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1

Carlson, G. L., M. Saeed, R. A. Little, and M. H. Irving. "Serum leptin concentrations and their relation to metabolic abnormalities in human sepsis." American Journal of Physiology-Endocrinology and Metabolism 276, no. 4 (1999): E658—E662. http://dx.doi.org/10.1152/ajpendo.1999.276.4.e658.

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Circulating leptin concentrations are raised in animal models of inflammation and sepsis. The purpose of this study was to determine the effect of sepsis on serum leptin concentration in humans and to examine the relationship between leptin and the metabolic consequences of sepsis. Resting energy expenditure, insulin sensitivity, and fasting serum leptin, plasma insulin, and cortisol concentrations were measured in 20 subjects with intra-abdominal sepsis and 20 healthy control subjects, before and during a 2-h period of euglycemic hyperinsulinemia. Fasting serum leptin concentrations were simi
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2

Pieracci, F. M., and P. S. Barie. "Management of Severe Sepsis of Abdominal Origin." Scandinavian Journal of Surgery 96, no. 3 (2007): 184–96. http://dx.doi.org/10.1177/145749690709600302.

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Severe sepsis is a life-threatening condition that may occur as a sequela of intra-abdominal infections (IAIs) of all types. Diagnosis of IAIs is predicated upon the combination of physical examination and imaging techniques. Diffuse peritonitis usually requires urgent surgical intervention. In the absence of diffuse peritonitis, abdominal computed tomography remains the most useful test for the diagnosis of IAIs, and is essential to both guide therapeutic interventions and evaluate suspected treatment failure in the critically ill patient. Parameters most consistently associated with poor out
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3

Siegler, Benedikt Hermann, Marc Altvater, Jan Niklas Thon, et al. "Postoperative abdominal sepsis induces selective and persistent changes in CTCF binding within the MHC-II region of human monocytes." PLOS ONE 16, no. 5 (2021): e0250818. http://dx.doi.org/10.1371/journal.pone.0250818.

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Background Postoperative abdominal infections belong to the most common triggers of sepsis and septic shock in intensive care units worldwide. While monocytes play a central role in mediating the initial host response to infections, sepsis-induced immune dysregulation is characterized by a defective antigen presentation to T-cells via loss of Major Histocompatibility Complex Class II DR (HLA-DR) surface expression. Here, we hypothesized a sepsis-induced differential occupancy of the CCCTC-Binding Factor (CTCF), an architectural protein and superordinate regulator of transcription, inside the M
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4

Koca, Uğur, Çimen Gülben Olguner, Bekir Uğur Ergür, et al. "The Effects of Dexmedetomidine on Secondary Acute Lung and Kidney Injuries in the Rat Model of Intra-Abdominal Sepsis." Scientific World Journal 2013 (2013): 1–11. http://dx.doi.org/10.1155/2013/292687.

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In the present study, the effects of dexmedetomidine on secondary lung and kidney injuries were studied in the rat model of intra-abdominal sepsis by immunohistological and biochemical examinations. We measured serum creatinine, kidney tissue malondialdehide and plasma neutrophil gelatinase-associated lipocalin levels. In order to evaluate tissue injury we determined kidney tissue mononuclear cell infiltration score, alveolar macrophage count, histological kidney and lung injury scores and kidney and lung tissue immunoreactivity scores. We demonstrated that dexmedetomidine attenuates sepsis-in
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5

Luo, Lingtao, Su Zhang, Yongzhi Wang, et al. "Proinflammatory role of neutrophil extracellular traps in abdominal sepsis." American Journal of Physiology-Lung Cellular and Molecular Physiology 307, no. 7 (2014): L586—L596. http://dx.doi.org/10.1152/ajplung.00365.2013.

