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Journal articles on the topic 'Human ovarian carcinoma cells'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Wu, Guang-Jer. "METCAM/MUC18 Decreases the Malignant Propensity of Human Ovarian Carcinoma Cells." International Journal of Molecular Sciences 19, no. 10 (2018): 2976. http://dx.doi.org/10.3390/ijms19102976.

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METCAM/MUC18 is an integral membrane cell adhesion molecule (CAM) in the Ig-like gene super-family. It can carry out common functions of CAMs which is to perform intercellular interactions and interaction of cell with extracellular matrix in tumor microenvironment, to interact with various signaling pathways and to regulate general behaviors of cells. We and other two groups previously suggested that METCAM/MUC18 probably be utilized as a biomarker for predicting the malignant tendency of clinical ovarian carcinomas, since METAM/MUC18 expression appears to associate with the carcinoma at advan

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Imai, Atsushi, Tsukasa Ohno, Kyoko Takahashi, Tatsuro Furui, and Teruhiko Tamaya. "Lack of Evidence for Aromatase Expression in Human Ovarian Epithelial Carcinoma." Annals of Clinical Biochemistry: International Journal of Laboratory Medicine 31, no. 1 (1994): 65–71. http://dx.doi.org/10.1177/000456329403100111.

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It is controversial whether ovarian epithelial carcinoma possesses steroidogenic enzymes. We investigated aromatase expression in ovarian epithelial carcinoma, and compared it with the normal ovary and placenta. Samples were obtained from an ovarian carcinoma cell line SK-OV-3, ovarian tumour tissues from four patients with epithelial carcinoma and one patient with dysgerminoma. Aromatase enzymatic activity was measured in microsome fractions by quantitating 3H2O released from [1-3H]androstenedione and [3H]oestrone converted from [1,2,6,7-3H]androstenedione. Aromatase messenger ribonucleic aci

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3

Sidell, N., and I. R. Horowitz. "Reduced connexin 43 mRNA levels in human ovarian carcinoma." Journal of Clinical Oncology 24, no. 18_suppl (2006): 15071. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.15071.

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15071 Background: Cancer cells have been shown to exhibit many defects in gap junctions, which contribute to the loss of growth control and tissue homeostasis. In ovarian tissues, it is known that gap junction communication is predominantly mediated by connexin 43 (cx43) proteins. Recent studies have demonstrated that while human ovarian surface epithelial cells exhibit extensive expression of cx43, this protein is nearly absent in the vast majority of ovarian cancers. Differences in cx43 expression between normal and malignant ovarian tissue at the mRNA level has heretofore not been reported.

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Zhang, Li, Po Ding, Hongcheng Lv, et al. "Number of Polyploid Giant Cancer Cells and Expression of EZH2 Are Associated with VM Formation and Tumor Grade in Human Ovarian Tumor." BioMed Research International 2014 (2014): 1–9. http://dx.doi.org/10.1155/2014/903542.

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To investigate the associations among the number of polyploid giant cancer cells (PGCCs) and vasculogenic mimicry (VM), EZH2 expression, and serous ovarian tumor grade, a total of 80 paraffin-embedded serous ovarian tumor samples including 21 cases of primary carcinoma and their metastatic tumors, 26 cases of primary carcinoma without metastasis, and 12 cases of serous borderline cystadenoma were analyzed. PGCCs and VM were detected in human serous ovarian tumor. The metastatic foci of ovarian carcinoma had the highest number of PGCCs and VM. The number of PGCCs and VM increased with the grade

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FISHMAN, David A., Alicia KEARNS, Susan LARSH, Jan J. ENGHILD, and M. Sharon STACK. "Autocrine regulation of growth stimulation in human epithelial ovarian carcinoma by serine-proteinase-catalysed release of the urinary-type-plasminogen-activator N-terminal fragment." Biochemical Journal 341, no. 3 (1999): 765–69. http://dx.doi.org/10.1042/bj3410765.

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Ovarian carcinomas secrete single-chain urinary-type plasminogen activator (scuPA) and expression of uPA is up-regulated relative to normal ovarian epithelium, leading to an enhanced proteolytic capacity which may facilitate invasion. Furthermore, the uPA receptor (uPAR) is present on ovarian carcinoma cells and is occupied in tumour tissues. In the present study, incubation of scuPA with serum-free conditioned medium from ovarian carcinoma cells resulted in release of a 14 kDa polypeptide. N-terminal sequence analysis identified this fragment as the uPA N-terminal fragment (NTF), which contai

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Koon, E. C., P. C. Ma, R. Salgia, et al. "Effect of a c-Met-specific, ATP-competitive small-molecule inhibitor SU11274 on human ovarian carcinoma cell growth, motility, and invasion." International Journal of Gynecologic Cancer 18, no. 5 (2008): 976–84. http://dx.doi.org/10.1111/j.1525-1438.2007.01135.x.

