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Journal articles on the topic 'HT-22 cell line'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Qi, Huizhen, та Liang Liu. "Rhoifolin attenuates damage to hippocampal neuronal culture model of acquired epilepsy in vitro by regulating NF-κB/iNOS/COX-2 axis". Quality Assurance and Safety of Crops & Foods 14, № 3 (2022): 116–23. http://dx.doi.org/10.15586/qas.v14i3.1093.

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To assess the effect of Rhoifolin (ROF [apigenin 7-O-enneohesperidoside]) on the damage to hippocampal neu-ronal culture model of acquired epilepsy (AE) and investigate its possible mechanisms. A hippocampal neuronal culture model of AE was established through incubating HT-22 cells with MgCl2 free medium. 3-(4,5-Dimethylth-iazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assays were used to assess the effect of ROF on cell viability and apoptosis exposed to epilepsy. The oxidative stress and secretion of inflammatory cy

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Kim, Si-Yeon, Jung-Ho Lee, and Soon-Ae Kim. "Zinc Deficiency Induces Autophagy in HT-22 Mouse Hippocampal Neuronal Cell Line." International Journal of Molecular Sciences 23, no. 15 (2022): 8811. http://dx.doi.org/10.3390/ijms23158811.

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Zinc is a trace metal vital for various functions in nerve cells, although the effect of zinc deficiency on neuronal autophagy remains unclear. This study aimed to elucidate whether zinc deficiency induced by treatment with N, N, N′, N′-tetrakis (2-pyridylmethyl) ethylenediamine (TPEN), a zinc chelator, affects and alters autophagy activity. In cell viability assays, TPEN showed cytotoxicity in HT-22 cells. TPEN treatment also increased LC3-II levels and the ratio of LC3-II to LC3-I. Western blot analysis showed that phospho-AMP-activated protein kinase levels and the ratio of phospho-AMP-acti

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V., Karri, Kumar V., Ramos D., Oliveira E., and Schuhmacher M. "An in vitro cytotoxic approach to assess the toxicity of heavy metals and their binary mixtures on hippocampal HT-22 cell line." Toxicology letters 282 (October 5, 2017): 25–36. https://doi.org/10.1016/j.toxlet.2017.10.002.

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Humans are exposed to a cocktail of heavy metal toxicants in the environment. Though heavy metals are deleterious, there is a paucity of information on the toxicity of mixtures. In this study, four common neurotoxicity heavy metals lead (Pb) cadmium (Cd), arsenic (As), and methylmercury (MeHg) were exposed individually and as mixtures to HT-22 cell line for 8days. The study established that low dose exposures induced toxicity to the HT-22 cell line during 8days. The results indicates potency dependent response, the toxicity of single metals on the HT-22 cells; MeHg > As > Cd > Pb. The

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Sandberg, Maxwell, Wyatt Whitman, Christina Ross, Matvey Tsivian, and Stephen Walker. "Pulsed electromagnetic field therapy's effect on bladder cancer cell line HT-1376." Journal of Clinical Oncology 42, no. 4_suppl (2024): 666. http://dx.doi.org/10.1200/jco.2024.42.4_suppl.666.

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666 Background: Pulsed electromagnetic field therapy (PEMF) is a magnetic waveform energy that can be targeted for delivery to cells and/or patients. It is noninvasive, and to date no reported negative side effects exist. Recently, its use as a therapeutic for cancer has come into focus. However, to our knowledge, no study has examined the effect of PEMF on bladder cancer at the cellular level. In this study, we sought to examine how PEMF altered a bladder cancer cell line (HT-1376) at the genomic level. Methods: HT-1376 cells were cultured, and cells were plated into either a control plate (n

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Soylu, Sinan. "Crocus Officinalis (L.) Extract on Human Colerectal Cancer Cell Line (HT-22): Investigation in Vitro." Cumhuriyet Science Journal 45, no. 1 (2024): 35–39. http://dx.doi.org/10.17776/csj.1419826.

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Crocus sativus L. has been used as spice, food colouring and medicinal plant for thousands of years. In this study, antioxidant properties and cytotoxic effect of saffron extract were evaluated in HT-22 cell lines. Malignant and non-malignant cells (L929) were cultured in DMEM medium and incubated with different concentrations of saffron extract in different solvents (water, ethanol, ethyl-acetate, n-hexane). Cell viability was determined by MTT assay. Antioxidant parameters such as DPPH, FRAP, total polyphenol and flavonoid amounts were measured. The highest DPPH value was found as 15.90±0.12

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Karri, Venkatanaidu, Marta Schuhmacher, Vikas Kumar, David Ramos, and Eliandre De Oliveira Cacheado. "Proteomics approach for improving the mechanisms associated with MeHg toxicity in HT-22 hippocampal cell line." Toxicology Letters 280 (October 2017): S259. http://dx.doi.org/10.1016/j.toxlet.2017.07.920.

