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Dissertations / Theses on the topic 'Human dendritic cell'

Author: Grafiati

Published: 11 March 2023

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1

Morel, Anne-Sophie. "Manipulation of human dendritic cell function." Thesis, Imperial College London, 1999. http://hdl.handle.net/10044/1/11840.

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2

Jones, Angela. "Human dendritic cell interactions with respiratory syncytial virus." Thesis, University of Sheffield, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.289663.

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3

Heijstek, Helena Cornelia. "Modulation of human dendritic cell function by therapeutic agents." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2002. http://dare.uva.nl/document/64240.

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4

Schäkel, Knut, Claudia Poppe, Elfriede Mayer, Christine Federle, Gert Riethmüller, and Ernst Peter Rieber. "M-DC8+ Leukocytes – A Novel Human Dendritic Cell Population." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-135252.

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Dendritic cells (DC) constitute a heterogeneous leukocyte population having in common a unique capacity to induce primary T cell responses and are therefore most attractive candidates for immunomodulatory strategies. Two populations of blood DC (CD11c+ CD123dim and CD11c– CD123high) have been defined so far. However, their direct isolation for experimental purposes is hampered by their low frequency and by the lack of selective markers allowing large scale purification from blood. Here we describe the monoclonal antibody (mAb) M-DC8, which was generated by immunizing mice with highly enriched

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Schäkel, Knut, Claudia Poppe, Elfriede Mayer, Christine Federle, Gert Riethmüller, and Ernst Peter Rieber. "M-DC8+ Leukocytes – A Novel Human Dendritic Cell Population." Karger, 1999. https://tud.qucosa.de/id/qucosa%3A27632.

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Dendritic cells (DC) constitute a heterogeneous leukocyte population having in common a unique capacity to induce primary T cell responses and are therefore most attractive candidates for immunomodulatory strategies. Two populations of blood DC (CD11c+ CD123dim and CD11c– CD123high) have been defined so far. However, their direct isolation for experimental purposes is hampered by their low frequency and by the lack of selective markers allowing large scale purification from blood. Here we describe the monoclonal antibody (mAb) M-DC8, which was generated by immunizing mice with highly enriched

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6

Sampangi, Sandeep. "Autologous human kidney proximal tubule epithelial cells (PTEC) modulate dendritic cell (DC), T cell and B cell responses." Thesis, Queensland University of Technology, 2015. https://eprints.qut.edu.au/82033/1/Sandeep_Sampangi_Thesis.pdf.

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This is a comprehensive study of human kidney proximal tubular epithelial cells (PTEC) which are known to respond to and mediate the pathological process of a range of kidney diseases. It identifies various molecules expressed by PTEC and how these molecules participate in down-regulating the inflammatory process, thereby highlighting the clinical potential of these molecules to treat various kidney diseases. In the disease state, PTEC gain the ability to regulate the immune cell responses present within the interstitium. This down-regulation is a complex interaction of contact dependent/indep

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7

Hu, Yaling. "Fucoidin enhances dendritic cell-mediated T-cell cytotoxicity against NY-ESO-1 expressing human cancer cells /." View abstract or full-text, 2008. http://library.ust.hk/cgi/db/thesis.pl?BIOL%202008%20HU.

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8

Varani, Stefania. "Human cytomegalovirus and dendritic cell interaction : role in immunosuppression and autoimmunity /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-505-4/.

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9

NIZZOLI, GIULIA. "Human dendritic cell subsets: cytokine production and their role in T-cell priming." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2014. http://hdl.handle.net/10281/50066.

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Dendritic cells (DC) have the unique capacities to induce primary T cell responses. In mice, CD8α+DC are specialized to cross-prime CD8+ T-cells and produce IL-12 that promotes cytotoxicity. Human BDCA-3+DC share several relevant characteristics with CD8α+DC, but the capacities of human DC subsets to induce CD8+ T cell responses are incompletely understood. Here we compared CD1c+mDC1, BDCA-3+mDC2 and plasmacytoid DC (pDC) in peripheral blood and lymphoid tissues for phenotype, cytokine production and their capacities to prime cytotoxic T cells. mDC1 were surprisingly the only human DC that

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10

Thacker, Robert I. "Modulation of Human Dendritic Cell Activity by Adsorbed Fibrin(ogen)." University of Cincinnati / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1218553202.

