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Dissertations / Theses on the topic 'Human engineering'

Author: Grafiati
Published: 4 June 2021
Last updated: 29 July 2024

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1

Thoms, Joanne. "Human centric systems engineering." Thesis, University of Bath, 2009. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.501636.

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This thesis is a study into an engineering technology that enables us to investigate the cognitive aspects of systems. Where previous techniques have focused on individual human roles undertaking defined tasks, this work develops engineering technologies to understand the cognitive contribution of the human team participating in the system and how the deployment of machine decision making technologies can influence and change the possible human contribution in that system. This work first develops a framework for understanding an individual’s cognitive focus and then an engineering process tha
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2

Marsano, Anna. "Engineering of human meniscus substitute /." [S.l.] : [s.n.], 2006. http://library.epfl.ch/theses/?nr=3439.

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3

Higgins, Jonathan M. G. "Protein engineering of human properdin." Thesis, University of Oxford, 1994. http://ora.ox.ac.uk/objects/uuid:80236e86-789e-4028-aad0-e72223f7645a.

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Properdin is a serum glycoprotein that upregulates the alternative pathway of complement by stabilizing the C3bBb complex. It also binds sulphated glycoconjugates, such as sulphatide, in vitro. Properdin is composed of cyclic dimers, trimers and tetramers of a 53 kDa monomeric subunit. The monomer contains an N-terminal region of no known homology and six thrombospondin type 1 repeats (TSRs) of approximately sixty amino acids. The sixth TSR of properdin contains an insertion of approximately 30 amino acids which corresponds to the position of an intron in the human properdin gene. In order to
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4

Philippart, Monica. "IMPROVING BUSINESS PERFORMANCE THROUGH THE INTEGRATION OF HUMAN FACTORS ENGINEERING INTO ORGANIZATIONS USING A SYSTEMS ENGINEERI." Doctoral diss., University of Central Florida, 2008. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/3257.

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Most organizations today understand the valuable contribution employees as people (rather than simply bodies) provide to their overall performance. Although efforts are made to make the most of the human in organizations, there is still much room for improvement. Focus in the reduction of employee injuries such as cumulative trauma disorders rose in the 80 s. Attempts at increasing performance by addressing employee satisfaction through various methods have also been ongoing for several years now. Knowledge Management is one of the most recent attempts at controlling and making the best use of
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5

Yang, Chao. "Tissue engineering of human cardiovascular patches." [S.l.] : [s.n.], 2005. http://www.diss.fu-berlin.de/2005/103/yang.pdf.

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6

Junker, Johan. "Human Dermal Fibroblasts in Tissue Engineering." Doctoral thesis, Linköpings universitet, Cellbiologi, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-19716.

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The loss or failure of tissues and/or organs is one of the most frequent problems in modern healthcare. The field of tissue engineering applies the principles of biology and engineering in order to develop functional substitutes for damaged tissues. Tissue engineering contains elements of medicine, material science and engineering with major components in focus being cells, biomaterials and soluble factors. All three components may be required for the development of clinical treatments. The usage of autologous tissue specific cells for clinical treatment is often not feasible due to poor growt
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7

Heller, Raoul. "Engineering of human artificial mini-chromosomes." Thesis, University of Oxford, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.360317.

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8

Hughes, Paul Edward. "Protein engineering of human factor IX." Thesis, University of Oxford, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.306171.

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9

Weber, Matthew Charles. "Engineering human bone marrow stromal cells." Case Western Reserve University School of Graduate Studies / OhioLINK, 1991. http://rave.ohiolink.edu/etdc/view?acc_num=case1055867071.

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10

Junker, Johan P. E. "Human dermal fibroblasts in tissue engineering /." Linköping : Department of Clinical and Experimental Medicine, Linköping University, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-19716.

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11

Haug, Knut Hallvard Sverre. "Engineering humans : cultural history of the science and technology of human enhancement." Thesis, Birkbeck (University of London), 2016. http://bbktheses.da.ulcc.ac.uk/210/.

