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Relevant bibliographies by topics / Human Mutagenesis / Dissertations / Theses

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Dissertations / Theses on the topic 'Human Mutagenesis'

Author: Grafiati

Published: 4 June 2021

Last updated: 3 February 2022

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1

Warburton, Johnny. "Selection and mutagenesis in cultured African violet plantlets." Thesis, University of Edinburgh, 1986. http://hdl.handle.net/1842/11945.

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2

Gan, Shu Uin. "Retroviral insertional mutagenesis of human myeloid HL-60 cells." Thesis, King's College London (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.244680.

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3

Kozlenkov, Alexey. "Structural/functional studies on human alkaline phosphatases /." Umeå : Univ, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-136.

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4

Leontiou, Chrysoula. "Mechanisms of drug resistance to acridine derivatives mediated by human DNA topoisomerase IIÎ²." Thesis, University of Newcastle Upon Tyne, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.273685.

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5

Gebhard, Daniel [Verfasser]. "Solar-induced mitochondrial mutagenesis and dysfunction in human skin / Daniel Gebhard." Konstanz : Bibliothek der Universität Konstanz, 2014. http://d-nb.info/1081016450/34.

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6

Ellis, James. "Structural analysis of the human angiotensin type 1 receptor through mutagenesis." Thesis, University of Leeds, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.418731.

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7

Clapham, Peter C. "The radiobiology of human colorectal cell lines : an investigation into transformation and radiosensitivity." Thesis, University of Bristol, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.265322.

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8

Nie, Mei. "The transcriptional regulation of the human IL-8 and MCP-1 genes in cultured primary mesangial cells." Thesis, University of Nottingham, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368257.

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9

Wang, Jen-Yeu. "Human PC4 Prevents Mutagenesis and Killing by Oxidative DNA Damage: a Dissertation." eScholarship@UMMS, 2012. http://escholarship.umassmed.edu/gsbs_diss/287.

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Chapter II Abstract Human positive cofactor 4 (PC4) is a transcriptional coactivator with a highly conserved single-strand DNA (ssDNA) binding domain of unknown function. We identified PC4 as a suppressor of the oxidative mutator phenotype of the Escherichia coli fpg mutY mutant and demonstrate that this suppression requires its ssDNA binding activity. Saccharomyces cerevisiae mutants lacking their PC4 ortholog Sub1 are sensitive to hydrogen peroxide and exhibit spontaneous and peroxide-induced hypermutability. PC4 expression suppresses the peroxide sensitivity of the yeast sub1Δ mutant, sugge

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10

Wang, Jen-Yeu. "Human PC4 Prevents Mutagenesis and Killing by Oxidative DNA Damage: a Dissertation." eScholarship@UMMS, 2004. https://escholarship.umassmed.edu/gsbs_diss/287.

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Chapter II Abstract Human positive cofactor 4 (PC4) is a transcriptional coactivator with a highly conserved single-strand DNA (ssDNA) binding domain of unknown function. We identified PC4 as a suppressor of the oxidative mutator phenotype of the Escherichia coli fpg mutY mutant and demonstrate that this suppression requires its ssDNA binding activity. Saccharomyces cerevisiae mutants lacking their PC4 ortholog Sub1 are sensitive to hydrogen peroxide and exhibit spontaneous and peroxide-induced hypermutability. PC4 expression suppresses the peroxide sensitivity of the yeast sub1Δ mutant, sugge

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11

Mesa, Solís Julio. "Human prostaglandin reductase 1 (PTGR1): Substrate specificity, site-directed mutagenesis and catalytic mechanism." Doctoral thesis, Universitat Autònoma de Barcelona, 2016. http://hdl.handle.net/10803/394081.

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12

Kwok, Colin, and 郭浩然. "A study of the quaternary structure of human glucose-6-phosphate dehydrogenase (G6PD)." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B31245468.

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13

Neal, Jessica A. "The role of human Rev7, the accessory subunit of human DNA polymerase zeta, in cell survival and DNA damage induced mutagenesis." Diss., Connect to online resource - MSU authorized users, 2008.

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14

Alhadrami, Hani Abdullah. "Development and applications of mutagenicity and carcinogenicity bioassays for human health risk assessment." Thesis, University of Aberdeen, 2011. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=166645.

