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1

Sono, Michelle Sutjiadi, and Listyo Yuwanto. "Kajian Budaya ‘Tea-Pai’ Dari Sudut Pandang Nilai Insani." PADARINGAN (Jurnal Pendidikan Sosiologi Antropologi) 7, no. 01 (2025): 14. https://doi.org/10.20527/pn.v7i01.14181.

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The Tea Pai procession has become one of the 13 essential wedding ceremonies in the Thiong Hua ethnic group, considered significant and irreplaceable despite the evolving times. This ceremony involves the immediate and extended families of the bride and groom, where respect, gifts, and well-wishes for the marriage are always present in the Tea Pai. This research delves deeper into the meaning behind this procession in terms of values, symbols, and communication. These three aspects are examined from the perspective of basic human values developed by Schwartz. The study employs a literature rev
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Fay, Jonathan. "“The Struggle to Live and Let Live …”." Ata: Journal of Psychotherapy Aotearoa New Zealand 17, no. 2 (2013): 173–81. http://dx.doi.org/10.9791/ajpanz.2013.16.

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This review offers a critique of Farhad Dalal’s article in this issue, an article which is based on his keynote address to the 2013 NZAP Conference. In this review article, I offer an appreciation for Farhad’s contribution, but also propose an alternative understanding of ethical discrimination. I suggest that psychotherapy is the child of Romanticism, in which it is axiomatic that intelligent empathy is better than observational rationality, and that equity is better than equality. The suffering of the oppressed is indeed privileged. The social, political, and therapeutic consequences of this
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3

Mair, Victor H. "Buddhism and the Rise of the Written Vernacular in East Asia: The Making of National Languages." Journal of Asian Studies 53, no. 3 (1994): 707–51. http://dx.doi.org/10.2307/2059728.

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The vast majority of premodern chinese literature, certainly all of the most famous works of the classical tradition, were composed in one form or another of Literary Sinitic (hereafter LS,wen-yen[-wen], also often somewhat ambiguously called “Classical Chinese” or “Literary Chinese”). Beginning in the medieval period, however, an undercurrent of written Vernacular Sinitic (hereafter VS,pai-hua[-wen])started to develop. The written vernacular came to full maturity in China only with the May Fourth Movement of 1919, after the final collapse during the 1911 revolution of the dynastic, bureaucrat
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4

Rewi, Poia. "He whakanui i ēnei tau, e rima tekau o Te Whare Wānanga o Waikato." Te Kōtihitihi : Ngā Tuhinga Reo Māori 3 (2016): 54–57. https://doi.org/10.15663/c45.36008.

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"Aku tau ki Waikato: 1986-2003 A Block Koia tērā, ko te Tari Māori (Māori Department), ko Timoti Kāretu te tumuaki, ko tōna kāhui kawe i ngā mahi ko te momo he wā tōna he pūkenga, he ahonuku, he ahorangi, he tākuta, he tohunga; he wā anō he pāpā, he whaea, he matua kēkē, he whaea kēkē; he wā anō he haututū, he hangarau, he whakatoi, he hoa tonu. Ko te tohu kē ia e whakaatuhia nei, ko te mātau o tēnei hanga ki te hāpai i te momo taera e hua ai te pai ki te ākonga, ki te mahi, ki te hapori. Koia hoki te momo e whakamātauhia ana e te ao Pākehā; te mōhio kē, te tirohanga kē, te pōhēhē, te ture, te
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5

Peng, Shuangzhou, Guangpu Xue, Lihu Gong, et al. "A long-acting PAI-1 inhibitor reduces thrombus formation." Thrombosis and Haemostasis 117, no. 07 (2017): 1338–47. http://dx.doi.org/10.1160/th16-11-0891.

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SummaryPlasminogen activator inhibitor 1 (PAI-1) is the main inhibitor of tissue-type and urokinase-type plasminogen activators (t/uPA) and plays an important role in fibrinolysis. Inhibition of PAI-1 activity prevents thrombosis and accelerates fibrinolysis, indicating that PAI-1 inhibitors may be used as effective antithrombotic agents. We previously designed a PAI-1 inhibitor (PAItrap) which is a variant of inactivated urokinase protease domain. In the present study, we fused PAItrap with human serum albumin (HSA) to develop a long-acting PAI-1 inhibitor. Unfortunately, the fusion protein P
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6

Bamrungwongtaree, Joompondej, and Mongkol Mongkolwongrojn. "Study Swaging Process for Reduction Swage Effect in Hard Disk Drive." Advanced Materials Research 677 (March 2013): 256–62. http://dx.doi.org/10.4028/www.scientific.net/amr.677.256.

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In hard disk drive manufacturing common uses ball swaging. It is a process that used to assemble a boss tower and an arm aperture. The swage ball has a larger diameter than an inner diameter of the boss tower. Application a compression force to the inner surface of the boss tower to hold both components together with adequate holding force and without damaging the boss tower components result in HGA torque retention. Measurements of HSA KPIV after swaging obtained from deformation of base plate and arm pad together. Due to hard disk drive is dynamically developed by increasing in the areal den
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7

Crawford, Julie H., Annette Hughes, Paul K. Cannell, and Richard Herrmann. "Alloimmunisation of Patients Undergoing Bone Marrow Transplantation in the Setting of Leucodepleted Apheresis-Collected Single Donor Platelets." Blood 106, no. 11 (2005): 962. http://dx.doi.org/10.1182/blood.v106.11.962.962.