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Excessive neutrophil activation is a major component in septic lung injury. Neutrophil-derived DNA may form extracellular traps in response to bacterial invasions. The aim of the present study was to investigate the potential role of neutrophil extracellular traps (NETs) in septic lung injury. Male C57BL/6 mice were treated with recombinant human (rh)DNAse (5 mg/kg) after cecal ligation and puncture (CLP). Extracellular DNA was stained by Sytox green, and NET formation was quantified by confocal microscopy and cell-free DNA in plasma, peritoneal cavity, and lung. Blood, peritoneal fluid, and l
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6

Zantl, Niko, Annette Uebe, Brigitte Neumann, et al. "Essential Role of Gamma Interferon in Survival of Colon Ascendens Stent Peritonitis, a Novel Murine Model of Abdominal Sepsis." Infection and Immunity 66, no. 5 (1998): 2300–2309. http://dx.doi.org/10.1128/iai.66.5.2300-2309.1998.

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ABSTRACT Despite considerable progress, peritonitis and sepsis remain life-threatening conditions. To improve the understanding of the pathophysiology encountered in sepsis, a new standardized and highly reproducible murine model of abdominal sepsis termed colon ascendens stent peritonitis (CASP) was developed. In CASP, a stent is inserted into the ascending colon, which generates a septic focus. CASP employing a stent of 14-gauge diameter (14G stent) results in a mortality of 100% within 18 to 48 h after surgery. By inserting stents of small diameters, mortality can be exactly controlled. Thu
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7

Leinhardt, D. J., J. Arnold, K. A. Shipley, M. M. Mughal, R. A. Little, and M. H. Irving. "Plasma NE concentrations do not accurately reflect sympathetic nervous system activity in human sepsis." American Journal of Physiology-Endocrinology and Metabolism 265, no. 2 (1993): E284—E288. http://dx.doi.org/10.1152/ajpendo.1993.265.2.e284.

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Plasma norepinephrine concentrations ([NE]) when raised in patients with sepsis are thought to indicate increased activity of the sympathetic nervous system (SNS). However, increased SNS activity may occur without a concomitant rise in plasma [NE]. Measurement of NE kinetics (clearance and spillover) is a more accurate and direct assessment of SNS activity. In the present study plasma [NE] and NE kinetics were measured in six patients with intra-abdominal sepsis (septic) using tritiated NE infused to achieve a plateau plasma concentration. The measurements were repeated in the same patients af
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8

Worth, P. J., S. F. Monaghan, R. K. Thakkar, et al. "Compartmentalized Lymphocyte Response To Abdominal Versus Non-abdominal Sources Of Sepsis In Humans." Journal of Surgical Research 165, no. 2 (2011): 238. http://dx.doi.org/10.1016/j.jss.2010.11.505.

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9

Lehmann, Christian, Maral Aali, Juan Zhou, and Bruce Holbein. "Comparison of Treatment Effects of Different Iron Chelators in Experimental Models of Sepsis." Life 11, no. 1 (2021): 57. http://dx.doi.org/10.3390/life11010057.

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Growing evidence indicates that dysregulated iron metabolism with altered and excess iron availability in some body compartments plays a significant role in the course of infection and sepsis in humans. Given that all bacterial pathogens require iron for growth, that iron withdrawal is a normal component of innate host defenses and that bacterial pathogens have acquired increasing levels of antibiotic resistance, targeting infection and sepsis through use of appropriate iron chelators has potential to provide new therapeutics. We have directly compared the effects of three Food and Drug Admini
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10

O'Connell, Rachel L., Glenn K. Wakam, Ali Siddiqui, et al. "Development of a large animal model of lethal polytrauma and intra-abdominal sepsis with bacteremia." Trauma Surgery & Acute Care Open 6, no. 1 (2021): e000636. http://dx.doi.org/10.1136/tsaco-2020-000636.

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BackgroundTrauma and sepsis are individually two of the leading causes of death worldwide. When combined, the mortality is greater than 50%. Thus, it is imperative to have a reproducible and reliable animal model to study the effects of polytrauma and sepsis and test novel treatment options. Porcine models are more translatable to humans than rodent models due to the similarities in anatomy and physiological response. We embarked on a study to develop a reproducible model of lethal polytrauma and intra-abdominal sepsis, which was lethal, though potentially salvageable with treatment.MethodsOur
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11

Malewicz, N. M., K. Walstein, T. Heine, et al. "Early suppression of peripheral mononuclear blood cells in sepsis in response to stimulation with cytomegalovirus, OKT3, and pokeweed mitogen." Journal of Applied Physiology 127, no. 6 (2019): 1539–47. http://dx.doi.org/10.1152/japplphysiol.00438.2019.

