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Journal articles on the topic 'Human herpesviruses'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Kutle, Ivana, Anne Dittrich, and Dagmar Wirth. "Mouse Models for Human Herpesviruses." Pathogens 12, no. 7 (2023): 953. http://dx.doi.org/10.3390/pathogens12070953.

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More than one hundred herpesviruses have been isolated from different species so far, with nine infecting humans. Infections with herpesviruses are characterized by life-long latency and represent a significant challenge for human health. To investigate the consequences of infections and identify novel treatment options, in vivo models are of particular relevance. The mouse has emerged as an economical small animal model to investigate herpesvirus infections. However, except for herpes simplex viruses (HSV-1, HSV-2), human herpesviruses cannot infect mice. Three natural herpesviruses have been

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2

Bouchemal, Amina, Joan Martí Carreras, Lydia Khireddine, et al. "Investigation on colorectal cancer and human herpesvirus infection among Algerian patients." Journal of Infection in Developing Countries 17, no. 05 (2023): 656–64. http://dx.doi.org/10.3855/jidc.17640.

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Introduction: Herpesviruses are a widespread family of double-stranded DNA viruses that establish life-long persistent infection in their hosts. Cumulative evidence tends to argue for the association of human herpesviruses, such as Kaposi's sarcoma herpesvirus (KHSV), Epstein-Barr virus (EBV), and human cytomegalovirus (HCMV) with various human disorders and diseases. The present study aims to investigate the presence of herpesviruses in colorectal cancer (CRC). Methodology: We investigated the presence of herpesviruses in 69 formalin-fixed paraffin embedded tissue (FFPE) biopsies, using a pan

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Hassan, Sherif T. S., Miroslava Šudomová, Alena Mazurakova, and Peter Kubatka. "Insights into Antiviral Properties and Molecular Mechanisms of Non-Flavonoid Polyphenols against Human Herpesviruses." International Journal of Molecular Sciences 23, no. 22 (2022): 13891. http://dx.doi.org/10.3390/ijms232213891.

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Herpesviruses are one of the most contagious DNA viruses that threaten human health, causing severe diseases, including, but not limited to, certain types of cancer and neurological complications. The overuse and misuse of anti-herpesvirus drugs are key factors leading to drug resistance. Therefore, targeting human herpesviruses with natural products is an attractive form of therapy, as it might improve treatment efficacy in therapy-resistant herpesviruses. Plant polyphenols are major players in the health arena as they possess diverse bioactivities. Hence, in this article, we comprehensively

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Chen, Siyu, Yue Deng, and Dongli Pan. "MicroRNA Regulation of Human Herpesvirus Latency." Viruses 14, no. 6 (2022): 1215. http://dx.doi.org/10.3390/v14061215.

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Herpesviruses are ubiquitous human pathogens. After productive (lytic) infection, all human herpesviruses are able to establish life-long latent infection and reactivate from it. Latent infection entails suppression of viral replication, maintenance of the viral genome in infected cells, and the ability to reactivate. Most human herpesviruses encode microRNAs (miRNAs) that regulate these processes during latency. Meanwhile, cellular miRNAs are hijacked by herpesviruses to participate in these processes. The viral or cellular miRNAs either directly target viral transcripts or indirectly affect

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Nazaryan, R. S., Yu V. Fomenko, N. A. Scheblykina, T. A. Kolesova, N. V. Golik, and E. V. Sukhostavets. "Herpesviruses. Part 1." Ukraïnsʹkij žurnal medicini, bìologìï ta sportu 5, no. 6 (2020): 299–307. http://dx.doi.org/10.26693/jmbs05.06.299.

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One of the urgent problems of modern medicine is the high incidence of herpesvirus infections. The high prevalence of herpesviruses in the human population of the world allow us to consider herpes a common systemic disease of the whole organism. Doctors of any specialty are faced with the clinical manifestations of herpes infection in patients, and they themselves are a risk group of chronic herpes infections formation due to constant patient contacts and frequent professional psycho-emotional overload. Herpes infections are a group of infectious diseases caused by human herpesviruses. Now it

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Bharucha, Tehmina, Catherine F. Houlihan, and Judith Breuer. "Herpesvirus Infections of the Central Nervous System." Seminars in Neurology 39, no. 03 (2019): 369–82. http://dx.doi.org/10.1055/s-0039-1687837.