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This thesis investigates the technological imaginary of human enhancement: how it has been conceived historically and the scientific understanding that has shaped it. Human enhancement technologies have been prominent in popular culture narratives for a long time, but in the past twenty years they have moved out of science fiction to being an issue for serious discussion, in academic disciplines, political debate and the mass media. Even so, the bioethical debate on enhancement, whether it is pharmacological means of improving cognition and morality or genetic engineering to create smarter peo
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12

Sloot, Albert Martinus van der. "Design and engineering of human TRAIL variants." [S.l. : [Groningen : s.n.] ; University Library Groningen] [Host], 2006. http://irs.ub.rug.nl/ppn/298508133.

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13

Lohmueller, Jason Jakob. "Synthetic Biology Approaches to Engineering Human Cells." Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:11030.

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The field of synthetic biology seeks to revolutionize the scope and scale of what is currently feasible by genetic engineering. By focusing on engineering general signal processing platforms using modular genetic parts and devices rather than `one-off' systems, synthetic biologists aim to enable plug-and-play genetic circuits readily adaptable to different contexts. For mammalian systems, the goal of synthetic biology is to create sophisticated research tools and gene therapies. While several isolated parts and devices exist for mammalian systems there are few signal processing platforms avail
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14

Galvin, Lawrence Francis. "Human factors engineering in sonar visual displays." Thesis, Springfield, Virginia: Available from National Technical Information Service, 1991. http://hdl.handle.net/10945/28265.

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15

Pallotta, Vincenzo. "Cognitive language engineering towards robust human-computer interaction /." Lausanne, 2002. http://library.epfl.ch/theses/?display=detail&nr=2630.

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16

Lentz, Albrecht. "Acceptability of civil engineering decisions involving human consequences." [S.l.] : [s.n.], 2007. http://mediatum2.ub.tum.de/doc/618431/document.pdf.

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17

Kinikoglu, Beste F. "Tissue Engineering Of Full-thickness Human Oral Mucosa." Phd thesis, METU, 2010. http://etd.lib.metu.edu.tr/upload/12612770/index.pdf.

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Tissue engineered human oral mucosa has the potential to fill tissue deficits caused by facial trauma or malignant lesion surgery. It can also help elucidate the biology of oral mucosa and serve as an alternative to in vivo testing of oral care products. The aim of this thesis was to construct a tissue engineered full-thickness human oral mucosa closely mimicking the native tissue. To this end, the feasibility of the concept was tested by co-culturing fibroblasts and epithelial cells isolated from normal human oral mucosa biopsies in a collagen-glycosaminoglycan-chitosan scaffold, developed in
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18

Rust, Philippa Ann. "Human mesenchymal stem cells for tissue engineering bone." Thesis, University College London (University of London), 2003. http://discovery.ucl.ac.uk/1383233/.

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My thesis hypothesises that cells isolated from human bone marrow could be stimulated to differentiate into osteoblasts and that, these cells when cultured on a scaffold could be used in the tissue engineering of bone, as the constructs could potentially be implanted into patients' bone defects resulting in increased healing. The multipotency of the bone marrow-isolated cells was assessed by the use of histological stains to show that they could be stimulated to differentiate into osteoblasts, chondrocytes and adipocytes. The cells were further characterised by Stro- 1 and, as a result, were d
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19

Abujaafar, Khalifa Mohamed. "Quantitative human reliability assessment in marine engineering operations." Thesis, Liverpool John Moores University, 2012. http://researchonline.ljmu.ac.uk/6115/.

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Marine engineering operations rely substantially on high degrees of automation and supervisory control. This brings new opportunities as well as the threat of erroneous human actions, which account for 80-90% of marine incidents and accidents. In this respect, shipping environments are extremely vulnerable. As a result, decision makers and stakeholders have zero tolerance for accidents and environmental damage, and require high transparency on safety issues. The aim of this research is to develop a novel quantitative Human Reliability Assessment (HRA) methodology using the Cognitive Reliabilit
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20

Kinikoglu, Fatma Beste. "Tissue engineering of full-thickness human oral mucosa." Thesis, Lyon 1, 2010. http://www.theses.fr/2010LYO10310.

