the mid-blastula stage. Exposure of Xenopus laevis embryos to other stressors, such as sodium arsenite or ethanol, also induced a developmental stage-dependent accumulation of hsp 70 mRNA. To characterize the effect of temperature

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RUCKER, NATALIE, ANGELA FERRARIO, and CHARLES J. GOMER. "Constitutive overexpression of HSP-70 in thermal resistant tumor cells does not alter sensitivity to porphyrin-, chlorin-, or purpurin-mediated PDT." Journal of Porphyrins and Phthalocyanines 05, no. 02 (2001): 143–46. http://dx.doi.org/10.1002/jpp.322.

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Cellular expression of the 70 kDa heat shock protein (HSP-70) is observed following hyperthermia and is correlated with transient resistance to subsequent heating. Photodynamic therapy (PDT) mediated oxidative stress can also induce transcriptional and translational expression of a variety of genes including HSP-70. However, PDT-mediated HSP-70 expression can vary as a function of photosensitizer type and incubation conditions. In the current study we used three clinically relevant photosensitizers, a porphyrin (Photofrin), a purpurin (SnET2), and a chlorin (NPe6), to examine PDT-mediated HSP-

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6

Krone, P. H., and J. J. Heikkila. "Expression of microinjected hsp 70/CAT and hsp 30/CAT chimeric genes in developing Xenopus laevis embryos." Development 106, no. 2 (1989): 271–81. http://dx.doi.org/10.1242/dev.106.2.271.

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The expression of microinjected chimeric genes containing Drosophila hsp 70 and Xenopus hsp 70 and hsp 30 promoters linked to the reporter gene coding for bacterial chloramphenicol acetyltransferase (CAT) was examined during early development of Xenopus laevis. Heat-inducible expression of fusion genes containing either the Drosophila hsp 70 promoter (1100 bp) or the Xenopus hsp 70 promoter (750 bp) was first detectable after the midblastula stage of development. This coincides with the embryonic stage at which the endogenous hsp 70 gene is first heat-inducible. A Xenopus hsp 30/CAT fusion gen

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7

Preneta, Rachel, K. G. Papavinasasundaram, Alain J. Cozzone, and Bertrand Duclos. "Autophosphorylation of the 16 kDa and 70 kDa antigens (Hsp 16·3 and Hsp 70) of Mycobacterium tuberculosis." Microbiology 150, no. 7 (2004): 2135–41. http://dx.doi.org/10.1099/mic.0.26789-0.

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Several antigens of Mycobacterium tuberculosis, identified by monoclonal antibodies, have been previously cloned and are being exploited in the development of improved vaccines and diagnostic reagents. In this study, the molecular characteristics of two of these antigens, the immunodominant proteins Hsp 16·3 and Hsp 70, were analysed in further detail by assessing their capacity to undergo protein phosphorylation, a chemical modification frequently used by organisms to adjust to environmental variations. Hsp 16·3 was overproduced in an Escherichia coli expression system and purified to homogen

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8

Pagliuso, Delaney C., Devavrat M. Bodas, and Amy E. Pasquinelli. "Recovery from heat shock requires the microRNA pathway in Caenorhabditis elegans." PLOS Genetics 17, no. 8 (2021): e1009734. http://dx.doi.org/10.1371/journal.pgen.1009734.

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The heat shock response (HSR) is a highly conserved cellular process that promotes survival during stress. A hallmark of the HSR is the rapid induction of heat shock proteins (HSPs), such as HSP-70, by transcriptional activation. Once the stress is alleviated, HSPs return to near basal levels through incompletely understood mechanisms. Here, we show that the microRNA pathway acts during heat shock recovery in Caenorhabditis elegans. Depletion of the miRNA Argonaute, Argonaute Like Gene 1 (ALG-1), after an episode of heat shock resulted in decreased survival and perdurance of high hsp-70 levels

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9

Eckert, Volker, Lidya Sanchez, Alan Cochrane, and Vincenzo Enea. "Plasmodium cynomolgi: The hsp 70 gene." Experimental Parasitology 75, no. 3 (1992): 323–28. http://dx.doi.org/10.1016/0014-4894(92)90217-x.

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10

Krone, P. H., and J. J. Heikkila. "Analysis of hsp 30, hsp 70 and ubiquitin gene expression in Xenopus laevis tadpoles." Development 103, no. 1 (1988): 59–67. http://dx.doi.org/10.1242/dev.103.1.59.