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Abstract Introduction: Immune platelet transfusion refractoriness often leads to requirements for specialised platelet products. Our patients are screened weekly for the presence of platelet antibodies during bone marrow transplantation (BMT) protocols and are routinely issued leucodepleted (LD) packed red cells and apheresis-collected leucodepleted single donor platelets (LDSDP). Aims: We assessed the alloimmunisation rate in BMT patients, the impact of this on transfusion requirements and addressed the value of continued routine platelet antibody (PAI) screening in the setting of LDSDP. Resu
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8

Bidet, Philippe, Stéphane Bonacorsi, Olivier Clermont, Caroline De Montille, Naima Brahimi, and Edouard Bingen. "Multiple Insertional Events, Restricted by the Genetic Background, Have Led to Acquisition of Pathogenicity Island IIJ96-Like Domains among Escherichia coli Strains of Different Clinical Origins." Infection and Immunity 73, no. 7 (2005): 4081–87. http://dx.doi.org/10.1128/iai.73.7.4081-4087.2005.

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ABSTRACT We investigated the dissemination of pathogenicity island (PAI) IIJ96-like elements (hra, hly, cnf1, and pap) among 455 Escherichia coli isolates from children and adults with urinary tract infection (UTI), neonates with meningitis or colonized healthy neonates, and 74 reference strains by means of PCR phylogenetic grouping, ribotyping, and PCR analysis of virulence genes. Colocalization of these genes was documented by pulsed-field gel electrophoresis followed by Southern hybridization and long-range PCR (LRPCR) between the hra and the papG alleles. Site-specific insertion of the PAI
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9

Bingen-Bidois, Martine, Olivier Clermont, Stéphane Bonacorsi, et al. "Phylogenetic Analysis and Prevalence of Urosepsis Strains of Escherichia coli Bearing Pathogenicity Island-Like Domains." Infection and Immunity 70, no. 6 (2002): 3216–26. http://dx.doi.org/10.1128/iai.70.6.3216-3226.2002.

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ABSTRACT We characterized 100 Escherichia coli urosepsis isolates from adult patients according to host compromise status by means of ribotyping, PCR phylogenetic grouping, and PCR detection of papG alleles and the virulence-related genes sfa/foc, fyuA, irp-2, aer, hly, cnf-1 and hra. We also tested these strains for copies of pap and hly and their direct physical linkage with other virulence genes in an attempt to look for pathogenicity islands (PAIs) described for the archetypal uropathogenic strains J96, CFT073, and 536. Most of the isolates belonged to E. coli phylogenetic groups B2 and D
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10

Schiller, Eik, Ralf Bergmann, Gerd Wunderlich, Michael Andreeff, Anita Jacob, and Hans-Jürgen Pietzsch. "Ga-68- and Cu-64-Labeled NOTA-Albumin Conjugates for PET Sentinel Lymph Node Imaging." ISRN Molecular Imaging 2013 (February 18, 2013): 1–8. http://dx.doi.org/10.1155/2013/386976.

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Our objective was to develop and evaluate Ga-68- and Cu-64-labeled albumin conjugates for PET imaging of sentinel lymph nodes. Four different albumin conjugates were prepared starting from NOTA-HSA. The lymph node uptake of Ga-68- and Cu-64-labeled albumin conjugates was investigated after subcutaneous injection into the foot pad of Wistar rats. A pig model was utilized for further biological evaluation of the lymph node uptake. For all the four conjugates, radiolabeling with Ga-68 and Cu-64 resulted in >95% radiochemical yield. Denatured and mannosylated Ga-68 NOTA-HSA revealed the highest
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Kim, Jung-Gun, Byoung Keun Park, Chang-Hyuk Yoo, Eunkyung Jeon, Jonghee Oh, and Ingyu Hwang. "Characterization of the Xanthomonas axonopodis pv. glycines Hrp Pathogenicity Island." Journal of Bacteriology 185, no. 10 (2003): 3155–66. http://dx.doi.org/10.1128/jb.185.10.3155-3166.2003.

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ABSTRACT We sequenced an approximately 29-kb region from Xanthomonas axonopodis pv. glycines that contained the Hrp type III secretion system, and we characterized the genes in this region by Tn3-gus mutagenesis and gene expression analyses. From the region, hrp (hypersensitive response and pathogenicity) and hrc (hrp and conserved) genes, which encode type III secretion systems, and hpa (hrp-associated) genes were identified. The characteristics of the region, such as the presence of many virulence genes, low G+C content, and bordering tRNA genes, satisfied the criteria for a pathogenicity is
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12

Gulmira Zharmakhanova, Gulmira Zharmakhanova, Victoria Kononetc Victoria Kononetc, Lyazzat Syrlybayeva Lyazzat Syrlybayeva, Eleonora Nurbaulina Eleonora Nurbaulina, and Lyazzat Baikadamova Lyazzat Baikadamova. "HYPERPHENYLALANINEMIA: CASE REPORT." Ambiance in Life International Scientific Journal in Medicine of Southern Caucasus 06, no. 01 (2021): 96–97. http://dx.doi.org/10.36962/0601202196.

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Background: Hyperphenylalaninemia (HPA) is a group of autosomal recessive diseases caused by impaired metabolism of the essential amino acid phenylalanine (Phe), which enters the human body with protein food [1]. HFA combines several genetically heterogeneous forms of phenylalanine metabolism disorders similar in clinical features: classical phenylketonuria (PKU), caused by phenylalanine-4-hydroxylase (PAH) deficiency and hyperphenylalaninemia (HPA), associated with tetrahydrobiopterin (BH4) metabolic disorders [2]. The pterin-dependent form of hyperphenylalaninemia accounts for about 2% of al
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13

Nagae, Kenichi, Yasufumi Asao, Yoshiaki Sudo, et al. "Real-time 3D Photoacoustic Visualization System with a Wide Field of View for Imaging Human Limbs." F1000Research 7 (November 19, 2018): 1813. http://dx.doi.org/10.12688/f1000research.16743.1.

