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Dissertations / Theses on the topic 'Human ovarian carcinoma cells'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Chu, Stephanie Wai Ling Clinical School St George Hospital Faculty of Medicine UNSW. "An investigation into the effects of albendazole on human ovarian carcinoma cells." Awarded by:University of New South Wales. Clinical School - St George Hospital, 2007. http://handle.unsw.edu.au/1959.4/40448.

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Paclitaxel (PTX) is an effective anti-mitotic drug. It stops cancer from spreading by interfering with the microtubule dynamics which in turn leads to cell cycle arrest and eventually cell death. Despite the clinical success in treating different types of cancers, resistance to PTX remains a major hurdle for successful treatment in relapse patients. Albendazole (ABZ) is a popular anthelmintic used world-wide for the treatment of various types of helmintic infections. In helminthes, ABZ binds to ??-tubulin and inhibits microtubule polymerisation. It was subsequently found that ABZ has anti-canc

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2

Vasey, Paul A. "In vitro studies of p53 and cisplatin-resistance in human ovarian carcinoma cells." Thesis, University of Glasgow, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.387507.

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3

Virtanen, Siru Sirkku Pauliina. "Phenotypic and functional characterisation of cancer stem cells in human high-grade serous ovarian carcinoma." Thesis, University of Cambridge, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648879.

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4

Abbott, Heather Elizabeth. "Comparisons of the factors influencing intrinsic radiosensitivity between two isogenic human ovarian carcinoma cell lines." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0021/MQ57080.pdf.

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5

Illuzzi, G. "SPHINGOLIPID METABOLISM'S ALTERATIONS CORRELATED WITH TUMOR CELL INVASIVITY AND FENRETINIDE RESISTANCE IN A HUMAN OVARIAN CARCINOMA CELL LINE." Doctoral thesis, Università degli Studi di Milano, 2010. http://hdl.handle.net/2434/160742.

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Glycosphingolipids (GSL) modulate several signal transduction processes controlling cell proliferation, survival, differentiation and transformation. Alterations in the expression of carbohydrate epitopes associated with GSL are frequent in tumors, and it has been hypothesized that GSL could play important roles in modulating some of the properties of tumor cells. The contribution of transformation-associated changes in GSL composition to the tumor phenotype are very complex and not fully elucidated, and likely implies heterogeneous molecular mechanisms. However, at least two well established

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6

Joun, George Louis. "Dissecting the Cellular and Molecular Regulation of Chemo-Resistance and Epithelial to Mesenchymal Transition in Human Ovarian Carcinoma." Thesis, The University of Sydney, 2021. https://hdl.handle.net/2123/28748.

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Ovarian carcinoma is the malignant transformation of ovarian or fallopian tube epithelial cells. High-grade serous carcinoma (HGSOC) diagnosis carries a 30% 5-year survival. The development of chemotherapy resistance is common leading to relapse of a resistant tumour. Due to inherent genetic/chromosomal instability in HGSOC, these tumours are multi-clonal leading to treatment resistance and metastasis. It was aimed to understand the clonal heterogeneity in HGSOC cell lines through single cell molecular and physiological dissection. Chapter 3 describes the use of single cell derived strains, si

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7

Whitfield, Fatima. "Gamma-Delta T-Cells in Patients with Ovarian Carcinoma." Diss., Temple University Libraries, 2008. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/3422.

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Microbiology and Immunology<br>Ph.D.<br>Ovarian cancer is the fifth most common cause of death from all cancers among women in the Western world and the most lethal of all gynecological cancers. The epithelial ovarian carcinomas (EOC) represent approximately 90% of all human ovarian malignant neoplasm. The five-year survival rate for patients with EOC is attributed to late diagnosis and poor response to therapy. T-cells play an important role in tumor immunity of EOC, evidence includes infiltrating CD3+ T-cells in EOC lesions and a specific antigen driven immune response. Human gd TCR + T-cell

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8

Al-Azraqi, Abdulla Ali. "The P53 tumour suppressor pathway in human ovarian carcinoma." Thesis, University of Newcastle Upon Tyne, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.264421.

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9

Buckle, Clive. "Production of human monoclonal antibodies to ovarian carcinoma using phage display." Thesis, University of Sheffield, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.541444.

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10

Touboul, Cyril. "Influence du stroma et des cellules souches mésenchymateuses sur la dissémination et la résistance au traitement des carcinomes ovariens épithéliaux." Phd thesis, Université Paris Sud - Paris XI, 2012. http://tel.archives-ouvertes.fr/tel-00907889.

