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Journal articles on the topic 'Human adipose tissue derived adult stem cells'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Brzoska, Martin, Helmut Geiger, Stefan Gauer, and Patrick Baer. "Epithelial differentiation of human adipose tissue-derived adult stem cells." Biochemical and Biophysical Research Communications 330, no. 1 (2005): 142–50. http://dx.doi.org/10.1016/j.bbrc.2005.02.141.

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2

Lina, Yani, and Andi Wijaya. "Adipose-Derived Stem Cells for Future Regenerative System Medicine." Indonesian Biomedical Journal 4, no. 2 (2012): 59. http://dx.doi.org/10.18585/inabj.v4i2.164.

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BACKGROUND: The potential use of stem cell-based therapies for repair and regeneration of various tissues and organs offers a paradigm shift that may provide alternative therapeutic solutions for a number of disease. Despite the advances, the availability of stem cells remaining a challenge for both scientist and clinicians in pursuing regenerative medicine. CONTENT: Subcutaneous human adipose tissue is an abundant and accessible cell source for applications in tissue engineering and regenerative medicine. Routinely, the adipose issue is digested with collagenase or related lytic enzymes to re

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3

Schreml, Stephan, Philipp Babilas, Sabine Fruth, et al. "Harvesting human adipose tissue-derived adult stem cells: resection versus liposuction." Cytotherapy 11, no. 7 (2009): 947–57. http://dx.doi.org/10.3109/14653240903204322.

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4

Boquest, A., A. Shahdadfar, K. Fronsdal, J. Brinchmann, and P. Collas. "167 ISOLATION AND COMPARATIVE PROFILING OF HUMAN ADIPOSE-DERIVED ADULT STEM CELLS." Reproduction, Fertility and Development 17, no. 2 (2005): 234. http://dx.doi.org/10.1071/rdv17n2ab167.

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The stromal compartment of mesenchymal tissues is thought to harbor stem cells that display extensive proliferative capacity and multilineage potential. However, despite their potential impact in the field of regenerative medicine, little is known about the biology of stromal stem cells prior to culture. After removing adipocytes and erythrocytes from collagenase digested human adipose tissue, we identified two cell populations using flow cytometry which shared expression of stem cell markers SH2 and CD34, but lacked the phenotypic characteristics of leukocytes (CD45−). However, they were foun

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Wang, Wei, Bin Cao, Lei Cui, Jinglong Cai, and Jingbo Yin. "Adipose tissue engineering with human adipose tissue-derived adult stem cells and a novel porous scaffold." Journal of Biomedical Materials Research Part B: Applied Biomaterials 101B, no. 1 (2012): 68–75. http://dx.doi.org/10.1002/jbm.b.32816.

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6

Hussein, Hussam Al, Marius Harpa, Ionela Movileanu, et al. "Minimally Invasive Surgical Protocol for Adipose Derived Stem Cells Collection and Isolation - Ovine Model." Revista de Chimie 70, no. 5 (2019): 1826–28. http://dx.doi.org/10.37358/rc.19.5.7224.

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Many methods of stem cells collection and isolation from various tissue types harvested either from small or large experimental animals or from human tissues have been published so far, all evaluating them as a potential source of adult mesenchymal stem cells with applicability in various pathologies or tissue bioengineering. The present study purposed to describe a minimally invasive surgical protocol for adipose tissue collection from sheep�s inter-scapular area. The procedure was carried out on adult sheeps, in aseptic conditions. A light sedation protocol with Detomidine was performed, the

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7

Fang, B., Y. Li, Y. Song, et al. "Human Adipose Tissue–Derived Adult Stem Cells Can Lead to Multiorgan Engraftment." Transplantation Proceedings 42, no. 5 (2010): 1849–56. http://dx.doi.org/10.1016/j.transproceed.2010.01.058.

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8

Dicker, Andrea, Katarina Le Blanc, Gaby Åström, et al. "Functional studies of mesenchymal stem cells derived from adult human adipose tissue." Experimental Cell Research 308, no. 2 (2005): 283–90. http://dx.doi.org/10.1016/j.yexcr.2005.04.029.

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9

Fang, Baijun, Suxia Luo, Yongping Song, Ning Li, and Ying Cao. "Hemangioblastic Characteristics of Human Adipose Tissue-derived Adult Stem Cells In Vivo." Archives of Medical Research 40, no. 4 (2009): 311–17. http://dx.doi.org/10.1016/j.arcmed.2009.04.007.