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Increased expression of the receptor tyrosine kinase c-Met has been shown to correlate with enhanced cell proliferation, motility, and invasion. The objectives of this study were to characterize total and activated c-Met expression in both normal and malignant human ovarian epithelial cells and to determine the effects of inhibiting the activation of c-Met on ovarian epithelial cell growth, motility, and invasion. Total c-Met was overexpressed in 82 (68%) of 119 ovarian carcinomas, as shown by immunohistochemistry. Quantitative reverse transcription–polymerase chain reaction and Western blot a

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7

Zhang, W., N. Gan, and J. Zhou. "Immunohistochemical Investigation of the Correlation between LIM Kinase 1 Expression and Development and Progression of Human Ovarian Carcinoma." Journal of International Medical Research 40, no. 3 (2012): 1067–73. http://dx.doi.org/10.1177/147323001204000325.

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OBJECTIVES: LIM kinase 1 (LIMK1) is implicated in cellular mechanisms regulating tumour cell invasion and may be involved in ovarian carcinoma progression. This retrospective study, therefore, investigated expression of the LIMK1 gene in primary ovarian tumour tissue samples and evaluated the correlation between LIMK1 gene expression and progression of ovarian carcinoma. METHODS: LIMK1 protein levels were detected by immunohistochemistry in ovarian tissue samples from 57 patients with primary ovarian epithelial tumours (benign, n = 13; borderline, n = 14; carcinoma, n = 30) and 10 patients wit

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8

Nahar, Begum Afrin, Rama Saha, Chhanda Das, and Gourishankar Kamilya. "Immunohistochemical expression of human epididymis 4 in ovarian malignancy." International Journal of Research in Medical Sciences 7, no. 12 (2019): 4493. http://dx.doi.org/10.18203/2320-6012.ijrms20195506.

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Background: Ovarian malignancies has the highest mortality rate among all gynaecological malignancies. Surface epithelial tumors form two thirds of all ovarian neoplasm and 90% of all ovarian cancers are surface epithelial carcinomas. Mortality in case of ovarian malignancy is high due to late diagnosis. Early and accurate diagnosis can improve the case specific management. HE4 (Human Epididymis Protein 4) which is proved to be overexpressed in the ovarian cancer cells, is considered a new biomarker for ovarian cancer diagnosis which helps in early diagnosis and patient management. Aims and ob

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9

Tassi, R. A., E. Bignotti, M. Falchetti, et al. "Claudin-7 expression in human epithelial ovarian cancer." International Journal of Gynecologic Cancer 18, no. 6 (2008): 1262–71. http://dx.doi.org/10.1111/j.1525-1438.2008.01194.x.

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Claudin-7 (CLDN-7) is a tight junction protein recently found highly differentially expressed in ovarian carcinoma. To evaluate its potential as a novel biomarker, in this study, we quantified and compared claudin-7 expression at messenger RNA and protein level in 110 patients harboring various histologic types of epithelial ovarian carcinomas (EOC). CLDN-7 transcript was found significantly overexpressed in both primary and metastatic EOCs compared to normal human ovarian surface epithelium cell lines (fold change = 111.4, P< 0.001) by reverse transcription–polymerase chain reaction. At th

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10

Imai, Atsushi, Tsukasa Ohno, Kazuhiro Ohsuye, and Teruhiko Tamaya. "Expression of Gonadotropin-Releasing Hormone Receptor in Human Epithelial Ovarian Carcinoma." Annals of Clinical Biochemistry: International Journal of Laboratory Medicine 31, no. 6 (1994): 550–55. http://dx.doi.org/10.1177/000456329403100604.

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We have previously demonstrated the presence of gonadotropin-releasing hormone (Gn-RH) messenger ribonucleic acid (mRNA) in epithelial ovarian carcinoma. In this study, the expression of Gn-RH receptor (Gn-RHR) was investigated in human ovarian carcinoma and human ovarian carcinoma cell line. Gn-RHR was determined by [3H] Gn-RH binding assay. Gn-RHR mRNA was determined by reverse transcription-polymerase chain reaction using oligonucleotide primers synthesized based on published human Gn-RHR sequence. Specific Gn-RH binding sites were shown to be present in plasma membrane isolated from five o

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11

Lim, Whasun, Wooyoung Jeong, and Gwonhwa Song. "Coumestrol suppresses proliferation of ES2 human epithelial ovarian cancer cells." Journal of Endocrinology 228, no. 3 (2015): 149–60. http://dx.doi.org/10.1530/joe-15-0418.

