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Dissertations / Theses on the topic 'Human Parvovirus B19'

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Published: 4 June 2021

Last updated: 15 June 2025

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1

Isa, Adiba. "Cellular immune responses against human parvovirus B19 infection /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-662-X/.

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2

Blundell, Matthew Charles. "Characterization of the promoter in a human B19 parvovirus." Thesis, University of British Columbia, 1989. http://hdl.handle.net/2429/29011.

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The nucleotide sequence of the B19-Wi isolate of an autonomous human parvovirus was determined and compared with the sequence of the closely related isolate, B19-Au. The B19-Wi genome was similar to the B19-Au genome, as shown from DNA sequence analyses. It had been previously suggested from the sequence of the B19-Au genome, that the termini may be imperfect inverted terminal repeats. The additional sequence present on the right-hand terminus of B19-Wi supported that supposition. The hairpin termini of the B19 genome were of the same type as those found in adeno-associated parvoviruses, and s

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3

Tolfvenstam, Thomas. "Human parvovirus B19 : studies on the pathogenesis of infection /." Stockholm, 2001. http://diss.kib.ki.se/2001/91-628-4710-4/.

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4

Norbeck, Oscar. "Clinical and immunological aspects of human parvovirus B19 infection /." Stockholm : Dept. of laboratory medicine, Karolinska institutet, 2005. http://diss.kib.ki.se/2005/91-7140-203-9/.

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5

Heegaard, Erik D. "Diagnostic and clinical aspects of human parvovirus B19 infection /." [S.l. : Erik D. Heegaard], 2003. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=010694314&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.

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6

Morey, Adrienne Louise. "The pathogenesis of parvovirus B19 infection in the human fetus." Thesis, University of Oxford, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.316848.

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7

Carlsen, Karen Marie. "Human parvovirus B19 erythrovirus : methods established for virological and diagnostic aspects /." Copenhagen : Blackwell Munksgaard, 2006. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=014982739&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.

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8

Lundqvist, Anders. "Clinical and laboratory findings in patients with persistent parvovirus 19 infection /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-828-2/.

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9

Sanchez, Jonathan L., Zachary Romero, Angelica Quinones, Kristiane R. Torgeson, and Nancy C. Horton. "DNA Binding and Cleavage by the Human Parvovirus B19 NS1 Nuclease Domain." AMER CHEMICAL SOC, 2016. http://hdl.handle.net/10150/622382.

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Infection with human parvovirus B19 (B19V) has been associated with a myriad of illnesses, including erythema infectiosum (Fifth disease), hydrops fetalis, arthropathy, hepatitis, and cardiomyopathy, and also possibly the triggering of any number of different autoimmune diseases. B19V NS1 is a multidomain protein that plays a critical role in viral replication, with predicted nuclease, helicase, and gene transactivation activities. Herein, we investigate the biochemical activities of the nuclease domain (residues 2-176) of B19V NS1 (NS1-nuc) in sequence-specific DNA binding of the viral origin

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10

Wildig, James William. "The contribution of Human parvovirus B19 infection to cases of severe anaemia among young children in Malaria endemic areas." Thesis, The University of Sydney, 2008. https://hdl.handle.net/2123/28139.

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Human Parvovirus BI9 (BI9) is a common virus with worldwide distribution. Acute infection causes cessation of erythropoiesis for 5 - 7 days. This viral suppression of bone marrow leads to a decrease in the haemoglobin level of the infected individual. Cases of severe anaemia induced by B19 infection have been described in people with underlying haematological disorders such as Sickle Cell disease, as well as children with malaria and iron deficiency. Among young children in malaria endemic areas anaemia is extremely common. The aetiology of this is complex with multiple contributing fa

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11

Conti, Ilaria <1990&gt. "Human Parvovirus B19: from the development of a reverse genetics system to antiviral strategies." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2019. http://amsdottorato.unibo.it/8773/1/Conti_Ilaria_tesi.pdf.

