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Journal articles on the topic 'Human cervix adenocarcinoma'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Pirog, Edyta Catalina. "Primary Adenocarcinoma of the Uterine Cervix: Classification and Grading." AJSP: Reviews and Reports 23, no. 2 (2018): 62–72. http://dx.doi.org/10.1097/pcr.0000000000000232.

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Abstract Cervical adenocarcinomas are a group of malignancies with several distinct histologic tumor types, which include endocervical usual type, endometrioid, intestinal, villoglandular, gastric, signet ring, serous, clear cell, and mesonephric. Diagnosis of cervical adenocarcinoma, in particular early diagnosis, and classification of the tumor type may pose a significant challenge. The goal of this article is to review the current classification, diagnostic criteria, adjunct markers, and differential diagnosis of various subtypes of cervical adenocarcinomas. The article presents up-to-date

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2

Djordjevic, Bojana, Aurelia Busca, and Carlos Parra-Herran. "Metastatic Adenocarcinoma to the Uterine Cervix Versus Primary Cervical Adenocarcinoma." AJSP: Reviews and Reports 23, no. 2 (2018): 91–98. http://dx.doi.org/10.1097/pcr.0000000000000234.

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Abstract Adenocarcinoma metastases to the cervix can originate from the endometrium, the upper müllerian tract, or from extramüllerian sites such as the gastrointestinal and pancreatobiliary tract, bladder, breast, lung, or even the salivary gland. In some cases, the metastatic lesions have signet-ring morphology, infiltrative pattern, and/or extensive lymphovascular spread. In others, however, the distinction between a primary cervical lesion and a metastasis to the cervix is more challenging because metastases may mimic endocervical adenocarcinoma in situ by colonizing the native endocervica

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3

Wilczynski, Sharon P., Joan Walker, Shu-Yuan Liao, Suzanne Bergen, and Michael Berman. "Adenocarcinoma of the cervix associated with human papillomavirus." Cancer 62, no. 7 (1988): 1331–36. http://dx.doi.org/10.1002/1097-0142(19881001)62:7<1331::aid-cncr2820620715>3.0.co;2-u.

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4

Harjanto, Budi, and Suhatno Suhatno. "The role of human papillomavirus deoxyribonucleic acid for distinguishing between cervical adenocarcinoma and endometrial adenocarcinoma." Majalah Obstetri & Ginekologi 29, no. 2 (2021): 53. http://dx.doi.org/10.20473/mog.v29i22021.53-56.

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HIGHLIGHTS1. Determining primary tumor between uterine cervical adenocarcinoma and endometrial carcinoma is often complicated due to the lack of specimen or overlapped histological and morphological spectrum.2. The distinction between endometrial and endocervical adenocarcinoma preoperatively is important because the treatment is different.3. The samples from each group are tested for HPV DNA using PCR method.4. High risk HPV infected patients have a higher probability to become uterine cervical adenocarcinoma.5. HPV DNA test has a role for distinguishing between uterine cervical adenocarcinom

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Chew, G. K., M. E. Cruickshank, P. H. Rooney, I. D. Miller, D. E. Parkin, and G. I. Murray. "Human papillomavirus 16 infection in adenocarcinoma of the cervix." British Journal of Cancer 93, no. 11 (2005): 1301–4. http://dx.doi.org/10.1038/sj.bjc.6602855.

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6

Bujor, Iuliana Elena, Ludmila Lozneanu, Alexandra Ursache, et al. "Primary Clear Cell Adenocarcinoma of the Uterine Cervix in a 14-Year-Old Virgin Girl: Case Report." International Journal of Environmental Research and Public Health 19, no. 24 (2022): 16652. http://dx.doi.org/10.3390/ijerph192416652.

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Cervical cancer is rare in adolescent and pediatric populations, with adenocarcinoma being the most commonly reported. Clear cell adenocarcinoma of the uterine cervix accounts for only 4% of all adenocarcinoma cases, and about two-thirds are associated with intrauterine diethylstilbestrol (DES) exposure. We report the case of a 14-year-old virgin girl who presented with a 1-month-long history of abnormal vaginal bleeding and lower abdominal pain. Transabdominal pelvic ultrasound examination revealed the presence of an irregular, homogeneous cervical mass that was 7 cm in size. Therefore, a mag

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ANDERSSON, S., A. C. HELLSTRÖM, T. ÅNGSTRÖM, U. STENDAHL, G. AUER та K. L. WALLIN. "The clinicopathologic significance of laminin-5 γ2 chain expression in cervical squamous carcinoma and adenocarcinoma". International Journal of Gynecologic Cancer 15, № 6 (2005): 1065–72. http://dx.doi.org/10.1136/ijgc-00009577-200511000-00009.