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Young children are particularly sensitive to environmental pollutants. They can directly ingest soil by putting dirty hands and objects in their mouths. The reliance on animal derived models for human health risk and exposure assessment has several limitations. In this investigation, a tool-kit was developed and optimised to facilitate more accurate, reliable and representative predictions of soil contaminants that might pose a significant hazard to young children. The tool-kit was developed and optimised using an in vitro human digestion bioassay. This procedure was followed by the optimisati

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15

Strege, Annette. "Thermostabilisation of the human CRF1 receptor in the presence of an agonist and a G protein." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/277504.

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16

Plona, Kathleen Lynn. "ROLE OF A CONSERVED AMINO ACID MOTIF IN LOCALIZATION OF HUMAN CLIC5 TO MICROVILLI." Ohio University Art and Sciences Honors Theses / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=ouashonors1340830402.

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17

Li, Min. "Site-directed mutagenesis of the branchpoint sequence of intron 4 of the human lecithin : cholesterol acyltransferase gene." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0019/NQ56575.pdf.

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18

Verghis, Susan Bina Malaikal 1960. "Investigation of the mechanism of mutagenesis by the DNA adducts of the human bladder carcinogen, 4-aminobiphenyl." Thesis, Massachusetts Institute of Technology, 1992. http://hdl.handle.net/1721.1/73326.

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19

Silvers, Kimberly Jane. "The role of cytochrome P450-mediated C-oxidation and cytosolic nitroreduction in the metabolism, DNA binding, and mutagenicity of 1-nitropyrene in human liver." Case Western Reserve University School of Graduate Studies / OhioLINK, 1995. http://rave.ohiolink.edu/etdc/view?acc_num=case1062512189.

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20

Elangwe, Emilia N. "Site Directed Mutagenesis, Expression and Enzymatic Studies of the 60 kDa Human HIV-TAT 1 Interactive Protein, TIP60." Digital Archive @ GSU, 2009. http://digitalarchive.gsu.edu/chemistry_theses/21.

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Tip60 is a 60 kDa nuclear protein which exists in three isoforms, belongs to the MYST/HAT family of proteins and was discovered after its interaction with the Human HIV-1 Tat. As a nuclear protein, Tip60 can act as a coactivator or repressor. To understand the HAT action of Tip60, two possible catalytic models exist; the ping-pong and the ternary complex formation models. In correlation with the exploration of HAT catalytic action, mutations of a Cys to Ala and a Glu to Gln on Esa1 (yeast homolog of Tip60 and MYST/HAT prototype), was reported to show wild type-like and decreased acetylating pr

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21

Siderovski, David Peter. "Human immunodeficiency virus type-1 trans-activator of transcription (HIV-1 Tat), random mutagenesis and interaction with PKR." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape16/PQDD_0004/NQ27724.pdf.

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22

Garner, Joanne Clare. "Site directed mutagenesis, autoprocessing and inhibitor studies on the retroviral protease of the human immunodeficiency virus type-1." Thesis, University of Southampton, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.302318.

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23

Lifton, Samuel Robert. "Retroviral mutagenesis in a newly developed myc transgenic mouse model of human B cell and plasma cell neoplasia." Thesis, University of Iowa, 2013. https://ir.uiowa.edu/etd/1479.

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Three potential driver genes were identified by use of retroviral mutagenesis in the newly developed iMyc model of B cell malignancy. To do so, iMyc mice, which bear an inserted copy of c-Myc in the IgH locus, were treated with MOL4070LTR to favor the development of B cell malignancies. After tumor development, B cell origin tumors were identified by use of immunohistochemistry and selected for downstream analysis. Three genes were chosen as potential driver genes and validated in mouse or human disease as involved in disease or directly in malignancy. These genes are CD82, IRAK2 and DNMT3a.

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24

Krebs, Stefan Ralf. "Nonnatural ligands for the human leukocyte antigen HLA-B27 : protein expression, site-directed mutagenesis, peptide syntheses and binding studies." Zürich, 1997. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=12426.

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25

Hey, Peter. "Characterisation of mariner type transposons in the human opportunistic pathogen Aspergillus fumigatus and development of tagged transposon mutagenesis tools." Thesis, University of Manchester, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.686245.