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Human Parvovirus B19 (B19V) is a human pathogenic virus and responsible for various clinical manifestations, although neither an antiviral therapy nor a vaccine are available. Difficulties for B19V propagation and characterization are caused by its narrow tropism for the erythroid progenitor cells of human bone marrow and the very few cell lines that can support the viral replication. In this research, a reverse genetic approach was first developed to allow the generation of mature and infectious viral particles from a designed viral consensus sequence. Synthetic clones that differ for their

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12

Danober, Pascal Masutti Jean-Pierre. "Découverte d'un cas de sphérocytose héréditaire au décours d'une infection à Parvovirus B19 chez l'enfant à propos d'une observation /." [S.l] : [s.n], 2004. http://www.scd.uhp-nancy.fr/docnum/SCDMED_T_2004_DANOBER_PASCAL.pdf.

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13

Garcia, Sheila de Oliveira. "O significado das variantes do eritrovírus em pacientes com citopenias de origem desconhecida." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/5/5164/tde-03112010-172833/.

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O eritrovírus humano (parvovírus), gênero Erytrovírus, é o único representante da família Parvoviridae responsável por um amplo espectro de doenças. Estudos recentes têm demonstrado variações entre o eritrovírus e orientam a reclassificação destas variantes em três genótipos distintos: genótipos 1, 2 e 3. O papel do eritrovírus na etiopatogenia de doenças hematológicas em humanos permanece incerto. Este estudo teve como objetivo principal avaliar a relação etiopatogênica dos genótipos do eritrovírus e as citopenias de origem desconhecida. Materiais e Métodos: Participaram do estudo 285 indivíd

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14

Chaput, CeÌcile Claire. "The establishment of an infectivity assay for human parvovirus B19 to investigate the efficacy of protocols for the inactivation of pathogens from plasma products." Thesis, Open University, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.434971.

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15

SALVETE, MARIE-JOSE. "Les infections a parvovirus humain b19 : une pathologie sous-estimee ?" Limoges, 1989. http://www.theses.fr/1989LIMO0133.

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16

Pallier-Kerestedjian, Coralie. "Etude de la permissivité cellulaire A : la réplication du parvovirus humain B19." Paris 5, 1994. http://www.theses.fr/1994PA05P160.

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17

Guiramand, Sonia. "Production de la protéine non structurale du parvovirus humain B19 en système procaryote." Paris 5, 1996. http://www.theses.fr/1996PA05P191.

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18

UNGIER, SERGE. "Madalie de minskowski-chauffard revelee par une erythroblastopenie aigue a parvovirus humain b19 : a propos de deux observations." Lille 2, 1992. http://www.theses.fr/1992LIL2M054.

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19

Pillet, Sylvie. "Synthèse et transport des protéines de capside du parvovirus humain B19 dans les cellules primaires érythroi͏̈des CD36+." Paris 7, 2002. http://www.theses.fr/2002PA077152.

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20

Sol, Nathalie. "Etude de l'interaction de la protéine NS1 du parvovirus humain B19 avec la région LTR du rétrovirus VIH1." Paris 5, 1992. http://www.theses.fr/1992PA05P004.

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21

Camus, Tobar Carolina. "Detección de Parvovirus B19 en muestras de pacientes con manifestaciones clínicas asociadas a la infección con el virus." Tesis, Universidad de Chile, 2011. http://repositorio.uchile.cl/handle/2250/131186.

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Memoria para optar al Título Profesional de Médico Veterinario<br>Fundamentos: Parvovirus B19 (PV-B19) pertenece a la familia Parvoviridae, género Eritrovirus. Es un virus ADN de hebra simple que presenta secuencias palindrómicas en sus extremos. Es muy prevalente en la población general, llegando a detectarse anticuerpos anti PV-B19 en más del 85% de la población geriátrica. Este virus es el agente causal de una amplia gama de manifestaciones clínicas, cuya severidad depende del estado inmunológico y hematológico del hospedero, e incluye el eritema infeccioso, problemas hematológicos y reumat

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22

Leruez-Ville, Marianne. "La proteine non structurale du parvovirus humain b19 : role dans l'infection semi-permissive, production par un clone cellulaire stable et interaction avec le promoteur (doctorat : microbiologie)." Paris 11, 1998. http://www.theses.fr/1998PA114832.