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Carcinoma of the uterine cervix is one of the most prevalent malignancies among women in developing countries and the third most common type worldwide. Squamous cell carcinoma predominates in the cervix uteri, while adenocarcinoma and adenosquamous carcinomas represent about 10–15% of all cervical cancers. Many studies have confirmed that the human papillomavirus (HPV) is the most important etiologic factor in the development of cervical cancer. The aim of our study was to investigate the expression of the laminin-5 γ2 chain in primary malignancies of the cervix uteri and to focus on the clini

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8

Grigoruk, Ol’ga G., Москвина A. Moskvina, Larisa M. Bazulina, Sergej Ju Bakharev, Elena Je Pupkova, and Svetlana A. Elchaninova. "Difficulties and possibilities of cytodiagnosis of origin of adenocarcinoma in cervical smears." Russian Journal of Oncology 27, no. 2 (2023): 71–81. http://dx.doi.org/10.17816/onco197194.

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BACKGROUND: The duration and accuracy of verification of origin and morphological variant of adenocarcinoma in the cervical smear affect the effectiveness of the treatment of patients. Currently, few publications on the possibility of clarifying the origin of adenocarcinoma in a cervical smear using the traditional cytological method are not sufficient for evidence-based conclusions. AIMS: To identify patterns of cytological indicators of origin of adenocarcinoma in the biomaterial from the cervix. MATERIALS AND METHODS: In an observational one-stage retrospective study, a comparat

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9

Kim, Ha-Jeong, Ji-Hee Sung, Eunjung Lee, et al. "Prognostic Factors Influencing Decisions About Surgical Treatment of Villoglandular Adenocarcinoma of the Uterine Cervix." International Journal of Gynecologic Cancer 24, no. 7 (2014): 1299–305. http://dx.doi.org/10.1097/igc.0000000000000197.

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ObjectiveThe objectives of this study were to analyze the clinicopathologic features of villoglandular adenocarcinoma (VGA) of the uterine cervix, a variant of cervical adenocarcinoma with good prognosis, and to discuss the association of human papillomavirus (HPV) infection with VGA.MethodsA retrospective review of medical records was performed to identify the patients with VGA between 1999 and 2007 at the Samsung Medical Center.ResultsFifteen patients were identified among 171 women diagnosed with adenocarcinoma of the cervix. The median age was 40 years (range, 32–72 years). Four patients w

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10

Fujiwara, Hiroyuki, Harushige Yokota, Bradley Monk, et al. "Gynecologic Cancer InterGroup (GCIG) Consensus Review for Cervical Adenocarcinoma." International Journal of Gynecologic Cancer 24, Supp 3 (2014): S96—S101. http://dx.doi.org/10.1097/igc.0000000000000263.

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Cervical adenocarcinoma is known to be less common than squamous cell carcinoma of the cervix comprising approximately 25% of all cervical carcinomas. Differences in associated human papillomavirus types, patterns of spread, and prognosis call for treatments that are not always like those for squamous cancers. In this review, we report a consensus developed by the Gynecologic Cancer InterGroup surrounding cervical adenocarcinoma for epidemiology, pathology, treatment, and unanswered questions. Prospective clinical trials are needed to help develop treatment guidelines.Key pointsDifferences bet

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11

Harrison, Beth T., and Marisa R. Nucci. "Glandular Pseudoneoplasms of the Uterine Cervix." AJSP: Reviews and Reports 23, no. 2 (2018): 73–83. http://dx.doi.org/10.1097/pcr.0000000000000237.

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Abstract Several benign glandular lesions of the uterine cervix can mimic malignancy. These glandular pseudoneoplasms include microglandular hyperplasia, lobular and diffuse laminar types of endocervical glandular hyperplasia, tunnel clusters, adenomyoma of endocervical type, mesonephric hyperplasia, ectopic prostate, endometriosis and tuboendometrioid metaplasia, and the Arias-Stella reaction, among others. Each of these entities may show a variety of unusual morphologic features that complicate the diagnosis. This review covers the clinical and pathologic features of this selected group of g

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12

Partha Sarathi Mitra, Medhatithi Barman, Pramit Goswami, Jayita Saha, and Debjit Saha. "Correlation of cervical cancers with long-term use of hormonal oral contraceptive pills - A retrospective observational multicentric study in suburban-based medical colleges in West Bengal." Asian Journal of Medical Sciences 14, no. 12 (2023): 99–105. https://doi.org/10.71152/ajms.v14i12.3387.

