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1

Schupp, Sabine Sarrāj Muḥammad ibn Aḥmad. "Labsal dessen, der bei Tag und bei Nacht reist Ibn Māliḥs Uns as-sārī was-sārib, ein marokkanisches Pilgerbuch des frühen 17. Jahrhunderts /." Berlin : K. Schwarz, 1985. http://catalog.hathitrust.org/api/volumes/oclc/14718574.html.

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The author's Magisterarbeit--Universität Freiburg i. Br., 1984.<br>Includes selections of Muḥammad ibn Aḥmad Sarrāj's Uns al-sārī wa-al-sārib min aqṭār al-Maghārib ilá muntahá al-āmāl wa-al-maʼārib wa-sayyid al-aʻājim wa-al-Aʻārib in German translation. Includes indexes. Includes bibliographical references (p. 127-133).
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2

Quartel, Susanne. "Beachwatch : the effect of daily morphodynamics on seasonal beach evolution /." Utrecht : Royal Dutch Geographical Society/Faculty of Geosciences, Utrecht University, 2007. http://www.loc.gov/catdir/toc/fy0804/2008400361.html.

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3

Evertsson, Jens. "Är HTML 5 redo för användning? : - Fokus på funktionalitet gällande utvecklingsspråkets nya taggar och attribut." Thesis, Linnéuniversitetet, Institutionen för datavetenskap, fysik och matematik, DFM, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-16493.

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Det här arbetet innefattar html 5 i avseendet beträffande användning av dess nya taggar/attribut redan nu, även fastän år som 2022 eller 2014 har nämnts av vissa när det gäller utvecklingsspråkets färdigställande. Intresset bakom arbetet uppstod baserat på några olika saker. Först och främst vid studerandet inom kursen "Webbteknisk Introduktion" (som läses i samband med Webbprogrammerare-programmets första år (hösten 2009), hos Linnéuniversitet) där användning av nya taggar, och påståenden avseende att språket redan då kunde börja användas, samt även utvecklingsspråkets namn (eftersom innefatt
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4

Schwesig, Paul-Gerhard. "Die Rolle der Tag-JHWHs-Dichtungen im Dodekapropheton." Berlin New York de Gruyter, 2005. http://deposit.d-nb.de/cgi-bin/dokserv?id=2848367&prov=M&dok_var=1&dok_ext=htm.

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5

Beck, Martin. "Der "Tag YHWH's" im Dodekapropheton Studien im Spannungsfeld von Traditions- und Redaktionsgeschichte." Berlin New York de Gruyter, 2004. http://deposit.ddb.de/cgi-bin/dokserv?id=2672353&prov=M&dok_var=1&dok_ext=htm.

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6

Beck, Martin. "Der "Tag YHWHs" im Dodekapropheton : Studien im Spannungsfeld von Traditions- und Redaktionsgeschichte /." Berlin [u.a.] : de Gruyter, 2005. http://deposit.ddb.de/cgi-bin/dokserv?id=2672353&prov=M&dokv̲ar=1&doke̲xt=htm.

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7

Li, Bin. "Tang dai wen ming yu xin wen chuan bo." Beijing : Xin hua chu ban she, 1999. http://catalog.hathitrust.org/api/volumes/oclc/45471925.html.

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8

Blumenthal, Christian. ""Es wird aber kommen der Tag des Herrn" eine textkritische Studie zu 2Petr 3,10." Hamburg [Berlin] Philo, 2004. http://deposit.d-nb.de/cgi-bin/dokserv?id=2912717&prov=M&dok_var=1&dok_ext=htm.

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9

Blumenthal, Christian. ""Es wird aber kommen der Tag des Herrn" : eine textkritische Studie zu 2Petr 3,10 /." Hamburg : Philo & Philo Fine Arts, 2007. http://deposit.d-nb.de/cgi-bin/dokserv?id=2912717&prov=M&dok_var=1&dok_ext=htm.

