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1

Snyder, Jason S. "Questioning human neurogenesis." Nature 555, no. 7696 (2018): 315–16. http://dx.doi.org/10.1038/d41586-018-02629-3.

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2

Murrell, Wayne, Gillian R. Bushell, Jonathon Livesey, et al. "Neurogenesis in adult human." NeuroReport 7, no. 6 (1996): 1189–94. http://dx.doi.org/10.1097/00001756-199604260-00019.

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3

Liu, He, and Ni Song. "Molecular Mechanism of Adult Neurogenesis and its Association with Human Brain Diseases." Journal of Central Nervous System Disease 8 (January 2016): JCNSD.S32204. http://dx.doi.org/10.4137/jcnsd.s32204.

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Recent advances in neuroscience challenge the old dogma that neurogenesis occurs only during embryonic development. Mounting evidence suggests that functional neurogenesis occurs throughout adulthood. This review article discusses molecular factors that affect adult neurogenesis, including morphogens, growth factors, neurotransmitters, transcription factors, and epigenetic factors. Furthermore, we summarize and compare current evidence of associations between adult neurogenesis and human brain diseases such as Alzheimer's disease, Parkinson's disease, Huntington's disease, and brain tumors.
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4

Sugano, Hidenori, Madoka Nakajima, Ikuko Ogino, and Hajime Arai. "Neurogenesis in Human Epileptic Hippocampus." Journal of the Japan Epilepsy Society 26, no. 1 (2008): 16–25. http://dx.doi.org/10.3805/jjes.26.16.

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5

Flor-García, Miguel, Julia Terreros-Roncal, Elena P. Moreno-Jiménez, Jesús Ávila, Alberto Rábano, and María Llorens-Martín. "Unraveling human adult hippocampal neurogenesis." Nature Protocols 15, no. 2 (2020): 668–93. http://dx.doi.org/10.1038/s41596-019-0267-y.

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6

Lucassen, Paul J., Nicolas Toni, Gerd Kempermann, Jonas Frisen, Fred H. Gage, and Dick F. Swaab. "Limits to human neurogenesis—really?" Molecular Psychiatry 25, no. 10 (2019): 2207–9. http://dx.doi.org/10.1038/s41380-018-0337-5.

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7

Inta, agos, and Peter Gass. "Is Forebrain Neurogenesis a Potential Repair Mechanism after Stroke?" Journal of Cerebral Blood Flow & Metabolism 35, no. 7 (2015): 1220–21. http://dx.doi.org/10.1038/jcbfm.2015.95.

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The use of adult subventricular zone (SVZ) neurogenesis as brain repair strategy after stroke represents a hot topic in neurologic research. Recent radiocarbon-14 dating has revealed a lack of poststroke neurogenesis in the adult human neocortex; however, adult neurogenesis has been shown to occur, even under physiologic conditions, in the human striatum. Here, these results are contrasted with experimental poststroke neurogenesis in the murine brain. Both in humans and in rodents, the SVZ generates predominantly calretinin (CR)-expressing GABAergic interneurons, which cannot replace the broad
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8

Kessaris, Nicoletta. "Human cortical interneuron development unraveled." Science 375, no. 6579 (2022): 383–84. http://dx.doi.org/10.1126/science.abn6333.

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9

Mustafin, Rustam N., and Elza K. Khusnutdinova. "Postnatal neurogenesis in the human brain." Morphology 159, no. 2 (2022): 37–46. http://dx.doi.org/10.17816/1026-3543-2021-159-2-37-46.

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Recently, a lot of data has been gathered which demonstrates neurogenesis in the brain of adult humans. In genetics, findings have been obtained that not only prove, but also elucidate the molecular mechanisms of neurogenesis. In some publications, however, morphology disputes neuronal renewal in adulthood. Therefore, this review presents the modern achievements of epigenetics, morphology, and physiology, which confirm and characterize postnatal neurogenesis in detail. We suggest that the introduction of molecular genetic technologies into morphological studies will be the starting point for t
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10

Lewis, Sian. "Human olfaction is not neurogenesis-dependent." Nature Reviews Neuroscience 13, no. 7 (2012): 451. http://dx.doi.org/10.1038/nrn3286.