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Background: Hormonal oral contraceptive pills (OCP) may increase the risk of carcinoma cervix by changing the susceptibility of cervical cells to persistent infection with high-risk human papilloma virus. There is a causal and promoting association with long-term use of these pills for more than 5 years of use, and the association is diminished 10 years after last use. Aims and Objectives: In this study, retrospective data were collected to analyze the risk of association of carcinoma cervix with hormonal contraceptive pill use. Materials and Methods: Interview-based retrospective observationa

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Partha Sarathi Mitra, Medhatithi Barman, Pramit Goswami, Jayita Saha, and Debjit Saha. "Correlation of cervical cancers with long-term use of hormonal oral contraceptive pills - A retrospective observational multicentric study in suburban-based medical colleges in West Bengal." Asian Journal of Medical Sciences 14, no. 12 (2023): 99–105. http://dx.doi.org/10.3126/ajms.v14i12.58493.

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Background: Hormonal oral contraceptive pills (OCP) may increase the risk of carcinoma cervix by changing the susceptibility of cervical cells to persistent infection with high-risk human papilloma virus. There is a causal and promoting association with long-term use of these pills for more than 5 years of use, and the association is diminished 10 years after last use. Aims and Objectives: In this study, retrospective data were collected to analyze the risk of association of carcinoma cervix with hormonal contraceptive pill use. Materials and Methods: Interview-based retrospective observationa

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14

Costa, Telma Maria Lubambo, Sandra Heráclio, Melania Maria Ramos Amorim, et al. "Human papillomavirus and risk factors for cervical adenocarcinoma in the state of Pernambuco, Brazil." Revista Brasileira de Saúde Materno Infantil 19, no. 3 (2019): 641–49. http://dx.doi.org/10.1590/1806-93042019000300009.

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Abstract Objectives: to determine the incidence of the main high oncogenic risk types of the human papillomavirus (HPV) ( 16, 18, 31 and 33) and the risk factors for cervical adenocarcinoma. Methods: a case-control study was carried out with 324 women (69 with adenocarcinoma and 260 healthy controls) between 2001 and 2014. Information on risk factors associated with adenocarcinomawere collected and the detection performed on HPVby using Polymerase Chain Reaction (PCR) method. Results: adenocarcinoma was associated with age ≥40 years old (OR=2.95; 95%CI=1.13-7.71), ≤3 years of schooling (OR=2.3

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15

Miller, Ross A., Dina R. Mody, Kimberlee C. Tams, and Michael J. Thrall. "Glandular Lesions of the Cervix in Clinical Practice: A Cytology, Histology, and Human Papillomavirus Correlation Study From 2 Institutions." Archives of Pathology & Laboratory Medicine 139, no. 11 (2015): 1431–36. http://dx.doi.org/10.5858/arpa.2014-0633-oa.

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ContextThe Papanicolaou (Pap) test has indisputably decreased cervical cancer mortality, as rates have declined by up to 80% in the United States since its implementation. However, the Pap test is considered less sensitive for detecting glandular lesions than for detecting those of squamous origin. Some studies have even suggested an increasing incidence of cervical adenocarcinoma, which may be a consequence of a relatively reduced ability to detect glandular lesions with cervical cancer screening techniques.ObjectiveTo evaluate the detection rate of glandular lesions with screening techniques

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Leminen, Arto, Jorma Paavonen, Ervo Vesterinen, Torsten Wahlstrom, Immo Rantala, and Matti Lehtinen. "Human Papillomavirus Types 16 and 18 in Adenocarcinoma of the Uterine Cervix." American Journal of Clinical Pathology 95, no. 5 (1991): 647–52. http://dx.doi.org/10.1093/ajcp/95.5.647.

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17

Hørding, Ulla, Christence Stubbe Teglbjærg, Jakob Visfeldt, and Johannes E. Bock. "Human papillomavirus types 16 and 18 in adenocarcinoma of the uterine cervix." Gynecologic Oncology 46, no. 3 (1992): 313–16. http://dx.doi.org/10.1016/0090-8258(92)90223-6.

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18

Togami, Shinichi, Yuko Sasajima, Takahiro Kasamatsu, et al. "Immunophenotype and Human Papillomavirus Status of Serous Adenocarcinoma of the Uterine Cervix." Pathology & Oncology Research 21, no. 2 (2014): 487–94. http://dx.doi.org/10.1007/s12253-014-9854-y.

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19

Kim, Jisup, Sungsoo Lee, and Heae Surng Park. "Metastatic Endobronchial Adenocarcinoma from the Uterine Cervix Verified by Human Papillomavirus Genotyping." Journal of Pathology and Translational Medicine 49, no. 2 (2015): 174–76. http://dx.doi.org/10.4132/jptm.2015.02.10.

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20

Aakash, Nfn, Albina Murzabdillaeva, Mei Lin, and Songlin Zhang. "Endocervical Adenocarcinoma With Skip Lesion in a Fundal Endometrial Polyp Mimicking Endometrioid Adenocarcinoma Arising From Endometrial Polyp." American Journal of Clinical Pathology 152, Supplement_1 (2019): S38—S39. http://dx.doi.org/10.1093/ajcp/aqz113.004.

