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Dissertations / Theses on the topic 'HspSO'

Author: Grafiati

Published: 10 March 2023

Last updated: 31 July 2025

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1

Foglia, Antonio. "Design, synthesis and biological evaluation of new anticancer and/or anti-inflammatory agents." Doctoral thesis, Universita degli studi di Salerno, 2017. http://hdl.handle.net/10556/2484.

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2014 - 2015<br>One of the main goal of modern medicinal chemistry is the development of new agents able to modulate biological targets involved in inflammation and cancer processes. In this context, my PhD project was focused on the exploration and structural optimization of various chemical moieties able to interfere with two targets involved in both processes. In particular, two biological targets were selected: Heat shock protein 90 (Hsp90) and microsomal Prostaglandin E2 Synthase-1 (mPGES-1). The results obtained can be divided into two sections in accordance with the target of interest.

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Bourrelle-Langlois, Maxime. "Caractérisation des petites protéines de stess/small heat shock proteins du cyanophage S-ShM2 (HspSP-ShM2) et de son hôte Synechococcus WH7803 (HspS-WH7803)." Master's thesis, Université Laval, 2016. http://hdl.handle.net/20.500.11794/26763.

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Les petites protéines de stress/Small heat shock proteins (sHsps) sont des chaperons moléculaires ATP-indépendants ubiquitaires retrouvées chez les procaryotes et eucaryotes. Elles sont dynamiques structurellement et la majorité d’entre elles possèdent la capacité de former de gros complexes oligomériques. Également, elles protègent les cellules du stress protéotoxique causé par divers facteurs de stress abiotiques en prévenant l’agrégation des protéines dénaturées et en promouvant leur repliement par les chaperons moléculaires ATP dépendants tels que Hsp70/DnaK. Récemment, la présence de gène

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Gaborit, Nadège. "Intérêt de la vectorisation et/ou de l’induction des protéines de stress dans les modèles expérimentaux de pathologies ostéoarticulaires : Validation de l’électroporation biphasique." Thesis, Nancy 1, 2008. http://www.theses.fr/2008NAN10127/document.

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Lors des pathologies articulaires, les chondrocytes sont soumis à différents processus qui concourent à la dégradation du cartilage articulaire soit en entraînant la mort par apoptose (nonrenouvellement des constituants de la matrice) soit par l’activation de protéases détruisant les constituants matriciels. Le potentiel chondroprotecteur des protéines de stress (Hsp70 / Hsp27) lors des pathologies dégénératives ayant été démontré, nous avons souhaité évaluer l'intérêt thérapeutique de l’induction de ces protéines par un inhibiteur réversible du protéasome (MG132) dans un modèle expérimental :

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Guzha, Delroy Tapiwa. "Investigating the biological roles of the HSPRO genes in Arabidopsis thaliana." Doctoral thesis, University of Cape Town, 2015. http://hdl.handle.net/11427/15503.

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As a consequence of an immobile lifestyle, plants have had to evolve appropriate perception mechanisms and responses to diverse environmental stresses. Stress can be the result of both biotic and abiotic agents and the ORTHOLOG OF SUGAR BEET HS1 PRO-1 (HSPRO 1) and HSPRO2 genes were previously shown to be induced in response to several stresses including infection with Pseudomonas syringae and drought stress in Arabidopsis thaliana. The aim of this study was to characterise the biological role(s) played by these proteins in Arabidopsis. Several bioinformatics approaches provided evidence that

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Willis, Dean. "The role of heat shock proteins in models of acute inflammation." Thesis, Queen Mary, University of London, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.265943.

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6

Fritah, Sabrina. "Implications des histones deacetylases de I et II dans la réponse au stress." Université Joseph Fourier (Grenoble), 2008. http://www.theses.fr/2008GRE10270.

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En réponse à des stress environnementaux, la cellule met en place une réponse rapide et transitoire visant à assurer sa survie. Cette réponse se traduit par l'activation du facteur HSF1(Heat shock factor 1) qui induit l'expression des gènes codant pour des protéines de choc thermique (ou HSP). L'activation des gènes hsp s'accompagne de la répression de la plupart des autres gènes cellulaires. Si l'on connait assez bien aujourd'hui les mécanismes associés à l'activation des gènes de choc thermique, peu de données existent concernant les mécanismes mis en jeu dans l'inactivation globale. Nous av

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7

Jacob, Tiago Rinaldi. "Expressão, regulação e funcionalidade de genes HSPs no dermatófito Trichophyton rubrum." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/17/17135/tde-15052014-105536/.