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23

Morinet, Frédéric. "Production des antigenes structuraux du parvovirus humain b19 par expression des proteines de capside dans escherichia coli; leur utilisation pour developper un test diagnostic." Paris 7, 1990. http://www.theses.fr/1990PA077067.

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Le diagnostic de la plupart des infections humaines a parvovirus b19 repose sur la mise en evidence d'igm specifiques. En l'absence de systeme de culture cellulaire de routine permettant de produire du virus b19, seuls les serums de sujets viremiques representent la source d'antigene utile au diagnostic serologique. Pour pallier a cet inconvenient, nous avons clone un fragment de 1,4 kbp d'adn b19 situe dans la portion droite du genome; celle-ci code pour les proteines de capside. Ce fragment de 1,4 kbp a ete exprime en systeme prokaryote et a permis l'obtention de proteine hybride comportant

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24

N'Guyen, Yohan. "Détection moléculaire des formes complètes et tronquées en région 5’non codante des Entérovirus et conséquences sur la réponse inflammatoire chez des patients souffrant de myocardite ou de cardiomyopathie dilatée Virus detection and semiquantitation in explanted heart tissues of idiopathic dilated cardiomyopathy adult patients by use of PCR coupled with mass spectrometry analysis Enterovirus but not Parvovirus B19 is associated with idiopathic dilated cardiomyopathy and endomyocardial CD3, CD68, or HLA-DR expression Major Persistent 5' Terminally Deleted Coxsackievirus B3 Populations in Human Endomyocardial Tissues Enterovirus Persistence in Cardiac Cells of Patients With Idiopathic Dilated Cardiomyopathy Is Linked to 5' Terminal Genomic RNA-Deleted Viral Populations With Viral-Encoded Proteinase Activities." Thesis, Reims, 2019. http://www.theses.fr/2019REIMM203.

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Des ARN génomiques d’Enterovirus (EV) tronqués en région 5’ Non-Codante ont été détectés dans les tissus cardiaques de cas de myocardite aigue et de cardiomyopathie dilatée (CMD). La cinétique d’apparition de ces formes virales cardiaques et leurs conséquences sur la réponse inflammatoire sont inconnues. Une technique de PCR-MS a permis de détecter des ARN d’EV seuls (32%) ou associés à l’ADN du PVB19 (48%) chez des patients souffrant de CMD idiopathique. Chez ces patients, la présence exclusive d’ARN EV était associée avec un immunomarquage endomyocardique positif pour CD3, CD68 ou HLA-DR. Da

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25

Huai-Sheng and 許懷升. "Baculovirus Expression of Human Parvovirus B19 Structural Protein." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/46574514128498032351.

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碩士<br>中山醫學大學<br>免疫學研究所<br>99<br>Previous studies have indicated that the capsids of human parvovirus B19 are composed of VP1 and VP2 proteins, also expression of VP2 alone in eukaryotic expression system could self-assemble into empty capsids, no matter in size, appearance, antigenicity or immunogenicity are similar to native virions. The empty capsids which without genetic materials are called virus-like particles (VLPs). We used Spodoptera frugiperda (Sf9) cells infected with recombinant baculovirus expressing B19 VP2 capsid proteins. Polymerase chain reaction, Western Blot and indirect immu

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26

Shih-jing and 施靖瑜. "The Effects Of Human Parvovirus B19 VP1Unique Region On Macrophage." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/67061420760538064278.