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Abstract Human papillomavirus–related adenocarcinomas account for approximately 20% of all cervical cancers. Most of them arise in the transformation zone but may be found exclusively in endocervical canal. Contiguous spread into the lower uterine segment is known to occur, but finding a “skip” lesion in a fundal endometrial polyp poses an interesting pathologic conundrum. We present a case of a 57-year-old woman with a history of postcoital bleeding and abnormal cervical smear. Cervical exam showed a 2-cm exophytic mass on anterior cervix. Biopsy revealed invasive endocervical adenocarcinoma.

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21

Kovács, Adriána, Andrea Vasas, Peter Forgo, Borbála Réthy, István Zupkó, and Judit Hohmann. "Xanthanolides with Antitumour Activity from Xanthium italicum." Zeitschrift für Naturforschung C 64, no. 5-6 (2009): 343–49. http://dx.doi.org/10.1515/znc-2009-5-607.

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1Bioassay-guided fractionation of a CHCl3 extract of the leaves of Xanthium italicum Moretti led to the isolation of four xanthanolides: xanthatin (), 4-epixanthanol (2), 4-epiisoxanthanol (3), and 2-hydroxyxanthinosin (4). Their structures were determined by means of 1D and 2D NMR spectroscopy, including 1H-1H COSY, NOESY, HSQC and HMBC experiments, which resulted in complete and unambiguous 1H and 13C NMR chemical shift assignments. The isolated compounds 1 - 4 were evaluated for their antiproliferative activities, and were demonstrated to exert significant cell growth inhibitory activity ag

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22

Tambur, Zoran, Irina Besu-Žižak, Željko Žižak, Anica Joksić, Dolores Opačić, and Vladimir Biočanin. "ANTIPROLIFERATIVE EFFECT OF SPILANTHES ACMELLA EXTRACTS ON HUMAN CERVIX ADENOCARCINOMA AND HUMAN MYELOGENOUS LEUKEMIA CELLS." Acta Veterinaria 74, no. 4 (2025): 538–45. https://doi.org/10.2478/acve-2024-0037.

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Abstract Reactive oxygen and nitrogen species (RONS) play a crucial role in the pathogenesis of various chronic diseases, including cancer, by reacting with fundamental biomolecules. While conventional anticancer treatments such as ionizing radiation and chemotherapy have significant adverse effects, some medicinal plants exhibit free radical scavenging and anticancer activities. Spilanthes acmella L., commonly known as the toothache plant, is reported to have various bioactive compounds with antioxidant and anticancer properties. The aim of this study was to investigate and evaluate antiproli

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23

Umumararungu, T., M. Isaacs, H. Hoppe, E. Goosen, and S. Khanye. "Re-screening and preliminary in vitro evaluation of resorcinol based Hsp90 inhibitors for potential protocidal activity." South African Journal of Chemistry 77 (2023): 24–29. http://dx.doi.org/10.17159/0379-4350/2023/v77a04.

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This study explored a series of resorcinol derivatives originally identified as heat shock protein 90 inhibitors for activity against protozoan parasites. The repurposing of this series revealed that some of these compounds are active against chloroquine-sensitive Plasmodium falciparum (3D7) and Trypanosoma brucei brucei strains with IC50 values below 10 μM without obvious cytotoxic effects against human cervix adenocarcinoma (HeLa) cells at 25 μM.

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Miklášová, Natalia, Peter Herich, Juan Carlos Dávila-Becerril, et al. "Evaluation of Antiproliferative Palladium(II) Complexes of Synthetic Bisdemethoxycurcumin towards In Vitro Cytotoxicity and Molecular Docking on DNA Sequence." Molecules 26, no. 14 (2021): 4369. http://dx.doi.org/10.3390/molecules26144369.

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Metallodrugs form a large family of therapeutic agents against cancer, among which is cisplatin, a paradigmatic member. Therapeutic resistance and undesired side effects to Pt(II) related drugs, prompts research on different metal–ligand combinations with potentially enhanced biological activity. We present the synthesis and biological tests of novel palladium(II) complexes containing bisdemethoxycurcumin (BDMC) 1 and 2. Complexes were fully characterized and their structures were determined by X-ray diffraction. Their biological activity was assessed for several selected human tumor cell line

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Monica, G., and Jemma Hermelin Jesy Diaz. "Anticancer Activity of Zinc Oxide Nanoparticles from the Ink of Uroteuthis Duvaucelii on HeLa (Human Cervix Adenocarcinoma Cell Line) Cells." Indian Journal Of Science And Technology 17, no. 33 (2024): 3437–41. http://dx.doi.org/10.17485/ijst/v17i33.2100.

