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Dissertations / Theses on the topic 'Human induce pluripotent stem cell'

Author: Grafiati

Published: 14 March 2023

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1

Matz, Peggy. "Human induced pluripotent stem cell–based modeling of hepatogenesis." Doctoral thesis, Humboldt-Universität zu Berlin, Lebenswissenschaftliche Fakultät, 2016. http://dx.doi.org/10.18452/17530.

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In dieser Studie wurden nicht-integrative Vektorkonstrukte zur Reprogrammierung von zwei menschlichen Zelllinien (HFF1, HUVEC) verwendet, um integrations-freie, episomal generierte iPSC Zelllinien (E-iPSCs) zu generieren. Darüber hinaus wurden diese iPSCs zu sogenannten Leberzell-ähnlichen Zellen (HLCs) differenziert. Hierzu konnten die verschiedenen Stufen der Hepatogenese und die potentielle Reifung zu Leberzellen untersucht sowie mit fötalen und ausgereiften menschlichen Leberzellen verglichen werden. Diese Studie konnte Gen-regulierende Netzwerke aufdecken, welche eine pi-potentiale Vorlä

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2

Chen, Xike. "Integration Capacity of Human Induced Pluripotent Stem Cell-Derived Cartilage." Kyoto University, 2019. http://hdl.handle.net/2433/242390.

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3

Zhang, Jiao, and 张姣. "Regulation of cell proliferation and modulation of differentiation in human induced pluripotent stem cell-derived mesenchumal stem cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B49617503.

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Functional mesenchymal stem cells (MSCs) derived from human induced pluripotent stem cells (iPSCs) may represent an unlimited cell source with superior therapeutic benefits for tissue regeneration to somatic tissue, such as bone marrow (BM)-derived MSC. In the first part of this project, I investigated whether the differential expression of ion channels in iPSC-MSCs was responsible for their higher proliferation capacity than that of BM-MSCs. The expression of ion channels for K+, Na+, Ca2+ and Cl- currents was assessed by reverse transcription-polymerase chain reaction (RT-PCR). The function

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4

Ratanasirintrawoot, Sutheera. "Defining markers and mechanisms of human somatic cell reprogramming." Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:11236.

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Somatic cells can be reprogrammed into induced pluripotent stem (iPS) cells by over expression of the transcription factors OCT4, SOX2, KLF4 and c-MYC. Using serial live cell immunofluorescence imaging of human fibroblasts undergoing reprogramming, we traced the emergence of nascent iPS cell colonies among heterogeneous cell populations and defined the kinetics of marker expression. We identified distinct colony types that morphologically resemble embryonic stem (ES) cells yet differ in molecular phenotype and differentiation potential. By analyzing expression of pluripotency markers, methylat

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5

Zorzan, Irene. "Dissecting the role of TGF-beta pathway in human Pluripotent Stem Cells." Doctoral thesis, Università degli studi di Padova, 2019. http://hdl.handle.net/11577/3424722.

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Human Embryonic Stem Cells (hESCs) and induced Pluripotent Stem cells (hiPSCs) are characterized by the ability to give rise all cell types found in the adult and to be expanded indefinitely in vitro. Understanding the molecular mechanisms controlling pluripotency is fundamental to differentiate human pluripotent cells into cells types useful for clinical applications. The signaling pathway of TGF-beta and FGF are known to maintain pluripotency in human cells. Only a handful of factors controlling pluripotency have previously been identified, such as the transcription factors OCT4, SOX2 and NA

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6

Yamashiro, Chika. "Generation of human oogonia from induced pluripotent stem cells in vitro." Kyoto University, 2019. http://hdl.handle.net/2433/242826.

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7

Rohani, Leili, Claire Fabian, Heidrun Holland, et al. "Generation of human induced pluripotent stem cells using non-synthetic mRNA." Universitätsbibliothek Leipzig, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-205889.

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Here we describe some of the crucial steps to generate induced pluripotent stemcells (iPSCs) usingmRNA transfection. Our approach uses a V. virus-derived capping enzyme instead of a cap-analog, ensuring 100% proper cap orientation for in vitro transcribedmRNA. V. virus\' 2′-O-Methyltransferase enzymecreates a cap1 structure found in higher eukaryotes and has higher translation efficiency compared to other methods. Use of the polymeric transfection reagent polyethylenimine proved superior to other transfection methods. The mRNA created via this method did not trigger an intracellular immune res

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8

Lau, Kei-ling Kelly, and 劉己綾. "Human pluripotent stem cells as a source of dendritic cells to induce immune tolerance." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/197516.