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11

Eriksson, Peter S., Ekaterina Perfilieva, Thomas Björk-Eriksson, et al. "Neurogenesis in the adult human hippocampus." Nature Medicine 4, no. 11 (1998): 1313–17. http://dx.doi.org/10.1038/3305.

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12

Palmos, Alish B., Rodrigo R. R. Duarte, Demelza M. Smeeth, et al. "Telomere length and human hippocampal neurogenesis." Neuropsychopharmacology 45, no. 13 (2020): 2239–47. http://dx.doi.org/10.1038/s41386-020-00863-w.

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Abstract Short telomere length is a risk factor for age-related disease, but it is also associated with reduced hippocampal volumes, age-related cognitive decline and psychiatric disorder risk. The current study explored whether telomere shortening might have an influence on cognitive function and psychiatric disorder pathophysiology, via its hypothesised effects on adult hippocampal neurogenesis. We modelled telomere shortening in human hippocampal progenitor cells in vitro using a serial passaging protocol that mimics the end-replication problem. Serially passaged progenitors demonstrated sh
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13

Boldrini, Maura, Camille A. Fulmore, Alexandria N. Tartt, et al. "Human Hippocampal Neurogenesis Persists throughout Aging." Cell Stem Cell 22, no. 4 (2018): 589–99. http://dx.doi.org/10.1016/j.stem.2018.03.015.

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14

Valeo, Tom. "Neurogenesis Demonstrated in Human Olfactory Bulb." Neurology Today 7, no. 6 (2007): 34–35. http://dx.doi.org/10.1097/01.nt.0000266435.65543.bc.

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15

Shen, Jianfeng, Lin Xie, XiaoOu Mao, et al. "Neurogenesis after Primary Intracerebral Hemorrhage in Adult Human Brain." Journal of Cerebral Blood Flow & Metabolism 28, no. 8 (2008): 1460–68. http://dx.doi.org/10.1038/jcbfm.2008.37.

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Neurogenesis occurs in discrete regions of normal brains of adult mammals including humans, and is induced in response to brain injury and neurodegenerative disease. Whether intracerebral hemorrhage can also induce neurogenesis in human brain is unknown. Specimens were obtained from patients with primary intracerebral hemorrhage undergoing surgical evacuation of an intracerebral hematoma, and evaluated by two-photon laser scanning confocal microscopy. We found that neural stem/progenitor cell-specific protein markers were expressed in cells located in the perihematomal regions of the basal gan
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16

Estrada-Reyes, Rosa, Daniel B. Quero-Chávez, Salvador Alarcón-Elizalde, et al. "Antidepressant Low Doses of Ketamine and Melatonin in Combination Produce Additive Neurogenesis in Human Olfactory Neuronal Precursors." Molecules 27, no. 17 (2022): 5650. http://dx.doi.org/10.3390/molecules27175650.

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Melatonin (MEL), an indolamine with diverse functions in the brain, has been shown to produce antidepressant-like effects, presumably through stimulating neurogenesis. We recently showed that the combination of MEL with ketamine (KET), an NMDA receptor antagonist, has robust antidepressant-like effects in mice, at doses that, by themselves, are non-effective and have no adverse effects. Here, we show that the KET/MEL combination increases neurogenesis in a clone derived from human olfactory neuronal precursors, a translational pre-clinical model for effects in the human CNS. Neurogenesis was a
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17

Gideon S, Alex, Oke Olanrewaju Oluwaseun, Ekokojide Joy Wilberforce, et al. "Adult Neurogenesis: A Review of Current Perspectives and Implications for Neuroscience Research." Journal of Neuroscience and Neurological Disorders 8, no. 2 (2024): 106–14. http://dx.doi.org/10.29328/journal.jnnd.1001102.