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Ji, Yang‐Fei, Dan Wang, Yan‐Ru Liu, Xing‐Rong Ma, Hong Lu, and Bo‐Ai Zhang. "MicroRNA‐132 attenuates LPS‐induced inflammatory injury by targeting TRAF6 in neuronal cell line HT‐22." Journal of Cellular Biochemistry 119, no. 7 (2018): 5528–37. http://dx.doi.org/10.1002/jcb.26720.

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8

Illmer, Christoph, Sibylle Madlener, Zsuzsanna Horvath, et al. "Immunologic and Biochemical Effects of the Fermented Wheat Germ Extract Avemar." Experimental Biology and Medicine 230, no. 2 (2005): 144–49. http://dx.doi.org/10.1177/153537020523000209.

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Avemar (MSC) is a nontoxic fermented wheat germ extract demonstrated to have antitumor effects. Avemar has the potential to significantly improve the survival rate in patients suffering from malignant colon tumors. We studied its effects in the HT-29 human colon carcinoma cell line. Avemar had an inhibiting effect on colonies of HT-29 cells with an IC50 value of 118 μg/ml (7 days of incubation); this value could be decreased to 100 and 75 μg/ml in the presence of vitamin C. In the cell line examined, Avemar induced both necrosis and apoptosis, as demonstrated by Hoechst/propldium iodide staini

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Rae, Julie, Jason Hackney, Kevin Huang, Mary Keir, and Ann Herman. "Identification of an IL-22-Dependent Gene Signature as a Pharmacodynamic Biomarker." International Journal of Molecular Sciences 22, no. 15 (2021): 8205. http://dx.doi.org/10.3390/ijms22158205.

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Interleukin-22 (IL-22) plays a role in epithelial barrier function and repair, and may provide benefits in conditions like inflammatory bowel disease. However, limited human data are available to assess the clinical effect of IL-22 administration. This study used a human intestinal cell line to identify an IL-22-dependent gene signature that could serve as a pharmacodynamic biomarker for IL-22 therapy. The response to IL-22Fc (UTTR1147A, an Fc-stabilized version of IL-22) was assessed in HT-29 cells by microarray, and the selected responsive genes were confirmed by qPCR. HT-29 cells demonstrat

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Betul, Danısman, and Cicek Betul. "Agomelatine protects hippocampal neurons against doxorubicin induced toxicity." GSC Biological and Pharmaceutical Sciences 24, no. 2 (2023): 290–96. https://doi.org/10.5281/zenodo.10440942.

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Doxorubicin (DOX) is a powerful chemotherapy drug used in numerous cancer treatments, known to causes neurotoxicity and impair cognitive function in cancer patients. The main mechanism thought to be responsible for the neuronal damage related to chemotherapy is oxidative stress. Agomelatine (AGM) has recently been identified as a neuroprotective agent against toxicity and the effect of AGM on DOX-induced neurotoxicity was investigated in this study. In order to evaluate the effect of AGM on oxidative stress and apoptosis, malondialdehyde (MDA), lactate dehydrogenase (LDH), superoxide dismutase

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11

Mohamed, Hiba Hashim Mahgoub, Amna Bint Wahab Elrashid Mohammed Hussien, and Ahmed Elsadig Mohammed Saeed. "QSAR and docking studies of pyrazole analogs as antiproliferative against human colorectal adenocarcinoma cell line HT-29." European Journal of Chemistry 13, no. 3 (2022): 319–26. http://dx.doi.org/10.5155/eurjchem.13.3.319-326.2259.

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In-silico quantitative structure-activity relationship (QSAR) study was performed to develop a model on a series of novel pyrazole derivatives containing acetamide moiety which exhibited considerable antiproliferative activity against human colorectal adenocarcinoma cell line HT-29. The model obtained has a correlation coefficient (r) of 0.9693, squared correlation coefficient (r2) of 0.9395 and a leave-one-out (LOO) cross-validation coefficient (Q2) value of 0.8744. The predictive power of the developed model was confirmed by the external validation which has an r2 value of 0.9488. These para

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Zhang, Lu, Yu Fang, Xuan Cheng та ін. "The Potential Protective Effect of Curcumin on Amyloid-β-42 Induced Cytotoxicity in HT-22 Cells". BioMed Research International 2018 (2018): 1–8. http://dx.doi.org/10.1155/2018/8134902.

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Background. We aimed to investigate the effect and mechanism of curcumin (CUR) in Alzheimer’s disease (AD).Methods. Mouse hippocampal neuronal cell line HT-22 was treated with Aβ1–42 and/or CUR, and then cell viability was evaluated by cell counting kit 8, Beclin-l level was detected using western blotting, and the formation of autophagosomes was observed by transmission electron microscopy (TEM). Furthermore, transcriptome sequencing and analysis were performed in cells with Aβ1–42 alone or Aβ1–42 + CUR.Results. Aβ1–42 treatment significantly inhibited cell viability compared with untreated c

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Yuan, Ruiying, Dan Gao, Guibing Yang, et al. "Oxysophocarpine Prevents the Glutamate-Induced Apoptosis of HT–22 Cells via the Nrf2/HO–1 Signaling Pathway." Current Issues in Molecular Biology 46, no. 11 (2024): 13035–49. http://dx.doi.org/10.3390/cimb46110777.