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Objectives : The present study was carried out to assess the anticancer activity of zinc oxide nanoparticles synthesized from the ink of U. duvaucelii for cell proliferation and cytotoxicity on HeLa (Human cervix adenocarcinoma cell line) cells. Methods : MTT Assay was carried out to evaluate the anticancer activity of zinc oxide nanoparticles from the ink of Uroteuthis duvaucelii. Findings : The zinc-oxide nanoparticles had significant cytotoxicity on HeLa cells in different concentrations (25, 50, 100, 200, 500 µg/ml). A maximum of 37% toxicity was observed at 500µg/ml and a minimum of 1% at

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Farnsworth, Annabelle, Colin Laverty, and Mark H. Stoler. "Human Papillomavirus Messenger RNA Expression in Adenocarcinoma In Situ of the Uterine Cervix." International Journal of Gynecological Pathology 8, no. 4 (1989): 321–30. http://dx.doi.org/10.1097/00004347-198912000-00003.

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27

Teixeira, Julio Cesar, Sophie Françoise Mauricette Derchain, Eliane R. Zambelli Oliveira, et al. "Microinvasive Adenocarcinoma of the Cervix in a Young Woman Vaccinated Against Human Papillomavirus." Journal of Lower Genital Tract Disease 18, no. 2 (2014): E50—E54. http://dx.doi.org/10.1097/lgt.0b013e31829ee5df.

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Fushiki, Hiroshi, Masaki Fujimura, and Rikuichi Izumi. "Evaluation of paclitaxel against human adenocarcinoma of the uterine cervix in nude mice." International Journal of Clinical Oncology 2, no. 3 (1997): 152–55. http://dx.doi.org/10.1007/bf02490126.

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Das, B. C., V. Gopalkrishna, D. K. Das, J. K. Sharma, V. Singh, and Usha K. Luthra. "Human papillomavirus DNA sequences in adenocarcinoma of the uterine cervix in Indian women." Cancer 72, no. 1 (1993): 147–53. http://dx.doi.org/10.1002/1097-0142(19930701)72:1<147::aid-cncr2820720128>3.0.co;2-7.

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30

Fitriyani, Hilda, Delyuzar, and Hidayat. "Identification of CYP1A1 Gene Polymorphism in Squamous Cell Carcinoma and Cervical Adenocarcinoma." Majalah Patologi Indonesia 29, no. 2 (2020): 65–70. http://dx.doi.org/10.55816/mpi.v29i2.410.

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BackgroundCervical cancer is the third most common cancer in women with risk factor of smoking, high parity, long term use of oralcontaception that are associated with chemical carcinogenesis. Chemical carcinogenesis require biotransfor-mation of lipophilicsubstrates to hydrophilic metabolites, therefore facilitating their secretion from the human body. Cytochrome P450 (CYP) is one ofgenes that have important role in this process. Benzo[α]pyrene and estrogen have a common biotransformation process which ismetabolized by CYP, particularly CYP1A1. The objectives to identify the frequency and dis

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Alexandru, Maria-Gabriela, Tanja Velickovic, Ioana Jitaru, Sanja Grguric-Sipka, and Constantin Draghici. "Synthesis, characterization and antitumor activity of Cu(II), Co(II), Zn(II) and Mn(II) complex compounds with aminothiazole acetate derivative." Open Chemistry 8, no. 3 (2010): 639–45. http://dx.doi.org/10.2478/s11532-010-0022-2.

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AbstractThis paper presents the synthesis of complex compounds of type [M(L1)2], where M(II)= Cu (1), Co (2), Zn (3), L1=2-aminothiazole-4-acetate and [Mn(L1)2(H2O)] (4) using ethyl 2-(2-aminothiazole-4-yl) acetate (L), and characterization by elemental analysis, magnetic susceptibilities, IR, 1H-NMR, UV-Vis spectroscopy and for [Mn(L1)2(H2O)] also by X-ray diffraction. In vitro cytotoxicity studies were performed on human cervix adenocarcinoma, HeLa cells. The antitumor selectivity was assessed using normal human peripheral blood mononuclear cells, PBMC as control.

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Li, Feng, Suresh Awale, Yasuhiro Tezuka, and Shigetoshi Kadota. "Cytotoxicity of Constituents from Mexican Propolis against a Panel of Six Different Cancer Cell Lines." Natural Product Communications 5, no. 10 (2010): 1934578X1000501. http://dx.doi.org/10.1177/1934578x1000501018.