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10

Müller-Roth, Marcus. "Das Buch vom Tage /." Fribourg : Acad. Press Fribourg [u.a.], 2008. http://deposit.d-nb.de/cgi-bin/dokserv?id=3154518&prov=M&dokv̲ar=1&doke̲xt=htm.

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11

Standaert, N. He Lixia. "Ke qin de Tian zhu Qing chu Jidu tu lun "di" tan "Tian" /." Taibei Shi : Guang qi chu ban she, 1998. http://catalog.hathitrust.org/api/volumes/oclc/49256108.html.

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12

Liu, Zhangzhang. "Tang dai Chang'an de ju min sheng ji yu cheng shi zheng ce /." Taibei Shi : Wen jin chu ban she, 2006. http://www.loc.gov/catdir/toc/chi0701/2007320257.html.

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Originally presented as the author's thesis (Ph. D.--University of Hong Kong) under the title: Tang dai shou du Chang'an de ju min sheng ji yu cheng shi zheng ce yan jiu.<br>Includes bibliographical references (p. 330-390).
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13

Liu, Yading. "Fo jiao ling yan ji yan jiu yi Jin Tang wei zhong xin /." Chengdu Shi : Sichuan chu ban ji tuan Ba Shu shu she, 2006. http://catalog.hathitrust.org/api/volumes/oclc/71742325.html.

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Revision and expansion of the author's Thesis (Ph. D.--Sichuan da xue, 2003).<br>"Sichuan da xue shi wu '211 gong cheng' zhong dian jian she xue ke xiang mu." 880-07 Includes bibliographical references.
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14

Georg, Stefan. "Marphatan Thakali Untersuchungen zur Sprache des Dorfes Marpha im Oberen Kāli-Gaṇḍaki-Tal, Nepal /." München : LINCOM Europa, 1996. http://catalog.hathitrust.org/api/volumes/oclc/36293175.html.

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15

Adelodun, Aderonke. "Characterisation of Tau splicing factors in Alzheimer's disease." Thesis, King's College London (University of London), 2012. https://kclpure.kcl.ac.uk/portal/en/theses/characterisation-of-tau-splicing-factors-in-alzheimers-disease(75640d4d-dacd-44aa-b64c-f6e14c8b3d8a).html.

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Neurofibrillary tangles consist of hyperphosphorylated tau, one of the pathological hallmarks of Alzheimer’s disease (AD). Alternative splicing of the tau pre-mRNA produces six tau isoforms with or without exon 10 (E10); tau4R or tau3R, microtubule binding repeats respectively. In normal human brains the ratio of 4R/3R tau is approximately one. Aberrant E10 splicing is also observed in some sporadic AD cases as well as Pick’s disease. The rationale for this study is that abnormal splicing may predispose to neurological diseases such as AD either through abnormal expression and/or activity of s
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16

Lau, Hay Wun Dawn. "Functional implications of tau-fyn interactions in Alzheimer's disease." Thesis, King's College London (University of London), 2015. http://kclpure.kcl.ac.uk/portal/en/theses/functional-implications-of-taufyn-interactions-in-alzheimers-disease(aeca1cb8-3537-4d1b-86fb-15f81edf60b1).html.

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Alzheimer’s disease (AD) is characterised by neuropathological deposits of amyloid plaques and neurofibrillary tangles. In AD, tau is abnormally phosphorylated and forms aggregates which spread trans-synaptically throughout the brain. The non-receptor-associated tyrosine kinase fyn is up-regulated in a subset of tangle-bearing neurons in AD brain and fyn also phosphorylates tau. Most tau is axonally located, where it promotes microtubule stability. Both tau and fyn are found in dendrites, where they stabilise receptor complexes at the post-synaptic density. Tau is also trafficked to the plasma
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17

Jung, Chang-Hoon. "A study of the changing state-business relations in South Korea focusing on the Roh Tae Woo regime (1988-1993) /." Seoul, Korea : Graduate Institute of Peace Studies, Kyung Hee University, 1993. http://catalog.hathitrust.org/api/volumes/oclc/53805695.html.