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Background: The study of new neuron formation in the adult brain has sparked controversy and ignited interest among scientists in recent times, these include its occurrence and location in the adult human brain, functional significance, variation in study methods, translation from animal model to human, and ethical challenges involving neural stem cell research. Aim: To provide a comprehensive understanding of adult neurogenesis, functional significance, and challenges and explore the latest advances in the study of adult neurogenesis. Methodology: An extensive and systematic search of electro
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18

Coplan, Jeremy D., Shariful Syed, Tarique D. Perera, et al. "Glucagon-Like Peptide-1 as Predictor of Body Mass Index and Dentate Gyrus Neurogenesis: Neuroplasticity and the Metabolic Milieu." Neural Plasticity 2014 (2014): 1–10. http://dx.doi.org/10.1155/2014/917981.

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Glucagon-like peptide-1 (GLP-1) regulates carbohydrate metabolism and promotes neurogenesis. We reported an inverse correlation between adult body mass and neurogenesis in nonhuman primates. Here we examine relationships between physiological levels of the neurotrophic incretin, plasma GLP-1 (pGLP-1), and body mass index (BMI) in adolescence to adult neurogenesis and associations with a diabesity diathesis and infant stress. Morphometry, fasting pGLP-1, insulin resistance, and lipid profiles were measured in early adolescence in 10 stressed and 4 unstressed male bonnet macaques. As adults, den
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19

Stępień, Tomasz, Sylwia Tarka, Natalia Chmura, et al. "Influence of SARS-CoV-2 on Adult Human Neurogenesis." Cells 12, no. 2 (2023): 244. http://dx.doi.org/10.3390/cells12020244.

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Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is associated with the onset of neurological and psychiatric symptoms during and after the acute phase of illness. Inflammation and hypoxia induced by SARS-CoV-2 affect brain regions essential for fine motor function, learning, memory, and emotional responses. The mechanisms of these central nervous system symptoms remain largely unknown. While looking for the causes of neurological deficits, we conducted a study on how SARS-CoV-2 affects neurogenesis. In this study, we compared a control group with a group of patients
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20

Yau, Suk-yu, Joana Gil-Mohapel, Brian R. Christie, and Kwok-fai So. "Physical Exercise-Induced Adult Neurogenesis: A Good Strategy to Prevent Cognitive Decline in Neurodegenerative Diseases?" BioMed Research International 2014 (2014): 1–20. http://dx.doi.org/10.1155/2014/403120.

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Cumulative evidence has indicated that there is an important role for adult hippocampal neurogenesis in cognitive function. With the increasing prevalence of cognitive decline associated with neurodegenerative diseases among the ageing population, physical exercise, a potent enhancer of adult hippocampal neurogenesis, has emerged as a potential preventative strategy/treatment to reduce cognitive decline. Here we review the functional role of adult hippocampal neurogenesis in learning and memory, and how this form of structural plasticity is altered in neurodegenerative diseases known to involv
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21

González-Martínez, Jorge A., William E. Bingaman, Steven A. Toms, and Imad M. Najm. "Neurogenesis in the postnatal human epileptic brain." Journal of Neurosurgery 107, no. 3 (2007): 628–35. http://dx.doi.org/10.3171/jns-07/09/0628.

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Object The normal adult human telencephalon does not reveal evidence of spontaneous neuronal migration and differentiation despite the robust germinal capacity of the subventricular zone (SVZ) astrocyte ribbon that contains neural stem cells. This might be because it is averse to accepting new neurons into an established neuronal network, probably representing an evolutionary acquisition to prevent the formation of anomalous neuronal circuits. Some forms of epilepsy, such as malformations of cortical development, are thought to be due to abnormal corticogenesis during the embryonic and early p
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22

Gulati, Anil. "Understanding neurogenesis in the adult human brain." Indian Journal of Pharmacology 47, no. 6 (2015): 583. http://dx.doi.org/10.4103/0253-7613.169598.

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23

Keenan, Thomas M., Aaron D. Nelson, Jeffrey R. Grinager, Jarett C. Thelen, and Clive N. Svendsen. "Real Time Imaging of Human Progenitor Neurogenesis." PLoS ONE 5, no. 10 (2010): e13187. http://dx.doi.org/10.1371/journal.pone.0013187.