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The cytotoxicity of 39 compounds, including eighteen flavonoids (flavanones, 1–10; flavones, 11–17; flavanol, 18), sixteen phenolic acid derivatives (aromatic acids, 19–24; aldehyde, 25; esters, 26–34) and five glycerides (35–39), isolated from Mexican propolis, were evaluated against a panel of six different cancer cell lines; murine colon 26-L5 carcinoma, murine B16-BL6 melanoma, murine Lewis lung carcinoma, human lung A549 adenocarcinoma, human cervix HeLa adenocarcinoma and human HT-1080 fibrosarcoma. A phenylpropanoid-substituted flavanol, (2 R,3 S)-8-[4-phenylprop-2-en-1-one]-4’,7-dihydr

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Hull, A., and T. Guo. "HPV-Independent Cervical Adenocarcinoma Discovered by Cytology-Based Screening: A case report of gastric type adenocarcinoma of the uterine cervix from cytopathology to histopathology." American Journal of Clinical Pathology 162, Supplement_1 (2024): S25—S26. http://dx.doi.org/10.1093/ajcp/aqae129.056.

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Abstract Introduction/Objective In recent years, the relative prevalence of adenocarcinoma has increased, comprising 20–25% of all cervical carcinomas in developed countries. Approximately 15% of cervical adenocarcinomas are unrelated to human papilloma virus (HPV) infection. With the shift toward HPV primary testing, an increased understanding of HPV-independent cervical adenocarcinomas becomes more important. Methods/Case Report This case report demonstrates a rare case of gastric-type adenocarcinoma (GAS) of the cervix discovered during a routine well-woman exam. Patient-reported episodes o

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Shrestha, Agya, Samriddhi Karki, and Deepa Chudal. "Glassy cell carcinoma of cervix: A case report." Indian Journal of Obstetrics and Gynecology Research 8, no. 3 (2021): 428–30. http://dx.doi.org/10.18231/j.ijogr.2021.089.

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Glassy cell carcinoma of the cervix is a rare subtype of adenosquamous carcinoma associated with aggressive course and poor prognosis. It is considered to originate from the subcylindrical reserve cells of the cervix and has been associated with human papillomavirus. Histologically glassy cell carcinoma is composed of nestes of large cells with ground glass cytoplasm and large vesicular nuclei with prominent nucleoli. Nuclear pleomorphism and tumor giant cells are frequently seen. Mitotic activity is brisk. Infiltration by eosinophils and plasma cells with admixture of lymphocytes is a charact

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Park, Kay J. "Case Review: Gastric-Type Adenocarcinoma of the Uterine Cervix and Precursor Lesions." AJSP: Reviews and Reports 23, no. 2 (2018): 84–90. http://dx.doi.org/10.1097/pcr.0000000000000233.

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Abstract A case of gastric-type endocervical adenocarcinoma that was originally diagnosed as possibly of endometrial or pancreatobiliary/upper gastrointestinal tract origin is reported. This report reviews the pertinent medical literature, differential diagnoses, etiology, and pitfalls of this disease, as well as use of immunohistochemistry and human papillomavirus (HPV) testing in establishing the diagnosis. The morphology of these tumors can range from extremely well differentiated (minimal deviation adenocarcinoma) to poorly differentiated, and therefore, the differential diagnosis can be q

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Tase, Toru, Takashi Okagaki, Barbara A. Clark, Leo B. Twiggs, Ronald S. Ostrow, and Anthony J. Faras. "Human Papillomavirus DNA in Adenocarcinoma In Situ, Microinvasive Adenocarcinoma of the Uterine Cervix, and Coexisting Cervical Squamous Intraepithelial Neoplasia." International Journal of Gynecological Pathology 8, no. 1 (1989): 8–17. http://dx.doi.org/10.1097/00004347-198903000-00002.

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Lee, Eun-Ju, Michael McClelland, Yipeng Wang, Fred Long, Sang-Ho Choi, and Je-Ho Lee. "Distinct DNA Methylation Profiles Between Adenocarcinoma and Squamous Cell Carcinoma of Human Uterine Cervix." Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics 18, no. 9 (2009): 401–8. http://dx.doi.org/10.3727/096504010x12644422320744.

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Tambur, Zoran, Irina Besu Žižak, Željko Žižak, Anica Joksić, Dolores Opačić, and Vladimir Biočanin. "Antiproliferative Effect of Spilanthes Acmella Extracts on Human Cervix Adenocarcinoma and Human Myelogenous Leukemia Cells." Acta Veterinaria 74, no. 3 (2024): 538–45. https://doi.org/10.2478/acve-2024-0037.