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Critically ill patients are at risk for sepsis, and immunosuppressive mechanisms may prevail. Whether functional tests are helpful to detect immune alterations is largely unknown. Therefore, we tested the hypotheses that reactivity of peripheral blood mononuclear cells (PBMCs) to secrete interferon-γ (IFNγ) following stimulation in vitro is decreased in patients with early sepsis compared with postoperative patients. IFNγ secretion [enzyme-linked immunospot (ELISpot)] in response to stimulation with cytomegalovirus (CMV), pokeweed mitogen (PWM), muromonab-anti-CD3 (OKT3), and human leukocyte a
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12

Diedrich, Stephan, Julia van der Linde, Michael Nielson, et al. "The MRI Sepsis Score: An Innovative Tool for the Evaluation of Septic Peritonitis in Mice Using 7-Tesla Small Animal MRI." European Surgical Research 59, no. 3-4 (2018): 126–42. http://dx.doi.org/10.1159/000490663.

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Background: Magnetic resonance imaging (MRI) techniques are rarely used in the context of abdominal sepsis and in sepsis research. This study investigates the impact of MRI for monitoring septic peritonitis in an animal model (colon ascendens stent-induced peritonitis, CASP). The CASP model closely mimics that of human disease and is highly standardized. The most frequently employed readout parameter in mouse CASP studies is prolonged or decreased rate of survival. Monitoring the progression of peritonitis via MRI could provide a helpful tool in the evaluation of severity. The use of alternati
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13

Murando, Federica, Andrea Peloso, and Lorenzo Cobianchi. "Experimental Abdominal Sepsis: Sticking to an Awkward but Still Useful Translational Model." Mediators of Inflammation 2019 (December 5, 2019): 1–8. http://dx.doi.org/10.1155/2019/8971036.

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Animal models are widely used to replicate human intra-abdominal infections. Different methodologies have been described and proposed in the scientific literature, including injection and surgical models. The aim of this review is to recapitulate the advantages and disadvantages of each method to help choose the most appropriate model for individual experimental purposes.
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14

Young, John S., Sean F. Monaghan, Chun S. Chung, William G. Cioffi, Alfred Ayala, and Daithi S. Heffernan. "Divergent Invariant Natural Killer T-Cell Response to Sepsis of Abdominal vs. Non-Abdominal Origin in Human Beings." Surgical Infections 16, no. 1 (2015): 29–35. http://dx.doi.org/10.1089/sur.2014.057.

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15

SIMMS, H. HANK, та RONALD DʼAMICO. "Intra-abdominal sepsis alters tumor necrosis factor-α and interleukin-1β binding to human neutrophils". Critical Care Medicine 20, № 1 (1992): 11–16. http://dx.doi.org/10.1097/00003246-199201000-00009.

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16

Cirioni, Oscar, Andrea Giacometti, Roberto Ghiselli, et al. "LL-37 Protects Rats against Lethal Sepsis Caused by Gram-Negative Bacteria." Antimicrobial Agents and Chemotherapy 50, no. 5 (2006): 1672–79. http://dx.doi.org/10.1128/aac.50.5.1672-1679.2006.

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ABSTRACT We investigated the efficacy of LL-37, the C-terminal part of the only cathelicidin in humans identified to date (termed human cationic antimicrobial protein), in three experimental rat models of gram-negative sepsis. Adult male Wistar rats (i) were given an intraperitoneal injection of 1 mg Escherichia coli 0111:B4 LPS, (ii) were given 2 × 1010 CFU of Escherichia coli ATCC 25922, or (iii) had intra-abdominal sepsis induced via cecal ligation and puncture. For each model, all animals were randomized to receive intravenously isotonic sodium chloride solution, 1-mg/kg LL-37, 1-mg/kg pol
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17

Yin, Mei, Lei Si, Weidong Qin, et al. "Predictive Value of Serum Albumin Level for the Prognosis of Severe Sepsis Without Exogenous Human Albumin Administration: A Prospective Cohort Study." Journal of Intensive Care Medicine 33, no. 12 (2016): 687–94. http://dx.doi.org/10.1177/0885066616685300.