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11

Che, Karlhans Fru. "Immunomodulatory Effects of Human ImmunodeficiencyVirus (HIV-1) on Dendritic Cell and T cell Responses : Studies of HIV-1 effects on Dendritic cell functionality reflected in primed T cells." Doctoral thesis, Linköpings universitet, Molekylär virologi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-71279.

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The human immunodeficiency virus (HIV)-1 is the causative agent of acquired immune deficiency syndrome (AIDS) worldwide. Till date there are no vaccines or cure for this infection as the virus has adapted myriad ways to remain persistent in the host where it causes severe damage to the immune system. Both humoral and cellular immune responses are mounted against HIV-1 during the initial phase of infection but fail to control viral replication as these responses are severely depleted during disease progression. Of great importance in HIV-1 research today is the in depth understanding of the typ

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12

Foged, Camilla. "Human dendritic cells : cell culture, models for studies of particulate antigen, formulation in vitro /." Cph., Stockholm : Department of Pharmaceutics, The Danish University of Pharmaceutical Sciences, Division of Hematology, Center for Molecular Medicine, Karolinska Hospital and Institute, 2003. http://www.dfh.dk/phd/defences/Camillafoged.htm.

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13

Johansson, Ulrika. "Modulation of human dendritic cell function by microbial or autologous stimuli." Thesis, Imperial College London, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270951.

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14

Shirley, Shawna A. "The Role Of Curcumin In Human Dendritic Cell Maturation And Function." [Tampa, Fla] : University of South Florida, 2008. http://purl.fcla.edu/usf/dc/et/SFE0002666.

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15

Yamamoto, Kazuyo. "Anti-inflammatory modulation of human myeloid-derived dendritic cell subsets by lenalidomide." Kyoto University, 2020. http://hdl.handle.net/2433/259726.

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16

Wang, Changna. "Follicular Dendritic Cells, Resting CD4+ T Cells and Human Immunodeficiency Virus Expression." BYU ScholarsArchive, 2011. https://scholarsarchive.byu.edu/etd/2906.

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Many events associated with Human Immunodeficiency Virus (HIV) infection/replication occur in and around the germinal centers (GCs) of secondary lymphoid tissues where follicular dendritic cells (FDCs) reside, suggesting that this microenvironment may contribute unique signaling that is important to viral progression. My research focused on characterizing signaling, both positive and negative, contributed by FDCs that affects HIV infection and replication. Specifically, I determined if FDC signals could induce the expression of latent HIV in T cells and if so, to characterize the signaling pat

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17

Kouremenou, Chrisoula. "The effects of tick immunomodulators on human dendritic cell differentiation and function." Thesis, University of Oxford, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.442819.

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18

Metelo, J. "Contribution of integrins and actin regulators to human dendritic cell podosome biology." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1381835/.

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Dendritic cells (DC) are key cells of the innate immune system required to prime adaptive immunity. Migration is central to their function to enable immune surveillance of the whole body and for prompt activation of the adaptive immune system. Immature DC assemble specialised actin structures called podosomes which are thought to be critical for efficient adhesion-mediated migration. Podosomes are, therefore, considered to be essential for DC function. Despite the great increase in literature regarding podosomes and related structures over recent years, still much is unknown about critical com

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19

Martinez, Cingolani Carolina. "Differential Effects of the Cytokine Thymic Stromal Lymphopoietin on Human Dendritic Cell Subsets." Thesis, Paris 11, 2013. http://www.theses.fr/2013PA11T083/document.

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Une fois activées, les cellules dendritiques (DCs) migrent dans les organes lymphoïdes ou elles exercent leur rôle de cellules présentatrices d’antigène professionnelles. Elles sont capables d’activer et d’induire la différenciation des lymphocytes T naïfs en différentes sous-populations de lymphocytes T auxiliaires. L’ajustement de la réponse lymphocytaire T au type d’inflammation est assuré par les DCs à deux niveaux. Premièrement, grâce à leur plasticité, les DCs adaptent leur comportement en fonction de la combinaison de signaux issus du microenvironnement inflammatoire. Deuxièmement, il e

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20

Salvatore, Giulia. "Remodeling of lipid metabolism by interleukin-17A in human dendritic cells." Thesis, Lyon 1, 2012. http://www.theses.fr/2012LYO10268.

