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Dissertations / Theses on the topic 'Hsp31'

Author: Grafiati
Published: 6 September 2023

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1

Quigley, Paulene. "Structural studies of the chaperone Hsp31 from Escherichia coli /." Thesis, Connect to this title online; UW restricted, 2003. http://hdl.handle.net/1773/8696.

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2

Mujacic, Mirna. "Characterization of regulation and expression patterns of Escherichia coli Hsp31 protein /." Thesis, Connect to this title online; UW restricted, 2006. http://hdl.handle.net/1773/8119.

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3

Andrade, Warne Pedro de. "Análise da expressão dos genes TRAP1, HSPB1, HSPD1, HSPA1L e HSPA1A em amostras de câncer epitelial de ovário implicações no prognóstico e na resistência a quimioterapia baseada em platina /." Botucatu, 2018. http://hdl.handle.net/11449/154391.

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Orientador: Agnaldo Lopes da Silva Filho<br>Resumo: Introdução: As proteínas de choque térmico (“Heat Shock Proteins”) são produzidas em resposta ao estresse patofisiológico nas células animais e não só fazem parte de várias etapas da carcinogênese, atuando principalmente como agentes antiapoptóticos, como também estão implicadas em mecanismos de resistência à quimioterapia em vários tipos de tumores. Objetivo: O presente estudo visa comparar a expressão dos genes TRAP1, HSPB1, HSPD1, HSPA1L e HSPA1A nas amostras de CEO (no tumor primário ou na metástase) com a expressão dos mesmos em amostras
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4

Smith, Carly M. "HSPC1 inhibitors and their use in Chronic Lymphocytic Leukaemia." Thesis, University of Chester, 2015. http://hdl.handle.net/10034/617678.

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HSPC1 (Hsp90), a member of the anti-apoptotic Heat Shock Protein (HSP) family appears to play a pivotal role in the development and maintenance of several tumour cell characteristics and as a result has become a target for novel anti-cancer therapies. HSPC1 inhibitors have been tested in clinical trials on a wide variety of cancer types with moderate success. However, despite recent advantages in HSPC1 inhibitor development, the effects of these drugs are not consistent. A number of factors may play a role in determining cell sensitivity to these inhibitors. As Chronic Lymphocytic Leukaemia (C
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5

PATEL, VIJAY LAXMAN. "ARABIDOPSIS HSP21 AND MSRB1/MSRB2 IN PLANT STRESS TOLERANCE." Thesis, The University of Arizona, 2008. http://hdl.handle.net/10150/192201.

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6

Silva, Fábio Fernando Alves da. "Avaliação do papel de HSPB1 na modulação da autofagia induzida por PRL em células-beta." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-24082018-092045/.

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O diabetes mellitus tipo 1 é uma doença metabólica, caracterizada pela desregulação glicêmica, que ocorre devido a um ataque autoimune. A insulinoterapia é o tratamento clássico para o DM1. Contudo, alguns pacientes que apresentam essa doença não respondem de forma eficiente a este tratamento e apresentam episódios frequentes de hipoglicemia severa e despercebida (pacientes hiperlábeis). Essas complicações comprometem de forma significativa a qualidade de vida dessas pessoas. O transplante de ilhotas é uma importante alternativa para o tratamento de pacientes hiperlábeis com DM1. No entanto, e
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7

Bissonnette, Lyne. "Identification de déterminants moléculaires impliqués dans l'activation et le largage de hSPC1/furine." Mémoire, Université de Sherbrooke, 2003. http://savoirs.usherbrooke.ca/handle/11143/3327.