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Background: The prognostic significance of serum albumin levels in patients with sepsis has previously been reported; however, these studies have not excluded the potential confounding effect of exogenous albumin administration. In this study, we investigate the predictive value of serum albumin for the prognosis of severe sepsis without the interference of exogenous albumin administration. Methods: A prospective cohort study was conducted from April to November 2014 in the internal and surgical intensive care units of a tertiary care hospital. During the study period, due to a supply shortage
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18

Papoff, Paola, Giancarlo Ceccarelli, Gabriella d'Ettorre, et al. "Gut Microbial Translocation in Critically Ill Children and Effects of Supplementation with Pre- and Pro Biotics." International Journal of Microbiology 2012 (2012): 1–8. http://dx.doi.org/10.1155/2012/151393.

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Bacterial translocation as a direct cause of sepsis is an attractive hypothesis that presupposes that in specific situations bacteria cross the intestinal barrier, enter the systemic circulation, and cause a systemic inflammatory response syndrome. Critically ill children are at increased risk for bacterial translocation, particularly in the early postnatal age. Predisposing factors include intestinal obstruction, obstructive jaundice, intra-abdominal hypertension, intestinal ischemia/reperfusion injury and secondary ileus, and immaturity of the intestinal barrier per se. Despite good evidence
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19

Kaye, Sarrah. "Chronic uterine abscess in a Bolivian grey titi monkey (Plecturocebus donacophilus)." Veterinary Record Case Reports 8, no. 3 (2020): e001138. http://dx.doi.org/10.1136/vetreccr-2020-001138.

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An 11-year-old, reproductively active female Bolivian grey titi monkey (Plecturocebus donacophilus) in a zoological institution was presented for abdominal distension without concurrent clinical signs. Physical examination and imaging studies detected a uterine mass. Preoperative bloodwork revealed anaemia and hyperglobulinaemia. Hysterectomy was performed, but the patient died under anaesthesia. Histopathological examination found a chronic uterine abscess with effacement of the uterine wall and generalised inflammation consistent with sepsis. This case documents an uncommon reproductive trac
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20

Yuan, Yujie, Dongsheng Yan, Gang Han, Guosheng Gu, and Jianan Ren. "Complement C3 depletion compromises the outcomes of human abdominal sepsis: a link to the expansion of regulatory T cells." Journal of the American College of Surgeons 217, no. 3 (2013): S46—S47. http://dx.doi.org/10.1016/j.jamcollsurg.2013.07.095.

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21

Stasi, Alessandra, Giuseppe Castellano, Elena Ranieri, et al. "SARS-CoV-2 and Viral Sepsis: Immune Dysfunction and Implications in Kidney Failure." Journal of Clinical Medicine 9, no. 12 (2020): 4057. http://dx.doi.org/10.3390/jcm9124057.

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causal agent of coronavirus disease 2019 (COVID-19), first emerged in Wuhan, China. The clinical manifestations of patients infected with COVID-19 include fever, cough, and dyspnea, up to acute respiratory distress syndrome (ARDS) and acute cardiac injury. Thus, a lot of severe patients had to be admitted to intensive care units (ICU). The pathogenic mechanisms of SARS-CoV-2 infection are mediated by the binding of SARS-CoV-2 spikes to the human angiotensin-converting enzyme 2 (ACE-2) receptor. The overexpression of human ACE-2
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22

Newsome, Courtni T., Estefany Flores, Alfred Ayala, Stephen Gregory та Jonathan S. Reichner. "Improved Antimicrobial Host Defense in Mice following Poly-(1,6)-β-d-Glucopyranosyl-(1,3)-β-d-Glucopyranose Glucan Treatment by a Gender-Dependent Immune Mechanism". Clinical and Vaccine Immunology 18, № 12 (2011): 2043–49. http://dx.doi.org/10.1128/cvi.05202-11.

