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Dissertations / Theses on the topic 'Human Induced neurons'

Author: Grafiati

Published: 15 June 2024

Last updated: 31 July 2025

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1

Melo, de Farias Ana Raquel. "Probing the Alzheimer’s disease risk gene PTK2B using human-derived induced neurons." Electronic Thesis or Diss., Université de Lille (2022-....), 2023. http://www.theses.fr/2023ULILS062.

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La maladie d'Alzheimer (MA) est le principal type de démence et représente un défi majeur pour la santé publique mondiale. Elle se caractérise par un déclin progressif de la cognition, de la mémoire et des fonctions comportementales et touche plus de 55 millions de personnes dans le monde. Au niveau moléculaire, la MA se définit par la présence d'enchevêtrements neurofibrillaires agrégés dans les neurones et par l'accumulation de plaques d'amyloïde-β (Aβ) dans le cerveau. Ces caractéristiques pathologiques sont associées à des altérations de l'activité neuronale, à la perte de synapses, à la g

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Sánchez, Danés Adriana 1984. "Generation of human dopaminergic neurons from induced pluripotent stem cells to model Parkinson's disease." Doctoral thesis, Universitat Pompeu Fabra, 2012. http://hdl.handle.net/10803/96912.

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Parkinson’s disease (PD) is an incurable, chronically progressive neurodegenerative disease leading to premature invalidity and death. The locomotor disability of PD patients is mainly rooted in the gradual and insidious degeneration of dopaminergic neurons (DA) projecting from the midbrain substantia nigra (SN) to the basal ganglia striatum, a pathological process highlighted microscopically by the formation of insoluble cytosolic protein aggregates, known as Lewy bodies and Lewy neurites. The pathogenic mechanisms leading to PD remain poorly understood, arguably owing to the lack of suitable

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3

GIANI, ALICE MARIA. "GENERATION OF AUTHENTIC HUMAN NEOCORTICAL NEURONS FROM INDUCED PLURIPOTENT STEM CELLS TO INVESTIGATE 7Q11.23 GENE DOSAGE IMBALANCES." Doctoral thesis, Università degli Studi di Milano, 2018. http://hdl.handle.net/2434/561835.

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Questo lavoro di tesi ha avuto lo scopo di studiare lo sviluppo della neocorteccia umana ed i meccanisimi alla base della sua compromissione che risultano nell’insorgenza di patologie del neurosviluppo mediante un’analisi dei profili trascrizionali e della morfologia di neuroni neocorticali umani generati a partire da cellule staminali pluripotenti indotte (iPSCs). Data l’importanza di basarsi su un paradigma di neurogenesi in vitro riproducibile e affidabile nel generare neuroni neocoritcali umani autentici, prima di adottare questo sistema modello per lo studio di patologie del neurosvilup

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4

Fenske, Pascal [Verfasser]. "Characterization of synaptic transmission in autaptic cultured neurons derived from human induced pluripotent stem cells / Pascal Fenske." Berlin : Freie Universität Berlin, 2021. http://d-nb.info/1234451611/34.

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5

Toli, Diana Eleni. "Directed differentiation and purification of motor neurons from human induced pluripotent stem cells to model Amyotrophic Lateral Sclerosis." Thesis, Paris 5, 2013. http://www.theses.fr/2013PA05T044/document.

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La sclérose latérale amyotrophique (SLA) est une maladie neurodégénérative incurable de l’adulte qui affecte principalement les motoneurones. Les mécanismes conduisant à la mort des motoneurones restent mal connus, notamment du fait de l'hétérogénéité de la maladie et du manque d'accès aux neurones humains affectés. La technologie des cellules souches pluripotentes induites humaines (iPSc) est un outil prometteur pour la modélisation de la SLA, car elle offre la possibilité unique d'obtenir et d’étudier des motoneurones humains.Des clones d’iPSc de deux sujets témoins ont été générés et nous a

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Hermann, Andreas, Jeong Beom Kim, Sumitra Srimasorn, et al. "Factor-Reduced Human Induced Pluripotent Stem Cells Efficiently Differentiate into Neurons Independent of the Number of Reprogramming Factors." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-203366.