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24

Lee, Hyunah, and Sandrine Thuret. "Adult Human Hippocampal Neurogenesis: Controversy and Evidence." Trends in Molecular Medicine 24, no. 6 (2018): 521–22. http://dx.doi.org/10.1016/j.molmed.2018.04.002.

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25

Gandhi, Sonu, Jalaj Gupta, and Prem Prakash Tripathi. "The Curious Case of Human Hippocampal Neurogenesis." ACS Chemical Neuroscience 10, no. 3 (2019): 1131–32. http://dx.doi.org/10.1021/acschemneuro.9b00063.

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26

Gonzalez-Martinez, Jorge A., Gabriel Moddel, Imad M. Najm, Hans O. Lüders, and William E. Bingaman. "712 Neurogenesis in Adult Human Neocortical Epilepsy." Neurosurgery 55, no. 2 (2004): 456. http://dx.doi.org/10.1227/00006123-200408000-00048.

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27

Kempermann, Gerd, Fred H. Gage, Ludwig Aigner, et al. "Human Adult Neurogenesis: Evidence and Remaining Questions." Cell Stem Cell 23, no. 1 (2018): 25–30. http://dx.doi.org/10.1016/j.stem.2018.04.004.

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28

Berry, M. "Neurogenesis and gliogenesis in the human brain." Food and Chemical Toxicology 24, no. 2 (1986): 79–89. http://dx.doi.org/10.1016/0278-6915(86)90341-8.

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29

Winner, Beate, D. Chichung Lie, Edward Rockenstein та ін. "Human Wild-Type α-Synuclein Impairs Neurogenesis". Journal of Neuropathology & Experimental Neurology 63, № 11 (2004): 1155–66. http://dx.doi.org/10.1093/jnen/63.11.1155.

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30

Kheirbek, Mazen A., and René Hen. "(Radio)active Neurogenesis in the Human Hippocampus." Cell 153, no. 6 (2013): 1183–84. http://dx.doi.org/10.1016/j.cell.2013.05.033.

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31

Fan, Xiaoying, Yuanyuan Fu, Xin Zhou, et al. "Single-cell transcriptome analysis reveals cell lineage specification in temporal-spatial patterns in human cortical development." Science Advances 6, no. 34 (2020): eaaz2978. http://dx.doi.org/10.1126/sciadv.aaz2978.

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Neurogenesis processes differ in different areas of the cortex in many species, including humans. Here, we performed single-cell transcriptome profiling of the four cortical lobes and pons during human embryonic and fetal development. We identified distinct subtypes of neural progenitor cells (NPCs) and their molecular signatures, including a group of previously unidentified transient NPCs. We specified the neurogenesis path and molecular regulations of the human deep-layer, upper-layer, and mature neurons. Neurons showed clear spatial and temporal distinctions, while glial cells of different
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32

Gage, Fred H. "Adult neurogenesis in neurological diseases." Science 374, no. 6571 (2021): 1049–50. http://dx.doi.org/10.1126/science.abm7468.

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33

Niklison-Chirou, Maria Victoria, Massimiliano Agostini, Ivano Amelio, and Gerry Melino. "Regulation of Adult Neurogenesis in Mammalian Brain." International Journal of Molecular Sciences 21, no. 14 (2020): 4869. http://dx.doi.org/10.3390/ijms21144869.

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Adult neurogenesis is a multistage process by which neurons are generated and integrated into existing neuronal circuits. In the adult brain, neurogenesis is mainly localized in two specialized niches, the subgranular zone (SGZ) of the dentate gyrus and the subventricular zone (SVZ) adjacent to the lateral ventricles. Neurogenesis plays a fundamental role in postnatal brain, where it is required for neuronal plasticity. Moreover, perturbation of adult neurogenesis contributes to several human diseases, including cognitive impairment and neurodegenerative diseases. The interplay between extrins
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34

Yuan, Ti-Fei, Jiang Li, Fei Ding, and Oscar Arias-Carrion. "Evidence of adult neurogenesis in non-human primates and human." Cell and Tissue Research 358, no. 1 (2014): 17–23. http://dx.doi.org/10.1007/s00441-014-1980-z.