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ABSTRACTClinical trials with biological modifiers targeting specific inflammatory mediators associated with severe sepsis have shown no or limited survival benefit. The approach taken in studies reported here was to limit the point source of intra-abdominal infection by potentiating innate immune function, thereby lessening the severity of sepsis and improving survival. Soluble beta-glucans, glucose polymers of the fungal cell wall, have been shown to stimulate innate immune host defense in animal and human studies when administered prior to an infectious challenge. We evaluated the effects of
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23

Rabuel, Christophe, Estelle Renaud, David Brealey, et al. "Human Septic Myopathy: Induction of Cyclooxygenase, Heme Oxygenase and Activation of the Ubiquitin Proteolytic Pathway." Anesthesiology 101, no. 3 (2004): 583–90. http://dx.doi.org/10.1097/00000542-200409000-00006.

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Background Skeletal muscle failure and wasting are manifestations of sepsis in humans that leads to serious and prolonged complications. The authors investigated the role of the major proinflammatory and antiinflammatory pathways, namely the inducible isoforms cyclooxygenase (COX-2) and heme oxygenase (HO-1), and the ubiquitin proteolytic pathway in skeletal muscle of septic patients. Methods Protein expression was detected by Western blot techniques. Muscle biopsies were taken from two muscle groups, rectus abdominis and vastus lateralis, of septic and control patients. Results The study show
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24

Tucker, Erik I., Melani Helm, Owen JT McCarty, Sawan Hurst, David Gailani, and Andras Gruber. "Factor XI Inhibitor Antibody Treatment Improves Survival In a Murine Polymicrobial Sepsis Model." Blood 116, no. 21 (2010): 820. http://dx.doi.org/10.1182/blood.v116.21.820.820.

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Abstract Abstract 820 Sepsis results in a systemic inflammatory state that is frequently accompanied by intravascular coagulation and fibrinolysis, resulting in a coagulopathy with thrombotic and hemorrhagic components (disseminated intravascular coagulation– DIC). We have shown that the plasma coagulation protease factor XI (FXI) contributes substantially to experimental thrombus formation in baboons and mice, but does not appear to be essential for hemostasis. These results are supported by studies in human populations that show FXI deficiency confers a decreased risk of thrombotic ischemic
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25

Deng, X., X. Wang, and R. Andersson. "Endothelial barrier resistance in multiple organs after septic and nonseptic challenges in the rat." Journal of Applied Physiology 78, no. 6 (1995): 2052–61. http://dx.doi.org/10.1152/jappl.1995.78.6.2052.

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Local variations in endothelial permeability, hypothesized to play a role in the development of multiple-organ injury, were measured by 125I-labeled human serum albumin flux and leakage index in rats with a variety of challenges. The albumin flux significantly increased in the peritoneum, pancreas, stomach, and liver in acute pancreatitis; in the peritoneum and liver in abdominal sepsis; in the spleen, proximal small intestine, colon, liver, lungs, heart, and muscle in bacteremia; in the kidneys, liver, lungs, heart, brain, and muscle in endotoxemia; and in the peritoneum, proximal small intes
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26

Yuan, Yujie, Dongsheng Yan, Gang Han, Guosheng Gu, and Jianan Ren. "Complement C3 depletion links to the expansion of regulatory T cells and compromises T-cell immunity in human abdominal sepsis: A prospective pilot study." Journal of Critical Care 28, no. 6 (2013): 1032–38. http://dx.doi.org/10.1016/j.jcrc.2013.09.007.

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27

Schietroma, Mario, Federica Piccione, Francesco Carlei, et al. "Peritonitis from Perforated Appendicitis: Stress Response after Laparoscopic or Open Treatment." American Surgeon 78, no. 5 (2012): 582–90. http://dx.doi.org/10.1177/000313481207800541.

