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Journal articles on the topic 'HSP-90 alpha'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Anand, Athira Vimala, and Sukumaran. "ANTINEOPLASTIC EFFICACY OF SMILAX WIGHTII A.DC. (SMILACACEAE) AND ITS STEROIDAL SAPOGENINS: IN VITRO TO IN SILICO APPROACHES." Journal of Applied Biological Sciences 16, no. 1 (2022): 1–12. https://doi.org/10.5281/zenodo.5823038.

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Competency of plant metabolites and derivatives as antineoplastic drugs has been validated by modern medicine and the screening of flora for anticancer agents is crucial in drug discovery. <em>Smilax wightii </em>A.DC. (Smilacaceae) is an ethnomedicinal plant endemic to Western Ghats of India. The methanolic extract of various plant parts were subjected to investigation of antiproliferative potential. Dalton’s lymphoma Ascites (DLA), Ehrlich-Lettre ascites carcinoma (EAC), rat spleen, mouse fibroblast (L929) and human lung cancer (A549) cell lines were employed in the analysis. Stem extr

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Piura, Ettie, and Benjamin Piura. "Autoantibodies to Tumor-Associated Antigens in Breast Carcinoma." Journal of Oncology 2010 (2010): 1–14. http://dx.doi.org/10.1155/2010/264926.

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Autoantibodies (AAbs) to tumor-associated antigens (TAAs) have been identified in the circulation of patients with cancer. This paper will focus on recent knowledge related to circulating AAbs to TAAs in breast carcinoma. So far, the following TAAs have been identified to elicit circulating AAbs in breast carcinoma: p53, MUC-1, heat shock proteins (HSP-27, HSP-60, and HSP-90), HER2/neu/c-erb B2, GIPC-1, c-myc, c-myb, cancer-testis antigens (NY-ESO-1), BRCA1, BRCA2, endostatin, lipophilin B, cyclin B1, cyclin D1, fibulin, insulin-like growth factor binding protein 2 (IGFBP-2), topoisomerase II

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Anand, Athira Vimala, and Swapna T. Sukumaran. "ANTINEOPLASTIC EFFICACY OF SMILAX WIGHTII A.DC. (SMILACACEAE) AND ITS STEROIDAL SAPOGENINS: IN VITRO TO IN SILICO APPROACHES." Journal of Applied Biological Sciences 16, no. 1 (2022): 1–12. https://doi.org/10.71336/jabs.837.

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. Competency of plant metabolites and derivatives as antineoplastic drugs has been validated by modern medicine and the screening of flora for anticancer agents is crucial in drug discovery. Smilax wightii A.DC. (Smilacaceae) is an ethnomedicinal plant endemic to Western Ghats of India. The methanolic extract of various plant parts were subjected to investigation of antiproliferative potential. Dalton’s lymphoma Ascites (DLA), Ehrlich-Lettre ascites carcinoma (EAC), rat spleen, mouse fibroblast (L929) and human lung cancer (A549) cell lines were employed in the analysis. Stem extract exhibited

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Schmidt, J. A., and E. Abdulla. "Down-regulation of IL-1 beta biosynthesis by inducers of the heat-shock response." Journal of Immunology 141, no. 6 (1988): 2027–34. http://dx.doi.org/10.4049/jimmunol.141.6.2027.

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Abstract The effect of heat on IL-1 beta biosynthesis was investigated in both THP-1 cells, a myelomonocytic cell line which can be induced to make IL-1 alpha and beta, and human peripheral blood adherent monocytes (PBMC). Induction of THP-1 cells with LPS at 39 to 41 degrees C for 2 to 4 h resulted in the expected increased synthesis of the heat-shock proteins hsp 70 and hsp 90 but decreased synthesis of the IL-1 beta precursor protein, p35 (and its mRNA), compared with control cells at 37 degrees C. This appeared to be a direct effect on p35 synthesis rather than a block in LPS induction bec

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Eschricht, S., K. U. Jarr, C. Kuhn, H. Katus, N. Frey, and E. Chorianopoulos. "Calcineurin A stabilizes hypoxia-inducible factor-1 alpha via a heat shock protein (HSP) 90 dependent mechanism in myocardial hypertrophy." European Heart Journal 34, suppl 1 (2013): 37. http://dx.doi.org/10.1093/eurheartj/eht307.37.