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Coumestrol, which is predominantly found in soybean products as a phytoestrogen, has cancer preventive activities in estrogen-responsive carcinomas. However, effects and molecular targets of coumestrol have not been reported for epithelial ovarian cancer (EOC). In the present study, we demonstrated that coumestrol inhibited viability and invasion and induced apoptosis of ES2 (clear cell-/serous carcinoma origin) cells. In addition, immunoreactive PCNA and ERBB2, markers of proliferation of ovarian carcinoma, were attenuated in their expression in coumestrol-induced death of ES2 cells. Phosphor

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12

Hussein, Usama Khamis, Asmaa Gamal Ahmed, Won Ku Choi, et al. "SCRIB Is Involved in the Progression of Ovarian Carcinomas in Association with the Factors Linked to Epithelial-to-Mesenchymal Transition and Predicts Shorter Survival of Diagnosed Patients." Biomolecules 11, no. 3 (2021): 405. http://dx.doi.org/10.3390/biom11030405.

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SCRIB is a polarity protein important in maintaining cell junctions. However, recent reports have raised the possibility that SCRIB might have a role in human cancers. Thus, this study evaluated the roles of SCRIB in ovarian cancers. In 102 human ovarian carcinomas, nuclear expression of SCRIB predicted shorter survival of ovarian carcinoma patients, especially in the patients who received post-operative chemotherapy. In SKOV3 and SNU119 ovarian cancer cells, overexpression of SCRIB stimulated the proliferation and invasion of cells. Knockout of SCRIB inhibited in vivo tumor growth of SKOV3 ce

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13

Chan, Thomas C. K. "Calcium-independent growth of human ovarian carcinoma cells." Journal of Cellular Physiology 141, no. 3 (1989): 461–66. http://dx.doi.org/10.1002/jcp.1041410303.

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14

Rieppi, Monica, Veronica Vergani, Carmen Gatto, et al. "Mesothelial cells induce the motility of human ovarian carcinoma cells." International Journal of Cancer 80, no. 2 (1999): 303–7. http://dx.doi.org/10.1002/(sici)1097-0215(19990118)80:2<303::aid-ijc21>3.0.co;2-w.

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15

Qian, H. N., G. Z. Liu, S. J. Cao, J. Feng та X. Ye. "The experimental study of ovarian carcinoma vaccine modified by human B7-1 and IFN-γ genes". International Journal of Gynecologic Cancer 12, № 1 (2002): 80–85. http://dx.doi.org/10.1136/ijgc-00009577-200201000-00013.

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Abstract.Qian HN, Liu GZ, Cao SJ, Feng J, Ye X. The experimental study of ovarian carcinoma vaccine modified by human B7-1 and IFN-γ genes.With the advance of immunology, immunogene therapy is becoming a possible therapeutic alternative to advanced cancer. The aim of tumor immunogene therapy is to enhance the immune response to tumors. Evidence suggests that CD80 (B7-1) and Interferon-gamma (IFN-γ) play important roles in antitumor immunity induced by T lymphocyte. To study the antitumor immune effects of ovarian carcinoma vaccine modified with human B7-1 and IFN-γ genes, we constructed the bi

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16

Kalli, Kimberly R., Oluwole I. Falowo, Laurie K. Bale, Michael A. Zschunke, Patrick C. Roche, and Cheryl A. Conover. "Functional Insulin Receptors on Human Epithelial Ovarian Carcinoma Cells: Implications for IGF-II Mitogenic Signaling." Endocrinology 143, no. 9 (2002): 3259–67. http://dx.doi.org/10.1210/en.2001-211408.

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Abstract The insulin receptor mediates a proliferative response in certain transformed cells, but little is known about its function in ovarian cancer. We used human epithelial ovarian carcinoma cell lines and lifespan-extended normal ovarian surface epithelial (OSE) cells to examine 125I-insulin binding and mitogenic responses to insulin. All cancer cell and OSE cultures specifically bound 125I-insulin. Except for OV202, the carcinoma lines had elevated insulin binding compared with OSE cells. All carcinoma lines except OV202 expressed insulin receptor as detected by flow cytometry and increa

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17

Zhou, Qiang, Minghua Deng, and Jianping Gong. "The role of long non-coding RNAs in human carcinoma." International Surgery Journal 7, no. 11 (2020): 3861. http://dx.doi.org/10.18203/2349-2902.isj20204711.