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Elevated intra-abdominal pressure during laparoscopy may promote systemic inflammatory response. In patients with generalized peritonitis from perforated appendicitis, we sought to compare acute phase response and immunologic status from laparoscopic and open approach. One hundred and forty-seven consecutive patients underwent appendectomy for perforated appendicitis (73 patients had laparoscopic appendectomy and 74 patients had open appendectomy. Bacteremia, endotoxemia, white blood cells, peripheral lymphocytes subpopulation, human leukocyte antigen-DR (HLA-DR), neutrophil-elastase, interleu
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28

Shrestha, Prakash, Sean E. O’Neil, Barbara S. Taylor, Olaoluwa Bode-Omoleye, and Gregory M. Anstead. "Hemoptysis in the Immunocompromised Patient: Do Not Forget Strongyloidiasis." Tropical Medicine and Infectious Disease 4, no. 1 (2019): 35. http://dx.doi.org/10.3390/tropicalmed4010035.

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Strongyloidiasis, due to infection with the nematode Strongyloides stercoralis, affects millions of people in the tropics and subtropics. Strongyloides has a unique auto-infective lifecycle such that it can persist in the human host for decades. In immunosuppressed patients, especially those on corticosteroids, potentially fatal disseminated strongyloidiasis can occur, often with concurrent secondary infections. Herein, we present two immunocompromised patients with severe strongyloidiasis who presented with pneumonia, hemoptysis, and sepsis. Both patients were immigrants from developing count
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Binti Kamilen, Khalilah Alhuda, and Mohd Yusran Othman. "Intrauterine Intussusception Presenting as Fetal Ascites and Meconium Peritonitis." International Journal of Human and Health Sciences (IJHHS) 5, no. 0-2 (2021): 18. http://dx.doi.org/10.31344/ijhhs.v5i0-2.336.

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Intussusception is a well-known cause of intestinal obstruction in children. Its occurrence in fetus as an intrauterine incidence is extremely rare and poses a diagnostic difficulty. Intrauterine intussusception may result in intestinal atresia once the gangrenous segment resorbed. However, a very late occurrence of intussusception just prior to delivery may present as meconium peritonitis. We are reporting a case of premature baby who was born at 35 weeks gestation via emergency caesarean for breech in labour. Routine scan 4 days prior to the delivery showed evidence of fetal ascites. She was
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Arnold, J., D. Leinhardt, G. Carlson, P. Gray, R. A. Little, and M. H. Irving. "Thermogenic and hormonal responses to amino acid infusion in septic humans." American Journal of Physiology-Endocrinology and Metabolism 263, no. 1 (1992): E129—E135. http://dx.doi.org/10.1152/ajpendo.1992.263.1.e129.

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Metabolic effects of a commercially available amino acid infusate were investigated in five preoperative patients with abdominal sepsis and five healthy subjects. Oxygen consumption (VO2) was measured continuously during the 3-h study, and blood samples were taken regularly for hormone and metabolite analyses. During 1 h of preinfusion measurements, VO2 was 15% higher (P less than 0.05) in the septic patients. Preinfusion plasma cortisol, glucagon, and catecholamines were also significantly elevated in the septic group. The amino acid solution (9 g nitrogen; 950 kJ; 227 kcal) was infused into
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31

Boldingh, Quirine J. J., Fleur E. E. de Vries, and Marja A. Boermeester. "Abdominal sepsis." Current Opinion in Critical Care 23, no. 2 (2017): 159–66. http://dx.doi.org/10.1097/mcc.0000000000000388.

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32

Peetermans, W. E., and M. Hiele. "Abdominal Sepsis." Acta Clinica Belgica 53, no. 4 (1998): 251–54. http://dx.doi.org/10.1080/17843286.1998.11754170.

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33

Nychytailo, M. Yu. "Abdominal sepsis." Infusion & Chemotherapy, no. 3.2 (December 15, 2020): 231–33. http://dx.doi.org/10.32902/2663-0338-2020-3.2-231-233.

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Background. Sepsis is a life-threatening acute organ dysfunction that occurs as a result of dysregulation of the macroorganism’s response to infection. Septic shock is a variant of sepsis characterized by the circulatory failure, manifested by hypotension and increased lactate levels >2 mmol/L despite adequate infusion, which requires the administration of vasopressors to maintain average blood pressure >65 mm Hg.
 Objective. To describe the management of patients with abdominal sepsis.
 Materials and methods. Analysis of literature data on this topic.
 Results and discuss
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34

Rajput, Ibrahim, Peter Lodge, and Geoffrey I. Sandle. "Mo1959 Basolateral IKCA Channel Inhibition by Octreotide Prevents the Increase in Mucosal Permeability Induced by Chemical Hypoxia in Human Colon: Implications for Preventing Sepsis After Major Abdominal Surgery." Gastroenterology 146, no. 5 (2014): S—702. http://dx.doi.org/10.1016/s0016-5085(14)62549-x.