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O dermatófito Trichophyton rubrum é um fungo filamentoso, queratinofílico e antropofílico, sendo o principal agente etiológico de micoses cutâneas em humanos. Sua distribuição cosmopolita e seu acometimento grave em pacientes imunocomprometidos fazem dele um dos desafios a ser enfrentado pelos serviços de saúde pública mundial. As interações patógeno-hospedeiro envolvem diferentes processos relacionados com a degradação de queratina e com modificações metabólicas que permitem sua adesão e posterior penetração nos tecidos infectados. Essas alterações são importantes para o sucesso do processo i

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Monteiro, Janaína Munuera. "Imunolocalização das Heat Shock Proteins (HSPs) 60 e 70 na placenta bovina." Universidade de São Paulo, 2005. http://www.teses.usp.br/teses/disponiveis/10/10132/tde-27062006-105146/.

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As Heat Shock Proteins (HSPs) ou proteínas do choque térmico são encontradas em todas as células e são classificadas de acordo com seu peso molecular. Dentre elas encontram-se as de 27, 60, 70, 90 e 110 kDa, sendo as mais estudadas no contexto da reprodução as da família 60 e 70. Essas proteínas são ditas como chaperoninas, em razão do seu importante papel no dobramento e desdobramento de outras proteínas celulares sem alterar sua conformação final, e são expressas frente a qualquer tipo de estresse como calor, vírus, bactéria, hormônios, diferenciação celular, etc, e influenciam nas respostas

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Champagne, Marie-Josée. "Caractérisation de la relation possible entre les protéines de stress (HSPs) et l'hypertension." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape10/PQDD_0002/NQ39728.pdf.

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Coelho, Danielle Letícia Martins. "Estresse hídrico com diferentes osmóticos em sementes de feijão e expressão diferencial de proteínas durante a germinação." Universidade do Oeste Paulista, 2008. http://bdtd.unoeste.br:8080/tede/handle/tede/349.

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Made available in DSpace on 2016-01-26T18:56:17Z (GMT). No. of bitstreams: 1 dissertacao Danielle.pdf: 217929 bytes, checksum: 214e01390ff5f39b31c3b618d4cd1624 (MD5) Previous issue date: 2008-08-21<br>Snap Beans (Phaseolus vulgaris L) are highly valuable nutritionally, and it is cultivated by small, medium and big farmers. It represents a significant parcel of Brazilian economy concerning to the society. Culture emergency is a critical point in the production process and it is affected mainly by the water deficiency at this phase. The objective of this work was to simulate water deficiency i

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Velander, Ida. "Personlighetsdrag som prediktorer för högkänslighet : En enkätundersökning avseende högkänslighet i relation till personlighetsdragen enligt femfaktormodellen." Thesis, Karlstads universitet, Institutionen för sociala och psykologiska studier, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-55216.

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The aim of the present study was to investigate how sensory processing sensitivity is related to the personality traits extraversion, agreeableness, emotional stability, conscientiousness and autonomy of the five-factor model. The samples for the study were members of the Association for the Highly Sensitive in Sweden and a Facebook community for highly sensitive individuals. The participants in the present study responded on a web-based questionnaire to participate. To answer the purpose of the study The Highly Sensitive Person scale (HSPS) were used to measure the degree of a person’s sensit

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De, Simone Andrea Stefano. "Daily modulation of the Heat shock proteins (Hsps) in three different species of scleractinian corals." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2015. http://amslaurea.unibo.it/8401/.

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Temperature and light intensity is the most important environmental parameters that influence circadian cycle of scleractinian corals. In this context, modulation of the biomarkers Hsp60 and Hsp70 in situ was investigated by three different healthy coral species (Acropora tenuis, Echinopora lamellosa and Porites lobata) not stress induced during time course of 24h. Significance species-specific modulation under natural conditions is displayed by all corals under study. A strong fluctuation in Hsps expression is shown by the most susceptible, branched coral A. tenuis, instead of fine and low mo

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Christen, Susan Ehlert. "Amplificação do gene da Chaperonina HSP10 do Trypanosoma evansi." Universidade do Estado de Santa Catarina, 2010. http://tede.udesc.br/handle/handle/846.