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AbstractThere are over 200 herpesvirus species, of which 10 affect humans. Each of these 10 herpesviruses has a unique clinical syndrome, but common to all is their ability to cause infection and pathology in the central nervous system. In this article, we discuss the epidemiology, clinical presentation, diagnostic modalities, treatment, sequelae, and availability of vaccination of each of the following herpesviruses: herpes simplex virus 1 and 2, varicella zoster virus, human cytomegalovirus, human herpesvirus 6A, 6B, and 7, Epstein–Barr virus, human herpesvirus 8, and simian herpesvirus B.

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Pontejo, Sergio M., Philip M. Murphy, and James E. Pease. "Chemokine Subversion by Human Herpesviruses." Journal of Innate Immunity 10, no. 5-6 (2018): 465–78. http://dx.doi.org/10.1159/000492161.

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Viruses use diverse molecular mechanisms to exploit and evade the immune response. Herpesviruses, in particular, encode functional chemokine and chemokine receptor homologs pirated from the host, as well as secreted chemokine-binding proteins with unique structures. Multiple functions have been described for herpesvirus chemokine components, including attraction of target cells, blockade of leukocyte migration, and modulation of gene expression and cell entry by the virus. Here we review current concepts about how human herpesvirus chemokines, chemokine receptors, and chemokine-binding protein

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Rickinson, Alan. "Concluding overview: looking back, looking forward." Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences 356, no. 1408 (2001): 595–604. http://dx.doi.org/10.1098/rstb.2000.0785.

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The γ–herpesviruses are a group of related agents which share the same broad strategy for infection of and persistence within the lymphoid tissues of their hosts. Yet in evolutionary terms these agents are sufficiently diverse to display multiple different molecular mechanisms whereby that strategy can be achieved. Attempts are made to relate the different in vitro growth transforming capacities of the γ 1 –herpesviruses, the T–lymphotropic γ 2 –herpesviruses and the B–lymphotropic γ 2 –herpesviruses to what is known about the biology of these virus infections in their natural or in experiment

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9

Yamanishi, Koichi. "New human herpesviruses; human herpesvirus 6 and 7." Clinical Biochemistry 28, no. 3 (1995): 348. http://dx.doi.org/10.1016/0009-9120(95)91425-3.

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Kamel, Mohamed S., Rachel A. Munds, and Mohit S. Verma. "The Quest for Immunity: Exploring Human Herpesviruses as Vaccine Vectors." International Journal of Molecular Sciences 24, no. 22 (2023): 16112. http://dx.doi.org/10.3390/ijms242216112.

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Herpesviruses are large DNA viruses that have long been used as powerful gene therapy tools. In recent years, the ability of herpesviruses to stimulate both innate and adaptive immune responses has led to their transition to various applications as vaccine vectors. This vaccinology branch is growing at an unprecedented and accelerated rate. To date, human herpesvirus-based vectors have been used in vaccines to combat a variety of infectious agents, including the Ebola virus, foot and mouth disease virus, and human immunodeficiency viruses. Additionally, these vectors are being tested as potent

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Xie, Chu, Xin-Yan Fang, Yuan-Tao Liu, et al. "Human herpesvirus 6B glycoprotein B postfusion structure, vulnerability mapping, and receptor recognition." PLOS Pathogens 21, no. 7 (2025): e1013300. https://doi.org/10.1371/journal.ppat.1013300.

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Human herpesvirus 6B (HHV-6B), a β-herpesvirus that significantly threatens immunocompromised individuals, currently lacks targeted antiviral therapies or vaccines. Glycoprotein B (gB), the primary mediator of membrane fusion during viral entry, is a key target for neutralizing antibody (nAb) and vaccine development. In this study, we determined a 2.8 Å cryo-EM structure of the HHV-6B gB ectodomain in its postfusion conformation, unveiling unique N-terminal features and resolving the furin site for the first time in herpesviruses. Comparative analyses highlighted similarities between HHV-6B gB

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Boivin, Guy. "Recent Developments in Viral Load Measurements in Human Herpesviruses." Canadian Journal of Infectious Diseases 10, suppl c (1999): 33C—40C. http://dx.doi.org/10.1155/1999/965245.

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Recent developments in molecular biology have allowed precise quantitative analysis of herpesvirus DNA in many biological fluids. Th is paper reviews the clinical utility of performing quantitative polymerase chain reaction testing for herpesviruses. In particular, the assessment of the cytomegalovirus (CMV) DNA load in blood with regard to the development of CMV disease in immunocompromised patients is discussed in greater detail. Relevant information exists to support measuring the CMV burden in the blood of AIDS and transplant patients for diagnostic and treatment monitoring purposes, and,

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Šudomová, Miroslava, Kateřina Berchová-Bímová, Alena Mazurakova, Dunja Šamec, Peter Kubatka, and Sherif T. S. Hassan. "Flavonoids Target Human Herpesviruses That Infect the Nervous System: Mechanisms of Action and Therapeutic Insights." Viruses 14, no. 3 (2022): 592. http://dx.doi.org/10.3390/v14030592.