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Dendritic Cells (DCs) are professional antigen presenting cells that play a crucial role in the induction of immune tolerance. Although DCs have been a potential target for immunotherapy, the amount of DCs in blood source is limited and ex vivo expansion has been inefficient. Human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) provide a great source in cell-based therapy because of their self-renewal ability and pluripotency. My project focuses on generating tolerogenic DCs (tDCs) from human pluripotent stem cells (i.e. hESCs and iPSCs) and their characterization.

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9

Jambi, Majed. "Differentiation of Human Atrial Myocytes from Endothelial Progenitor Cell-Derived Induced Pluripotent Stem Cells." Thèse, Université d'Ottawa / University of Ottawa, 2014. http://hdl.handle.net/10393/31158.

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Recent advances in cellular reprogramming have enabled the generation of embryoniclike cells from virtually any cell of the body. These inducible pluripotent stem cells (iPSCs) are capable of indefinite self-renewal while maintaining the ability to differentiate into all cell types. Nowhere will this technology have a greater impact than in the ability to generate disease and patient-specific cell lines. Here we explore the capacity of human iPSCs reprogrammed from peripheral blood endothelial progenitor cells lines to differentiate into atrial myocytes for the study of patient specific atrial

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10

Ruiz-Torres, Sonya Jomara. "Modeling Fanconi Anemia in Squamous Epithelium using Human Induced Pluripotent Stem Cell-Derived Organoids." University of Cincinnati / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1573573103136768.

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11

Awaya, Tomonari. "Selective Development of Myogenic Mesenchymal Cells from Human Embryonic and Induced Pluripotent Stem Cells." Kyoto University, 2013. http://hdl.handle.net/2433/180602.

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12

Li, Quan. "Synthetic Hydrogel-Based 3D Culture System for Maintenance of Human Induced Pluripotent Stem Cell." Thesis, Kansas State University, 2017. http://hdl.handle.net/2097/36189.

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Master of Science<br>Department of Grain Science and Industry<br>X. Susan Sun<br>Human induced pluripotent stem cells (hiPSCs) are generated from human somatic cells using defined transcription factors. These cells possess characteristics very similar to that of human embryonic stem cells including the ability to differentiate into cell types of all three germ layers. HiPSCs show great potential in clinical researches like drug screening and regenerative medicine, that all require large amount of cells cultured under well-defined conditions. The most common culture methods used for hiPSCs are

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13

Nakane, Takeichiro. "Impact of Cell Composition and Geometry on Human Induced Pluripotent Stem Cells-Derived Engineered Cardiac Tissue." Kyoto University, 2018. http://hdl.handle.net/2433/232090.

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14

Kamakura, Tsukasa. "Ultrastructural Maturation of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes in a Long-Term Culture." Kyoto University, 2015. http://hdl.handle.net/2433/199202.

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15

Nakamura, Sou. "Expandable Megakaryocyte Cell Lines Enable Clinically Applicable Generation of Platelets from Human Induced Pluripotent Stem Cells." Kyoto University, 2015. http://hdl.handle.net/2433/202779.

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16

Kimura, Azuma. "Small molecule AT7867 proliferates PDX1-expressing pancreatic progenitor cells derived from human pluripotent stem cells." Kyoto University, 2019. http://hdl.handle.net/2433/242422.

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17

Palandri, Chiara. "DIFFERENT METHODS TO MODEL CARDIAC ARRHYTHMOGENIC DISEASES: FROM TRANSFECTED CELLS TO CARDIOMYOCYTES DERIVED FROM HUMAN INDUCED PLURIPOTENT STEM CELLS." Doctoral thesis, Università di Siena, 2021. http://hdl.handle.net/11365/1143558.

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Cardiomyopathies are a heterogeneous group of diseases of the heart muscle, associated to alterations of cardiac currents and ions handling that cause the impairment of the cardiac function leading to the insurgence of arrhythmias, heart failure and sudden death. In this project, we focus our attention on ion channel diseases. I will use different models, from expression system, to human adult cardiomyocytes isolated from septal samples, until human induced pluripotent stem cells derived cardiomyocytes (hiPSC-CM) to design cardiomyopathies and used it to test the efficacy and safeness of “old”

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18

Cleary, Elaine Marie. "Effect of C9orf72 hexanucleotide repeat expansions on human induced pluripotent stem cell derived oligodendrocytes." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/28816.