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Made available in DSpace on 2016-12-08T16:24:09Z (GMT). No. of bitstreams: 1 PGCA10MA080.pdf: 1326677 bytes, checksum: 58057ce0c8eb68eed4a42da002d7ab29 (MD5) Previous issue date: 2010-10-20<br>Conselho Nacional de Desenvolvimento Científico e Tecnológico<br>The trypanosomiasis is enzootic caused by several species of the genus Trypanosoma. It is a hemoflagellate widely distributed and of great veterinary importance, because infects a wide variety of mammals. Trypanosoma evansi is the causative agent of disease popularly known as surra , which has great economic importance in Africa, Asia an

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Vanmuylder, Nathalie. "Contribution à l'étude de l'expression des protéines de stress (HSPs) dans les tumeurs des glandes salivaires." Doctoral thesis, Universite Libre de Bruxelles, 1999. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/211966.

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Khazzaka, Aline. "Les protéines de choc thermique-70 kDa (HSPs 70) chez le porc suite à un stress." Lyon 1, 2006. http://www.theses.fr/2006LYO10186.

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Les protéines de choc thermique (hsps) sont des familles de protéines parfaitememnt conservées à travers l'évolution des sxpèces, induites par un choc thermique ou bien par d'autres stresseurs environnementaux. Ce sont des chaperons moléculaires, elles protègent les cellules du stress et facilitent le reploiement et la maturation des protéines cellulaires. Le présent travail consite à étudier la réponse au stress des hsps 70 chez le porc de génotypes NN, Nn et nn au locus halothane (HAL) au niveau sanguin, musculaire et cellulaire. In vitro, le génotype HAL affecte la réponse hsps 70 à tous le

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Braga, Ana Cláudia Silva [UNESP]. "Inibição do vírus da hepatite C utilizando siRNAs direcionados para o genoma viral e proteínas celulares Hsps." Universidade Estadual Paulista (UNESP), 2013. http://hdl.handle.net/11449/108916.

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Made available in DSpace on 2014-08-27T14:36:46Z (GMT). No. of bitstreams: 0 Previous issue date: 2013-08-23Bitstream added on 2014-08-27T15:57:19Z : No. of bitstreams: 1 000723028_20150823.pdf: 1028906 bytes, checksum: 197bceaec267086e9658eb5a35574fe1 (MD5) Bitstreams deleted on 2015-08-24T10:46:34Z: 000723028_20150823.pdf,. Added 1 bitstream(s) on 2015-08-24T10:47:09Z : No. of bitstreams: 1 000723028.pdf: 1485800 bytes, checksum: aaac9adf54c11e7df2321502f879e475 (MD5)<br>A hepatite C é consequência da infecção pelo vírus da hepatite C (HCV) e estima-se que cerca de 150 milhões de pessoas

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Braga, Ana Cláudia Silva. "Inibição do vírus da hepatite C utilizando siRNAs direcionados para o genoma viral e proteínas celulares Hsps /." São José do Rio Preto, 2013. http://hdl.handle.net/11449/108916.

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Orientador: Paula Rahal<br>Coorientador: Bruno Moreira Carneiro<br>Banca: Maurício Lacerda Nogueira<br>Banca: Isabel Maria Vicente Guedes de Carvalho Mello<br>Resumo: A hepatite C é consequência da infecção pelo vírus da hepatite C (HCV) e estima-se que cerca de 150 milhões de pessoas em todo o mundo estejam cronicamente infectadas. Estudos têm demonstrado interações entre proteínas virais e do hospedeiro durante o ciclo de replicação do HCV e estas interações podem ser utilizadas para o desenvolvimento de novas terapias contra a hepatite C. As proteínas de choque térmico (Hsp) são proteínas c

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Ooi, Cheong Hwa. "Heat shock response and exercise-induced muscle damage: effects of 17-AAG and glutamine as pharmaceutical inducers of HSPs." Thesis, The University of Sydney, 2014. http://hdl.handle.net/2123/12615.