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Abstract Reactive oxygen and nitrogen species (RONS) play a crucial role in the pathogenesis of various chronic diseases, including cancer, by reacting with fundamental biomolecules. While conventional anticancer treatments such as ionizing radiation and chemotherapy have significant adverse effects, some medicinal plants exhibit free radical scavenging and anticancer activities. Spilanthes acmella L., commonly known as the toothache plant, is reported to have various bioactive compounds with antioxidant and anticancer properties. The aim of this study was to investigate and evaluate antiproli

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Bozorov, Kh A., N. Z. Mamadalieva, B. Zh Elmuradov, et al. "Synthesis of Substituted Thieno[2,3-d]pyrimidin-4-ones and Their Testing for Evaluation of Cytotoxic Activity on Mammalian Cell Models." Journal of Chemistry 2013 (2013): 1–6. http://dx.doi.org/10.1155/2013/976715.

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From 2-amino-3-ethoxycarbonyl-4,5-dimethyl-, -polymethylenethiophenes (1-4) were synthesized 2,3-disubstituted thieno[2,3-d]dihydropyrrolo-, tetrahydropyrido-, and tetrahydroazepino[1,2-a]pyrimidin-4-ones (5-16) for pharmacological investigations. The 12 compounds (5-16) were individually evaluated for their antiproliferative activities on mammalian cancer cell models. All tested compounds showed weak affection on human cervix adenocarcinoma cells (HeLa) whereas some of the tested compounds exhibited more consistent inhibition of cell growth on murine myeloma cells (P3X). In both cases some co

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Ouerfelli, Manel, Isidoro Metón, Idoia Codina-Torrella, and María Pilar Almajano. "Antibacterial and Antiproliferative Activities of Azadirachta indica Leaf Extract and Its Effect on Oil-in-Water Food Emulsion Stability." Molecules 27, no. 22 (2022): 7772. http://dx.doi.org/10.3390/molecules27227772.

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The present study aims to identify and quantify the phenolic compounds of Azadirachta indica leaf extract using HPLC-MS and to evaluate the antioxidant, antibacterial (against different Gram-positive and negative bacteria) and in vitro anti-proliferative activities of this extract (against breast, human liver and cervix adenocarcinoma-derived cells). The application of this extract as a natural antioxidant for food preservation was also tested on oil-in-water food emulsions for the first time in the present work in order to determine the use of Azadirachta indica leaves as a natural additive t

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Chaturvedi, Anil K., Ruth A. Kleinerman, Allan Hildesheim, et al. "Second Cancers After Squamous Cell Carcinoma and Adenocarcinoma of the Cervix." Journal of Clinical Oncology 27, no. 6 (2009): 967–73. http://dx.doi.org/10.1200/jco.2008.18.4549.

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Purpose Although cervical squamous cell carcinoma (SCC) and adenocarcinoma (AC) are both caused by human papillomavirus (HPV) infection, they differ in cofactors such as cigarette smoking. We assessed whether these cofactor differences translate into differences in second cancer risk. Patients and Methods We assessed second cancer risk among 85,109 cervical SCC and 10,280 AC survivors reported to population-based cancer registries in Denmark, Finland, Norway, Sweden, and the United States. Risks compared to the general population were assessed using standardized incidence ratios (SIR). Results

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Porika, Mahendar, Radhika Tippani, Anwar Mohammad, Sekhar R. Bollam, Sree D. Panuganti, and Sadanandam Abbagani. "Evaluation of Serum Human Telomerase Reverse Transcriptase as a Novel Marker for Cervical Cancer." International Journal of Biological Markers 26, no. 1 (2011): 22–26. http://dx.doi.org/10.5301/jbm.2011.6352.

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Human telomerase reverse transcriptase (hTERT) is the catalytic subunit of human telomerase and its rate-limiting component. The purpose of the present study was to investigate the diagnostic value of hTERT in serum of cervical cancer patients. Preoperative values of hTERT, squamous cell carcinoma antigen (SCC-ag) and cancer antigen 125 (CA 125) were measured by enzyme-linked immunosorbent assay (ELISA) in 192 patients with squamous cell carcinoma or adenocarcinoma of the uterine cervix and 38 healthy controls. Elevated pretreatment levels of hTERT were identified in 80.2% of squamous cell car

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Danciu, Corina, Codruta Soica, Cristina Dehelean, Istvan Zupko, Erzsebet Csanyi, and Iulia Pinzaru. "PreliminaryIn VitroEvaluation of Genistein Chemopreventive Capacity as a Result of Esterification and Cyclodextrin Encapsulation." Analytical Cellular Pathology 2015 (2015): 1–8. http://dx.doi.org/10.1155/2015/262930.