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L’ingénierie de la muqueuse orale humaine (MOH) a pour but le comblement des pertes de substances suite à un traumatisme facial ou à la chirurgie des lésions malignes. Elle a aussi des applications en recherche pour élucider les mécanismes biologiques de la MO et en pharmacotoxicologie comme alternative à l’expérimentation animale. L'objectif de cette thèse était de reconstruire une MOH proche du tissu normal. À cette fin, la faisabilité du concept a d'abord été testée par co-culture de fibroblastes de la lamina propria et de cellules épithéliales de MOH dans le substrat de collagène-chitosan
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21

Liu, Hongjuan. "Recombinant Human Tropoelastin as Biomaterial for Tissue Engineering." Thesis, The University of Sydney, 2015. http://hdl.handle.net/2123/15334.

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Polymeric biomaterials are widely used as long-term implantable materials for tissue replacement and repair. However, many classes of material are limited as they elicit an uncontrolled foreign body response. Recombinant human tropoelastin is a biocompatible biomaterial that may be able to overcome current challenges facing tissue engineering. The aim of current studies is to investigate the host responses to these three different materials: silk, polyurethane Elast-Eon and low density polyethylene with tropoelastin employed as a co-polymer or surface coating in vivo. We demonstrated that all
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22

PASQUALI, DARIO. "Social Engineering Defense Solutions Through Human-Robot Interaction." Doctoral thesis, Università degli studi di Genova, 2022. http://hdl.handle.net/11567/1092333.

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Social Engineering is the science of using social interaction to influence others on taking computer-related actions of attacker’s interest. It is used to steal credentials, money, or people’s identities. After being left unchecked for a long time, social engineering is raising increasing concerns. Despite its social nature, state-of-the-art defense systems mainly focus on engineering factors. They detect technical features specific to the medium employed in the attack (e.g., phishing emails), or they train final users on detecting them. However, the crucial aspects of social engineering ar
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23

Dodhia, Vikash Rajnikant. "Engineering human cytochrome P450s for structural and biosensing studies." Thesis, Imperial College London, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.429524.

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24

Al-Hazaimeh, Nawaf Ismail. "Revascularization of human dental pulp using tissue engineering approaches." Thesis, University of Leeds, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.582741.

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Advancement in stem cell technology allows for many therapeutic opportunities, including the treatment of previously intractable conditions. Revascularization of dental pulp tissue, and specifically angiogenic differentiation of Human Dental Pulp Stem Cells, is of great interest due to the crucial role of this process not only in dental pulp regeneration, but also in wound healing and in regenerative medicine in general. One of the challenges of tissue engineering is the ability to provide sufficient blood supply for engineered tissue and organs in the first phase after transplantation. The pr
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25

Yang, Xuebin. "Bone tissue engineering : biomimetic structures for human osteoprogenitor growth." Thesis, University of Southampton, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270664.

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26

Ng, Shengyong. "Engineering human hepatic tissue for modeling liver-stage malaria." Thesis, Massachusetts Institute of Technology, 2014. http://hdl.handle.net/1721.1/90150.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biological Engineering, 2014.<br>Cataloged from PDF version of thesis. Vita.<br>Includes bibliographical references (pages 132-153).<br>The Plcsmodium liver stage is an attractive target for the development of antimalarial drugs and vaccines, as it provides an opportunity to interrupt the life cycle of the parasite at a critical early stage. However, targeting the liver stage has been difficult due to a lack of human liver models that robustly recapitulate host-pathogen interactions in a physiologically relevant cell type. Th
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27

