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Dissertations / Theses on the topic 'Human brain tumor cells'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Landolina, Nadine Anna Caterina. ""Interactions and invasiveness of melanomatous human tumor cells within the blood brain barrier endothelium"." Doctoral thesis, Università di Catania, 2013. http://hdl.handle.net/10761/1397.

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Brain metastases occur in about 25% of patients who die of cancer.One of the most common sources of brain metastases in adults is cutaneous melanoma.The malignant potential of melanomatous cell and its adhesion to the cerebral endothelium plays a key role in this process.The aim of this study was to better characterize the interactions between melanoma cells and the cerebral endothelium, in an attempt to mimick, in some way, melanomatous cells crossing through the BBB and the subsequent spread throghout the cerebral parenchyma.

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2

Pistollato, Francesca. "Oxygen Tension Controls the Expansion and Differentiation of Normal and Tumor-derived Human Neural Stem Cells. Role of oxygen in BMP responsiveness." Doctoral thesis, Università degli studi di Padova, 2007. http://hdl.handle.net/11577/3425173.

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During neural development the generation of diverse cell types involves the response of precursor cells to a wide variety of environmental cues, like soluble factors, the extracellular matrix and oxygen tension. Among these, oxygen tension and oxidation state in particular are important biophysical parameters that control neural precursor proliferation, survival and fate determination, so the dynamic control of oxygen availability regulates self renewal and the generation of cell diversity during development and throughout the life of the organism. However, the mechanisms by which oxygen acts

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3

Lanser, Brittany. "Characterization of checkpoint adaptation in human fibroblastic glioma cells and an analysis of protein phosphatase inhibitors." Thesis, Lethbridge, Alta. : University of Lethbridge, Dept. of Biological Sciences, c2012, 2012. http://hdl.handle.net/10133/3390.

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This thesis reports that checkpoint adaptation occurs in human brain cancer cells. M059K cells, after treatment with camptothecin (CPT), recruited γ-histone H2AX, phosphorylated Chk1 and arrested in the G2 phase. Strikingly, cells escaped the checkpoint, became rounded and entered mitosis as measured by phospho-histone H3 signals. Lamin A/C immunofluorescence microscopy revealed that 48% of the cells that survived checkpoint adaptation contained micronuclei. These data suggest that brain cancer cells undergo checkpoint adaptation and may have an altered genome. This thesis also explored if pho

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4

Geremia, Ezequiel. "Spatial random forests for brain lesions segmentation in MRIs and model-based tumor cell extrapolation." Phd thesis, Université Nice Sophia Antipolis, 2013. http://tel.archives-ouvertes.fr/tel-00838795.

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The large size of the datasets produced by medical imaging protocols contributes to the success of supervised discriminative methods for semantic labelling of images. Our study makes use of a general and efficient emerging framework, discriminative random forests, for the detection of brain lesions in multi-modal magnetic resonance images (MRIs). The contribution is three-fold. First, we focus on segmentation of brain lesions which is an essential task to diagnosis, prognosis and therapy planning. A context-aware random forest is designed for the automatic multi-class segmentation of MS lesion

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5

Letzien, Ulrike. "Effects of Carnosine and L-histidine on Viability and Expression of Pyruvate Dehydrogenase Kinase 4 in Human Glioblastoma Cells." Doctoral thesis, Universitätsbibliothek Leipzig, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-197285.

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Die Arbeit behandelt die Ergebnisse von Experimenten über die Wirkung des Dipeptides Carnosin (β Alanyl L Histidin) und der Aminosäuren L Histidin und β-Alanin auf Kulturen der humanen Zellreihen U87, T98G und LN405, welche von Zellen des malignen Hirntumors Glioblastoma multiforme abgeleitet sind. Die Vitalität der Zellen nach Inkubation mit Carnosin oder L Histidin wurde anhand der Adenosintriphosphatproduktion und der Dehydrohenaseaktivität für Inkubationszeiträume von 24, 48 und 72 Stunden bestimmt. Dabei zeigte sich eine signifikant niedrigere Vitalität der mit Carnosin oder L Histidin

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6

Junnikkala, Sami. "Complement resistance mechanisms of human tumor cells." Helsinki : University of Helsinki, 2002. http://ethesis.helsinki.fi/julkaisut/laa/haart/vk/junnikkala/.

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7

Kaul, Aparna. "Mechanisms of Non-Conventional Cell Death in Brain Tumor Cells." University of Toledo Health Science Campus / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=mco1243364096.