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Heat-induced accumulation of hsp 30 mRNA (1.1 kb) during early development of Xenopus laevis was first detectable at the tailbud stage (stage 30–34). This contrasts with heat-induced accumulation of hsp 70 mRNA (2.7 kb) and ubiquitin mRNA (size range = 1.7–3.1 kb), which was first detectable at the mid- to late-blastula stage. Continuous exposure of tadpoles to a 33 degrees C heat shock resulted in a coordinate, transient accumulation of hsp 30, hsp 70 and ubiquitin mRNA. A coordinate, temporal pattern was also observed for the decay of hsp 30, hsp 70 and ubiquitin mRNA in tadpoles recovering

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11

Sheikh-Hamad, D., A. Garcia-Perez, J. D. Ferraris, E. M. Peters, and M. B. Burg. "Induction of gene expression by heat shock versus osmotic stress." American Journal of Physiology-Renal Physiology 267, no. 1 (1994): F28—F34. http://dx.doi.org/10.1152/ajprenal.1994.267.1.f28.

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Elevated temperature rapidly increases expression of genes for heat shock proteins (HSP), including HSP-70. The response is presumably triggered by denaturation of cell proteins and helps in their renaturation. Hypertonicity may also denature proteins, but the protective response, which is accumulation of compatible organic osmolytes [including betaine and inositol in Madin-Darby canine kidney (MDCK) cells], apparently differs and is slow. Recently, hypertonicity was found also to increase expression of HSP-70 in MDCK cells, a response proposed to provide protection until organic osmolytes can

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12

Darasch, S., D. D. Mosser, N. C. Bols, and J. J. Heikkila. "Heat shock gene expression in Xenopus laevis A6 cells in response to heat shock and sodium arsenite treatments." Biochemistry and Cell Biology 66, no. 8 (1988): 862–70. http://dx.doi.org/10.1139/o88-098.

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Continuous exposure of a Xenopus laevis kidney epithelial cell line, A6, to either heat shock (33 °C) or sodium arsenite (50 μM) resulted in transient but markedly different temporal patterns of heat-shock protein (HSP) synthesis and HSP 70 and 30 mRNA accumulation. Heat-shock-induced synthesis of HSPs was detectable within 1 h and reached maximum levels by 2–3 h. While sodium arsenite induced the synthesis of some HSPs within 1 h, maximal HSP synthesis did not occur until 12 h. The pattern of HSP 70 and 30 mRNA accumulation was similar to the response observed at the protein level. During rec

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13

Brown, C. R., R. L. Martin, W. J. Hansen, R. P. Beckmann, and W. J. Welch. "The constitutive and stress inducible forms of hsp 70 exhibit functional similarities and interact with one another in an ATP-dependent fashion." Journal of Cell Biology 120, no. 5 (1993): 1101–12. http://dx.doi.org/10.1083/jcb.120.5.1101.

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Mammalian cells constitutively express a cytosolic and nuclear form of heat shock protein (hsp) 70, referred to here as hsp 73. In response to heat shock or other metabolic insults, increased expression of another cytosolic and nuclear form of hsp 70, hsp 72, is observed. The constitutively expressed hsp 73, and stress-inducible hsp 72, are highly related proteins. Still unclear, however, is exactly why most eukaryotic cells, in contrast to prokaryotic cells, express a novel form of hsp 70 (i.e., hsp 72) after experiencing stress. To address this question, we prepared antibodies specific to ei

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14

Welsh, Frank A., Donald J. Moyer, and Valerie A. Harris. "Regional Expression of Heat Shock Protein-70 mRNA and c-Fos mRNA following Focal Ischemia in Rat Brain." Journal of Cerebral Blood Flow & Metabolism 12, no. 2 (1992): 204–12. http://dx.doi.org/10.1038/jcbfm.1992.30.

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In situ hybridization was used to estimate regional levels of heat shock protein-70 (HSP-70) mRNA and c-fos mRNA in two related models of focal cerebral ischemia. In the first model, permanent occlusion of the distal middle cerebral artery (MCA) alone caused a patchy increase in HSP-70 mRNA by 1 h in the central zone of the MCA territory of the ipsilateral neocortex. Tissue levels of HSP-70 mRNA continued to increase for several hours and remained elevated at 24 h. In contrast to the focal expression of HSP-70, c-fos mRNA was increased throughout the ipsilateral cerebral cortex by 15 min and r

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15

Biutifasari, Verna. "Heat Shock Protein (HSP) 70 dalam apoptosis dan inflamasi." Surabaya Biomedical Journal 1, no. 3 (2022): 213–20. http://dx.doi.org/10.30649/sbj.v1i3.35.

