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Journal articles on the topic 'HSPR'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Spohn, Gunther, Alberto Danielli, Davide Roncarati, Isabel Delany, Rino Rappuoli, and Vincenzo Scarlato. "Dual Control of Helicobacter pylori Heat Shock Gene Transcription by HspR and HrcA." Journal of Bacteriology 186, no. 10 (2004): 2956–65. http://dx.doi.org/10.1128/jb.186.10.2956-2965.2004.

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ABSTRACT The HspR repressor regulates transcription of the groESL, hrcA-grpE-dnaK, and cbpA-hspR-orf operons of Helicobacter pylori. Here we show that two of the HspR-regulated operons, namely, the groESL and dnaK operons, encoding the major cellular chaperone machineries are also regulated by the H. pylori homologue of the HrcA repressor. Similarly to the hspR mutation, deletion of the hrcA gene also leads to complete derepression of the P gro and P hrc promoters. The presence of both HspR and HrcA is therefore necessary for regulated transcription from these promoters. HrcA binds directly to

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2

Andersen, Marianne Thorup, Lone Brøndsted, Bruce M. Pearson, et al. "Diverse roles for HspR in Campylobacter jejuni revealed by the proteome, transcriptome and phenotypic characterization of an hspR mutant." Microbiology 151, no. 3 (2005): 905–15. http://dx.doi.org/10.1099/mic.0.27513-0.

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Campylobacter jejuni is a leading cause of bacterial gastroenteritis in the developed world. The role of a homologue of the negative transcriptional regulatory protein HspR, which in other organisms participates in the control of the heat-shock response, was investigated. Following inactivation of hspR in C. jejuni, members of the HspR regulon were identified by DNA microarray transcript profiling. In agreement with the predicted role of HspR as a negative regulator of genes involved in the heat-shock response, it was observed that the transcript amounts of 13 genes were increased in the hspR

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3

Holmes, Christopher W., Charles W. Penn, and Peter A. Lund. "The hrcA and hspR regulons of Campylobacter jejuni." Microbiology 156, no. 1 (2010): 158–66. http://dx.doi.org/10.1099/mic.0.031708-0.

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The human pathogen Campylobacter jejuni has a classic heat shock response, showing induction of chaperones and proteases plus several unidentified proteins in response to a small increase in growth temperature. The genome contains two homologues to known heat shock response regulators, HrcA and HspR. Previous work has shown that HspR controls several heat-shock genes, but the hrcA regulon has not been defined. We have constructed single and double deletions of C. jejuni hrcA and hspR and analysed gene expression using microarrays. Only a small number of genes are controlled by these two regula

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4

Palombo, Marta, Vincenzo Scarlato, and Davide Roncarati. "Cooperative Regulation of Campylobacter jejuni Heat-Shock Genes by HspR and HrcA." Microorganisms 8, no. 8 (2020): 1161. http://dx.doi.org/10.3390/microorganisms8081161.

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The heat-shock response is defined by the transient gene-expression program that leads to the rapid accumulation of heat-shock proteins. This evolutionary conserved response aims at the preservation of the intracellular environment and represents a crucial pathway during the establishment of host–pathogen interaction. In the food-borne pathogen Campylobacter jejuni two transcriptional repressors, named HspR and HrcA, are involved in the regulation of the major heat-shock genes. However, the molecular mechanism underpinning HspR and HrcA regulatory function has not been defined yet. In the pres

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5

Roncarati, Davide, Alberto Danielli, Gunther Spohn, Isabel Delany, and Vincenzo Scarlato. "Transcriptional Regulation of Stress Response and Motility Functions in Helicobacter pylori Is Mediated by HspR and HrcA." Journal of Bacteriology 189, no. 20 (2007): 7234–43. http://dx.doi.org/10.1128/jb.00626-07.