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8

Najim, Nigar. "A study of the cytotoxic effects of methionine depletion in human brain tumour cell lines." Thesis, University of Salford, 2007. http://usir.salford.ac.uk/26832/.

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The aim of this project was to investigate the importance of methionine depletion as a cause of cytotoxicity for paediatric CNS tumour cell lines, and also to investigate the in vitro cellular biochemical responses, as measured by changes in cellular levels of L-methionine, glutathione and O6 - alkylguanine DNA - alkyltransferase (MGMT) activity in glioma (D54) and medulloblastoma (Daoy) cell lines. A characteristic feature of many solid tumours is their requirement for both endogenous and exogenous L-methionine in order to support cellular proliferation. Normal cells are generally methionine-

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9

Curtis, Maurice A. "Neural progenitor cells in the Huntington's Disease human brain." Thesis, University of Auckland, 2004. http://hdl.handle.net/2292/3114.

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The recent demonstration of endogenous progenitor cells in the adult mammalian brain raises the exciting possibility that these undifferentiated cells may be able to generate new neurons for cell replacement in diseases such as Huntington's disease (HD). Previous studies have shown that neural stem cells in the rodent brain subependymal layer (SEL), adjacent to the caudate nucleus, proliferate and differentiate into neurons and glial cells but no previous study has characterised the human SEL or shown neurogenesis in the diseased human brain. In this study, histochemical and immunohistochemica

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10

Carlsten, Mattias. "Molecular specificities of NK cell-mediated recognition of human tumor cells." Stockholm, 2010. http://diss.kib.ki.se/2010/978-91-7409-686-6/.

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11

Bauman, Patricia Ann. "Interactions of mitoxantrone with cytokeratin in human and murine tumor cells." Diss., The University of Arizona, 1993. http://hdl.handle.net/10150/186357.

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The prolonged intracellular retention of the anti-cancer drug mitoxantrone has been linked to its cytotoxicity by several investigators. The persistent association of mitoxantrone with intermediate filament cytokeratin proteins was likewise observed, and its relationship to drug cytotoxicity was investigated. To test whether this association was indicative of mitoxantrone damage to cytokeratin, human WiDr/S colon carcinoma cells or mitoxantrone-resistant WiDr/R cells were treated with mitoxantrone and isolated cytokeratins were examined. Although an affinity of mitoxantrone for cytokeratin pro

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12

Gupta, Kunal. "Using human embryonic stem cells to model acute brain injury." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610468.

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13

Flores, Catherine T. "Characterization of a stem cell population derived from human peripheral blood and its therapeutic potential in brain tumors." Thesis, Imperial College London, 2009. http://hdl.handle.net/10044/1/4349.

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Adherent CD34+ cells are a stem cell enriched population with a high frequency of primitive stem cells that are genetically primed to differentiate into tissue-specific lineages. These cells make up the adherent CD34+ cells in peripheral blood which are the focus of this study. The first aim of this study was to transcriptionally characterize adherent CD34+ cells relative to nonadherent CD34+ cells using a whole human genome Affymetrix U133 plus 2 array. The subsequent analysis demonstrated transcriptional differences in genes which are involved in quiescence, cell cycle, homing and adhesion,

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14

Siesjö, Peter. "Immunotherapy of rat brain tumors with mutagen induced, cross-reactive tumor cell variants." Lund : Section of Tumor Immunology, Dept. of Cell and Molecular Biology, University of Lund, 1997. http://books.google.com/books?id=TXZrAAAAMAAJ.

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15

Anzenberg, Vered. "LET dependence of radiation-induced bystander effects using human prostate tumor cells." Thesis, Massachusetts Institute of Technology, 2008. http://hdl.handle.net/1721.1/44795.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Nuclear Science and Engineering, 2008.<br>"June 2008."<br>Includes bibliographical references (leaves 133-140).<br>In the past fifteen years, evidence provided by many independent research groups have indicated higher numbers of cells exhibiting damage than expected based on the number of cells traversed by the radiation. This phenomenon has been coined as the "bystander effect". The purpose of this study was to characterize the ability of irradiated tumor cells to induce bystander effects in co-cultured cells. Human DU-145 prost

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Dowlatshahi, Mitra. "Suppressed Activity of Tumor-Specific T Cells in Human Merkel Cell Carcinomas." Thesis, Harvard University, 2017. http://nrs.harvard.edu/urn-3:HUL.InstRepos:32676135.

