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1

Lévy, Pierre-Yves. "Les genes de candida albicans codant pour les proteines hsp 70 (heat shock proteins 70) : etude preliminaire." Aix-Marseille 2, 1989. http://www.theses.fr/1989AIX20903.

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2

Silva, Luciana Pugliese da. "Estudo da expressão dos genes de choque térmico hsp90, hsp60 e hsp10 do fungo aquático Blastocladiella emersonii." Universidade de São Paulo, 2003. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-14052018-120842/.

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A proteína de choque térmico Hsp90 é uma chaperone molecular encontrada no citosol. O cDNA incompleto desta proteína foi isolado de uma biblioteca construída a partir de mRNA de células de esporulação de B. emersonii submetidas a choque térmico. Um clone genômico contendo a seqüência completa do gene hsp90 também foi isolado, seqüenciado e caracterizado. A região codificadora do gene hsp90 é interrompida por um único íntron de 184 nucleotídeos. A seqüência de aminoácidos deduzida indicou uma proteína de 71 O resíduos, com massa molecular calculada de 80.792 Da e um pl médio de 4,85. Experiment
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3

Manwell, Laurie. "Heat Shock Response Inhibition and Gene Expression in Xenopus Laevis Cultured Cells." Thesis, University of Waterloo, 2006. http://hdl.handle.net/10012/2972.

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Various genes have evolved to protect the cell against stressor-induced damage or death including the heat shock proteins (HSPs). Stressor-induced HSP gene expression involves the activation of heat shock factor (HSF), which binds to the heat shock element (HSE) found in the promoter region of <em>hsp</em> genes. Previously, our laboratory has examined the expression and function of <em>hsp</em> genes in the South African clawed frog, <em>Xenopus laevis</em>. Amphibians are particularly susceptible to adverse environmental conditions, including high temperatures and toxicants. In contr
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4

Nonoguchi, Kosuke. "Cloning of human cDNAs for Apg-1 and Apg-2, menbers of the Hsp 110 family, and chromosomal assignment of their genes." Kyoto University, 2000. http://hdl.handle.net/2433/180836.

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5

Modisakeng, Keoagile William. "Isolation and characterization of genes encoding heat shock protein 70s (hsp 70s) from two species of the coelacanth, Latimeria chalumnae and Latimeria menadoensis." Thesis, Rhodes University, 2007. http://hdl.handle.net/10962/d1004030.

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The extant coelacanths have a close resemblance to the coelacanth fossil records dating back to 230mya. Like their predecessors, the extant coelacanths inhabit rocky caves at a depth of 100-300m below sea level. In the Comoros, the water temperature at these depths is estimated to fluctuate between 14-20°C. High-level adaptation to these environment and lack of competition are thought to have led to the morphological uniformity and slow change throughout the history of the coelacanths. Under stress conditions, proteins unfold or misfold leading to the formation of aggregates. Molecular chapero
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Ncanana, Sandile Welcome. "Biolistic-mediated transformation of Eragrostis Curvula with the HSP 12 gene." Thesis, University of Cape Town, 2003. http://hdl.handle.net/11427/6771.

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Bibliography: leaves 91-107.<br>Eragrostis curvula is a desiccation sensitive monocotyledonous plant and an economically important forage grass in southern Africa. This species has a potential to be improved for drought and salt resistance among other important agronomic traits. In this study, E. curvula was used as a model system to explore the feasibility of producing pasture grasses with increased tolerance to water deficit. To date, no reports have been published on transformation of this species. This study reports the transformation of E. curvula with Saccharomyces cerevisiae Hsp 12 gene
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7

Jayavaradhan, Rajeswari. "Optimization of Gene Editing Approaches for Human Hematopoietic Stem Cells." University of Cincinnati / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1543919940219677.

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8

ARAÚJO, Maria das Dores Silva. "Diversidade genética e associação do gene do choque térmico (HSP-70.1) ao desempenho produtivo em vacas leiteiras no semiárido." Universidade Federal Rural de Pernambuco, 2015. http://www.tede2.ufrpe.br:8080/tede2/handle/tede2/6467.