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A hexanucleotide repeat expansion in the C9orf72 gene is the most common cause of familial amyotrophic lateral sclerosis and frontotemporal dementia. Genetic testing for this pathogenic mutation is challenging due to its GC rich, repetitive nature. I developed PCR based assays to detect the presence of the pathogenic variant, which were used in screening an archival cohort of Scottish ALS patients, and have also been implemented within a diagnostic setting. These PCR assays allow amplification of larger repeat expansions than have previously been reported, and can determine whether a C9orf72 e

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19

Martewicz, Sebastian. "Human pluripotent stem cell-based microtechnologies for in vitro modeling of cardiac diseases." Doctoral thesis, Università degli studi di Padova, 2015. http://hdl.handle.net/11577/3424118.

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Human pluripotent stem cells are quickly emerging as a fundamental tool for in vitro studies. In particular, the advent of “induced pluripotency” opened completely new horizons for in vitro disease modeling and patient-specific disease-on-a-dish therapeutic approach screening. The easy access to cell types of human origin hardly available otherwise, with virtually infinite amounts in a donor-unrestricted manner, unlocked in vitro studies for human tissues such as brain, pancreas and the heart. In the latter case, the need for new models of human cardiac physiology and physiopathology is highli

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20

Kitahata, Shohei. "Critical Functionality Effects from Storage Temperature on Human Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium Cell Suspensions." Kyoto University, 2019. http://hdl.handle.net/2433/242417.

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21

Nakajima, Taiki. "Modeling human somite development and fibrodysplasia ossificans progressiva with induced pluripotent stem cells." Kyoto University, 2019. http://hdl.handle.net/2433/242429.

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22

Achberger, Kevin [Verfasser]. "Human retinal organoids - Exploration of a human induced pluripotent stem cell-derived in vitro model / Kevin Achberger." Tübingen : Universitätsbibliothek Tübingen, 2021. http://d-nb.info/1231790687/34.

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23

Maus, Andreas [Verfasser]. "Human induced pluripotent stem cell models used in the study of doxorubicin-induced cardiomyopathy / Andreas Maus." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2020. http://d-nb.info/1228364427/34.

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24

Ikuno, Takeshi. "Efficient and robust differentiation of endothelial cells from human induced pluripotent stem cells via lineage control with VEGF and cyclic AMP." Kyoto University, 2017. http://hdl.handle.net/2433/227586.

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25

Zhao, Chen. "Investigation of the cell- and non-cell autonomous impact of the C9orf72 mutation on human induced pluripotent stem cell-derived astrocytes." Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/25903.

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Amyotrophic lateral sclerosis (ALS) is a late onset neurodegenerative disorder characterised by selective loss of upper and lower motor neurons (MNs). Recently, the GGGGCC (G4C2) hexanucleotide repeat expansion in chromosome 9 open reading frame 72 (C9orf72) has been identified as the most common genetic cause of ALS, highlighting the importance of studying the pathogenic mechanisms underlying this mutation. Accumulating evidence implicates that ALS is a multisystem and multifactor disease. Specifically, non-neuronal cells, astrocytes in particular, are also affected by toxicity mediated by AL

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26

Feldman, Danielle A. (Danielle Anagela). "Human induced pluripotent stem cell models of Rett Syndrome reveal deficits in early cortical development." Thesis, Massachusetts Institute of Technology, 2016. http://hdl.handle.net/1721.1/107869.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Brain and Cognitive Sciences, 2016.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>Rett Syndrome (RTT) is a pervasive, X-linked neurodevelopmental disorder that predominantly affects girls. The clinical patient features of RTT are most commonly reported to emerge between the ages of 6-18 months and as such, RTT has largely been considered to be a postnatal disorder. The vast majority of cases are caused by sporadic mutations in the gene encoding methyl CpG-binding protein 2 (MeCP2), which

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27

Nishizawa, Masatoshi. "Epigenetic variation between human induced pluripotent stem cell lines is an indicator of differentiation capacity." Kyoto University, 2017. http://hdl.handle.net/2433/218003.

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28

Rashid, Sheikh Tamir. "Human induced pluripotent stem cells for in vitro modeling and cell based therapy of α-1 antitrypsin deficiency". Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610175.

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29

Requena, Osete Jordi. "Advancing induced pluripotent stem cell (iPSC) technology by assessing genetic instability and immune response." Doctoral thesis, Universitat de Barcelona, 2017. http://hdl.handle.net/10803/457970.