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Aspergillus fumigatus is the foremost human pathogen of the genus Aspergillus. Current therapies are only partially effective and mortality rates still exceed 60%. All current anti› aspergillus drugs target cell wall and cell membrane components so the identification of novel drug targets may provide an avenue for development of drugs directed against other fungal cell sites. In this study native and non-native mariner transposable elements were investigated with the intention of using these for random mutagenesis, which when coupled with parasexual genetics can be used to identify essential g

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26

D'Aoust, Jean Philippe. "Identifying the roles of the amino terminal and first transmembrane regions of human D1-like dopaminergic receptors using mutagenesis." Thesis, University of Ottawa (Canada), 2009. http://hdl.handle.net/10393/28213.

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Although D1-like dopaminergic receptors (D1R and D5R) share similar primary sequences, they possess distinct ligand binding and G protein-coupling properties. Since no ligands discriminate the closely related D1R and D5R, the discovery of their subtype-specific functional and physiological functions is stalled. To provide additional conformational data about the binding pocket of D1-like receptors, we assessed the functional roles of their highly divergent amino terminal cassette. Using a chimerical approach, we swapped the extracellular amino terminal (NT) and first transmembrane (TM1) region

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27

Fällmar, Helena. "Studies of the Neuropeptide Y Receptor Y2 in Human and Zebrafish." Doctoral thesis, Uppsala universitet, Farmakologi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-156635.

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The G-protein coupled receptors (GPCRs) comprise the largest family of receptors in humans and other vertebrates. They are embedded in the cell membrane and are activated by many different signaling molecules. Activation modulates cellular signal transduction pathways and influences many physiological processes. Therefore the GPCRs are important as targets for numerous drugs. The receptors for NPY (neuropeptide Y) belong to GPCRs of Class A (rhodopsin-like). NPY and its related peptides PYY and PP are involved in the regulation of appetite, blood pressure and many other processes. They share a

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28

Knappenberger, Andrew John. "MOLECULAR DRIVERS OF SPECIFICITY IN HUMAN RIBONUCLEOTIDE REDUCTASE." Case Western Reserve University School of Graduate Studies / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=case1490722285574706.

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29

Pisil, Yalcin. "The Study on Neutralization of Human Immunodeficiency Virus and SARS CoV-2 - Neutralization Resistance of SHIV and Neutralization Assay for SARS CoV-2 -." Doctoral thesis, Kyoto University, 2021. http://hdl.handle.net/2433/264673.

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京都大学<br>新制・課程博士<br>博士(人間・環境学)<br>甲第23392号<br>人博第1005号<br>新制||人||237(附属図書館)<br>京都大学大学院人間・環境学研究科相関環境学専攻<br>(主査)准教授三浦智行, 教授川本卓男, 准教授西川完途<br>学位規則第4条第1項該当<br>Doctor of Human and Environmental Studies<br>Kyoto University<br>DFAM

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30

Davis, Elizabeth A. "Diverse environmental Pseudomonas encode unique secondary metabolites that inhibit human pathogens." Bowling Green State University / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1498481537530199.

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31

Turner, Joel G. "Human topoisomerase II alpha nuclear export is mediated by two Crm-1 dependent nuclear export signals." [Tampa, Fla.] : University of South Florida, 2004. http://purl.fcla.edu/fcla/etd/SFE0000258.

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32

Ousley, Amanda. "Engineering the human vitamin D receptor to bind a novel small molecule: investigating the structure-function relationship between human vitamin d receptor and various ligands." Diss., Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/39580.

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The human vitamin D receptor (hVDR) is a member of the nuclear receptor superfamily, involved in calcium and phosphate homeostasis; hence implicated in a number of diseases, such as Rickets and Osteoporosis. This receptor binds 1α,25-dihydroxyvitamin D3 (also referred to as 1,25(OH)2D3) and other known ligands, such as lithocholic acid. Specific interactions between the receptor and ligand are crucial for the function and activation of this receptor, as implied by the single point mutation, H305Q, causing symptoms of Type II Rickets. In this work, further understanding of the significant an

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33

Dedek, Matthew Milan. "The Melanocortin System: Structure Activity Relationships of Alpha-N-Methylated MT-II Analogues and Mutation Studies of Human Melanocortin Receptor Subtypes 1 and 4." Thesis, The University of Arizona, 2007. http://hdl.handle.net/10150/193306.

