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Journal articles on the topic 'Human antigen presenting cells'

Author: Grafiati

Published: 31 May 2025

Last updated: 31 July 2025

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1

Fenoglio, D., G. Li Pira, D. Saverino, et al. "Handling of retroviral antigens by human antigen-presenting cells." Research in Virology 147, no. 2-3 (1996): 97–101. http://dx.doi.org/10.1016/0923-2516(96)80222-6.

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2

Goebels, N., and R. Hohlfeld. "Human myoblasts as antigen presenting cells." Journal of Neuroimmunology 35 (January 1991): 67. http://dx.doi.org/10.1016/0165-5728(91)90959-b.

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3

Goebels, N., D. Michaelis, H. Wekerle, and R. Hohlfeld. "Human myoblasts as antigen-presenting cells." Journal of Immunology 149, no. 2 (1992): 661–67. http://dx.doi.org/10.4049/jimmunol.149.2.661.

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Abstract Human myoblasts, cultured from muscle and purified to greater than 95%, were investigated for their capacity to act as facultative APC. The myoblasts reacted with antidesmin mAb and had the capacity to fuse into multinucleated myotubes in appropriate medium. The expression of HLA class I, HLA-DR, HLA-DP, HLA-DQ, intercellular adhesion molecule-1 (ICAM-1/CD54), lymphocyte function-associated (LFA) molecules LFA-1 (CD11a/CD18), LFA-2 (CD2), and LFA-3 (CD58) was investigated by FACS analysis before and after induction for various times with human rIFN-gamma, TNF-alpha, or both. Without c

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4

Lehner, T. "Antigen presenting, contrasuppressor human T cells." Immunology Today 7, no. 3 (1986): 87–92. http://dx.doi.org/10.1016/0167-5699(86)90091-5.

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5

Vigouroux, Stéphane, Eric Yvon, Hans-Joachim Wagner, et al. "Induction of Antigen-Specific Regulatory T Cells following Overexpression of a Notch Ligand by Human B Lymphocytes." Journal of Virology 77, no. 20 (2003): 10872–80. http://dx.doi.org/10.1128/jvi.77.20.10872-10880.2003.

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ABSTRACT In mice, activation of the Notch pathway in T cells by antigen-presenting cells overexpressing Notch ligands favors differentiation of regulatory T lymphocytes responsible for antigen-specific tolerance. To determine whether this mechanism operates in human T cells, we used Epstein-Barr virus-positive lymphoblastoid cell lines (EBV-LCL) as our (viral) antigen-presenting cells and overexpressed the Notch ligand Jagged-1 (EBV-LCL J1) by adenoviral transduction. The EBV-LCL J1s were cocultured with autologous T cells, and the proliferative and cytotoxic responses to EBV antigens were mea

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6

Kaneko, T., T. Okiji, R. Kaneko, J. E. Nör, and H. Suda. "Antigen-presenting Cells in Human Radicular Granulomas." Journal of Dental Research 87, no. 6 (2008): 553–57. http://dx.doi.org/10.1177/154405910808700617.

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Substantial numbers of dendritic cells have been detected in radicular granulomas. To test the hypothesis that local antigen presentation from dendritic cells to T-cells is involved critically in immunological responses within radicular granulomas, we compared characteristics of dendritic cells and macrophages by morphological and biological analyses. Under light microscopy, HLA-DR+ and CD68+ cells showed diverse profiles, including dendritic-shaped cells. Transmission electron microscopy revealed that HLA-DR+ dendritic cells, with long cytoplasmic processes and lacking distinct phagosomes, we

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7

Ishida, Haruhiko, Shigemichi Iwae, and Mutsuo Amatsu. "Antigen-presenting Cells in Human Laryngeal Mucosa." Nihon Kikan Shokudoka Gakkai Kaiho 48, no. 3 (1997): 216–20. http://dx.doi.org/10.2468/jbes.48.216.

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8

OKSENBERG, J. R., S. MOR-YOSEF, E. PERSITZ, Y. SCHENKER, E. MOZES, and C. BRAUTBAR. "Antigen-Presenting Cells in Human Decidual Tissue." American Journal of Reproductive Immunology and Microbiology 11, no. 3 (1986): 82–88. http://dx.doi.org/10.1111/j.1600-0897.1986.tb00036.x.