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10

Arumugam, SarasaBharati, OmanaA Trentz, Devi Arikketh, Vijayalakshmi Senthinathan, Barry Rosario, and P. V. A. Mohandas. "Detection of embryonic stem cell markers in adult human adipose tissue-derived stem cells." Indian Journal of Pathology and Microbiology 54, no. 3 (2011): 501. http://dx.doi.org/10.4103/0377-4929.85082.

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11

Pak, Jaewoo, Jung Hun Lee, and Sang Hee Lee. "Regenerative Repair of Damaged Meniscus with Autologous Adipose Tissue-Derived Stem Cells." BioMed Research International 2014 (2014): 1–10. http://dx.doi.org/10.1155/2014/436029.

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Mesenchymal stem cells (MSCs) are defined as pluripotent cells found in numerous human tissues, including bone marrow and adipose tissue. Such MSCs, isolated from bone marrow and adipose tissue, have been shown to differentiate into bone and cartilage, along with other types of tissues. Therefore, MSCs represent a promising new therapy in regenerative medicine. The initial treatment of meniscus tear of the knee is managed conservatively with nonsteroidal anti-inflammatory drugs and physical therapy. When such conservative treatment fails, an arthroscopic resection of the meniscus is necessary.

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12

Williams, K. J., R. A. Godke, and K. R. Bondioli. "288 CHARACTERIZATION OF PORCINE ADIPOSE TISSUE-DERIVED ADULT STEM CELL SURFACE PROTEINS." Reproduction, Fertility and Development 21, no. 1 (2009): 241. http://dx.doi.org/10.1071/rdv21n1ab288.

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Human adipose tissue-derived adult stem (ADAS) cells are a self-renewing population of cells with a multilineage plasticity similar to bone marrow-derived mesenchymal stem cells. Human ADAS have promise for use in combination with various biomaterials for reconstructive tissue engineering. The phenotypic profile of human ADAS cell surface proteins has been partially characterized for stem cell-associated cluster differentiation molecules including CD29, CD44, and CD90. Porcine ADAS cells, an animal model for tissue engineering, also have the ability to self-renew and differentiate into multipl

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13

Zhang, Chuanhai, Jing Jing Wang, Xiaoyun He, et al. "Characterization and Beige Adipogenic Potential of Human Embryo White Adipose Tissue-Derived Stem Cells." Cellular Physiology and Biochemistry 51, no. 6 (2018): 2900–2915. http://dx.doi.org/10.1159/000496042.

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Background/Aims: Brown and beige adipocytes are widely recognized as potential therapeutic targets to treat obesity and related metabolic disorders, and the recruitment of brown and beige adipocytes is an essential aspect that requires attention. Although many methods of activating brown adipocytes or generating beige adipocytes have been reported, the limited number and sources are the biggest challenges. The number of white adipocytes is much greater than the number of brown adipocytes, both in human adults and fetuses. Unfortunately, human adult white adipose tissue-derived stem cell (aWAsc

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14

Devitt, Sean M., Cynthia M. Carter, Raia Dierov, Scott Weiss, Robert P. Gersch, and Ivona Percec. "Successful Isolation of Viable Adipose-Derived Stem Cells from Human Adipose Tissue Subject to Long-Term Cryopreservation: Positive Implications for Adult Stem Cell-Based Therapeutics in Patients of Advanced Age." Stem Cells International 2015 (2015): 1–11. http://dx.doi.org/10.1155/2015/146421.

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We examined cell isolation, viability, and growth in adipose-derived stem cells harvested from whole adipose tissue subject to different cryopreservation lengths (2–1159 days) from patients of varying ages (26–62 years). Subcutaneous abdominal adipose tissue was excised during abdominoplasties and was cryopreserved. The viability and number of adipose-derived stem cells isolated were measured after initial isolation and after 9, 18, and 28 days of growth. Data were analyzed with respect to cryopreservation duration and patient age. Significantly more viable cells were initially isolated from t

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15

Puissant, Benedicte, Corinne Barreau, Philippe Bourin, et al. "Immunomodulatory effect of human adipose tissue-derived adult stem cells: comparison with bone marrow mesenchymal stem cells." British Journal of Haematology 129, no. 1 (2005): 118–29. http://dx.doi.org/10.1111/j.1365-2141.2005.05409.x.

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16

Zuk, Patricia A., Min Zhu, Peter Ashjian, et al. "Human Adipose Tissue Is a Source of Multipotent Stem Cells." Molecular Biology of the Cell 13, no. 12 (2002): 4279–95. http://dx.doi.org/10.1091/mbc.e02-02-0105.