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Oxysophocarpine (OSC), a quinolizidine alkaloid, shows neuroprotective potential, though its mechanisms are unclear. The aim of the present study was to investigate the neuroprotective effects of OSC through the nuclear factor erythroid 2−related factor 2 (Nrf2)/ heme oxygenase−1 (HO–1) signaling pathway using the HT–22 cell line. Assessments of cell viability were conducted utilizing the 3−(4,5−dimethylthiazol−2−yl)−2,5−diphenyltetrazolium bromide (MTT) assay. Assessments of oxidative stress (OS) were conducted through the quantification of reactive oxygen species (ROS). The integrity of the

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Epperla, Narendranath, Natalie Grover, Pallawi Torka, et al. "Evaluation of Risk Factors for Histological Transformation in Patients with Marginal Zone Lymphoma (MZL): Results from a Multicenter Cohort Study." Blood 144, Supplement 1 (2024): 2344. https://doi.org/10.1182/blood-2024-202721.

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Introduction Although MZL is an indolent B-cell lymphoma typically associated with excellent overall survival (OS), a subgroup of patients (pts) experience histological transformation (HT) to an aggressive lymphoma, significantly compromising their OS. Prior studies evaluating risk factors for HT largely lacked MZL-specific clinicopathological factors such as the presence of monoclonal (M-) protein, large B-cell (LC) content in the tumor, and Ki67 expression. Attainment of complete response (CR) to first-line therapy was associated with a lower risk of HT in a single-center retrospective study

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Kim, In Young, Jong Min Kim, Hyo Lim Lee, et al. "Neuroprotective effect of Aster yomena ethanolic extract in HT-22 and SK-N-MC cells based on antioxidant activity." Food Science and Preservation 31, no. 1 (2024): 99–111. http://dx.doi.org/10.11002/fsp.2024.31.1.99.

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The antioxidant potentials of ethanolic extracts derived from Aster yomena (A. yomena) were evaluated by assessing their total phenolic and flavonoid contents and radical scavenging activities. Our findings revealed that the 60% ethanolic extract of A. yomena exhibited the most robust antioxidant properties among all extracts tested. Specifically, the IC50 values for the 2,2′-azino-bis (3-ethyl benzothiazoline-6-sulfonic acid) and 1,1-diphenyl-2-picrylhydrazyl radical scavenging activities of the 60% ethanolic extract from A. yomena were determined to be 1,640.30 μg/mL and 2,655.10 μg/mL, resp

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Rusiecka, Izabela, Iwona Gągało, and Ivan Kocić. "Neuroprotective Activity of a Non-Covalent Imatinib+TP10 Conjugate in HT-22 Neuronal Cells In Vitro." Pharmaceutics 16, no. 6 (2024): 778. http://dx.doi.org/10.3390/pharmaceutics16060778.

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This study evaluated the probable relevance of a non-covalent conjugate of imatinib with TP10 in the context of a neuroprotective effect in Parkinson’s disease. Through the inhibition of c-Abl, which is a non-receptor tyrosine kinase and an indicator of oxidative stress, imatinib has shown promise in preclinical animal models of this disease. The poor distribution of imatinib within the brain tissue triggered experiments in which a conjugate was obtained by mixing the drug with TP10, which is known for exhibiting high translocation activity across the cell membrane. The conjugate was tested on

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Han, Bin, Hui Zhao, Xingji Gong та ін. "Upregulation of PGC-1α Attenuates Oxygen-Glucose Deprivation-Induced Hippocampal Neuronal Injury". Neural Plasticity 2022 (9 червня 2022): 1–10. http://dx.doi.org/10.1155/2022/9682999.

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Hippocampal neuronal damage likely underlies cognitive impairment in vascular dementia (VaD). PPARγ coactivator-1α (PGC-1α) is a master regulator of mitochondrial biogenesis. However, the role and the precise mechanism of how PGC-1α alleviates hippocampal neuronal injury remain unknown. To address this question, HT-22 cells, an immortalized hippocampal neuron cell line, with or without PGC-1α overexpression were subjected to oxygen-glucose deprivation (OGD), which mimics the circumstance of chronic cerebral hypoperfusion in VaD. After OGD, cell viability was assessed using the MTS assay. The m

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ADLERBERTH, I., C. SVANBORG, B. CARLSSON, et al. "P fimbriae and other adhesins enhance intestinal persistence of Escherichia coli in early infancy." Epidemiology and Infection 121, no. 3 (1998): 599–608. http://dx.doi.org/10.1017/s0950268898001137.

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Resident and transient Escherichia coli strains were identified in the rectal flora of 22 Pakistani infants followed from birth to 6 months of age. All strains were tested for O-antigen expression, adhesin specificity (P fimbriae, other mannose-resistant adhesins or type 1 fimbriae) and adherence to the colonic cell line HT-29. Resident strains displayed higher mannose- resistant adherence to HT-29 cells, and expressed P fimbriae (P=0·0036) as well as other mannose-resistant adhesins (P=0·012) more often than transient strains. In strains acquired during the first month of life, P fimbriae wer

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Couto, Marcos, Catalina Alamón, María García, et al. "Closo-Carboranyl- and Metallacarboranyl [1,2,3]triazolyl-Decorated Lapatinib-Scaffold for Cancer Therapy Combining Tyrosine Kinase Inhibition and Boron Neutron Capture Therapy." Cells 9, no. 6 (2020): 1408. http://dx.doi.org/10.3390/cells9061408.