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9

Antal, Dóra, Shahrzad Alimohammadi, Péter Bai, Attila Gábor Szöllősi, and Magdolna Szántó. "Antigen-Presenting Cells in Psoriasis." Life 12, no. 2 (2022): 234. http://dx.doi.org/10.3390/life12020234.

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Psoriasis is classically considered a chronic inflammatory skin disorder, however the identification of autoantigens in its pathogenesis established it as a T cell mediated autoimmune disease. As such professional antigen-presenting cells (APCs) are key players in the development of lesions. APCs in the skin include dendritic cells, Langerhans cells and monocytes/macrophages. In addition, epidermal keratinocytes and dermal mast cells are also endowed with antigen-presenting capacity. Skin APCs have central role in the maintenance of cutaneous immune homeostasis, as well as in initiating and su

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10

Yabu, Kouji, and Akihiko Yano. "Antigen Presentation by Human Antigen-Presenting Cells to Antigen-Specific Xenogeneic Murine T Cells." Microbiology and Immunology 30, no. 3 (1986): 237–48. http://dx.doi.org/10.1111/j.1348-0421.1986.tb00939.x.

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11

Hastings, Karen, Jennifer Nguyen, Richard Bernert, Christine Ko, Noemi Sebastiao, and Chengcheng Hu. "Gamma-interferon-inducible lysosomal thiol reductase is upregulated in human melanoma (TUM2P.1038)." Journal of Immunology 194, no. 1_Supplement (2015): 69.35. http://dx.doi.org/10.4049/jimmunol.194.supp.69.35.

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Abstract T cell-mediated immunity has the ability to produce durable anti-melanoma responses resulting in improved survival of patients with advanced melanoma. Antigen presentation in the tumor microenvironment directs anti-melanoma T cell responses. Gamma-interferon-inducible lysosomal thiol reductase (GILT) is critical for MHC class II-restricted presentation of multiple melanoma antigens to CD4+ T cells. However, GILT expression in melanoma has not been defined. We evaluated GILT and MHC class II expression in human primary and metastatic melanomas and nevi using immunohistochemistry. Both

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12

Fisher, R. I., J. Cossman, V. Diehl, and D. J. Volkman. "Antigen presentation by Hodgkin's disease cells." Journal of Immunology 135, no. 5 (1985): 3568–71. http://dx.doi.org/10.4049/jimmunol.135.5.3568.

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Abstract The L428 tumor cell line is a long-term tissue culture of Reed-Sternberg cells which was derived from the pleural effusion of a patient with Hodgkin's disease. The L428 cells express all known cell surface antigens, cytochemical staining, and cytologic features of freshly explanted Reed-Sternberg cells. In addition to the previously described HLA-DR cell surface antigens, the L428 cells are now demonstrated to express both DS and SB alloantigens. Thus, the L428 cells express all of the known subclasses of the human immune response genes that are located in the major histocompatibility

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13

Shan, Ming, Han-Fang Cheng, David Corry, and Farrah Kheradmand. "Lung antigen presenting cells in human emphysema (93.21)." Journal of Immunology 184, no. 1_Supplement (2010): 93.21. http://dx.doi.org/10.4049/jimmunol.184.supp.93.21.

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Abstract Exposure to tobacco smoke activates innate and adaptive immune responses that in long-term smokers have been linked to diseases of the lungs, cardiovascular system, joints, and other organs. The destruction of lung tissue that underlies smoking-induced emphysema has been associated with T helper 1 cells that recognize the matrix protein elastin. Factors that result in the development of such autoreactive T cells in smokers remain unknown but are crucial for further understanding the pathogenesis of systemic inflammatory diseases in smokers. Here, we show that lung myeloid dendritic ce

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14

Gemmell, E., C. L. Carter, D. N. J. Hart, K. E. Drysdale, and G. J. Seymour. "Antigen-presenting cells in human periodontal disease tissues." Oral Microbiology and Immunology 17, no. 6 (2002): 388–93. http://dx.doi.org/10.1034/j.1399-302x.2002.170609.x.