Savoie, Troy Brendon. "Human detection of computer simulation mistakes in engineering experiments." Thesis, Massachusetts Institute of Technology, 2010. http://hdl.handle.net/1721.1/61526.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2010.<br>This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.<br>Cataloged from student-submitted PDF version of thesis.<br>Includes bibliographical references (p. 97-104).<br>This thesis investigates the notion that the more complex the experimental plan, the less likely an engineer is to discover a simulation mistake in a computer-based experiment. The author used an in vitro methodology to conduct an experiment
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28

Perli, Samuel David. "An integrated CRISPR-Cas toolkit for engineering human cells." Thesis, Massachusetts Institute of Technology, 2015. http://hdl.handle.net/1721.1/99781.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2015.<br>This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.<br>Cataloged from student-submitted PDF version of thesis.<br>Includes bibliographical references (pages 145-158).<br>Natively functioning Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-associated (Cas) system is a prokaryotic adaptive immune system that confers resistance to foreign genetic elements includin
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29

Lieder, Falk. "Beyond Bounded Rationality| Reverse-Engineering and Enhancing Human Intelligence." Thesis, University of California, Berkeley, 2018. http://pqdtopen.proquest.com/#viewpdf?dispub=10817569.

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<p> Bad decisions can have devastating consequences, and there is a vast body of literature suggesting that human judgment and decision-making are riddled with numerous systematic violations of the rules of logic, probability theory, and expected utility theory. The discovery of these <i>cognitive biases</i> in the 1970s challenged the concept of Homo sapiens as the rational animal and has profoundly shaken the foundations of economics and rational models in the cognitive, neural, and social sciences. Four decades later, these disciplines still lack a rigorous theoretical foundation that can a
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30

Nguyen, Le Thanh Tu. "Engineering the human gut microbiome through personalized dietary interventions." Thesis, Massachusetts Institute of Technology, 2020. https://hdl.handle.net/1721.1/130187.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biological Engineering, May, 2020<br>Cataloged from student-submitted PDF version of thesis.<br>Includes bibliographical references.<br>The human gastrointestinal tract is home to a dense and dynamic microbial community. The composition and metabolic output of the human gut microbiota have been implicated in many diseases: from inflammatory bowel disease, colorectal cancer, and diarrheal diseases to metabolic syndromes like diabetes. Treatment of these diseases will likely require targeted therapeutic interventions aimed at m
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31

DePalatis, Laura. "Engineering for Improved Folding of a Human Prolactin Antagonist." The Ohio State University, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=osu1392968846.

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32

Kim, Kyungbo. "CHARACTERIZATION AND ENGINEERING OF HUMAN PROTEINS AS THERAPEUTIC CANDIDATES." UKnowledge, 2018. https://uknowledge.uky.edu/pharmacy_etds/91.

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Protein engineering has been a useful tool in the fight against human diseases. Human insulin was the first recombinant DNA-derived therapeutic protein (Humulin®) approved by the US FDA in 1982. However, many of the early protein drugs were only recombinant versions of natural proteins with no modification of their primary amino acid sequence and most of them did not make optimal drug products mainly due to their short half-life or suboptimal affinity, leading to poor therapeutic efficacy. The difficulty in the large-scale production of some therapeutic proteins was another important issue. In
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33

AROYO, ALEXANDER MOIS. "Bringing Human Robot Interaction towards _Trust and Social Engineering." Doctoral thesis, Università degli studi di Genova, 2019. http://hdl.handle.net/11567/940915.

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Robots started their journey in books and movies; nowadays, they are becoming an important part of our daily lives: from industrial robots, passing through entertainment robots, and reaching social robotics in fields like healthcare or education. An important aspect of social robotics is the human counterpart, therefore, there is an interaction between the humans and robots. Interactions among humans are often taken for granted as, since children, we learn how to interact with each other. In robotics, this interaction is still very immature, however, critical for a successful incorporati
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34

Trammell, Melanie Kaye. "Complexity of Engineering Identity: A Study of Freshmen Engineering Students." Thesis, Virginia Tech, 2019. http://hdl.handle.net/10919/91464.