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Le cancer épithélial de l'ovaire (EOC) a la particularité d'être diagnostiqué à un stade avancé chez 75% des patientes et de récidiver dans un grand nombre de cas malgré une bonne réponse initiale à la chimiothérapie, expliquant ainsi son pronostic sombre. Le rôle du microenvironnement tumoral semble être de premier plan dans le développement et la survie des cellules cancéreuses mais il existe encore peu de données concernant les cellules mésenchymateuses souches (MSC). Dans ce travail nous avons donc cherché à déterminer les mécanismes moléculaires entre les MSC et les cellules tumorales ova

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11

Escrevente, Cristina. "Protein glycosylation of exosomes from ovarian carcinoma cells: structures and biological roles." Doctoral thesis, Universidade Nova de Lisboa. Instituto de Tecnologia Química e Biológica, 2011. http://hdl.handle.net/10362/6864.

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Dissertation presented to obtain the Ph.D. degree in Biology<br>Exosomes are small membrane vesicles that are secreted by several cell types including tumour cells. They are formed intracellularly by an inward budding of the membrane of endosomal compartments which are converted to multivesicular bodies. Exosomes are then released into the extracellular environment after fusion of the multivesicular bodies with the plasma membrane. Upon internalization by other cells they may transfer proteins and RNA among cells. Tumour-derived exosomes can promote angiogenesis, cell proliferation, tum

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12

Harkin, Denis Paul. "Studies of chromosome 17 in human ovarian cancer cells." Thesis, Queen's University Belfast, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.238972.

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13

Huang, Xiufeng [Verfasser]. "Short Tandem Repeat Profiles In Ovarian Carcinoma Cells During Primary Culture / Xiufeng Huang." Kiel : Universitätsbibliothek Kiel, 2019. http://d-nb.info/1198210575/34.

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14

Radu, Maria. "The role of p27 phosphorylation in mediating atRA sensitivity of ovarian carcinoma cells." Diss., Temple University Libraries, 2008. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/5459.

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Microbiology and Immunology<br>Ph.D.;<br>All trans retinoic acid (atRA) has been shown to inhibit the growth of CAOV3 ovarian carcinoma cells. This results from arrest of the cell cycle during the G1 phase. G1 checkpoint is regulated by a multitude of molecules, including the retinoblastoma family of proteins, cyclin dependent kinases (Cdks), and cyclin dependent kinase inhibitors. P27, a cyclin dependent kinase inhibitor regulating G1 checkpoint has been shown to have elevated levels in response to atRA treatment. In these studies we investigated the role of p27 phosphorylation in mediating a

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15

Fischer, Oliver Martin. "Receptor Tyrosine Kinase Activation in Human Carcinoma Cells." Diss., lmu, 2004. http://nbn-resolving.de/urn:nbn:de:bvb:19-17997.

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16

Pan, Chendong. "Neural differentiation from human embryonal carcinoma stem cells." Thesis, Durham University, 2007. http://etheses.dur.ac.uk/2460/.

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It is understood that retinoic acid (RA), sonic hedgehog (Shh) and bone morphogenic proteins (BMPs) play an important role in cell fate determination and the specification of inter-neurons and motor neurons along the dorsal-ventral axis in the neural tube. In this study, we investigated the function of these signalling molecules to instruct the differentiation of human pluripotent stem cells to form specific neuronal subtypes. TERA2.cl.SP12 embryonal carcinoma (EC) cells are a robust caricature of human embryogenesis and an accepted model of neural differentiation. Gene and protein expression

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17

Qualtrough, John David. "Bone morphogenetic proteins in human embryonal carcinoma cells." Thesis, University of Sheffield, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.311810.

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18

Ratcliffe, Kirsty Elizabeth. "The isolation and culture of human ovarian microvascular endothelial cells." Thesis, University of Southampton, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.302026.

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19

溫錫剛 and Shek-kong Thomas Wan. "Establishment and characterization of human ovarian surface epithelialcells immortalized by human papilloma viral oncogenes." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1997. http://hub.hku.hk/bib/B31236236.

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20

OYESANYA, REGINA. "MOLECULAR MECHANISMS FOR REGULATION OF GENE EXPRESSION BY LYSOPHOSPHATIDIC ACID IN OVARIAN CARCINOMA CELLS." VCU Scholars Compass, 2009. http://scholarscompass.vcu.edu/etd/1689.