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15

VALLE, M. T., M. L. DEGL'INNOCENTI, R. BERTELLI, et al. "Antigen-presenting function of human peritoneum mesothelial cells." Clinical & Experimental Immunology 101, no. 1 (2008): 172–76. http://dx.doi.org/10.1111/j.1365-2249.1995.tb02294.x.

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16

Gabrielsen, Ingvild S. M., Hanna Helgeland, Helle Akselsen, et al. "Transcriptomes of antigen presenting cells in human thymus." PLOS ONE 14, no. 7 (2019): e0218858. http://dx.doi.org/10.1371/journal.pone.0218858.

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17

Raftery, Martin J., Manuel Hitzler, Florian Winau, et al. "Inhibition of CD1 Antigen Presentation by Human Cytomegalovirus." Journal of Virology 82, no. 9 (2008): 4308–19. http://dx.doi.org/10.1128/jvi.01447-07.

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ABSTRACT The betaherpesvirus human cytomegalovirus (HCMV) encodes several molecules that block antigen presentation by the major histocompatibility complex (MHC) proteins. Humans also possess one other family of antigen-presenting molecules, the CD1 family; however, the effect of HCMV on CD1 expression is unknown. The majority of CD1 molecules are classified on the basis of homology as group 1 CD1 and are present almost exclusively on professional antigen-presenting cells such as dendritic cells, which are a major target for HCMV infection and latency. We have determined that HCMV encodes mult

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18

Hari, Aswin, and Yan Shi. "Plasma Membrane Interactions that determine Antigen Presentation by Antigen-Presenting Cells (106.20)." Journal of Immunology 188, no. 1_Supplement (2012): 106.20. http://dx.doi.org/10.4049/jimmunol.188.supp.106.20.

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Abstract Antigen presentation is a critical process in host defense for initiating adaptive immune responses. The APC loads peptides derived from antigens onto major histocompatibility complex (MHC) molecules and exports them to the surface for T cells sampling. If the primary interaction between an APC and T cell is successful, i.e. the TCR binds an appropriate MHC-peptide complex, this leads to an adaptive immune response. Peptide antigens are presented on two types of MHC molecules, MHC I and MHC II via several distinct processing pathways. In turn, the MHC molecule dictates which type of T

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19

Shimabukuro-Vornhagen, Alexander, Eisei Kondo, Tanja Liebig, and Michael von Bergwelt-Baildon. "Activated human B cells: stimulatory or tolerogenic antigen-presenting cells?" Blood 114, no. 3 (2009): 746–47. http://dx.doi.org/10.1182/blood-2009-03-212886.

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20

Alisi, Anna, Paolo Romania, Valerio Nobili, Franco Locatelli, and Doriana Fruci. "Human hepatic stellate cells are liver-resident antigen-presenting cells." Hepatology 54, no. 3 (2011): 1107. http://dx.doi.org/10.1002/hep.24511.

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21

Affandi, Alsya J., Joanna Grabowska, Katarzyna Olesek, et al. "Selective tumor antigen vaccine delivery to human CD169+antigen-presenting cells using ganglioside-liposomes." Proceedings of the National Academy of Sciences 117, no. 44 (2020): 27528–39. http://dx.doi.org/10.1073/pnas.2006186117.

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Priming of CD8+T cells by dendritic cells (DCs) is crucial for the generation of effective antitumor immune responses. Here, we describe a liposomal vaccine carrier that delivers tumor antigens to human CD169/Siglec-1+antigen-presenting cells using gangliosides as targeting ligands. Ganglioside-liposomes specifically bound to CD169 and were internalized by in vitro-generated monocyte-derived DCs (moDCs) and macrophages and by ex vivo-isolated splenic macrophages in a CD169-dependent manner. In blood, high-dimensional reduction analysis revealed that ganglioside-liposomes specifically targeted

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22

Umetsu, D. T., D. Katzen, H. H. Jabara, and R. S. Geha. "Antigen presentation by human dermal fibroblasts: activation of resting T lymphocytes." Journal of Immunology 136, no. 2 (1986): 440–45. http://dx.doi.org/10.4049/jimmunol.136.2.440.