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Much of the work conducted on adult stem cells has focused on mesenchymal stem cells (MSCs) found within the bone marrow stroma. Adipose tissue, like bone marrow, is derived from the embryonic mesenchyme and contains a stroma that is easily isolated. Preliminary studies have recently identified a putative stem cell population within the adipose stromal compartment. This cell population, termed processed lipoaspirate (PLA) cells, can be isolated from human lipoaspirates and, like MSCs, differentiate toward the osteogenic, adipogenic, myogenic, and chondrogenic lineages. To confirm whether adipo

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17

Ronzière, M. C., E. Perrier, F. Mallein-Gerin, and A. M. Freyria. "Chondrogenic potential of bone marrow- and adipose tissue-derived adult human mesenchymal stem cells." Bio-Medical Materials and Engineering 20, no. 3-4 (2010): 145–58. http://dx.doi.org/10.3233/bme-2010-0626.

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18

Gonzalez-Rey, E., P. Anderson, M. A. Gonzalez, L. Rico, D. Buscher, and M. Delgado. "Human adult stem cells derived from adipose tissue protect against experimental colitis and sepsis." Gut 58, no. 7 (2009): 929–39. http://dx.doi.org/10.1136/gut.2008.168534.

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19

Franco Lambert, Ana Paula, Aline Fraga Zandonai, Diego Bonatto, Denise Cantarelli Machado, and João Antônio Pêgas Henriques. "Differentiation of human adipose-derived adult stem cells into neuronal tissue: Does it work?" Differentiation 77, no. 3 (2009): 221–28. http://dx.doi.org/10.1016/j.diff.2008.10.016.

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20

Rogers, Eve H., Sandra A. Fawcett, Vanja Pekovic-Vaughan, and John A. Hunt. "Comparing Circadian Dynamics in Primary Derived Stem Cells from Different Sources of Human Adult Tissue." Stem Cells International 2017 (2017): 1–13. http://dx.doi.org/10.1155/2017/2057168.

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Optimising cell/tissue constructs so that they can be successfully accepted and integrated within a host body is essential in modern tissue engineering. To do this, adult stem cells are frequently utilised, but there are many aspects of their environment in vivo that are not completely understood. There is evidence to suggest that circadian rhythms and daily circadian temporal cues have substantial effects on stem cell activation, cell cycle, and differentiation. It was hypothesised that the circadian rhythm in human adult stem cells differs depending on the source of tissue and that different

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21

Picou, A. A., S. L. Bartolotta, K. J. Williams, A. M. Giraldo, R. A. Godke, and K. R. Bondioli. "395 ISOLATION AND CHARACTERIZATION OF PORCINE ADIPOSE-DERIVED ADULT STEM CELLS." Reproduction, Fertility and Development 19, no. 1 (2007): 313. http://dx.doi.org/10.1071/rdv19n1ab395.

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A dipose-derived adult stem (ADAS) cells have been proposed as an alternative to embryonic stem cells for tissue engineering applications. Stromal cells isolated from human adipose tissue are self-renewing, can be induced to differentiate along several mesenchymal tissue lineages, and are characterized by a high expression of CD34 and CD44 stem cell markers. The objective of this study was to develop a protocol for the isolation and culture of porcine ADAS cells and to determine stem cell-like characteristics such as the ability to differentiate into multiple cell lineages and expression of CD

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22

Muñoz, Mario F., Sandro Argüelles, Francesco Marotta, Mario Barbagallo, Mercedes Cano, and Antonio Ayala. "Effect of Age and Lipoperoxidation in Rat and Human Adipose Tissue-Derived Stem Cells." Oxidative Medicine and Cellular Longevity 2020 (December 9, 2020): 1–20. http://dx.doi.org/10.1155/2020/6473279.

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A wide range of clinical applications in regenerative medicine were opened decades ago with the discovery of adult stem cells. Highly promising adult stem cells are mesenchymal stem/stromal cells derived from adipose tissue (ADSCs), primarily because of their abundance and accessibility. These cells have multipotent properties and have been used extensively to carry out autologous transplants. However, the biology of these cells is not entirely understood. Among other factors, the regeneration capacity of these cells will depend on both their capacity of proliferation/differentiation and the r

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23

Lattanzi, Wanda, Maria Concetta Geloso, Nathalie Saulnier, et al. "Neurotrophic Features of Human Adipose Tissue-Derived Stromal Cells:In VitroandIn VivoStudies." Journal of Biomedicine and Biotechnology 2011 (2011): 1–9. http://dx.doi.org/10.1155/2011/468705.

