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Relevant bibliographies by topics / HTREK-1

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Academic literature on the topic 'HTREK-1'

Author: Grafiati

Published: 6 September 2023

Last updated: 31 July 2025

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Journal articles on the topic "HTREK-1"

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Wiedmann, Felix, Daniel Schlund, Francisco Faustino, et al. "N-Glycosylation of TREK-1/hK2P2.1 Two-Pore-Domain Potassium (K2P) Channels." International Journal of Molecular Sciences 20, no. 20 (2019): 5193. http://dx.doi.org/10.3390/ijms20205193.

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Mechanosensitive hTREK-1 two-pore-domain potassium (hK2P2.1) channels give rise to background currents that control cellular excitability. Recently, TREK-1 currents have been linked to the regulation of cardiac rhythm as well as to hypertrophy and fibrosis. Even though the pharmacological and biophysical characteristics of hTREK-1 channels have been widely studied, relatively little is known about their posttranslational modifications. This study aimed to evaluate whether hTREK-1 channels are N-glycosylated and whether glycosylation may affect channel functionality. Following pharmacological i

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2

Dallas, Mark L., Jason L. Scragg, and Chris Peers. "Modulation of hTREK-1 by carbon monoxide." NeuroReport 19, no. 3 (2008): 345–48. http://dx.doi.org/10.1097/wnr.0b013e3282f51045.

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Woo, JooHan, Young Keul Jeon, Yin-Hua Zhang, Joo Hyun Nam, Dong Hoon Shin, and Sung Joon Kim. "Triple arginine residues in the proximal C-terminus of TREK K+ channels are critical for biphasic regulation by phosphatidylinositol 4,5-bisphosphate." American Journal of Physiology-Cell Physiology 316, no. 3 (2019): C312—C324. http://dx.doi.org/10.1152/ajpcell.00417.2018.

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TWIK-related two-pore domain K+ channels (TREKs) are activated by acidic intracellular pH (pHi), membrane stretch, temperature, and arachidonic acid (AA). Phosphatidylinositol 4,5-bisphosphate (PIP2) exerts concentration-dependent biphasic regulations, which have been observed: inhibition by high PIP2, activation by partial decrease of PIP2, and inhibition by depletion of PIP2. Consistently, the stimulation of voltage-sensitive PIP2 phosphatase (Dr-VSP) induces initial activation and subsequent inhibition of TREKs. Lys in the proximal C-terminus (pCt) is responsible for the inhibition by high

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Mukherjee, Sourajit, and Sujit Sikdar. "Polymodal sensitivity of hTREK-1 channel to ischemia related factors." IBRO Reports 6 (September 2019): S361. http://dx.doi.org/10.1016/j.ibror.2019.07.1147.

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5

Miller, P., P. J. Kemp, A. Lewis, C. G. Chapman, H. J. Meadows, and C. Peers. "Acute hypoxia occludes hTREK-1 modulation: re-evaluation of the potential role of tandem P domain K+ channels in central neuroprotection." Journal of Physiology 548, no. 1 (2003): 31–37. http://dx.doi.org/10.1113/jphysiol.2003.040048.

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Enyeart, John J., and Judith A. Enyeart. "Ca2+ and K+ channels of normal human adrenal zona fasciculata cells: Properties and modulation by ACTH and AngII." Journal of General Physiology 142, no. 2 (2013): 137–55. http://dx.doi.org/10.1085/jgp.201310964.

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In whole cell patch clamp recordings, we found that normal human adrenal zona fasciculata (AZF) cells express voltage-gated, rapidly inactivating Ca2+ and K+ currents and a noninactivating, leak-type K+ current. Characterization of these currents with respect to voltage-dependent gating and kinetic properties, pharmacology, and modulation by the peptide hormones adrenocorticotropic hormone (ACTH) and AngII, in conjunction with Northern blot analysis, identified these channels as Cav3.2 (encoded by CACNA1H), Kv1.4 (KCNA4), and TREK-1 (KCNK2). In particular, the low voltage–activated, rapidly in

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7

El Hachmane, Mickael-F., Kathryn A. Rees, Emma L. Veale, Vadim V. Sumbayev та Alistair Mathie. "Enhancement of TWIK-related Acid-sensitive Potassium Channel 3 (TASK3) Two-pore Domain Potassium Channel Activity by Tumor Necrosis Factor α". Journal of Biological Chemistry 289, № 3 (2013): 1388–401. http://dx.doi.org/10.1074/jbc.m113.500033.

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TASK3 two-pore domain potassium (K2P) channels are responsible for native leak K channels in many cell types which regulate cell resting membrane potential and excitability. In addition, TASK3 channels contribute to the regulation of cellular potassium homeostasis. Because TASK3 channels are important for cell viability, having putative roles in both neuronal apoptosis and oncogenesis, we sought to determine their behavior under inflammatory conditions by investigating the effect of TNFα on TASK3 channel current. TASK3 channels were expressed in tsA-201 cells, and the current through them was

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8

Chen, X. J., W. Zheng, L. L. Chen, Z. B. Chen, and S. Q. Wang. "Telomerase antisense inhibition for the proliferation of endometrial cancer in vitro and in vivo." International Journal of Gynecologic Cancer 16, no. 6 (2006): 1987–93. http://dx.doi.org/10.1111/j.1525-1438.2006.00734.x.