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Nous avons découvert que les DC pathologiques (LCH DC) qui s’accumulent dans les granulomes de patients atteints d’histiocytose langerhansienne (LCH) produisent l’IL-17A (Coury et al, Nat Med 2008). In vitro, les LCH DC fusionnent en cellules géantes (MGC) sous l’influence de leur production autocrine d’IL-17A. In vivo, les granulomes de LCH DC et MGC détruisent les tissus. Pendant la thèse, nous avons étudié les transcriptomes des monocytes, DC, traitées ou non par l’IL-17A et des LCH DC. L’IL-17A induit BCL2A1, un membre de la famille Bcl-2 qui prolonge la survie des DC. Elle induit aussi le

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21

Alculumbre, Solana. "Division of Labor Between Distinct Human Plasmacytoid Dendritic Cell Subsets Following Viral Activation." Thesis, Université Paris-Saclay (ComUE), 2015. http://www.theses.fr/2015SACLS014.

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L’existence d’un partage des tâches a été démontrée au sein de nombreux systèmes biologiques et ce notamment en immunologie où il a été décrit dans le contexte de différentes sous-populations d’un même type cellulaire. Les cellules dendritiques plasmacytoïdes (pDC) jouent un rôle clé lors des infections virales. Les pDCs ont la capacité de sécréter de grandes quantités d’interférons de type I et de se différencier en cellules dendritiques matures capables d’activer une réponse immunitaire adaptative. Il a été proposé que ces fonctions innées et adaptatives soient séquentiellement induites aprè

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22

Fenton, Thomas. "Integrin αvβ8 on human dendritic cells : a role in intestinal immune homeostasis". Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/integrin-alphav8-on-human-dendritic-cells-a-role-in-intestinal-immune-homeostasis(3820bc76-2c42-4db6-a344-b66e5b77769d).html.

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Intestinal inflammatory disorders such as Crohn’s disease contribute significantly to human mortality and morbidity. Although the cells and molecules involved in suppression of intestinal inflammation have been extensively documented in mouse models, a full understanding of how these work together in the healthy and diseased gut remains elusive. It is known, however, that tight regulation over TH17 cells and regulatory T cells (Treg) is required to maintain immune homeostasis in the intestine. Activation of the cytokine transforming growth factor-β (TGFβ), which is secreted by immune cells as

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23

ORSENIGO, FEDERICA. "Characterisation of the myeloid CSF1R+ dendritic cell subsets and monocytes in health and disease." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2023. https://hdl.handle.net/10281/404675.

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Le cellule dendritiche (DC) e i monociti sono cellule immunitarie innate coinvolte nel riconoscimento di patogeni e molecole associate a danno, nello scatenare l’immunità adattativa e nel mantenimento dell’omeostasi. Queste cellule sono collettivamente chiamate cellule del sistema fagocitico mononucleare (MPS), e la loro origine ed il loro sviluppo nell’uomo richiedono ancora studio. I recettori delle citochine determinanti l’origine (LDCR) sono fattori di crescita con importante ruolo nel differenziamento e nella sopravvivenza delle cellule ematopoietiche. Questi recettori sono presenti anche

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24

Gustafsson, Linnéa. "Internalisation of antigen-adjuvant conjugate in human dendritic cells : An assay development for using live cell imaging." Thesis, Uppsala universitet, Institutionen för farmaceutisk biovetenskap, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-434224.

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Introduction: Cancer vaccines are a therapeutic approach to initiate an antigen specific cytotoxic immune responses against tumors. Cancer vaccines are composed by an antigen (tumor peptide) and adjuvant. A peptide in combination with adjuvants effectively activate dendritic cells (DCs), the most efficient antigen presenting cells in our immune system. DCs prime and activate CD8+ cytotoxic T cells which generates an antigen specific response.Aim: Developing an assay to study the internalisation rout of an antigen-adjuvant conjugate in human dendritic cells by using live cell imaging. Method: I

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25

Rossi, Axel. "Intracellular fate of AAV particles in human Dendritic Cell and impact on Gene Transfer." Thesis, Lyon, 2016. http://www.theses.fr/2016LYSEN028.