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ABSTRACT The hrcA and hspR genes of Helicobacter pylori encode two transcriptional repressor proteins that negatively regulate expression of the groES-groEL and hrcA-grpE-dnaK operons. While HspR was previously shown to bind far upstream of the promoters transcribing these operons, the binding sites of HrcA were not identified. Here, we demonstrate by footprinting analysis that HrcA binds to operator elements similar to the so-called CIRCE sequences overlapping both promoters. Binding of HspR and HrcA to their respective operators occurs in an independent manner, but the DNA binding activity o

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von Rosen, Tatjana, Monika Pepelnjak, Jan-Philipp Quast, Paola Picotti, and Eilika Weber-Ban. "ATP-independent substrate recruitment to proteasomal degradation in mycobacteria." Life Science Alliance 6, no. 10 (2023): e202301923. http://dx.doi.org/10.26508/lsa.202301923.

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Mycobacteria and other actinobacteria possess proteasomal degradation pathways in addition to the common bacterial compartmentalizing protease systems. Proteasomal degradation plays a crucial role in the survival of these bacteria in adverse environments. The mycobacterial proteasome interacts with several ring-shaped activators, including the bacterial proteasome activator (Bpa), which enables energy-independent degradation of heat shock repressor HspR. However, the mechanism of substrate selection and processing by the Bpa-proteasome complex remains unclear. In this study, we present evidenc

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Barreiro, Carlos, Diana Nakunst, Andrea T. Hüser, Héctor D. de Paz, Jörn Kalinowski, and Juan F. Martín. "Microarray studies reveal a ‘differential response’ to moderate or severe heat shock of the HrcA- and HspR-dependent systems in Corynebacterium glutamicum." Microbiology 155, no. 2 (2009): 359–72. http://dx.doi.org/10.1099/mic.0.019299-0.

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Genome-wide transcription profile analysis of the heat-shocked wild-type strain under moderate (40 °C) and severe heat stress (50 °C) revealed that a large number of genes are differentially expressed after heat shock. Of these, 358 genes were upregulated and 420 were downregulated in response to moderate heat shock (40 °C) in Corynebacterium glutamicum. Our results confirmed the HrcA/controlling inverted repeat of chaperone expression (CIRCE)-dependent and HspR/HspR-associated inverted repeat (HAIR)-dependent upregulation of chaperones following heat shock. Other genes, including clusters of

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8

Spohn, Gunther, Isabel Delany, Rino Rappuoli, and Vincenzo Scarlato. "Characterization of the HspR-Mediated Stress Response in Helicobacter pylori." Journal of Bacteriology 184, no. 11 (2002): 2925–30. http://dx.doi.org/10.1128/jb.184.11.2925-2930.2002.

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ABSTRACT The major heat shock genes of Helicobacter pylori are regulated by the HspR repressor. In the present study we characterize the transcriptional response of the three known HspR-dependent promoters P cbp , P gro , and P hrc to different environmental stresses. A temperature shift from 37 to 42°C causes a typical heat shock response at all three promoters characterized by an immediate and strong induction phase of transcription and a subsequent adaptation phase, which is specific for each promoter and whose onset is determined partially by the half-lives of the respective mRNAs. Exposur

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9

Ehira, Shigeki, Haruhiko Teramoto, Masayuki Inui, and Hideaki Yukawa. "Regulation of Corynebacterium glutamicum Heat Shock Response by the Extracytoplasmic-Function Sigma Factor SigH and Transcriptional Regulators HspR and HrcA." Journal of Bacteriology 191, no. 9 (2009): 2964–72. http://dx.doi.org/10.1128/jb.00112-09.

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ABSTRACT Heat shock response in Corynebacterium glutamicum was characterized by whole-genome expression analysis using a DNA microarray. It was indicated that heat shock response of C. glutamicum included not only upregulation of heat shock protein (HSP) genes encoding molecular chaperones and ATP-dependent proteases, but it also increased and decreased expression of more than 300 genes related to disparate physiological functions. An extracytoplasmic-function sigma factor, SigH, was upregulated by heat shock. The SigH regulon was defined by gene expression profiling using sigH-disrupted and o

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10

H., Surya Prakash Rao, Jeyalakshmi K., Bharathi 8., Pushpalatha L., and Umamaheswari V. "Domino products from the reaction of 1,3-diaryl-2-propen-1-ones (chalcones) with cyclopentanone." Journal of Indian Chemistry Society Vol. 78, October-December 2001 (2001): 787–95. https://doi.org/10.5281/zenodo.5902274.