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One of the driving forces of carcinogenesis in humans is the aberrant activation of receptors; consequently, one of the most promising mechanisms for cancer treatment is receptor inhibition by chemotherapy. Although a variety of cancers are initially susceptible to chemotherapy, they eventually develop multi-drug resistance. Anti-tumor agents overcoming resistance and acting through two or more ways offer greater therapeutic benefits over single-mechanism entities. In this study, we report on a new family of bifunctional compounds that, offering the possibility of dual action (drug + radiother

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Majrashi, Mohammed, Mansour Altukri, Sindhu Ramesh та ін. "𝜷-hydroxybutyric acid attenuates oxidative stress and improves markers of mitochondrial function in the HT-22 hippocampal cell line". Journal of Integrative Neuroscience 20, № 2 (2021): 321. http://dx.doi.org/10.31083/j.jin2002031.

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Karri, Venkatanaidu, Vikas Kumar, David Ramos, Eliandre Oliveira, and Marta Schuhmacher. "Comparative In Vitro Toxicity Evaluation of Heavy Metals (Lead, Cadmium, Arsenic, and Methylmercury) on HT-22 Hippocampal Cell Line." Biological Trace Element Research 184, no. 1 (2017): 226–39. http://dx.doi.org/10.1007/s12011-017-1177-x.

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Durot, Eric, Cecile Tomowiak, Anne-Sophie Michallet, et al. "Retrospective Analysis of 56 Cases of Transformed Waldenström Macroglobulinemia. a Study on Behalf of the French Innovative Leukemia Organization (FILO)." Blood 128, no. 22 (2016): 2982. http://dx.doi.org/10.1182/blood.v128.22.2982.2982.

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Abstract Introduction : Histologic transformation (HT) to an aggressive non-Hodgkin lymphoma is a well-described event in the natural history of patients with indolent lymphomas, mainly follicular lymphomas and chronic lymphocytic leukemia/small lymphocytic lymphoma. HT has been reported also in lymphoplasmacytic lymphoma (LPL)/Waldenström macroglobulinemia (WM) but only case reports or small patients series are available. Material and methods : We retrospectively searched the databases of 14 French and Belgian centers for patients with sequential or simultaneous diagnosis of LPL/WM and diffus

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Taşkıran, Ahmet Şevki, and Ayşe Topçu. "Investigation of the Protective Role of Quercetin on Oxidative Stress and Endoplasmic Stress Pathway in 4-aminopyridine-induced Neuronal Damage." Turkish Journal of Agriculture - Food Science and Technology 11, s1 (2023): 2505–11. http://dx.doi.org/10.24925/turjaf.v11is1.2505-2511.6413.

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Quercetin (QU) is a flavonoid found in different fruits and vegetables. Studies report that QU may have positive effects on neurological diseases. However, the effect of QU on 4-aminopyridine (4-AP)-induced neurodegeneration in neuronal cells is still not fully elucidated. In this study, the effects of QU on 4-AP-induced hippocampal neuron damage in vitro and the possible role of oxidative stress and endoplasmic reticulum stress in this effect were investigated. The study was carried out using the HT-22 hippocampal neuronal cell line. The effect of pre-treatment with QU on cell viability after

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Taşkıran, Ahmet Şevki, and Tuğba Yıldız Asdemir. "Investigation of the Effect of Pumpkin (Cucurbita pepo L.) Seed Oil on Pentylenetetrazole-induced Neuronal Damage in HT-22 Cell Line." Turkish Journal of Agriculture - Food Science and Technology 11, s1 (2023): 2499–504. http://dx.doi.org/10.24925/turjaf.v11is1.2499-2504.6410.

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Recent studies have shown the positive effects of Cucurbita pepo L. (pumpkin) seed oil (PSO) in different disease models. However, the effect of PSO on neurological diseases has not been clarified yet. Therefore, this study aims to elucidate the effects of BBS on pentylenetetrazole (PTZ)-induced neuronal damage and the possible roles of oxidative and nitrosative stress in this effect in vitro. The HT-22 hippocampal neuronal cell line was used in the study. Cell survival after PTZ-induced neuronal damage was evaluated with the XTT test in the groups. While the effects of BBS on total antioxidan

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Ramos, Patrícia, Marcos Schmitz, Daza Filgueira, et al. "Interaction of single-walled carbon nanotubes and saxitoxin: Ab initio simulations and biological responses in hippocampal cell line HT-22." Environmental Toxicology and Chemistry 36, no. 7 (2016): 1728–37. http://dx.doi.org/10.1002/etc.3544.

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Rusconi, Chiara, Maria Luisa Guerrera, Alessandra Tedeschi, et al. "Outcome of Transformed Marginal Zone Lymphomas Treated in the Rituximab Era." Blood 126, no. 23 (2015): 5098. http://dx.doi.org/10.1182/blood.v126.23.5098.5098.