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Merkel cell carcinomas (MCC) are rare but highly malignant skin cancers associated with a novel polyomavirus. We studied T cells in MCC to determine how these virally mediated tumors evade immune responses. MCC tumors were infiltrated by T cells, including effector, central memory and increased numbers of CD4 and CD8 FOXP3+ regulatory T cells. Infiltrating T cells showed markedly reduced activation as evidenced by reduced expression of CD69 and CD25. Treatment of MCC tumors in vitro with IL-2 and IL-15 led to T cell activation, proliferation, enhanced cytokine production and loss of viable tum

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17

Claessens, Antoine. "How Plasmodium falciparum malaria parasites bind to human brain endothelial cells." Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/4897.

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Cerebral malaria is characterised by an accumulation of infected erythrocytes in the microvasculature of the brain. Plasmodium falciparum infected erythrocytes have been shown to bind to a Human Brain Endothelial Cell line (HBEC-5i) in vitro. This provides a model for the investigation of interactions between P. falcuparum and human brain endothelium. Currently neither the parasite adhesion ligands on infected erythrocytes, nor the host endothelial cell receptors necessary for this interaction have been identified. In this work, the identity of the host receptor on brain endothelial cells was

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18

Horiguchi, Satoshi. "Neural precursor cells derived from human embryonic brain retain regional specificity." Kyoto University, 2005. http://hdl.handle.net/2433/144744.

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Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(医学)<br>甲第11420号<br>医博第2843号<br>新制||医||891(附属図書館)<br>23063<br>UT51-2005-D170<br>京都大学大学院医学研究科脳統御医科学系専攻<br>(主査)教授影山龍一郎, 教授大森治紀, 教授金子武嗣<br>学位規則第4条第1項該当

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19

Mao, Jian. "Vesicular stomatitis virus G pseudotyped retrovector mediated gene delivery of connexin43 to brain tumor cells." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0001/MQ42173.pdf.

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20

Rao, Rohit R. "The Microenvironment as a Regulator of Nervous System Development, Brain Tumor Growth and Treatment Resistance." University of Cincinnati / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1624917824334193.

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21

Hemmingsson, Oskar. "ASNA1 and cisplatin resistance : studies in C. elegans and in human tumor cells." Doctoral thesis, Umeå universitet, Kirurgi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-37661.

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Platinum based chemotherapy is widely used to treat cancer. Cisplatin (diamminedichloroplatinum) combination treatments provide cure for metastatic testicular cancer and prolong survival for patients suffering from ovarian, head and neck, bladder and non small cell lung cancer. Tumors that initially respond to treatment may eventually acquire resistance, resulting in treatment failure. Cisplatin resistant cells are crossresistant to arsenite and antimonite and these metalloids are exported from bacteria by the ars-operon. In this thesis, we describe the human ArsA homolog, ASNA1, as a protein

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22

Hill, Andrew A. "Cell cycle-related effects on the radiation survival responses of human tumor cells." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape10/PQDD_0008/NQ38895.pdf.

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23

Wang, Rong Ph D. Massachusetts Institute of Technology. "Direct and indirect effects of alpha-particle irradiations of human prostate tumor cells." Thesis, Massachusetts Institute of Technology, 2005. http://hdl.handle.net/1721.1/34439.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Nuclear Engineering, 2005.<br>"September 2005."<br>Includes bibliographical references.<br>The objective of this project is to establish a model system to study the direct effect, the bystander effect and the combinational effect of alpha-particle irradiations of human prostate tumor cells, toward the goal of improving the effectiveness of alpha-particle involved radiation therapies such as radioimmunotherapy and BNCT. This project consists of an engineering part and a biological part. In the engineering part, an apparatus for al

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24

Fultz, Kimberly Elizabeth. "APC-dependent regulation of polyamine metabolism and apoptosis in human colon tumor cells." Diss., The University of Arizona, 2002. http://hdl.handle.net/10150/280176.

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Mutation/deletion of the adenomatous polyposis coli (APC) tumor suppressor gene in germline cells of rodents and humans is associated with increased intestinal activity of ornithine decarboxylase (ODC), the first enzyme in polyamine synthesis, and intestinal neoplasia. To study the role of APC in signaling ODC expression, the human colon tumor cell line HT29 (wtAPC -/-) was stably transfected with a zinc-inducible wild-type APC gene. Addition of ZnCl2 to HT29-APC cells increased wild-type APC protein and Mad1 RNA and protein, and decreased levels of c-myc and ODC RNA and protein, relative to

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25

Al-sandaqchi, Alaa. "Interaction of Toxoplasma gondii with human brain microvascular endothelial cells in vitro." Thesis, University of Nottingham, 2016. http://eprints.nottingham.ac.uk/37837/.