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Reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) by overexpression of the transcription factors OCT4, SOX2, KLF4, and c-Myc holds great promise for the development of personalized cell replacement therapies. In an attempt to minimize the risk of chromosomal disruption and to simplify reprogramming, several studies demonstrated that a reduced set of reprogramming factors is sufficient to generate iPSC. We recently showed that a reduction of reprogramming factors in murine cells not only reduces reprogramming efficiency but also may worsen subsequent differentiation. To

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7

Miyawaki, Yoshifumi. "Zonisamide promotes survival of human induced pluripotent stem cell-derived dopaminergic neurons in the striatum of female rats." Kyoto University, 2020. http://hdl.handle.net/2433/259730.

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8

Beevers, Joel Edward. "Investigating the function of microtubule-associated protein tau (MAPT) and its genetic association with Parkinson's using human iPSC-derived dopamine neurons." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:7a94919a-73a1-4a9f-b04d-cdf5b9c64be7.

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Parkinson's disease (PD) primarily manifests as loss of motor control through the degeneration of nigrostriatal dopaminergic neurons. The microtubule-associated protein tau (MAPT) locus is highly genetically associated with PD, wherein the H1 haplotype confers disease risk and the H2 haplotype is protective. As this haplotype variation does not alter the amino acid sequence, disease risk may be conferred by altered gene expression, either of total MAPT or of specific isoforms, of which there are six in adult human brain. To investigate haplotype-specific control of MAPT expression in the neuro

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9

Burton, Mark P., Declan J. McKeefry, Brendan T. Barrett, Chara Vakrou, and A. B. Morland. "Disruptions to human speed perception induced by motion adaptation and transcranial magnetic stimulation." Wiley, 2009. http://hdl.handle.net/10454/4731.

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no<br>To investigate the underlying nature of the effects of transcranial magnetic stimulation (TMS) on speed perception, we applied repetitive TMS (rTMS) to human V5/MT+ following adaptation to either fast- (20 deg/s) or slow (4 deg/s)-moving grating stimuli. The adapting stimuli induced changes in the perceived speed of a standard reference stimulus moving at 10 deg/s. In the absence of rTMS, adaptation to the slower stimulus led to an increase in perceived speed of the reference, whilst adaptation to the faster stimulus produced a reduction in perceived speed. These induced changes in speed

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10

Kikuchi, Tetsuhiro. "Survival of human induced pluripotent stem cell-derived midbrain dopaminergic neurons in the brain of a primate model of Parkinson's disease." Kyoto University, 2012. http://hdl.handle.net/2433/159389.

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11

Stanslowsky, Nancy [Verfasser]. "Functional differentiation of midbrain neurons from human cord blood-derived induced pluripotent stem cells for transplantation in a rat model of Parkinson’s disease / Nancy Stanslowsky." Hannover : Bibliothek der Tierärztlichen Hochschule Hannover, 2014. http://d-nb.info/106527730X/34.

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12

Kowalski, Alexandra [Verfasser], and Mathias [Akademischer Betreuer] Hafner. "Development of a quick, robust and chemically-defined differentiation protocol from human induced pluripotent stem cells towards cortical neurons to phenotype Alzheimer’s Disease / Alexandra Kowalski ; Betreuer: Mathias Hafner." Heidelberg : Universitätsbibliothek Heidelberg, 2020. http://d-nb.info/1211258866/34.

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13

Lefebvre, Omar Cynthia. "Défauts intrinsèques de motoneurones spinaux dérivés de cellules souches pluripotentes induites issues d’individus atteints de différentes formes de Sclérose Latérale Amyotrophique." Thesis, Sorbonne université, 2018. http://www.theses.fr/2018SORUS507.