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Induced pluripotent stem cells (iPSC) can be made from adult somatic cells by reprogramming them with Oct4, Sox2, Klf4 and c-Myc. IPSC have given rise to a new technology to study and treat human disease (Takahashi et al., 2007). However, before iPSC clinical application, we need to step back and address two main challenges: (i) Genetic stability of iPSC. (ii) Immune response of iPSC-derived cells. To address these key issues, the overall mission of this PhD thesis is to advance iPSC technology by addressing two objectives. First, is to replace c-Myc with Cyclin D1 in the reprogramming co

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30

O'Brien, Susanne. "Induced human pluripotent stem cell-derived NK cells as an alternative source of lymphocytes for anti-cancer immunotherapy." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10041819/.

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Human induced pluripotent stem cells (hiPSCs) hold great promise in regenerative medicine as they have the potential to differentiate into any specialized cell type and retain unlimited self-renewal capacity in vitro. The use of hiPSC-derived lymphocytes for adoptive cell transfer therapies is appealing as it provides a potentially indefinite cell source and a platform for genetically modifying cells. Natural killer (NK) cell-based therapy has shown promising results in the treatment of haematological malignancies and the unlimited derivation of NK cells from hiPSCs could overcome the current

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31

Fujiwara, Masataka. "Induction and enhancement of cardiac cell differentiation from mouse and human induced pluripotent stem cells with cyclosporin-A." Kyoto University, 2011. http://hdl.handle.net/2433/142089.

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32

Yulius, Hermanto. "Transplantation of feeder-free human induced pluripotent stem cell-derived cortical neuron progenitors in adult male Wistar rats with focal brain ischemia." Kyoto University, 2019. http://hdl.handle.net/2433/242389.

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33

Sasaki, Ben. "Transient FOXO1 inhibition in pancreatic endoderm promotes the generation of NGN3+ endocrine precursors from human iPSCs." Kyoto University, 2020. http://hdl.handle.net/2433/259709.

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34

Kalra, Spandan Kaur. "Towards the development of human induced pluripotent stem cell models for Duchenne muscular dystrophy-associated cardiomyopathy." Thesis, University of Nottingham, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.715123.

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Duchenne Muscular Dystrophy (DMD) is a fatal X-linked condition that affects 1 in 4710 boys. Causative mutations in the DMD gene result in a loss of functional expression of the dystrophin protein. Patients usually die in their second or third decade due to cardiac or respiratory failure. Incidence of cardiomyopathy increases with age, such that clinical symptoms are observed in 25% of boys below 6 years of age, but by the teenage years prevalence is 100%. The current treatments are palliative and there are no cures. Numerous cell-based and animal models for DMD exist, but each has its limitat

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35

Maifoshie, Evie. "Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) for studying the role of MAP4K4 kinase in cell death." Thesis, Imperial College London, 2014. http://hdl.handle.net/10044/1/44977.

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Kinases comprise universal signalling cascades potentially pivotal to cardiac cell death pathways. Cell death is divided into several modes, chiefly apoptosis and necrosis. Both contribute to the pathophysiology of heart disease, with overlapping signalling pathways of caspase activation and apoptogen release from the mitochondria. This project focuses on the genetic validation of the stress-activated protein kinase, MAP4K4 / HGK, which functions as a control point integrating diverse signals for cardiomyocyte cell death. MAP4K4 and its reported target MAP3K7 / TAK1 appear to operate upstream

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36

Chang, Chia-Wei. "Polycistronic lentiviral vector for hit and run reprogramming of mouse and human somatic cells to induced pluripotent stem cell." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2009. https://www.mhsl.uab.edu/dt/2009p/changc.pdf.

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37

Shoji, Emi. "Early pathogenesis of Duchenne muscular dystrophy modelled in patient-derived human induced pluripotent stem cells." Kyoto University, 2015. http://hdl.handle.net/2433/200495.

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38

Suzuki, Naoya. "Pluripotent cell models of Fanconi anemia identify the early pathological defect in human hemoangiogenic progenitors." Kyoto University, 2015. http://hdl.handle.net/2433/199215.

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39

Crutchley, James E. B. "Automation and scale-up of human induced pluripotent stem cell models of cardiovascular disease for drug screening." Thesis, University of Nottingham, 2016. http://eprints.nottingham.ac.uk/32207/.

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The global cost of heart failure is USD$45 billion and set to double in the next 15 years. The only method of treatment is heart transplant but demand far exceeds supply and is projected to increase. Meanwhile, global pharmaceutical development has been hindered by poor drug development success rates. Of the drugs that make it to phase I clinical trials, only 8 % pass phase III and existing drug screens do not always accurately predict or detect adverse cardiac events. Cardiotoxicity is the underlying reason for 26 % of safety related drug withdrawals between 1990-2006. Therefore, a source of

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40

Matsubara, Masaki. "Analysis of mitochondrial function in human induced pluripotent stem cells from patients with mitochondrial diabetes due to the A3243G mutation." Kyoto University, 2018. http://hdl.handle.net/2433/232452.