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SPC1/furine est une protéase à sérine active dépendante du Ca[indice supérieur ++] qui est membre de la famille des convertases de mammifères et dont l'homologue bactérien est la subtilisine. Elle est impliquée dans la maturation de plusieurs précurseurs protéiques tels que le prorécepteur à l'insuline, le pro-[bêta]-NGF, le pro-BMP-1 et la pro-fibrilline, les deux derniers étant des substrats de la matrice extracellulaire. Nous avons voulu identifier de nouveaux déterminants du pro-domaine de hSPC1 impliqués dans son auto-activation ainsi que d'autres déterminants moléculaires responsables et
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8

Samsel, Kara Ann. "The Role of Chloroplast-localized HSP21 in the Stress Responses of Arabidopsis Thaliana." Thesis, The University of Arizona, 2010. http://hdl.handle.net/10150/146645.

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Heat shock proteins (HSPs) are a ubiquitous family of protein chaperones, which prevent irreversible protein aggregation. HSPs help confer thermotolerance to organisms and can protect against other environmental stresses, such as oxidative stress. Expression levels of HSPs increase during exposure to these stresses. Small heat shock proteins (sHSPs) bind to denaturing protein to prevent aggregation. Since sHSPs are ATP-independent, ATP-dependent chaperones are involved in actively refolding proteins after release from sHSPs. Plants, including the model organism Arabidopsis thaliana, contain mu
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9

Almeida, Breno Fernando Martins de. "O papel da heme oxigenase-1 na leishmaniose visceral canina /." Araçatuba, 2016. http://hdl.handle.net/11449/143430.

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Orientador: Valéria Marçal Felix de Lima<br>Coorientador: Paulo César Ciarlini<br>Banca:Luiz Daniel de Barros<br>Banca:Flavia Lombardi Lopes<br>Banca:Suely Regina Mogami Bomfim<br>Banca; Rosimeri de Oliveira Vasconcelos<br>Resumo: A leishmaniose visceral canina (LVC) é uma doença crônica que causa imunossupressão nos animais doentes, principalmente por prejudicar a resposta imunológica celular, diminuindo a proliferação linfocitária e a capacidade fagocítica das células de defesa. Recentemente, a enzima heme oxigenase-1 (HO-1) vem ganhando destaque por estar envolvida na regulação da resposta
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10

Gibert, Benjamin. "La protéine de stress Hsp27 / HspB1, une cible de choix en thérapie anti-cancéreuse." Phd thesis, Université Claude Bernard - Lyon I, 2010. http://tel.archives-ouvertes.fr/tel-00733751.

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Hsp27 appartient à la famille des protéines dites de survie comme Bcl2 ou la survivine. C'est une protéine anti-apoptotique qui subit une dérégulation de son expression dans de nombreux types tumoraux. Elle est caractérisée comme étant une cible thérapeutique majeure. Au cours de ma thèse, j'ai isolé des peptides stabilisés, dit aptamères, capables d'inhiber fonctionnellement les activités anti-apoptotiques et tumorigènes d'Hsp27. Ces aptamères perturbent la biochimie structurale de Hsp27 et induisent le blocage du cycle cellulaire in vivo. Parallèlement à cette étude, j'ai caractérisé les eff
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11

Gomes, Vinícius de Morais. "Estudo da função de HSPB1 na citoproteção induzida pela prolactina em células beta pancreáticas." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-18082016-074927/.

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O transplante de ilhotas pancreáticas é uma terapia promissora para o tratamento da diabetes mellitus tipo 1 (DM1). No entanto, ilhotas transplantadas estão sujeitas à rejeição pelo sistema imune dos pacientes receptores, portanto faz-se necessário o desenvolvimento de mecanismos moleculares que protejam essas células. Estudos mostraram que o hormônio prolactina (PRL) é capaz de inibir a apoptose desencadeada por citocinas pró-inflamatórias sobre células beta pancreáticas e que este processo citoprotetor depende da presença da chaperona HSPB1. Foi observado que durante o desenvolvimento do DM1
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12

Tsekoa, Tsepo. "Investigating the role of a yeast membrane protein, HSP30 in tolerance to ethanol stress." Master's thesis, University of Cape Town, 2001. http://hdl.handle.net/11427/4342.