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Due to its abundance, easy retrieval, and plasticity characteristics, adipose-tissue-derived stromal cells (ATSCs) present unquestionable advantages over other adult-tissue-derived stem cells. Based on thein silicoanalysis of our previous data reporting the ATSC-specific expression profiles, the present study attempted to clarify and validate at the functional level the expression of the neurospecific genes expressed by ATSC bothin vitroandin vivo. This allowed evidencing that ATSCs express neuro-specific trophins, metabolic genes, and neuroprotective molecules. They were in fact able to induc

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Mueller, Paula, Markus Wolfien, Katharina Ekat, et al. "RNA-Based Strategies for Cardiac Reprogramming of Human Mesenchymal Stromal Cells." Cells 9, no. 2 (2020): 504. http://dx.doi.org/10.3390/cells9020504.

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Multipotent adult mesenchymal stromal cells (MSCs) could represent an elegant source for the generation of patient-specific cardiomyocytes needed for regenerative medicine, cardiovascular research, and pharmacological studies. However, the differentiation of adult MSC into a cardiac lineage is challenging compared to embryonic stem cells or induced pluripotent stem cells. Here we used non-integrative methods, including microRNA and mRNA, for cardiac reprogramming of adult MSC derived from bone marrow, dental follicle, and adipose tissue. We found that MSC derived from adipose tissue can partly

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25

Heidari, Alireza. "Vibrational Biospectroscopic Study on Biomedical and Clinical Engineering of Cancer Cells Fingerprints." Advanced Science, Engineering and Medicine 12, no. 10 (2020): 1272–84. http://dx.doi.org/10.1166/asem.2020.2684.

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In the current research, spontaneous vibrational spectra resulted from two cells samples are investigated. The first sample, a mesenchymal stem cell derived from adipose tissue, is a sample of adult stem cell, which derived from human adipose tissue. The second sample was HepG2 cancer cell which used as control cell. To reduce the effect of fluorescence during biospectroscopy, samples were cultured on quartz medium. Fifteen vibrational spectra were recorded for each sample and after processing and averaging, their differences were studied and it was identified that this technique can be used a

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26

Yang, Erfang, Na Liu, Yingxin Tang, et al. "Generation of Neurospheres from Human Adipose-Derived Stem Cells." BioMed Research International 2015 (2015): 1–10. http://dx.doi.org/10.1155/2015/743714.

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Transplantation of neural stem cells (NSCs) to treat neurodegenerative disease shows promise; however, the clinical application of NSCs is limited by the invasive procurement and ethical concerns. Adipose-derived stem cells (ADSCs) are a source of multipotent stem cells that can self-renew and differentiate into various kinds of cells; this study intends to generate neurospheres from human ADSCs by culturing ADSCs on uncoated culture flasks in serum-free neurobasal medium supplemented with B27, basic fibroblast growth factor (bFGF), and epidermal growth factor (EGF); the ADSCs-derived neurosph

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Lima, A., E. Monaco, S. Wilson, et al. "286 OSTEOGENIC DIFFERENTIATION IN VITRO OF PORCINE ADULT MESENCHYMAL STEM CELLS." Reproduction, Fertility and Development 20, no. 1 (2008): 223. http://dx.doi.org/10.1071/rdv20n1ab286.

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The quantity and accessibility of subcutaneous adipose tissue in humans make it an attractive alternative to bone marrow as a source of adult stem cells for therapeutic purposes. However, before such a cell source substitution can be proposed, the properties of stem cells derived from adipose (ADSCs) and bone marrow (MSCs) and their differentiated progeny must be compared in an animal model that adequately simulates the structure and physiology of humans. The objective of this work was to induce adult porcine stem cells isolated from subcutaneous adipose tissue and bone marrow to differentiate

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Lim, S. M. L., I. Aksoy, K. G. C. Lim, et al. "Re-establishing pluripotency in adult cells derived from breast stromal tissue." Journal of Clinical Oncology 29, no. 27_suppl (2011): 227. http://dx.doi.org/10.1200/jco.2011.29.27_suppl.227.

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227 Background: Recent advances in pluripotent stem cell biology offer patient-specific disease models to investigate in vitro mechanisms of tumorigenesis. Induced pluripotent stem (iPS) cells were originally derived by reprogramming of human dermal fibroblasts through ectopic expression of pluripotency–associated transcription factors. A limitation to the use of dermal fibroblasts as the starting cell type for reprogramming is that it usually takes weeks to expand cells from a single biopsy, and the efficiency of the process is very low. In contrast, a large number of adipose-derived mesenchy

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Wankhade, Umesh D., Michael Shen, Ravindra Kolhe, and Sadanand Fulzele. "Advances in Adipose-Derived Stem Cells Isolation, Characterization, and Application in Regenerative Tissue Engineering." Stem Cells International 2016 (2016): 1–9. http://dx.doi.org/10.1155/2016/3206807.