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Submitted by Mario BC (mario@bc.ufrpe.br) on 2017-02-20T15:01:00Z No. of bitstreams: 1 Maria das Dores Silva Araujo.pdf: 1103464 bytes, checksum: 33d8b7521bd95fb838807bafe1acb96d (MD5)<br>Made available in DSpace on 2017-02-20T15:01:00Z (GMT). No. of bitstreams: 1 Maria das Dores Silva Araujo.pdf: 1103464 bytes, checksum: 33d8b7521bd95fb838807bafe1acb96d (MD5) Previous issue date: 2015-02-27<br>Conselho Nacional de Pesquisa e Desenvolvimento Científico e Tecnológico - CNPq<br>Heat stress is a factor that contributes to the reduction of productivity of dairy cows around the world. The demand
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Quan, Daniel L. "Cytochrome P450 Gene Expression Modulates Anoxia Sensitivity in Caenorhabditis Elegans." Thesis, University of North Texas, 2016. https://digital.library.unt.edu/ark:/67531/metadc862757/.

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With an increasing population suffering from obesity or Diabetes Mellitus (DM), it is more pertinent than ever to understand how physiological changes impact cellular processes. Patients with DM often suffer from obesity, hyperglycemia, altered fatty acids that contribute to vascular dysfunction, and increased risk to ischemia. Caenorhabditis elegans is a model system used to study the conserved insulin signaling pathway, cellular responses in whole organisms and the impact a glucose diet has on oxygen deprivation (anoxia) responses. RNA-sequencing (RNA-Seq) was used to analyze the expression
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10

Stevanin, Tania Maria. "Bacterial flavohaemoglobins : physiological function and responses to nitrosative stress." Thesis, University of Sheffield, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.340137.

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11

BRANGER, CHRISTINE. "Protection contre la leptospiose etude de deux genes d'interet : hap 1 and ompl1." Nantes, 2001. http://www.theses.fr/2001NANT2022.

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Les leptospires sont des bacteries du genre leptospira divise en plusieurs genomospecies dont certaines sont responsables d'une zoonose : la leptospirose. Des recherches anterieures ont permis l'obtention, apres purification, d'une fraction proteique de 32 kda associee a la protection contre cette maladie. Deux mini-sequences ont ete definies. L'analyse d'homologie de ces deux mini-sequences avec une banque de donnees a revele la presence de deux proteines dans la fraction 32 kda. L'existence de ces deux genes a ete confirmee par southern blot dont le profil de restriction concorde avec l'exis
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12

Génin, Stéphane. "Regulation et fonctions probables des genes hrp de la bacterie phytopathogene pseudomonas solanacearum." Paris 11, 1993. http://www.theses.fr/1993PA112048.

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La grande region hrp identifiee chez la souche gmi1000 de p. Solanacearum code pour des fonctions essentielles permettant a la fois de provoquer la maladie sur une plante hote (la tomate) et d'induire une reaction de defense, appelee reaction hypersensible, sur une plante non-hote (le tabac). L'etablissement de la sequence nucleotidique de dix-neuf des vingt-trois kilobases d'adn constituant cette region hrp a permis de mettre en evidence vingt-deux cadres ouverts de lecture. Un gene regulateur de l'expression des genes hrp a ete caracterise. Plusieurs produits hrp presentent de l'homologie av
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Leong, Fong Tat Eugene. "Hop : an unusual homeobox gene involved in heart development." Thesis, University of Leeds, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.438484.

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14

Jacob, Tiago Rinaldi. "Expressão, regulação e funcionalidade de genes HSPs no dermatófito Trichophyton rubrum." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/17/17135/tde-15052014-105536/.