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Bibliography: leaves 59-64.<br>One of the contributors of the widespread interest the yeast Saccharomyces cerevisiae has received is its ability to yield and tolerate high levels of ethanol. S. cerevisiae is able to grow and remain viable in growth media containing ethanol concentrations as high as 19.8% (w/v), a level that is toxic to many other microorganisms. Since production of ethanol is a normal event in the growth cycyle of S. cerevisiae, this organisms has evolved a number of mechanisms to cope with deleterious effects of ethanol. These include induction of heat shock proteins (HSPs).
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13

Kammoun, Malek. "Invalidation du gène codant pour la Heat shock protein 27 chez la souris : un modèle pour comprendre le rôle de ce bio-marqueur de la tendreté de la viande bovine." Thesis, Clermont-Ferrand 2, 2013. http://www.theses.fr/2013CLF22382/document.

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La recherche des marqueurs biologiques de la tendreté a fait l’objet de nombreux travaux chez les animaux producteurs de viande et en particulier les bovins. A l’issue de ces études, une expression différentielle de la protéine Hsp27 entre des groupes de tendreté extrême a été mise en évidence. Cette protéine est présente à un « carrefour » biologique de l’interactome lié à la tendreté. Comprendre les mécanismes d’action de la protéine Hsp27 dans la tendreté de la viande bovine est l'un des défis de recherche dans le domaine de la production de viande. Dans cette optique, mon travail de thèse
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14

Mulligan, Tuttle Anne. "Characterization of the expression and function of Rana catesbeiana HSP30 and Xenopus laevis HSP27." Thesis, University of Waterloo, 2006. http://hdl.handle.net/10012/1214.

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Exposure of cells to environmental or chemical stressors will initiate the heat shock response, which is mediated by heat shock proteins. Heat shock proteins are molecular chaperones which are classified by size into six main families: HSP100, HSP90, HSP70, HSP60, HSP40 and the small heat shock proteins (sHsps). The sHsp family members bind to denatured proteins and maintain them in a folding competent state such that they may be refolded by other molecular chaperones. <br /><br /> The present study examined the expression and function of two amphibian sHsps, namely, <em>Rana catesbeia
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15

Heilman, Patrick L. "Interrogating the Functional Consequences of Peripheral Neuropathy Associated Mutations in Heat Shock Protein B1." The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1512028882555253.

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16

Cremers, Claudia [Verfasser], Johannes [Akademischer Betreuer] Buchner, and Ursula [Akademischer Betreuer] Jakob. "Functional and structural characterization of the redox regulated chaperone Hsp33 / Claudia Cremers. Gutachter: Ursula Jakob ; Johannes Buchner. Betreuer: Johannes Buchner." München : Universitätsbibliothek der TU München, 2012. http://d-nb.info/1038527228/34.

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17

Bruel, Nicolas. "Hsp33 controls elongation factor-tu stability and allows escherichia coli growth in the absence of the major dnak and triggerfactor chaperones." Toulouse 3, 2013. http://thesesups.ups-tlse.fr/2098/.

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Le repliement intracellulaire des protéines nouvellement synthétisées est assisté par des réseaux cellulaires de protéines chaperons. Chez Escherichia coli, la coopération entre les protéines chaperons Trigger Factor (TF) et DnaK est prédominante dans ce processus. En accord avec ceci, la délétion simultanée des gènes codants pour ces deux protéines chaperons conduit à une croissance bactérienne très réduite et à l'accumulation d'un grand nombre de protéines cytoplasmiques sous forme d'agrégats. Au cours de cette étude, nous avons utilisé ces phénotypes afin de mettre en évidence des interacti
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18

Nowakowska, Marta [Verfasser], and Heidrun [Akademischer Betreuer] Potschka. "Analysis of expression patterns of heat shock proteins HSPA1, HSPA5 and HSPH4 in the course of epileptogenesis / Marta Nowakowska ; Betreuer: Heidrun Potschka." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2020. http://d-nb.info/1221062077/34.

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19

Kepenekian, Vahan. "Métastases péritonéales : administration intrapéritonéale de chimiothérapies anticancéreuses pour lutter contre la chimiorésistance." Thesis, Lyon, 2019. http://www.theses.fr/2019LYSE1060.