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Semua organisme menunjukkan respon homeostasis ketika organisme tersebut mengalami perubahan yang cepat dalam lingkungannya. Kemampuan organisme untuk beradaptasi atau menyesuaikan diri dengan lingkungan barunya sangat penting untuk kelangsungan hidup, dan kemungkinan merupakan kekuatan pendorong integral dalam evolusi. Heat shock protein (Hsp) adalah kelompok protein yang ekspresinya meningkat sebagai respons terhadap injuri. Hsp berfungsi sebagai molekul chaperone, degradasi protein, menghambat apoptosis. Peningkatan kadar Hsp terjadi setelah stres. Hsp mempunyai peran sentral dalam homeosta

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16

Setiawan, Meddy, and Fitriana Yulanda. "The Extract of Purple Sweet Potato Against Heat-Shock Protein 70 Expression in White Male Rat of Atherosclerosis Model." Majalah Obat Tradisional 26, no. 3 (2021): 169. http://dx.doi.org/10.22146/mot.66254.

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Shock protein 70 (Hsp-70) molecule is pro-inflammatory mediator cytokine that trigger atherosclerosis. The purple sweet potato has many natural antioxidants such as flavonoids (anthocyanins) and is valuable for reducing Hsp-70 expression due to its antioxidant content.This study aims to determine the effect of purple sweet potato (Ipoema batatas L.) extract in reducing the Hsp-70 levels in the white male rat atherosclerosis model.This study was a posttest-only control group design with normality, homogeneity, ANOVA, post hoc test, correlation, and regression tests. There were five groups in th

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17

Heikkila, J. J., S. P. Darasch, D. D. Mosser, and N. C. Bols. "Heat and sodium arsenite act synergistically on the induction of heat shock gene expression in Xenopus laevis A6 cells." Biochemistry and Cell Biology 65, no. 4 (1987): 310–16. http://dx.doi.org/10.1139/o87-040.

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Heat shock protein (HSP) synthesis was studied in the Xenopus epithelial cell line A6 in response to heat and sodium arsenite, either singly or together. Temperatures of 33–35 °C consistently brought about the synthesis of HSPs at 87,73,70,54,31, and 30 kilodaltons (kDa), whereas sodium arsenite at 25–100 μM induced the synthesis of HSPs at 73 and 70 kDa. In cultures exposed to 10 μM sodium arsenite at 30 °C, HSP synthesis in the 68- to 73-kDa and 29- to 31-kDa regions was much greater than the HSP synthesis in response to each treatment individually. RNA dot blot analysis using homologous gen

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18

Savastano, Marina, Marilena Celadin, Marina Pittoni, Mario Plebani, and Gino Marioni. "Western Blot Immunoassay for HSP-70 Antibodies in Idiopathic Tinnitus: A Preliminary Report." Annals of Otology, Rhinology & Laryngology 115, no. 3 (2006): 243–46. http://dx.doi.org/10.1177/000348940611500314.

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Objectives: Our preliminary study investigated the role of nonspecific immunologic tests and immunoassay for heat shock protein 70 (HSP-70) in supporting the possibility of an autoimmune inner ear process determining idiopathic tinnitus. Methods: Thirty-six consecutive patients with idiopathic tinnitus without other otologic or autoimmune diseases and 20 healthy blood donor subjects underwent determinations of circulating immune complexes (CICs) and other nonspecific immunologic factors and immunoassay for HSP-70. Results: The mean CIC values were 4.2 μg/mL in the tinnitus patients and 0.9 μg/

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19

Lund, Susan G., Mervyn E. A. Lund, and Bruce L. Tufts. "Red blood cell Hsp 70 mRNA and protein as bio-indicators of temperature stress in the brook trout (Salvelinus fontinalis)." Canadian Journal of Fisheries and Aquatic Sciences 60, no. 4 (2003): 460–70. http://dx.doi.org/10.1139/f03-039.

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The purpose of this study was to examine the heat shock protein (Hsp) 70 mRNA and protein response in several tissues of Miramichi brook trout (Salvelinus fontinalis) under both acute and extended heat stress conditions to determine the utility of the red blood cell (rbc) heat shock response as a biomarker of sublethal temperature stress. Red blood cells consistently produced one of the highest responses of all of the tissues examined. Recovery of Hsp 70 mRNA following acute temperature increase required between 24 h and 48 h. In contrast, Hsp 70 protein levels remained significantly elevated

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20

Albanidou-Farmaki, E., D. Andreadis, A. Poulopoulos, K. Farmakis, and A. Markopoulos. "Serum levels of Heat Shock Protein-70 in Patients with Oral Lichen Planus." Balkan Journal of Dental Medicine 18, no. 2 (2014): 106–8. http://dx.doi.org/10.1515/bjdm-2015-0017.