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Department of Chemistry, Pondicherry University, Pondicherry-605 014, India <em>E-mail</em> : hspr@satyam.net.in I hspr@yahoo.com <em>Manuscript received 16 October 2001</em> The simple reaction of chalcones with cyclopentanone in the presence of barium hydroxide furnished complex domino products of the types 4 and 5 along with 1,5-diketones 3. Mechanistic considerations reveal that the bicyelic alcohol 4 was formed by sequential Michael-Michael-aldol reactions involving two moles of chalcone and one mole of cyclopentanone. Whereas, formation of spiro-bicyclic diol 5 involved sequent

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H., Surya Prakash Rao, Jeyalakshmi B. Bharathi L. Pushpalatha K., and Umamaheswari V. "Domino products from the reaction of 1,3-diaryl-2-propen-1-ones (chalcones) with cyclopentanone." Journal of Indian Chemical Society Vol. 78, Oct-Dec 2001 (2001): 787–95. https://doi.org/10.5281/zenodo.5910602.

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Department of Chemistry, Pondicherry University, Pondicherry-605 014, India E-mail: hspr@satyam.net.in /hspr@yahoo.com <em>Manuscript received 16 October 2001</em> The simple reaction of chalcones with cyclopentanone in the presence of barium hydroxide furnished complex domino products of the types 4 and 5 along with 1,5-diketones 3. Mechanistic considerations reveal that the bicyclic alcohol 4 was formed by sequential Michael-Michael-aldol reactions involving two moles of chalcone and one mole of cyclopentanone. Whereas, formation of spiro-bicyclic diol 5.involved sequential Michael-1,2-

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12

Parijat, Priyanka, and Janendra K. Batra. "Role of DnaK in HspR-HAIR interaction ofMycobacterium tuberculosis." IUBMB Life 67, no. 11 (2015): 816–27. http://dx.doi.org/10.1002/iub.1438.

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13

Ventura, Marco, John G. Kenny, Ziding Zhang, Gerald F. Fitzgerald, and Douwe van Sinderen. "The clpB gene of Bifidobacterium breve UCC 2003: transcriptional analysis and first insights into stress induction." Microbiology 151, no. 9 (2005): 2861–72. http://dx.doi.org/10.1099/mic.0.28176-0.

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The so-called clp genes, which encode components of the Clp proteolytic complex, are widespread among bacteria. The Bifidobacterium breve UCC 2003 genome contains a clpB gene with significant homology to predicted clpB genes from other members of the Actinobacteridae group. The heat- and osmotic-inducibility of the B. breve UCC 2003 clpB homologue was verified by slot-blot analysis, while Northern blot and primer extension analyses showed that the clpB gene is transcribed as a monocistronic unit with a single promoter. The role of a hspR homologue, known to control the regulation of clpB and d

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14

Pepe, Simona, Vincenzo Scarlato, and Davide Roncarati. "The Helicobacter pylori HspR-Modulator CbpA Is a Multifunctional Heat-Shock Protein." Microorganisms 8, no. 2 (2020): 251. http://dx.doi.org/10.3390/microorganisms8020251.

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The medically important human pathogen Helicobacter pylori relies on a collection of highly conserved heat-shock and chaperone proteins to preserve the integrity of cellular polypeptides and to control their homeostasis in response to external stress and changing environmental conditions. Among this set of chaperones, the CbpA protein has been shown to play a regulatory role in heat-shock gene regulation by directly interacting with the master stress-responsive repressor HspR. Apart from this regulatory role, little is known so far about CbpA functional activities. Using biochemistry and molec

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15

Das Gupta, Twishasri, Boudhayan Bandyopadhyay, and Sujoy K. Das Gupta. "Modulation of DNA-binding activity of Mycobacterium tuberculosis HspR by chaperones." Microbiology 154, no. 2 (2008): 484–90. http://dx.doi.org/10.1099/mic.0.2007/012294-0.