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Les vecteurs viraux dérivés du virus adéno-associé (AAV) apparaissent depuis deux décennies, comme des outils efficaces pour le transfert de gène in vivo. Cependant, malgré une faible immunogénicité et une absence de toxicité in vivo, leur optimisation requiert encore un effort important vers une meilleure compréhension de leur biologie et, en particulier, de leur interaction avec le système immunitaire. Au cours de ce travail de thèse, nous avons utilisé une méthode de sélection dirigée in vitro dans le but d’obtenir un variant de capside capable de transduire efficacement un type cellulaire

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26

Wahid, S. Fadilah Binti Abdul. "Development of functional human dendritic cell subsets in vitro and in vivo in hu/NOD/SCID chimeric mice : important implications in dentritic cell-based immunotherapy /." [St. Lucia, Qld.], 2005. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe19089.pdf.

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27

Poulsen, Christopher. "Differential cytotoxicity of long-chain bases for human oral keratinocytes, fibroblasts, dendritic and oral squamous cell carcinoma cell lines." Thesis, University of Iowa, 2014. https://ir.uiowa.edu/etd/4723.

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Long-chain bases (sphingosine, dihydrosphingosine, and phytosphingosine) are present in the oral cavity and have potent antimicrobial activity against oral pathogens. However, little is known about their cytotoxicity for oral cells, an important step in considering their potential as future antimicrobial agents for oral infections. In this study, primary oral keratinocytes, primary oral fibroblasts, dendritic cells, and oral squamous cell carcinoma cells were exposed to 10.0-640.0 µM long-chain bases and glycerol monolaurate (GML) in cell culture medium containing resazurin (e.g., Alamar Blue,

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28

Botting, Rachel Anne. "Investigating the phenotype and frequency of mononuclear phagocytes in human skin and anogenital tissue: potential targets to prevent HIV transmission." Thesis, The University of Sydney, 2016. http://hdl.handle.net/2123/15627.

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Mononuclear phagocytes are located throughout the body, and include DCs, macrophages and monocytes. One of their key functions is the detection of pathogens via an array of surface molecules. Determining the repertoire of surface molecules on each subset could reveal targets for DC-based vaccines and potential pathogen interactions. Furthermore, identifying which subsets are present in each of the anogenital tissues may increase understanding of the pathogenesis of various sexually transmitted infections, including HIV. To investigate the phenotype and frequency of mononuclear phagocytes in hu

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29

Duraisingham, Sai Suda. "The Role of Toll-like Receptors in Immune Responses Mediated by Human Dendritic Cell Subsets." Thesis, Imperial College London, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.516478.

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30

Gonzalez, Ana Maria. "Studies of human rotavirus candidate non-replicating vaccines and innate immunity in a gnotobiotic pig model of human rotavirus disease." The Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=osu1172622915.

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31

Thomas, Saskia. "Aberrant response of human myeloid dendritic cells to microbial stimuli in patients with inflammatory bowel disease." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2011. http://dx.doi.org/10.18452/16340.

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In zahlreichen Studien konnte an Mausmodellen gezeigt werden, dass dendritische Zellen eine wichtige Rolle im Rahmen der mukosalen Immunabwehr spielen. Eine unkontrollierte Aktivierung immunologischer Effektorzellen durch antigenpräsentierende Zellen ist die Folge, welche die Antigene der luminalen Flora folglich falsch erkennen und damit zu einer Schädigung des Gewebes führen. In der Arbeit wurden humane CD1c+CD11c+CD14-CD19- myeloide dendritische Zellen (mDCs) aus dem peripheren Blut und der intestinalen Mukosa von CED Patienten sowie von gesunden Probanden phänotypisch und funktionell näher

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32

Sontag, Stephanie Verfasser], Martin [Akademischer Betreuer] Zenke, and Ralph [Akademischer Betreuer] [Panstruga. "Modeling IRF8 Deficient Human Hematopoiesis and Dendritic Cell Development with Engineered iPS Cells / Stephanie Sontag ; Martin Zenke, Ralph Panstruga." Aachen : Universitätsbibliothek der RWTH Aachen, 2017. http://d-nb.info/1162450509/34.