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SUMMARYUsually increased presence of Heat Shock Proteins (HSPs) is considered to mediate inflammation process in Oral Lichen Planus (OLP) lesions, but in contrast HSP-70 expression found to be stable or even decreased in those lesions. The purpose of this study was to detect the serum titres of the HSP-70 in patients with OLP compared to healthy individuals, which may indicate an alternative, systemic role. Serum levels of HSP-70 were detected by sandwich-ELISA in 45 patients with reticular (n=28) and erosive (n=17) OLP, respectively. A group of 35 healthy individuals was used as control. HSP-

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21

Armstead, William M., and James G. Hecker. "Heat shock protein modulation of KATPand KCachannel cerebrovasodilation after brain injury." American Journal of Physiology-Heart and Circulatory Physiology 289, no. 3 (2005): H1184—H1190. http://dx.doi.org/10.1152/ajpheart.00276.2005.

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Fluid percussion brain injury (FPI) impairs pial artery dilation to activators of the ATP-sensitive (KATP) and calcium-activated (KCa) K+channels. This study investigated the role of heat shock protein (HSP) in the modulation of K+channel-induced pial artery dilation after FPI in newborn pigs equipped with a closed cranial window. Under nonbrain injury conditions, topical coadministration of exogenous HSP-27 (1 μg/ml) blunted dilation to cromakalim, CGRP, and NS-1619 (10−8and 10−6M; cromakalim and CGRP are KATPagonists and NS-1619 is a KCaagonist). In contrast, coadministration of exogenous HS

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Yuan, C. M., E. M. Bohen, F. Musio, and M. A. Carome. "Sublethal heat shock and cyclosporine exposure produce tolerance against subsequent cyclosporine toxicity." American Journal of Physiology-Renal Physiology 271, no. 3 (1996): F571—F578. http://dx.doi.org/10.1152/ajprenal.1996.271.3.f571.

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Sublethal heat shock has been shown to produce tolerance in cells and tissues subsequently exposed to heat or ischemia/ATP depletion. We tested whether heating LLC-PK1 cells for 2 h at 42 degrees C induced heat shock protein-70 (HSP-70) gene expression and conferred tolerance against subsequent cyclosporine A (CyA) toxicity. HSP-70 mRNA was increased immediately after heat shock, returning to baseline by 4 h. HSP-70 protein increased by 1 h after heat shock and declined thereafter, approaching baseline after 72 h. Cells heat shocked at 4 and 24 h prior to CyA exposure were significantly more v

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Ku, Z., J. Yang, V. Menon, and D. B. Thomason. "Decreased polysomal HSP-70 may slow polypeptide elongation during skeletal muscle atrophy." American Journal of Physiology-Cell Physiology 268, no. 6 (1995): C1369—C1374. http://dx.doi.org/10.1152/ajpcell.1995.268.6.c1369.

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Slowed elongation rate is the apparent cause of the rapid decrease in rat soleus muscle protein synthesis rate during non-weight bearing. We found that elongation factor 2 was not phosphorylated and thus could not explain the slowed elongation rate. However, we observed a 44 +/- 19 and 28 +/- 14% decrease in the chaperone protein 70-kDa heat-shock cognate/heat shock protein (HSC/HSP-70) associated with the polysomes after 12 and 18 h of non-weight bearing, respectively. Size-fractionated polysomes had less HSC/HSP-70 associated with the larger polysomes in 18-h non-weight-bearing soleus muscle

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Alder, G. M., B. M. Austen, C. L. Bashford, A. Mehlert, and C. A. Pasternak. "Heat shock proteins induce pores in membranes." Bioscience Reports 10, no. 6 (1990): 509–18. http://dx.doi.org/10.1007/bf01116611.

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Human heat shock protein (hsp) 70 and bacterial protein groEL promote leakage of calcein from liposomes induced by human serum albumin signal peptide, by S. aureus α toxin or by diphtheria toxin. Hsp 70 and groEL, as well as two mycobacterial homologues hsp 71 and hsp 65, induce ion conducting pores across planar lipid bilayers at low or neutral pH. It is concluded that hsp induce pores in membranes and that this may contribute to their action within cells.

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Derebery, M. Jennifer. "Prevalence of Heat Shock Protein in Patients with Meniere's Disease and Allergy." Otolaryngology–Head and Neck Surgery 126, no. 6 (2002): 677–82. http://dx.doi.org/10.1067/mhn.2002.125297.

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OBJECTIVE: The study purpose was to investigate the prevalence of elevated heat shock protein 70 (HSP-70) in patients with Meniere's disease who have milk allergy compared with those who are not allergic to milk. METHODS: Fifty-five patients with Meniere's disease and allergy in whom milk allergy had been confirmed by intradermal progressive dilutional food testing or skin testing to milk antigen were included. Blood serum was tested for HSP-70 elevation with a Western blot assay using bovine renal extract. The 29 women and 26 men ranged in age from 29 to 76 years (mean age 52.8 years). Forty

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Beckmann, RP, M. Lovett, and WJ Welch. "Examining the function and regulation of hsp 70 in cells subjected to metabolic stress." Journal of Cell Biology 117, no. 6 (1992): 1137–50. http://dx.doi.org/10.1083/jcb.117.6.1137.