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O dermatófito Trichophyton rubrum é um fungo filamentoso, queratinofílico e antropofílico, sendo o principal agente etiológico de micoses cutâneas em humanos. Sua distribuição cosmopolita e seu acometimento grave em pacientes imunocomprometidos fazem dele um dos desafios a ser enfrentado pelos serviços de saúde pública mundial. As interações patógeno-hospedeiro envolvem diferentes processos relacionados com a degradação de queratina e com modificações metabólicas que permitem sua adesão e posterior penetração nos tecidos infectados. Essas alterações são importantes para o sucesso do processo i
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Rosa, Mariana Peil da. "Expressão diferencial do gene HPS no tegumento de sementes de soja." Universidade Federal de Pelotas, 2014. http://repositorio.ufpel.edu.br:8080/handle/prefix/3208.

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Submitted by Maria Beatriz Vieira (mbeatriz.vieira@gmail.com) on 2017-03-06T13:55:03Z No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) dissertacao_mariana_peil_da_rosa.pdf: 780579 bytes, checksum: 32fb27eef72fa6d21ed64bfe1f7c5af1 (MD5)<br>Approved for entry into archive by Aline Batista (alinehb.ufpel@gmail.com) on 2017-03-09T20:15:32Z (GMT) No. of bitstreams: 2 dissertacao_mariana_peil_da_rosa.pdf: 780579 bytes, checksum: 32fb27eef72fa6d21ed64bfe1f7c5af1 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)<br>Approved for entr
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Ringuet, Hugues. "Identification génotypique des mycobactéries à croissance rapide par séquençage partiel du gène de la protéine de choc thermique de 65 kDa." Paris 5, 1997. http://www.theses.fr/1997PA05P189.

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Martins, Helena Reginaldo. "Distribuição e conservação dos genes que codificam as proteínas VgrG e Hcp em espécies de Aeromonas." Universidade do Estado do Rio de Janeiro, 2012. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=5991.

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Aeromonas spp. são bastonetes Gram negativos amplamente distribuídos nos ambientes aquáticos, com relatos de isolamento em água de abastecimento público e alimentos. Este micro-organismo possui potencial de causar doenças intestinais e extraintestinais cuja patogenicidade está associada a sua virulência multifatorial. Diversos determinantes de virulência de Aeromonas já foram identificados, incluindo sistemas de secreção de proteínas. O sistema de secreção tipo VI (SST6) é o mais recente sistema de secreção de proteínas identificado em bactérias cuja presença em estirpes no gênero Aeromonas po
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18

Christen, Susan Ehlert. "Amplificação do gene da Chaperonina HSP10 do Trypanosoma evansi." Universidade do Estado de Santa Catarina, 2010. http://tede.udesc.br/handle/handle/846.

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Made available in DSpace on 2016-12-08T16:24:09Z (GMT). No. of bitstreams: 1 PGCA10MA080.pdf: 1326677 bytes, checksum: 58057ce0c8eb68eed4a42da002d7ab29 (MD5) Previous issue date: 2010-10-20<br>Conselho Nacional de Desenvolvimento Científico e Tecnológico<br>The trypanosomiasis is enzootic caused by several species of the genus Trypanosoma. It is a hemoflagellate widely distributed and of great veterinary importance, because infects a wide variety of mammals. Trypanosoma evansi is the causative agent of disease popularly known as surra , which has great economic importance in Africa, Asia an
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19

Gonçalves, Ana Cristina Fernandes dos Santos. "Estudo genético e funcional de genes HESP envolvidos na patogenicidade de Hemileia vastatrix (Ferrugem alaranjada do cafeeiro)." Master's thesis, ISA, 2013. http://hdl.handle.net/10400.5/6676.

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Mestrado em Engenharia Agronómica - Instituto Superior de Agronomia<br>Coffee leaf rust, caused by Hemileia vastratrix, is a disease with a major impact on the economy of coffee production. The H. vastatrix – coffee interaction follows the gene for gene theory, where a resistance (R) protein located in the host cytoplasm recognizes an avirulence (Avr) protein secreted by the fungal haustoria, triggering the hypersensitive response. The major goal of this study was the identification of H. vastatrix candidate effectors, namely Avr genes. To this end, Expressed Sequence Tags (ESTs) from 454-pyro
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20

Leyva, Navarro Jose Enrique. "Brand personification through music as brand knowledge : Learning from the perspective of consumers of hip-hop music in Sweden, on the associations of music in sneaker brands." Thesis, Högskolan i Jönköping, Internationella Handelshögskolan, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-14979.