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Abstract Introduction: Transformation of Marginal Zone Lymphoma (MZL) into an aggressive histology is uncommon phenomenon that can occur at any time after diagnosis and is expected to have a detrimental impact on prognosis. Biological and clinical knowledge on transformed Marginal Zone Lymphoma (tMZL) is poor and no standard treatment is established in the Rituximab era for these patients (pts). We retrospectively analyzed all consecutive biopsy proven tMZL in two Italian Hematological Divisions from 2002 to 2014 and we focused on post-transformation treatment and outcome. Methods: The dataset

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Nagai, Takashi, Noriyasu Kawai, Masakazu Gonda, et al. "Role of HIKESHI on Hyperthermia for Castration-Resistant Prostate Cancer and Application of a Novel Magnetic Nanoparticle with Carbon Nanohorn for Magnetic Hyperthermia." Pharmaceutics 15, no. 2 (2023): 626. http://dx.doi.org/10.3390/pharmaceutics15020626.

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The prognosis of castration-resistant prostate cancer (CRPC) is technically scarce; therefore, a novel treatment for CRPC remains warranted. To this end, hyperthermia (HT) was investigated as an alternative therapy. In this study, the analysis focused on the association between CRPC and heat shock protein nuclear import factor “hikeshi (HIKESHI)”, a factor of heat tolerance. Silencing the HIKESHI expression of 22Rv1 cells (human CRPC cell line) treated with siRNAs inhibited the translocation of heat shock protein 70 from the cytoplasm to the nucleus under heat shock and enhanced the effect of

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Petrone Arifa, Isabela, and Lucas Daniel Udovin. "Systematic review of neuroprotective actions of the ECP in the HT-22 neuronal line subjected to hypoxia and reoxygenation." Interdisciplinary Rehabilitation / Rehabilitacion Interdisciplinaria 6 (January 1, 2026): 15. https://doi.org/10.56294/ri202615.

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Background: Palmitoylethanolamide (PEA) is an endogenous fatty acid amide that has recognized anti-inflammatory and analgesic actions. Given that inflammation, excitotoxicity, oxidation damage, and microvascular and blood-brain barrier dysfunction are neurodegenerative processes typical of cognitive impairment in diseases such as Alzheimer's and Parkinson's, it is considered possible that treatments with supplemental PEA can alleviate chronic pain and protect against neuronal damage. to the patient. The objective is to analyze neurodegenerative and anti-inflammatory protective actions of Palmi

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Lee, Dahae, Sanghee Shim, and Kisung Kang. "4,6′-Anhydrooxysporidinone from Fusarium lateritium SSF2 Induces Autophagic and Apoptosis Cell Death in MCF-7 Breast Cancer Cells." Biomolecules 11, no. 6 (2021): 869. http://dx.doi.org/10.3390/biom11060869.

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Previous studies have reported that 4,6′-Anhydrooxysporidinone (SSF2-2), isolated from Fusarium lateritium SSF2, has neuroprotective effects on the HT-22 hippocampal neuronal cell line. However, the anti-cancer effect of SSF2-2 remains unclear. Here, we examined the viability of MCF-7 human breast cancer cells treated with SSF2-2 or left untreated using a cell viability assay kit. The underlying molecular mechanism was further investigated by Western blotting and immunocytochemistry studies. The results demonstrated that SSF2-2 inhibited the viability of MCF-7 cells. Treatment with SSF2-2 incr

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Poejo, Joana, Yolanda Orantos-Aguilera, Francisco Javier Martin-Romero, Ana Maria Mata та Carlos Gutierrez-Merino. "Internalized Amyloid-β (1-42) Peptide Inhibits the Store-Operated Calcium Entry in HT-22 Cells". International Journal of Molecular Sciences 23, № 20 (2022): 12678. http://dx.doi.org/10.3390/ijms232012678.

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Dysregulation in calcium signaling pathways plays a major role in the initiation of Alzheimer’s disease (AD) pathogenesis. Accumulative experimental evidence obtained with cellular and animal models, as well as with AD brain samples, points out the high cytotoxicity of soluble small oligomeric forms of amyloid-β peptides (Aβ) in AD. In recent works, we have proposed that Aβ-calmodulin (CaM) complexation may play a major role in neuronal Ca2+ signaling, mediated by CaM-binding proteins (CaMBPs). STIM1, a recognized CaMBP, plays a key role in store-operated calcium entry (SOCE), and it has been

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Xu, Ying, Jianchun Pan, Ling Chen, et al. "Phosphodiesterase-2 inhibitor reverses corticosterone-induced neurotoxicity and related behavioural changes via cGMP/PKG dependent pathway." International Journal of Neuropsychopharmacology 16, no. 4 (2013): 835–47. http://dx.doi.org/10.1017/s146114571200065x.