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The melanocortin system regulates various physiological processes including feeding behavior, sexual function, skin pigmentation and photoprotection via five G-protein coupled receptors and several endogenous ligands. There is a need for selective and potent ligands to the human melanocortin receptors (hMCRs) that can chemically resolve these various functions. This thesis presents three studies aimed at refining the understanding of the structural differences between binding pockets of the hMCR subtypes. In the first study α-N-methylated analogues of the non-selective agonist, MT-II, are eval

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34

Stuckey, Samantha Anne. "Gene targeting at and distant from DNA breaks in yeast and human cells." Diss., Georgia Institute of Technology, 2013. http://hdl.handle.net/1853/51721.

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Here we developed multiple genetic systems through which genetic modifications driven by DNA breaks caused by the I-SceI nuclease can be assayed in the yeast Saccharomyces cerevisiae and in human cells. Using the delitto perfetto approach for site-directed mutagenesis in yeast, we generated isogenic strains in which we could directly compare the recombination potential of different I-SceI variants. By genetic engineering procedures, we generated constructs in human cells for testing the recombination activity of the same I-SceI variants. Both in yeast and human cells we performed gene correcti

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35

Romani, Bizhan. "Mutagenesis and functional studies of the HIV-1 vpr gene and Vpr protein obtained from South African virus strains." Thesis, Stellenbosch : University of Stellenbosch, 2010. http://hdl.handle.net/10019.1/6702.

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Thesis (PhD)--University of Stellenbosch, 2011.<br>ENGLISH ABSTRACT: Background: Human immunodeficiency virus type 1 (HIV-1) viral protein R (Vpr) is an accessory protein that interacts with a number of host cellular and other viral proteins. Vpr exerts several functions such as induction of apoptosis, induction of cell cycle G2 arrest, modulation of gene expression, and suppression of immune activation. The functionality of subtype C Vpr, especially South African strains, has not been studied. The aim of this study was to describe the diversity of South African HIV-1 subtype C vpr genes

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36

Castillo, Hilda S. "Mutational analysis and engineering of the human vitamin D receptor to bind and activate in response to a novel small molecule ligand." Diss., Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/39502.

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Nuclear receptors (NRs) are ligand-activated transcription factors that regulate the expression of genes involved in all physiological activities. Disruption in NR function (e.g. mutations) can lead to a variety of diseases; making these receptors important targets for drug discovery. The ability to bind a broad range of 'drug-like' molecules also make these receptors attractive candidates for protein engineering, such that they can be engineered to bind novel small molecule ligands, for several applications. One application is the creation of potential molecular switches, tools that can be us

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37

Solaroli, Nicola. "Investigation of antiviral and anticancer nucleoside analog substrate recognition of drosophila melanogaster and herpes virus deoxyribonucleoside kinases /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-922-X/.

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38

Holmberg, Sara. "Neuropeptide Y Receptors in Human, Guinea pig and Chicken : Cloning, in vitro Pharmacology and in situ Hybridization." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2001. http://publications.uu.se/theses/91-554-5160-8/.

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39

Lai, Raymond E. "Elucidation of Substrate Binding Interactions for Human Organic Cation Transporters 1 (SLC22A1) and 2 (SLC22A2) Using In Silico Homology Modeling in Conjunction with In Vitro Site-Directed Mutagenesis and Kinetic Analysis." VCU Scholars Compass, 2018. https://scholarscompass.vcu.edu/etd/5593.

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The organic cation transporters (OCTs) play a critical role in the absorption, distribution and elimination of many drugs, hormones, herbal medicines, and environmental toxins. Given the broad substrate specificity of OCTs, they fall victim to the high susceptibility for contributing to harmful drug-drug interactions. Further defining how human (h)OCTs mechanistically bind to its broad array of substrates will provide significant insight to the understanding and prediction of drug-drug interactions in polypharmacy patients and the advancement of future rational drug design for therapeutics tar

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40

Bosch, i. Grau Montserrat. "Producció i caracterització de variants de la ribonucleasa pancreàtica humana dissenyades per a adquirir propietats citotòxiques." Doctoral thesis, Universitat de Girona, 2003. http://hdl.handle.net/10803/7612.