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16

Berger, B., D. Moine, R. Mansourian, and F. Arigoni. "HspR Mutations Are Naturally Selected in Bifidobacterium longum When Successive Heat Shock Treatments Are Applied." Journal of Bacteriology 192, no. 1 (2009): 256–63. http://dx.doi.org/10.1128/jb.01147-09.

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ABSTRACT The development of molecular tools allowed light to be shed on several widespread genetic mechanisms aiming at limiting the effect of molecular damage on bacterial survival. For some bacterial taxa, there are limited tools in the genetic toolbox, which restricts the possibilities to investigate the molecular basis of their stress response. In that case, an alternative strategy is to study genetic variants of a strain under stress conditions. The comparative study of the genetic determinants responsible for their phenotypes, e.g., an improved tolerance to stress, offers precious clues

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17

Spohn, Gunther, and Vincenzo Scarlato. "The autoregulatory HspR repressor protein governs chaperone gene transcription in Helicobacter pylori." Molecular Microbiology 34, no. 4 (1999): 663–74. http://dx.doi.org/10.1046/j.1365-2958.1999.01625.x.

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18

Liman, Narin, and Murat Kuzkale. "Heat shock proteins exhibit distinct spatiotemporal expression patterns in the domestic cat (." Reproduction, Fertility and Development 34, no. 6 (2022): 498–515. http://dx.doi.org/10.1071/rd21155.

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Heat shock proteins (HSP) are significant regulators of cell proliferation, differentiation and apoptosis. HSP participate in ovarian physiology through proliferative and apoptotic mechanisms and the modulation of sex steroid receptor functions. We investigated whether the expression and localisation patterns of HSP in the domestic cat ovary vary with the oestrous cycle stage. Immunohistochemical analysis revealed cell type-specific localisation patterns of HSPD1/HSP60, HSPA/HSP70, HSPC/HSP90 and HSPH/HSP105 in several ovarian cells of the domestic cat, including oocytes, follicular (granulosa

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19

Vats, N., A. Raudonikiene, D. Hutchison, et al. "Helicobacter pylori hspR and hrcA mutants display altered expression of hsps and variable colonization of C57/B6 and C57/B6 IL-12-i-mice." Gastroenterology 120, no. 5 (2001): A650. http://dx.doi.org/10.1016/s0016-5085(08)83230-1.

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20

VATS, N., A. RAUDONIKIENE, D. HUTCHISON, et al. "Helicobacter pylori hspR and hrcA mutants display altered expression of hsps and variable colonization of C57/B6 and C57/B6 IL-12-i-mice." Gastroenterology 120, no. 5 (2001): A650. http://dx.doi.org/10.1016/s0016-5085(01)83230-3.

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21

Roncarati, Davide, Eva Pinatel, Elisabetta Fiore, Clelia Peano, Stefany Loibman, and Vincenzo Scarlato. "Helicobacter pylori Stress-Response: Definition of the HrcA Regulon." Microorganisms 7, no. 10 (2019): 436. http://dx.doi.org/10.3390/microorganisms7100436.

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Bacteria respond to different environmental stresses by reprogramming the transcription of specific genes whose proper expression is critical for their survival. In this regard, the heat-shock response, a widespread protective mechanism, triggers a sudden increase in the cellular concentration of different proteins, including molecular chaperones and proteases, to preserve protein folding and maintain cellular homeostasis. In the medically important gastric pathogen Helicobacter pylori the regulation of the principal heat-shock genes is under the transcriptional control of two repressor protei

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22

Schmid, Amy K., Heather A. Howell, John R. Battista, Scott N. Peterson, and Mary E. Lidstrom. "HspR is a global negative regulator of heat shock gene expression in Deinococcus radiodurans." Molecular Microbiology 55, no. 5 (2005): 1579–90. http://dx.doi.org/10.1111/j.1365-2958.2005.04494.x.