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Background: A breast-specific photoacoustic imaging (PAI) system prototype equipped with a hemispherical detector array (HDA) has been reported as a promising system configuration for providing high morphological reproducibility for vascular structures in living bodies. Methods: To image the vasculature of human limbs, a newly designed PAI system prototype (PAI-05) with an HDA with a higher density sensor arrangement was developed. The basic device configuration mimicked that of a previously reported breast-specific PAI system. A new imaging table and a holding tray for imaging a subject's lim
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14

Nagae, Kenichi, Yasufumi Asao, Yoshiaki Sudo, et al. "Real-time 3D Photoacoustic Visualization System with a Wide Field of View for Imaging Human Limbs." F1000Research 7 (February 7, 2019): 1813. http://dx.doi.org/10.12688/f1000research.16743.2.

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Background: A breast-specific photoacoustic imaging (PAI) system prototype equipped with a hemispherical detector array (HDA) has been reported as a promising system configuration for providing high morphological reproducibility for vascular structures in living bodies. Methods: To image the vasculature of human limbs, a newly designed PAI system prototype (PAI-05) with an HDA with a higher density sensor arrangement was developed. The basic device configuration mimicked that of a previously reported breast-specific PAI system. A new imaging table and a holding tray for imaging a subject's lim
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15

Li, Guangyuan, Coleman H. Young, Bryce Snow, et al. "Identification and Characterization of the Lactating Mouse Mammary Gland Citrullinome." International Journal of Molecular Sciences 21, no. 7 (2020): 2634. http://dx.doi.org/10.3390/ijms21072634.

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Citrullination is a post-translational modification (PTM) in which positively charged peptidyl-arginine is converted into neutral peptidyl-citrulline by peptidylarginine deiminase (PAD or PADI) enzymes. The full protein citrullinome in many tissues is unknown. Herein, we used mass spectrometry and identified 107 citrullinated proteins in the lactation day 9 (L9) mouse mammary gland including histone H2A, α-tubulin, and β-casein. Given the importance of prolactin to lactation, we next tested if it stimulates PAD-catalyzed citrullination using mouse mammary epithelial CID-9 cells. Stimulation of
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16

Sajan, Alen, Akash Mandhan, Beatrice Wong, Smita Abraham, and Simona Stefan. "ODP436 Adrenal Insufficiency After Combined Treatment of Itraconazole and Triamcinolone." Journal of the Endocrine Society 6, Supplement_1 (2022): A73. http://dx.doi.org/10.1210/jendso/bvac150.151.

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Abstract Introduction Adrenal insufficiency (AI) has been reported due to the use of budesonide and itraconazole. We report an unusual presentation of adrenal insufficiency from the use of triamcinolone and itraconazole. Clinical Case 46-year-old man with a history of NASH and alcoholic cirrhosis requiring liver transplant presented to ER with two weeks of progressive lower extremity weakness. He reported difficulty climbing stairs and getting up from a chair. He denied anorexia, nausea, vomiting, abdominal pain, or lightheadedness. He was treated with itraconazole for diffuse histoplasmosis f
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17

Çatıker, Efkan, and Temel Öztürk. "Alifatik Ester-Eter Yapılı Yeni Makromonomerlerin Sentezi ve “Dolaylı Aşılama” Stratejisinde Kullanımı." Karadeniz Fen Bilimleri Dergisi 14, no. 3 (2024): 1471–85. http://dx.doi.org/10.31466/kfbd.1475630.

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Bu çalışmada, poli(akrilik asit-g-hidroksietil akrilat) (PAA-g-PHEA) ve poli(akrilik asit-g-hidroksipropil akrilat) (PAA-g-PHPA) aşı kopolimerlerinin serbest radikal polimerizasyonu (SRP) yöntemiyle sentezleri gerçekleştirildi. Bunun için ilk aşamada, 2-hidroksietil akrilat (HEA) ve 2-hidroksipropil akrilat (HPA) kullanılarak baz katalizli hidrojen transfer polimerizasyonu (HTP) metoduyla sırasıyla poli(2-hidroksietil akrilat) (PHEA) ve poli(2-hidroksipropil akrilat) (PHPA) elde edildi. Elde edilen bu yapılar zincir uçlarında vinil grupları barındırdığından ikinci aşamada makromonomer olarak k
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18

Zhu, Tengjiao, Xing Xin, Bin Yang, et al. "Association Between Clinical Symptoms and Radiographic Features in Late-Stage Knee Osteoarthritis Using a New Radiographic Parameter." Pain Medicine 22, no. 7 (2021): 1539–47. http://dx.doi.org/10.1093/pm/pnab029.

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Abstract Objective In this study, we proposed a new radiographic parameter, the plateau attrition index (PAI), and the PAI grades (PAIs) to explore the relationship between subchondral attrition of the tibial plateau and symptoms of knee osteoarthritis (OA) in patients with late-stage knee osteoarthritis. Method One hundred nineteen patients with late-stage knee osteoarthritis were enrolled. The Kellgren and Lawrence (K/L) grades and hip-knee-ankle (HKA) angle were used to characterize the radiographic features of knee OA. The bone attrition of the tibial plateau was determined by the PAI and
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Barone, B., J. Dantas, M. Almeida, et al. "Pancreatic Autoantibodies, HLA DR and PTPN22 Polymorphisms in First Degree Relatives of Patients with Type 1 Diabetes and Multiethnic Background." Experimental and Clinical Endocrinology & Diabetes 119, no. 10 (2011): 618–20. http://dx.doi.org/10.1055/s-0031-1280799.