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Sontag, Stephanie [Verfasser], Martin Akademischer Betreuer] Zenke, and Ralph [Akademischer Betreuer] [Panstruga. "Modeling IRF8 Deficient Human Hematopoiesis and Dendritic Cell Development with Engineered iPS Cells / Stephanie Sontag ; Martin Zenke, Ralph Panstruga." Aachen : Universitätsbibliothek der RWTH Aachen, 2017. http://d-nb.info/1162450509/34.

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34

Tabata, Sumie. "Distribution and kinetics of SR-PSOX/CXCL16 and CXCR6 expression on human dendritic cell subsets and CD4[+] T cells." Kyoto University, 2006. http://hdl.handle.net/2433/143841.

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35

Trichot, Coline. "Regulation of Human T Helper Cell Diversity : From In Vitro Dendritic Cell-Based Mechanisms to Candidate Biomarkers in Atopic Dermatitis." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS423.

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Le système immunitaire humain est majoritairement commandé par les cellules dendritiques et les lymphocytes T auxiliaires. Lorsque les cellules dendritiques détectent un pathogène, elles vont instruire les lymphocytes T auxiliaires afin qu’ils adoptent le phénotype approprié à la menace rencontrée. Les lymphocytes T auxiliaires peuvent être divisés en plusieurs sous-populations, caractérisées par la production de cytokines spécifiques. Chaque sous-population de lymphocyte T auxiliaire possède des fonctions propres et est impliquée dans l’élimination de pathogènes distincts. Si les réponses des

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36

Leishman, Alison Jane. "Harnessing the immunomodulatory capacity of dendritic cells differentiated from human induced pluripotent stem cells and the therapeutic potential of dendritic cell-derived exosomes for the treatment of lysosomal storage diseases." Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:97f6791f-ff69-4645-9a3d-2ff23ce69529.

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Lysosomal storage diseases (LSDs) are a collection of disorders that feature the pathological accumulation of substrate frequently due to an enzymatic defect within the lysosomes. The most effective treatment regime for LSDs is enzyme replacement therapy. However, this treatment has faced two main challenges which have limited its treatment efficacy and clinical impact. One challenge constitutes the potential immunogenicity of the replaced enzyme, which can lead to the induction of an antibody response that prevents its effective targeting. Therefore, this thesis investigated the potential to

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Leishman, Alison Jane. "Harnessing the immonomodulatory capacity of dendritic cells differentiated from human induced pluripotent stem cells and the therapeutic potential of dendritic cell-derived exosomes for the treatment of lysosomal storage diseases." Thesis, University of Oxford, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.711748.

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38

Wildemann, Martha. "Pollutants and immune regulation in the human airway : modulation of dendritic cell function by environmental particulate matter." Thesis, Queen Mary, University of London, 2018. http://qmro.qmul.ac.uk/xmlui/handle/123456789/43184.

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Ambient air pollution, including airborne particulate matter (PM) derived from combustion of fossil fuels (FF) or biomass (BM), has detrimental inflammatory effects on human health. Myeloid antigen presenting cells, including dendritic cells (DCs) regulate immune responses in the airway and sample inhaled PM. This study tests the hypothesis that PM interacts with multiple environmental sensing pathways in DCs with outcomes that depend on particle size and composition as determined by combustion source. The effects of different sized PM (< 10μm, PM10; < 2.5μm, PM2.5), derived from the combustio

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Henriquez, Rodney Fabian. "Varicella Zoster Virus infection of human matured monocyte derived dendritic cells & its impact on their effector functions." Thesis, The University of Sydney, 2015. http://hdl.handle.net/2123/13624.

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Varicella Zoster Virus (VZV) is a species specific alpha human herpes virus that causes both Varicella (chickenpox) and Herpes Zoster (shingles) in human hosts. It has been hypothesized that host dendritic cells (DC) play a pivotal role in the pathogenesis of VZV during the early stages of infection. DC have previously been shown to be permissive to VZV infection and capable of transmitting the virus to human T lymphocytes. VZV has also been shown to employ a variety of mechanisms to evade detection and clearance by the host immune system. The primary aim of this study was to identify the und

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Schanen, Brian. "Novel Immunogens of Cellular Immunity Revealed using in vitro Human Cell-Based Approach." Doctoral diss., University of Central Florida, 2012. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/5483.