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35

Jacobson, Richard A., Kiedo Wienholts, Ashley J. Williamson, et al. "Enterococcus faecalis exploits the human fibrinolytic system to drive excess collagenolysis: implications in gut healing and identification of druggable targets." American Journal of Physiology-Gastrointestinal and Liver Physiology 318, no. 1 (2020): G1—G9. http://dx.doi.org/10.1152/ajpgi.00236.2019.

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Perforations, anastomotic leak, and subsequent intra-abdominal sepsis are among the most common and feared complications of invasive interventions in the colon and remaining intestinal tract. During physiological healing, tissue protease activity is finely orchestrated to maintain the strength and integrity of the submucosa collagen layer in the wound. We (Shogan, BD et al. Sci Trans Med 7: 286ra68, 2015.) have previously demonstrated in both mice and humans that the commensal microbe Enterococcus faecalis selectively colonizes wounded colonic tissues and disrupts the healing process by amplif
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Nikiforov, Ivan, John Goldman, Pramil Cheriyath, Anix Vyas, and Vinod Nookala. "Aeromonas hydrophilaSepsis Associated with Consumption of Raw Oysters." Case Reports in Infectious Diseases 2014 (2014): 1–3. http://dx.doi.org/10.1155/2014/163040.

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Introduction. Aeromonas hydrophilais a gram negative bacillus that is native to aquatic environments that is increasingly reported in humans. This case is remarkable forA. hydrophilawith an initial presentation of acute pancreatitis.Case Presentation.A 61-year-old male presented to the emergency department with nausea, vomiting, and abdominal pain for two days. His past medical history was significant for alcohol abuse. Initial laboratory examination showed an elevated white blood cell count, elevated lipase, and elevated liver function tests (LFT). Computer tomography (CT) showed peripancreat
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37

Bartlett, John G. "Intra-abdominal sepsis." Medical Clinics of North America 79, no. 3 (1995): 599–617. http://dx.doi.org/10.1016/s0025-7125(16)30059-1.

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38

Loganathan, Arun. "Intra-abdominal sepsis." Surgery (Oxford) 33, no. 11 (2015): 553–58. http://dx.doi.org/10.1016/j.mpsur.2015.08.007.

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39

Russell, R. C. G. "Intra-Abdominal Sepsis." Journal of the Royal Society of Medicine 80, no. 8 (1987): 471–72. http://dx.doi.org/10.1177/014107688708000801.

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40

Bretland, P. M. "Intra-Abdominal Sepsis." Journal of the Royal Society of Medicine 80, no. 8 (1987): 528–30. http://dx.doi.org/10.1177/014107688708000823.

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Foitzik, Thomas, and Norbert Runkel. "Intra-abdominal sepsis." Current Opinion in Infectious Diseases 9, no. 5 (1996): 353–58. http://dx.doi.org/10.1097/00001432-199610000-00012.

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42

Krukowski, Z. H. "Postoperative abdominal sepsis." British Journal of Surgery 75, no. 12 (1988): 1153–54. http://dx.doi.org/10.1002/bjs.1800751202.

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43

Leaper, D. J., M. Irving, J. Bancewicz, and M. Mughal. "Server abdominal sepsis." British Journal of Surgery 73, no. 8 (1986): 682–83. http://dx.doi.org/10.1002/bjs.1800730839.

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44

Pendela, Venkata Satish, Anisleidys Munoz, JulieAnn Warner, and Roopa Yarlagadda. "Case Report: Germ cell tumor presenting as cecal mass." F1000Research 8 (October 10, 2019): 1737. http://dx.doi.org/10.12688/f1000research.20774.1.