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Members of the heat-shock protein (hsp) 70 family, distributed within various cellular compartments, have been implicated in facilitating protein maturation events. In particular, related hsp 70 family members appear to bind nascent polypeptides which are in the course of synthesis and/or translocation into organelles. We previously reported that in normal, unstressed cells, cytosolic hsp 70 (hsp 72/73) interacted transiently with nascent polypeptides. We suspect that such interactions function to prevent or slow down the folding of the nascent polypeptide chain. Once synthesis is complete, an

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Hauser, P??ter, Zolt??n Hanz??ly, Zsuzsanna Jakab, et al. "Expression and Prognostic Examination of Heat Shock Proteins (HSP 27, HSP 70, and HSP 90) in Medulloblastoma." Journal of Pediatric Hematology/Oncology 28, no. 7 (2006): 461–66. http://dx.doi.org/10.1097/01.mph.0000212954.35727.ad.

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Van Why, S. K., F. Hildebrandt, T. Ardito, A. S. Mann, N. J. Siegel, and M. Kashgarian. "Induction and intracellular localization of HSP-72 after renal ischemia." American Journal of Physiology-Renal Physiology 263, no. 5 (1992): F769—F775. http://dx.doi.org/10.1152/ajprenal.1992.263.5.f769.

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To determine whether heat shock proteins (HSPs) might be active in cellular recovery following transient ischemia, we examined rat kidneys for 70-kDa HSP (HSP-70) mRNA expression, protein elaboration, and intracellular localization after 45 min of renal ischemia and reflow of 15 min, 2, 6, and 24 h. Inducible HSP-70 mRNA is present at 15 min of reperfusion, peaks between 2 and 6 h, and falls by 24 h. Inducible 72-kDa HSP (HSP-72) protein accumulates progressively through 24 h and is found in both soluble and microsomal fractions following ischemia. Within proximal tubules, immunofluorescent lo

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Widelitz, R. B., B. E. Magun, and E. W. Gerner. "Effects of cycloheximide on thermotolerance expression, heat shock protein synthesis, and heat shock protein mRNA accumulation in rat fibroblasts." Molecular and Cellular Biology 6, no. 4 (1986): 1088–94. http://dx.doi.org/10.1128/mcb.6.4.1088-1094.1986.

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A single hyperthermic exposure can render cells transiently resistant to subsequent high temperature stresses. Treatment of rat embryonic fibroblasts with cycloheximide for 6 h after a 20-min interval at 45 degrees C inhibits protein synthesis, including heat shock protein (hsp) synthesis, and results in an accumulation of hsp 70 mRNA, but has no effect on subsequent survival responses to 45 degrees C hyperthermia. hsp 70 mRNA levels decreased within 1 h after removal of cycloheximide but then appeared to stabilize during the next 2 h (3 h after drug removal and 9 h after heat shock). hsp 70 m

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Widelitz, R. B., B. E. Magun, and E. W. Gerner. "Effects of cycloheximide on thermotolerance expression, heat shock protein synthesis, and heat shock protein mRNA accumulation in rat fibroblasts." Molecular and Cellular Biology 6, no. 4 (1986): 1088–94. http://dx.doi.org/10.1128/mcb.6.4.1088.

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A single hyperthermic exposure can render cells transiently resistant to subsequent high temperature stresses. Treatment of rat embryonic fibroblasts with cycloheximide for 6 h after a 20-min interval at 45 degrees C inhibits protein synthesis, including heat shock protein (hsp) synthesis, and results in an accumulation of hsp 70 mRNA, but has no effect on subsequent survival responses to 45 degrees C hyperthermia. hsp 70 mRNA levels decreased within 1 h after removal of cycloheximide but then appeared to stabilize during the next 2 h (3 h after drug removal and 9 h after heat shock). hsp 70 m

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Zuhri, Mohamad Nurdin, Nurwasis Nurwasis, Endang Retnowati, and Windhu Purnomo. "Difference of Heat Shock Protein 70 Serum Level Between Primary Angle Closure Glaucoma and Open Angle Glaucoma Patients: Indonesia Single Center Experience." Folia Medica Indonesiana 57, no. 3 (2021): 205. http://dx.doi.org/10.20473/fmi.v57i3.23601.