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La Sclérose Latérale Amyotrophique (SLA) est une maladie neurodégénérative caractérisée par la mort des motoneurones (MNs). Malgré plusieurs hypothèses pouvant expliquer les mécanismes à l’origine de leur mort sélective, l’hétérogénéité de la SLA rend difficile la compréhension des causes exactes de la dégénérescence. Dans ce contexte, les cellules souches pluripotentes induites humaines (iPSC) permettent l’étude des formes familiales de la maladie comme des formes sporadiques. Contrairement à la majorité des travaux publiés à ce jour qui étudient des iPSC de patients porteurs de mutation dans

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14

Bélair, Caroline. "Ab1-42 and Ab1-40 induce tau phosphorylation in human neurons." Thesis, McGill University, 1997. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=27279.

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Alzheimer's disease is characterized by (1) senile plaques formed of aggregated amyloid peptides of 40 to 42 amino acids (A$ beta sb{1-40}$ and A$ beta sb{1-42}$) which are derived from the metabolism of the amyloid precursor protein, (2) by neurofibrillary tangles involving a dysfunction of the cytoskeleton due to the hyperphosphorylation of the tau protein, and (3) by amyloid-laden cerebral vessels. The goal of this project is to determine if there is a link between the presence of aggregated amyloid peptides and tau hyperphosphorylation.<br>We incubated the human fetal primary neuron cultur

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Bélair, Caroline. "A-ß¦1¦-¦4¦2 and A-ß¦1¦-¦4¦0 induce tau phosphorylation in human neurons." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape16/PQDD_0007/MQ29653.pdf.

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16

Lojewski, Xenia. "In vitro modeling of neuronal ceroid lipofuscinosis (NCL): Patient fibroblasts and their reprogrammed derivatives as human models of NCL." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2013. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-118812.

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The discovery of resetting human somatic cells via introduction of four transcription factors into an embryonic stem cell-like state that enables the generation of any cell type of the human body has revolutionized the field of medical science. The generation of patient-derived iPSCs and the subsequent differentiation into the cells of interest has been, nowadays, widely used as model system for various inherited diseases. The aim of this thesis was to generate iPSCs and to subsequently derive NPCs which can be differentiated into neurons in order to model the two most common forms of the NCL

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17

Yulius, Hermanto. "Transplantation of feeder-free human induced pluripotent stem cell-derived cortical neuron progenitors in adult male Wistar rats with focal brain ischemia." Kyoto University, 2019. http://hdl.handle.net/2433/242389.

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18

DEDONI, SIMONA. "Type I Interferon-induced neuronal damage: a study of the cellular and molecular mechanisms mediating interferon neurotoxicity." Doctoral thesis, Università degli Studi di Cagliari, 2011. http://hdl.handle.net/11584/266276.

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Type I interferons (IFNs) are known to cause neuropsychiatric side effects, including cognitive and mood disturbances, through mechanisms still not completely defined. To gain more information about type I IFN neurotoxicity, I investigated whether these cytokines could act directly on neuronal cells and regulate intracellular signaling pathways involved in cell death. In primary cultures of mouse cortical neurons acute exposure to IFN-β induces a marked tyrosine phosphorylation of signal transducer and activator of transcription (STAT) 1 and 3, whereas long-term exposure to the cytokine

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Canals, Montferrer Isaac. "Genetic and molecular analysis or Sanfilippo C syndrome. Generation of a neuronal model using human induced pluripotent stem (iPS) cells and therapeutic strategies." Doctoral thesis, Universitat de Barcelona, 2015. http://hdl.handle.net/10803/291819.

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Sanfilippo C syndrome is a lysosomal storage disorder that presents an autosomal recessive inheritance pattern and is caused by mutations in the HGSNAT gene, identified in 2006 in the chromosome 8. This gene codes for a lysosomal transmembrane protein, acetyl-CoA α-glucosaminide N-acetyltransferase, which acetylates the terminal glucosamine in the heparan sulfate chain during its degradation, a crucial step previous to the action of the next enzyme of the pathway. Heparan sulfate is a glycosaminoglycan localized in the extracellular matrix being part of proteoglycans and participate in several

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Mazaleyrat, Kilian. "Modélisation de pathologies neuromusculaires par la co-différenciation dirigée de cellules souches pluripotentes induites, en fibres musculaires innervées par des motoneurones." Thesis, Aix-Marseille, 2020. http://www.theses.fr/2020AIXM0127.