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Abstract We have shown that human dermal fibroblasts, exposed to interferon-gamma (IFN-gamma) to induce surface class II major histocompatibility complex (MHC) antigens, were capable of presenting tetanus toxoid (TT) antigen to human TT-specific T cell clones. Antigen presentation by fibroblasts was antigen dependent, required HLA-DR expression by fibroblasts, and was MHC restricted. In contrast, we now report that IFN-gamma-treated fibroblasts are unable to present TT antigen to purified resting T cells obtained from the peripheral blood of TT-immune donors. In addition, although IFN-gamma-tr

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23

Bjercke, S., L. Braathen, G. Gaudernack, and E. Thorsby. "Relative efficiency of human Langerhans´ cells and blood derived dendritic cells as antigen-presenting cells." Acta Dermato-Venereologica 65, no. 5 (1985): 374–78. http://dx.doi.org/10.2340/0001555565374378.

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T4 cells recognize antigens together with HLA class II molecules in the membrane of antigen-presenting cells (APC). The magnitude of the induced T cell response is in part dependent upon the APC´s amount of MHC-class II molecules. Langerhans´ dendritic cells (LC) express 50-100 times more HLA-DR molecules than monocytes (Mo) and blood derived dendritic cells (DC). We report here that LC are more efficient APC than DC from the same donor, indicating that the APC capacity of dendritic cells isolated from different organs is correlated to their expression of HLA class II gene products.

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24

Kang, Si-Sim, Ariel Isser, and Jonathan P. Schneck. "Using nanoparticles as artificial antigen presenting cells to mobilize CD4 T cells for immunotherapy." Journal of Immunology 210, no. 1_Supplement (2023): 250.12. http://dx.doi.org/10.4049/jimmunol.210.supp.250.12.

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Abstract CD4 T cell-based adoptive cell transfer (ACT) therapies have clinical success across multiple cancer types, including metastatic melanoma and epithelial cancer. One of the challenges of ACT therapy is finding methods to expand tumor antigen-specific T cells ex vivo. Therefore, engineering platforms for antigen-specific T cell expansion are critical since they provide greater control over studying T cell biology and have significant translational relevance. We developed a nanoscale platform that expands murine and human antigen-specific T cells in vitro. This artificial antigen-present

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25

Mayya, Viveka, Edward Judokusumo, Ricardo Medina, et al. "Bias in synapse stability leads to suppression of naive CD8 T cell activation by memory CD8 T cells during secondary responses (IRC9P.709)." Journal of Immunology 192, no. 1_Supplement (2014): 191.10. http://dx.doi.org/10.4049/jimmunol.192.supp.191.10.

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Abstract T cells can form either a stable synapse or a mobile junction termed kinapse when interacting with antigen presenting cells during an immune response. Stable synapses can lead to long dwell times with antigen presenting cells, whereas mobile kinapses likely favor transient interactions with antigen presenting cells. The underlying cell-intrinsic mechanisms determining the mode of interaction as well as their specific immunological consequences are not known. We have implemented methods borrowed from computer-vision and machine-learning disciplines to accurately quantify the positional

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26

van Dinther, Dieke, Miguel Lopez Venegas, Henrike Veninga, et al. "Activation of CD8+ T Cell Responses after Melanoma Antigen Targeting to CD169+ Antigen Presenting Cells in Mice and Humans." Cancers 11, no. 2 (2019): 183. http://dx.doi.org/10.3390/cancers11020183.

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The lack of tumor-reactive T cells is one reason why immune checkpoint inhibitor therapies still fail in a significant proportion of melanoma patients. A vaccination that induces melanoma-specific T cells could potentially enhance the efficacy of immune checkpoint inhibitors. Here, we describe a vaccination strategy in which melanoma antigens are targeted to mouse and human CD169 and thereby induce strong melanoma antigen-specific T cell responses. CD169 is a sialic acid receptor expressed on a subset of mouse splenic macrophages that captures antigen from the blood and transfers it to dendrit

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27

Shimabukuro-Vornhagen, Alexander, Tanja Liebig, Shahram Zoghi, Clemens M. Wendtner, and Michael S. von Bergwelt-Baildon. "Statins Inhibit the Function of Human Antigen-Presenting Cells." Blood 112, no. 11 (2008): 2560. http://dx.doi.org/10.1182/blood.v112.11.2560.2560.