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Thesis (Master of Political Science)--Kyung Hee University, 1993.<br>"Thesis presented to the Graduate Institute of Peace Studies, Kyung Hee University, Seoul, Korea in partial fulfillment of the requirement for the degree of Master of Political Science"--Added t.p. Includes bibliographical references (p. 95-100).
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18

Ramsay, Alice. "Scales and otoliths as biogeochemical tags of Salmo trutta L." Thesis, Bangor University, 2010. https://research.bangor.ac.uk/portal/en/theses/scales-and-otoliths-as-biogeochemical-tags-of-salmo-trutta(9207a44f-5fcf-4932-b726-f2df2df72d07).html.

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The potential for naturally occurring element concentrations and stable isotope ratios to provide biogeochemical tags of Sa/mo fruita, an andromous salmonid, was examined. Statistically significant differences were found in the concentrations of Li,Mg, Mn, Sr, Ba and Pb in the hydroxyapatite freshwater growth bands of wild Sa/mo fnltta scales collected from 12 catchments draining into the Irish Sea and Celtic Sea. However, only 50% of the fish studied could be correctly classified to their catchment of origin based on element concentrations in scales. The degree to which element concentrations
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19

Ohlsen, Veronica. "Tai Chi Chuan Körpertherapie und Bioenergetik ; eine überarbeitete Diplomarbeit." Berlin Pro Business, 2007. http://deposit.d-nb.de/cgi-bin/dokserv?id=2930790&prov=M&dok_var=1&dok_ext=htm.

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20

Chiu, King Pong. "Thomé H. Fang, Tang Junyi and the appropriation of Huayan thought." Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/thome-h-fang-tang-junyi-and-the-appropriation-of-huayan-thought(58b1d131-2940-4695-b834-c4f79443b4fa).html.

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This thesis examines the rationale behind the work of Thomé H. Fang 方東美 (Fang Dongmei, 1899-1977) and Tang Junyi 唐君毅 (1909-1978), two of the most important Confucian thinkers in twentieth-century China, who appropriated aspects of the medieval Chinese Buddhist school of Huayan to develop a response to the challenges of ‘scientism’, the belief, widespread in their times, that quantitative natural science is the only valuable part of human learning and the only source of truth. As the status of Confucianism in China had declined from the mid-nineteenth century, non-Confucian ideas were appropria
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21

Karlsson, Åsa. "Den jämlike undersåten Karl XII:s förmögenhetsbeskattning 1713 /." Uppsala : Stockholm, Sweden : S. Academiae Ubsaliensis ; Distributor, Almqvist & Wiksell International, 1994. http://catalog.hathitrust.org/api/volumes/oclc/31935379.html.

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22

Niblock, Michael. "A molecular analysis of the relation between TDP-43 and tau pathology." Thesis, King's College London (University of London), 2013. https://kclpure.kcl.ac.uk/portal/en/theses/a-molecular-analysis-of-the-relation-between-tdp43-and-tau-pathology(067c0efe-9aa5-483b-8988-400bdc7faa43).html.

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Tau is a microtubule associated protein found in inclusions in tauopathies including Alzheimer's disease. One known cause of neurodegeneration is an excess of exon 10 inclusion in tau mRNA which is caused by several mutations in the MAPT gene, encoding tau. Processing of the Amyloid Precursor Protein (APP) generates P- amyloid (Ap) peptides which are deposited as amyloid plaques in AD brain. APP transcripts containing alternatively spliced exon 7 are increased in AD brain and processing of APP exon 7 containing protein isoforms may result in increased AP production. Recently, the DNA and RNA-
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23

Vouri, Mikaella. "The role of TAM receptors in brain tumour cell signalling and behaviour." Thesis, University of Portsmouth, 2016. https://researchportal.port.ac.uk/portal/en/theses/the-role-of-tam-receptors-in-brain-tumour-cell-signalling-and-behaviour(df1c22b0-d917-4960-a96d-49ed30a3e91d).html.