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La carcinose péritonéale est une atteinte néoplasique métastatique de la séreuse péritonéale caractérisée par la diffusion de multiples nodules tumoraux. Son pronostic est sombre, marqué par une chimiorésistance. Les traitements intrapéritonéaux, développés pour délivrer des drogues de chimiothérapie anti-cancéreuse directement au contact de ces nodules, ont permis d’améliorer en partie les résultats oncologiques de cette pathologie. Le principe est de mettre à profit la barrière péritonéo-plasmatique pour administrer des posologies plus élevées de drogues, directement au contact des nodules,
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20

Regnacq, Matthieu. "Etude d'un nouveau gène heat shock dont l'expression est associée à l'entrée en phase stationnaire chez la levure saccharomyces cerevisiae : le gène HSP30." Bordeaux 2, 1992. http://www.theses.fr/1992BOR28213.

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21

Wier, Christopher G. "Motor Unit Integrity in Pathophysiological States and the Assessment of Potential Neuroprotective Therapeutics." The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1542720030801755.

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22

Domingues, Ana Sofia Jesus. "A reporter system to study the role of tRNA modifying enzymes in human proteostasis." Master's thesis, Universidade de Aveiro, 2016. http://hdl.handle.net/10773/21083.

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Mestrado em Biologia Molecular e Celular<br>A síntese proteica é um processo essencial para que todos os organismos mantenham a homeostasia celular. Os tRNAs são elementos cruciais na síntese proteica, uma vez que codificam a informação genética presente no mRNA. A linha celular HeLa, utilizada neste estudo, foi primeiramente isolada de uma mulher com cancro do colo do útero e desde então tem sido bastante usada na investigação, sendo muito importante no estudo das bases moleculares de muitas doenças. De modo a monitorizar a agregação proteica nesta linha celular, um sistema repórter
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23

Bankapalli, Kondalarao. "Understanding the Role of ThiJ/DJ-1/PfpI Family Member Proteins in Regulating Redox Homeostasis, Mitochondrial Health and Lifespan in Saccharomyces cerevisiae." Thesis, 2017. http://etd.iisc.ac.in/handle/2005/4208.

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In a healthy cell, the ROS levels are stringently regulated by the action of various enzymatic or non-enzymatic antioxidant systems. Imbalance in the ROS homeostasis generates oxidative stress resulting in damage to cellular macromolecules. Besides, pro-oxidants, glyoxals which are normally generated as an intermediate compound in the glycolytic pathway and other metabolic activity are known to cause oxidative stress in the cell. Elevated oxidative stress is one of the prominent cellular aetiologies associated with premature aging, cardiovascular and retinal disorders, atherosclerosis, and sev
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24

Cheng, Ya-Fang, and 鄭雅方. "Modulatory Effects of Multimodality Stimulation at Neiguan (PC 6) on Myocardial Hsp32 Expression in Rats." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/5w75r2.

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碩士<br>國立陽明大學<br>傳統醫藥學研究所<br>97<br>Hsp32 is a stress-inducible protein with prominent cardio-protective functions. The aim of this study was to investigate the effect of multimodality stimulations at acupoint PC 6 on myocardial Hsp32 expression in rats. Male Sprague-Dawley rat, weighing 260~320g, were divided into six groups, namely, lectroacupuncture group (EA), laser acupuncture group (LA), hydroacupuncture group (HA), local somatothermal stimulation group (LSTS), sham group (for EA, LA, LSTS) and normal group (for HA), under adequate anesthesia, multimodalities, such as EA, LA, HA and LSTS w
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25

Voyer, Janine. "Effect of heat shock factor inhibitor, KNK437, on stress-induced hsp30 gene expression in Xenopus laevis A6 cells." Thesis, 2008. http://hdl.handle.net/10012/3630.