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WU, W. "Differential effects of labor on heat shock protein (Hsp) 90 $alpha; and $beta; mRNA expression in the pregnant sheep uterus." Journal of the Society for Gynecologic Investigation 3, no. 2 (1996): 101A. http://dx.doi.org/10.1016/1071-5576(96)82532-9.

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Løken, S. B., I. Skrede, and T. Schumacher. "The Helvella corium species aggregate in Nordic countries – phylogeny and species delimitation." Fungal Systematics and Evolution 5, no. 1 (2020): 169–86. http://dx.doi.org/10.3114/fuse.2020.05.11.

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Mycologists have always been curious about the elaborate morphotypes and shapes of species of the genus Helvella. The small, black, cupulate Helvella specimens have mostly been assigned to Helvella corium, a broadly defined morpho-species. Recent phylogenetic analyses, however, have revealed an aggregate of species hidden under this name. We performed a multispecies coalescent analysis to re-assess species limits and evolutionary relationships of the Helvella corium species aggregate in the Nordic countries. To achieve this, we used morphology and phylogenetic evidence from five loci – heat sh

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Wang, Wenxiang, Ce Yang, Jing Xia, Ning Li, and Wei Xiong. "Luteolin is a potential inhibitor of COVID-19: An in silico analysis." Medicine 102, no. 38 (2023): e35029. http://dx.doi.org/10.1097/md.0000000000035029.

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The severe respiratory syndrome 2019 novel coronavirus disease (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread explosively, raising global health concerns. Luteolin shows antiviral properties, but its effect on SARS-CoV-2 and the associated mechanisms are not elucidated. We used network pharmacology, molecular docking and molecular dynamics to provide potential molecular support of luteolin (3,4,5,7-tetrahydroxyflavone) (LUT) against COVID-19. We employed network pharmacology, molecular docking, and molecular dynamics techniques to investigate h

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Suzuki, Mizuho, Kyosuke Takeshita, Yuki Kitamura, et al. "In Vitro Exposure to Glucose Alters the Expression of Phosphorylated Proteins in Platelets." Biomedicines 11, no. 2 (2023): 543. http://dx.doi.org/10.3390/biomedicines11020543.

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Diabetes mellitus (DM) is a pro-thrombotic state that can potentially cause serious cardiovascular complications. Platelet hyperactivation plays an important role in these pathological processes, however there is little or no information on the effect of hyperglycemia on platelet proteins. The aim of this study was to identify the molecular targets associated with platelet reactivity under hyperglycemia. Towards this goal, we examined the effects of the exposure of platelets to 1 and 2 h glucose (300 mg/dL) and control (vehicle and osmolality control using mannitol) on platelet proteins (n = 4

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Tissing, Wim, Jules P. P. Meijerink, Monique L. den Boer, Bas Brinkhof, and Rob Pieters. "RNA Expression Levels of (Co)Chaperone Molecules of the Glucocorticoid Receptor Are Not Related to In Vitro Prednisolone Resistance in Childhood ALL." Blood 104, no. 11 (2004): 4485. http://dx.doi.org/10.1182/blood.v104.11.4485.4485.

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Abstract In vitro resistance to Glucocorticoids (GC) is an important adverse risk factor in the treatment of ALL. To induce apoptosis in ALL cells, GC have to bind to the GC receptor (hGR), which is tightly regulated by various (co)chaperone molecules. HSP70, ST13 and HSP40 facilitate hGR binding to HSP90 and HOP in an energy dependent fashion. This complex is stabilised by immunophillins FKBP 51, FKBP59, CYP40 and P23 and is necessary for the hGR to be able to bind GC. The ATPase BAG1 can function as negative regulator of HSP70, and may downregulate hGR activity. After the GC-hGR complex is f

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Long, Chengyan, Yang Yang, Yong Yang, et al. "The Exploration of Novel Pharmacophore Characteristics and Multidirectional Elucidation of Structure-Activity Relationship and Mechanism of Sesquiterpene Pyridine Alkaloids from Tripterygium Based on Computational Approaches." Evidence-Based Complementary and Alternative Medicine 2021 (March 24, 2021): 1–14. http://dx.doi.org/10.1155/2021/6676470.