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Tumour invasion is the key element in the high rate of mortality and morbidity in glioma patients. Increased expression, in neoplastic cells, of receptor tyrosine kinases (RTKs) of the TAM family (comprising Tyro3, Axl and MerTK), has been reported in several cancers including gliomas, in which they play a key role in tumour invasion. Axl RTK, with molecular weight of 120-140 kDa, mediates glioma cell adhesion and invasion through a variety of ways. Within the scope of this thesis, Western blotting, quantitative polymerase chain reaction (qRT-PCR) and glioblastoma multiforme (GBM) tissue micro
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24

Povellato, Giulia. "Using Drosophila to study the contribution of human kinases to tau toxicity." Thesis, King's College London (University of London), 2012. https://kclpure.kcl.ac.uk/portal/en/theses/using-drosophila-to-study-the-contribution-of-human-kinases-to-tau-toxicity(9b2e6646-c686-44b7-bf2d-8d0e0f079f9e).html.

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The major neuropathological feature associated with tauopathies is the aggregation of the microtubule associated protein tau within neurons. Aberrant phosphorylation events on tau contribute to the aggregation during disease. The kinases and the phosphorylation sites on tau responsible for the generation of pathogenic tau forms are still unclear. My thesis proposes to establish a Drosophila model to investigate the human kinases and phosphorylation sites responsible for the generation of human tau toxicity. Expression of human tau in the photoreceptors of transgenic Drosophila leads to a degen
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Ishak, Abdul Kadir. "Suspended sediment dynamics and flux in the macrotidal Taf estuary, South Wales." Thesis, Bangor University, 1997. https://research.bangor.ac.uk/portal/en/theses/suspended-sediment-dynamics-and-flux-in-the-macrotidal-taf-estuary-south-wales(2a686e53-be86-4731-ac19-aa998d5400ba).html.

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26

Brotherton, Elizabeth Chipman. "Li Kung-lin and long handscroll illustrations of Tʻao Chʻien's Returning home". Princeton, N.J. : Princeton University, 1992. http://catalog.hathitrust.org/api/volumes/oclc/37378045.html.

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27

Srubar, Helena. "Ambivalenzen des Populären : Pan Tau und Co. zwischen Ost und West /." Konstanz : UVK, 2008. http://deposit.d-nb.de/cgi-bin/dokserv?id=3045729&prov=M&dok_var=1&dok_ext=htm.

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28

Yang, Wan-Ching. "Search for MSSM Higgs Bosons in Tau final states with the Dzero detector." Thesis, University of Manchester, 2010. https://www.research.manchester.ac.uk/portal/en/theses/search-for-mssm-higgs-bosons-in-tau-final-states-with-the-dzero-detector(a85e2235-ea33-4d14-86ac-41020fd56d6a).html.

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The cross-section times branching ratio of the Higgs boson decaying to tau final state in the Standard Model (SM) is too small to play any role in the SM Higgs boson searches. This, however, is different in the Minimal Supersymmetric Standard Model (MSSM), which predicts two Higgs doublets leading to five Higgs bosons: a pair of charged Higgs boson; two neutral CP-even Higgs bosons (h,H) and a CP-odd Higgs boson (A). A search for the production of neutral Higgs bosons decaying into tau final states in ppbar collisions at a centre-of-mass energy of 1.96 TeV is presented in this thesis. One of t
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Wong, Shiu Hong Trevor. "Ground reaction forces and plantar pressure distribution generated by two Tai Chi movements." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/ground-reaction-forces-and-plantar-pressure-distribution-generated-by-two-tai-chi-movements(936b1205-59ce-49bf-adf4-2a198524babb).html.