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This study aimed to analyze the differences in Hsp 70 serum levels in patients with primary angle-closure compared to patients with open-angle glaucoma at Dr. Soetomo General Academic Hospital, Surabaya, East Java. This cross-sectional study was conducted on 41 subjects divided into 2 groups consisting of 21 patients with primary angle-closure glaucoma and 20 patients with open-angle glaucoma. Anterior segment examination was assessed by slit-lamp biomicroscope examination. Intraocular pressure on both eyes was measured by Perkin’s tonometry. Posterior segment examination was performed with 78

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Fadel, Ahmed. "Immunological and Comparative Study of Serum HSP-70 Level and MicroRNA-21 Expression with Clinical Findings in Patients with Diabetic Nephropathy." Al-Kufa University Journal for Biology 17, no. 1 (2025): 92–98. https://doi.org/10.36320/ajb/v17.i1.19255.

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Diabetic nephropathy is an important cause of morbidity and mortality in all types of diabetes. MicroRNA-21 expression can be induced by hypoxic conditions such as kidney injury and regulated in kidney diseases and may be used as a diagnostic biomarker in kidney diseases. On the other hand, in most people with nephropathy, heat shock protein (HSP 70) has been investigated from different aspects in experimental studies. HSP-70 is the most abundant form of HSP in cells. HSP-70 is involved in the response to various acute and chronic conditions in the kidney as well as other urinary tract infecti

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Gade, Nitin, R. K. Mahapatra, Arvind Sonawane, V. K. Singh, Ramesh Doreswamy, and Mohini Saini. "Molecular Characterization of Heat Shock Protein 70-1 Gene of Goat (Capra hircus)." Molecular Biology International 2010 (June 29, 2010): 1–7. http://dx.doi.org/10.4061/2010/108429.

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Heat shock protein 70 (HSP 70) plays a vital role by bestowing cytoprotection against diverse kinds of stresses. The ubiquitous HSP 70 proteins are the most abundant and temperature sensitive among all the HSPs. The present paper has characterized HSP70-1 cDNA in goat (Capra hircus). Total RNA isolated from goat peripheral blood mononuclear cells was reverse transcribed to cDNA that was used for amplification of HSP 70-1 gene. PCR product (1926 bp) was cloned in pGEM-T easy vector and sequenced. Sequence analysis revealed 1926-bp-long open reading frame of HSP 70-1 gene encoding 641 amino acid

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Kukreja, R. C., M. C. Kontos, K. E. Loesser, et al. "Oxidant stress increases heat shock protein 70 mRNA in isolated perfused rat heart." American Journal of Physiology-Heart and Circulatory Physiology 267, no. 6 (1994): H2213—H2219. http://dx.doi.org/10.1152/ajpheart.1994.267.6.h2213.

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Ischemia/reperfusion (I/R) and preconditioning of the heart by coronary artery occlusions increase expression of heat shock protein 70 (HSP 70). Because free radicals are generated during I/R, we hypothesized that the oxidant stress might contribute to an increased expression of HSP 70. Isolated rat hearts were perfused with free radical-generating systems such as xanthine/xanthine oxidase (X/XO), irradiated rose bengal (RB) generating singlet oxygen, and H2O2 for 15 min followed by 30 min of recovery period. Significant decrease in developed pressure and coronary flow occurred after perfusion

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Dix, David J. "Hsp 70 expression and function during gametogenesis." Cell Stress & Chaperones 2, no. 2 (1997): 73. http://dx.doi.org/10.1379/1466-1268(1997)002<0073:heafdg>2.3.co;2.

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Bielecka-Dabrowa, Agata, Marcin Barylski, Dimitri P. Mikhailidis, Jacek Rysz, and Maciej Banach. "HSP 70 and atherosclerosis – protector or activator?" Expert Opinion on Therapeutic Targets 13, no. 3 (2009): 307–17. http://dx.doi.org/10.1517/14728220902725149.

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Marquez, Carol M., Penny K. Sneed, Gloria C. Li, Johnson Y. Mak, and Theodore L. Phillips. "HSP 70 synthesis in clinical hyperthermia patients." International Journal of Radiation Oncology*Biology*Physics 19 (January 1990): 121. http://dx.doi.org/10.1016/0360-3016(90)90649-5.

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Indra, Syarif, Umul Khair, and Yulia Trisna. "Blood Pressure and Heat Shock Protein 70 Levels Related to Acute Ischemic Stroke Severity." Green Medical Journal 2, no. 2 (2020): 49–55. http://dx.doi.org/10.33096/gmj.v2i2.55.