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Background. Previous research on the investigation of brand personality (BP) can be found to use the personification metaphor of brands through celebrities, occupations and animals. Brand image research aims to discover the human characteristics attached to a brand. In this regard, the author suggests that as music can tell much of the personality of a person, then it would be possible to know the personality of a brand through music. The rationale behind is that music elicits “extramusical” information, such as emotions, values, dress codes and stereotypes of people; in relation to musical-ge
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21

Collares, Favorino José de Freitas. "Expressão gênica e taxas de desenvolvimento de embriões Mus musculus domesticus expostos à pressão gasosa no estágio de 8-células e submetidos à crioconservação no estágio de blastocisto." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2014. http://hdl.handle.net/10183/108173.

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Os objetivos dos experimentos foram primeiro determinar as taxas de desenvolvimento in vitro de embriões murinos no estágio de 8-células expostos a 15.7 MPa de N2 durante 2 ou 4 horas. Segundo, determinar as taxas de sobrevivência embrionária à crioconservação dos blastocistos originados a partir do cultivo dos embriões de 8-células após a indução do estresse subletal celular com o auxílio da pressão gasosa. Terceiro, determinar a expressão dos genes BAX, Bcl2, GLUT1, GLUT3, IGF1, IGF2, IGF1-R, IGF2-R, SOD2, HSP70.1, AQP3 e PPIA nas seguintes etapas experimentais: no estágio de 8-células imedi
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Schembri-Wismayer, Pierre. "Transcription factor binding to, and regulation of, the HNP-1 defensin gene promoter." Thesis, University of Glasgow, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.341726.

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23

HUGUET, ELISABETH. "Caracterisation moleculaire detaillee de la partie droite de la region des genes hrp de xanthomonas campestris pv. Vesicatoria." Paris, Institut national d'agronomie de Paris Grignon, 1998. http://www.theses.fr/1998INAP0028.

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La bacterie a gram-negatif phytopathogene xanthomonas campestris pv. Vesicatoria (xcv) est l'agent de la gale bacterienne sur le poivron et la tomate. Chez xcv, les genes hrp (hypersensitive reaction and pathogenicity) sont necessaires a l'etablissement de la maladie sur un hote sensible, et a l'induction de la reaction d'hypersensibilite sur un hote resistant, ou un non-hote. La plupart des genes hrp sont situes dans un region chromosomique de 23 kb, et sont organises en six groupes de complementation nommes hrpa a hrpf. Certains produits des genes hrp codent des proteines qui composent un ap
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Sutter, Nathaniel Barrett. "Suppression of stable and variegating position effects by the 5'HS2 and inducible 3MRE enhancers /." Thesis, Connect to this title online; UW restricted, 2001. http://hdl.handle.net/1773/5038.

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Jäger, Sarah Christina [Verfasser]. "Hybrid Assembly of Whole Genome Shotgun Sequences of Two Sugar Beet (Beta vulgaris L.) Translocation Lines Carrying the Beet Cyst Nematode Resistance Gene Hs1-2 and Functional Analysis of Candidate Genes / Sarah Christina Jäger." Kiel : Universitätsbibliothek Kiel, 2013. http://d-nb.info/1054661898/34.

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Merighi, Massimo. "Molecular biology and biochemistry of regulation of Hrp/type III secretion genes in the corn pathogen Pantoea stewartii pv. stewartii." Connect to this title online, 2004. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1069854564.

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Thesis (Ph. D.)--Ohio State University, 2004.<br>Document formatted into pages; contains xxxiii, 421 p. Includes bibliographical references. Abstract available online via OhioLINK's ETD Center; full text release delayed at author's request until 2005 Dec. 2.
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27

Jürgens, Ellen, and Filippa Karvik. "Rapp i käften, rapp i gesten, var är kvinnan förresten? : En semiotisk analys av maskulinitet och femininitet i dagens populära musikvideos inom svensk hiphop." Thesis, Jönköping University, HLK, Medie- och kommunikationsvetenskap, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-51842.