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Long non-coding RNAs (LncRNAs) are usually longer than 200 nucleotides in length, which have 4 functions including signal, decoy, guide and scaffold in cells. Many studies have shown that the expression of LncRNAs is differentially between normal tissues and cancers, including hepatocellular carcinoma (HCC), bladder cancer, epithelial ovarian cancer, gastric cancer and other cancers, which suggests that alterations in the expression of LncRNAs could promote or inhibit tumor growth. However, the exact mechanisms by which LncRNAs play their roles in the normal and tumor cells remain unclear. Thi

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18

Pettinari, Riccardo, Fabio Marchetti, Claudio Pettinari, et al. "Organometallic rhodium(iii) and iridium(iii) cyclopentadienyl complexes with curcumin and bisdemethoxycurcumin co-ligands." Dalton Transactions 44, no. 47 (2015): 20523–31. http://dx.doi.org/10.1039/c5dt03037d.

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19

Javid, F. A., and S. Afshinjavid. "The effect of fluoxetine on human ovarian carcinoma cells." Clinical Therapeutics 37, no. 8 (2015): e35. http://dx.doi.org/10.1016/j.clinthera.2015.05.109.

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20

Rao, Yang, Wenwen Zhang, Dan Li, Xiao Li, Yaomei Ma, and Pengpeng Qu. "Circ TYMP1 Inhibits Carcinogenesis and Cisplatin Resistance in Ovarian Cancer by Reducing Smad2/3 Phosphorylation via a MicroRNA-182A-3p/TGF1B Axis." Contrast Media & Molecular Imaging 2022 (August 16, 2022): 1–9. http://dx.doi.org/10.1155/2022/1032557.

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TYMP1 is a cancer driver in several human malignancies. However, its significance in ovarian cancer (ovarian carcinoma) remains uncertain. This research aims to understand the TYMP1’s role in ovarian carcinoma carcinogenesis and cisplatin (DDP) resistance and its molecular ovarian marchionesses. Circ TYMP1 overexpression in ovarian carcinoma samples led to an accelerated tumor stage. Bioinformatics identified miR-182A-3p as the TYMP1’s target transcript. Circ TYMP1 functioned as a sponge for miR-182A-3p, lowering its inhibitory effect on TGF1B. Downregulating circ TYMP1 decreased A2780-Res cel

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21

Chung, Yuan-Chiang, Li-Cheng Lu, Ming-Hsiu Tsai, et al. "The Inhibitory Effect of Ellagic Acid on Cell Growth of Ovarian Carcinoma Cells." Evidence-Based Complementary and Alternative Medicine 2013 (2013): 1–12. http://dx.doi.org/10.1155/2013/306705.

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Ellagic acid (EA) is able to inhibit the growth of several cancer cells; however, its effect on human ovarian carcinoma cells has not yet been investigated. Ovarian carcinoma ES-2 and PA-1 cells were treated with EA (10~100 μM) and assessed for viability, cell cycle, apoptosis, anoikis, autophagy, and chemosensitivity to doxorubicin and their molecular mechanisms. EA inhibited cell proliferation in a dose- and time-dependent manner by arresting both cell lines at the G1 phase of the cell cycle, which were from elevating p53 and Cip1/p21 and decreasing cyclin D1 and E levels. EA also induced ca

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22

Surowiak, P., M. DrĄG, V. Materna, et al. "Expression of aminopeptidase N/CD13 in human ovarian cancers." International Journal of Gynecologic Cancer 16, no. 5 (2006): 1783–88. http://dx.doi.org/10.1136/ijgc-00009577-200609000-00010.

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Aminopeptidase N/CD13 (EC 3.4.11.2) is suggested to play a role in cancer cells invasion, and its activity can be inhibited using specific inhibitors. CD13 inhibitors evoke apoptosis of CD13-positive cancer cells. However, expression of CD13 has not been described in specimens obtained from ovarian carcinomas. Thus, in the present study, the expression of CD13 and its significance was examined in samples of ovarian cancers. The analyses were performed on sections originating from 73 tumor samples (43 from primary laparotomies [PL] and 30 from secondary cytoreductions [SCRs]). Immunohistochemic

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23

Katz, Yeshayahu, Gilad Ben-Baruch, Yoel Kloog, Joseph Menczer, and Moshe Gavish. "Increased density of peripheral benzodiazepine-binding sites in ovarian carcinomas as compared with benign ovarian tumours and normal ovaries." Clinical Science 78, no. 2 (1990): 155–58. http://dx.doi.org/10.1042/cs0780155.