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23

Roncarati, D., A. Danielli, and V. Scarlato. "CbpA Acts as a Modulator of HspR Repressor DNA Binding Activity in Helicobacter pylori." Journal of Bacteriology 193, no. 20 (2011): 5629–36. http://dx.doi.org/10.1128/jb.05295-11.

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24

Grandvalet, Cosette, Pascale Servant, and Philippe Mazodier. "Disruption of hspR , the repressor gene of the dnaK operon in Streptomyces albus G." Molecular Microbiology 23, no. 1 (1997): 77–84. http://dx.doi.org/10.1046/j.1365-2958.1997.1811563.x.

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25

Grandvalet, Cosette, Valerie de Crecy-Lagard, and Philippe Mazodier. "The ClpB ATPase of Streptomyces albus G belongs to the HspR heat shock regulon." Molecular Microbiology 31, no. 2 (1999): 521–32. http://dx.doi.org/10.1046/j.1365-2958.1999.01193.x.

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26

Vos, Michel J., Jurre Hageman, Serena Carra, and Harm H. Kampinga. "Structural and Functional Diversities between Members of the Human HSPB, HSPH, HSPA, and DNAJ Chaperone Families†." Biochemistry 47, no. 27 (2008): 7001–11. http://dx.doi.org/10.1021/bi800639z.

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27

Versace, Giovanni, Marta Palombo, Anna Menon, Vincenzo Scarlato, and Davide Roncarati. "Feeling the Heat: The Campylobacter jejuni HrcA Transcriptional Repressor Is an Intrinsic Protein Thermosensor." Biomolecules 11, no. 10 (2021): 1413. http://dx.doi.org/10.3390/biom11101413.

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The heat-shock response, a universal protective mechanism consisting of a transcriptional reprogramming of the cellular transcriptome, results in the accumulation of proteins which counteract the deleterious effects of heat-stress on cellular polypeptides. To quickly respond to thermal stress and trigger the heat-shock response, bacteria rely on different mechanisms to detect temperature variations, which can involve nearly all classes of biological molecules. In Campylobacter jejuni the response to heat-shock is transcriptionally controlled by a regulatory circuit involving two repressors, Hs

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28

Yang, Tao, Liang Zhang, Hongyan Hao, et al. "Nuclear‐localized At HSPR links abscisic acid‐dependent salt tolerance and antioxidant defense in Arabidopsis." Plant Journal 84, no. 6 (2015): 1274–94. http://dx.doi.org/10.1111/tpj.13080.

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29

Delany, Isabel, Gunther Spohn, Rino Rappuoli, and Vincenzo Scarlato. "In vitro selection of high affinity HspR-binding sites within the genome of Helicobacter pylori." Gene 283, no. 1-2 (2002): 63–69. http://dx.doi.org/10.1016/s0378-1119(01)00785-5.

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30

Hoffman, Paul S., Neeraj Vats, Donna Hutchison, et al. "Development of an Interleukin-12-Deficient Mouse Model That Is Permissive for Colonization by a Motile KE26695 Strain of Helicobacter pylori." Infection and Immunity 71, no. 5 (2003): 2534–41. http://dx.doi.org/10.1128/iai.71.5.2534-2541.2003.

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ABSTRACT The identification of genes associated with colonization and persistence of Helicobacter pylori in the gastric mucosa has been limited by the lack of robust animal models that support infection by strains whose genomes have been completely sequenced. Here we report that an interleukin-12 (IL-12)-deficient mouse (IL-12−/− p40 subunit knockout in C57BL/6 mouse) is permissive for infection by a motile variant (KE88-3887) of The Institute For Genomic Research-sequenced strain (KE26695) of H. pylori. The IL-12-deficient mouse was also more permissive for colonization by the mouse-colonizin

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31

Gusmano, Michael K., Victor G. Rodwin, and Daniel Weisz. "Hospitalisations sensibles aux soins de premier recours (HSPR) en Île-de-France : une perspective d'outre-Atlantique." Revue française des affaires sociales 1, no. 3 (2013): 108. http://dx.doi.org/10.3917/rfas.126.0108.