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Extra gonadal germ cell tumors most frequently occur in the anterior mediastinum, retro-peritoneum, and pineal and suprasellar regions. The infrequency of its occurrence inside gastrointestinal tract makes it an arduous diagnostic challenge. A 23 year old male with no significant past medical history presented to the emergency department with increasing abdominal pain, diarrhea, episodic vomiting for 3 weeks. Review of systems was positive for melena and shortness of breath on exertion. Fullness and irregularity along with tenderness was noted around the right iliac region. CT scan (computed t
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Kim, Janice, Hilary Rosen, Kristen Angel, et al. "Transmission of Listeriosis in a Neonatal Intensive Care Unit Supported by Whole-Genome Sequencing." Infection Control & Hospital Epidemiology 41, S1 (2020): s53. http://dx.doi.org/10.1017/ice.2020.536.

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Background: Listeriosis is a rare but serious infectious disease caused by Listeria monocytogenes (LM) and predominantly transmitted through contaminated food. Moreover, 15% of listeriosis cases in the United States are pregnancy associated; nosocomial neonatal transmission in hospitals is extremely rare. In July 2018, the California Department of Public Health (CDPH) was notified of 4 patients, a mother–neonate pair and twin neonates, with listeriosis at the same hospital. The CDPH and San Diego County Health and Human Services Agency initiated an investigation to determine transmission and p
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Flax, Sherri. "ADAMTS13 Immunohistochemical Expression in Normal and Diseased Equine Tissues." Blood 134, Supplement_1 (2019): 4925. http://dx.doi.org/10.1182/blood-2019-127407.

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ADAMTS13 is a metallopeptidase primarily synthesized in the liver. Its main function is to cleave von Willebrand factor (VWF) on the endothelial surface, and thus regulate platelet adhesion at the sites of vascular injury; VWF acts as a scaffold at the site of injury for platelet activation, platelet binding, and clot formation. Platelet activation also results in the release of platelet-dense granule components (such as cytokines, pro- and anti-inflammatory factors and other bioactive molecules) that are essential regulators of coagulation, but are also associated with inflammation. Reduced a
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Nazareth, Helen, Stacy A. Genagon, and Thomas A. Russo. "Extraintestinal Pathogenic Escherichia coli Survives within Neutrophils." Infection and Immunity 75, no. 6 (2007): 2776–85. http://dx.doi.org/10.1128/iai.01095-06.

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ABSTRACT Extracellular pathogenic Escherichia coli (ExPEC) strains are common causes of a variety of clinical syndromes, including urinary tract infections, abdominal infections, nosocomial pneumonia, neonatal meningitis, and sepsis. ExPEC strains are extracellular bacterial pathogens; therefore, the innate immune response (e.g., professional phagocytes) plays a crucial role in the host defense against them. Studies using the model ExPEC strain CP9 demonstrated that it is relatively resistant to neutrophil-mediated bactericidal activity. Although this could be due to resistance to phagocytosis
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Potapov, A. F., T. M. Tyaptirgyanova, and A. N. Kirillin. "Detoxification in Abdominal Sepsis." General Reanimatology 1, no. 3 (2005): 32. http://dx.doi.org/10.15360/1813-9779-2005-3-32-35.

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Mureșan, Mircea Gabriel, Ioan Alexandru Balmoș, Iudita Badea, and Ario Santini. "Abdominal Sepsis: An Update." Journal of Critical Care Medicine 4, no. 4 (2018): 120–25. http://dx.doi.org/10.2478/jccm-2018-0023.

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Abstract Despite the significant development and advancement in antibiotic therapy, life-threatening complication of infective diseases cause hundreds of thousands of deaths world. This paper updates some of the issues regarding the etiology and treatment of abdominal sepsis and summaries the latest guidelines as recommended by the Intra-abdominal Infection (IAI) Consensus (2017). Prognostic scores are currently used to assess the course of peritonitis. Irrespective of the initial cause, there are several measures universally accepted as contributing to an improved survival rate, with the earl
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&NA;. "UNTREATED INTRA-ABDOMINAL SEPSIS." Journal of Trauma: Injury, Infection, and Critical Care 29, no. 7 (1989): 1037. http://dx.doi.org/10.1097/00005373-198907000-00068.

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