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1. Benzodiazepines are involved in the control of proliferation and differentiation of normal and malignant cells in vitro. This regulatory ability is probably mediated via peripheral benzodiazepine-binding sites. 2. In the present study we compared the binding characteristics of peripheral benzodiazepine-binding sites in human epithelial ovarian carcinoma with those in benign ovarian tumours and normal ovaries. 3. The affinity and density of peripheral benzodiazepine-binding sites in homogenate preparations of ovarian carcinoma as compared with benign ovarian tumours and with normal tissues (

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24

Ma, Jun, Jie Yang, Chao Wang, et al. "Emodin Augments Cisplatin Cytotoxicity in Platinum-Resistant Ovarian Cancer Cells via ROS-Dependent MRP1 Downregulation." BioMed Research International 2014 (2014): 1–8. http://dx.doi.org/10.1155/2014/107671.

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The intracellular level of reactive oxygen species (ROS) is closely associated with chemosensitivity of cancer cells. Overexpression of ATP binding cassette transporter MRP1 is correlated with resistance to platinum drugs. In this study, we tested the hypothesis that emodin, a potent ROS generator, may increase sensitivity of cisplatin-(cDDP-) resistant ovarian carcinoma cells to cDDP cytotoxicity via ROS-mediated suppression of MRP1 expression. Using the isogenic pair of the human ovarian carcinoma cell line COC1 and its cDDP resistant variant COC1/DDP, we found that ROS level in the cDDP-sen

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25

GUO, H. F., J. FENG, G. LIU, et al. "Establishment and characterization of a human ovarian sarcomatoid carcinoma cell line BUPH: OVSC." International Journal of Gynecologic Cancer 15, no. 5 (2005): 856–65. http://dx.doi.org/10.1136/ijgc-00009577-200509000-00023.

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We first established a human ovarian sarcomatoid carcinoma cell line designated BUPH:OVSC from primary culture. The specimen was derived from the mural nodule in an ovarian mucinous tumor and culturedin vitro. To date, the cell line has been maintained for over 100 passages. Its biologic characteristics were studied by light and electron microscopy, which revealed spindle-shaped or polygonal cells with a doubling time of 39.5 h. The agglutination test of BUPH:OVSC was positive, and cell colonies were formed in soft agar. Chromosome analysis revealed its karyotype to be a pseudodiploidy. One X

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26

Kurrasch, R. H., A. V. Rutherford, M. E. Rick, et al. "Characterization of a monoclonal antibody, OVB1, which binds to a unique determinant in human ovarian carcinomas and myeloid cells." Journal of Histochemistry & Cytochemistry 37, no. 1 (1989): 57–67. http://dx.doi.org/10.1177/37.1.2461982.

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A monoclonal antibody, OVB1, was generated against a human ovarian carcinoma cell line, OVCAR-3. The antigen reacting with this antibody was strongly expressed on the external surface of the plasma membrane of OVCAR-3 cells and cells of 4/4 other ovarian carcinoma lines. Variable density and homogeneity of expression was found on cells from 5/5 breast carcinoma lines. Various ovarian tumor specimens and normal human tissues were frozen, cryostat-sectioned, and examined for OVB1 reactivity using immunoperoxidase methods. A strong, uniform, homogeneous reaction on 10/10 ovarian carcinoma specime

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Reader, Jocelyn C., Cong Fan, Eleanor Claire-Higgins Ory, et al. "Microtentacle Formation in Ovarian Carcinoma." Cancers 14, no. 3 (2022): 800. http://dx.doi.org/10.3390/cancers14030800.

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Background: The development of chemoresistance to paclitaxel and carboplatin represents a major therapeutic challenge in ovarian cancer, a disease frequently characterized by malignant ascites and extrapelvic metastasis. Microtentacles (McTNs) are tubulin-based projections observed in detached breast cancer cells. In this study, we investigated whether ovarian cancers exhibit McTNs and characterized McTN biology. Methods: We used an established lipid-tethering mechanism to suspend and image individual cancer cells. We queried a panel of immortalized serous (OSC) and clear cell (OCCC) cell line

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Holm, Jan, Steen Ingemann Hansen, Mimi Høier-Madsen, and Poul-Erik Helkjær. "A Folate Binding Protein in Ascitic Fluid, Serum and Ovarian Tissue of Patients with Ovarian Adenocarcinoma Immunoreacts with Antibodies Against Human Milk Folate Binding Protein." Bioscience Reports 18, no. 2 (1998): 49–57. http://dx.doi.org/10.1023/a:1020174325204.

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The presence of a folate binding protein which immunoreacts with antibodies against human milk folate binding protein was demonstrated in ascitic fluids from seven patients with ovarian adenocarcinoma. Ascitic fluids collected from two patients with other malignancies contained non-immunoreactive FBP. Tumor tissue specimens from five patients with ovarian carcinoma contained immunoreactive FBP. By contrast to normal ovaries ovarian carcinoma tissue showed positive immunostaining on immunohistochemistry. Ascitic fluids from two patients with ovarian carcinoma exhibited single distinct bands on

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Brown, Geoffrey. "Targeting the Retinoic Acid Pathway to Eradicate Cancer Stem Cells." International Journal of Molecular Sciences 24, no. 3 (2023): 2373. http://dx.doi.org/10.3390/ijms24032373.