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Introduction: Hypertension is a risk factor of ischemic stroke, the prevalence of ischemic stroke in Indonesia is 34.1%. Heat Shock Protein (HSP) 70 increases in hypertension and acute phase of ischemic stroke. To determine differences of blood pressure (BP) and HSP 70 levels, related to the acute ischemic stroke severity. Methods: This was a cross-sectional study that was carried out in the Neurological Ward of Dr.M.Djamil Hospital and National Stroke Hospital, from May to September 2019. Inclusion criteria were obtained consecutively. BP was measured with a sphygmomanometer, stroke sev

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Suwardewa, Tjokorda G. A., Ketut Surya Negara, Anak Agung Ngurah Anantasika, I. Wayan Artana Putra, I. Gde Sastra Winata, and Piere Emanuel Yoltuwu. "Kadar heat shock protein 70 (HSP 70) yang tinggi pada serum ibu sebagai faktor risiko persalinan preterm." Intisari Sains Medis 13, no. 1 (2022): 181–84. http://dx.doi.org/10.15562/ism.v13i1.1329.

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Introduction: Preterm birth defined as parturition that occurs less than 37 completed weeks of gestation is still being a big problem in obstetrics, especially in perinatology. Preterm delivery is one of the most common causes of neonatal morbidity and mortality. This study examined serum HSP 70 levels as a risk factor for preterm delivery.Method: The research design was analytic with a case-control method at Sanglah Hospital from February to June 2021. The samples were divided into two groups which are in the case group was 30 samples and the control group was 30 samples. In both groups, HSP

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Kanazawa, Yusei, Hajime Isomoto, Mikio Oka, et al. "Expression of Heat Shock Protein (Hsp) 70 and Hsp 40 in Colorectal Cancer." Medical Oncology 20, no. 2 (2003): 157–64. http://dx.doi.org/10.1385/mo:20:2:157.

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Isomoto, Hajime, Mikio Oka, Yoshitsugu Yano, et al. "Expression of heat shock protein (Hsp) 70 and Hsp 40 in gastric cancer." Cancer Letters 198, no. 2 (2003): 219–28. http://dx.doi.org/10.1016/s0304-3835(03)00305-7.

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Loshaj-Shala, Aida, Ana Poceva Panovska, Katerina Brezovska, Giangiacomo Beretta, Ljubica Suturkova, and Slobodan Apostolski. "Involvement of serum HSP 70 in Guillain-Barré Syndrome: An exploratory study and a review of current literature." Macedonian Pharmaceutical Bulletin 61, no. 01 (2015): 61–67. http://dx.doi.org/10.33320/maced.pharm.bull.2015.61.01.008.

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The evolutionary conserved family of heat shock proteins (HSP) is responsible for protecting cells against different types of stress. Although the levels of HSP can be readily measured in serum, the levels of HSP 70 in patients Guillain-Barre Syndrome (GBS) have not been studied before. To this aim we investigate whether patients with GBS (n=21) had altered serum HSP 70 levels compared to healthy controls (HC, n=9) and to patients affected by other immune disorders such as multifocal motor neuropathy (MMN, n=4) and chronic inflammatory demyelinating polyneuropathy (CIDP, n=6). The highest HSP

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Blumenfeld, Ken S., Frank A. Welsh, Valerie A. Harris, and Michael A. Pesenson. "Regional Expression of c-Fos and Heat Shock Protein-70 mRNA following Hypoxia-Ischemia in Immature Rat Brain." Journal of Cerebral Blood Flow & Metabolism 12, no. 6 (1992): 987–95. http://dx.doi.org/10.1038/jcbfm.1992.136.

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Cerebral ischemia induces the expression of a number of proteins that may have an important influence on cellular injury. The purpose of this study was to compare the regional effects of hypoxia–ischemia on the expression of the proto-oncogene, c-fos, and the heat shock protein-70 (HSP-70) gene in developing brain. Unilateral hypoxia–ischemia was produced in the brain of immature rats (7, 15, and 23 days after birth) using a combination of carotid artery ligation and systemic hypoxia (8% O2). After recovery for 2 and 24 h, the regional expression of c-fos and HSP-70 mRNA was determined using i

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Dudani, Anil K., Jelica Mehic, and Anthony Martyres. "Interaction of Plasminogen and Angiostatin with Heat Shock Proteins." Blood 108, no. 11 (2006): 1622. http://dx.doi.org/10.1182/blood.v108.11.1622.1622.

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Abstract Previous studies from this laboratory have demonstrated that plasminogen and angiostatin bind to endothelial cell (EC) surface-associated actin via their kringles in a specific manner. Heat shock proteins (hsps) like hsp 27 are constitutively expressed by vascular ECs and regulate actin polymerization, cell growth and migration. Since many hsps have also been found to be highly abundant on cell surfaces and there is evidence that bacterial surface hsps may interact with human plasminogen, the purpose of this study was to determine whether human plasminogen and angiostatin would intera

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Musial, Kinga, Krystyna Szprynger, Maria Szczepańska, and Danuta Zwolińska. "The Heat Shock Protein Profile in Children with Chronic Kidney Disease." Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis 30, no. 2 (2010): 227–32. http://dx.doi.org/10.3747/pdi.2008.00153.