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Tai Chi Chuan, Tai Chi (TC) in short, is a popular form of Chinese martial arts which have been practised by millions of people and provides various health benefits, such as improving balance control, strengthening leg muscles, reducing fear of falling, enhancing flexibility and many more. The American Geriatrics Society and the British Geriatrics Society have recommended TC as a suitable exercise for preventing falls of older people. However, it is not clear which TC components are the most effective for balance improvement. In addition, it is also unknown what differences in biomechanics asp
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Lee, Myon Woo. "Policy change and political leadership in Japan case studies of administrative reform and tax reform /." The Ohio State University, 1994. http://catalog.hathitrust.org/api/volumes/oclc/32057359.html.

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31

Noble, Elizabeth. "The molecular mechanisms linking amyloid-beta, the prion protein and tau in Alzheimer's disease." Thesis, University of Manchester, 2017. https://www.research.manchester.ac.uk/portal/en/theses/the-molecular-mechanisms-linking-amyloidbeta-the-prion-protein-and-tau-in-alzheimers-disease(42b9a7dc-961c-4572-94c7-2a7a73d00d45).html.

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Several lines of evidence suggest that the expression of the cellular prion protein (PrPC) is altered with age and in sporadic Alzheimer’s disease, however, published results have been contradictory. Furthermore, a relationship between the expression of PrPC and Tau has started to emerge. We have revealed a specific relationship between the expression of PrPC and Tau in neuroblastoma cell lines and transgenic mouse models. In addition, we identified that the expression levels of PrPC are reduced in multiple brain regions following the progression of sporadic Alzheimer’s disease. Furthermore, t
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Iankova, Natalia. "Neurodegenerative disease mechanisms induced by tau fragmentation in a novel model of human tauopathy." Thesis, King's College London (University of London), 2018. https://kclpure.kcl.ac.uk/portal/en/theses/neurodegenerative-disease-mechanisms-induced-by-tau-fragmentation-in-a-novel-model-of-human-tauopathy(36bfb370-064c-496d-910c-e53a17201177).html.

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The tauopathies comprise a broad group of neurodegenerative diseases that are characterised by pathological alterations of tau in the brain that lead to synaptic dysfunction, changes in neuronal bioenergetics and loss of neuronal connectivity. There is growing evidence that tau fragmentation may be at least in part responsible for the clinical presentation in these disorders. In particular, diseases in which four microtubule-binding repeat tau isoforms are overrepresented, such as progressive supranuclear palsy, exhibit a truncated form of wild-type tau (termed Tau35) that is absent from age-m
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Phillips, Emma Claire. "Investigating the contribution of astrocytes and neuroinflammation to pathological tau changes in Alzheimer's disease." Thesis, King's College London (University of London), 2017. https://kclpure.kcl.ac.uk/portal/en/theses/investigating-the-contribution-of-astrocytes-and-neuroinflammation-to-pathological-tau-changes-in-alzheimers-disease(d96f6fa6-6870-4461-82b2-0a19d5507eab).html.

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Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterised by accumulation of ß-amyloid in extracellular plaques, intracellular neurofibrillary tangles composed of abnormally phosphorylated and aggregated tau, and widespread synaptic dysfunction and neuron loss that underlie the clinical symptoms of AD. Glial activation and a neuroinflammatory immune response is also a key aspect of the pathological progression of AD. The activation of astrocytes appears to be particularly associated with pathological changes in tau. This thesis aims to investigate the association betwee
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34

Marriott, Andrew Lewis. "The use of biogeochemical tags to determine the origins and movement patterns of fishes." Thesis, Bangor University, 2013. https://research.bangor.ac.uk/portal/en/theses/the-use-of-biogeochemical-tags-to-determine-the-origins-and-movement-patterns-of-fishes(e0773eac-df55-4d27-a937-7dabb35080b9).html.