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All-trans retinoic acid is a morphogen during embryogenesis and a teratogen. Cancer is an error of development, and the retinoic acid receptors (RAR) for all-trans retinoic acid play a role in cancer. Expression of the cytosolic aldehyde dehydrogenases, which mediate the last step to the synthesis of all-trans retinoic acid, is deregulated in various human cancers. Inhibiting these enzymes using a variety of agents reduced the proliferation of lung cancer cells, reduced the proliferation and induced apoptosis of ovarian, prostate, squamous, and uterine cancer cells, and sensitised breast, colo

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Wei, Shuang, Ilona Kryczek, Linhua Zou, et al. "Plasmacytoid Dendritic Cells Induce CD8+ Regulatory T Cells In Human Ovarian Carcinoma." Cancer Research 65, no. 12 (2005): 5020–26. http://dx.doi.org/10.1158/0008-5472.can-04-4043.

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Walton, James W., Jasmine M. Cross, Tina Riedel, and Paul J. Dyson. "Perfluorinated HDAC inhibitors as selective anticancer agents." Organic & Biomolecular Chemistry 15, no. 43 (2017): 9186–90. http://dx.doi.org/10.1039/c7ob02339a.

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Perfluorinated histone deacetylase inhibitors show more potent cytotoxicity and greater selectivity towards ovarian carcinoma cells over human embryonic kidney cells, compared to the clinically-approved inhibitor, SAHA.

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Prinetti, Alessandro, Danilo Millimaggi, Sandra D'Ascenzo, et al. "Lack of ceramide generation and altered sphingolipid composition are associated with drug resistance in human ovarian carcinoma cells." Biochemical Journal 395, no. 2 (2006): 311–18. http://dx.doi.org/10.1042/bj20051184.

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PTX (Paclitaxel®) is an antimitotic agent used in the treatment of a number of major solid tumours, particularly in breast and ovarian cancer. This study was undertaken to gain insight into the molecular alterations producing PTX resistance in ovarian cancer. PTX treatment is able to induce apoptosis in the human ovarian carcinoma cell line, CABA I. PTX-induced apoptosis in CABA I cells was accompanied by an increase in the cellular Cer (ceramide) levels and a decrease in the sphingomyelin levels, due to the activation of sphingomyelinases. The inhibition of acid sphingomyelinase decreased PTX

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Bae, Hyocheol, Gwonhwa Song, and Whasun Lim. "Stigmasterol Causes Ovarian Cancer Cell Apoptosis by Inducing Endoplasmic Reticulum and Mitochondrial Dysfunction." Pharmaceutics 12, no. 6 (2020): 488. http://dx.doi.org/10.3390/pharmaceutics12060488.

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Background: Phytosterols have physiological effects and are used as medicines or food supplements. Stigmasterol has shown anticancer effects against various cancers such as hepatoma, cholangiocarcinoma, gall bladder carcinoma, endometrial adenocarcinoma and skin, gastric, breast, prostate, and cervical cancer. However, there are no reports on stigmasterol’s effects on ovarian cancer. Methods: We investigated the effects of stigmasterol on proapoptotic signals, mitochondrial function, reactive oxygen species production, and the cytosolic and mitochondrial calcium levels in human ovarian cancer

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Gao, Ying, Junfeng Yin, Youying Tu, and Yi Chen. "Theaflavin-3,3′-Digallate Suppresses Human Ovarian Carcinoma OVCAR-3 Cells by Regulating the Checkpoint Kinase 2 and p27 kip1 Pathways." Molecules 24, no. 4 (2019): 673. http://dx.doi.org/10.3390/molecules24040673.

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Theaflavin-3,3′-digallate (TF3) is a unique polyphenol in black tea. Epidemiological studies have proved that black tea consumption decreases the incidence rate of ovarian cancer. Our former research demonstrated that TF3 inhibited human ovarian cancer cells. Nevertheless, the roles of checkpoint kinase 2 (Chk2) and p27 kip1 (p27) in TF3-mediated inhibition of human ovarian cancer cells have not yet been investigated. In the current study, TF3 enhanced the phosphorylation of Chk2 to modulate the ratio of pro/anti-apoptotic Bcl-2 family proteins to initiate intrinsic apoptosis in a p53-independ

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Adham, Sirin A. I., Ifat Sher, and Brenda L. Coomber. "Molecular blockade of VEGFR2 in human epithelial ovarian carcinoma cells." Laboratory Investigation 90, no. 5 (2010): 709–23. http://dx.doi.org/10.1038/labinvest.2010.52.