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This thesis comprises four interlinked studies investigating the effects of 17-AAG and glutamine (GLN) on the heat shock response, and the mechanisms underlying its cross-protective effect in limiting muscle damage and functional impairment following eccentric exercise. Study 1 aimed to replicate a previous mouse study using 17-AAG but with a different species, muscle group and exercise protocol. It was showed that downhill running increased the post-exercise red vastus HSP72 response of both 17-AAG and vehicle-treated rats but the rise in HSP72 content was attenuated by 17-AAG at 24 h after e

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Evrard, Laurence. "Contribution à l'étude de l'apoptose et des protéines de stress (HSPs) au cours du développement crânio-facial normal et tératologique." Doctoral thesis, Universite Libre de Bruxelles, 2002. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/211467.

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Lanneau, David. "Rôle des protéines de choc thermique HSP90 et HSP70 dans la différenciation macrophagique." Phd thesis, Université de Bourgogne, 2010. http://tel.archives-ouvertes.fr/tel-00560535.

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La synthèse des protéines de choc thermique (HSPs) est un moyen de défense développé par la cellule pour faire face aux diverses agressions auxquelles elle peut être soumise. En tant que chaperons, les HSPs participent aux mouvements intracellulaires des protéines, préviennent l'agrégation des protéines altérées, éliminent les protéines anormales et contribuent à la conformation correcte des peptides nouvellement synthétisées. Mon équipe d'accueil s'intéresse aux rôles des HSPs dans des processus cellulaires tels que l'apoptose et la différenciation cellulaire. Le but de mon travail de thèse c

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Conte, Talita Cristiane. "Influência das HSPs (heat shock proteins) e do mTORC-1 (mammalian target of rapamycin complex 1) na regeneração de músculos esqueléticos." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/42/42131/tde-26012010-111321/.

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O objetivo deste trabalho foi contribuir para o melhor entendimento dos mecanismos intracelulares envolvidos na regeneração muscular esquelética, através do estudo da influência das proteínas de choque térmico (HSPs) e do mTORC1 (mammalian target of rapamycin complex 1) no processo regenerativo muscular. O tratamento com radicicol (indutor de HSPs) em músculos lesados induziu aumento da área de secção transversal das fibras musculares em 10 e 21 dias após lesão e aumento do número de células satélites e de fibras musculares em diferenciação em 1 e 10 dias após lesão, respectivamente, quando co

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Mutsvunguma, Lorraine Zvichapera. "Investigating the role of heat shock proteins (Hsps) 40, 70 and 90 in the life cycle of Theiler's murine encephalomyelitis virus (TMEV)." Thesis, Rhodes University, 2011. http://hdl.handle.net/10962/d1004025.

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Introduction: Picornaviruses are a family of RNA viruses which are economically and clinically significant. Like many other viruses, picornaviruses utilise host cell machinery to facilitate their replication and assembly, including heat shock proteins (Hsps). The aim of this research was to investigate the role of Hsp40, Hsp70 and Hsp90 during picornavirus infection using the cardiovirus, Theiler’s murine encephalomyelitis virus (TMEV), as a study model. Methodology: Picornavirus VP1 capsid proteins were analysed by multiple sequence alignment and multiple structural comparisons. Protein domai

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REGGENTE, MELISSA AMANDA LJUBICA V. "Assessing the expression of different biochemical indicators in scleractinian corals subjected to biotic and abiotic stresses." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2016. http://hdl.handle.net/10281/101829.

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In the last few decades about the 27% of coral reefs have been destroyed worldwide caused by different environmental stressors, both abiotic and biotic. Moreover one of the main causes of coral reef destruction has been the dramatic increase in coral disease. In reef building corals, as well as in other organisms, several components of the cellular stress response can be used as diagnostic indicators of stress, in order to assess their cellular physiological condition, expressing them with significant different patterns in relation to different stressors. In this study the diagnostic indicato

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Moretti, Ana Iochabel Soares. "Efeito da solução hipertônica sobre a expressão de proteínas ativadas por choque térmico (HSPs) e atividade de metaloproteinases (MMPs) teciduais na resposta inflamatória em pancreatite aguda experimental." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/5/5159/tde-22102007-093706/.

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A lesão pulmonar é determinante da morbi-mortalidade na pancreatite aguda (PA). Neutrófilos (PMN) e mediadores inflamatórios são responsáveis pelo desenvolvimento da lesão. A solução hipertônica modula a reposta inflamatória tendo como resultante um efeito imunomodulatório capaz de prevenir a lesão tecidual. Neste trabalho, investigamos os efeitos da solução hipertônica sobre os níveis de HSPs, MMPs e citocinas no tecido pulmonar, bem como, o mecanismo envolvido em sua regulação. Ratos machos Wistar foram submetidos a pancreatite pela injeção retrógrada de 1 ml/Kg de taurocolato de sódio 2,5%.