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Les cellules souches pluripotentes induites obtenues par reprogrammation des cellules somatiques primaires ont révolutionné les domaines de la biologie cellulaire et de la modélisation des maladies. Cependant, la modélisation des maladies musculaires squelettiques et neuromusculaires humaines a été entravée par un nombre limité de protocoles pour la génération de fibres musculaires matures avec une organisation sarcolemmale. Par co-différenciation simultanée de hiPSC dans les cellules musculaires et les motoneurones, nous avons développé une nouvelle procédure pour générer des fibres musculair

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Kapoor, Varun. "Mechanism of reversal of Alzheimer's disease A-beta induced neuronal degeneration in cultured human SHSY cells using a neurotrophic ependymin mimetic." Link to electronic thesis, 2007. http://www.wpi.edu/Pubs/ETD/Available/etd-071607-181533/.

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22

Louçã, Mathilde. "Functional impacts of Huntingtin lowering on the synaptic maturation and activity of neuronal networks derived from human induced pluripotent stem cells." Electronic Thesis or Diss., université Paris-Saclay, 2024. http://www.theses.fr/2024UPASL054.

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La maladie de Huntington (MH) est une maladie neurodégénérative causée par la mutation de la Huntingtine (HTT). La réduction de l'expression de la HTT mutante est une piste thérapeutique évidente en cours d’exploration chez les patients. Le ciblage de la HTT mutante s’accompagne cependant le plus souvent d’une réduction concomitante de la HTT non mutée. Les conséquences de la perte de cette protéine sur la santé des neurones restent mal connues.Mon travail de thèse traite cette question en utilisant des modèles in vitro de réseaux neuronaux humains différenciés à partir de cellules souches ind

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MUZZI, LORENZO. "Development of engineered human-derived brain-on-a-chip models for electrophysiological recording." Doctoral thesis, Università degli studi di Genova, 2022. http://hdl.handle.net/11567/1091007.

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The study of the central nervous system represents a great challenge in the field of neuroscience. For years, various techniques have been developed to study neuronal cells in-vitro as it is difficult to conduct in-vivo experiments due to ethical problems deriving from its anatomical location. Consequently, both in-vivo and in-vitro animal models have been used extensively to gain new insights into basic functioning principles of neuronal tissue and therapeutic approaches for brain diseases. Over time, we have seen that there is a poor correlation between the clinical diagnosis and the underly

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kapoor, varun. "Mechanism of Reversal of Alzheimerâ€™s Disease A-beta Induced Neuronal Degeneration in Cultured Human SHSY Cells Using A Neurotrophic Ependymin Mimetic." Digital WPI, 2007. https://digitalcommons.wpi.edu/etd-theses/908.

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"Alzheimerâ€™s disease (AD) is a neurodegenerative disorder that leads to dementia in adults. The mechanism of neurodegeneration is thought to involve the extracellular production of a highly toxic A-beta peptide that engages cell surface receptors to induce cellular oxidative stress and apoptosis, but the signal transduction pathways that lead to A-beta induced cell death are unknown. We previously showed that a human ependymin neurotrophic peptide mimetic (hEPN-1) can promote cell survival in an in vitro AD model system. This initial observation was extended in this thesis by investigatin

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Shin, Soojung. "Induced differentiation of human embryonic stem cells toward motor neurons." 2004. http://purl.galileo.usg.edu/uga%5Fetd/shin%5Fsoojung%5F200412%5Fphd.

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Mohan, Shekher. "Signaling pathways involved in il-1beta-induced regulation of MOR Expression in human neurons." 2008. http://digital.library.okstate.edu/etd/mohan_okstate_0664d_10126.pdf.

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Agbay, Andrew. "Development of guggulsterone-releasing microspheres for directing the differentiation of human induced pluripotent stem cells into neural phenotypes." Thesis, 2017. https://dspace.library.uvic.ca//handle/1828/8316.