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The present study focuses on the synthesis and analysis of a genistein ester derivative with myristic acid followed by beta cyclodextrin encapsulation; physicochemical analysis using consecrated techniques such as FTIR, MS, DSC, and SEM revealed both a successful esterification and inclusion inside the cyclodextrin cavity. Cytotoxic effects were measuredin vitroon three human cell lines: HeLa (cervix adenocarcinoma), A2780 (ovary carcinoma), and A431 (skin epidermoid carcinoma). Thein vitrobiological analysis exhibited rather poor antiproliferative results on all three tested cancer cell lines

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Kundu, Gopa, Sabera Khatun, Shirin Akter, et al. "Distribution of Type Specific Human Papilloma Virus DNA Among Women of Cervical Cancer in a Tertiary Level Hospital." Bangladesh Medical Research Council Bulletin 48, no. 1 (2022): 48–55. http://dx.doi.org/10.3329/bmrcb.v48i1.60660.

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Background: Infection with high-risk human papilloma virus (HPV) has been recognised as a causal factor for development of cervical pre-cancerous and cancerous lesions. So far more than 150 types of HPV are identified. Their distribution varies from country to country, also from region to region. Background knowledge about the distribution of HPV genotypes in invasive cervical cancer is crucial to guide the introduction of prophylactic vaccines. Objective: The study was aimed to assess the distribution of type specific human papilloma Virus DNA among cervical cancer patients. Methods: The stud

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Pantelic, Nebojsa, Bojana Zmejkovski, Tatjana Stanojkovic, et al. "Synthesis and high in vitro cytotoxicity of some (S,S)-ethylenediamine-N,N’-di-2-propanoate dihydrochloride esters." Journal of the Serbian Chemical Society 79, no. 6 (2014): 649–58. http://dx.doi.org/10.2298/jsc130512022p.

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Novel (S,S)-R2eddip ester, O,O?-diisoamyl-(S,S)-ethylenediamine-N,N?-di-2-propanoate dihydrochloride, 1, was synthesized and characterized by IR, 1H and 13C NMR spectroscopy, mass spectroscopy and elemental analysis.In vitro antitumor action of 1, and two more R2eddip esters, O,O?-dialkyl-(S,S)-ethylenediamine-N,N?-di-2-propanoate dihydrochlorides, obtained before, (alkyl = n-Bu, n-Pe; 2 and 3, respectively), was determined against cervix adenocarcinoma (HeLa), human melanoma (Fem-x), human chronic myelogenous leukemia (K562) cells, and a non-cancerous cell line human embryonic lung fibroblast

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Facchetti, Giorgio, Michael S. Christodoulou, Lina Barragán Mendoza, Federico Cusinato, Lisa Dalla Via, and Isabella Rimoldi. "Biological Properties of New Chiral 2-Methyl-5,6,7,8-tetrahydroquinolin-8-amine-based Compounds." Molecules 25, no. 23 (2020): 5561. http://dx.doi.org/10.3390/molecules25235561.

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The synthesis of a small library of 8-substituted 2-methyl-5,6,7,8-tetrahydroquinoline derivatives is presented. All the compounds were tested for their antiproliferative activity in non-cancer human dermal microvascular endothelial cells (HMEC-1) and cancer cells: human T-lymphocyte cells (CEM), human cervix carcinoma cells (HeLa), human dermal microvascular endothelial cells (HMEC-1), colorectal adenocarcinoma (HT-29), ovarian carcinoma (A2780), and biphasic mesothelioma (MSTO-211H). Compounds 3a, 5a, and 2b, showing significant IC50 values against the whole panel of the selected cells, were

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Andersson, Sonia, Barbro Larson, Anders Hjerpe, et al. "Adenocarcinoma of the uterine cervix: the presence of human papillomavirus and the method of detection." Acta Obstetricia et Gynecologica Scandinavica 82, no. 10 (2003): 960–65. http://dx.doi.org/10.1034/j.1600-0412.2003.00263.x.

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Teshima, H., S. Beaudenon, S. Koi, et al. "Human papillomavirus type 18 DNA sequences in adenocarcinoma and adenosquamous carcinoma of the uterine cervix." Archives of Gynecology and Obstetrics 259, no. 4 (1997): 169–77. http://dx.doi.org/10.1007/s004040050155.

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Teshima, H., S. Beaudenon, S. Koi, et al. "Human papillomavirus type 18 DNA sequences in adenocarcinoma and adenosquamous carcinoma of the uterine cervix." Archives of Gynecology and Obstetrics 259, no. 4 (1997): 169–77. http://dx.doi.org/10.1007/bf02505329.

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Uchiyama, Michiko, Tsuyoshi Iwasaka, Norihito Matsuo, Toru Hachisuga, Mitsuru Mori, and Hajime Sugimori. "Correlation between Human Papillomavirus Positivity and p53 Gene Overexpression in Adenocarcinoma of the Uterine Cervix." Gynecologic Oncology 65, no. 1 (1997): 23–29. http://dx.doi.org/10.1006/gyno.1997.4613.

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