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Obesity is a complex, multifactorial disease that has been extensively researched in recent times. Obesity is characterized by excess deposition of adipose tissue in response to surplus energy. Despite the negative connotations of adipose tissue (AT), it serves as a critical endocrine organ. Adipose tissue is a source of several adipokines and cytokines which have been deemed important for both normal metabolic function and disease formation. The discoveries of metabolically active brown AT in adult humans and adipose tissue derived stem cells (ADSC) have been key findings in the past decade w

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Monaco, E., A. Lima, S. Wilson, et al. "282 ADIPOGENIC DIFFERENTIATION IN VITRO OF PORCINE ADULT MESENCHYMAL STEM CELLS." Reproduction, Fertility and Development 21, no. 1 (2009): 238. http://dx.doi.org/10.1071/rdv21n1ab282.

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The quantity and accessibility of subcutaneous adipose tissue in humans make it an attractive alternative to bone marrow as a source of adult stem cells for therapeutic purposes. However, before such a cell source substitution can be proposed, the properties of stem cells derived from adipose tissue (ADSC) and bone marrow (BMSC), and their differentiated progeny must be compared in an animal model, such as swine, that adequately simulates the structure and physiology of humans. The objective of this work was to induce adult porcine stem cells isolated from subcutaneous adipose tissue and bone

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31

Gruenloh, William, Amal Kambal, Claus Sondergaard, et al. "Characterization and In Vivo Testing of Mesenchymal Stem Cells Derived From Human Embryonic Stem Cells." Blood 114, no. 22 (2009): 1451. http://dx.doi.org/10.1182/blood.v114.22.1451.1451.

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Abstract Abstract 1451 Poster Board I-474 Mesenchymal stem cells (MSC, aka marrow stromal cells) present a promising tool for cell therapy, and have been shown to contribute to the recovery of tissues in myocardial infarction, stroke, meniscus injury, limb ischemia, and even neurodegenerative disorders. The percentage of engrafted MSC in these studies has been very low in comparison to the recipient tissue cells, suggesting that their efficacy relies upon actions other than differentiation. One theory of tissue repair and regeneration by adult MSC is that the injected stem cells home to the in

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Barbagallo, Ignazio, Giovanni Li Volti, Fabio Galvano, et al. "Diabetic human adipose tissue-derived mesenchymal stem cells fail to differentiate in functional adipocytes." Experimental Biology and Medicine 242, no. 10 (2016): 1079–85. http://dx.doi.org/10.1177/1535370216681552.

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Adipose tissue dysfunction represents a hallmark of diabetic patients and is a consequence of the altered homeostasis of this tissue. Mesenchymal stem cells (MSCs) and their differentiation into adipocytes contribute significantly in maintaining the mass and function of adult adipose tissue. The aim of this study was to evaluate the differentiation of MSCs from patients suffering type 2 diabetes (dASC) and how such process results in hyperplasia or rather a stop of adipocyte turnover resulting in hypertrophy of mature adipocytes. Our results showed that gene profile of all adipogenic markers i

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33

Wilson, S. M., E. Monaco, M. S. Goldwasser, S. G. Clark, W. L. Hurley, and M. B. Wheeler. "401 MIGRATION AND THERAPEUTIC POTENTIAL OF PORCINE ADULT ADIPOSE-DERIVED MESENCHYMAL STEM CELLS." Reproduction, Fertility and Development 22, no. 1 (2010): 357. http://dx.doi.org/10.1071/rdv22n1ab401.

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Bone marrow is one current source of adult stem cells for therapeutic purposes; however, the magnitude and accessibility of subcutaneous adipose tissue in humans make it an attractive alternative. Numerous in vitro studies have been conducted to determine how these cells act in vitro, but it is imperative to determine the vast abilities of these cells in vivo. The objective of this study was to evaluate in vivo migration and bone healing ability after transplanting adipose-derived stem cells (ADSC) in a swine model. Adipose-derived stem cells were isolated from subcutaneous adipose tissue of a

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Ezquerra, Sarah, Amparo Zuleta, Rodrigo Arancibia, José Estay, Francisco Aulestia, and Flavio Carrion. "Functional Properties of Human-Derived Mesenchymal Stem Cell Spheroids: A Meta-Analysis and Systematic Review." Stem Cells International 2021 (April 4, 2021): 1–12. http://dx.doi.org/10.1155/2021/8825332.