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Background: The brain is the most commonly affected organ during Toxoplasma gondii infection but the mechanisms utilized by this protozoan parasite for disrupting the brain's endothelial cells lining the blood–brain barrier (BBB) and moving to invade the brain are not yet understood. In the present study, we investigated the cellular pathogenicity of T. gondii infection in human brain microvascular endothelial cells (HBMECs), a fundamental component of the BBB. Methods: Intracellular development of T. gondii tachyzoites within HBMECs was characterized by using Acridine Orange (AO) staining. Th

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26

Taylor, Charles Dariush. "Structural characterisation and analysis of human cripto-1." Thesis, University of Oxford, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.670042.

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27

Wong, Hon-Kit. "Modulation of p21 human tumor suppressor gene expression by zinc status in human hepatoblastoma and normal human bronchial epithelial cells." College Park, Md. : University of Maryland, 2007. http://hdl.handle.net/1903/6877.

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Thesis (Ph. D.) -- University of Maryland, College Park, 2007.<br>Thesis research directed by: Nutrition. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.

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28

Dunne, Amanda Louise. "Cytotoxic effects of radiation and docetaxel in human tumour cells." Thesis, University of Ulster, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.342410.

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29

Basavappa, Srisaila. "Hypoosmotically-activated anion permeability in the human neuroblastoma cell line CHP-100." Thesis, University of Oxford, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.318761.

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30

Bäcklund, Magnus. "The epidemiology, biology and genetics of human astrocytic tumours /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-188-1/.

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31

Loftin, Charles Georgakilas Alexandros. "Repair of Clustered DNA Lesions in Double Strand Break Repair Deficient Human Tumor Cells." [Greenville, N.C.] : East Carolina University, 2010. http://hdl.handle.net/10342/2727.

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32

Mattiola, I. "CROSS-TALK BETWEEN HUMAN NK CELLS AND MACROPHAGES: INFLUENCE OF THE TUMOR MICRO-ENVIRONMENT." Doctoral thesis, Università degli Studi di Milano, 2014. http://hdl.handle.net/2434/229562.

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Natural killer (NK) cells are important effectors of innate immune responses providing cellular immunity against tumor-transformed and virally-infected cells. The existence of cross-talks between NK cells and myeloid cells, in particular dendritic cells, is well established, but information on the cross-talk between NK cells and macrophages is scanty. These interactions have been analyzed using an in vitro reconstituted tumoral micro-environment, as a simplified model to define soluble factors involved and/or cell contact dependency. Autologous human NK cells and monocyte-derived macrophages

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33

Pennucci, Roberta. "CDK5 : new insights into its biological function in human brain microvascular endothelial cells." Thesis, Manchester Metropolitan University, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.496791.

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Ischaemic stroke is a leading cause of death and disability worldwide Successful therapies reside in a precise knowledge of brain function and pathology. Towards this end, previous work in the MMU laboratory used cDNA microarrays to examine gene expression in an experimental rat model of ischaemic stroke - permanent MCAO - and for the first time in human brain tissue from ischaemic stroke patients. Novel deregulated genes were identified. This study was intended to confirm the reproducibility of the in vivo data in vitro. The results showed that human foetal (cerebral cortical) neurons (HFN),

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34

Trillo-Pazos, Gusta. "Toxicity of HIV proteins (NEF, TAT, GP120) and TNFÎ± on human brain cells." Thesis, King's College London (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.341933.

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35

Giguzinsky, Orit. "Environmental and age effects on methylation changes in human brain and blood cells." Thesis, Massachusetts Institute of Technology, 2014. http://hdl.handle.net/1721.1/91823.

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Thesis: M. Eng., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2014.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (pages 125-129).<br>Previous studies have shown that DNA methylation may 1 e associated with disease, aging, the rate of aging and genetics. In this thesis, age is accurately predicted from DNA methylation in brain and blood tissues using two different algorithms, Random Forest and Linear Regression. Relationships between DNA methylation, genetics, disease and aging rate were also identified. Fur

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36

Bhandage, Amol K. "Glutamate and GABA signalling components in the human brain and in immune cells." Doctoral thesis, Uppsala universitet, Fysiologi, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-282422.