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ObjectivesChronic kidney disease (CKD) due to inflammation, lipid disorders, and endothelial dysfunction predisposes to accelerated atherosclerosis. Elevated levels of heat shock proteins (HSPs) and antibodies against them have been described in adults with atherosclerotic lesions and cardiovascular events. However, there are no investigations of these variables in children with CKD treated conservatively or on peritoneal dialysis. Therefore, we decided to evaluate the profile of HSPs and their potential role as markers of atherosclerosis in these groups of patients.MethodsThe study group cons

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Lund, Susan G., Daniel Caissie, Richard A. Cunjak, Mathilakath M. Vijayan, and Bruce L. Tufts. "The effects of environmental heat stress on heat-shock mRNA and protein expression in Miramichi Atlantic salmon (Salmo salar) parr." Canadian Journal of Fisheries and Aquatic Sciences 59, no. 9 (2002): 1553–62. http://dx.doi.org/10.1139/f02-117.

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This study combines laboratory experiments with temperature monitoring and fish sampling in the wild to determine if Atlantic salmon (Salmo salar) parr from the Miramichi River in New Brunswick are currently experiencing significant sublethal heat stress during the warm summer months. Laboratory experiments indicated that Hsp 70 mRNA and protein and Hsp 30 mRNA were all significantly induced in Atlantic salmon parr between 22°C and 25°C. Field sampling during moderate spring temperatures and a high-temperature event in summer further indicated that the threshold for mRNA induction of both Hsp

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Hunaifi, Ilsa, Andi Kurnia Bintang, Jumraini Tammasse, et al. "MLC 901 Decreases HSP-70, MMP-9, Cerebral Infarction Volume and Functional Outcome in Acute Ischemic Stroke Rat Model." Indonesian Biomedical Journal 17, no. 3 (2025): 252–62. https://doi.org/10.18585/inabj.v17i3.3610.

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BACKGROUND: Acute ischemic stroke (AIS) is usually treated with thrombolysis, however the percentage of patients receiving this therapy is not quite low. Therefore, it is necessary to find alternative therapy using neuroprotective agent such as Moleac (MLC) 901. Heat shock proteins (HSP)-70 and matrix metalloproteinase (MMP)-9 are usually related to AIS due to the triggered stroke-induced physiological stress. However, the effect of MLC 901 on Hsp70 mRNA expression, HSP-70 and MMP-9 remains unclear. This study was conducted to determine the effect of MLC 901 on those three parameters in relati

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Eldine, Mostafa Kamal, Amr Aly Elshormisily, Eman Ali Tolbah, Mamdouh Mahmoud Mahdi, and Maged Refaat. "Heat shock protein 70 (HSP-70) levels in chronic spontaneous urticaria." International Journal of Medicine Sciences 4, no. 1 (2022): 1–5. http://dx.doi.org/10.33545/26648881.2022.v4.i1a.30.

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Deguchi, Yasuhiro, and Susumu Kishimoto. "Elevated expression of heat-shock protein gene in the fibroblasts of patients with scleroderma." Clinical Science 78, no. 4 (1990): 419–22. http://dx.doi.org/10.1042/cs0780419.

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1. Scleroderma is a systemic autoimmune disorder characterized by fibrosis affecting the skin, lung, kidney and other organs. The 70 kDa heat-shock protein has been implicated as essential for cell function during cell growth and differentiation. To study the molecular basis of intracellular events in sclerotic fibroblasts, we compared the expression of the hsp 70 gene in sclerotic and normal control fibroblasts by a run on nuclear transcription assay and a Northern blot assay. 2. In the run on nuclear transcription assay, sclerotic fibroblasts expressed an approximately eightfold higher level

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Subadi, Imam, Hening Laswati, and Harjanto JM. "HUBUNGAN EKSPRESI HSP 70 DAN EKSPRESI RESEPTOR OPIOID MU PADA PENURUNAN NYERI TERAPI BEKAM BASAH." Jurnal NERS 11, no. 1 (2016): 34. http://dx.doi.org/10.20473/jn.v11i12016.34-39.

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Latar belakang. Terapi bekam basah banyak digunakan untuk mengurangi nyeri, namun mekanisme penurunan nyeri terapi bekam basah belum jelas. Peregangan dan tusukan pada terapi bekam basah menimbulkan stres pada sel. Sel yang mengalami stres mengekspresikan HSP 70 dan reseptor opioid mu.Tujuan penelitian. Penelitian ini bertujuan membuktikan korelasi peningkatan ekspresi HSP 70 dan peningkatan reseptor opioid mu pasca terapi bekam basah.Bahan dan Metode. Jenis penelitian ini adalah penelitian eksperimental dengan rancangan randomized control group post test only design. Dua puluh empat tikus jen

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