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Mesenchymal stem cells (MSC) are adult multi-potent cells that can be isolated from many types of tissues including adipose tissue, bone marrow, and umbilical cord. They show great potential for cell therapy-based treatments, which is why they are being used in numerous clinical trials for a wide range of diseases. However, the success of placebo-controlled clinical trials has been limited, so new ways of improving the therapeutic effects of MSC are being developed, such as their assembly in a 3D conformation. In this meta-analysis, we review aggregate formation, in vitro functional properties

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Shin, Soyoung, Yonggoo Kim, Sikyoung Jeong, et al. "The Therapeutic Effect of Human Adult Stem Cells Derived from Adipose Tissue in Endotoxemic Rat Model." International Journal of Medical Sciences 10, no. 1 (2013): 8–18. http://dx.doi.org/10.7150/ijms.5385.

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36

Lee, Song, Seonghee Jeong, Chanmi Lee, Jooyun Oh, and Song-Cheol Kim. "Mesenchymal Stem Cells Derived from Human Exocrine Pancreas Spontaneously Express Pancreas Progenitor-Cell Markers in a Cell-Passage-Dependent Manner." Stem Cells International 2016 (2016): 1–12. http://dx.doi.org/10.1155/2016/2142646.

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Mesenchymal stem cells (MSCs) derived from bone marrow, adipose tissue, and most connective tissues have been recognized as promising sources for cell-based therapies. MSCs have also been detected in human pancreatic tissue, including endocrine and exocrine cells. These adult human pancreas-derived MSCs have generated a great deal of interest owing to their potential use in the differentiation of insulin-producing cells for diabetes treatment. In the present study, we isolated MSCs from the adult human exocrine pancreas to determine whether isolated MSCs have the potential to differentiate int

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37

Coley, L. W., M. K. Addison, G. T. Gentry, R. A. Godke, and K. R. Bondioli. "208 REPROGRAMMING OF BOVINE SOMATIC CELLS WITH CELLULAR EXTRACTS FROM ADIPOSE-DERIVED ADULT STEM CELLS AND HUMAN EMBRYONIC STEM CELLS." Reproduction, Fertility and Development 24, no. 1 (2012): 216. http://dx.doi.org/10.1071/rdv24n1ab208.

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The differentiation potential of adult stem cells (ASC) has long been considered limited to the cell types present in the organ or tissue from which they are derived. Several studies have challenged this notion by demonstrating that ASC exhibit a high degree of plasticity; therefore, it is likely that these cells possess an epigenomic regulatory pattern more like pluripotent cells than somatic cells. In the present study, we used quantitative RT-PCR (qRT-PCR) to analyse bovine adipose-derived adult stem cells (ADAS) and bovine fetal fibroblasts (BFF) for the presence of Oct-4, Nanog and Sox-2.

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38

Lee, So Eun, Young Mee Jung, Soo Hyun Kim, et al. "Cartilaginous Tissue Formation with an Elastic PLCL Scaffold and Human Adipose Tissue-Derived Stromal Cells." Key Engineering Materials 342-343 (July 2007): 385–88. http://dx.doi.org/10.4028/www.scientific.net/kem.342-343.385.

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In cartilage tissue engineering, as a cell source, adult stem cells are very attractive for clinical applications. Recent studies suggest that human adipose tissue-derived stromal cells (ASCs) have multilineage potential similar to bone marrow-derived stromal cells (BMSCs). ASCs are obtained from adipose tissue easily isolated by suction-assisted lipectomy in various body parts. Also, as one of major factors of cartilage tissue engineering, scaffolds have an important role in cartilage formation. Poly(L-lactide-co-ε-carprolactone) scaffolds have physiological activity, biodegradability, high c

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39

Hahn, Olga, Lena-Christin Ingwersen, Abdelrahman Soliman, et al. "TGF-ß1 Induces Changes in the Energy Metabolism of White Adipose Tissue-Derived Human Adult Mesenchymal Stem/Stromal Cells In Vitro." Metabolites 10, no. 2 (2020): 59. http://dx.doi.org/10.3390/metabo10020059.

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Adipose tissue plays an active role in the regulation of the body’s energy balance. Mesenchymal stem/stromal cells from adipose tissue (adMSC) are the precursor cells for repair and adipogenesis. Since the balance of the differentiation state of adipose tissue-resident cells is associated with the development of various diseases, the examination of the regulation of proliferation and differentiation of adMSC might provide new therapeutic targets. Transforming growth factor-β1 (TGF-ß1) is synthetized by many cell types and is involved in various biological processes. Here, we investigated the e

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40

Garrovo, Chiara, Natascha Bergamin, Dave Bates, et al. "In Vivo Tracking of Murine Adipose Tissue-Derived Multipotent Adult Stem Cells and Ex Vivo Cross-Validation." International Journal of Molecular Imaging 2013 (January 17, 2013): 1–13. http://dx.doi.org/10.1155/2013/426961.