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Abstract Phosphodiesterase 2 (PDE2) is an enzyme responsible for hydrolysis of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) to restrict intracellular signalling of these second messenger molecules. This study investigated how PDE2 inhibitor Bay 60-7550 affects the dysregulated glucocorticoid signalling in neuronal cells and regulates depressive behaviours after chronic stress in mice. We found that exposure of hippocampal neurons to corticosterone resulted in time- and concentration-dependent increases in PDE2 expression. These intriguing findings were confir

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Colenbier, Robin, Costanza E. Maurici, Ivana Gorbaslieva, et al. "Abstract B048: Long-term moderate hyperthermia induces apoptotic signaling and reduces chemoresistance in pancreatic cancer cells in vitro." Cancer Research 82, no. 22_Supplement (2022): B048. http://dx.doi.org/10.1158/1538-7445.panca22-b048.

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Abstract In recent years, hyperthermia (HT) is gaining popularity as a therapeutic modality that could potentiate other treatments such as chemotherapy. Although pre-clinical and clinical research do suggest a beneficial effect of moderate HT (41.5°C), more knowledge on the molecular mechanisms is required before it can be routinely implemented in the clinic. In brief, several commercially available PDAC cell lines were subjected exposed to increasing durations of HT at 41.5°C, ranging from for 6, 12, and to 24 hours. Following HT, the effects on apoptotic signaling and chemotherapy sensitivit

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Luttwak, Efrat, Annie Qiu, Michelle Okwali, et al. "Impact of Early Histological Transformation on Survival in Patients with Follicular Lymphoma." Blood 142, Supplement 1 (2023): 3023. http://dx.doi.org/10.1182/blood-2023-190325.

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Introduction: FL represents the second most common NHL with an indolent natural history and a median OS exceeding 20 y. Histologic transformation (HT) to an aggressive lymphoma is historically linked to poor outcomes with a median post-transformation survival of 2-5 y. EFS24 and POD24 are established adverse events indicating a poor overall survival. POD24 is associated with a higher incidence of HT following immunochemotherapy. However, the impact of HT within POD24 (HT24) remains unknown. Objective: Given the rarity of HT and the limited resources dedicated to this patient population, we aim

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Karri, Venkatanaidu, Vikas Kumar, David Ramos, Eliandre Oliveira, and Marta Schuhmacher. "An in vitro cytotoxic approach to assess the toxicity of heavy metals and their binary mixtures on hippocampal HT-22 cell line." Toxicology Letters 282 (January 2018): 25–36. http://dx.doi.org/10.1016/j.toxlet.2017.10.002.

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Pang, Qihua, Yanru Li, Lingxue Meng, Guanyong Li, Zhiwei Luo, and Ruifang Fan. "Neurotoxicity of BPA, BPS, and BPB for the hippocampal cell line (HT-22): An implication for the replacement of BPA in plastics." Chemosphere 226 (July 2019): 545–52. http://dx.doi.org/10.1016/j.chemosphere.2019.03.177.

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Bourhia, Mohammed, Kaoutar Bouothmany, Hanane Bakrim, et al. "Chemical Profiling, Antioxidant, Antiproliferative, and Antibacterial Potentials of Chemically Characterized Extract of Citrullus colocynthis L. Seeds." Separations 8, no. 8 (2021): 114. http://dx.doi.org/10.3390/separations8080114.

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Background: Citrullus colocynthis L. (C. colocynthis) is commonly known as colocynth. It belongs to the family Cucurbitaceae that is frequently used in alternative medicine in the north of Africa. The aim of the study: the present research was undertaken to investigate the chemical composition, antioxidant, antiproliferative, and antibacterial potentials of C. colocynthis seed extract. Material and methods: the chemical composition of C. colocynthis seed organic extract was characterized using gas chromatography/mass spectrometry (GC-MS). The antioxidant property was carried out using both β-c

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Epperla, Narendranath, Natalie S. Grover, Kaitlin Annunzio, et al. "Impact of Large Cells and Ki-67% on Outcomes in Patients with Newly Diagnosed Marginal Zone Lymphoma - Results from a Multicenter Cohort Study." Blood 142, Supplement 1 (2023): 266. http://dx.doi.org/10.1182/blood-2023-185152.

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Introduction Marginal zone lymphoma (MZL) is an indolent B-cell lymphoma primarily composed of small/medium cells with low proliferation. However, there are cases where large B-cells (LC) are increased on the biopsy or Ki-67 expression is higher. The significance of LC content and Ki-67 in MZL is uncertain compared to other lymphomas (e.g., follicular or mantle cell). Previous studies evaluating prognostic indices in MZL or the risk of histologic transformation (HT) to diffuse large B-cell lymphoma did not assess these factors. Clinicians and patients often have concerns about the meaning and

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Sand, P., T. Svenberg, and B. Rydqvist. "Carbachol induces oscillations in membrane potential and intracellular calcium in a colonic tumor cell line, HT-29." American Journal of Physiology-Cell Physiology 273, no. 4 (1997): C1186—C1193. http://dx.doi.org/10.1152/ajpcell.1997.273.4.c1186.