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AbstractTo evaluate the prevalence of pancreatic auto-antibodies (PAb) as well as its relationship with HLA DR B1 and PTPN22 polymorphisms in first degree relatives (FDR) of Brazilian patients with Type 1 diabetes (T1D) and multiethnic background.FDR of patients with T1D were interviewed and blood was sampled for PAb measurement, HLA DRB1 and PTPN22 genotyping. Genotyping was also performed in index cases.In FDR (n=78), 16.7% presented at least one PAb. These individuals had a higher prevalence of HLA DRB1* 03 than others (p=0.03), without differences in PTPN22 genotyping. While the genetic pr
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Vakili, Mohammadtaghi, Haider M. Zwain, Amin Mojiri, et al. "Effective Adsorption of Reactive Black 5 onto Hybrid Hexadecylamine Impregnated Chitosan-Powdered Activated Carbon Beads." Water 12, no. 8 (2020): 2242. http://dx.doi.org/10.3390/w12082242.

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In this study, hexadecylamine (HDA) impregnated chitosan-powder activated carbon (Ct-PAC) composite beads were successfully prepared and applied to adsorption of the anionic dye reactive black 5 (RB5) in aqueous solution. The Ct-PAC-HDA beads synthesized with 0.2 g powdered activated carbon (PAC) and 0.04 g HDA showed the highest dye removal efficiency. The prepared beads were characterized using Fourier-transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). Various adsorption parameters, i.e., adsorbent dosage, pH, and contact time, which affect the adsorption performa
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Knutsen, Alan P., Barbara Kariuki, Luis A. Santiago, et al. "HLA-DR, IL-4RA, and IL-10: Genetic Risk Factors in Allergic Bronchopulmonary Aspergillosis." Pediatric Asthma, Allergy & Immunology 21, no. 4 (2008): 185–90. http://dx.doi.org/10.1089/pai.2008.0505.

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Saputro, Eko, Djalal Rosidi, Lilik Eka Radiati, and Warsito Warsito. "KAJIAN PUSTAKA: PEMICU KANKER DALAM SATE, AYAM/BEBEK/IKAN BAKAR/GORENG DAN ABON." Jurnal Litbang Sukowati : Media Penelitian dan Pengembangan 4, no. 2 (2021): 60–78. http://dx.doi.org/10.32630/sukowati.v4i2.187.

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Masyarakat Indonesia sangat gemar mengonsumsi sate, ayam/ bebek/ ikan bakar atau goreng karena sangat nikmat tetapi konsumen masih belum mengerti bahwa ada konsekuensi karsinogen heterocyclic aromatic amines (HAA) dan polycyclic aromatic hydrocarbons (PAH) yang berbahaya bagi kesehatan. Makalah ini bertujuan untuk mengupas tuntas HAA, PAH dan berbagai cara yang telah berhasil meminimalkan kadar mereka agar konsumen tetap dapat menikmati pangan tersebut dengan aman dan nyaman. Pemanasan daging adalah proses wajib untuk memastikan keamanan mikrobiologis, menghilangkan faktor antinutrisional, men
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23

Ryan, Máirín, Patrick S. Moran, Patricia Harrington, et al. "CONTRIBUTION OF STAKEHOLDER ENGAGEMENT TO THE IMPACT OF A HEALTH TECHNOLOGY ASSESSMENT: AN IRISH CASE STUDY." International Journal of Technology Assessment in Health Care 33, no. 4 (2017): 424–29. http://dx.doi.org/10.1017/s026646231700085x.

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Objectives: The aim of this study was to illustrate the contribution of stakeholder engagement to the impact of health technology assessment (HTA) using an Irish HTA of a national public access defibrillation (PAD) program.Background: In response to draft legislation that proposed a PAD program, the Minister for Health requested that Health Information and Quality Authority undertake an HTA to inform the design and implementation of a national PAD program and the necessary underpinning legislation. The draft legislation outlined a program requiring widespread installation and maintenance of au
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Erlandsen, Heidi, Marianne G. Patch, Alejandra Gamez, Mary Straub, and Raymond C. Stevens. "Structural Studies on Phenylalanine Hydroxylase and Implications Toward Understanding and Treating Phenylketonuria." Pediatrics 112, Supplement_4 (2003): 1557–65. http://dx.doi.org/10.1542/peds.112.s4.1557.

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Mutations in the gene encoding for phenylalanine hydroxylase (PAH) result in phenylketonuria (PKU) or hyperphenylalaninemia (HPA). Several 3-dimensional structures of truncated forms of PAH have been determined in our laboratory and by others, using x-ray crystallographic techniques. These structures have allowed for a detailed mapping of the >250 missense mutations known to cause PKU or HPA found throughout the 3 domains of PAH. This structural information has helped formulate rules that might aid in predicting the likely effects of unclassified or newly discovered PAH mutations. Also,
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Abbas, F., JK Clayton, KM Marshall, and J. Senior. "Characterisation of kinin receptors on the human isolated umbilical artery." Journal of Endocrinology 156, no. 2 (1998): 389–94. http://dx.doi.org/10.1677/joe.0.1560389.