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Följande studie är en undersökning kring hur en del av dagens mest populära musikvideos inom den svenska hiphop-genren reproducerar normativa könsstereotyper. Under år 2019 dominerade svensk hiphop de svenska topplistorna och den både produceras och konsumeras i dagsläget av unga människor. Trots genrens popularitet har mycket kritik riktats mot den. Genren är ur vissa aspekter mansdominerad, heteronormativ och sexistisk. Det är dessutom ett känt faktum att könsnormativa stereotyper frekvent förekommer i musikvideos. Einár, Ant Wan och Z.E är ett urplock ur Sveriges mest populära rappare med m
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Piton, Valérie. "Induction combinée des gènes c-fos, hsp 70 et activation du gène gfap au cours de crises épileptiques provoquées par le soman, un neurotoxique organophosphore." Montpellier 1, 1997. http://www.theses.fr/1997MON1T012.

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Ghiaur, Gabriel. "The role of Rho GTPases in hematopoietic stem cell biology RhoA GTPase regulates adult HSC engraftment and Rac1 GTPases is important for embryonic HSC /." Cincinnati, Ohio : University of Cincinnati, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1204374567.

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30

Chang, Teh-Tsai. "Subcloning and Nucleotide Sequence of Two Positive Acting Regulatory Genes, xy1R and xy1S, from the Pseudomonas putida HS1 TOL Plasmid PDK1." Thesis, University of North Texas, 1992. https://digital.library.unt.edu/ark:/67531/metadc278595/.

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TOL plasmids of Pseudomonas putida encode enzymes for the degradation of toluene and related aromatics. These genes are organized into two operons regulated by the Xy1R and Xy1S transcriptional activators. Previous analysis of the TOL pDK1 catechol-2,3-dioxygenase gene (xy1E) and a comparison of this gene to xy1E from the related TOL plasmid pWW0, revealed the existance of a substantial level of sequence homology (82%).
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Malinkevich, Anna. "MIRAGE DNA Transposon Silencing by C. elegans Condensin II Subunit HCP-6: A Masters Thesis." eScholarship@UMMS, 2014. http://escholarship.umassmed.edu/gsbs_diss/754.

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Mobile genetic elements represent a large portion of the genome in many species. Posing a danger to the integrity of genetic information, silencing and structural machinery has evolved to suppress the mobility of foreign and transposable elements within the genome. Condensin proteins – which regulate chromosome structure to promote chromosome segregation – have been demonstrated to function in repetitive gene regulation and transposon silencing in several species. In model system Caenorhabditis elegans, microarray analysis studies have implicated Condensin II subunit HCP-6 in the silencing of
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Zhang, Jin. "Regulation of apolipoprotein A-I gene expression in Hep G2 cells depleted of copper by cupruretic tetramine." Diss., The University of Arizona, 1994. http://hdl.handle.net/10150/186914.

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Two cupruretic chelators, 2,3,2-tetramine and diamsar were used to deplete copper from Hep G2 cells. Studies using incremental concentrations of chelators, an average maximal depletion of 45% of cellular Cu amounting to 2.4 or 2.3 pmol Cu/μg DNA were attained after 24 h of incubation with 10 μM of tetramine or diamsar in basal medium containing 0.63 μM of Cu. In time-course studies, maximal depletion of Cu was rapidly reached after only 5 h of treatment with 50 μM of these chelators for cells cultured in basal medium. In long-term Cu depletion studies, cellular Cu was reduced more than 40% as
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Fraga, Michelle. "Complexação de pDNA com nanoemulsões catiônicas : estudos de formulação e toxicidade em células Hep G2." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2007. http://hdl.handle.net/10183/11097.