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Okay, Sezer, Rukiye Çetin, Fatih Karabulut, Cennet Doğan, Süheyla Sürücüoğlu, and Aslıhan Kurt Kızıldoğan. "Immune responses elicited by the recombinant Erp, HspR, LppX, MmaA4, and OmpA proteins fromMycobacterium tuberculosisin mice." Acta Microbiologica et Immunologica Hungarica 66, no. 2 (2019): 219–34. http://dx.doi.org/10.1556/030.65.2018.048.

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33

Bucca, Giselda, Anna M. E. Brassington, Hans-Joachim Schönfeld, and Colin P. Smith. "The HspR regulon of Streptomyces coelicolor: a role for the DnaK chaperone as a transcriptional co-repressor†." Molecular Microbiology 38, no. 5 (2002): 1093–103. http://dx.doi.org/10.1046/j.1365-2958.2000.02194.x.

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Bandyopadhyay, B., T. Das Gupta, D. Roy, and S. K. Das Gupta. "DnaK Dependence of the Mycobacterial Stress-Responsive Regulator HspR Is Mediated through Its Hydrophobic C-Terminal Tail." Journal of Bacteriology 194, no. 17 (2012): 4688–97. http://dx.doi.org/10.1128/jb.00415-12.

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35

Bucca, G., Z. Hindle, and C. P. Smith. "Regulation of the dnaK operon of Streptomyces coelicolor A3(2) is governed by HspR, an autoregulatory repressor protein." Journal of bacteriology 179, no. 19 (1997): 5999–6004. http://dx.doi.org/10.1128/jb.179.19.5999-6004.1997.

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Hageman, Jurre, and Harm H. Kampinga. "Computational analysis of the human HSPH/HSPA/DNAJ family and cloning of a human HSPH/HSPA/DNAJ expression library." Cell Stress and Chaperones 14, no. 1 (2008): 1–21. http://dx.doi.org/10.1007/s12192-008-0060-2.

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Murphy, Gail Tomblin, Tara Sampalli, Mark Embrett, et al. "Training it Forward: The Role of Embedded Research Fellows in the Network of Scholars Program in Nova Scotia Comment on "Early Career Outcomes of Embedded Research Fellows: An Analysis of the Health System Impact Fellowship Program"." International Journal of Health Policy and Management 13 (November 12, 2024): 8653. http://dx.doi.org/10.34172/ijhpm.8653.

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Kasaai et al describe the career trajectories of embedded scientists trained through the Health System Impact Fellowship (HSIF), showing that 37% of 2017–2019 HSIF alumni continue as embedded researchers in health systems. These findings suggest that the HSIF program effectively supports career readiness in health services and policy research (HSPR). Similarly, the Network of Scholars (NoS) program, launched post-pandemic in Nova Scotia, mirrors these results, with alumni continuing in embedded roles and mentoring a new cohort of learners from undergraduate to postgraduate levels. NoS has inco

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Zomer, Aldert, Matilde Fernandez, Breda Kearney, Gerald F. Fitzgerald, Marco Ventura, and Douwe van Sinderen. "An Interactive Regulatory Network Controls Stress Response in Bifidobacterium breve UCC2003." Journal of Bacteriology 191, no. 22 (2009): 7039–49. http://dx.doi.org/10.1128/jb.00897-09.

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ABSTRACT Members of the genus Bifidobacterium are gram-positive bacteria that commonly are found in the gastrointestinal tract (GIT) of mammals, including humans. Because of their perceived probiotic properties, they frequently are incorporated as functional ingredients in food products. From probiotic production to storage and GIT delivery, bifidobacteria encounter a plethora of stresses. To cope with these environmental challenges, they need to protect themselves through stress-induced adaptive responses. We have determined the response of B. breve UCC2003 to various stresses (heat, osmotic,

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K.Thamizhmaran. "Wireless Ad hoc Reactive Routing Protocols in Mobile Ad hoc Networks." Journal of Optoelectronics and Communication 7, no. 1 (2025): 34–45. https://doi.org/10.5281/zenodo.15152925.