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The aim of this study was to determine the kinin responses on human umbilical artery (HUA) and to characterise the kinin receptors present on this tissue. The HUA was found to constrict in response to both the B2 receptor agonist, bradykinin (BK), and the B1 receptor agonist, des-Arg9-BK. The presence of indomethacin (2.79 microM) was found to have no significant effect on the responses to BK and des-Arg9-BK. The presence of the B2 receptor antagonist, HOE-140 (+2.79 microM indomethacin), resulted in a concentration-related rightward displacement of the concentration-effect curves to BK. The a
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Bakhireva, Ludmila N., Elizabeth Solomon, Melissa H. Roberts, et al. "Independent and Combined Effects of Prenatal Alcohol Exposure and Prenatal Stress on Fetal HPA Axis Development." International Journal of Molecular Sciences 25, no. 5 (2024): 2690. http://dx.doi.org/10.3390/ijms25052690.

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Prenatal alcohol exposure (PAE) and prenatal stress (PS) are highly prevalent conditions known to affect fetal programming of the hypothalamic-pituitary-adrenal (HPA) axis. The objectives of this study were to assess the effect of light PAE, PS, and PAE-PS interaction on fetal HPA axis activity assessed via placental and umbilical cord blood biomarkers. Participants of the ENRICH-2 cohort were recruited during the second trimester and classified into the PAE and unexposed control groups. PS was assessed by the Perceived Stress Scale. Placental tissue was collected promptly after delivery; gene
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Yang, Zhi, Fang Liu, and Zhu-lin Yang. "BRMS1 and HPA as Progression, Clinical Biological Behaviors, and Poor Prognosis–related Biomarkers for Gallbladder Adenocarcinoma." Applied Immunohistochemistry & Molecular Morphology 24, no. 4 (2016): 275–82. http://dx.doi.org/10.1097/pai.0000000000000183.

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Sutari, Sutari, V. Yulianti S., Triningsih Triningsih, et al. "OPTIMASI PEMBUATAN COATED TUBE HUMAN SERUM ALBUMIN (HSA) UNTUK KIT RADIOIMMUNOASSAY (RIA) MIKROALBUMINURIA." Jurnal Forum Nuklir 8, no. 1 (2014): 20. http://dx.doi.org/10.17146/jfn.2014.8.1.3476.

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OPTIMASI PEMBUATAN COATED TUBE HUMAN SERUM ALBUMIN (HSA) UNTUK KIT RADIOIMMUNOASSAY (RIA) MIKROAMBUMIN. Radioimmunoassay (RIA) adalah suatu metoda analisis berdasarkan pada reaksi imunologi yakni ikatan antigen-antibodi, metoda ini sangat spesifik dan peka digunakan untuk menentukan kadar zat-zat yang ada di dalam cairan tubuh seperti serum, urine dan lainnya sehingga dapat digunakan untuk mengevaluasi suatu penyakit metabolik seperti diabetes melitus. Penelitian dan pengembangan teknologi Kit RIA mikroalbuminuria dengan metode coated tube dilakukan melalui beberapa tahap yakni optimasi pembua
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Vasina, L. V., V. F. Mitreikin, and N. N. Petrishchev. "Endothelial hemostatic properties in diffuse toxic goiter." Problems of Endocrinology 49, no. 5 (2003): 39–41. http://dx.doi.org/10.14341/probl11756.

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Changes in endothelial functional activity and lesion were studied in 38patients with diffuse toxic goiter (DTG) in the presence of thyrotoxicosis. There was an increase in CD4/CD8 ratios and the count of cells carrying CD+ and HLA-DRA. The blood levels of tumor necrosis factor-a (TNF-a) and IL-8 were also significantly higher in thyrotoxicosis than those at remission. There was a significant correlation between the blood levels of thyroid hormones and the higher blood concentration of PAI-1 and a negative correlation with the content of PAI-1, which is indicative of an increase in the blood f
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Vela-Amieva, Marcela, Miguel Angel Alcántara-Ortigoza, Ariadna González-del Angel, et al. "In Silico Structural Protein Evaluation of the Phenylalanine Hydroxylase p.(Tyr77His) Variant Associated with Benign Hyperphenylalaninemia as Identified through Mexican Newborn Screening." Children 10, no. 12 (2023): 1865. http://dx.doi.org/10.3390/children10121865.

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Hyperphenylalaninemia (HPA), which includes phenylketonuria (PKU), is a genetic autosomal recessive disorder arising from a deficiency in the enzyme named phenylalanine hydroxylase (PAH). Affected patients can experience severe and irreversible neurological impairments when phenylalanine (Phe) blood concentration exceeds 360 μmol/L (6 mg/dL). Here, we describe a female HPA patient who was born in Mexico to Cuban non-consanguineous parents and identified by newborn screening, and who bears the previously unreported PAH NM_000277.3(PAH):c.[229T>C];[1222C>T] or p.[Tyr77His];[Arg408Trp] geno
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Kozachik, Sharon L., and Gayle G. Page. "A Hyperresponsive HPA Axis May Confer Resilience Against Persistent Paclitaxel-Induced Mechanical Hypersensitivity." Biological Research For Nursing 18, no. 3 (2015): 290–98. http://dx.doi.org/10.1177/1099800415609418.

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Paclitaxel (PAC) treatment is associated with persistent, debilitating neuropathic pain that affects the hands and feet. Female sex and biological stress responsivity are risk factors for persistent pain, but it is unclear whether these important biologically based factors confer risk for PAC-induced neuropathic pain. To determine the relative contributions of sex and hypothalamic–pituitary–adrenal (HPA)-axis stress responsivity to PAC-induced mechanical hypersensitivity, we employed a PAC protocol consisting of three, 2-week cycles of every-other-day doses of PAC 1 mg/kg versus saline (Week 1
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Andrade, Fernando, Ainara Cano, María Unceta Suarez, et al. "Urine Phenylacetylglutamine Determination in Patients with Hyperphenylalaninemia." Journal of Clinical Medicine 10, no. 16 (2021): 3674. http://dx.doi.org/10.3390/jcm10163674.