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Lysophosphatidic acid (LPA) is a potent bioactive phospholipid mediator that functions through multiple G protein couple receptors (GPCRs). LPA is elevated in ascites of ovarian cancer patients and is involved in growth, survival and metastasis of ovarian cancer cells. Gene promoter analyses revealed that some LPA-target genes share similar sets of binding sites for prominent transcription factors posing the possibility of a general mechanism for activation of their expression by LPA. Detailed investigation of the mechanisms of regulation of cyclooxygenase 2 (Cox-2), a paradigm of LPA-regulate

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21

Wan, Shek-kong Thomas. "Establishment and characterization of human ovarian surface epithelial cells immortalized by human papilloma viral oncogenes /." Hong Kong : University of Hong Kong, 1997. http://sunzi.lib.hku.hk/hkuto/record.jsp?B18656456.

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22

Jung, Marc [Verfasser]. "OCT4 regulated transcription networks in human embryonic stem cells and human embryonal carcinoma cells / Marc Jung." Berlin : Freie Universität Berlin, 2009. http://d-nb.info/1023957345/34.

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23

Drake, Jeremy. "The expression and function of secreted frizzled-related protein 4 in human serous ovarian carcinoma." University of Western Australia. School of Anatomy and Human Biology, 2007. http://theses.library.uwa.edu.au/adt-WU2007.0072.

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[Truncated abstract] Ovarian cancer is currently the leading cause of death from gynaecological malignancies in women from developed countries. Serous ovarian cancer is the most prevalent type of all ovarian cancers, with the majority diagnosed in an advanced stage where treatment efficacy is reduced and patient survival is poor. Because of this fact, the development of improved detection and treatment strategies are necessary, with much research focussing on the complex molecular pathways involved in ovarian tumour growth as one potential avenue for intervention. Apoptosis, or programmed cell

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Drake, Jeremy. "The expression and function of secreted frizzled-related protein 4 in human serous ovarian carcinoma /." Connect to this title, 2006. http://theses.library.uwa.edu.au/adt-WU2007.0072.

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25

Reed, Stephanie M. "Analyzing GFP-tagged cytoskeletal protein colocalization in human carcinoma cells." Thesis, Massachusetts Institute of Technology, 2007. http://hdl.handle.net/1721.1/40477.

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Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2007.<br>Includes bibliographical references.<br>Cytoskeletal proteins function as dynamic, complex components involved in cellular structure and signaling. Characterizing the roles of such proteins would greatly benefit many research areas, including the study of cancer and protein-related diseases. There is currently no accurate, high throughput method of image analysis that clearly describes protein behavior within the cell. In addressing this problem, we chose to characterize proteins based on the coloca

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26

Culak, Renata A. "Characterisation of selected sialoglycoproteins isolated from human lung carcinoma cells." Thesis, University of East London, 2001. http://roar.uel.ac.uk/3572/.

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Carbohydrate moieties on the cell surface play an important role in cellular recognition. Increased sialylation of cell surface glycoproteins has been reported in malignant tumours and has been correlated with the invasive and metastatic potential of the cells. The aim of this work was to investigate the expression of cell membrane glycoproteins on four lung cancer cell lines and to identify potential changes in their sialylation employing the tools of proteomics and functional genomics. Three highly metastatic cell lines: PC 14- human lung adenocarcinoma, PLC- primary liver carcinoma and T24-

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27

Slaibi, Jinani Elias. "Targets of Hsa-miR-488* In Human Prostate Carcinoma Cells." Cleveland State University / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=csu1273843449.

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28

Chung, Chin-man. "Involvement of chromosome 20q in the immortalization of human ovarian surface epithelial cells." Click to view the E-thesis via HKUTO, 2004. http://sunzi.lib.hku.hk/hkuto/record/B31971672.

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29

Chung, Chin-man, and 鍾展雯. "Involvement of chromosome 20q in the immortalization of human ovarian surface epithelial cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B31971672.

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30

Wiles, M. V. "The use of embryonal carcinoma cells to study early human development." Thesis, Open University, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.383735.

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31

Jones, Elizabeth Louise. "Characterization of IL-1-stimulated phosphorylation in human epidermal carcinoma cells." Thesis, Open University, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.357978.

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32

McBeth, Lucien Reiter. "Glucocorticoid Receptor beta Increases the Migration of Human Urothelial Carcinoma Cells." University of Toledo Health Science Campus / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=mco1467031531.

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33

Finkernagel, Florian [Verfasser], and Rolf [Akademischer Betreuer] Müller. "On the transcriptome of ovarian carcinoma and immune cells found in ascites / Florian Finkernagel ; Betreuer: Rolf Müller." Marburg : Philipps-Universität Marburg, 2017. http://d-nb.info/1149544414/34.

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34

Papacleovoulou, Georgia. "Steroid signalling in the human ovarian surface epithelium wound healing." Thesis, University of Edinburgh, 2009. http://hdl.handle.net/1842/4237.