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Skandrani, Dalila. "Détermination des seuils de toxicité de divers insecticides (forme pure ou commerciale) sur cellules humaines en culture (A549, SH-SY5Y) : expression des gènes et protéines de stress (HSPs, GRPs,…)." Toulouse 3, 2006. http://www.theses.fr/2006TOU30233.

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Ce travail a eu pour but de déterminer les concentrations cytotoxiques de divers insecticides (molécule pure versus formulation commerciale) qui induisaient une inhibition de la prolifération de cellules d'origine pulmonaire (A549) ou neuronale (SH-SY5Y) et d'analyser les variations d'expression de gènes de stress par la technique des cDNA arrays et/ou des protéines (HSP, GRP) sur western blot. Il a été montré que les formulations pouvaient être jusqu'à 150 fois plus toxiques que les molécules pures. Dans les cellules A549, les insecticides ont induit une surexpression de la GRP78 et une sous-

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Wildemann, Bruna. "Análise do desenvolvimento e estudo do polimorfismo de inversão cromossômica de Drosophila polymorpha (Diptera, Drosophilidae) e sua relação com genes de choque térmico (HSPs) induzidos por estresse físico/químico." reponame:Repositório Institucional da UFSC, 2014. https://repositorio.ufsc.br/xmlui/handle/123456789/129684.

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Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Biologia Celular e do Desenvolvimento, Florianópolis, 2014<br>Made available in DSpace on 2015-02-05T21:22:51Z (GMT). No. of bitstreams: 1 330280.pdf: 2597067 bytes, checksum: 9f9337ed7a914078fa1735f7ec654096 (MD5) Previous issue date: 2014<br>O objetivo geral deste trabalho foi estudar o ciclo de vida, o polimorfismo de inversão cromossômica e a possível relação dos arranjos com genes de estresse (hsps). O material de estudo foi coletado em três diferentes unidades de

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Gowda, Naveen Kumar Chandappa. "Regulation of Hsp70 function by nucleotide-exchange factors." Doctoral thesis, Stockholms universitet, Institutionen för molekylär biovetenskap, Wenner-Grens institut, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-129118.

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Protein folding is the process in which polypeptides in their non-native states attain the unique folds of their native states. Adverse environmental conditions and genetic predisposition challenge the folding process and accelerate the production of proteotoxic misfolded proteins. Misfolded proteins are selectively recognized and removed from the cell by processes of protein quality control (PQC). In PQC molecular chaperones of the Heat shock protein 70 kDa (Hsp70) family play important roles by recognizing and facilitating the removal of misfolded proteins. Hsp70 function is dependent on cof

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Decio, Pâmela. "Estresse celular e atividade de enzimas biomarcadoras em abelhas africanizadas Apis mellifera LINEU, 1758 (Hymenoptera, Apidae) expostas ao tiametoxam /." Rio Claro, 2019. http://hdl.handle.net/11449/182346.

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Orientador: Osmar Malaspina<br>Resumo: As abelhas Apis mellifera africanizadas são consideradas importantes polinizadores no Brasil, uma vez que muitas culturas de alimentos dependem da polinização promovida por esses insetos. No entanto, com o crescimento da produtividade agrícola houve aumento do uso de agrotóxicos para o controle de pragas, os quais podem atingir também insetos não-alvo. Com a ação dos inseticidas como uma das possíveis causadoras da morte massiva desses polinizadores, pesquisas sobre o impacto dos agrotóxicos em abelhas receberam destaque. Diante do exposto, o presente est

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Malheiros, Jessica Moraes. "Caracterização, quantificação e expressão de proteínas estruturais e regulatórias do tecido muscular esquelético e suas relações com as características de qualidade da carne de bovinos Nelore (Bos indicus)." Universidade Estadual Paulista (UNESP), 2018. http://hdl.handle.net/11449/153865.