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In the case of Parkinson’s disease, a common neurodegenerative disorder, the loss of motor function results from the selective degeneration of dopaminergic neurons (DNs) in the brain. Current treatments focus on pharmacological approaches that lose effectiveness over time and produce unwanted side effects. A more complete concept of rehabilitation to improve on current treatments requires the production of DNs to replace those that have been lost. Although pluripotent stem cells (PSCs) are a promising candidate for the source of these replacement neurons, current protocols for the terminal dif

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Matias, Dino Emanuel Santos. "Human neurons derived from induced pluripotent stem cells: a platform for screening compounds to treat Gaucher´s disease and Parkinson's disease." Doctoral thesis, 2020. http://hdl.handle.net/10400.1/16730.

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A doença de Gaucher (Gaucher disease – GD) é a doença lisossomal com maior taxa incidência em todo o mundo (Mistry et al., 2017). As doenças de armazenamento lisossomal, são um grupo de doenças metabólicas hereditárias caracterizadas pela redução de atividade ao longo de uma via metabólica, levando à acumulação de um ou mais dos seus substratos, e consequente desregulação celular. GD é causada por níveis reduzidos de atividade da hidrolase β-glucocerebrosidase (GCase), o que pode ocorrer por mutações no centro ativo, alterações no processamento, no ativador ou nos transportadores. A doe

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Lin, Yi-Chien, and 林怡倩. "Neuroprotective effects of ugonin K and furopyrazole derivatives on hydrogen peroxide-induced apoptosis in human neuroblastoma SH-SY5Y cells and C2 ceramide-induced apoptosis in primary cortical neurons." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/62785773575572533150.

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博士<br>中國醫藥大學<br>藥物化學研究所博士班<br>97<br>Oxidative stress is widely implicated in the neuron cell death that is associated with various neurodegenerative disorders such as Parkinson’s disease and Alzheimer’s disease. Ugonin K, a flavonoid isolated from the rhizomes of Helminthostachys zeylanica (L) Hook, possesses potent antioxidant property. In this study, we investigate the neuroprotective effects of ugonin K on hydrogen peroxide-induced apoptosis in SH-SY5Y cells. Incubation of SH-SY5Y cells with H2O2 for 24 h induced cell death measured with MTT assay. Hoechst 33258 staining confirmed that the

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Liu, Jen-Wei, and 劉人瑋. "Regulation of Stat3 and Erk1/2 in mouse embryonic stem cells and exploring the feasibility of reprogramming human cells to induced neurons." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/17475134663847693196.

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博士<br>國立中興大學<br>生命科學系所<br>102<br>In regular culture conditions with leukemia inhibitory factor (LIF), the majority of mouse embryonic stem cells (mESCs) are maintained in a self-renewal stage; very few mESCs have differentiated morphology. When LIF is withdrawn, mESCs tend to differentiate; this differentiation process can be enhanced by the introduction of exogenous FGF. Here, we show that even in the presence of exogenous FGF1, mESCs can maintain self-renewal and expression of pluripotency markers in the presence of LIF. To elucidate the mechanism in which LIF dominates over FGF1, extracellu

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Chen, Pei-Ying, та 陳姵穎. "Recapitulating the cytopathological features of Alzheimer’s disease in the neurons from β-amyloid genetic modified human embryonic stem cells and trisomy induced-pluripotent stem cells". Thesis, 2014. http://ndltd.ncl.edu.tw/handle/7v78pm.

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碩士<br>國立中興大學<br>生命科學系所<br>102<br>The accumulation of β-amyloid (Aβ), produced by endoproteolysis of the amyloid precursor protein (APP), results in amyloid plaques formation and is the cytopathological hallmark in the patient’s brain of Alzheimer’s disease (AD). To generate the AD cell model by in vitro differentiation of pluripotent stem cells, initially, we attempt to use APP-transgenic human embryonic stem cells (hESCs) as a platform for studying amyloid plaques associated diseases. Dual Oct4 and α-Tubulin promoters driving the neomycin-2A-green fluorescent protein (NeoGFP) and APP protein,

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Hsu, Jin-Ran, and 許景然. "Involvement of Extracellular Signal-Regulated Kinase in Retinoic Acid-Induced Human Neuronal Differentiation." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/83769602770152889260.