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41

Tangruksa, Benyapa. "Cardiac hypertrophy in human stem cells-derived cardiomyocytes : Biomarker identification and pathway analysis of endotheline-1 induced cardiac hypertrophy in human induced pluripotent stem cells-derived cardiomyocytes." Thesis, Högskolan i Skövde, Institutionen för biovetenskap, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-18902.

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Cardiac hypertrophy is when heart muscles thicken as an adaptive response to several stimuli. Prolonged pathological cardiac hypertrophy can lead to heart failure and severe cardiovascular diseases. Scientists have faced challenges in studying cardiac hypertrophy due to the lack of human cardiomyocytes available. Recently, hypertrophic model using human induced pluripotent stem cell-derived cardiomyocytes was introduced. In this study, expression profiles of in vitroendothelin-1 induced cardiac hypertrophy model were investigated at different time points. The study aimed to examine molecular p

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42

Moad, Mohammad. "Influence of cell type of origin to the differentiation potential of induced pluripotent stem cells derived from human urinary tract cells." Thesis, University of Newcastle upon Tyne, 2015. http://hdl.handle.net/10443/2803.

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Background: Direct reprogramming of human somatic cells to pluripotent embryonic stem (ES) cell -like cells, termed induced pluripotent stem (iPS) cells, can be achieved by expression of defined transcription factors. The potential use of iPS cells derived from the urinary tract provides a substantial opportunity in developing new disease models, drug screening and tissue engineering. We aimed to generate, for the first time, human induced pluripotent stem cells derived from the urinary tract (UT-iPS) cells and to assess capacity for directed differentiation into bladder lineages. Methods: Hum

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43

Yoshinaga, Daisuke. "Phenotype-Based High-Throughput Classification of Long QT Syndrome Subtypes Using Human Induced Pluripotent Stem Cells." Kyoto University, 2020. http://hdl.handle.net/2433/253171.

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44

Hirose, Sayako. "Propranolol Attenuates Late Sodium Current in a Long QT Syndrome Type 3-Human Induced Pluripotent Stem Cell Model." Doctoral thesis, Kyoto University, 2021. http://hdl.handle.net/2433/265195.

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45

Korogi, Yohei. "In Vitro Disease Modeling of Hermansky-Pudlak Syndrome Type 2 Using Human Induced Pluripotent Stem Cell-Derived Alveolar Organoids." Kyoto University, 2019. http://hdl.handle.net/2433/243303.

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46

Miyawaki, Yoshifumi. "Zonisamide promotes survival of human induced pluripotent stem cell-derived dopaminergic neurons in the striatum of female rats." Kyoto University, 2020. http://hdl.handle.net/2433/259730.

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47

Maurissen, Thomas Luc. "Synergistic gene editing in human iPS cells via cell cycle and DNA repair modulation." Kyoto University, 2020. http://hdl.handle.net/2433/254520.

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48

GIANI, ALICE MARIA. "GENERATION OF AUTHENTIC HUMAN NEOCORTICAL NEURONS FROM INDUCED PLURIPOTENT STEM CELLS TO INVESTIGATE 7Q11.23 GENE DOSAGE IMBALANCES." Doctoral thesis, Università degli Studi di Milano, 2018. http://hdl.handle.net/2434/561835.

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Questo lavoro di tesi ha avuto lo scopo di studiare lo sviluppo della neocorteccia umana ed i meccanisimi alla base della sua compromissione che risultano nell’insorgenza di patologie del neurosviluppo mediante un’analisi dei profili trascrizionali e della morfologia di neuroni neocorticali umani generati a partire da cellule staminali pluripotenti indotte (iPSCs). Data l’importanza di basarsi su un paradigma di neurogenesi in vitro riproducibile e affidabile nel generare neuroni neocoritcali umani autentici, prima di adottare questo sistema modello per lo studio di patologie del neurosvilup

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49

BOTTI, SOFIA. "Mathematical modeling of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes (hiPSC-CMs): from ionic currents to 3D ventricle models." Doctoral thesis, Università degli studi di Pavia, 2022. https://hdl.handle.net/11571/1467309.

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50

Okuyama, Hideaki. "Transplantation of multiciliated airway cells derived from human iPS cells using an artificial tracheal patch into rat trachea." Kyoto University, 2020. http://hdl.handle.net/2433/253142.

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