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Sesquiterpene pyridine alkaloids are a large group of highly oxygenated sesquiterpenoids, which are characterized by a macrocyclic dilactone skeleton containing 2-(carboxyalkyl) nicotinic acid and dihydro-β-agarofuran sesquiterpenoid, and are believed to be the active and less toxic components of Tripterygium. In this study, 55 sesquiterpene pyridine alkaloids from Tripterygium were subjected to identification of pharmacophore characteristics and potential targets analysis. Our results revealed that the greatest structural difference of these compounds was in the pyridine ring and the pharmaco

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Yi, Robin C., Maya Akbik, Logan R. Smith, Yael Klionsky, and Steven R. Feldman. "Therapeutic Advancements in Psoriasis and Psoriatic Arthritis." Journal of Clinical Medicine 14, no. 4 (2025): 1312. https://doi.org/10.3390/jcm14041312.

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Background: Within the past few years, many new therapies have emerged for psoriasis and psoriatic arthritis (PsA). Current topical therapies—including corticosteroids, vitamin D analogs, tapinarof, and roflumilast—remain the mainstay for mild disease, while oral systemic and biologic options are for moderate to severe cases. Biologics—such as Tumor necrosis factor-alpha (TNF-alpha), Interleukin 12/23 (IL-12/23), Interleukin-17 (IL-17), and Interleukin-23 (IL-23)—have revolutionized care by providing highly effective and safer alternatives. Oral small molecules, including Janus kinase (JAK) an

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Yi, Kaiyan, Yaning Zhou, Ming Zhang, and Yijun Guo. "The Core Mechanism of Yiqi Yangjing Decoction Inhibiting Nonsmall-Cell Lung Cancer." Evidence-Based Complementary and Alternative Medicine 2022 (May 9, 2022): 1–20. http://dx.doi.org/10.1155/2022/2256671.

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Background. Yiqi Yangjing prescription (YQYJ) is a traditional Chinese medicine prescription used for treating lung cancer. It has a significant effect on enhancing efficacy, reducing toxic symptoms, and improving patients’ physical well-being. The effective inhibitory effect on nonsmall-cell lung cancer (NSCLC) has been demonstrated in vitro and in vivo. However, the mechanism of action and the material basis still remain unclear. Methods. In this study, we explored this mechanism using network pharmacology, after which we explored the pharmacodynamics and the action mechanism of YQYJ using c

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Xia, Lu-yun, Zheng Luo, Han-piao Xu, et al. "Decoding Hippophae rhamnoides’ action of mechanism in Sjögren’s syndrome: A network pharmacology and molecular docking study." Quality Assurance and Safety of Crops & Foods 15, no. 1 (2023): 207–50. http://dx.doi.org/10.15586/qas.v15i1.1210.

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This study aimed to decode the potential bioactive compounds and action mechanism of Hippophae rhamnoides in treating Sjögren’s syndrome using network pharmacology and molecular docking approach. The Traditional Chinese Medicine Systematic Pharmacology Database and Analysis Platform (TCMSP) and HERB (a High--throughput Experiment- and Reference-guided database of TCM) database were used to identify the active components of -Hippophae rhamnoides and their targets. Databases, including GeneCards, Online Mendelian Inheritance (OMIM), and DisGeNET, were used to acquire the major targets of action

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Khan, Ruby, Bakht Pari, and Krzysztof Puszynski. "Comprehensive Bioinformatic Investigation of TP53 Dysregulation in Diverse Cancer Landscapes." Genes 15, no. 5 (2024): 577. http://dx.doi.org/10.3390/genes15050577.