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碩士<br>國立成功大學<br>細胞生物及解剖學研究所<br>91<br>Neuronal differentiation in the mammalian CNS is driven by multiple events. Mitogen activated protein kinases (MAPKs) have been observed to play roles in neuronal development. It have been demonstrated that hNT-2 cells (NT2 cells), a cell-line derived from human teratocarcinoma, act as be a good model for study neuronal development. Following retinoic acid (RA) treatment, NT-2 cells can differentiate into postmitotic neuronal cells and express several mature neuronal markers. In this thesis, during period of RA induction, phosphorylated form of extracellula

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Nardiello, Pamela. "Nutraceutical approaches against amyloid-β induced neuropathology: an in vivo and in vitro study". Doctoral thesis, 2018. http://hdl.handle.net/2158/1119237.

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ABSTRACT Introduction: Mounting evidence supports the beneficial effects of the Mediterranean diet (MD) and the Asian diet in delaying ageing and in preventing age-related dysfunctions, cancer, diabetes and neurodegenerative diseases. The beneficial effects of the MD and Asian diets in reducing age-related dysfunctions, including Alzheimer’s disease (AD), could be the consequence of the presence in specific foods of substantial amounts of specific polyphenols whose beneficial properties include the ability to interfere with amyloid aggregation. Our previous data have highlighted the benefi

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Hall, Meghan. "Mathematical model of growth and neuronal differentiation of human induced pluripotent stem cells seeded on melt electrospun biomaterial scaffolds." Thesis, 2016. http://hdl.handle.net/1828/7459.

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Human induced pluripotent stem cells (hiPSCs) have two main properties: pluripotency and self-renewal. Physical cues presented by biomaterial scaffolds can stimulate differentiation of hiPSCs to neurons. In this work, we develop and analyze a mathematical model of aggregate growth and neural differentiation on melt electrospun biomaterial scaffolds. An ordinary differential equation model of population size of each cell state (stem, progenitor, differentiated) was developed based on experimental results and previous literature. Analysis and numerical simulations of the model successfully

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Lojewski, Xenia. "In vitro modeling of neuronal ceroid lipofuscinosis (NCL): Patient fibroblasts and their reprogrammed derivatives as human models of NCL." Doctoral thesis, 2012. https://tud.qucosa.de/id/qucosa%3A27067.

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The discovery of resetting human somatic cells via introduction of four transcription factors into an embryonic stem cell-like state that enables the generation of any cell type of the human body has revolutionized the field of medical science. The generation of patient-derived iPSCs and the subsequent differentiation into the cells of interest has been, nowadays, widely used as model system for various inherited diseases. The aim of this thesis was to generate iPSCs and to subsequently derive NPCs which can be differentiated into neurons in order to model the two most common forms of the NCL

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Ho, Chia-Ling, and 何佳玲. "Quercetin protects human neuronal SH-SY5Y cells against oxidative stress-induced damage by increasing mitochondrial biogenesis and reducing free radicals." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/sfrg48.

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碩士<br>臺北醫學大學<br>保健營養學研究所<br>102<br>Background： Present studies suggested that lack of mitochondrial biogenesis in Alzheimer’s disease patient’s brain. Quercetin, has been shown to increase mitochondrial biogenesis. Purpose：Our purpose was to exam whether quercetin can increase mitochondrial biogenesis to ameliorate beta amyloid accumulation in H2O2-induced SH-SY5Y neuron cell. Methods: SH-SY5Y cell were treated H2O2 to induce oxidative stress. We pretreated 0, 2.5, 5, 7.5, 10 μM quercetin then to analyze the cellular mitochondrial biogenesis, ATP production and cell apoptosis in H2O2 induced c

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Lin, Chun-Yi, та 林君怡. "Inducible Nitric Oxide Synthase Gene Expression in Human Microglia Cells Induced with β-Amyloid as A Model for Screening Neuron Protection Lead Compounds". Thesis, 2009. http://ndltd.ncl.edu.tw/handle/10930676131581005454.