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碩士<br>中山醫學大學<br>免疫學研究所<br>96<br>Human Parvovirus B19 (B19) have two structural protein ,VP1 (83KDa) and VP2 (58KDa), which are identical except for 227 amino acids at the amino-terminal end of the VP1-protein, the so-called VP1-unique region (VP1u). Recently, a phospholipase A2 (PLA2) motif was identified in the VP1u and has been classified as group XIII sPLA2, which the mechanism remains unclear. Previous studies have shown that B19-VP1u PLA2 motif can stimulate activation of synoviocytes. However, the effects of B19-VP1u PLA2 motif on initiating innate immunity by macrophages are still unkno

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27

Hsu, Tsai-Ching, and 徐再靜. "The Study of Human Parvovirus B19 Infection And Autoimmune Diseases." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/96565108112425923911.

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博士<br>中山醫學大學<br>醫學研究所<br>92<br>Previously, we described four patients who had clinical diagnosis of erythema infectiosum and presented with skin rash, polyarthralgia, and polyarthritis. Anticardiolipin antibody (aCL) and anti-neutrophil cytoplasmic antibody (ANCA) were also positive in these patients. These data indicate parvovirus B19 may be linked to the induction of an autoimmune response. In order to understand the relationship between B19 infection and autoimmune diseases, we then launch a series of research on them. Parvovirus B19 DNA was detected in 17 of 72 patients with SLE, but not i

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28

Ju, Cheng, and 鄭儒. "The study of human parvovirus B19 infection and anti-phospholipid antibodies." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/51656287136227222383.

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碩士<br>中山醫學大學<br>生化微生物免疫研究所<br>104<br>Human parvovirus B19 (B19) is classified as Parvoviridae family and known causing disease in humans. The virus capsid is composed of two structural proteins, VP1 and VP2, which are identical except for 227 amino acids at the amino-terminal end of the VP1-protein, the so-called VP1-unique region (VP1u). B19-VP1u proteins have secretary phospholipase A2 (sPLA2) activity, which is essential for viral infectivity and as the region to neutralize the immune response (VP1u-IgG). Previous studies show B19-VP1u induces the production of anti-phospholipid antibody. T

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29

Van, Niekerk Albertus Bernhardus Willer. "Investigation of the role of human parvovirus B19 in chronic anaemia of HIV infected TB patients." Thesis, 1994. https://hdl.handle.net/10539/26637.

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A dissertation submitted to the Faculty of Medicine, University of the Witwatersrand, in partial fulfilment of the requirements for the degree Master of Medicine (Virology)<br>This study was undertaken to determine the role of human parvovlrus B19 (B19) in chronic anaemia of HIV infected TB patients. Patlents were selected from an existing databank of 307 patients included in a MRC HIV/TB study. Twenty-nine patients, 15 colnfected with HIV /TB and 14 Infected with TB only, were identified for further evaluation. These patient's era were subjected to serological and DNA detection studies

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30

Chun-Chou and 蔡鈞州. "The Study of Antibody Response to Human Parvovirus B19 Non-Structural Protein." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/5dyba5.

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碩士<br>中山醫學大學<br>免疫學研究所<br>96<br>Human parvovirus B19 (B19) was classified as the Erythrovirus genus of the Parvoviridae family and the member known to be pathologic in hu-man. B19 is a single-stranded DNA virus with 5596 nucleotides, composed of capsid protein (VP) and non-structural (NS1) proteins. Previous studies have shown that the NS1-specific antibodies could be de-tected in B19 patients with chronic or persistent infection and associated with B19-related arthralgia. However, the role of anti-B19-NS1 antibody in patients with autoimmune diseases is still unknown. In this study nested PCR

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31

Chen, Li-Jeng, and 陳俐礽. "Protective effects of Cystamine against human parvovirus B19-NS1 induced hepatic injury." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/62124371999683124828.