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Abstract Statins are lipid-lowering drugs that reduce cholesterol production by inhibition of HMG-CoA reductase, the rate-limiting enzyme of the mevalonate pathway. It recently has been shown that statins, apart from their lipid-lowering action, have pleiotropic effects on the immune system. They possess immunomodulatory and anti-inflammatory activity. Our analysis of gene expression data comparing resting B cells with CD40-activated B cells, which are potent antigen-presenting cells (APC), showed that following CD40-activation expression of the enzymes in the mevalonate pathway was up-regulat

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28

Battaini, F., D. Besusso, L. Sfondrini, et al. "Antibody Response after Vaccination with Antigen-Pulsed Dendritic Cells." International Journal of Biological Markers 19, no. 3 (2004): 213–20. http://dx.doi.org/10.1177/172460080401900306.

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Dendritic cells (DCs) are the most potent antigen-presenting cells of the immune system capable of initiating immune responses to antigens. It is also well documented that cancer patients often experience anergy against tumor antigens. In this study we selected the best protocol for inducing the production of antibodies against the HER2 oncoprotein using DCs to overcome anergy. Murine DCs were pulsed in vitro, using different protocols, with recombinant HER2 fused to a human Fc (in order to improve DC antigen uptake) and were used to vaccinate mice. The obtained results indicate that antigen-p

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29

Bruno, Tullia Carmela, Peggy Ebner, Brandon Moore, et al. "Antigen-presenting tumor B cells impact the phenotype of CD4 tumor infiltrating T cells in lung cancer patients." Journal of Immunology 198, no. 1_Supplement (2017): 130.26. http://dx.doi.org/10.4049/jimmunol.198.supp.130.26.

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Abstract The focus of immunotherapy has been on CD8 and CD4 tumor infiltrating lymphocytes (TILs), however, tumor infiltrating B cells (TIL-Bs) are understudied with no focus on their role as antigen presenting cells. We hypothesize that TIL-Bs help generate potent, long-term immune responses against cancer by presenting tumor antigens to CD4 TILs. Using un-manipulated, primary human B cells from fresh tumor, we generated a specific in vitro antigen presentation assay and observed three types of CD4 TIL responses when TIL-Bs presented autologous tumor antigens. There were activated responder C

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30

Sotto, Mírian N., T. De Brito, Ana Maria G. Silva, Monica Vidal, and L. G. Martins Castro. "Antigen distribution and antigen-presenting cells in skin biopsies of human chromoblastomycosis." Journal of Cutaneous Pathology 31, no. 1 (2003): 14–18. http://dx.doi.org/10.1046/j.0303-6987.2004.0131.x.

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31

Weber, Frank, Edgar Meinl, Francesca Aloisi, et al. "Human astrocytes are only partially competent antigen presenting cells." Brain 117, no. 1 (1994): 59–69. http://dx.doi.org/10.1093/brain/117.1.59.

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32

Schwab, Nicholas, Anne Waschbisch, Barbara Wrobel, Hanns Lochmüller, Claudia Sommer, and Heinz Wiendl. "Human myoblasts modulate the function of antigen-presenting cells." Journal of Neuroimmunology 200, no. 1-2 (2008): 62–70. http://dx.doi.org/10.1016/j.jneuroim.2008.06.012.

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33

Bufi, Nathalie, Armelle Bohineust, Stéphanie Dogniaux, et al. "Mechanical Characterization of Human Monocyte Derived Antigen Presenting Cells." Biophysical Journal 106, no. 2 (2014): 176a. http://dx.doi.org/10.1016/j.bpj.2013.11.999.

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34

Zimmermannova, Olga, Ilia Kurochkin, Diego S. Cabrera, et al. "Reprogramming Human Cancer Cells into Antigen Presentation." Blood 138, Supplement 1 (2021): 1709. http://dx.doi.org/10.1182/blood-2021-152322.