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<em>Mobile Adhoc Networks (MANETs) need scalable, dependable, and efficient routing. Most significantly, each node in the MANETs can function as both a transmitter and a receiver within its communication range. Because of their high level of security, self-organization, and speed of deployment, they can access data and services from any location using dynamic routing. Among the different air communication technologies, MANETs are important because they have mobile nodes that can be randomly connected via wireless links. </em><em>Every node in the network functions as a router and keeps track o

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Bucca, Giselda, Emma Laing, Vassilis Mersinias, et al. "Development and application of versatile high density microarrays for genome-wide analysis of Streptomyces coelicolor: characterization of the HspR regulon." Genome Biology 10, no. 1 (2009): R5. http://dx.doi.org/10.1186/gb-2009-10-1-r5.

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41

Salerno, Paola, Sandra Marineo, and Anna Maria Puglia. "The Streptomyces coelicolor dnaK operon contains a second promoter driving the expression of the negative regulator hspR at physiological temperature." Archives of Microbiology 188, no. 5 (2007): 541–46. http://dx.doi.org/10.1007/s00203-007-0269-y.

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Sobczyk, André, Audrey Bellier, Julie Viala, and Philippe Mazodier. "The lon gene, encoding an ATP-dependent protease, is a novel member of the HAIR/HspR stress-response regulon in actinomycetes." Microbiology 148, no. 6 (2002): 1931–37. http://dx.doi.org/10.1099/00221287-148-6-1931.

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Jastrab, Jordan B., Tong Wang, J. Patrick Murphy, et al. "An adenosine triphosphate-independent proteasome activator contributes to the virulence ofMycobacterium tuberculosis." Proceedings of the National Academy of Sciences 112, no. 14 (2015): E1763—E1772. http://dx.doi.org/10.1073/pnas.1423319112.

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Mycobacterium tuberculosisencodes a proteasome that is highly similar to eukaryotic proteasomes and is required to cause lethal infections in animals. The only pathway known to target proteins for proteasomal degradation in bacteria is pupylation, which is functionally analogous to eukaryotic ubiquitylation. However, evidence suggests that theM. tuberculosisproteasome contributes to pupylation-independent pathways as well. To identify new proteasome cofactors that might contribute to such pathways, we isolated proteins that bound to proteasomes overproduced inM. tuberculosisand found a previou

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44

Barreiro, Carlos, Diana Nakunst, Andrea T. Hüser, Héctor D. de Paz, Jörn Kalinowski, and Juan F. Martín. "Microarray studies reveal a ‘differential response’ to moderate or severe heat shock of the HrcA- and HspR-dependent systems in Corynebacterium glutamicum." Microbiology 159, Pt_6 (2013): 1218. http://dx.doi.org/10.1099/mic.0.067926-0.

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Ren, Juanhui, Bo Ren, Qiuwen Zhang, and Xiuqing Zheng. "A Novel Hybrid Extreme Learning Machine Approach Improved by K Nearest Neighbor Method and Fireworks Algorithm for Flood Forecasting in Medium and Small Watershed of Loess Region." Water 11, no. 9 (2019): 1848. http://dx.doi.org/10.3390/w11091848.

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Sudden floods in the medium and small watershed by a sudden rainstorm and locally heavy rainfall often lead to flash floods. Therefore, it is of practical and theoretical significance to explore appropriate flood forecasting model for medium and small watersheds for flood control and disaster reduction in the loess region under the condition of underlying surface changes. This paper took the Gedong basin in the loess region of western Shanxi as the research area, analyzing the underlying surface and floods characteristics. The underlying surface change was divided into three periods (HSP1, HSP

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Flis, Łukasz, Tadeusz Malewski, and Renata Dobosz. "Temperature Effects on Expression Levels of hsp Genes in Eggs and Second-Stage Juveniles of Meloidogyne hapla Chitwood, 1949." International Journal of Molecular Sciences 25, no. 9 (2024): 4867. http://dx.doi.org/10.3390/ijms25094867.