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Nanoemulsões catiônicas têm sido recentemente propostas como sistemas carreadores de DNA. O presente trabalho teve por objetivo avaliar a influência de diferentes fosfolipídeos sobre propriedades dos complexos formados entre nanoemulsões e pDNA (pTracerTMCMV2). Em uma primeira etapa, nanoemulsões catiônicas constituídas de triglicerídeos de cadeia média, estearilamina, lecitina de gema de ovo ou fosfolipídeos isolados (DSPC, DOPC, DSPE ou DOPE), glicerol e água foram preparadas através do procedimento de emulsificação espontânea. Independente do tipo de fosfolipídeo empregado, esse procediment
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Pan, Tianyuan [Verfasser], Edmund [Akademischer Betreuer] Maser та Sabine [Gutachter] Fuchs. "Isolation and identification of two repressors, TetR AND LuxR, FOR 3,17β-hsd and 3α-hsd/cr gene regulation in Comamonas testosteroni / Tianyuan Pan ; Gutachter: Sabine Fuchs ; Betreuer: Edmund Maser". Kiel : Universitätsbibliothek Kiel, 2019. http://d-nb.info/1202630332/34.

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Banerjea, Koushik. "Criminally hip : a critical exploration into issues of masculinity, violence and transnational modernity within the spaghetti western and gangster film genres." Thesis, London South Bank University, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.506698.

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My research explores the contingency of key discourses of masculinity, race and violence as they are filtered through particular film genres in which it is the very masculinist dimension of their cultural narratives which is emphasized. To that end the two genres which I focus upon are the 'spaghetti' western and the 'gangster' film. I explore the formative role of cultural production in the circulation and critique of masculinist, or in the case of the screen 'outlaw' or 'gangster', hypermasculinist discourses, particularly as they intersect with issues of racial or ethnic difference. This in
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Mattison, Stacey. "Analysis of the human HSP70-HSP90 organising protein (HOP) gene - characterisation of the promoter and identification of a novel isoform." Thesis, Rhodes University, 2018. http://hdl.handle.net/10962/62821.

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Santos, Mariana Fernanda. "Impacto de polimorfismos de genes do metabolismo do folato e do microRNA hsa-mir-149 no risco para cardiopatias congênitas em indivíduos com síndrome de Down." Faculdade de Medicina de São José do Rio Preto, 2016. http://hdl.handle.net/tede/398.

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Submitted by Fabíola Silva (fabiola.silva@famerp.br) on 2018-02-15T12:46:24Z No. of bitstreams: 1 marianafernandadossantos_dissert.pdf: 1735247 bytes, checksum: 1bde0ab992e930a0190504964f47726e (MD5)<br>Made available in DSpace on 2018-02-15T12:46:25Z (GMT). No. of bitstreams: 1 marianafernandadossantos_dissert.pdf: 1735247 bytes, checksum: 1bde0ab992e930a0190504964f47726e (MD5) Previous issue date: 2016-12-01<br>Fundação de Amparo à Pesquisa do Estado de São Paulo - FAPESP<br>Introduction: Congenital heart defects (CHD) are present in approximately 40 to 60% of individuals with Down syndro
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Doehl, Johannes. "Investigating the role of the Leishmania (Leishmania) major HASP and SHERP genes during metacyclogenesis in the sand fly vectors, Phlebotomus (Phlebotomus) papatasi and Ph. (Ph.) duboscqi." Thesis, University of York, 2013. http://etheses.whiterose.ac.uk/4807/.

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Leishmania parasites are the causative agents of a diverse spectrum of infectious diseases termed the leishmaniases. These digenetic parasites exist as intracellular, aflagellate amastigotes in a mammalian host and as extracellular flagellated promastigotes within phlebotomine sand fly vectors of the family Phlebotominae. Within the sand fly vector’s midgut, Leishmania has to undergo a complex differentiation process, termed metacyclogenesis, to transform from non-infective procyclic promastigotes into mammalian-infective metacyclics. Members of our research group have shown previously that pa
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Lombe, Chipampe Patricia. "Analysis, expression profiling and characterization of hsa-miR-5698 target genes as putative dynamic network biomarkers for prostate cancer: a combined in silico and molecular approach." University of the Western Cape, 2019. http://hdl.handle.net/11394/7026.