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Amb la finalitat d'aprofundir en les bases moleculars de la citotoxicitat de les ribonucleases pancreàtiques, es van construir variants derivades de l'HP-RNasa seguint dues estratègies. En la primera, es van generar variants de l'enzim resistents a l'acció de l'inhibidor proteic de les ribonucleases (hRI), substituint residus implicats en la interfície de contacte entre la ribonucleasa i l'hRI. En la segona, es va addicionar el motiu RGD en regions de superfície de la proteïna implicades en la formació del complex amb l'hRI, a fi de promoure la seva interacció amb la membrana plasmàtica de les

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41

Kazmin, Roman. "FTIR-spektroskopische Untersuchungen zum Aktivierungsmechanismus von bovinem und humanem Rhodopsin." Doctoral thesis, Humboldt-Universität zu Berlin, Lebenswissenschaftliche Fakultät, 2015. http://dx.doi.org/10.18452/17279.

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Das aus dem Apoprotein Opsin und dem kovalent gebundenen Liganden bestehende Rhodopsin dient als Modellsystem für den Aktivierungsmechanismus der größten Klasse von G-Protein-gekoppelten Rezeptoren (GPCR). Infolge einer photochemischen Reaktion vollführt Rhodopsin eine Bewegungsabfolge von Sekundärstrukturelementen, wodurch es aktiviert wird, das G-Protein bindet und den Stimulus auf zellinterne Signalwege überträgt. Mithilfe der ortsspezifischen Mutagenese wurden Mutanten des bovinen Rhodopsins erzeugt, in eine künstliche Lipidumgebung eingelagert und hauptsächlich mittels FTIR-Spektroskopie

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42

Despres, Jordane. "Etude fonctionnelle des systèmes pectinolytiques et xylanolytiques de Bacteroides xylanisolvens, espèce bactérienne majeure du côlon de l'homme." Thesis, Clermont-Ferrand 2, 2015. http://www.theses.fr/2015CLF22614.

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Chez l’homme, la dégradation des fibres alimentaires est une des fonctions principales du microbiote colique. Elles ont de nombreux effets bénéfiques en santé humaine et pourtant les mécanismes microbiens mis en jeu dans leur dégradation restent encore largement méconnus. L’objectif de cette thèse était d’approfondir les connaissances sur la dégradation des polysaccharides pariétaux (hémicelluloses et pectines) par une espèce bactérienne prédominante du côlon de l’homme, Bacteroides xylanisolvens. L’analyse du transcriptome de B. xylanisolvens XB1AT a révélé l’existence de six et deux loci gén

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43

Sabatier, Laure. "Approche cytogenetique de la mutagenese radioinduite chez l'homme." Paris 6, 1988. http://www.theses.fr/1988PA066520.

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44

Díez, Fernández Carmen. "USING RECOMBINANT HUMAN CARBAMOYL PHOSPHATE SYNTHETASE 1 (CPS1) FOR STUDYING THIS ENZYME'S FUNCTION, REGULATION, PATHOLOGY AND STRUCTURE." Doctoral thesis, Universitat Politècnica de València, 2015. http://hdl.handle.net/10251/52855.

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[EN] Carbamoyl phosphate synthetase 1 (CPS1), a 1462-residue mitochondrial enzyme, catalyzes the entry of ammonia into the urea cycle, which converts ammonia, the neurotoxic waste product of protein catabolism, into barely toxic urea. The urea cycle inborn error and rare disease CPS1 deficiency (CPS1D) is inherited with mendelian autosomal recessive inheritance, being due to CPS1 gene mutations (>200 mutations reported), and causing life-threatening hyperammonemia. We have produced recombinantly human CPS1 (hCPS1) in a baculovirus/insect cell expression system, isolating the enzyme in active

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45

Layet, Corine. "Approche des bases structurales de l'antigenicite des antigenes hla de classe i." Aix-Marseille 2, 1986. http://www.theses.fr/1986AIX22046.

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46

Girault, Isabelle. "Identification et dosage immunologique de lésions de l'ADN." Grenoble 1, 1995. http://www.theses.fr/1995GRE10123.