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Nanotechnology has undergone rapid expansion largely as a result of its enormous potential for applications as biomaterials, drug delivery vehicles, cancer therapeutics, and immunopotentiators. Despite this wave of interest and broad appeal for nanoparticles, evidence of their effect to the human immune system remains scarce. Concerns rise as studies on nanoparticle toxicology continue to emerge indicating that nanomaterials can be acutely toxic and can have long term inflammatory effects as seen in animal models. Based on these findings and the rise in the development of nanoparticle technolo

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MacDonald, Kelly Lynn. "Inflammation in chronic granulomatous disease and modulation of human dendritic cell functions by Burkholderia cenocepacia and Burkholderia multivorans." Thesis, University of British Columbia, 2009. http://hdl.handle.net/2429/11136.

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Inflammation and infection are integral to the human diseases cystic fibrosis (CF) and chronic granulomatous disease (CGD). Inflammation was examined in peripheral blood mononuclear cells (PBMCs) from CGD patients. Reactive oxygen species (ROS) generated by the phagocytic NADPH oxidase have been implicated in the activation of the NF-κB, a transcription factor required for proinflammatory cytokine production in response to inflammatory stimuli. Patients with CGD, an immunodeficiency characterized by the inability to produce ROS, frequently develop inflammatory complications indicative of ex

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42

Miyamoto, Kazue. "Optimal stimulation for CD70 induction on human monocyte-derived dendritic cells and the importance of CD70 in naive CD4+ T cell differentiation." Kyoto University, 2010. http://hdl.handle.net/2433/120928.

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43

Royle, Caroline. "Plasmacytoid dendritic cell activation and differentiation by the Human Immunodeficiency Virus type 1 and 2 : implications for HIV immunopathogenesis." Thesis, Imperial College London, 2014. http://hdl.handle.net/10044/1/24938.

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Infection with HIV-1 results in the progressive dysfunction of the immune system eventually leading to AIDS, characterised by low CD4+ T lymphocyte counts and increased susceptibility to opportunistic infections. In contrast to HIV-1, individuals infected with HIV-2 often remain asymptomatic, with lower viral loads and higher CD4+ T cell counts throughout the course of disease. Furthermore, HIV-2+ individuals display enhanced HIV-specific T cell responses. In addition, HIV-1 disease progression is slower in patients with pre-existing HIV-2 infection. Plasmacytoid dendritic cells (pDCs) are key

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44

Bachmann, Michael, Holger Bartsch, Biji T. Kurien, et al. "A Novel Modular Antigen Delivery System for Immuno Targeting of Human 6-sulfo LacNAc-Positive Blood Dendritic Cells (SlanDCs)." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-186316.

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Background Previously, we identified a major myeloid-derived proinflammatory subpopulation of human blood dendritic cells which we termed slanDCs (e.g. Schäkel et al. (2006) Immunity 24, 767–777). The slan epitope is an O-linked sugar modification (6-sulfo LacNAc, slan) of P-selectin glycoprotein ligand-1 (PSGL-1). As slanDCs can induce neoantigen-specific CD4+ T cells and tumor-reactive CD8+ cytotoxic T cells, they appear as promising targets for an in vivo delivery of antigens for vaccination. However, tools for delivery of antigens to slanDCs were not available until now. Moreover, it is un

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Karpf, Léa. "Systematic Study of OX40 Ligand Context-Dependent Function on Human T Helper Cell Polarization A Quantitative Multivariate Model of Human Dendritic Cell-T Helper Cell Communication TH Cell Diversity and Response to Dupilumab in Patients With Atopic Dermatitis Inborn Errors of Type I IFN Immunity in Patients With Life-Threatening COVID-19 Quantitative Modeling of OX40 Ligand Context-Dependent Function on Human T Helper Cell SARS-CoV-2 Induces Activation and Diversification of Human Plasmacytoid Pre-Dendritic Cells." Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASL044.