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The incorporation of both trace and minor-trace elements within the otolith aragonite matrix of hatchery reared sea bass Dicentrarchus labrax and the possible effects of post mortem handling, transportation and the period of time whole fish were stored frozen were examined. Fmihennore, the possible effects of temporal variability of the water chemistry within two nursery grounds and the effect on the elemental concentrations within otoliths were measured. Finally, the use of naturally occurring trace and minor-trace elements incorporated within the otolith structures of teleost fish and their
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Kazemi, Mohsen. "What makes a successful sparing Taekwondo athlete?" Thesis, University of South Wales, 2017. https://pure.southwales.ac.uk/en/studentthesis/what-makes-a-successful-sparing-taekwondo-athlete(bbc5deb0-c4ec-4c6b-9a53-9a31dcdd41c1).html.

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Taekwondo (TKD), a Korean striking martial art, has become one of the most popular martial arts since its inclusion in 2000 Olympic Games. Having practiced TKD as an athlete and provided care as a health professional for decades, I investigated a series of features of the Olympic TKD athlete including: profile, injury rate and distribution, weight cycling/cutting and each of their relationships to success in terms of gaining a medal. My studies (Kazemi et al. 2006; Kazemi, Perri and Casella, 2009; Kazemi et al. 2010; Kazemi et al. 2013; Kazemi et al. 2014; Kazemi et al. 2015; Kazemi and Pieter
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Begley, Leonard J. "U.S. commercial banks' tax positions and their impact on South American lending." New York : Garland Pub, 1989. http://catalog.hathitrust.org/api/volumes/oclc/20013202.html.

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Bondulich, Marie Katrin. "Cleaved tau derived from human tauopathy brain induces disease-associated deficits in a novel mouse model." Thesis, King's College London (University of London), 2016. https://kclpure.kcl.ac.uk/portal/en/theses/cleaved-tau-derived-from-human-tauopathy-brain-induces-diseaseassociated-deficits-in-a-novel-mouse-model(682bb5b0-e450-406f-8ebc-9f9027a358cf).html.

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Human neurodegenerative tauopathies exhibit pathological tau aggregates in the brain along with diverse clinical features including cognitive and motor dysfunction. Post-translational modifications of tau, including tau phosphorylation and truncation, are characteristic features of human tauopathy. We previously identified a highly phosphorylated and truncated form of tau associated with the development of disease in humans. We have generated a new mouse model of tauopathy in which this human brain-derived, tau fragment (Tau35) is expressed under the control of the human tau promoter. Notably,
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Bin, Tayib Mahamad. "The determinants of assessment tax collection : the Malaysian local authority experience." Thesis, University of South Wales, 1998. https://pure.southwales.ac.uk/en/studentthesis/the-determinants-of-assessment-tax-collection-the-malaysian-local-authority-experience(3353ad69-5fb6-4b06-99be-f98c72821789).html.

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The increasing level of non-compliance with payment demands for local property taxes by Malaysian local authority taxpayers over the past decade has given rise to the need to study the efficiency and productivity of the tax administration system a high priority. This important and sensitive issue has not been given the attention that it deserves. Little empirical research on the administration of, and voluntary compliance in, the Malaysian local taxation system been undertaken and this has shaped the motivation for this study, which represents the first detailed analysis of these issues. Studi
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Suter, Louise. "A search for Higgs bosons in final states with multiple tau leptons at the DZero experiment." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/a-search-for-higgs-bosons-in-final-states-with-multiple-tau-leptons-at-the-dzero-experiment(f7dcbe1a-bd3f-489e-9b30-fe648d2dc353).html.