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The patch-clamp technique was used to study the effects of carbachol (CCh) on HT-29 cells. During CCh exposure, the cells ( n = 23) depolarized close to the equilibrium potential for Cl−([Formula: see text]; −48 mV) and the membrane potential then started to oscillate (16/23 cells). In voltage-clamp experiments, similar oscillations in whole cell currents could be demonstrated. The whole cell conductance increased from 225 ± 25 pS in control solution to 6,728 ± 1,165 pS (means ± SE, n = 17). In substitution experiments (22 mM Cl− in bath solution,[Formula: see text]= 0 mV), the reversal potent

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Tran, Phu, Montana Beeson, and Michael Georgieff. "Iron-Dependent Mechanism of Neuronal Bdnf Suppression by Cellular Iron Deficiency." Current Developments in Nutrition 4, Supplement_2 (2020): 1278. http://dx.doi.org/10.1093/cdn/nzaa058_036.

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Abstract Objectives Iron deficiency (ID) during neural development is associated with long-term neurocognitive dysfunction. In rodent models, the cognitive deficit is associated with reduced hippocampal brain-derived neurotrophic factor (Bdnf) expression in adulthood despite early iron treatment. Since a previous study suggested a role of epigenetic modifications at the Bdnf locus, we assessed whether an iron-dependent signaling pathway from ID → HIF1α → JARID1B (Fe-containing histone demethylase) → Bdnf is responsible for Bdnf suppression in iron-deficient neurons. The objective is to determi

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Ramos, Patrícia, Marcos Schmitz, Sibele Gama, et al. "Cytoprotection of lipoic acid against toxicity induced by saxitoxin in hippocampal cell line HT-22 through in silico modeling and in vitro assays." Toxicology 393 (January 2018): 171–84. http://dx.doi.org/10.1016/j.tox.2017.11.004.

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Nascimento da Cruz, Anne Cecília, Dalci José Brondani, Temístocles I´talo de Santana, et al. "Biological Evaluation of Arylsemicarbazone Derivatives as Potential Anticancer Agents." Pharmaceuticals 12, no. 4 (2019): 169. http://dx.doi.org/10.3390/ph12040169.

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Fourteen arylsemicarbazone derivatives were synthesized and evaluated in order to find agents with potential anticancer activity. Cytotoxic screening was performed against K562, HL-60, MOLT-4, HEp-2, NCI-H292, HT-29 and MCF-7 tumor cell lines. Compounds 3c and 4a were active against the tested cancer cell lines, being more cytotoxic for the HL-60 cell line with IC50 values of 13.08 μM and 11.38 μM, respectively. Regarding the protein kinase inhibition assay, 3c inhibited seven different kinases and 4a strongly inhibited the CK1δ/ε kinase. The studied kinases are involved in several cellular fu

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Kling, Beata, Daniel Bücherl, Peter Palatzky, et al. "Flavonoids, Flavonoid Metabolites, and Phenolic Acids Inhibit Oxidative Stress in the Neuronal Cell Line HT-22 Monitored by ECIS and MTT Assay: A Comparative Study." Journal of Natural Products 77, no. 3 (2013): 446–54. http://dx.doi.org/10.1021/np400518k.

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Zhang, Li, Dandan Li, Juan Zhang, et al. "Excessive apoptosis and ROS induced by ethionine affect neural cell viability and differentiation." Acta Biochimica et Biophysica Sinica 52, no. 10 (2020): 1156–65. http://dx.doi.org/10.1093/abbs/gmaa093.

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ABSTRACT The central nervous system (CNS) diseases are still a major cause of morbidity and mortality throughout the world, which imposes heavy burden on the development of society. Ethionine is a non-proteinogenic amino acid having similar chemical structure and activity to that of methionine, with which it competes. Previous studies have confirmed that ethionine affects various cellular functions by inhibiting the biosynthesis of proteins, RNA, DNA, and phospholipids, or all of them. The relationship of ethionine with some CNS diseases, including neural tube defects, has been investigated re

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Rollo, Ellen E., Scott J. Hempson, Ajay Bansal, et al. "The Cytokine Osteopontin Modulates the Severity of Rotavirus Diarrhea." Journal of Virology 79, no. 6 (2005): 3509–16. http://dx.doi.org/10.1128/jvi.79.6.3509-3516.2005.

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ABSTRACT Osteopontin (OPN) is a sialated phosphoprotein found in tissues and secreted into body fluids. It is an integrin ligand with pleiotropic functions as an extracellular matrix protein in mineralized tissues and a cytokine that is active in cell signaling (A. B. Tuck, C. Hota, S. M. Wilson, and A. F. Chambers, Oncogene 22:1198-1205, 2003). To determine whether OPN may be important in mucosal defense against viral pathogens, we evaluated the OPN response to rotavirus infection and the extent of diarrhea manifested by infected opn null mutant (opn − / −) mice. Reverse transcription-PCR, No

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Roayapalley, Praveen K., Hiroshi Sakagami, Keitaro Satoh, et al. "Cytotoxic Tumour-Selective 1,5-Diaryl-3-Oxo-1,4-Pentadienes Mounted on a Piperidine Ring." Medicines 8, no. 12 (2021): 78. http://dx.doi.org/10.3390/medicines8120078.