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Human herpesviruses (HHVs) are large DNA viruses with highly infectious characteristics. HHVs can induce lytic and latent infections in their host, and most of these viruses are neurotropic, with the capacity to generate severe and chronic neurological diseases of the peripheral nervous system (PNS) and central nervous system (CNS). Treatment of HHV infections based on strategies that include natural products-derived drugs is one of the most rapidly developing fields of modern medicine. Therefore, in this paper, we lend insights into the recent advances that have been achieved during the past

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Houldcroft, Charlotte J. "Human Herpesvirus Sequencing in the Genomic Era: The Growing Ranks of the Herpetic Legion." Pathogens 8, no. 4 (2019): 186. http://dx.doi.org/10.3390/pathogens8040186.

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The nine human herpesviruses are some of the most ubiquitous pathogens worldwide, causing life-long latent infection in a variety of different tissues. Human herpesviruses range from mild childhood infections to known tumour viruses and ‘trolls of transplantation’. Epstein-Barr virus was the first human herpesvirus to have its whole genome sequenced; GenBank now includes thousands of herpesvirus genomes. This review will cover some of the recent advances in our understanding of herpesvirus diversity and disease that have come about as a result of new sequencing technologies, such as target enr

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Petrini, Stefano, and Peter Maple. "Herpesvirus Vaccines." Vaccines 10, no. 4 (2022): 628. http://dx.doi.org/10.3390/vaccines10040628.

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Yu, Xuekui, Jonathan Jih, Jiansen Jiang, and Z. Hong Zhou. "Atomic structure of the human cytomegalovirus capsid with its securing tegument layer of pp150." Science 356, no. 6345 (2017): eaam6892. http://dx.doi.org/10.1126/science.aam6892.

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Herpesviruses possess a genome-pressurized capsid. The 235-kilobase genome of human cytomegalovirus (HCMV) is by far the largest of any herpesvirus, yet it has been unclear how its capsid, which is similar in size to those of other herpesviruses, is stabilized. Here we report a HCMV atomic structure consisting of the herpesvirus-conserved capsid proteins MCP, Tri1, Tri2, and SCP and the HCMV-specific tegument protein pp150—totaling ~4000 molecules and 62 different conformers. MCPs manifest as a complex of insertions around a bacteriophage HK97 gp5–like domain, which gives rise to three classes

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Tognarelli, Eduardo I., Antonia Reyes, Nicolás Corrales, et al. "Modulation of Endosome Function, Vesicle Trafficking and Autophagy by Human Herpesviruses." Cells 10, no. 3 (2021): 542. http://dx.doi.org/10.3390/cells10030542.

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Human herpesviruses are a ubiquitous family of viruses that infect individuals of all ages and are present at a high prevalence worldwide. Herpesviruses are responsible for a broad spectrum of diseases, ranging from skin and mucosal lesions to blindness and life-threatening encephalitis, and some of them, such as Kaposi’s sarcoma-associated herpesvirus (KSHV) and Epstein–Barr virus (EBV), are known to be oncogenic. Furthermore, recent studies suggest that some herpesviruses may be associated with developing neurodegenerative diseases. These viruses can establish lifelong infections in the host

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Odom, Carl I., David C. Gaston, James M. Markert, and Kevin A. Cassady. "Human Herpesviridae Methods of Natural Killer Cell Evasion." Advances in Virology 2012 (2012): 1–10. http://dx.doi.org/10.1155/2012/359869.

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Human herpesviruses cause diseases of considerable morbidity and mortality, ranging from encephalitis to hematologic malignancies. As evidence emerges about the role of innate immunity and natural killer (NK) cells in the control of herpesvirus infection, evidence of viral methods of innate immune evasion grows as well. These methods include interference with the ligands on infected cell surfaces that bind NK cell activating or inhibitory receptors. This paper summarizes the most extensively studied NK cell receptor/ligand pairs and then describes the methods of NK cell evasion used by all eig

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Agut, Henri, Nicolas Dupin, Jean-Thierry Aubin, and Vincent Calvez. "Novel human herpesviruses (human herpesviruses 6, 7 and 8)." Clinical Microbiology and Infection 2, no. 3 (1996): 159–67. http://dx.doi.org/10.1016/s1198-743x(14)65138-7.