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Meloidogyne hapla is one of the most important nematode pathogens. It is a sedentary, biotrophic parasite of plants that overwinters in the soil or in diseased roots. The development of M. hapla is temperature dependent. Numerous studies have been performed on the effect of temperature on the development of M. hapla, but only a few of them analyzed the heat shock protein (hsp) genes. The aim of the study was to perform expression profiling of eight hsp genes (Mh-hsp90, Mh-hsp1, Mh-hsp4, Mh-hsp6, Mh-hsp60, Mh-dnj19, Mh-hsp43, and Mh-hsp12.2) at two development stages of M. hapla, i.e., in eggs

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Stintzi, Alain, Denver Marlow, Kiran Palyada, et al. "Use of Genome-Wide Expression Profiling and Mutagenesis To Study the Intestinal Lifestyle of Campylobacter jejuni." Infection and Immunity 73, no. 3 (2005): 1797–810. http://dx.doi.org/10.1128/iai.73.3.1797-1810.2005.

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ABSTRACT Campylobacter jejuni is the most common bacterial cause of diarrhea worldwide. To colonize the gut and cause infection, C. jejuni must successfully compete with endogenous microbes for nutrients, resist host defenses, persist in the intestine, and ultimately infect the host. These challenges require the expression of a battery of colonization and virulence determinants. In this study, the intestinal lifestyle of C. jejuni was studied using whole-genome microarray, mutagenesis, and a rabbit ileal loop model. Genes associated with a wide range of metabolic, morphological, and pathologic

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Grandvalet, Cosette, Georges Rapoport, and Philippe Mazodier. "hrcA, Encoding the Repressor of the groELGenes in Streptomyces albus G, Is Associated with a SeconddnaJ Gene." Journal of Bacteriology 180, no. 19 (1998): 5129–34. http://dx.doi.org/10.1128/jb.180.19.5129-5134.1998.

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ABSTRACT Expression of the principal chaperones of the heat shock stimulon of Streptomyces albus G are under the negative control of different repressors. The dnaK operon is regulated byhspR, the last gene of the operon (dnaK-grpE-dnaJ-hspR). hsp18, encoding a member of the small heat shock protein family, is regulated byorfY, which is in the opposite orientation upstream ofhsp18. The groES-groEL1 operon and thegroEL2 gene are regulated differently. They present tandem copies of the CIRCE element found in the 5′ region of many heat shock genes and shown to act in Bacillus subtilis as an operat

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Vanet, Anne, and Agnès Labigne. "Evidence for Specific Secretion Rather than Autolysis in the Release of Some Helicobacter pyloriProteins." Infection and Immunity 66, no. 3 (1998): 1023–27. http://dx.doi.org/10.1128/iai.66.3.1023-1027.1998.

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ABSTRACT We investigated whether Helicobacter pylori cells actively secrete proteins such as the urease subunits UreA and UreB and the GroES and GroEL homologs HspA and HspB or whether these proteins were present in the extracellular compartment as a consequence of autolysis. Using a subcellular fractionation approach associated with quantitative Western blot analyses, we showed that the supernatant protein profiles were very different from those of the cell pellets, even for bacteria harvested in the late growth phase; this suggests that the release process is selective. A typical cytoplasmic

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Valdez-Salazar, Hilda A., Miguel A. Ares, Francisco J. Fernández, et al. "Long-chain fatty acids alter transcription of Helicobacter pylori virulence and regulatory genes." PeerJ 9 (November 1, 2021): e12270. http://dx.doi.org/10.7717/peerj.12270.

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Infection with Helicobacter pylori is one of the most important risk factors for developing gastric cancer (GC). The type IV secretion system (T4SS) encoded in the cag pathogenicity island is the main virulence factor of H. pylori associated with GC. Additionally, other virulence factors have been shown to play a role in the H. pylori virulence, such as vacuolizing cytotoxin (VacA), urease, flagella, and adhesins. Long-chain fatty acids (LCFAs) are signaling molecules that affect the transcription of virulence genes in several pathogenic bacteria such as Salmonella enterica, Vibrio cholerae, P

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