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碩士<br>輔仁大學<br>生命科學系碩士班<br>97<br>Alzheimer's disease ( AD ) is a progressive neurodegenerative disorder and characterized with the cerebral deposition of senile plaque which arises from the abnormal accumulation of -amyloid ( A). A is a peptide of 39–43 amino acids from cleavage of the amyloid precursor protein ( APP ). Several evidences indicate that A-activated microglia cells are involved in the neuropathology observed in AD. High levels of inducible nitric oxide synthase ( iNOS ) and nitric oxide ( NO ) have been detected in microglial cells of AD patients and cause neurons death. Epid

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Liao, Yu-Ting, та 廖宇婷. "Protective effect of solid-state fermented crops by Ganoderma lucidum against oxidation stress and β-amyloid plaques induced damage in human neuron cells". Thesis, 2018. http://ndltd.ncl.edu.tw/handle/y5frm5.

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碩士<br>國立臺灣海洋大學<br>食品科學系<br>106<br>Alzheimer's disease is a neurodegenerative disease caused by the stacked of β-amyloid peptides. Our laboratory has established the culture medium and condition for the solid-state cultivation of G.lucidum mycelia. This study investigated the protective effect of solid-state fermented crops by G.lucidum against oxidation stress caused by H2O2 and Aβ25-35 in neuroblastoma SH-SY5Y cell line. Various extracts by 10% ethanol extraction using microwave (A), 70oC water extraction (B) and 100oC water extraction followed by ethanol precipitation (C) of G.lucidum fermen

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Ni, Mei-Hui, and 倪美惠. "Role of GSK-3 in the okadaic acid-induced phosphorylation of CRMP-2 and characterization of a CRMP-2 variant, CRMP-2L, in human neuronal and non-neuronal cell lines." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/14592244843881351915.

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博士<br>長庚大學<br>生物醫學研究所<br>97<br>Collapsin response mediator protein-2 (CRMP-2), a phosphoprotein involved in axonal outgrowth and microtubule dynamics, is aberrantly phosphorylated in Alzheimer disease (AD) brain. Alteration of glycogen synthase kinase-3 (GSK-3) activity is associated with the pathogenesis of AD. CRMP-2 is highly expressed in the developing nervous system. It is believed that CRMP-2 is a neuronal tissue-specific protein, however, its expression in non-neuronal cells has not been investigated clearly. Here I demonstrate that CRMP-2 is not only expressed in neuronal cells but als

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Henriques, Laeticia. "Assessment of lesion-induced network connectivity disruption in the human brain: application to a context of pre-surgical planning." Master's thesis, 2020. http://hdl.handle.net/10451/45263.

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Tese de mestrado integrado, Engenharia Biomédica e Biofísica (Engenharia Clínica e Instrumentação Médica) Universidade de Lisboa, Faculdade de Ciências, 2020<br>Neurosurgery has been considered as a treatment or a therapy option for brain lesions with satisfactory outcomes regarding the maximal resection of the lesioned area and the minimal post-surgical neurological dysfunctions by avoiding eloquent areas. For the last two decades, resting-state functional magnetic resonance imaging (rs-fMRI) has emerged as an effective non-invasive neuro-imaging technique that can be used for pre-surgical fu

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Konopacki, F. A., N. Jaafari, D. L. Rocca, et al. "Agonist-induced PKC phosphorylation regulates GluK2 SUMOylation and kainate receptor endocytosis." 2011. http://hdl.handle.net/10454/6054.

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No<br>The surface expression and regulated endocytosis of kainate (KA) receptors (KARs) plays a critical role in neuronal function. PKC can modulate KAR trafficking, but the sites of action and molecular consequences have not been fully characterized. Small ubiquitin-like modifier (SUMO) modification of the KAR subunit GluK2 mediates agonist-evoked internalization, but how KAR activation leads to GluK2 SUMOylation is unclear. Here we show that KA stimulation causes rapid phosphorylation of GluK2 by PKC, and that PKC activation increases GluK2 SUMOylation both in vitro and in neurons. The intra

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