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Divers facteurs (agents oxydants, rayonnements) peuvent engendrer des modifications de bases de l'adn. Le premier volet de ce travail de these a consiste a identifier les produits de degradation des bases pyrimidiques par l'ozone. L'identification de ces composes a permis de mettre en evidence deux nouveaux derives et de conclure a un mecanisme d'action specifique. La suite du travail concerne la preparation d'anticorps diriges contre des modifications de bases de l'adn. Nous avons mis au point une nouvelle methode de preparation des antigenes destines a la production d'anticorps utilises pour

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47

ARAÚJO, Daniella Bastos de. "Genotoxicidade humana e fármacos antidepressivos: avaliação da duloxetina em culturas de linfócitos." Universidade Federal do Pará, 2014. http://repositorio.ufpa.br/jspui/handle/2011/5437.

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Submitted by Cleide Dantas (cleidedantas@ufpa.br) on 2014-08-13T12:22:01Z No. of bitstreams: 2 license_rdf: 23898 bytes, checksum: e363e809996cf46ada20da1accfcd9c7 (MD5) Dissertacao_GenotoxicidadeHumanaFarmacos.pdf: 872023 bytes, checksum: ce96ad6961411bc1ee76a69bf1f29edc (MD5)<br>Approved for entry into archive by Irvana Coutinho (irvana@ufpa.br) on 2014-08-14T14:22:43Z (GMT) No. of bitstreams: 2 license_rdf: 23898 bytes, checksum: e363e809996cf46ada20da1accfcd9c7 (MD5) Dissertacao_GenotoxicidadeHumanaFarmacos.pdf: 872023 bytes, checksum: ce96ad6961411bc1ee76a69bf1f29edc (MD5)<br>Made av

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GAUDIN, PASCALE. "Le recepteur humain du vip de type 1 : analyse par mutagenese dirigee et chimerisme moleculaire." Paris 6, 1997. http://www.theses.fr/1997PA066345.

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Le but de ce travail a ete d'etudier la relation entre la structure et la fonction du recepteur humain du peptide vasoactif intestinal (vip) de type 1, un membre de la famille de classe ii des recepteurs couples aux proteines g. Nous avons entrepris la caracterisation du domaine de liaison du recepteur vip 1 a son agoniste naturel, le vip : 1) parmi les residus des domaines extracellulaires qui sont strictement conserves au sein de cette famille, la mutagenese dirigee a montre que trois acides amines, l'aspartate 68, le tryptophane 73 et la glycine 109, sont cruciaux pour la capacite du recept

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49

ROQUEPLO, GIMENEZ ANNE-PAULE. "Structure et fonction de l'angiotensionogene humain : etude des variants naturels et des variants obtenus par mutagenese dirigee." Paris 6, 1999. http://www.theses.fr/1999PA066440.

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L'angiotensinogene est le substrat unique et specifique de la renine. Il a ete recemment mis en evidence une relation positive entre le gene de l'angiotensinogene humain et l'hypertension arterielle essentielle. Nous avons realise l'etude des mutations naturelles du gene et caracterise la mutation y248c qui induit une glycosylation anormale de la proteine et un diminution de sa production in vitro et in vivo. Nous avons etudie certaines proprietes biochimiques de la proteine recombinante. La glycosylation de la proteine est entierement responsable de son heterogeneite. Nous avons produit un an

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50

Aragão, Elisângela Aparecida. "Efeito da suramina na atividade da fosfolipase A2 secretada humana do grupo IIA." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/59/59138/tde-26052009-181259/.

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Abstract:

As fosfolipases A2 (PLA2s, ou fosfatidil-acil hidrolases EC 3.1.1.4) catalisam especificamente a hidrólise das ligações ácido-éster na posição sn-2 de glicerofosfolipídios liberando, como produto da catálise, ácidos graxos e lisofosfolipídio. São encontradas em plantas, mamíferos e em veneno de animais vertebrados e invertebrados e estão envolvidas em uma ampla variedade de processos fisiológicos. A fosfolipase A2 secretada humana do grupo IIA (hsPLA2 gIIA) é uma proteína de fase aguda da resposta imunológica, pois sua expressão é induzida por endotoxinas e citocinas via processos autócrinos

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