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Abstract Cancer progression entails close crosstalk between tumor cells and immune system. Recent advances in understanding mutual tumor-immune interactions translated into the development of cancer immunotherapy, changing the cancer treatment paradigm. Nevertheless, despite achieving long-term effect even in advanced malignancies, only a minor subset of patients responds to immunotherapy. The activation of the immune system, as well as good response to the immunotherapy strongly depends on tumor immunogenicity and effective presentation of tumor-associated antigens by conventional dendritic c

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35

Moody, D. Branch, and Sara Suliman. "CD1: From Molecules to Diseases." F1000Research 6 (October 30, 2017): 1909. http://dx.doi.org/10.12688/f1000research.12178.1.

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The human cluster of differentiation (CD)1 system for antigen display is comprised of four types of antigen-presenting molecules, each with a distinct functional niche: CD1a, CD1b, CD1c, and CD1d. Whereas CD1 proteins were thought solely to influence T-cell responses through display of amphipathic lipids, recent studies emphasize the role of direct contacts between the T-cell receptor and CD1 itself. Moving from molecules to diseases, new research approaches emphasize human CD1-transgenic mouse models and the study of human polyclonal T cells in vivo or ex vivo in disease states. Whereas the h

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36

Nizzoli, Giulia, Jana Krietsch, Anja Weick, et al. "Human CD1c+ dendritic cells secrete high levels of IL-12 and potently prime cytotoxic T-cell responses." Blood 122, no. 6 (2013): 932–42. http://dx.doi.org/10.1182/blood-2013-04-495424.

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Key Points CD1c+ DC but not BDCA-3+ DC or other antigen-presenting cells secrete high amounts of bioactive IL-12. CD1c+ DC efficiently cross-present antigens, prime CD8+ T cells, and induce the highest levels of cytotoxic molecules.

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Shaw, Tanya J., Xiang Y. Zhang, Zhiming Huo, et al. "Human Peritoneal Mesothelial Cells Display Phagocytic and Antigen-Presenting Functions to Contribute to Intraperitoneal Immunity." International Journal of Gynecologic Cancer 26, no. 5 (2016): 833–38. http://dx.doi.org/10.1097/igc.0000000000000697.

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AbstractMesothelial cells lining the peritoneal cavity are strategically positioned to respond to and counter intraperitoneal infections, cancer cells, and other challenges. We have investigated human peritoneal mesothelial cells (HPMCs) for phagocytic activity, expression of surface Major Histocompatibility Complex (MHC) class II and accessory molecules involved in antigen presentation, and the ability to present recall antigens to T cells. Phagocytosis of dextran, latex beads, andEscherichia coliwas observed by flow cytometry, and internalization was visualized using confocal and electron mi

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38

Rose, M. L. "Endothelial cells as antigen-presenting cells: role in human transplant rejection." Cellular and Molecular Life Sciences CMLS 54, no. 9 (1998): 965–78. http://dx.doi.org/10.1007/s000180050226.

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39

Ireland, Sara, Alyssa Guzman, Laurie Davis, et al. "B cells from relapsing remitting multiple sclerosis patients modulate T cell behavior in a neuroantigen-specific manner (HUM1P.322)." Journal of Immunology 192, no. 1_Supplement (2014): 52.22. http://dx.doi.org/10.4049/jimmunol.192.supp.52.22.

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Abstract The role of B cells in the pathoetiology of relapsing remitting multiple sclerosis is not well understood. B cells may contribute to MS by antibody secretion, cytokine production and antigen presentation. Antigen-specific B cells are highly efficient antigen presenting cells in the context of their cognate antigens. Since antibodies from multiple sclerosis patients bind to neuroantigens we hypothesized that neuroantigen specific memory B cells promote disease in multiple sclerosis patients by serving as antigen presenting cells for auto-reactive T cells. We observed that B cells from

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40

Siegrist, C. A., E. Martinez-Soria, I. Kern, and B. Mach. "A novel antigen-processing-defective phenotype in major histocompatibility complex class II-positive CIITA transfectants is corrected by interferon-gamma." Journal of Experimental Medicine 182, no. 6 (1995): 1793–99. http://dx.doi.org/10.1084/jem.182.6.1793.