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The human ovarian surface epithelium (hOSE) is a cell monolayer that covers the surface of the ovary. Natural events like incessant ovulation, associated reproductive hormone action prior to and post-ovulation, along with the ovulationassociated inflammation, that result in injury and repair of hOSE, are considered to have a role in the development of epithelial ovarian cancer (EOC). Progesterone is apoptotic and anti-inflammatory, whereas androgens appear cytoproliferative for hOSE. Local generation of these steroid hormones is subject to 3β-hydroxysteroid dehydrogenase (3β-HSD) activity. Mor

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35

Glinghammar, Björn. "Toxicological aspects of bile acids and human fecal water on cultered human colon carcinoma cells /." Stockholm, 2001. http://diss.kib.ki.se/2001/91-628-4816-x/.

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36

Xie, X. "GANGLIOSIDE-DEPENDENT MEMBRANE ORGANIZATION CONTROLLING THE ADHESION AND MOTILITY OF HUMAN OVARIAN CANCER CELLS." Doctoral thesis, Università degli Studi di Milano, 2014. http://hdl.handle.net/2434/246740.

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Glycosphingolipids, due to their tendency to form laterally separated liquid-ordered phases, possess a high potential for the creation of order in biological membranes. The formation of glycosphingolipid-rich membrane domains within the membrane has profound consequences on the membrane organization at different levels, and on the conformational and biological properties of membrane-associated proteins and multimolecular protein complexes (1). Glycosphingolipids modulate several signal transduction processes controlling cell proliferation, survival, differentiation, and transformation. Since

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37

Lundin, Desiré. "Do the new signal transduction modulators have activity in vitro in tumor cells from ovarian carcinoma and lymphoma?" Thesis, Uppsala University, Department of Medical Biochemistry and Microbiology, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6158.

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<p>During the last decades, chemotherapy with cytotoxic drugs has played a significant role in cancer therapy. It’s important to develop new anticancer drugs, and drug sensitivity testing in vitro can be used to find the right diagnosis for the newly developed substances.</p><p>The aim of this study was to investigate the cytotoxic activity of the new signal transduction modulators bortezomib, gefitinib and PKC412. The well-established substances cisplatin, cytarabine, doxorubicin and vincristin were investigated for comparison.</p><p>The activity of the cytotoxic drugs was analysed in human t

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38

張子臣 and Zichen Zhang. "Anticancer effects of hexamethylene bisacetamide on human colon carcinoma cells in vitro." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1999. http://hub.hku.hk/bib/B31239766.

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39

Zhang, Zichen. "Anticancer effects of hexamethylene bisacetamide on human colon carcinoma cells in vitro /." Hong Kong : University of Hong Kong, 1999. http://sunzi.lib.hku.hk/hkuto/record.jsp?B21021065.

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40

Asante, Du-Bois. "Development and evaluation of methodologies for analysis of CTC and ctDNA in patients with ovarian carcinoma." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2022. https://ro.ecu.edu.au/theses/2570.

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About 70% of patients with ovarian cancer (OC) are diagnosed at an advanced stage (III-IV), with associated poor prognosis, even after chemotherapeutic interventions (mostly platinum taxane-based), leading to poor survival rates. The current biomarkers available in the clinic are not enough for efficient prognostication and surveillance of OC. Hence, more accurate and reliable biomarkers of patient disease status are urgently required. Currently, histopathological evaluation of tumour biopsies is the gold standard in clinical practice with the purpose of evaluating specific biomarkers to predi

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41

Wagner, Steve [Verfasser], and Andreas [Akademischer Betreuer] Trumpp. "Identification of Tumor Initiating Cells in a Patient-Matched Model of Serous Ovarian Carcinoma / Steve Wagner ; Betreuer: Andreas Trumpp." Heidelberg : Universitätsbibliothek Heidelberg, 2013. http://d-nb.info/1177382660/34.

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42

Marfels, Christian. "Characterization of in vivo chemoresistant human hepatocellular carcinoma cells with transendothelial differentiation capacities." Diss., Ludwig-Maximilians-Universität München, 2015. http://nbn-resolving.de/urn:nbn:de:bvb:19-181890.

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Chemotherapeutic treatment of hepatocellular carcinoma often leads to chemoresistance during therapy or upon relapse of tumors. For the development of better treatments, a better understanding of biochemical changes in the resistant tumors is needed. Therefore, especially in vivo models are very important tools to generate standardized cell-material, which can be examined by high throughput techniques. Thus, it should be possible to find new targets for therapy or even for diagnostic. This thesis focusses on the characterization of the in vivo chemoresistant human hepatocellular carcinoma HUH-

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43

Chen, Yen-Jung, and 陳彥蓉. "Enhancement of radiation response by K1 in human ovarian carcinoma SKOV-3 cells." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/e7q7mx.