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L'immunité adaptative est principalement orchestrée par des lymphocytes T CD4 auxiliaires. Ils ont la capacité de se polariser en plusieurs sous-populations, chacune associée à un phénotype approprié au pathogène rencontré. L'activation des lymphocytes T auxiliaires peut être régulée par des checkpoints immunitaires co-stimulateurs, tel que OX40 Ligand, ou co-inhibiteurs. Ces molécules ont été étudiées individuellement, dans des conditions spécifiques. Cependant, la contexte-dépendance pourrait expliquer une grande partie de la variabilité fonctionnelle des biomolécules. Il n'y a actuellement

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46

Bachmann, Michael, Holger Bartsch, Biji T. Kurien, et al. "A Novel Modular Antigen Delivery System for Immuno Targeting of Human 6-sulfo LacNAc-Positive Blood Dendritic Cells (SlanDCs)." PLOS, 2011. https://tud.qucosa.de/id/qucosa%3A29020.

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Background Previously, we identified a major myeloid-derived proinflammatory subpopulation of human blood dendritic cells which we termed slanDCs (e.g. Schäkel et al. (2006) Immunity 24, 767–777). The slan epitope is an O-linked sugar modification (6-sulfo LacNAc, slan) of P-selectin glycoprotein ligand-1 (PSGL-1). As slanDCs can induce neoantigen-specific CD4+ T cells and tumor-reactive CD8+ cytotoxic T cells, they appear as promising targets for an in vivo delivery of antigens for vaccination. However, tools for delivery of antigens to slanDCs were not available until now. Moreover, it is un

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Reuter, Morgan Ann. "Mycobacterium tuberculosis-induced changes in HIV-1 trafficking in human antigen presenting cells." Case Western Reserve University School of Graduate Studies / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=case1278699683.

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SARGENTINI, VALERIA. "Activated T lymphocytes instruct monocytes to differentiate into inflammatory dendritic cells in a feedback control of human Th1/Th2 responses." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2009. http://hdl.handle.net/2108/988.

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Le cellule dendritiche (DCs) rappresentano una popolazione di cellule eterogenea con diversa origine, fenotipo e funzione che svolge un ruolo chiave nell' induzione, coordinazione e mantenimento delle risposte immunitarie adattative. La maggior parte delle conoscenze riguardanti le DCs sono state acquisite grazie ad esperimenti eseguiti con DCs fatte differenziare in vitro da monociti trattati con diverse combinazioni di citochine; in particolare è ormai noto che i monociti umani differenziano a DCs se coltivati con il fattore di stimolazione di colonie granulocita rie/macrofagiche(GM-CSF) e

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Noël, Floriane. "Systems Level Analysis of Immune Cell Subsets and Intercellular Communication Networks in Human Breast Cancer." Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLS418/document.

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La communication intercellulaire est à la base de l'organisation d'ordre supérieur observée dans les tissus, les organes et l'organisme. Comprendre la communication intercellulaire et ses mécanismes sous-jacents qui sont impliqués dans le cancer est essentiel. Le microenvironnement des tumeurs du sein est composé d'une grande diversité cellulaire, telle que les cellules endothéliales, stromales ou immunitaires, qui peuvent influencer la progression tumorale ainsi que la réponse au traitement. Parmi les différentes populations de cellules immunitaires, les sous-populations de cellules dendritiq

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Abozaid, Suhair Mohamed. "Studies on the interaction of surfactant protein SP-D with Inflenza A virus, Aspergillus fumigatus and dendritic cells." Thesis, Brunel University, 2016. http://bura.brunel.ac.uk/handle/2438/13595.

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Surfactant proteins, SP-A and SP-D, are collagen-containing calcium-dependent (C-type) lectins, called, collectins. Their primary structure has four regions: a cysteine-linked N- terminal region involved in multimerization, a collagen region composed of Gly-X-Y repeats, coiled-coil neck region, and the C-terminal carbohydrate recognition domains (CRD) or C-type lectin domain. SP-A looks like a bouquet, while SP-D is a cruciform- like structure, with four arms of equal length. SP-A and SP-D have been shown to act as innate immune molecules at pulmonary as well as extra-pulmonary sites by bindin

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