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Phenylketonuria (PKU), an autosomal-recessive inborn error of phenylalanine (Phe) metabolism is the most prevalent disorder of amino acid metabolism. Currently, clinical follow-up relies on frequent monitoring of Phe levels in blood. We hypothesize that the urine level of phenylacetylglutamine (PAG), a phenyl-group marker, could be used as a non-invasive biomarker. In this cross-sectional study, a validated liquid chromatography coupled to tandem mass spectrometry (LC-MS) method was used for urinary PAG quantification in 35 participants with hyperphenylalaninemia (HPA) and 33 age- and sex-matc
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Walkowiak, Jacek, Michael Gradzielski, Stefan Zauscher, and Matthias Ballauff. "Interaction of Proteins with a Planar Poly(acrylic acid) Brush: Analysis by Quartz Crystal Microbalance with Dissipation Monitoring (QCM-D)." Polymers 13, no. 1 (2020): 122. http://dx.doi.org/10.3390/polym13010122.

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We describe the preparation of a poly(acrylic acid) (PAA) brush, polymerized by atom transfer radical polymerization (ATRP) of tert-butyl acrylate (tBA) and subsequent acid hydrolysis, on the flat gold surfaces of quartz-crystal microbalance (QCM) crystals. The PAA brushes were characterized by Fourier transform infrared (FT-IR) spectroscopy, ellipsometry and water contact angle analysis. The interaction of the PAA brushes with human serum albumin (HSA) was studied for a range of ionic strengths and pH conditions by quartz-crystal microbalance with dissipation monitoring (QCM-D). The quantitat
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Dalvi, Sonal, Carla Nicholson, Fares Najar, et al. "Arhodomonas sp. Strain Seminole and Its Genetic Potential To Degrade Aromatic Compounds under High-Salinity Conditions." Applied and Environmental Microbiology 80, no. 21 (2014): 6664–76. http://dx.doi.org/10.1128/aem.01509-14.

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ABSTRACTArhodomonassp. strain Seminole was isolated from a crude oil-impacted brine soil and shown to degrade benzene, toluene, phenol, 4-hydroxybenzoic acid (4-HBA), protocatechuic acid (PCA), and phenylacetic acid (PAA) as the sole sources of carbon at high salinity. Seminole is a member of the genusArhodomonasin the classGammaproteobacteria, sharing 96% 16S rRNA gene sequence similarity withArhodomonas aquaeoleiHA-1. Analysis of the genome predicted a number of catabolic genes for the metabolism of benzene, toluene, 4-HBA, and PAA. The predicted pathways were corroborated by identification
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35

Sliwowska, J. H. "FC29-02 - Is prenatal exposure to alcohol a factor which re-program the brain?" European Psychiatry 26, S2 (2011): 1978. http://dx.doi.org/10.1016/s0924-9338(11)73681-1.

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IntroductionFetal programming refers to the concept that early environmental factors, including prenatal exposure to stress and drugs, can permanently organize or imprint physiological and behavioural systems and increase vulnerability to disorders such as depression and anxiety later in life.AimsIs prenatal exposure to alcohol a factor which re-programs the brain?ObjectivesEffects of prenatal alcohol exposure (PAE) on:1)the hypothalamus-pituitary-adrenal (HPA) axis;2)the hypothalamus-pituitary-gonadal (HPG) axis;3)serotonergic (5-HT) system and4)adult hippocampal neurogenesis are presented.Me
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Babiak, Emil, Samuel Vysocanský, Milan Luknár, et al. "LOWER MIR-126 PLASMA CONCENTRATIONS IN HUMAN PULMONARY ARTERIAL HYPERTENSION." Journal of Hypertension 42, Suppl 1 (2024): e176. http://dx.doi.org/10.1097/01.hjh.0001021172.78748.1e.

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Objective: Pulmonary arterial hypertension (PAH) is a fatal incurable disease with complicated and lengthy diagnosis. However, its early detection is a prerequisite for better treatment and longer survival of patients. Therefore, the goal is not only to find new treatment procedures, but also ways to diagnose PAH faster and easier by biomarkers specifically involved in disease progression. Tissues of the cardiovascular system produce, among others, hsa-mir-126-3p (endothelium) and hsa-mir-423-5p (cardiac muscle). These microRNAs are specific for these tissues and therefore we expect a change i
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Malcolm, D. "Serum fructosamine and HbA." Practical Diabetes International 6, no. 5 (1989): 239. http://dx.doi.org/10.1002/pdi.1960060515.

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Merzougui, Charaf-Eddine, Pierre Aimar, Patrice Bacchin, and Christel Causserand. "pH-Dependent Adsorption of Human Serum Albumin Protein on a Polystyrene-Block–Poly(acrylic acid)-Coated PVDF Membrane." Membranes 13, no. 12 (2023): 886. http://dx.doi.org/10.3390/membranes13120886.

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This study reports the investigation of human serum albumin (HSA) adsorption on a poy-styrene-block–poly(acrylic acid) (PS-b-PAA)-coated PVDF membrane, which is a potential smart material for biomedical applications. First, copolymer coating on the membrane surface was successfully performed, due to the hydrophobic interaction of the PS anchoring group with the PVDF membrane. This was confirmed by Fourier transform infrared spectroscopy (FTIR) characterization of the membrane. Then, HSA adsorption onto the coated membrane was assessed and was proved to be strongly dependent on the pH of the pr
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Asih, Pribadi, Nicky Sealandhi Irnanda, Thomas Amrata Fitrah, and Risqi Wahyu Jati Utama. "Perencanaan Pelapisan Ulang Dengan Perkerasan Lentur Pada Turn Pad Bandar Udara Internasional Husein Sastranegara Bandung." SKYHAWK : Jurnal Aviasi Indonesia 4, no. 1 (2024): 319–30. https://doi.org/10.52074/skyhawk.v4i1.230.