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P53 overexpression plays a critical role in cancer pathogenesis by disrupting the intricate regulation of cellular proliferation. Despite its firmly established function as a tumor suppressor, elevated p53 levels can paradoxically contribute to tumorigenesis, influenced by factors such as exposure to carcinogens, genetic mutations, and viral infections. This phenomenon is observed across a spectrum of cancer types, including bladder (BLCA), ovarian (OV), cervical (CESC), cholangiocarcinoma (CHOL), colon adenocarcinoma (COAD), diffuse large B-cell lymphoma (DLBC), esophageal carcinoma (ESCA), h

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16

Rao, Rekha, Warren Fiskus, Ramesh Balusu, et al. "Treatment with Histone Deacetylase 6-Specific Inhibitor WT-161 Disrupts hsp90 Function, Abrogates Aggresome Formation and Sensitizes Human Mantle Cell Lymphoma Cells to Lethal ER Stress Induced by Proteasome Inhibitor Carfilzomib." Blood 116, no. 21 (2010): 2856. http://dx.doi.org/10.1182/blood.v116.21.2856.2856.

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Abstract Abstract 2856 The proteasome inhibitor bortezpmib has been shown to markedly increase the intracellular levels of misfolded proteins, induce aggresome formation and cause endoplasmic reticulum (ER) stress, resulting in apoptosis of human Mantle Cell Lymphoma (MCL) cells. Consistent with this, Bortezomib displays clinical efficacy in patients with relapsed and refractory MCL. We have recently reported that the pan-histone deacetylase (HDAC) inhibitor panobinostat, by also inhibiting HDAC6, abrogates aggresome formation and induces Endoplasmic Stress (ER) stress, as well as potentiates

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Gazitt, Yair, Cagla Akay, and Fatih Kircelli. "Synergy between 17 AAG and Arsenic Trioxide in the Induction of Apoptosis in Myeloma Cell Lines." Blood 106, no. 11 (2005): 5055. http://dx.doi.org/10.1182/blood.v106.11.5055.5055.

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Abstract Arsenic trioxide (ATO) is an effective chemotherapeutic agent for the treatment of acute promyelocytic leukemia and is being tested in phase II studies in various types of hematological malignancies and solid tumors. We have previously shown that ATO is a potent inducer of apoptosis in multiple myeloma cells, engaging primarily the intrinsic apoptotic pathway in cells expressing w.t. p53. In contrast, in cells expressing mutant p53, both the intrinsic and extrinsic apoptotic pathways are engaged. These findings were further supported by a recent study using a p53 temperature sensitive

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Eckhardt, Erika P., and Jongkyoo Kim. "78 Prolonged heat stress impact on molecular responses of skeletal muscle and growth performance in finishing beef steers." Journal of Animal Science 102, Supplement_3 (2024): 223–24. http://dx.doi.org/10.1093/jas/skae234.260.

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Abstract Rising temperatures significantly impact cattle production economically, reducing feed intake, efficiency, and growth, leading to substantial losses. Despite these known effects, there remains a paucity of data on the specific responses of skeletal muscle and adipose tissue to heat stress conditions. Therefore, this study aimed to elucidate the effects of prolonged heat stress on the molecular mechanisms of skeletal muscle growth and adipose tissue deposition and physiological response. Thirty-two predominantly Angus beef steers [initial average body weight (BW) = 364 ± 4.60 kg] were

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Galea-Lauri, J., A. J. Richardson, D. S. Latchman, and D. R. Katz. "Increased heat shock protein 90 (hsp90) expression leads to increased apoptosis in the monoblastoid cell line U937 following induction with TNF-alpha and cycloheximide: a possible role in immunopathology." Journal of Immunology 157, no. 9 (1996): 4109–18. http://dx.doi.org/10.4049/jimmunol.157.9.4109.

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Abstract In this study, we examined the hypothesis that heat shock proteins (hsp) (such as hsp72 and hsp90) are implicated in the regulation of forms of cell injury that lead to programmed cell death. The monoblastoid cell line U937 has been used as a model system. For hsp90, which is not heat inducible in this cell line, we used stable U937 transfectants that either hyperexpress or hypoexpress the protein. For hsp72 (which is reproducibly induced in all three cell lines to relatively high levels of expression), we studied U937 cells before and after heat shock. We showed that apoptosis does o

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Elliott, A., J. Waddington, R. Zhou, et al. "POS0870 PROTEIN BIOMARKERS ASSOCIATED WITH ENTHESITIS IN PSORIATIC ARTHRITIS." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 740.1–741. http://dx.doi.org/10.1136/annrheumdis-2023-eular.1660.