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Philosophiae Doctor - PhD<br>2018, the International Agency for Research on Cancer (IARC) estimated that prostate cancer (PCa) was the second leading cause of death in males worldwide. The number of deaths are expected to raise by 50 % in the next decade. This rise is attributed to the shortcomings of the current diagnostic, prognostic, and therapeutic biomarkers used in the management of the disease. Therefore, research into more sensitive, specific and effective biomarkers is a requirement. The use of biomarkers in PCa diagnosis and management takes advantage of the genetic alterations and a
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Cunnac, Sébastien. "Identification à l'échelle génomique des effecteurs dépendant du système de sécrétion de type III de la bactérie phytopathogène Ralstonia solanacearum." Toulouse 3, 2004. http://www.theses.fr/2004TOU30197.

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La bactérie phytopathogène Ralstonia solanacearum est l'agent causal du flétrissement bactérien des solanées. Les gènes hrp codent pour un appareil de sécrétion de protéines, dit de type III, qui permet l'injection d'effecteurs du pouvoir pathogène à l'intérieur des cellules végétales hôtes. Le gène régulateur hrpB contrôle l'expression des composants de la machinerie Hrp et des substrats qui l'empruntent. La caractérisation du mécanisme d'action de HrpB a permis de définir un motif cis-opérateur conservé, la boite hrpII, indispensable à l'activité des promoteurs du régulon. Une liste de 114 g
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Harvey, Travis Willoughby Darryn Scott. "Effects of concentric and eccentric muscle contractions on IL-6 signaling in human skeletal muscle and downstream regulation of HSP-72 gene expression Is IL-6 signaling involved in exercise-induced cytoprotection? /." Waco, Tex. : Baylor University, 2008. http://hdl.handle.net/2104/5284.

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Huerga, Encabo Hector 1989. "Analysis of transcription mechanisms that limit type I interferon responses." Doctoral thesis, Universitat Pompeu Fabra, 2018. http://hdl.handle.net/10803/666035.

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Charity, James Carl. "Novel exchangeable effector loci associated with the (Pseudomonas syringae HRP) pathogenicity island evidence for integron-like assembly from transposed gene cassettes /." College Park, Md. : University of Maryland, 2003. http://hdl.handle.net/1903/187.

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Thesis (M.S.) -- University of Maryland, College Park, 2003.<br>Thesis research directed by: Dept. of Cell Biology and Molecular Genetics. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.
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Posada, Estefan Olga Maria. "Study of the toxicity, immunological and gene expression effects of cobalt ions and wear debris derived from metal-on-metal hip implants." Thesis, University of Strathclyde, 2013. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=23100.

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Joint replacements have been used for over 30 years with considerable success as treatment for bone diseases. As a surgical alternative to metal on metal (MoM) total hip replacement, hip resurfacing was developed using Cobalt-Chromium (CoCr) alloys. However, debris particles are generated by wear at the articulating CoCr surfaces. The nanoparticles and ions produced disseminate throughout the body and interact with different cell types. In order to evaluate the effects of CoCr particles and ions released from MoM implants, U937 cells and primary human lymphocytes were exposed in vitro to artif
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Zhou, Xiaobai. "Experimental study of some parameters affecting polycyclic aromatic hydrocarbons (PAHs) dissipation in the rhizosphere of mycorrhizal plants." Thesis, Nancy 1, 2010. http://www.theses.fr/2010NAN10086/document.

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Les HAP sont parmi les substances les plus problématiques parce qu'ils ont un fort pouvoir cancérigène, mutagène et ont, par conséquent, des effets nocifs pour la santé humaine. Parmi les techniques de remédiation des sols contaminés par des HAP, la phytoremédiation a été reconnue comme une méthode prometteuse en raison de ses avantages économiques et écologiques. Toutefois, en raison de la nature récalcitrante des HAP, et de facteurs environnementaux difficile à maîtriser, cette technique est encore limitée en termes d'efficacité, en particulier lorsqu'il s'agit de HAP de poids moléculaires é
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Rubin, Joel Edward. "Locus control region activity by 5'HS3 requires a functional interaction with ß-globin gene regulatory elements, identification of effective ß/[gamma]-globin minigenes for gene therapy of the ß-chain hemoglobinopathies." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0025/MQ50431.pdf.