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Submitted by Jéssica Moraes Malheiros (jessicamalheiros@yahoo.com.br) on 2018-05-03T18:53:41Z No. of bitstreams: 1 TESE MALHEIROS, J. M..pdf: 1363679 bytes, checksum: 33291bc89815d196826e037eeda5b237 (MD5)<br>Approved for entry into archive by Alexandra Maria Donadon Lusser Segali null (alexmar@fcav.unesp.br) on 2018-05-04T18:11:25Z (GMT) No. of bitstreams: 1 malheiros_jm_dr_jabo.pdf: 1400936 bytes, checksum: bf9a223495b522a13300edf9c4026a2e (MD5)<br>Made available in DSpace on 2018-05-04T18:11:25Z (GMT). No. of bitstreams: 1 malheiros_jm_dr_jabo.pdf: 1400936 bytes, checksum: bf9a223495b52

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XIE, MING-XUN, and 謝明勳. "I.Preparation and characterization of soybean LMW HSPs specific antibody II.Quantitative estimation of soybean LMW HSPs by polyclonal antibody." Thesis, 1990. http://ndltd.ncl.edu.tw/handle/92638856037223228222.

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"Imunolocalização das Heat Shock Proteins (HSPs) 60 e 70 na placenta bovina." Tese, Biblioteca Digital de Teses e Dissertações da USP, 2005. http://www.teses.usp.br/teses/disponiveis/10/10132/tde-27062006-105146/.

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Houlihan, Josetta Lynn. "THE ROLE OF HSPs IN MHC CLASS II PRESENTATION OF SELECT ANTIGENS." Thesis, 2009. http://hdl.handle.net/1805/2046.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>The function of major histocompatability complex (MHC) class II molecules is to present antigenic peptides to CD4+ T cells. Typically, MHC class II molecules present peptides derived from exogenous sources. Yet, certain endogenous antigens (Ags) have been found to be presented by class II molecules. Studies suggest that specific heat shock protein family members may play a role in Ag processing and subsequent class II presentation. The studies presented here using B lymphoblasts demonstrate the importance of HSP90α, HSP90β, and possi

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Wang, Pin-Rong, and 王品蓉. "The Effects of HSPs Overexpression and Oxidative Stress in SCA17 Cell Model." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/2c6pht.

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碩士<br>國立臺灣師範大學<br>生命科學研究所<br>97<br>Autosomal dominant spinocerebellar ataxias (SCAs) are a heterogeneous group of neurodegenerative disorders involving progressive degeneration of the cerebellum, brainstem, and spinal tract. More than 28 subtypes have been reported. SCA17 is caused by an expanded polyglutamine (polyQ) in a general transcription initiation factor, the TATA-box binding protein (TBP). The mutated TBP with polyQ expansion causes a conformational change to promote misfolding and aggregation. Futhermore, a polyQ mutation can induce reactive oxygen species (ROS) that directly contrib

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SHARMA, RENU. "CYCLINS, HSPs AND E3 LIGASE ACTIVITY IN CELL CYCLE DEREGULATION IN NEURO-MUSCULAR DEGENERATION." Thesis, 2017. http://dspace.dtu.ac.in:8080/jspui/handle/repository/16273.

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Parkinson’s disease (PD) is the most common neurodegenerative disorder after Alzheimer’s disease with approximately 7 million patients worldwide which are predicted to get doubled by 2030. The most common form of PD is the sporadic form with no known cause. Amongst many factors responsible for the pathogenesis of sporadic PD, Cell cycle reentry (CCE) with subsequent DNA synthesis in at-risk dopaminergic neurons has been recently identified as the cause of neuronal cell death. Neurons are post-mitotic cells which never divide, but in lieu of their physiological demands certain cel

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WANG, CHUN-YING, and 王純鶯. "The Synthesis of HSPs During Septic Shock and the Effects of Hyperthermic Treatment on Their Induction." Thesis, 1996. http://ndltd.ncl.edu.tw/handle/51952879029492773990.

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Giusi, Giusi, Bruno Tota, and Rosa Maria Facciolo. "Ruolo neuroprotettivo del sistema istaminergico e delle HSPs nella risposta allo stress ambientale nell’encefalo del Teleosteo Thalassoma pavo." Thesis, 2014. http://hdl.handle.net/10955/467.