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Presentation of exogenous protein antigens to T lymphocytes is based on the intersection of two complex pathways: (a) synthesis, assembly, and transport of major histocompatibility complex (MHC) class II-invariant chain complexes from the endoplasmic reticulum to a specialized endosomal compartment, and (b) endocytosis, denaturation, and proteolysis of antigens followed by loading of antigenic peptides onto newly synthesized MHC class II molecules. It is believed that expression of MHC class II heterodimers, invariant chain and human leukocyte antigen-DM is both necessary and sufficient to rec

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Hari, Aswin, and Yan Shi. "Plasma membrane interactions that determine presentation of antigens by Antigen-presenting cells. (P5022)." Journal of Immunology 190, no. 1_Supplement (2013): 41.12. http://dx.doi.org/10.4049/jimmunol.190.supp.41.12.

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Abstract Antigen presentation is a critical process in host defense for initiating adaptive immune responses. The APC loads peptides derived from antigens onto major histocompatibility complex (MHC) molecules and exports them to the surface for T cells sampling. If the primary interaction between an APC and T cell is successful, i.e. the TCR binds an appropriate MHC-peptide complex, this leads to an adaptive immune response. Peptide antigens are presented on two types of MHC molecules, MHC I and MHC II via several distinct processing pathways. In turn, the MHC molecule dictates which type of T

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42

Berard, Frederic, Patrick Blanco, Jean Davoust, et al. "Cross-Priming of Naive Cd8 T Cells against Melanoma Antigens Using Dendritic Cells Loaded with Killed Allogeneic Melanoma Cells." Journal of Experimental Medicine 192, no. 11 (2000): 1535–44. http://dx.doi.org/10.1084/jem.192.11.1535.

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The goal of tumor immunotherapy is to elicit immune responses against autologous tumors. It would be highly desirable that such responses include multiple T cell clones against multiple tumor antigens. This could be obtained using the antigen presenting capacity of dendritic cells (DCs) and cross-priming. That is, one could load the DC with tumor lines of any human histocompatibility leukocyte antigen (HLA) type to elicit T cell responses against the autologous tumor. In this study, we show that human DCs derived from monocytes and loaded with killed melanoma cells prime naive CD45RA+CD27+CD8+

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43

Brautbar, C., I. Cohen, L. Sherman, S. More-Yosef, and J. R. Oksenberg. "Induction of T-suppressor cells by human decidual antigen presenting cells primed with fetal antigens." Human Immunology 23, no. 2 (1988): 82. http://dx.doi.org/10.1016/0198-8859(88)90107-3.

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44

Gagliardi, Maria Cristina, Raffaela Teloni, Federico Giannoni, et al. "Mycobacteria Exploit p38 Signaling To Affect CD1 Expression and Lipid Antigen Presentation by Human Dendritic Cells." Infection and Immunity 77, no. 11 (2009): 4947–52. http://dx.doi.org/10.1128/iai.00607-09.

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ABSTRACT Group I CD1 proteins are specialized antigen-presenting molecules that present both microbial and self lipid antigens to CD1-restricted α/β T lymphocytes. The production of high levels of gamma interferon and lysis of infected macrophages by lipid-specific T lymphocytes are believed to play pivotal roles mainly in the defense against mycobacterial infections. We previously demonstrated that Mycobacterium tuberculosis and bacillus Calmette-Guérin (Mycobacterium bovis BCG) induce human monocytes to differentiate into CD1− dendritic cells (DC), which cannot present lipid antigens to spe

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Doe, W., and P. Pavli. "Antigen Presentation in the Gut." Canadian Journal of Gastroenterology 4, no. 7 (1990): 267–70. http://dx.doi.org/10.1155/1990/527602.