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Rose, Stephen L., Matthew P. Fitzgerald, Natalie O. White, et al. "Epigenetic regulation of maspin expression in human ovarian carcinoma cells." Gynecologic Oncology 102, no. 2 (2006): 319–24. http://dx.doi.org/10.1016/j.ygyno.2005.12.025.

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Andrews, Paul A., Michael P. Murphy, and Stephen B. Howell. "Characterization of cisplatin-resistant COLO 316 human ovarian carcinoma cells." European Journal of Cancer and Clinical Oncology 25, no. 4 (1989): 619–25. http://dx.doi.org/10.1016/0277-5379(89)90195-8.

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Tong, Lu, Wenjiao Cao, Jun Sheng, et al. "RDM1 plays an oncogenic role in human ovarian carcinoma cells." Artificial Cells, Nanomedicine, and Biotechnology 48, no. 1 (2020): 885–92. http://dx.doi.org/10.1080/21691401.2020.1770267.

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Canaday, Daniel, Ming Zeng, George Cerniglia, and Craig W. Stevens. "2018 Radiation improves gene tranfer into human ovarian carcinoma cells." International Journal of Radiation Oncology*Biology*Physics 39, no. 2 (1997): 249. http://dx.doi.org/10.1016/s0360-3016(97)80787-0.

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40

Teyssier, Jean Raymond, Jean Bénard, Daniel Ferre, Jacqueline Da Silva, and Laurence Renaud. "Drug-related chromosomal changes in chemoresistant human ovarian carcinoma cells." Cancer Genetics and Cytogenetics 39, no. 1 (1989): 35–43. http://dx.doi.org/10.1016/0165-4608(89)90227-6.

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Fernstrom, Martha J., Lucas D. Koffler, George Abou-Rjaily, Paul D. Boucher, Donna S. Shewach, and Randall J. Ruch. "Neoplastic Reversal of Human Ovarian Carcinoma Cells Transfected with Connexin43." Experimental and Molecular Pathology 73, no. 1 (2002): 54–60. http://dx.doi.org/10.1006/exmp.2002.2436.

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Yaşayan, Gökçen, Oya Orun, Pınar Mega Tiber, Veronika Rožman, and Sevgi Koçyiğit Sevinç. "The interactions of human ovarian cancer cells and nanotextured surfaces: cell attachment, viability and apoptosis studies." RSC Advances 9, no. 45 (2019): 25957–66. http://dx.doi.org/10.1039/c9ra03783g.

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Vetro, Maria, Barbara Costa, Giulia Donvito, et al. "Anionic glycolipids related to glucuronosyldiacylglycerol inhibit protein kinase Akt." Organic & Biomolecular Chemistry 13, no. 4 (2015): 1091–99. http://dx.doi.org/10.1039/c4ob01602e.

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Watanabe, Megumi, Motoki Matsuura, Tatsuya Sato, et al. "Fatty Acid Metabolism Regulators Have Pivotal Roles in the Pathogenesis of Ovarian Carcinoma." International Journal of Molecular Sciences 26, no. 10 (2025): 4794. https://doi.org/10.3390/ijms26104794.

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To study the pathological contribution of fatty acid (FA) metabolism regulators including fatty acid binding protein 4 (FABP4), FABP5, peroxisome proliferator-activated receptor alpha (PPARα), and PPARγ in ovarian carcinoma, non-cancerous human ovarian surface epithelium (HOSE) cells and two epithelial ovarian carcinoma (EOC) cell lines, AMOC-2 and ES2 established from ovarian serous adenocarcinoma and ovarian clear cell carcinoma, respectively, were subjected to (1) an analysis of the physical properties of spheroids, (2) qPCR analysis, (3) cellular metabolic analysis, and (4) multiomic pan-c

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Kutlvasr, K., K. Bukovjan, and R. Kodet. "Bilateral low grade serous adenocarcinoma of the ovaries in a badger (Meles meles L.) and its association with a borderline serous ovarian tumour: a case report." Veterinární Medicína 59, No. 1 (2014): 44–50. http://dx.doi.org/10.17221/7245-vetmed.

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Here, we describe a case of a wild female badger (a sow) with disseminated serous adenocarcinoma of the ovary which corresponds to a group of low grade serous carcinomas of the ovary in humans. Beside grossly apparent dissemination of the disease we observed a scale of histological features classifiable as a precursor lesion &ndash; borderline serous tumour of the ovary with implant metastases at the peritoneum, and features of the borderline tumour transformation in the carcinoma. The latter features included invasion of some of the metastatic peritoneal implants into the adipose tissue o

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Nakazato, T., T. Kanuma, T. Tamura, L. S. Faried, H. Aoki, and T. Minegishi. "Sperm protein 17 influences the tissue-specific malignancy of clear cell adenocarcinoma in human epithelial ovarian cancer." International Journal of Gynecologic Cancer 17, no. 2 (2007): 426–32. http://dx.doi.org/10.1111/j.1525-1438.2007.00815.x.