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Silva, Analice Andreoli. "Impacto de polimorfismos da região 3’ não traduzida do gene MTHFR e de polimorfismo do microRNA hsa-mir-149 no risco materno para a síndrome de Down." Faculdade de Medicina de São José do Rio Preto, 2017. http://hdl.handle.net/tede/395.

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Submitted by Fabíola Silva (fabiola.silva@famerp.br) on 2018-02-06T18:02:49Z No. of bitstreams: 1 analiceandreolidasilva_dissert.pdf: 2107238 bytes, checksum: 4f05811d9d83884b9b7412042055b250 (MD5)<br>Made available in DSpace on 2018-02-06T18:02:50Z (GMT). No. of bitstreams: 1 analiceandreolidasilva_dissert.pdf: 2107238 bytes, checksum: 4f05811d9d83884b9b7412042055b250 (MD5) Previous issue date: 2017-02-03<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES<br>Introduction: Down syndrome (DS) is a genetic condition characterized by the presence of three copies of chromoso
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Boehm, Christian Reiner. "Gene expression control for synthetic patterning of bacterial populations and plants." Thesis, University of Cambridge, 2017. https://www.repository.cam.ac.uk/handle/1810/267842.

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The development of shape in multicellular organisms has intrigued human minds for millenia. Empowered by modern genetic techniques, molecular biologists are now striving to not only dissect developmental processes, but to exploit their modularity for the design of custom living systems used in bioproduction, remediation, and regenerative medicine. Currently, our capacity to harness this potential is fundamentally limited by a lack of spatiotemporal control over gene expression in multicellular systems. While several synthetic genetic circuits for control of multicellular patterning have been r
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Barjhoux, Iris. "Étude de la biodisponibilité et de la toxicité de polluants chimiques à risque dans les sédiments aquatiques vis-à-vis des premiers stades de développement d’un poisson modèle, Oryzias latipes." Thesis, Bordeaux 1, 2011. http://www.theses.fr/2011BOR14442/document.

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Les sédiments agissent comme de véritable puits pour certains polluants organiques persistants et métaux représentant ainsi une source de contamination secondaire pour les milieux aquatiques. Dans ce contexte, un test embryo-larvaire utilisant le Medaka japonais (Oryzias latipes) a été développé afin d’évaluer la toxicité des polluants fixés aux particules sédimentaires. Le bioessai consiste à maintenir les embryons de Medaka en contact direct avec le sédiment durant tout leur développement embryonnaire puis à évaluer les effets létaux et sublétaux induits au niveau phénotypique et moléculaire
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Dubory, Arnaud. "Interface os-implant titane et ingénierie tissulaire A cadaveric validation of a method based on impact analysis to monitor the femoral stem insertion Bone marrow mesenchymal stem cells predict radiographic osseointegration of cementeless titanium hip cups Survival, adhesion, and expression of osteoblastic genes of human derived-bone marrow mesenchymal stromal cells on PEEK and titanium-coated PEEK lumbar interbody cages." Thesis, Paris Est, 2018. http://www.theses.fr/2018PESC0067.

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Introduction : Le titane, à la fois utilisé comme moyen de fixation d’un implant devant ses propriétés biomécaniques proches de l’os et comme moyen d’ostéointégration a pris une place prépondérante en orthopédie. L’ostéointégration d’un implant titane (IT) essentielle pour la pérennité de ce dernier, dépend de 2 phases : une phase primaire MECANIQUE correspondant à l’impaction ou tenue primaire de l’IT et une phase secondaire BIOLOGIQUE correspondant à la colonisation de l’IT par le tissu osseux.L’objectif de ce travail fut d’évaluer et d’améliorer lors de ces deux phases la stabilité et l’ost
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