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Stem cells are characterized by the ability to renew themselves and to differentiate into specialized cell types, while stem cell therapy is believed to treat a number of different human diseases through either cell regeneration or paracrine effects. Herein, an in vivo and ex vivo near infrared time domain (NIR TD) optical imaging study was undertaken to evaluate the migratory ability of murine adipose tissue-derived multipotent adult stem cells [mAT-MASC] after intramuscular injection in mice. In vivo NIR TD optical imaging data analysis showed a migration of DiD-labelled mAT-MASC in the leg

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Pitrone, Maria, Giuseppe Pizzolanti, Antonina Coppola, et al. "Knockdown of NANOG Reduces Cell Proliferation and Induces G0/G1 Cell Cycle Arrest in Human Adipose Stem Cells." International Journal of Molecular Sciences 20, no. 10 (2019): 2580. http://dx.doi.org/10.3390/ijms20102580.

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The core components of regenerative medicine are stem cells with high self-renewal and tissue regeneration potentials. Adult stem cells can be obtained from many organs and tissues. NANOG, SOX2 and OCT4 represent the core regulatory network that suppresses differentiation-associated genes, maintaining the pluripotency of mesenchymal stem cells. The roles of NANOG in maintaining self-renewal and undifferentiated status of adult stem cells are still not perfectly established. In this study we define the effects of downregulation of NANOG in maintaining self-renewal and undifferentiated state in

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Gentile, Pietro, Claudio Calabrese, Barbara De Angelis, Jacopo Pizzicannella, Ashutosh Kothari, and Simone Garcovich. "Impact of the Different Preparation Methods to Obtain Human Adipose-Derived Stromal Vascular Fraction Cells (AD-SVFs) and Human Adipose-Derived Mesenchymal Stem Cells (AD-MSCs): Enzymatic Digestion Versus Mechanical Centrifugation." International Journal of Molecular Sciences 20, no. 21 (2019): 5471. http://dx.doi.org/10.3390/ijms20215471.

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Autologous therapies using adipose-derived stromal vascular fraction (AD-SVFs) and adult adipose-derived mesenchymal stem cells (AD-MSCs) warrant careful preparation of the harvested adipose tissue. Currently, no standardized technique for this preparation exists. Processing quantitative standards (PQSs) define manufacturing quantitative variables (such as time, volume, and pressure). Processing qualitative standards (PQLSs) define the quality of the materials and methods in manufacturing. The purpose of the review was to use PQSs and PQLSs to report the in vivo and in vitro results obtained b

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El-Deftar, Mervat Mohamed Fouad, Alla El Din Mohamed, and Ahmed El-Ghannam. "Regeneration of Critical-Size Canine Calvarial Defect by Silica-Calcium Phosphate-Composite (SCPC) and Human Adipose Derived Stem Cells." Key Engineering Materials 758 (November 2017): 264–68. http://dx.doi.org/10.4028/www.scientific.net/kem.758.264.

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Reconstruction of large maxillofacial bone defects remains challenging even with diverse current treatment modalities. Silica-calcium phosphate nano composite (SCPC) is a resorbable bioactive bone graft material with a strong stimulatory effect on osteogenic gene expression of osteoblasts and mineralized tissue formation. In a prospective experimental study we investigated the ability of SCPC scaffold seeded with human adipose derived stem cells (ADSCs) to regenerate bone in a critical-size canine calvarial defect. Porous SCPC discs were prepared by powder metallurgy method. ADSCs were isolate

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Ratushnyy, Andrey, Mariia Ezdakova, and Ludmila Buravkova. "Secretome of Senescent Adipose-Derived Mesenchymal Stem Cells Negatively Regulates Angiogenesis." International Journal of Molecular Sciences 21, no. 5 (2020): 1802. http://dx.doi.org/10.3390/ijms21051802.

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Nowadays, paracrine regulation is considered as a major tool of mesenchymal stem cell (MSC) involvement in tissue repair and renewal in adults. Aging results in alteration of tissue homeostasis including neovascularization. In this study, we examined the influence of replicative senescence on the angiogenic potential of adipose-derived MSCs (ASCs). Angiogenic activity of conditioned medium (CM) from senescent and “young” ASCs was evaluated in chorioallantoic membrane (CAM) assay in ovo using Japanese quail embryos. Also, the formation of capillary-like tubes by human umbilical vein endothelial

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Azadian, Zahra, Masoomeh Shafiei, Saadi Hosseini, Javad Kazemi, Atefeh Alipour, and Hosein Shahsavarani. "Efficient In Vitro Differentiation of Adipose Tissue-Derived Mesenchymal Stem Cells Into the Cardiomyocyte Using Plant-Derived Natural Compounds." Proceedings of the Singapore National Academy of Science 13, no. 01 (2019): 47–63. http://dx.doi.org/10.1142/s2591722619400064.