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35

Seonwoo, Hoon, Kyung-Je Jang, Dohyeon Lee, et al. "Neurogenic Differentiation of Human Dental Pulp Stem Cells on Graphene-Polycaprolactone Hybrid Nanofibers." Nanomaterials 8, no. 7 (2018): 554. http://dx.doi.org/10.3390/nano8070554.

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Stem cells derived from dental tissues—dental stem cells—are favored due to their easy acquisition. Among them, dental pulp stem cells (DPSCs) extracted from the dental pulp have many advantages, such as high proliferation and a highly purified population. Although their ability for neurogenic differentiation has been highlighted and neurogenic differentiation using electrospun nanofibers (NFs) has been performed, graphene-incorporated NFs have never been applied for DPSC neurogenic differentiation. Here, reduced graphene oxide (RGO)-polycaprolactone (PCL) hybrid electrospun NFs were developed
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36

Dumitru, Ionut, Marta Paterlini, Margherita Zamboni, et al. "Identification of proliferating neural progenitors in the adult human hippocampus." Science 389, no. 6755 (2025): 58–63. https://doi.org/10.1126/science.adu9575.

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Continuous adult hippocampal neurogenesis is involved in memory formation and mood regulation but is challenging to study in humans. Difficulties finding proliferating progenitor cells called into question whether and how new neurons may be generated. We analyzed the human hippocampus from birth through adulthood by single-nucleus RNA sequencing. We identified all neural progenitor cell stages in early childhood. In adults, using antibodies against the proliferation marker Ki67 and machine learning algorithms, we found proliferating neural progenitor cells. Furthermore, transcriptomic data sho
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37

Kim, Curie, Ana Margarida Pinto, Claire Bordoli, et al. "Energy Restriction Enhances Adult Hippocampal Neurogenesis-Associated Memory after Four Weeks in an Adult Human Population with Central Obesity; a Randomized Controlled Trial." Nutrients 12, no. 3 (2020): 638. http://dx.doi.org/10.3390/nu12030638.

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Adult neurogenesis, the generation of new neurons throughout life, occurs in the subventricular zone of the dentate gyrus in the human hippocampal formation. It has been shown in rodents that adult hippocampal neurogenesis is needed for pattern separation, the ability to differentially encode small changes derived from similar inputs, and recognition memory, as well as the ability to recognize previously encountered stimuli. Improved hippocampus-dependent cognition and cellular readouts of adult hippocampal neurogenesis have been reported in daily energy restricted and intermittent fasting adu
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38

Xu, Pei, Junling Gao, Chao Shan, et al. "Inhibition of innate immune response ameliorates Zika virus-induced neurogenesis deficit in human neural stem cells." PLOS Neglected Tropical Diseases 15, no. 3 (2021): e0009183. http://dx.doi.org/10.1371/journal.pntd.0009183.

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Global Zika virus (ZIKV) outbreaks and their strong link to microcephaly have raised major public health concerns. ZIKV has been reported to affect the innate immune responses in neural stem/progenitor cells (NS/PCs). However, it is unclear how these immune factors affect neurogenesis. In this study, we used Asian-American lineage ZIKV strain PRVABC59 to infect primary human NS/PCs originally derived from fetal brains. We found that ZIKV overactivated key molecules in the innate immune pathways to impair neurogenesis in a cell stage-dependent manner. Inhibiting the overactivated innate immune
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39

Gil, Laura, Erika Chi-Ahumada, Sandra A. Niño, et al. "Pathological Nuclear Hallmarks in Dentate Granule Cells of Alzheimer’s Patients: A Biphasic Regulation of Neurogenesis." International Journal of Molecular Sciences 23, no. 21 (2022): 12873. http://dx.doi.org/10.3390/ijms232112873.