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Glutamate and γ-aminobutyric acid (GABA) are the principal excitatory and inhibitory neurotransmitters in the central nervous system (CNS). They both can activate their ionotropic and metabotropic receptors. Glutamate activates ionotropic glutamate receptors (iGlu - AMPA, kainate and NMDA receptors) and GABA activates GABA-A receptors which are modulated by many types of drugs and substances including alcohol. Using real time quantitative polymerase chain reaction, I have shown that iGlu and/or GABA-A receptor subunits were expressed in the hippocampus dentate gyrus (HDG), orbitofrontal cortex

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Pak, Fatemeh. "HHV-8/KSHV association with tumor cells during development of Kaposi sarcoma /." Stockholm, 2006. http://diss.kib.ki.se/2006/20060202pak/.

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38

Ernest, Nola Jean. "The role of chloride in the volume regulation of human glioma cells." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2007. http://www.mhsl.uab.edu/dt/2007p/ernest.pdf.

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39

Mullet, Emily. "Functional Consequences of Matrix Metalloproteinase-1 Over-Expression in Human Gliomas." VCU Scholars Compass, 2006. http://hdl.handle.net/10156/1437.

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Jezierski, Anna. "Characterization and Therapeutic Potential of Human Amniotic Fluid Cells in Mediating Neuroprotection." Thèse, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/26157.

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Brain injury, either surgically induced or as a result of trauma or stroke, is one of the leading causes of death and disability worldwide. Since transplantable stem cell sources are showing a great deal of promise and are actively being pursued to provide neuroprotection post-injury, in this body of work, we set out to characterize and examine the therapeutic potential of amniotic fluid derived (AF) cells as a potential cell source for cell-based therapies in mediating neuroprotection post-injury. Despite their heterogeneity, we found that AF cells are mainly epithelial in origin and express

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41

WU, HUI-CHUN, and 吳蕙君. "Autophagy inducers modulated ATG4B expression in human brain tumor cells." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/25u9d3.

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碩士<br>國立中山大學<br>生物科學系研究所<br>106<br>Autophagy is a self-eating mechanism in cells through which damaged proteins and organelles are recruited to autophagosomes and fused with lysosome for their bulk degradation and recycling during nutrient deprivation. Dysregulation of autophagy is associated with various diseases, including cancer. ATG4B is a cysteine protease required for autophagy machinery. Recent reports have shown that elevated ATG4B promoted tumorigenesis, malignancy and drug resistance, suggesting ATG4B might modulate autophagy to facilitate tumor progression. However, the role of auto

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Chang, Yu-Chien, and 張雨倩. "Immunosuppressive effects of human malignant brain tumor cells on immune lymphocyte in vitro." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/77625906436279020465.

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碩士<br>中國醫藥大學<br>醫學研究所碩士班<br>94<br>Malignant tumors, including childhood neuroblastoma and adult glioblastoma multiforme (GBM), are among the most fatal human cancer diseases. In search for novel cancer treatment measures, immuno-therapeutic strategies have recently attracted considerable interest. However, patients of malignant brain tumors may show immune dysfunction. The goal of this study is to investigate the immuno-suppressive effects of brain tumor cells in vitro. Peripheral blood T lymphocytes of healthy donors or GBM patients were labeled with 5-(and-6) carboxyfluorescein diacetate suc

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Chen, Hui-Jung, and 陳惠蓉. "Effect of EGCG on proliferation inhibition and apoptotic mechanism of human brain tumor cells." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/94777922861873181664.

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碩士<br>國立中山大學<br>生物科學系研究所<br>93<br>Cancer has become the major factor causing death in Taiwan. Although brain tumor take a few ratio in cancer, the current therapy shown not effect well. In previous studies, EGCG will promote cancer cells to go apoptosis after treatment with EGCG. But the mechanism in brain tumor is unknown. So, we use EGCG from green tea extract to investigate cell death of human brain tumor cell lines GBM8401, U87MG and U251. The metabolic rates of GBM8401, U87 and U251 are decrease with EGCG treatment, and it is significant in GBM8401. We also examine some genes and proteins

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Brandon, Caroline. "Wnt Signaling in Human Neural Stem Cells and Brain Tumour Stem Cells." Thesis, 2010. http://hdl.handle.net/1807/25435.