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碩士<br>中山醫學大學<br>生化暨生物科技研究所<br>102<br>Human Parvovirus B19 (B19) infection is known to induce apoptosis and liver dysfunction. Cystamine is indicated in preventing apoptosis and it has been demonstrated to be beneficial on attenuating the hepatic injury in mice. Since our previous study demonstrated that B19-NS1 in development of autoimmunity by inducing apoptosis and aggravates liver injury, we herein intend to investigate the effect of cystamine on B19-NS1 induced hepatic iniury in BALB/c mice. For cystamine treatment, B19-NS1 BALB/c mice were injected intraperitoneally (i.p.) with cystamine

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32

Tsai, Chun-Chou, and 蔡鈞州. "Study of Human Parvovirus B19 Proteins on Liver of NZB/W F1 mice." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/bkp37h.

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博士<br>中山醫學大學<br>微生物免疫研究所<br>101<br>Human Parvovirus B19 (B19) infection has been associated with the production of various autoantibodies and recognized as a cause or trigger of autoimmune diseases. However, the precise mechanism is still unclear. Previous studies have reported that B19 may exacerbate or induce systemic lupus erythematous (SLE). Herein, we aimed to inves-tigate the effects of B19 on liver in NZB/W F1 mice by injecting B19 viral proteins. In Part I, we passive transfer of rabbit anti-B19-VP1u IgG was injected intravenously into NZB/W F1 mice. Significant increases of APhL, and

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33

Chang, Shun-Chih, and 張舜智. "Study of Human Parvovirus B19-VP1u Proteins on Liver of Balb/c Mice." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/88115625755768995675.

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碩士<br>中山醫學大學<br>微生物免疫研究所<br>101<br>Human Parvovirus B19 is a significant human pathogen in Parvoviridae. It has been re-ported that B19 can be detected in blood or liver specimens in patient with liver diseases. Indeed, various studies have postulated a connection between B19 infection and liver injury. Recently, studies suggested that the PLA2 motif of B19-VP1u play an important role in closely associated with B19-infected and inflammatory. However, the precise mechanism is still obscure. In the present study, we aimed to investigate the influence of B19-VP1u in Balb/c mice by injected subcut

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34

St, Amand Janet Lynn. "Identification and characterization of small rnas and proteins expressed by the human parvovirus B19." Thesis, 1992. http://hdl.handle.net/2429/3329.

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The human pathogenic parvovirus B19 has a strict tissue tropism and will only replicate in a subset of erythroid progenitor cells. However, it is shown that COS-7 cells transfected with SV4O-B19 hybrid vectors express the major B19 RNAs and proteins. In addition, capsid proteins synthesized in these cells self-assemble into virus particles that by EM are morphologically very similar to native B19 virions. Cytoplasmic RNA from transfected COS-7 cells was used to prepare a cDNA library using a method which enriched the library for B19 cDNAs. A second cDNA library was prepared from B19 inf

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35

Chun-Ching and 邱駿清. "The Effects of Antibody Against Human Parvovirus B19 VP1 unique region On Vascular Endothelial Cells." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/57807008492890659014.

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碩士<br>中山醫學大學<br>免疫學研究所<br>98<br>Human parvovirus B19 infection has been frequently described as a cause or trigger of various autoimmune diseases. In previous studies, we have postulated the association among human parvovirus B19 (B19)-VP1unique region (VP1u), production of anti-beta2-glycoprotein I (anti-β2GPI) antibody and anti-phospholipid syndrome (APS)-like autoimmunity. However, the precise role of B19-VP1u in induction of APS is still obscure. To further elucidate the pathogenic roles of VP1u in B19 infection and autoimmunity, we examined the effect of anti-B19-VP1u IgG antibodies on en

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36

Huang, Zi-Yun, and 黃子芸. "The Effects of Human parvovirus B19 VP1 unique region on heart of Balb/c mice." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/cfd78t.

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37

van, Niekerk Albetus Bernhardus Willer. "Investigation of the role of human parvovirus B19 in chronic anaemia of hiv infected TB patients." Thesis, 1994. https://hdl.handle.net/10539/26457.