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The General Engineering Program exists at Virginia Tech to provide curriculums that engage, challenge and support entry-level engineers. One important part of this initiative is helping students identify with a specific engineering branch, and overtime develop an identity within it. Yet, there exists little research on what entry-level engineers believe it means to be an engineer, especially during these stages of early formation and continual shifting. In order to generate insight on this topic we developed a contextual inquiry method to help inquire into engineering identity. Two participant
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35

Richardson, Andrew Xenos. "Evaluating Human-Robot Implicit Communication through Human-Human Implicit Communication." Doctoral diss., University of Central Florida, 2012. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/5457.

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Human-Robot Interaction (HRI) research is examining ways to make human-robot (HR) communication more natural. Incorporating natural communication techniques is expected to make HR communication seamless and more natural for humans. Humans naturally incorporate implicit levels of communication, and including implicit communication in HR communication should provide tremendous benefit. The aim for this work was to evaluate a model for human-robot implicit communication. Specifically, the primary goal for this research was to determine whether humans can assign meanings to implicit cues received
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36

Klein, Alex C. (Alex Charles). "Whole human design : designing for Humans, not Users." Thesis, Massachusetts Institute of Technology, 2018. https://hdl.handle.net/1721.1/122887.

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Thesis: S.M. in Engineering and Management, Massachusetts Institute of Technology, System Design and Management Program, 2018<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (pages 134-136).<br>In the past ten years, the Human-Centered Design methodology has exploded--permeating our organizational and academic worlds and becoming one of the most sought-after skills. The user-first mantra has become widely accepted and internalized. Develop empathy! Find users in their natural habitat! Design for their needs, not yours! Despite its vast popularity, I believe ther
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37

Murphy, Philippa. "Analyses of communication failures in rail engineering works." Thesis, University of Nottingham, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.275298.

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38

Huynh, Kien Khanh. "Human Thermal Comfort." MSSTATE, 2001. http://sun.library.msstate.edu/ETD-db/theses/available/etd-04092001-135104/.

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The purpose of this research is to investigate human comfort criteria under steady-state conditions as a function of ambient air temperature, mean radiant temperature, relative humidity, air velocity, level of activity, and clothing insulation. Since the current ASHRAE Standard 55-1994 is for sedentary activity, this study will consider relative humidity (20% to 65%), dry bulb temperature (73 oF to 82 oF), air velocity (30 fpm and 50 fpm), and sedentary-to-moderate activity. The mean radiant temperature will be taken to be the same as the ambient air temperature. The experimental results colle
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39

Sasso, R. "A new approach to user interface engineering." Thesis, University of Oxford, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.371578.

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40

Ali, Syed. "Towards Human-Like Automated Driving| Learning Spacing Profiles from Human Driving Data." Thesis, Wayne State University, 2017. http://pqdtopen.proquest.com/#viewpdf?dispub=10637971.

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<p> For automated driving vehicles to be accepted by their users and safely integrate with traffic involving human drivers, they need to act and behave like human drivers. This not only involves understanding how the human driver or occupant in the automated vehicle expects their vehicle to operate, but also involves how other road users perceive the automated vehicle&rsquo;s intentions. This research aimed at learning how drivers space themselves while driving around other vehicles. It is shown that an optimized lane change maneuver does create a solution that is much different than what a hu
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41

Cunningham, Hamish. "Software architecture for language engineering." Thesis, University of Sheffield, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.324440.

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42

Philippart, Monica F. "Improving business performance through the integration of human factors engineering into organizations using a systems engineering approach." Orlando, Fla. : University of Central Florida, 2008. http://purl.fcla.edu/fcla/etd/CFE0002445.

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43

Sommar, Pehr. "Differentiation of Human Dermal Fibroblasts and Applications in Tissue Engineering." Doctoral thesis, Linköpings universitet, Hand och plastikkirurgi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-60879.