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Various degenerative diseases, traumatic injuries and cancers are almost hard to treat with conventional therapies, causing death or at least permanent disability. The use of multipotent adipose-derived mesenchymal stem cells (ADMSCs) for cell-based therapeutic applications has lately drawn elevated attention primarily due to their potential for differentiation into mesodermal lineages, which can finally be converted into cardiomyocytes to replace present invasive methods used to treat cardiac diseases. However, some reports hindered their clinical implementation due to concerns about efficacy

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Alfaro, David, Mariano R. Rodríguez-Sosa, and Agustín G. Zapata. "Eph/ephrin Signaling and Biology of Mesenchymal Stromal/Stem Cells." Journal of Clinical Medicine 9, no. 2 (2020): 310. http://dx.doi.org/10.3390/jcm9020310.

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Mesenchymal stromal/stem cells (MSCs) have emerged as important therapeutic agents, owing to their easy isolation and culture, and their remarkable immunomodulatory and anti-inflammatory properties. However, MSCs constitute a heterogeneous cell population which does not express specific cell markers and has important problems for in vivo homing, and factors regulating their survival, proliferation, and differentiation are largely unknown. Accordingly, in the present article, we review the current evidence on the relationships between Eph kinase receptors, their ephrin ligands, and MSCs. These

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Wu, Xuanye, Nils Schneider, Alina Platen, et al. "In situ characterization of the mTORC1 during adipogenesis of human adult stem cells on chip." Proceedings of the National Academy of Sciences 113, no. 29 (2016): E4143—E4150. http://dx.doi.org/10.1073/pnas.1601207113.

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Mammalian target of rapamycin (mTOR) is a central kinase integrating nutrient, energy, and metabolite signals. The kinase forms two distinct complexes: mTORC1 and mTORC2. mTORC1 plays an essential but undefined regulatory function for regeneration of adipose tissue. Analysis of mTOR in general is hampered by the complexity of regulatory mechanisms, including protein interactions and/or phosphorylation, in an ever-changing cellular microenvironment. Here, we developed a microfluidic large-scale integration chip platform for culturing and differentiating human adipose-derived stem cells (hASCs)

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Mattsson, Charlotte L., Robert I. Csikasz, Ekaterina Chernogubova та ін. "β1-Adrenergic receptors increase UCP1 in human MADS brown adipocytes and rescue cold-acclimated β3-adrenergic receptor-knockout mice via nonshivering thermogenesis". American Journal of Physiology-Endocrinology and Metabolism 301, № 6 (2011): E1108—E1118. http://dx.doi.org/10.1152/ajpendo.00085.2011.

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With the finding that brown adipose tissue is present and negatively correlated to obesity in adult man, finding the mechanism(s) of how to activate brown adipose tissue in humans could be important in combating obesity, type 2 diabetes, and their complications. In mice, the main regulator of nonshivering thermogenesis in brown adipose tissue is norepinephrine acting predominantly via β3-adrenergic receptors. However, vast majorities of β3-adrenergic agonists have so far not been able to stimulate human β3-adrenergic receptors or brown adipose tissue activity, and it was postulated that human

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Raynaud, C. M., M. Maleki, R. Lis, et al. "Comprehensive Characterization of Mesenchymal Stem Cells from Human Placenta and Fetal Membrane and Their Response to Osteoactivin Stimulation." Stem Cells International 2012 (2012): 1–13. http://dx.doi.org/10.1155/2012/658356.

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Mesenchymal stem cells (MSCs) are the most promising seed cells for cell therapy and can be isolated from various sources of human adult tissues such as bone marrow (BM-MSC) and adipose tissue. However, cells from these tissues must be obtained through invasive procedures. We, therefore, characterized MSCs isolated from fresh placenta (Pl-MSC) and fetal membrane (Mb-MSC) through morphological and fluorescent-activated cell sorting (FACS). MSC frequency is higher in membrane than placenta (2.14% ± 0.65 versus 15.67% ± 0.29%). Pl/Mb-MSCsin vitroexpansion potential was significantly higher than B

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He, X., S. C. H'ng, D. T. Leong, D. W. Hutmacher, and A. J. Melendez. "Sphingosine-1-Phosphate Mediates Proliferation Maintaining the Multipotency of Human Adult Bone Marrow and Adipose Tissue-derived Stem Cells." Journal of Molecular Cell Biology 2, no. 4 (2010): 199–208. http://dx.doi.org/10.1093/jmcb/mjq011.

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