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Prokaryotic and eukaryotic organisms respond to various stresses with the production of heat shock proteins (HSPs). HSPs are molecular chaperones that bind to unfolded proteins and inhibit their aggregation as well as maintaining their solubility until they can be refolded to their original conformation. Stress-inducible hsp gene transcription is mediated by the heat shock element (HSE), which interacts with heat shock transcription factor (HSF). In this study, we examined the effect of KNK437 (N-formyl-3,4-methylenedioxy-benzylidene-g-butyrolactam), a benzylidene lactam compound, on heat s
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26

Gebhardt, Tobias [Verfasser]. "Stressreaktion des Pankreas : hat die Hämoxygenase-1 (HSP32) eine protektive Wirkung auf die akute experimentelle Pankreatitis / vorgelegt von Tobias Gebhardt." 2007. http://d-nb.info/984578420/34.

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27

Khan, Saad. "Analysis of heat shock protein 30 gene expression and function in Xenopus laevis A6 kidney epithelial cells." Thesis, 2014. http://hdl.handle.net/10012/8398.

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Heat shock proteins (HSPs) are molecular chaperones that assist in protein synthesis, folding and degradation and prevent stress-induced protein aggregation. The present study examined the pattern of accumulation of HSP30 and HSP70 in cells recovering from heat shock as well as the effect of proteasome inhibition on cytoplasmic/nuclear and endoplasmic reticulum (ER) molecular chaperone accumulation, large multimeric HSP30 complexes, stress granule and aggresome formation in Xenopus laevis A6 kidney epithelial cells. Initial immunoblot analysis revealed the presence of elevated levels of HSP30
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28

Degenhardt, Ulrike [Verfasser]. "Immunhistochemische Charakterisierung nicht-melanozytärer Hauttumore anhand mono- und polyklonaler Antikörper der Hitze-Schock-Proteine HSP27, HSP32, HSP70, HSP72, HSP73 und Metallothionein / vorgelegt von Ulrike Degenhardt." 2003. http://d-nb.info/971601615/34.

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29

Dun, Matthew D. "The molecular basis of sperm - oocyte interactions." Thesis, 2012. http://hdl.handle.net/1959.13/927951.

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Research Doctorate - Doctor of Philosophy (PhD)<br>The remarkable cellular communication events that characterise the highly species specific interactions observed during the ontogeny of mammalian fertilization, represent some of the most intriguing in all of biology. Given the 60 years or so of research conducted to elucidate the precise mechanisms that underpin these interactions, it is surprising that they still remain largely unknown. This can be mostly attributed to the unique luminal environment in which the sperm reside following insemination and the direct effects that these fluids hav
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30

Šidlová, Adéla. "Analýza průběhu spermatogeneze u myší C57BL/6 po infikaci prvokem Toxoplasma gondii." Master's thesis, 2013. http://www.nusl.cz/ntk/nusl-322675.

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Toxoplasma gondii is an intracellular parasite that causes a persistent infection in 10- 80% of the world's population, depending on geographic location. Infection with this parasite causes changes in behavior and physiological functions of an infected host, including warm- blooded animals including humans. Recent studies also show influence of infection with T.gondii on male reproductive fitness in mice and rat and to investigate this issue further became a task of my diploma thesis. In this study, detailed histometric screening of testicular function along with levels of a pituitary luteiniz
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31

Ramos, Pedro André Dias. "Genome-wide shRNA screening identifies genes involved in fulvestrant resistance in breast cancer." Master's thesis, 2016. http://hdl.handle.net/10362/19135.

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Breast cancer accounts as the most prevalent cancer and the leading cause of cancer death worldwide among women. Estrogen is one main factor responsible for tumour growth in breast cancer patients through stimulation of estrogen receptor (ER) signalling. ER positive (ER+) breast cancer patients are eligible for anti-estrogenic drugs. Fulvestrant (Faslodex®) represents a second-line therapy for the treatment of postmenopausal women with ER+ advanced breast cancer. Unfortunately, a significant number of ER+ patients will develop resistance to second-line fulvestrant treatment. It is therefore i
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