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Tissue engineering applies principles of biology and engineering to the development of functional substitutes for damaged or lost tissues. Tools for the neo-generation of tissue in tissue engineering research include cells, biomaterials and soluble factors. One main obstacle in tissue engineering is the limited availability of autologous tissue specific progenitor cells. This has led to interest into using autologous cells with stem cell plasticity. Bone marrow derived stem cells were the first adult stem cells shown to have multilineage potential. Since, several reports have been published in
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44

Abdelmouti, Mai Mohamed Medhat Abdelhalim. "Engineering a genetically relevant zebrafish model of human uveal melanoma." Thesis, University of Manchester, 2016. https://www.research.manchester.ac.uk/portal/en/theses/engineering-a-genetically-relevant-zebrafish-model-of-human-uveal-melanoma(6bc6f02b-8d80-4e6e-bc5b-72fab73b0788).html.

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Uveal melanoma (UM) is a sight and life-threatening malignancy of the human eye. The potential for progress in translational UM research is, however, hampered by the short supply of clinical samples due to its rarity and also the lack of an informative animal model which would allow experimental intervention to dissect the molecular machinery governing tumor development. Towards this end, we aimed to generate a genetically relevant model of human UM in zebrafish that can be used to study the roles of key genetic determinants in tumor initiation and progression in vivo and also establish a valu
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Shahin, Kifah Biotechnology &amp Biomolecular Sciences Faculty of Science UNSW. "In vitro production of human hyaline cartilage using tissue engineering." Publisher:University of New South Wales. Biotechnology & Biomolecular Sciences, 2008. http://handle.unsw.edu.au/1959.4/42945.

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Articular cartilage disorders are a leading cause of human disability in many countries around the world. In this work, new techniques and strategies were developed to improve the quality of cartilage produced in vitro by methods of tissue engineering. Chondrocytes were isolated from the hip and knee joints of aborted human foetuses. The cells were expanded and seeded into scaffolds and the seeded scaffolds were cultured in perfusion bioreactors. The quality of the final cartilage constructs was assessed biochemically by measuring their content of glycosaminoglycan (GAG), total collagen and co
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46

Xia, Zhidao. "Potentials for bone tissue engineering using human mesenchymal stem cells." Thesis, University of Oxford, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.418129.

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47

Holmes, L. R. "Chromosomal engineering to produce a model of human 5q-syndrome." Thesis, University of Cambridge, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.604181.

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Initial chromosomal engineering has been undertaken on the syntenic region of mouse chromosome 11. Chromosomal deletions were generated using <i>Cre-loxP </i>technology.  A primary <i>loxP </i>site was inserted at a determined anchor point, the <i>sparc </i>gene, present within the syntenic region identified on chromosome 11. Deletions were then created in ES cells following the insertion of a second <i>loxP </i>site into the same <i>copy </i>of chromosome 11, either using a random integration strategy or a defined targeting methodology, and the expression of Cre recombinase. A defined deletio
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48

Fung, Leung Pik-wah, and 梁碧華. "Strategic human resources management in a civil engineering/construction company." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1991. http://hub.hku.hk/bib/B31264906.

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49

Howard, Daniel. "Orthopaedic tissue engineering utilising immuno-selected human mesenchymal stem cells." Thesis, University of Southampton, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.398731.

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50

Chao, Chung-Yun(Chung-Yun George). "Engineering of tools for De Novo Assembly of Human Cells." Thesis, Massachusetts Institute of Technology, 2020. https://hdl.handle.net/1721.1/130205.

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Thesis: Ph. D. in Medical Engineering and Medical Physics, Harvard-MIT Program in Health Sciences and Technology, September, September, 2020<br>Cataloged from student-submitted PDF version of thesis.<br>Includes bibliographical references.<br>Organs for transplantation has continuously been in short supply and, given COVID-19's propensity to adversely impact solid organs, the shortage will likely become exacerbated. For decades, the field of tissue engineering has developed innovative methods to generate model tissues de novo. Top-down approaches, such as microfluidics and 3D bioprinting, prov
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