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Sánchez-Ponce, Yessica, Gustavo Varela-Fascinetto, José Romo-Vázquez, et al. "Simultaneous Detection of Beta and Gamma Human Herpesviruses by Multiplex qPCR Reveals Simple Infection and Coinfection Episodes Increasing Risk for Graft Rejection in Solid Organ Transplantation." Viruses 10, no. 12 (2018): 730. http://dx.doi.org/10.3390/v10120730.

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Herpesviruses are common components of the human microbiome that become clinically relevant when a competent immunosurveillance is compromised, such as in transplantation. Members of the beta and gamma subfamilies are associated with a wide diversity of pathologies, including end-organ disease and cancer. In this study, we developed a multiplex qPCR technique with high specificity, sensitivity, efficiency and predictability that allowed the simultaneous detection and quantification of beta and gamma human herpesviruses. The technique was tested in a cohort of 34 kidney- or liver-transplanted p

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Damania, Blossom, and Ronald C. Desrosiers. "Simian homologues of human herpesvirus 8." Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences 356, no. 1408 (2001): 535–43. http://dx.doi.org/10.1098/rstb.2000.0782.

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γ–Herpesviruses can be found in most primates including Old World an New World monkeys. The γ– herpesvirinae are grouped into two classes: lymphocryptoviruses (γ 1 ) and rhadinoviruses (γ 2 ). The lymphocryptoviruses include Epstein–Barr virus, lymphocryptovirus of rhesus monkeys, and Herpesvirus papio of baboons. Rhadinoviruses that infect New World monkeys include Herpesvirus saimiri , whose natural host is the squirrel monkey, and Herpesvirus ateles , which infects spider monkeys. Rhadinoviruses that infect hominoids and Old World monkeys include Kaposi's sarcoma–associated herpesvirus, als

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Lacoste, Vincent, Philippe Mauclere, Guy Dubreuil, et al. "Simian Homologues of Human Gamma-2 and Betaherpesviruses in Mandrill and Drill Monkeys." Journal of Virology 74, no. 24 (2000): 11993–99. http://dx.doi.org/10.1128/jvi.74.24.11993-11999.2000.

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ABSTRACT Recent serological and molecular surveys of different primate species allowed the characterization of several Kaposi's sarcoma-associated herpesvirus (KSHV) homologues in macaques, African green monkeys, chimpanzees, and gorillas. Identification of these new primate rhadinoviruses revealed the existence of two distinct genogroups, called RV1 and RV2. Using a degenerate consensus primer PCR method for the herpesvirus DNA polymerase gene, the presence of KSHV homologues has been investigated in two semi-free-ranging colonies of eight drill (Mandrillus leucophaeus), five mandrill (Mandri

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Vider-Shalit, Tal, Vered Fishbain, Shai Raffaeli, and Yoram Louzoun. "Phase-Dependent Immune Evasion of Herpesviruses." Journal of Virology 81, no. 17 (2007): 9536–45. http://dx.doi.org/10.1128/jvi.02636-06.

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ABSTRACT Viruses employ various modes to evade immune detection. Two possible evasion modes are a reduction of the number of epitopes presented and the mimicry of host epitopes. The immune evasion efforts are not uniform among viral proteins. The number of epitopes in a given viral protein and the similarity of the epitopes to host peptides can be used as a measure of the viral attempts to hide this protein. Using bioinformatics tools, we here present a genomic analysis of the attempts of four human herpesviruses (herpes simplex virus type 1-human herpesvirus 1, Epstein-Barr virus-human herpes

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Minjolle, Sophie, C. Michelet, I. Jusselin, M. Joannes, F. Cartier, and R. Colimon. "Amplification of the Six Major Human Herpesviruses from Cerebrospinal Fluid by a Single PCR." Journal of Clinical Microbiology 37, no. 4 (1999): 950–53. http://dx.doi.org/10.1128/jcm.37.4.950-953.1999.

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We used a novel type of primer system, a system that uses stair primers, in which the primer sequences are based on consensus sequences in the DNA polymerase gene of herpesvirus to detect herpesviruses by PCR. A single PCR in a single tube detected the six major herpesviruses that infect the central nervous system: herpes simplex virus type 1 (HSV-1), and type 2 (HSV-2), cytomegalovirus (CMV), Epstein-Barr virus (EBV), varicella-zoster virus (VZV), and human herpesvirus 6 (HHV-6). We used the technique to analyze 142 cerebrospinal fluid (CSF) samples that had been stored at −80°C and compared

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de Souza Carneiro, Vanessa Cristine, Luciane Almeida Amado Leon, and Vanessa Salete de Paula. "miRNAs: Targets to Investigate Herpesvirus Infection Associated with Neurological Disorders." International Journal of Molecular Sciences 24, no. 21 (2023): 15876. http://dx.doi.org/10.3390/ijms242115876.