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Dottorato di Ricerca in Biologia Animale, XIX Ciclo<br>At date, a plethora of evidence regarding adverse morpho-functional and neurobiological aspects provoked by environmental stressors has been considered. Following exposure to stress factors, the activation of both specific neurosignaling mechanisms and molecular pathways account for the modulation of complex adaptative processes in animal targets. In this context, the aim of the present work is to analyze the neuroprotective role of histaminergic system and heat shock proteins towards environmental neurotoxicants such as heavy metals

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Wang, Ting-Ting, and 王婷婷. "Reorganization of Cytoskeletal Systems as well as Redistribution of Organelles and 70 kDa HSPs in Heat-Shocked 9L RBT Cells." Thesis, 1996. http://ndltd.ncl.edu.tw/handle/97306396712407390964.

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Κοτσιλίτη, Ελένη. "Μελέτη της έκφρασης και ρύθμισης του θερμοεπαγόμενου γονιδίου hsp27 στη μεσογειακή μύγα, Ceratitis capitata". Thesis, 2012. http://hdl.handle.net/10889/5915.

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Η απόκριση των κυττάρων στο στρες συνδέεται με την επαγωγή μιας ομάδας πρωτεϊνών που ονομάζονται θερμοεπαγόμενες πρωτεΐνες (Hsps). Οι πρωτεΐνες αυτές ανήκουν στην κατηγορία των κυτταρικών συνοδών μορίων (chaperons) και προστατεύουν τα κύτταρα από τη μετουσίωση και συσσωμάτωση των πρωτεϊνών τους. Οι περισσότερες Hsps συντίθενται και σε φυσιολογικές συνθήκες και παίζουν σημαντικούς ρόλους στην ορθή αναδίπλωση, μεταφορά και αποικοδόμηση των πρωτεϊνών του κυττάρου. Οι Hsps κατηγοριοποιούνται σε διακριτές οικογένειες σύμφωνα με τα μοριακά τους βάρη. Από τις οικογένειες αυτές η οικογένεια των μικρών

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Banumathy, G. "Functional Insights Into Heat Shock Protein 90 Multi-Chaperone Complex In Plasmodium Falciparum." Thesis, 2004. https://etd.iisc.ac.in/handle/2005/1150.

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Banumathy, G. "Functional Insights Into Heat Shock Protein 90 Multi-Chaperone Complex In Plasmodium Falciparum." Thesis, 2004. http://etd.iisc.ernet.in/handle/2005/1150.

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Rishi, Kumar N. "Insights Into The Trans-Splicing Based Expression Of Heat Shock Protein 90 In Giardia Lamblia." Thesis, 2012. http://etd.iisc.ac.in/handle/2005/2566.

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Heat shock proteins (Hsps) are a class of molecular chaperones which were first discovered as proteins up-regulated in response to heat stress in Drosophila. Later, it was found that these set of proteins get up-regulated as a general stress response associated with destabilization of native protein structures. Over a period of time, intricate involvement of Hsps in various biological processes has been well established. Heat shock protein 90 (Hsp90) is one of the important representative of this class of proteins. Hsp90 is an essential molecular chaperone which is evolutionarily conserved. I

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Rishi, Kumar N. "Insights Into The Trans-Splicing Based Expression Of Heat Shock Protein 90 In Giardia Lamblia." Thesis, 2012. http://etd.iisc.ernet.in/handle/2005/2566.

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Heat shock proteins (Hsps) are a class of molecular chaperones which were first discovered as proteins up-regulated in response to heat stress in Drosophila. Later, it was found that these set of proteins get up-regulated as a general stress response associated with destabilization of native protein structures. Over a period of time, intricate involvement of Hsps in various biological processes has been well established. Heat shock protein 90 (Hsp90) is one of the important representative of this class of proteins. Hsp90 is an essential molecular chaperone which is evolutionarily conserved. I

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Oliveira, Diana Filipa Moreira de. "Heat shock proteins in translational oncology." Master's thesis, 2020. http://hdl.handle.net/10400.26/33354.

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Proteínas de Choque Térmico são um grupo de proteínas que é induzido em resposta ao stress e situações lesivas. As várias proteínas que pertencem a este grupo estão divididas em famílias, de acordo com o seu peso molecular. Podem ser distinguidas a HSP72, HSP40, HSP60, HSP70, HSP90 e uma família adicional de grandes HSPs. Este é um grupo de proteínas que é constitutivamente expresso em células normais sendo responsável pela homeostase celular. É de facto o seu nível de expressão basal que sustenta os processos que ocorrem num ambiente intracelular saudável. Uma vez que as HSPs interagem com m

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