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BackgroundThe presence of enthesitis in PsA may provide clues to disease pathogenesis, aid diagnosis and contribute to poor prognosis. Ultrasound is an invaluable tool in assessing entheseal disease, but it requires training and is time consuming. We investigated whether enthesitis may be measured by changes in serum proteins and as such allow us to better understand, diagnose and treat the condition.ObjectivesTo use mass spectrometry (MS) based proteomics to identify protein biomarkers that may be associated with those PsA patients who suffer from enthesitis.MethodsSerum was collected as part

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Sipoloni, Victor Menezes, João Victor Silva‐Silva, Elthon G. Ferreira, et al. "Rotenoids from the Roots of Vicia faba L. (Fabaceae): Structural Characterization, Cytotoxic Effects, and Molecular Docking." Chemistry & Biodiversity, May 26, 2025. https://doi.org/10.1002/cbdv.202501091.

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ABSTRACTThe chemical study of the ethanolic extract from the roots of Vicia faba led to the isolation of two isoflavonoids, alfalone and 8‐O‐methylretusine, as well as a mixture of rotenoids, including clitoriacetal and clitoriacetal B, the latter of which is reported for the first time. These compounds were characterized through nuclear magnetic resonance and vibrational circular dichroism spectroscopies, and density functional theory calculations. The rotenoid mixture exhibited cytotoxic activity against HCT‐116, MCF‐7, and 501Mel cell lines, while showing no significant toxicity to NIH/3T3

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Lee, Yee Qian, Pathmanathan Rajadurai, Faridah Abas, Iekhsan Othman, and Rakesh Naidu. "Proteomic Analysis on Anti-Proliferative and Apoptosis Effects of Curcumin Analog, 1,5-bis(4-Hydroxy-3-Methyoxyphenyl)-1,4-Pentadiene-3-One-Treated Human Glioblastoma and Neuroblastoma Cells." Frontiers in Molecular Biosciences 8 (April 30, 2021). http://dx.doi.org/10.3389/fmolb.2021.645856.

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Curcumin analogs with excellent biological properties have been synthesized to address and overcome the poor pharmacokinetic profiles of curcumin. This study aims to investigate the cytotoxicity, anti-proliferative, and apoptosis-inducing ability of curcumin analog, MS13 on human glioblastoma U-87 MG, and neuroblastoma SH-SY5Y cells, and to examine the global proteome changes in these cells following treatment. Our current findings showed that MS13 induced potent cytotoxicity and anti-proliferative effects on both cells. Increased caspase-3 activity and decreased bcl-2 concentration upon treat

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Piredda, Maria Liliana, Girish Gaur, Gianfranco Catalano, et al. "PML/RARA inhibits expression of HSP90 and its target AKT." December 10, 2018. https://doi.org/10.1111/bjh.15715.

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SummaryEssential for cell survival, the 90 kD Heat Shock Proteins (HSP90) are molecular chaperons required for conformational stabilization and trafficking of numerous client proteins. Functional HSP90 is required for the stability of AKT, a serine‐threonine kinase phosphorylated in response to growth factor stimulation. AKT plays a crucial regulatory role in differentiation, cell cycle, transcription, translation, metabolism and apoptosis. Acute promyelocytic leukaemia (APL) is characterized by the presence of the promyelocytic leukaemia/retinoic acid receptor alpha (PML/RARA) fusion protein,

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Fang, Linkai, Xubin Hao, Chiduo Xu, et al. "HSP 90‐Alpha and Serotransferrin as Potential Biomarkers for Predicting IL‐17 Inhibitor Response in Non‐Radiographic Axial Spondyloarthritis: A Retrospective Analysis." International Journal of Rheumatic Diseases 28, no. 6 (2025). https://doi.org/10.1111/1756-185x.70303.