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The dentate gyrus (DG) of the human hippocampus is a complex and dynamic structure harboring mature and immature granular neurons in diverse proliferative states. While most mammals show persistent neurogenesis through adulthood, human neurogenesis is still under debate. We found nuclear alterations in granular cells in autopsied human brains, detected by immunohistochemistry. These alterations differ from those reported in pyramidal neurons of the hippocampal circuit. Aging and early AD chromatin were clearly differentiated by the increased epigenetic markers H3K9me3 (heterochromatin suppress
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40

Scordel, Chloé, Alexandra Huttin, Marielle Cochet-Bernoin, et al. "Borna Disease Virus Phosphoprotein Impairs the Developmental Program Controlling Neurogenesis and Reduces Human GABAergic Neurogenesis." PLOS Pathogens 11, no. 4 (2015): e1004859. http://dx.doi.org/10.1371/journal.ppat.1004859.

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41

Farioli-Vecchioli, Stefano, Valentina Ricci, and Silvia Middei. "Adult Hippocampal Neurogenesis in Alzheimer’s Disease: An Overview of Human and Animal Studies with Implications for Therapeutic Perspectives Aimed at Memory Recovery." Neural Plasticity 2022 (January 15, 2022): 1–18. http://dx.doi.org/10.1155/2022/9959044.

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The mammalian hippocampal dentate gyrus is a niche for adult neurogenesis from neural stem cells. Newborn neurons integrate into existing neuronal networks, where they play a key role in hippocampal functions, including learning and memory. In the ageing brain, neurogenic capability progressively declines while in parallel increases the risk for developing Alzheimer’s disease (AD), the main neurodegenerative disorder associated with memory loss. Numerous studies have investigated whether impaired adult neurogenesis contributes to memory decline in AD. Here, we review the literature on adult hi
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42

Nano, Patricia R., and Aparna Bhaduri. "Mounting evidence suggests human adult neurogenesis is unlikely." Neuron 110, no. 3 (2022): 353–55. http://dx.doi.org/10.1016/j.neuron.2022.01.004.

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43

Bueno, Carlos, and Salvador Martínez. "Neurogenesis similarities in different human adult stem cells." Neural Regeneration Research 16, no. 1 (2021): 123. http://dx.doi.org/10.4103/1673-5374.286967.

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44

Danzer, Steve C. "Adult Neurogenesis in the Human Brain: Paradise Lost?" Epilepsy Currents 18, no. 5 (2018): 329–31. http://dx.doi.org/10.5698/1535-7597.18.5.329.

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45

Kallur, Therése, Ramiro Gisler, Olle Lindvall, and Zaal Kokaia. "Pax6 promotes neurogenesis in human neural stem cells." Molecular and Cellular Neuroscience 38, no. 4 (2008): 616–28. http://dx.doi.org/10.1016/j.mcn.2008.05.010.

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46

Nogueira, A., and M. Teixeira. "Adult human neurogenesis: Less limited than previously thought." Journal of the Neurological Sciences 381 (October 2017): 347–48. http://dx.doi.org/10.1016/j.jns.2017.08.987.

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47

Paredes, Mercedes F., Shawn F. Sorrells, Arantxa Cebrian-Silla, et al. "Does Adult Neurogenesis Persist in the Human Hippocampus?" Cell Stem Cell 23, no. 6 (2018): 780–81. http://dx.doi.org/10.1016/j.stem.2018.11.006.

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48

Yu, Diana Xuan, Francesco Paolo Di Giorgio, Jun Yao, et al. "Modeling Hippocampal Neurogenesis Using Human Pluripotent Stem Cells." Stem Cell Reports 2, no. 3 (2014): 295–310. http://dx.doi.org/10.1016/j.stemcr.2014.01.009.

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49

Yu, Diana Xuan, Francesco Paolo Di Giorgio, Jun Yao, et al. "Modeling Hippocampal Neurogenesis Using Human Pluripotent Stem Cells." Stem Cell Reports 3, no. 1 (2014): 217. http://dx.doi.org/10.1016/j.stemcr.2014.06.015.

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50

Murrell, W., G. Bushell, J. McGrath, P. Bates, and A. Mackay-Sim. "Neurogenesis in vitro of adult human olfactory epithelium." Schizophrenia Research 18, no. 2-3 (1996): 178–79. http://dx.doi.org/10.1016/0920-9964(96)85563-0.

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