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The induction of T cell responses requires recognition of antigens in association with class II major histocompatibility complex (MHC) proteins and specialized antigen-presenting cells. Candidate antigen-presenting cells in the gut include dendritic cells, macrophages, B lymphocytes, mucosal epithelial cells and endothelial cells. Dendritic cells isolated from normal human colon are potent inducers of primary immune responses and express high levels of class lI MHC proteins. Lamina propria macrophages display class II MHC proteins, can present antigens to sensitized T cells, may process antige

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Cohn, Lillian, Bithi Chatterjee, Filipp Esselborn, et al. "Antigen delivery to early endosomes eliminates the superiority of human blood BDCA3+ dendritic cells at cross presentation." Journal of Experimental Medicine 210, no. 5 (2013): 1049–63. http://dx.doi.org/10.1084/jem.20121251.

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Human BDCA3+ dendritic cells (DCs), the proposed equivalent to mouse CD8α+ DCs, are widely thought to cross present antigens on MHC class I (MHCI) molecules more efficiently than other DC populations. If true, it is unclear whether this reflects specialization for cross presentation or a generally enhanced ability to present antigens on MHCI. We compared presentation by BDCA3+ DCs with BDCA1+ DCs using a quantitative approach whereby antigens were targeted to distinct intracellular compartments by receptor-mediated internalization. As expected, BDCA3+ DCs were superior at cross presentation of

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Komohara, Yoshihiro, Toshiki Anami, Kenichi Asano, Yukio Fujiwara, Junji Yatsuda, and Tomomi Kamba. "Anti-Cancer Immune Reaction and Lymph Node Macrophage; A Review from Human and Animal Studies." Immuno 1, no. 3 (2021): 223–30. http://dx.doi.org/10.3390/immuno1030014.

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Lymph nodes are secondary lymphoid organs that appear as bean-like nodules usually <1 cm in size, and they are localized throughout the body. Many antigen-presenting cells such as dendritic cells and macrophages reside in lymph nodes, where they mediate host defense responses against pathogens such as viruses and bacteria. In cancers, antigen-presenting cells induce cytotoxic T lymphocytes (CTLs) to react to cancer cell-derived antigens. Macrophages located in the lymph node sinus are of particular interest in relation to anti-cancer immune responses because many studies using both human sp

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Sallusto, Federica, Chiara Nicolò, Ruggero De Maria, Silvia Corinti, and Roberto Testi. "Ceramide Inhibits Antigen Uptake and Presentation by Dendritic Cells." Journal of Experimental Medicine 184, no. 6 (1996): 2411–16. http://dx.doi.org/10.1084/jem.184.6.2411.

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Ceramides are intramembrane diffusible mediators involved in transducing signals originated from a variety of cell surface receptors. Different adaptive and differentiative cellular responses, including apoptotic cell death, use ceramide-mediated pathways as an essential part of the program. Here, we show that human dendritic cells respond to CD40 ligand, as well as to tumor necrosis factor-α and IL-1β, with intracellular ceramide accumulation, as they are induced to differentiate. Dendritic cells down-modulate their capacity to take up soluble antigens in response to exogenously added or endo

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Vojtech, Lucia N., Sean Hughes, Claire Levy, Alexandria Taber, Fernanda Calienes, and Florian Hladik. "Exosomes in human semen impair antigen-presenting cell function and decrease antigen-specific T cell responses." Journal of Immunology 196, no. 1_Supplement (2016): 136.14. http://dx.doi.org/10.4049/jimmunol.196.supp.136.14.

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Abstract Exposure to semen is the primary route of transmission for many sexually transmitted infections. Accumulating evidence suggests that components in semen directly impair leukocytes, which could compromise the protective efficacy of vaccine-induced immune responses in the mucosa. Exosomes, small microvesicles with immunomodulatory functions, are present at an average concentration of 2.2 × 1013 particles per ejaculate (n = 18). These seminal exosomes (SE) efficiently and rapidly entered peripheral and vaginal dendritic cells (DCs), whereas T cell uptake was poor. In PBMC cultures, SE im

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Wyss-Coray, Tony, Harold Gallati, Inge Pracht, et al. "Antigen-presenting human T cells and antigen-presenting B cells induce a similar cytokine profile in specific T cell clones." European Journal of Immunology 23, no. 12 (1993): 3350–57. http://dx.doi.org/10.1002/eji.1830231243.

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