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Dalam penelitian ini, digunakan data pergerakan pesawat udara dari Bandar Udara Internasional Husein Sastranegara Bandung. Sehingga dapat di rencanakan tebal perkerasan lentur untuk overlay turn pad. Perencanaan tebal perkerasan menggunakan metode perhitungan dari software FAARFIELD dan dianalisan ACN-PCN menggunakan software COMFAA. Kesimpulannya kondisi turn pad saat ini memiliki elevasi yang berbeda dengan badan runway, karena pada saat pekerjaan overlay runway yang pada tahun 2017 tidak termasuk dengan overlay turn pad sehingga memiliki ketinggian yang berbeda, maka harus dilakukannya over
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Resa Anzela and Umar Rosadi. "Pengaruh Penggunaan Media Audio Visual Terhadap Perilaku Belajar Siswa Pada Mata Pelajajaran PAI." Journal of Teacher Training and Educational Research 1, no. 1 (2024): 01–08. https://doi.org/10.71280/jotter.v1i1.47.

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The purpose of this study was to determine whether there is an influence of the use of audio-visual media on student learning behavior in PAI subjects. This study used a quantitative approach descriptive method, data collection techniques using questionnaires and observation. instrument Analysis (data validity and data reliability), Classical Assumption Test, namely: Data Normality Test, Data Linearity Test, Hesterokedasticity Test. And Statistical Analysis i.e. Simple Linear Regression Analysis, Correlation Coefficient Analysis, Descriptive Statistical Analysis and t-Test Hypothesis Testing.
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Vela-Amieva, Marcela, Miguel Angel Alcántara-Ortigoza, Isabel Ibarra-González, et al. "An Updated PAH Mutational Spectrum of Phenylketonuria in Mexican Patients Attending a Single Center: Biochemical, Clinical-Genotyping Correlations." Genes 12, no. 11 (2021): 1676. http://dx.doi.org/10.3390/genes12111676.

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Establishing the genotypes of patients with hyperphenylalaninemia (HPA)/phenylketonuria (PKU, MIM#261600) has been considered a cornerstone for rational medical management. However, knowledge of the phenylalanine hydroxylase gene (PAH) mutational spectrum in Latin American populations is still limited. Herein, we aim to update the mutational PAH spectrum in the largest cohort of HPA/PKU Mexican patients (N = 124) reported to date. The biallelic PAH genotype was investigated by Sanger automated sequencing, and genotypes were correlated with documented biochemical phenotypes and theoretical tetr
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Berrached, Chamssedine, Diane Bouw, Marc Camiade, Kassem El-Akhdar, Denis Barataud, and Guillaume Neveux. "Wideband, high-efficiency, high-power GaN amplifiers, using MIC and quasi-MMIC technologies, in the 1–4 GHz range." International Journal of Microwave and Wireless Technologies 7, no. 1 (2014): 1–12. http://dx.doi.org/10.1017/s1759078714000476.

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In this paper, the designs and experimental performances of wideband (higher than one octave) high-efficiency, high-power amplifiers (HPA) working in the 1–4 GHz range, using the same GaN process, are presented. They are based on the Bode–Fano integrals, which can be applied to a trade-off calculation between bandwidth and efficiency. Firstly, an microwave intregrated circuits (MIC) wideband HPA, externally matched, is presented. It generates a continuous wave (CW) output power (Pout) greater than 40 W, a power gain (GP) higher than 9.2 dB and a corresponding power added efficiency (PAE) (drai
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Tebieva, Inna S., Polina V. Mishakova, Yulia V. Gabisova, et al. "Genetic Landscape and Clinical Features of Hyperphenylalaninemia in North Ossetia-Alania: High Frequency of P281L and P211T Genetic Variants in the PAH Gene." International Journal of Molecular Sciences 25, no. 9 (2024): 4598. http://dx.doi.org/10.3390/ijms25094598.

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This study, conducted in the Republic of North Ossetia-Alania (RNOA), aimed to explore the genetic landscape of hyperphenylalaninemia (HPA) and phenylketonuria (PKU) in the Ossetian population using data from newborn screening (NBS). Through comprehensive molecular genetic analysis of 29 patients with HPA from diverse ethnic backgrounds, two major genetic variants in the PAH gene, P281L and P211T, were identified, constituting 50% of all detected pathogenic alleles in Ossetian patients. Remarkably, these variants exhibited an exceptionally high frequency in the Ossetian population, surpassing
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Pecimonova, Martina, Daniela Kluckova, Frantisek Csicsay, et al. "Structural and Functional Impact of Seven Missense Variants of Phenylalanine Hydroxylase." Genes 10, no. 6 (2019): 459. http://dx.doi.org/10.3390/genes10060459.

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The molecular genetics of well-characterized inherited diseases, such as phenylketonuria (PKU) and hyperphenylalaninemia (HPA) predominantly caused by mutations in the phenylalanine hydroxylase (PAH) gene, is often complicated by the identification of many novel variants, often with no obvious impact on the associated disorder. To date, more than 1100 PAH variants have been identified of which a substantial portion have unknown clinical significance. In this work, we study the functionality of seven yet uncharacterized PAH missense variants p.Asn167Tyr, p.Thr200Asn, p.Asp229Gly, p.Gly239Ala, p
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Wu, Yi, Yuchuan Liu, and Robert Colman. "Mechanisms by which cleaved kininogen inhibits endothelial cell differentiation and signalling." Thrombosis and Haemostasis 104, no. 11 (2010): 875–85. http://dx.doi.org/10.1160/th10-01-0017.