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Herpesvirus is associated with various neurological disorders and a specific diagnosis is associated with a better prognosis. MicroRNAs (miRNAs) are potential diagnostic and prognostic biomarkers of neurological diseases triggered by herpetic infection. In this review, we discuss miRNAs that have been associated with neurological disorders related to the action of herpesviruses. Human miRNAs and herpesvirus-encoded miRNAs were listed and discussed. This review article will be valuable in stimulating the search for new diagnostic and prognosis alternatives and understanding the role of these mi

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Šudomová, Miroslava, Kateřina Berchová-Bímová, Stefania Marzocco, Alena Liskova, Peter Kubatka, and Sherif T. S. Hassan. "Berberine in Human Oncogenic Herpesvirus Infections and Their Linked Cancers." Viruses 13, no. 6 (2021): 1014. http://dx.doi.org/10.3390/v13061014.

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Human herpesviruses are known to induce a broad spectrum of diseases, ranging from common cold sores to cancer, and infections with some types of these viruses, known as human oncogenic herpesviruses (HOHVs), can cause cancer. Challenges with viral latency, recurrent infections, and drug resistance have generated the need for finding new drugs with the ability to overcome these barriers. Berberine (BBR), a naturally occurring alkaloid, is known for its multiple biological activities, including antiviral and anticancer effects. This paper comprehensively compiles all studies that have featured

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McGeoch, Duncan J. "The human herpesviruses." Trends in Microbiology 2, no. 1 (1994): 31–32. http://dx.doi.org/10.1016/0966-842x(94)90343-3.

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Dochnal, Sara A., Alison K. Francois, and Anna R. Cliffe. "De Novo Polycomb Recruitment: Lessons from Latent Herpesviruses." Viruses 13, no. 8 (2021): 1470. http://dx.doi.org/10.3390/v13081470.

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The Human Herpesviruses persist in the form of a latent infection in specialized cell types. During latency, the herpesvirus genomes associate with cellular histone proteins and the viral lytic genes assemble into transcriptionally repressive heterochromatin. Although there is divergence in the nature of heterochromatin on latent herpesvirus genomes, in general, the genomes assemble into forms of heterochromatin that can convert to euchromatin to permit gene expression and therefore reactivation. This reversible form of heterochromatin is known as facultative heterochromatin and is most common

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Maple, Peter A. C. "COVID-19, SARS-CoV-2 Vaccination, and Human Herpesviruses Infections." Vaccines 11, no. 2 (2023): 232. http://dx.doi.org/10.3390/vaccines11020232.

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There are several human herpesviruses. A common characteristic of infection by these viruses is latency, by which the virus assumes a non-replicative state, subverting the attentions of the host’s immune response. In immunocompetent hosts, herpesviruses are immunologically controlled, although periodic virus shedding can occur. In situations where immunological control is lost, herpesviruses can reactivate and produce clinically apparent disease. It is now becoming apparent that COVID-19 or exposure to COVID-19 vaccines can exert several effects on the immune system. The pandemic of COVID-19 s

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Johnson, Grant, Susan Nelson, Martin Petric, and Raymond Tellier. "Comprehensive PCR-Based Assay for Detection and Species Identification of Human Herpesviruses." Journal of Clinical Microbiology 38, no. 9 (2000): 3274–79. http://dx.doi.org/10.1128/jcm.38.9.3274-3279.2000.

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The description and evaluation of a PCR-based assay for the detection and species identification of the eight known human herpesviruses are presented. Two primer pairs targeting well-conserved regions of the genome allowed the amplification of the DNAs of all known human herpesviruses at a high level of sensitivity (10 to 100 genome copies for most viruses). Identification of the virus species was achieved through restriction enzyme digestion withBamHI and BstUI, which yielded fragment sizes that were characteristic for each herpesvirus. Furthermore, it was demonstrated that this restriction e

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Kaufer, Benedikt B., Keith W. Jarosinski, and Nikolaus Osterrieder. "Herpesvirus telomeric repeats facilitate genomic integration into host telomeres and mobilization of viral DNA during reactivation." Journal of Experimental Medicine 208, no. 3 (2011): 605–15. http://dx.doi.org/10.1084/jem.20101402.