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A dissertation submitted to the Faculty of Medicine, University of the Witwatersrand, in partial fulfilment of the requirements for the degree Master of Medicine (Virology)<br>This study was undertaken to determine the role of human parvovirus B19 (B19) in chronic anaemia of HIV infected TB patients. Patients were selected from an existing databank of 307 patients included in a MRC HIV/TB study. Twenty-nine patients, 15 coinfected with HIV/TB and 14 infected with TB only, were identified for further evaluation. These patients’ sera were subjected to serological and DNA detection studies using

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38

Tsung-Min and 林宗旻. "The Effects of Human parvovirus B19 VP1 unique region on heart of NZB/W F1 mice." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/58300165477411200242.

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碩士<br>中山醫學大學<br>免疫學研究所<br>98<br>Human parvovirus B19 is one of the Parvoviridae family and known to be pathologic in humans. The capsid of parvovirus B19 consists of two structural proteins, VP1 and VP2, which are identical except for 227 amino acids at the amino-terminal end of the VP1 protein. So the additional 227 amino acids at VP1 amino-terminus were called VP1-unique region (VP1u). Recently, more and more literatures assumed that there is a link between B19 infection and myocarditis, but the detailed mechanisms are still unknown. In addition, parvovirus B19 infection has been associated

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39

Lee, Wen Chi, and 李汶錡. "The Effects of Human parvovirus B19 VP1 unique region antibody on heart of Balb/c mice." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/geq8dh.

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40

Chen, Ren-Mo, and 陳壬模. "The study of human parvovirus B19 non-structure protein (NS-1) and 24-peptide antibodies in autoimmune diseases." Thesis, 2000. http://ndltd.ncl.edu.tw/handle/38042705581468569389.

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碩士<br>中山醫學院<br>生物化學研究所<br>88<br>Objective: To analyze the reactivity of the autoimmune diseases patients sera with the parvovirus B19 proteins, 24- peptide and NS-1 was used as solid-phase antigen in an enzyme linked immunosorbent assay (ELISA) to screen human sera. Method : Sera from 80 patients with systemic lupus erythematous (SLE), 79 patientswith rheumatoid arthritis (RA), 4 patients with Sjogren''s syndrome (SS), 3 patients with sy

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41

Lee, Yuan-Ming, and 李元明. "The Study of Serological and Molecular Epidemiology of Human Herpes Virus Type 8, Human Parvovirus Type B19 and Human Influenza Virus Type B Infection in Different Populations in Taiwan." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/68196045473080802153.

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博士<br>國立陽明大學<br>公共衛生研究所<br>101<br>The aim of this study was to conduct serological and molecular epidemiology of Human herpes virus type 8( HHV-8), human parvovirus type B19( B19) and human influenza virus type B( Flu B) infections in different populations in Taiwan. HHV-8, the causal agent of Kaposi’s sarcoma, is transmitted sexually among homosexual men, but little is known of its transmission among injection drug users (IDUs). In contrast, B19, a causative agent for anemia, is most frequently detected in IDUs. A total of 744 serum samples among them 515 from IDUs and homosexual men attendi

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Chiu, Chun-Ching, and 邱駿清. "I. Mechanisms of the Beneficial Effects of Ocimum gratissimum aqueous extract on rats with CCl4-induced acute liver injuryII. Effects of Human Parvovirus B19 And Bocavirus VP1 Unique Region On Tight Junction Of Human Airway Epithelial A549 Cells." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/04185308548567307464.

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博士<br>中山醫學大學<br>微生物免疫研究所<br>103<br>Ocimum gratissimum (OG) is known as a food spice and traditional herb, which has been recommended for the treatment of various diseases. To investigate the hepatoprotective effect of OG aqueous extract (OGAE), male Wistar rats challenged by carbon tetrachloride (CCl4) were used as the animal model of hepatic injury. Our data imply that OGAE can effi-ciently inhibit CCl4-induced liver injuries in rats and may therefore be a potential food or herb for preventing liver injuries. As is widely recognized, human parvovirus B19 (B19) and human bocavirus (HBoV) are

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