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SummaryWe have shown that cleaved high-molecular-weight kininogen inhibits endoththelial cell tube and vacuole formation in a concentration-dependent manner and this correlates with its recognised anti-angiogenic activity. The antibody against the urokinase plasminogen activator receptor (uPAR) mimicked the inhibitory effect of cleaved kininogen (HKa) on apoptosis (HKa: 30% and uPAR antibody: 26%) and tube formation. In tumour angiogenesis, cancer cells release angiogenic stimulators, such as vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF), thus stimulating
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Zotz, Rainer B., Clara Finger, Andrea Gerhardt, and Rudiger E. Scharf. "Risk Determinants of Nonarteritic Ischemic Optic Neuropathy (NAION)." Blood 112, no. 11 (2008): 5349. http://dx.doi.org/10.1182/blood.v112.11.5349.5349.

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Abstract Background: The aim of our present study was to examine the risk factors for atherosclerosis as well as thrombophilic risk factors for their role in patients with NAION in comparison to healthy controls. Methods: Prospective case-control-design with 109 Patients and 109 age-and sex-matched healthy controls. Results: Elevated levels of fibrinogen, FVIII:C, FIX:C, FXI:C, plasminogen activity, von Willebrand antigen (vWF:Ag) and activity, triglycerides, elevated erythrocyte sedimentation rate and decreased levels of high density lipoprotein (HDL) proved to be significant risk factors ass
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Opu, Susana Tanggu, Elfis Umbu Katongu Retang, and Elsa Christin Saragih. "FAKTOR-FAKTOR YANG MEMPENGARUHI PRODUKSI PADI SAWAH IRIGASI DI DESA LAI HAU KECAMATAN LEWA TIDAHU KABUPATEN SUMBA TIMUR." Agrivet : Jurnal Ilmu-Ilmu Pertanian dan Peternakan (Journal of Agricultural Sciences and Veteriner) 10, no. 1 (2022): 121–30. http://dx.doi.org/10.31949/agrivet.v10i1.2654.

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Penelitian ini bertujuan untuk mengetahui pengaruh luas lahan, tenaga kerja, benih, pupuk urea, pupuk NPK dan pestisida secara simultan maupun parsial terhadap produksi padi sawah di Desa Lai Hau. Penelitian ini dilakukan di Desa Lai Hau Kecamatan Lewa Tidahu Kabupaten Sumba Timur dengan menggunakan data primer dan data sekunder. Pengambilan sampel dalam penelitian ini dilakukan dengan metode sistematic random sampling dengan jumlah responden 81 petani. Penelitian ini menggunakan metode deskriptif kuantitatif dan analisis data regresi linear bernganda. Hasil penelitian ini menunjukan bahwa var
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Ngai, Ying Fai, Dian C. Sulistyoningrum, Ryan O'Neill, Sheila M. Innis, Joanne Weinberg, and Angela M. Devlin. "Prenatal alcohol exposure alters methyl metabolism and programs serotonin transporter and glucocorticoid receptor expression in brain." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 309, no. 5 (2015): R613—R622. http://dx.doi.org/10.1152/ajpregu.00075.2015.

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Prenatal alcohol exposure (PAE) programs the fetal hypothalamic-pituitary-adrenal (HPA) axis, resulting in HPA dysregulation and hyperresponsiveness to stressors in adulthood. Molecular mechanisms mediating these alterations are not fully understood. Disturbances in one-carbon metabolism, a source of methyl donors for epigenetic processes, contributes to alcoholic liver disease. We assessed whether PAE affects one-carbon metabolism (including Mtr, Mat2a, Mthfr, and Cbs mRNA) and programming of HPA function genes ( Nr3c1, Nr3c2, and Slc6a4) in offspring from ethanol-fed (E), pair-fed (PF), and
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Pwee, Keng Ho. "PP69 Prostatic Artery Embolisation For Benign Prostatic Hyperplasia." International Journal of Technology Assessment in Health Care 34, S1 (2018): 94. http://dx.doi.org/10.1017/s0266462318002271.

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Introduction:Prostatic artery embolization (PAE) was introduced in the 1970s to control major bleeding after prostate surgery. The procedure was noticed to improve the lower urinary tract symptoms of benign prostatic hyperplasia (BPH) and in 2010, PAE was first investigated as an alternative treatment for BPH. A rapid health technology assessment (HTA) was carried out to inform our hospital's decision on introducing this procedure.Methods:The rapid HTA investigated the safety and clinical effectiveness of PAE for patients with BPH. The PICO elements were: Population- Patients with symptomatic
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Park, Hyeong-Geun, Van-Son Trinh, Mun-Kyo Lee, Bok-Hyung Lee, Kyoung-Il Na, and Jung-Dong Park. "A 32-GHz Eight-Way Power Amplifier MMIC in 150 nm GaN HEMT Technology." Electronics 12, no. 15 (2023): 3278. http://dx.doi.org/10.3390/electronics12153278.

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This paper presents a 32 GHz high-power amplifier (HPA) with a design strategy to achieve high-power output with reliable operation for Ka-band deep space satellite communication in 150 nm GaN HEMT technology. The presented Ka-band HPA employs a cascaded two-stage common source amplifier topology, and the output stage comprises an eight-way power combining network in the current mode. The interstage matching network is designed with the bandpass configuration utilizing capacitors and transmission lines to provide better stability at the low-frequency regime. The implemented Ka-band HPA achieve
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