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Some herpesviruses, particularly lymphotropic viruses such as Marek’s disease virus (MDV) and human herpesvirus 6 (HHV-6), integrate their DNA into host chromosomes. MDV and HHV-6, among other herpesviruses, harbor telomeric repeats (TMRs) identical to host telomeres at either end of their linear genomes. Using MDV as a natural virus-host model, we show that herpesvirus TMRs facilitate viral genome integration into host telomeres and that integration is important for establishment of latency and lymphoma formation. Integration into host telomeres also aids in reactivation from the quiescent st

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Vikulov, G. Kh, and I. V. Oradovskaya. "Clinical and immunological characteristics of COVID-19 associated with human herpesvirus infections: management algorithms for mixed infections." Infekcionnye bolezni 19, no. 4 (2021): 79–90. http://dx.doi.org/10.20953/1729-9225-2021-4-79-90.

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This article discusses important aspects of human herpesvirus reactivation associated with COVID-19 and secondary immunodeficiency. It also presents the overall diagnostic and treatment algorithm for patients with mixed infections. Key words: SARS-CoV-2, COVID-19, human herpesviruses, epidemiology, algorithm

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Tiwari, Vaibhav, and Deepak Shukla. "Nonprofessional Phagocytosis Can Facilitate Herpesvirus Entry into Ocular Cells." Clinical and Developmental Immunology 2012 (2012): 1–8. http://dx.doi.org/10.1155/2012/651691.

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Phagocytosis is a major mechanism by which the mediators of innate immunity thwart microbial infections. Here we demonstrate that human herpesviruses may have evolved a common mechanism to exploit a phagocytosis-like entrapment to gain entry into ocular cells. While herpes simplex virus-1 (HSV-1) causes corneal keratitis, cytomegalovirus (CMV) is associated with retinitis in immunocompromised individuals. A third herpesvirus, human herpesvirus-8 (HHV-8), is crucial for the pathogenesis of Kaposi’s sarcoma, a common AIDS-related tumor of eyelid and conjunctiva. Using laser scanning confocal mic

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Besednova, N. N., I. D. Makarenkova, T. N. Zvyagintseva, T. I. Imbs, L. M. Somova, and T. S. Zaporozhets. "Antiviral action and pathogenetic targets for seaweed sulfated polysaccharides in herpesvirus infections." Biomeditsinskaya Khimiya 62, no. 3 (2016): 217–27. http://dx.doi.org/10.18097/pbmc20166203217.

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The review summarizes results of studies of effects of sulfated polysaccharides from seaweed on herpesviruses and the course of herpesvirus infections. Importance of this problem is determined by the prevalence of herpesviruses that can persist in the human body and demonstrate a high degree of immune mimicry and resistance to antiviral agents. A wide range of physiological action of sulfated polysaccharides, receptor agonists of innate and adaptive immune cells, which possess potent antiviral, antioxidant and anti-inflammatory activities, open the possibility of their use for creation of new

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Morissette, Guillaume, and Louis Flamand. "Herpesviruses and Chromosomal Integration." Journal of Virology 84, no. 23 (2010): 12100–12109. http://dx.doi.org/10.1128/jvi.01169-10.

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ABSTRACT Herpesviruses are members of a diverse family of viruses that colonize all vertebrates from fish to mammals. Although more than one hundred herpesviruses exist, all are nearly identical architecturally, with a genome consisting of a linear double-stranded DNA molecule (100 to 225 kbp) protected by an icosahedral capsid made up of 162 hollow-centered capsomeres, a tegument surrounding the nucleocapsid, and a viral envelope derived from host membranes. Upon infection, the linear viral DNA is delivered to the nucleus, where it circularizes to form the viral episome. Depending on several

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Münz, Christian. "Natural Killer Cell Responses during Human γ-Herpesvirus Infections". Vaccines 9, № 6 (2021): 655. http://dx.doi.org/10.3390/vaccines9060655.

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Herpesviruses are main sculptors of natural killer (NK) cell repertoires. While the β-herpesvirus human cytomegalovirus (CMV) drives the accumulation of adaptive NKG2C-positive NK cells, the human γ-herpesvirus Epstein–Barr virus (EBV) expands early differentiated NKG2A-positive NK cells. While adaptive NK cells support adaptive immunity by antibody-dependent cellular cytotoxicity, NKG2A-positive NK cells seem to preferentially target lytic EBV replicating B cells. The importance of this restriction of EBV replication during γ-herpesvirus pathogenesis will be discussed. Furthermore, the modifi

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Sanchez, Veronica, and William Britt. "Human Cytomegalovirus Egress: Overcoming Barriers and Co-Opting Cellular Functions." Viruses 14, no. 1 (2021): 15. http://dx.doi.org/10.3390/v14010015.