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碩士<br>中國醫藥大學<br>藥物化學研究所<br>96<br>2-(2-Fluorophenyl)-6,7-methylenedioxy-4-quinolone (K1), a synthetic 2-phenyl-4-quinolone analog, was identified as a potent and selective antitumor agent in several human cancer cells, including breast cancer and ovarian cancer. The present study investigated the in vitro radiosensitizing effect of K1 and the underlying molecular mechanisms. K1 induced growth inhibition of ovarian cancer SKOV-3 cells and breast cancer MCF-7 and MDA-MB-231 cells in a concentration-dependent manner without overtly impairing the viability of normal cells (PBMC) obviously and enhan

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Huei-yi, Lai, and 賴慧宜. "Inhibition of cell motility by troglitazone in human ovarian carcinoma cell line." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/29631525678668452321.

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碩士<br>國防醫學院<br>微生物及免疫學研究所<br>95<br>Abstract Troglitazone (TGZ) is a peroxisome proliferator-activated receptor gamma (PPARg) agonist and a potential anticancer agent (inducer of mitotic arrest and apoptosis in cancer cells). Little is known about the effect of this agent on cancer cell migration. The present study aims to clarify the effect of TGZ on cell motility in a human ovarian carcinoma cell line, ES-2. We demonstrated that TGZ dose- and time-dependently impairs cell migration as assessed by wound-healing and Boyden chamber transwell experiments. TGZ treatment impaired several proce

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Chen, Chun-Ko, and 陳俊各. "Effect of Daidzein in HER2 over-expressing human ovarian carcinoma SKOV3 cell." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/24115349465152916486.

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碩士<br>淡江大學<br>生命科學研究所碩士班<br>97<br>In the past study, daidzein, one isoflavone in Kudzu, could repress proliferation of colon, cervical, pancreatic and breast cancer cells. Human Epidermal Growth Factor 2 protein (HER2) , p185HER2/neu is over-expressed in sveral cancers. This study found that daidzein could not only inhibit cell proliferation of p185HER2/neu over-expressing ovarian carcinoma SKOV3 cells, but also repress p185HER2/neu protein expression. In the current study found daidzein suppresses the HER2 oncogene expression at the transcriptional level. In addition, this study also found th

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Pantshwa, Jonathan Monwabisi. "Implantable antineoplastic-loaded antibody functionalized nanomicelles for human ovarian carcinoma cell targeting by molecular and in vivo investigations." Thesis, 2017. https://hdl.handle.net/10539/25525.

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A thesis submitted to the Faculty of Health Sciences, University of the Witwatersrand, in fulfillment of the requirements for the degree of Doctor of Philosophy. Johannesburg, 2017.<br>Epithelial ovarian cancer (EOC) is the most insidious, fatal gynaecological malignancy that accounts for millions of deaths in female population. Globally, the five-year survival period is between 15–20% for patience with clinical late stage ovarian malignancy in spite of surgery and platinum treatment. This study aimed to design and develop a novel drug delivery system employing antibody-ligand functionalize

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LIN, JUN-MAO, and 林俊茂. "Isolation and characterization of human ovarian carcinoma A2780 cell resistant to VM-26, a topoisomerase II-targeting drug." Thesis, 1991. http://ndltd.ncl.edu.tw/handle/65550258170309238664.

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Shi, Xuan Cheng, and 施旋呈. "Studying of down regulation of K19 expression in human ovarian teratoma transformed squamous cell carcinoma, C9 mediated by oxygen depletion." Thesis, 1996. http://ndltd.ncl.edu.tw/handle/03084450528244279921.

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49

Gomes, Joana Raquel Afonso. "Protein glycosylation of extracellular vesicles from ovarian carcinoma cells." Master's thesis, 2015. http://hdl.handle.net/10362/43582.

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Extracellular vesicles (EVs) are released by almost all types of cells, including tumor, immune and stem cells, and are also present in body fluids like saliva, urine, breast milk and malignant ascites. EVs have a unique cargo of proteins, lipids and nucleic acids, and conserve characteristics from donor cells.

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YANG, WEN-QIN, and 楊文琴. "Gene expression of ovarian carcinoma cells during sodium butyrate induced differentiation." Thesis, 1991. http://ndltd.ncl.edu.tw/handle/12848558662587543644.

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