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ABSTRACTBackgroundNon‐radiographic axial spondyloarthritis (nr‐axSpA) is an early stage of axial spondyloarthritis characterized by the absence of definitive radiographic changes. Interleukin‐17 inhibitors (IL‐17i) have shown efficacy in treating nr‐axSpA, but a significant proportion of patients fail to respond. Identifying predictive biomarkers for IL‐17i response is crucial for optimizing treatment strategies.MethodsThis retrospective study analyzed pre‐treatment serum samples from nr‐axSpA patients treated with secukinumab. Responders (R) and non‐responders (NR) were defined based on chang

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Chen, Baoguo, Yaxin Li, Wei Li, Shuhong Ye, Lin Zhu, and Yan Ding. "Antitumor Activity and Mechanism of Terpenoids in Seaweeds Based on Literature Review and Network Pharmacology." Advanced Biology, December 22, 2023. http://dx.doi.org/10.1002/adbi.202300541.

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AbstractSeaweeds are a treasure trove of natural secondary metabolites. Terpenoids extracted from seaweeds are shown to possess a variety of antitumor cellular activities. However, due to the complex and diverse structures of terpenoids, their therapeutic targets and complex mechanisms of action have not been clarified. The present study summarises the research on terpenoids from seaweeds in oncological diseases over the last 20 years. Terpenoids show different degrees of inhibitory effects on different types of tumor cells, suggesting that terpenoids in seaweeds may have potential antitumor d

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Mellati, Azita, Letizia Lo Faro, Richard Dumbill, et al. "Kidney Normothermic Machine Perfusion Can Be Used as a Preservation Technique and a Model of Reperfusion to Deliver Novel Therapies and Assess Inflammation and Immune Activation." Frontiers in Immunology 13 (June 1, 2022). http://dx.doi.org/10.3389/fimmu.2022.850271.

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Ischaemia–reperfusion injury (IRI) is an inevitable process in transplantation and results in inflammation and immune system activation. Alpha-1 antitrypsin (AAT) has anti-inflammatory properties. Normothermic machine perfusion (NMP) can be used to deliver therapies and may help in assessing the effects of IRI and immunity. This study investigated the effects of AAT on IRI and inflammation in pig kidneys when administered during preservation, followed by normothermic reperfusion (NR) with autologous whole blood, as a surrogate for transplant. Two different models were used to deliver AAT or pl

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Whitaker, Rachel A. Hellmann. "The Biochemical Characterization of LINC00298; a Genetic Risk Factor for the Development of Alzheimer’s Disease." Alzheimer's & Dementia 19, S13 (2023). http://dx.doi.org/10.1002/alz.072160.

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AbstractBackgroundLong non‐coding RNAs (lncRNAs) are ubiquitous throughout the human system, yet many of their biological functions remain unknown. LINC00298 RNA, a long intergenic non‐coding RNA (lincRNA), is known to be a genetic risk factor for the development of Alzheimer’s disease, but until now, it had not been biochemically characterized.MethodComputational Modeling was used to develop secondary and tertiary structures of LINC00298 RNA. Liquid Chromatography (LC) and Mass Spectrometry (MS) (LC/MS) was used to identify the protein binding partners of LINC00298 RNA.ResultStructural analys

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Handa, Takumi, Hayate Sasaki, Masaki Takao, Mitsutoshi Tano, and Yasuo Uchida. "Proteomics-based investigation of cerebrovascular molecular mechanisms in cerebral amyloid angiopathy by the FFPE-LMD-PCT-SWATH method." Fluids and Barriers of the CNS 19, no. 1 (2022). http://dx.doi.org/10.1186/s12987-022-00351-x.

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Abstract Background Cerebral amyloid angiopathy (CAA) occurs in 80% of patients with Alzheimer’s disease (AD) and is mainly caused by the abnormal deposition of Aβ in the walls of cerebral blood vessels. Cerebrovascular molecular mechanisms in CAA were investigated by using comprehensive and accurate quantitative proteomics. Methods Concerning the molecular mechanisms specific to CAA, formalin-fixed paraffin-embedded (FFPE) sections were prepared from patients having AD neuropathologic change (ADNC) with severe cortical Aβ vascular deposition (ADNC +/CAA +), and from patients having ADNC witho

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Peng, Kangbo, Yingxiao Wang, Xia Lei, Yang Wang, Yanfang Yang, and Song-Tao Wu. "Inhibition of Tumor Glycolysis by Umbelliferone and Its Binding to Glycolytic Proteins." Pharmacognosy Magazine, July 10, 2023. http://dx.doi.org/10.1177/09731296231170256.