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The assembly of human cytomegalovirus (HCMV) and other herpesviruses includes both nuclear and cytoplasmic phases. During the prolonged replication cycle of HCMV, the cell undergoes remarkable changes in cellular architecture that include marked increases in nuclear size and structure as well as the reorganization of membranes in cytoplasm. Similarly, significant changes occur in cellular metabolism, protein trafficking, and cellular homeostatic functions. These cellular modifications are considered integral in the efficient assembly of infectious progeny in productively infected cells. Nuclea

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Buchbinder, A., D. V. Ablashi, C. Saxinger, et al. "HUMAN HERPESVIRUS-6 AND CROSS-REACTIVITY WITH OTHER HERPESVIRUSES." Lancet 333, no. 8631 (1989): 217. http://dx.doi.org/10.1016/s0140-6736(89)91228-2.

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Morris, DavidJ, Edward Littler, Debbie Jordan, JohnR Arrand, Martin Andre, and Bertfried Matz. "ANTIBODY RESPONSES TO HUMAN HERPESVIRUS 6 AND OTHER HERPESVIRUSES." Lancet 332, no. 8625 (1988): 1425–26. http://dx.doi.org/10.1016/s0140-6736(88)90618-6.

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Muller, Clotilde, Sophie Alain, Thomas F. Baumert, Gaëtan Ligat, and Sébastien Hantz. "Structures and Divergent Mechanisms in Capsid Maturation and Stabilization Following Genome Packaging of Human Cytomegalovirus and Herpesviruses." Life 11, no. 2 (2021): 150. http://dx.doi.org/10.3390/life11020150.

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Herpesviruses are the causative agents of several diseases. Infections are generally mild or asymptomatic in immunocompetent individuals. In contrast, herpesvirus infections continue to contribute to significant morbidity and mortality in immunocompromised patients. Few drugs are available for the treatment of human herpesvirus infections, mainly targeting the viral DNA polymerase. Moreover, no successful therapeutic options are available for the Epstein–Barr virus or human herpesvirus 8. Most licensed drugs share the same mechanism of action of targeting the viral polymerase and thus blocking

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Greensill, Julie, Julie A. Sheldon, Neil M. Renwick, et al. "Two Distinct Gamma-2 Herpesviruses in African Green Monkeys: a Second Gamma-2 Herpesvirus Lineage among Old World Primates?" Journal of Virology 74, no. 3 (2000): 1572–77. http://dx.doi.org/10.1128/jvi.74.3.1572-1577.2000.

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ABSTRACT Primate gamma-2 herpesviruses (rhadinoviruses) have so far been found in humans (Kaposi's sarcoma-associated herpesvirus [KSHV], also called human herpesvirus 8), macaques (Macaca spp.) (rhesus rhadinovirus [RRV] and retroperitoneal fibromatosis herpesvirus [RFHV]), squirrel monkeys (Saimiri sciureus) (herpesvirus saimiri), and spider monkeys (Ateles spp.) (herpesvirus ateles). Using serological screening and degenerate consensus primer PCR for the viral DNA polymerase gene, we have detected sequences from two distinct gamma-2 herpesviruses, termedChlorocebus rhadinovirus 1 (ChRV1) an

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Umbach, Jennifer L., Maria A. Nagel, Randall J. Cohrs, Donald H. Gilden, and Bryan R. Cullen. "Analysis of Human Alphaherpesvirus MicroRNA Expression in Latently Infected Human Trigeminal Ganglia." Journal of Virology 83, no. 20 (2009): 10677–83. http://dx.doi.org/10.1128/jvi.01185-09.

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ABSTRACT Analysis of cells infected by a wide range of herpesviruses has identified numerous virally encoded microRNAs (miRNAs), and several reports suggest that these viral miRNAs are likely to play key roles in several aspects of the herpesvirus life cycle. Here we report the first analysis of human ganglia for the presence of virally encoded miRNAs. Deep sequencing of human trigeminal ganglia latently infected with two pathogenic alphaherpesviruses, herpes simplex virus 1 (HSV-1) and varicella-zoster virus (VZV), confirmed the expression of five HSV-1 miRNAs, miR-H2 through miR-H6, which ha

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Ehlers, Bernhard, Judit Küchler, Nezlisah Yasmum, et al. "Identification of Novel Rodent Herpesviruses, Including the First Gammaherpesvirus of Mus musculus." Journal of Virology 81, no. 15 (2007): 8091–100. http://dx.doi.org/10.1128/jvi.00255-07.