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Clear cell adenocarcinoma of the ovary has a poor prognosis due to chemoresistance and early metastasis to the lymph nodes. It also can result in endometriosis and is the second most frequent type of ovarian cancer in Japan. Serous adenocarcinoma of the ovary is another common epithelial cancer tissue subtype in Japan, and it is highly sensitive to chemotherapy. In the current study, we examined the differential expression of genes in these types of ovarian cancer and tried to analyze their functions, especially as they relate to chemoresistance. We used differential display to compare clear c

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Su, Xiu-Zhen, Ran Chen, Cai-Bing Wang, Xi-Lin Ouyang, Yan Jiang, and Ming-Yi Zhu. "Astaxanthin Combine with Human Serum Albumin to Abrogate Cell Proliferation, Migration, and Drug-resistant in Human Ovarian Carcinoma SKOV3 Cells." Anti-Cancer Agents in Medicinal Chemistry 19, no. 6 (2019): 792–801. http://dx.doi.org/10.2174/1871520619666190225123003.

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Background: Astaxanthin (AST) shows a large range of beneficial effects together with anti-cancer and antioxidation properties. Human Serum Albumin (HSA) is the most abundant protein in blood plasma which plays the role of a depot and transport protein for many exogenous compounds. However, whether HSA could enhance AST-induced cytotoxic effects in human ovarian cancer cells has not been examined to date. Objective: This study aims to explore the anticancer effect and the molecular mechanism of AST combine with HSA induced cytotoxicity in ovarian cancer SKOV3 cells. Methods: The ovarian cancer

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Wang, Chia-Woei, Chien-Kai Wang, Yu-Jia Chang, et al. "Preclinical Evaluation on the Tumor Suppression Efficiency and Combination Drug Effects of Fermented Wheat Germ Extract in Human Ovarian Carcinoma Cells." Evidence-Based Complementary and Alternative Medicine 2015 (2015): 1–8. http://dx.doi.org/10.1155/2015/570785.

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Fermented wheat germ extract (FWGE) is a nutrient supplement and a potential antitumor ingredient for developing an integrated chemotherapy with standard chemotherapeutic drugs for treating ovarian cancer patients. In this study, we evaluated the tumor suppression efficiency of FWGE in human ovarian carcinoma cells, SKOV-3 and ES-2, and found the half-maximal inhibitory concentrations (IC50s) to be 643.76 μg/mL and 246.11 μg/mL after 48 h of FWGE treatment. FWGE treatment also induced programmed cell death by activating the caspase-7 cleavage in both SKOV-3 and ES-2 cells, but only caspase-3 a

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Li, Yi, Ming Xiao, and Fangchun Guo. "The role of Sox6 and Netrin-1 in ovarian cancer cell growth, invasiveness, and angiogenesis." Tumor Biology 39, no. 5 (2017): 101042831770550. http://dx.doi.org/10.1177/1010428317705508.

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SOX6 plays important roles in cell proliferation, differentiation, and cell fate determination. It has been confirmed that SOX6 is a tumor suppressor and downregulated in various cancers, including esophageal squamous cell carcinoma, hepatocellular carcinoma, and chronic myeloid leukemia. Netrin-1 is highly expressed in various human cancers and acts as an anti-apoptotic and proangiogenic factor to drive tumorigenesis. The role of SOX6 and netrin-1 in regulating the growth of ovarian tumor cells still remains unclear. Real-time polymerase chain reaction and western blot were used to determine

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Zhang, S., Q. D. Lin, and W. Di. "Suppression of human ovarian carcinoma metastasis by the metastasis‐suppressor gene,BRMS1." International Journal of Gynecologic Cancer 16, no. 2 (2006): 522–31. http://dx.doi.org/10.1136/ijgc-00009577-200603000-00010.

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Metastasis-suppressor genes, by definition, suppress metastasis without affecting tumorigenicity and, hence, present attractive targets as prognostic or therapeutic markers.BRMS1(breast cancer metastasis suppressor) has recently been identified as a metastasis-suppressor gene for human breast cancer and melanoma. Expression ofBRMS1messenger RNA (mRNA) in multitissue including normal prostate, ovarian, testis, and colon has been detected by northern blot analysis. We hypothesize that the role ofBRMS1in tumor progression may not be limited to breast cancer and melanoma. We previously found thatB

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