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Relevant bibliographies by topics / Human Liver Stem Cells. Liver Ischemia Repercussion Injury. Normothermic Machine Perfusion

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Journal articles
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Academic literature on the topic 'Human Liver Stem Cells. Liver Ischemia Repercussion Injury. Normothermic Machine Perfusion'

Author: Grafiati

Published: 14 March 2023

Last updated: 31 July 2025

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Journal articles on the topic "Human Liver Stem Cells. Liver Ischemia Repercussion Injury. Normothermic Machine Perfusion"

1

De Stefano, Nicola, Alberto Calleri, Victor Navarro-Tableros, Federica Rigo, Damiano Patrono, and Renato Romagnoli. "State-of-the-Art and Future Directions in Organ Regeneration with Mesenchymal Stem Cells and Derived Products during Dynamic Liver Preservation." Medicina 58, no. 12 (2022): 1826. http://dx.doi.org/10.3390/medicina58121826.

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Transplantation is currently the treatment of choice for end-stage liver diseases but is burdened by the shortage of donor organs. Livers from so-called extended-criteria donors represent a valid option to overcome organ shortage, but they are at risk for severe post-operative complications, especially when preserved with conventional static cold storage. Machine perfusion technology reduces ischemia-reperfusion injury and allows viability assessment of these organs, limiting their discard rate and improving short- and long-term outcomes after transplantation. Moreover, by keeping the graft me

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Tian, Xuan, Huan Cao, Longlong Wu, et al. "Heme Oxygenase-1-Modified Bone Marrow Mesenchymal Stem Cells Combined with Normothermic Machine Perfusion Repairs Bile Duct Injury in a Rat Model of DCD Liver Transplantation via Activation of Peribiliary Glands through the Wnt Pathway." Stem Cells International 2021 (July 1, 2021): 1–17. http://dx.doi.org/10.1155/2021/9935370.

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Livers from donors after circulatory death (DCD) are inevitably exposed to a longer warm ischemic period, which might increase the incidence of postoperative bile duct complications. Bone marrow mesenchymal stem cells (BMMSCs) have tissue repair properties. The present study was aimed at exploring the repair effect of heme oxygenase-1- (HO-1-) modified BMMSCs (HO-1/BMMSCs) combined with normothermic machine perfusion (NMP) on bile duct injury after DCD liver transplantation and at revealing the underlying mechanisms. Rat livers were exposed to in situ warm ischemia for 30 min; then, NMP was pe

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3

De Stefano, Nicola, Victor Navarro‐Tableros, Dorotea Roggio, et al. "Human liver stem cell‐derived extracellular vesicles reduce injury in a model of normothermic machine perfusion of rat livers previously exposed to a prolonged warm ischemia." Transplant International 34, no. 9 (2021): 1607–17. http://dx.doi.org/10.1111/tri.13980.

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4

Abbas, Syed Hussain, Carlo D. L. Ceresa, Leanne Hodson, et al. "Defatting of donor transplant livers during normothermic perfusion—a randomised clinical trial: study protocol for the DeFat study." Trials 25, no. 1 (2024). http://dx.doi.org/10.1186/s13063-024-08189-4.

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Abstract Background Liver disease is the third leading cause of premature death in the UK. Transplantation is the only successful treatment for end-stage liver disease but is limited by a shortage of suitable donor organs. As a result, up to 20% of patients on liver transplant waiting lists die before receiving a transplant. A third of donated livers are not suitable for transplant, often due to steatosis. Hepatic steatosis, which affects 33% of the UK population, is strongly associated with obesity, an increasing problem in the potential donor pool. We have recently tested defatting intervent

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Dissertations / Theses on the topic "Human Liver Stem Cells. Liver Ischemia Repercussion Injury. Normothermic Machine Perfusion"

1

CATALANO, GIORGIA. "Human liver stem cells and derived products in experimental models of liver ischemia reperfusion injury and of liver isolated normothermic perfusion." Doctoral thesis, Politecnico di Torino, 2018. http://hdl.handle.net/11583/2711047.

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Ischemia reperfusion injury (IRI) is an antigen-independent inflammatory event that affects several clinical settings, including surgical procedures such as liver resection and liver transplantation. IRI is still a major concern in the transplantation setting, causing up to 10% of early graft failure and leading to a higher incidence of acute and chronic rejection. IRI is initiated by Kuppfer cells and hepatocytes through a massive production of reactive oxygen species (ROS) during the ischemic phase and, in a major degree, during the post-reperfusion phase. ROS directly damage hepatocyte

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