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Two searches for the production of Higgs bosons decaying into tau and mu leptons, using data collected with the DZero detector at the Fermilab Tevatron p-bar(p)collider, are presented. A search for the pair production of doubly charged Higgs bosons in the processq-bar(q) to H^{++}H^{--}, where H^{++} decays to tau-tau, mu-mu or tau-mu lepton pairs, with an integrated luminosity of up to L= 7.0 fb^{-1}, is presented. No significant excess of data over the expected SM background is observed and the results are used to set 95\% C.L. limits on the pair production cross section of doubly charged Hi
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Damjanovic, Tatiana. "Essays in public finance." Doctoral thesis, Stockholm : Economic Research Institute, Stockholm School of Economics (EFI), 2002. http://www.hhs.se/efi/summary/597.htm.

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Al-Kotaji, Myasar. "The multifunctional peptide, Tat-LK15 : a study of its cellular uptake and its potential use in drug delivery." Thesis, University of Manchester, 2012. https://www.research.manchester.ac.uk/portal/en/theses/the-multifunctional-peptide-tatlk15a-study-of-its-cellular-uptake-and-its-potential-use-in-drug-delivery(92514766-2626-4949-8e02-ca77dc88ff7b).html.

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Cell penetrating peptides (CPPs) have been used in many areas of drug delivery for mediating the delivery of peptides, protein, DNA, siRNA and liposomes. Additionally they have shown an ability to overcome drug resistance in cells enhancing chemotherapeutic activity. Our group has recently designed a promising multifunctional peptide, Tat-LK15, originating from the fusion of Tat peptide (49-57) with the synthetic amphipathic peptide, LK15. TAT-LK15 was found to be efficient at mediating DNA and siRNA delivery to cells especially contributing to the silencing of bcr-abl oncoprotein over a long
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42

Morat, Daniel. "Von der Tat zur Gelassenheit konservatives Denken bei Martin Heidegger, Ernst Jünger und Friedrich Georg Jünger ; 1920 - 1960." Göttingen Wallstein-Verl, 2007. http://deposit.d-nb.de/cgi-bin/dokserv?id=2881392&prov=M&dok_var=1&dok_ext=htm.

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Hjelström, Tomas. "The closed-end investment company premium puzzle : model development and empirical tests on Swedish and British data /." Stockholm : Economic Research Institute, Stockholm School of Economics [Ekonomiska forskningsinstitutet vid Handelshögskolan i Stockholm] (EFI), 2007. http://www2.hhs.se/EFI/summary/723.htm.

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Arthanari, Yamini. "Study of cellular delivery of siRNA and shRNA targeting bcr-abl in chronic myeloid leukemia using Tat derived peptide." Thesis, University of Manchester, 2011. https://www.research.manchester.ac.uk/portal/en/theses/study-of-cellular-delivery-of-sirna-and-shrna-targeting-bcrabl-in-chronic-myeloid-leukemia-using-tat-derived-peptide(b5d29b05-e140-4e85-a411-9e6ac40d3541).html.

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Chronic Myeloid Leukemia is characterised by the formation of a fusion gene bcr-abl. The gene product BCR-ABL has deregulated tyrosine kinase activity that plays a direct role in the pathogenesis of the disease. Recently, use of siRNA in leukaemic cells has led to effective gene silencing of bcr-abl. Gene delivery systems like viral vectors, electroporation and lipid based vectors have showed varying efficiencies but are limited by their level of toxicity and immunogenicity. Developments in the field of Cell Penetrating Peptides have shown effective cellular uptake of nucleic acids and protein
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Guo, Yue. "Capability assessment of VAr support and demand response to transmission network using flexible tap changing techniques in distribution networks." Thesis, University of Manchester, 2017. https://www.research.manchester.ac.uk/portal/en/theses/capability-assessment-of-var-support-and-demand-response-to-transmission-network-using-flexible-tap-changing-techniques-in-distribution-networks(5a373163-d2c9-4e13-9720-0c4fa0456c3f).html.