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We sought to determine whether activation of the Wnt signaling pathway altered the function of hNSCs in vitro. We took three approaches to activate Wnt signaling: Wnt3a, constitutively stabilized β-catenin (ΔN90), and the GSK3 inhibitor BIO. While Wnt3a and ΔN90 had no effect on proliferation in both stem cell (+EGF/FGF) and differentiating (-EGF/FGF) conditions, BIO reduced proliferation in both. All methods of Wnt signaling activation promoted neuronal lineage commitment during hNSC differentiation. Furthermore, BIO was able to induce mild neuronal differentiation in stem cell conditions, su

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Chu, Jao-Jia, and 朱兆嘉. "The Effect of Paclitaxel on Protein Phosphorylation and Reorganization of Intermediate Filaments in Rat Brain Tumor Cells and Human Non-small Cell Lung Cancer Cells." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/46991103396193447955.

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博士<br>國立清華大學<br>生命科學系<br>93<br>we report that taxol induces hyperphosphorylation and reorganization of the vimentin intermediate filament in 9L rat brain tumor cells, in concentration- and time-dependent manner. Phosphorylation of vimentin was maximum at10-6 M of taxol treatment for 8 h and diminished at higher (10-5 M) concentration. Enhanced phosphorylation of vimentin was detectable at 2 h treatment with 10-6 M taxol and was maximum after 12 h of treatment. Taxol-induced phosphorylation of vimentin was largely abolished in cells pretreated with staurosporine and bisindolymaleimide but was u

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Yueh, Kuo-Chu, and 樂國柱. "The Mechanism Study of Multi-Drug Resistance (MDR) in Human Brain Malignant Tumor Cell Lines." Thesis, 1997. http://ndltd.ncl.edu.tw/handle/69073080952519430133.

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碩士<br>國防醫學院<br>病理及寄生蟲學研究所<br>85<br>Glioblastoma multiforme (GBM), a high-grade malignant brain tumor, has less than 10% of two-year survival rate. It owns a poor prognosis by current surgery, radiotherapy or chemotherapy, so it is important to find new therapy methods to cope with this malignancy. The purpose of this study is to investigate the possible mechanisms of Multi-Drug Resistance (MDR) of primary brain tumors by measurement of cellular P-glycoprotein, lung resistance-related protein (LRP), multidrug resistance-associated protein (MRP), DNA topoisomerase II (Topo II), glutathion S-tr

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"Microarray and biochemical analysis of lovastatin-induced apoptosis in human glioblastoma cells: synergism with TRAIL." 2006. http://library.cuhk.edu.hk/record=b5893069.

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Chan Yiu Leung.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2006.<br>Includes bibliographical references (leaves 123-149).<br>Abstracts in English and Chinese.<br>Abstracts --- p.I<br>Acknowledgements --- p.VIII<br>List of Figures --- p.IX<br>Lists of Abbreviations --- p.X<br>Contents --- p.XII<br>Chapter Chapter One: --- Introduction and Literature Review --- p.1<br>Chapter 1.1 --- Cancer in General --- p.1<br>Chapter 1.2 --- Glioma --- p.3<br>Chapter 1.2.1 --- Types of Glioma --- p.6<br>Chapter 1.2.1.1 --- Astrocytomas --- p.6<br>Chapter 1.2.1.2 --- Oligodendrogliomas ---

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48

Barrantes-Freer, Alonso. "Functional properties of the plasma membrane of human glioma initiating cells." Doctoral thesis, 2012. http://hdl.handle.net/11858/00-1735-0000-000D-F0B9-D.

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49

Letzien, Ulrike. "Effects of Carnosine and L-histidine on Viability and Expression of Pyruvate Dehydrogenase Kinase 4 in Human Glioblastoma Cells." Doctoral thesis, 2015. https://ul.qucosa.de/id/qucosa%3A14489.

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Die Arbeit behandelt die Ergebnisse von Experimenten über die Wirkung des Dipeptides Carnosin (β Alanyl L Histidin) und der Aminosäuren L Histidin und β-Alanin auf Kulturen der humanen Zellreihen U87, T98G und LN405, welche von Zellen des malignen Hirntumors Glioblastoma multiforme abgeleitet sind. Die Vitalität der Zellen nach Inkubation mit Carnosin oder L Histidin wurde anhand der Adenosintriphosphatproduktion und der Dehydrohenaseaktivität für Inkubationszeiträume von 24, 48 und 72 Stunden bestimmt. Dabei zeigte sich eine signifikant niedrigere Vitalität der mit Carnosin oder L Histidin

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50

Huang, Hsuanfei. "The Investigation on the Interaction among Anti-tumor Compounds derived from Adlay Bran against Human Lung and Colorectal Cancer Cells using Combination Index Methodology." 2007. http://www.cetd.com.tw/ec/thesisdetail.aspx?etdun=U0001-2607200713581900.

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