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ABSTRACT Rodent herpesviruses such as murine cytomegalovirus (host, Mus musculus), rat cytomegalovirus (host, Rattus norvegicus), and murine gammaherpesvirus 68 (hosts, Apodemus species) are important tools for the experimental study of human herpesvirus diseases. However, alphaherpesviruses, roseoloviruses, and lymphocryptoviruses, as well as rhadinoviruses, that naturally infect Mus musculus (house mouse) and other Old World mice are unknown. To identify hitherto-unknown rodent-associated herpesviruses, we captured M. musculus, R. norvegicus, and 14 other rodent species in several locations

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Mercader, Maria, Brian J. Nickoloff, and Kimberly E. Foreman. "Induction of Human Immunodeficiency Virus 1 Replication by Human Herpesvirus 8." Archives of Pathology & Laboratory Medicine 125, no. 6 (2001): 785–89. http://dx.doi.org/10.5858/2001-125-0785-iohivr.

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Abstract Background.—Human immunodeficiency virus 1 (HIV-1)–infected individuals are commonly infected with herpesviruses, including cytomegalovirus, herpes simplex virus, varicella-zoster virus, and human herpesvirus 8 (HHV-8, also known as Kaposi sarcoma–associated herpesvirus [KSHV]). Previous studies have demonstrated that coinfection with herpesviruses can modulate HIV-1 replication. This can occur either through direct interaction between the 2 viruses or through secondary effects resulting from the release of cellular factors in response to infection. Objective.—To investigate HIV-1 rep

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Caragliano, Enrico, Wolfram Brune, and Jens B. Bosse. "Herpesvirus Replication Compartments: Dynamic Biomolecular Condensates?" Viruses 14, no. 5 (2022): 960. http://dx.doi.org/10.3390/v14050960.

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Recent progress has provided clear evidence that many RNA-viruses form cytoplasmic biomolecular condensates mediated by liquid–liquid phase separation to facilitate their replication. In contrast, seemingly contradictory data exist for herpesviruses, which replicate their DNA genomes in nuclear membrane-less replication compartments (RCs). Here, we review the current literature and comment on nuclear condensate formation by herpesviruses, specifically with regard to RC formation. Based on data obtained with human cytomegalovirus (human herpesvirus 5), we propose that liquid and homogenous earl

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Blaškovičová, Jana, and Ján Labuda. "Analytical methods in herpesvirus genomics." Acta Chimica Slovaca 7, no. 2 (2014): 109–18. http://dx.doi.org/10.2478/acs-2014-0019.

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Abstract Genomics is a branch of bioanalytical chemistry characterized as the study of the genome structure and function. Genome represents the complete set of chromosomal and extrachromosomal genes of an organism, a cell, an organelle or a virus. There are at least five from eight species of herpesviruses commonly widespread among humans, Herpes simplex virus type 1 and 2, Varicella zoster virus, Epstein-Barr virus and Cytomegalovirus. Human gammaherpesviruses can cause serious diseases including B-cell lymphoma and Kaposi’s sarcoma. Diagnostics and study of the herpesviruses is directly depe

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Kang, Jin Han. "New Human Herpesviruses Infections." Journal of the Korean Medical Association 41, no. 3 (1998): 290. http://dx.doi.org/10.5124/jkma.1998.41.3.290.

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TAJIMA, Masako, Fumiko TAKEDA, Toshio TAKESHIMA, Tokuyuki YOKOHATA, and Kouta OKINAGA. "Human Herpesviruses Infections (I)." Journal of the Japanese Association for Infectious Diseases 65, no. 7 (1991): 799–807. http://dx.doi.org/10.11150/kansenshogakuzasshi1970.65.799.

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Kramata, Pavel, and Ivan Votruba. "Enzymes of Human Herpesviruses." Collection of Czechoslovak Chemical Communications 57, no. 8 (1992): 1577–612. http://dx.doi.org/10.1135/cccc19921577.

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The properties of human herpesvirus-encoded enzymes are reviewed and the importance of sequence analysis of viral genomes as well as the experiments on characteristics of enzymes isolated from infected cell cultures are emphasized. The following enzymes are described in detail: DNA replication complex consisting of DNA polymerase, DNA helicase-primase, single-stranded DNA binding protein and origin binding protein, further thymidine kinase, ribonucleotide reductase, deoxyuridine triphosphatase as well as uracil-DNA-glycosylase, deoxyribonuclease and protein kinase. The importance of these enzy

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Pilet, Ch. "Human and animal herpesviruses." Comparative Immunology, Microbiology and Infectious Diseases 14, no. 2 (1991): V. http://dx.doi.org/10.1016/0147-9571(91)90121-s.

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