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Due to the increasing integration of renewable energy generations, the overvoltage and overload issues in transmission networks have become more significant, and they may occur at various locations. To mitigate the overvoltage issues, traditional solutions which often consider the installation of reactive power compensators such as shunt reactors, SVC, STATCOM may not be cost-effective. To mitigate the overload issues, traditional methods using direct or price-based demand control will affect customers’ electrical experience in that they are inconvenienced greatly. This thesis discusses the
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46

Harrison, Jonathan Robert. "Radiation damage studies in the LHCb VELO detector and searches for lepton flavour and baryon number violating tau decays." Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/radiation-damage-studies-in-the-lhcb-velo-detector-and-searches-for-lepton-flavour-and-baryon-number-violating-tau-decays(6a639716-f396-44b8-a509-61e309454d3d).html.

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This thesis presents work carried out using data from the LHCb experiment during the first three years of data taking, 2010 - 2012. A study of the effects of radiation damage on the silicon sensors of the LHCb Vertex Locator is performed, with an emphasis on the implications for the long term performance of the detector. Following three years of operation the sensors have received a maximum delivered neutron equivalent fluence of approximately 1.6E12 per square centimeter, leading to a number of radiation induced effects. In particular the change in charge collection efficiency and signal/nois
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Jaimes, Oscar O. "Construction and characterization of cDNA libraries bearing expressed sequence tags induced after treatment of Vicia faba leaves with saliylic acid." Berlin VWF, 2005. http://deposit.ddb.de/cgi-bin/dokserv?id=2709287&prov=M&dok_var=1&dok_ext=htm.

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Toloczko, Aleksandra. "Deubiquitination and control of the Hippo pathway." Thesis, University of Manchester, 2017. https://www.research.manchester.ac.uk/portal/en/theses/deubiquitination-and-control-of-the-hippo-pathway(8afdf3df-8635-4116-99c8-57fbe423501e).html.

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The Hippo signalling pathway is an evolutionarily conserved kinase cascade responsible for the cell proliferation, tissue growth and apoptosis during development and its dysregulation contributes to tumourigenesis. This signalling pathway was initially discovered in Drosophila and soon after that, it was shown to be highly conserved in mammals. The core Lats kinases of this tumour suppressive pathway phosphorylate and inhibit the downstream transcriptional co-activators YAP and TAZ, which are implicated in various cancers. Latest reports revealed various E3 ubiquitin ligases to negatively regu
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Font, Palma Carolina. "Modelling of gasification of poultry litter." Thesis, University of Manchester, 2012. https://www.research.manchester.ac.uk/portal/en/theses/modelling-of-gasification-of-poultry-litter(e4956eca-d310-4114-89a1-6f44af1aae27).html.

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The poultry industry in Europe is vast and proper waste management is required in order to comply with environmental regulations. As a result, poultry litter represents a potential fuel candidate for thermal conversion technologies since it is an available source. Therefore, a process for the gasification of poultry litter is examined in this study. This process integrates a fluidised bed gasifier with a gas turbine with the aim of generating combustibles gases for energy production. This resulted in a viable solution for a small scale system to be installed on-site the biomass source. The sys
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Bogue, Kelly Ann. "Precarious social housing : reforming policy, changing culture : an ethnographic case study of the impact of the 'Bedroom Tax'." Thesis, University of Manchester, 2017. https://www.research.manchester.ac.uk/portal/en/theses/precarious-social-housing-reforming-policy-changing-culture-an-ethnographic-case-study-of-the-impact-of-the-bedroom-tax(51e82538-d040-4a42-acc6-23d0a2c43f52).html.

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Through an ethnographic case study of one housing estate, this study explores the impact of the ‘Bedroom Tax’ on 31 social housing tenants. The research was motivated by three central questions: what impacts is the Bedroom Tax having on individuals and households? How is the policy rationalised? And, what impact is it having at the neighbourhood level? Previous research has shown the policy to be negatively impacting; financially, physically and psychologically. This study builds upon previous studies in highlighting how the increasing precariousness of social housing is producing housing inse
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