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Background and Objectives Both primary and secondary cancers require the involvement of glycolytic pathways. Cancer cell proliferation leads to the upregulation of glycolysis, which results in increased glucose consumption. For demonstrating that umbelliferone can effectively bind to several proteins involved in the glycolytic pathway, thereby inhibiting glycolysis and reducing cancer cell proliferation. Materials and Methods This study uses transcriptomics, network pharmacology, and molecular docking to predict the potential targets and possible pathways of umbelliferone against cancer and mi

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Liu, Wang, Chenchen He, Changlin Li, et al. "Natural compound Alternol actives multiple endoplasmic reticulum stress-responding pathways contributing to cell death." Frontiers in Pharmacology 15 (May 20, 2024). http://dx.doi.org/10.3389/fphar.2024.1397116.

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Background: Alternol is a small molecular compound isolated from the fermentation of a mutant fungus obtained from Taxus brevifolia bark. Our previous studies showed that Alternol treatment induced reactive oxygen species (ROS)-dependent immunogenic cell death. This study conducted a comprehensive investigation to explore the mechanisms involved in Alternol-induced immunogenic cell death.Methods: Prostate cancer PC-3, C4-2, and 22RV1 were used in this study. Alternol interaction with heat shock proteins (HSP) was determined using CETSA assay. Alternol-regulated ER stress proteins were assessed

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Chen, Yinghan, Dong Wang, Meng Song, et al. "Activity and mechanism of naringin in the treatment of post-infectious cough." BMC Pulmonary Medicine 25, no. 1 (2025). https://doi.org/10.1186/s12890-025-03788-6.

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Abstract Objective To explore activity and mechanism of naringin in the treatment of PIC (Post-Infectious Cough) by virtue of network pharmacology and animal studies. Methods The targets associated with naringin were obtained from the SwissTargetPrediction and Super-PRED databases. Disease-related targets were collected from GeneCards and OMIM (Online Mendelian Inheritance in Man). Venny was utilized to identify the overlapping targets between naringin and the disease. PPI (Protein–Protein Interaction) networks for disease-related targets were constructed using STRING and Cytoscape 3.10.1. GO

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Liu, Yi, Xin Cui, Junyu Xi, and Yanming Xie. "Clinical efficacy evaluation and potential mechanism prediction on Pudilan Xiaoyan oral liquid in treatment of mumps in children based on meta-analysis, network pharmacology, and molecular docking." Frontiers in Pharmacology 13 (September 23, 2022). http://dx.doi.org/10.3389/fphar.2022.956219.

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Background: Mumps is caused by the mumps virus and is characterized by pain and parotid gland swelling. Although its incidence has declined due to vaccines, outbreaks still occur among children. In addition, it can lead to severe complications, so it has a certain perniciousness. Pudilan Xiaoyan oral liquid (PDL), a Chinese patent medicine, commonly treats children with mumps. However, its safety, efficacy, and specific mechanisms lack relevant evaluation and analysis. Therefore, we did a meta-analysis of the randomized controlled trials combined with a network pharmacology analysis to assess

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Animesh, Sarker1 and Al Amin2. "A COMPARATIVE IN SILICO STUDY FINDS A FUNCTIONAL CO-RELATION BETWEEN HUMAN HSP7C AND PLANT PROTEIN." August 24, 2018. https://doi.org/10.5281/zenodo.1403019.

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International Journal on Bioinformatics & Biosciences (IJBB) Vol.3, No.2, June 2013 DOI: 10.5121/ijbb.2013.3201 1 A COMPARATIVE IN SILICO STUDY FINDS A FUNCTIONAL CO-RELATION BETWEEN HUMAN HSP7C AND PLANT PROTEIN. Animesh Sarker1 , and Al Amin2 1Department of Biotechnology and Genetic Engineering, Mawlana Bhashani Science and Technology University, Santosh, Tangail-1902.Bangladesh. Telephone:+088-092162407 animesh_du_geb@yahoo.com 2Department of Biotechnology and Genetic Engineering, Mawlana Bhashani Science and Technology University, Santosh, Tangail-1902.Bangladesh. Telephone:+088-092162

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