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The objective of this study was to investigate the antitumor effect of antisense telomerase oligodeoxynucleotides to endometrial cancer cells in vitro and in vivo. Antisense oligodeoxynucleotides (ODNs) against the human telomerase transcripatse (hTERT) synthesized to serve as telomerase inhibitors. Reverse transcription–polymerase chain reaction and 3-[4,5-dimethylthiazol-2yl]-2,5-diphenyltetrazolium bromide (MTT) assay were used to test the expression of hTERT messengerRNA (mRNA) and inhibition of cell proliferation in vitro. In vivo, antitumor effects of ODNs or combined with cisplatin were

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9

Gil, V., D. Gallego, H. Moha Ou Maati, et al. "Relative contribution of SKCa and TREK1 channels in purinergic and nitrergic neuromuscular transmission in the rat colon." American Journal of Physiology-Gastrointestinal and Liver Physiology 303, no. 3 (2012): G412—G423. http://dx.doi.org/10.1152/ajpgi.00040.2012.

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Purinergic and nitrergic neurotransmission predominantly mediate inhibitory neuromuscular transmission in the rat colon. We studied the sensitivity of both purinergic and nitrergic pathways to spadin, a TWIK-related potassium channel 1 (TREK1) inhibitor, apamin, a small-conductance calcium-activated potassium channel blocker and 1H-[1,2,4]oxadiazolo[4,3-α]quinoxalin-1-one (ODQ), a specific inhibitor of soluble guanylate cyclase. TREK1 expression was detected by RT-PCR in the rat colon. Patch-clamp experiments were performed on cells expressing hTREK1 channels. Spadin (1 μM) reduced currents 1)

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Lee, Seungho, Guen Young Lee, Sujin Kim, Yong-Beom Park, and Han-Jun Lee. "Clinical utility of fat-suppressed 3-dimensional controlled aliasing in parallel imaging results in higher acceleration sampling perfection with application optimized contrast using different flip angle evolutions MRI of the knee in adults." British Journal of Radiology 93, no. 1112 (2020): 20190725. http://dx.doi.org/10.1259/bjr.20190725.

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Objective: To compare htree-dimensional CAIPIRINHA SPACE and two-dimensional turbo spin echo (2D TSE) MRI in the diagnosis of knee pathology in symptomatic adult patients. Methods: From February to September in 2018, 120 patients who underwent a knee MRI using both 3D CAIPIRINHA SPACE and 2D TSE MRI were enrolled. The signal-to-noise ratios (SNRs) and contrast-to-noise ratio (CNR) of the 2D and 3D MRI were compared using a paired t-test. Two radiologists independently evaluated both 2D and 3D MRI images using scoring systems for the menisci, ligaments, and cartilage. Intermethod, inter- and in

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Dissertations / Theses on the topic "HTREK-1"

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Mukherjee, Sourajit. "Single-channel studies on human TREK-1 (hTREK-1) channels to intracellular ischemia related factors." Thesis, 2020. https://etd.iisc.ac.in/handle/2005/5023.

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TREK-1, a member of the two-pore domain family of potassium channels, majorly contributes to the maintenance of resting membrane potential of a cell and has been reported to respond to ischemic levels of intracellular lactate and acidic pH to provide neuroprotection. There are two N-terminal variants that arise due to Alternative splicing: the shorter variant having a shorter N-terminus than the full-length human TREK-1 (hTREK-1) which is widely expressed in the acute hypoxia sensitive regions of the adult brain like the cerebellum and hippocampus and is upregulated under ischemia. Previ

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2

Choudhury, Nasreen. "G-Protein Coupled Estrogen Receptor (hGPER)- Mediated Action of 17β-Estradiol on hTREK-1 Potassium Channel". Thesis, 2017. http://etd.iisc.ac.in/handle/2005/4159.

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TREK-1 is a two-pore domain potassium channel that contributes to maintenance of the resting membrane potential of a cell. TREK-1 is involved in several physiological and pathophysiological conditions like nociception, anaesthesia, epilepsy, ischemia and depression. Activity of TREK-1 is modulated by a number of physical and chemical stimuli including the activation of G-protein coupled receptors by several neurotransmitters and hormones. An important modulator of neuronal activity and function is 17β-estradiol, which by acting through its classical receptors ERα and ERβ, can bring about genom

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Books on the topic "HTREK-1"

1

Weygandt, Jerry J. Accounting Principles with CD 6e Volume 1 and Peac Htree Complete Accounting Set. John Wiley & Sons Inc, 2001.

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