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A series of 3,5-bis(benzylidene)-4-piperidones 2a–u were prepared as candidate cytotoxic agents. In general, the compounds are highly toxic to human gingival carcinoma (Ca9-22), human squamous carcinoma-2 (HSC-2) and human squamous carcinoma-4 (HSC-4) neoplasms, but less so towards non-malignant human gingival fibroblast (HGF), human periodontal ligament fibroblast (HPLF) and human pulp cells (HPC), thereby demonstrating tumour-selective toxicity. A further study revealed that most of the compounds in series 2 were more toxic to the human Colo-205 adenocarcinoma cell line (Colo-205), human HT2

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Wijermans, P. W., L. van Egmond, P. F. Ypma, M. R. Schipperus, Jean-Louis Kerkhoffs, and L. H. Bohmer. "Isovolemic Erythrocytapheresis; Fixed Versus Patient Tailored Volume Exchange in Patients with Polycythemia or Hemochromatosis." Blood 108, no. 11 (2006): 4894. http://dx.doi.org/10.1182/blood.v108.11.4894.4894.

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Abstract Introduction: Conventional phlebotomy is the standard therapy to remove either erythrocytes or iron in patients with Polycythema Vera (and sec. polyglobulinemia) or patients with hemochromatosis (HC) (and iron overload). This treatment that should be repeated regular has its side effects, is often experienced as inconvenient by the patients and the desired effect is not always reached. We developed an erythrocytapheresis technique based on an isovolemic principle that can be used to remove larger amounts of erythrocytes and is experienced as more convient by the patients. Here we repo

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Lee, Richard S., Kellie L. K. Tamashiro, Xiaoju Yang, et al. "Chronic Corticosterone Exposure Increases Expression and Decreases Deoxyribonucleic Acid Methylation of Fkbp5 in Mice." Endocrinology 151, no. 9 (2010): 4332–43. http://dx.doi.org/10.1210/en.2010-0225.

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There is evidence for hypercortisolemia playing a role in the generation of psychiatric symptoms and for epigenetic variation within hypothalamic-pituitary-adrenal (HPA) axis genes mediating behavioral changes. We tested the hypothesis that expression changes would be induced in Fkbp5 and other HPA axis genes by chronic exposure to corticosterone and that these changes would occur through the epigenetic mechanism of loss or gain of DNA methylation (DNAm). We administered corticosterone (CORT) to C57BL/6J mice via their drinking water for 4 wk and tested for behavioral and physiological changes

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Rusconi, Chiara, Antonella Anastasia, Annalisa Chiarenza, et al. "Outcome of Transformed FL(t-FL) Worsens According to the Timing of Transformation and to the Number of Previous Therapies. A Survey of the Fondazione Italiana Linfomi (FIL)." Blood 126, no. 23 (2015): 3933. http://dx.doi.org/10.1182/blood.v126.23.3933.3933.

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Abstract Background: Histologic transformation (HT) refers to a biologic event leading to the development of a high grade non-Hodgkin lymphoma, mostly diffuse large B cell lymphoma (DLBCL), in patients (pts) with an underlying follicular lymphoma (FL), whose recently reported risk is 2% to 3% per year. The prognosis of t-FL has been considered historically very poor, but several studies in the Rituximab (RTX) era suggest that survival may be more favorable than previously recognized. The treatment approach for t-FL is often individualized and pts are generally excluded from clinical trials, so

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Durot, Eric, Damien Roos-Weil, Adrien Chauchet, et al. "CD19-Targeting CAR T-Cell Therapy in Transformed Waldenström Macroglobulinemia/Lymphoplasmacytic Lymphoma: A Descar-T and US Collaborative Study." Blood 142, Supplement 1 (2023): 616. http://dx.doi.org/10.1182/blood-2023-173988.

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Introduction: Patients with histological transformation (HT) of Waldenström macroglobulinemia (WM) who relapse or are refractory (R/R) have a poor prognosis with standard chemoimmunotherapy, notably patients who are unable to undergo high dose chemotherapy (HCT) and autologous stem cell transplantation (ASCT) or who relapse after HCT/ASCT. CD19-targeted chimeric antigen receptor (CAR) T-cell therapies can lead to durable responses in relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL) and thus may represent a promising therapeutic option in R/R transformed WM (tWM); however, data f

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Betul Danısman and Betul Cicek. "Agomelatine protects hippocampal neurons against doxorubicin induced toxicity." GSC Biological and Pharmaceutical Sciences 24, no. 2 (2023): 290–96. http://dx.doi.org/10.30574/gscbps.2023.24.2.0341.

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Doxorubicin (DOX) is a powerful chemotherapy drug used in numerous cancer treatments, known to causes neurotoxicity and impair cognitive function in cancer patients. The main mechanism thought to be responsible for the neuronal damage related to chemotherapy is oxidative stress. Agomelatine (AGM) has recently been identified as a neuroprotective agent against toxicity and the effect of AGM on DOX-induced neurotoxicity was investigated in this study. In order to evaluate the effect of AGM on oxidative stress and apoptosis, malondialdehyde (MDA), lactate dehydrogenase (LDH), superoxide dismutase

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